DE69701319T2 - Bioverträgliche zusammensetzungen - Google Patents
Bioverträgliche zusammensetzungenInfo
- Publication number
- DE69701319T2 DE69701319T2 DE69701319T DE69701319T DE69701319T2 DE 69701319 T2 DE69701319 T2 DE 69701319T2 DE 69701319 T DE69701319 T DE 69701319T DE 69701319 T DE69701319 T DE 69701319T DE 69701319 T2 DE69701319 T2 DE 69701319T2
- Authority
- DE
- Germany
- Prior art keywords
- heparin
- polymer
- coated
- methacrylate
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 229920000669 heparin Polymers 0.000 abstract 3
- 229960002897 heparin Drugs 0.000 abstract 3
- 239000000178 monomer Substances 0.000 abstract 3
- GYXOHPLRXDQGBP-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;2-methylprop-2-enoate Chemical compound CC(=C)C([O-])=O.C[N+](C)(C)CCO GYXOHPLRXDQGBP-UHFFFAOYSA-M 0.000 abstract 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000008199 coating composition Substances 0.000 abstract 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002607 heparin antagonist Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229920001897 terpolymer Polymers 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9624130.2A GB9624130D0 (en) | 1996-11-20 | 1996-11-20 | Biocompatible compositions |
PCT/GB1997/003189 WO1998022516A1 (en) | 1996-11-20 | 1997-11-20 | Biocompatible compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69701319D1 DE69701319D1 (de) | 2000-03-30 |
DE69701319T2 true DE69701319T2 (de) | 2000-07-13 |
Family
ID=10803229
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69711913T Expired - Lifetime DE69711913T2 (de) | 1996-11-20 | 1997-11-20 | Anionenaustauschmaterialien und verfahren |
DE69701319T Expired - Lifetime DE69701319T2 (de) | 1996-11-20 | 1997-11-20 | Bioverträgliche zusammensetzungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69711913T Expired - Lifetime DE69711913T2 (de) | 1996-11-20 | 1997-11-20 | Anionenaustauschmaterialien und verfahren |
Country Status (11)
Country | Link |
---|---|
US (2) | US6251964B1 (de) |
EP (2) | EP0939779B1 (de) |
JP (2) | JP4295359B2 (de) |
AT (2) | ATE215971T1 (de) |
AU (3) | AU728887B2 (de) |
CA (1) | CA2271132C (de) |
DE (2) | DE69711913T2 (de) |
ES (1) | ES2143301T3 (de) |
GB (1) | GB9624130D0 (de) |
WO (3) | WO1998022516A1 (de) |
ZA (3) | ZA9710468B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743878B2 (en) | 1991-07-05 | 2004-06-01 | Biocompatibles Uk Limited | Polymeric surface coatings |
GB9522332D0 (en) | 1995-11-01 | 1996-01-03 | Biocompatibles Ltd | Braided stent |
US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
EP1095665B1 (de) * | 1998-07-07 | 2008-09-03 | Nof Corporation | Zusammensetzung zur wundheilung, wundverband und verfahren zur behandlung vonwunden |
WO2000035980A1 (en) * | 1998-12-11 | 2000-06-22 | Biocompatibles Limited | Crosslinked polymers and refractive devices formed therefrom |
WO2001009208A1 (en) | 1999-05-27 | 2001-02-08 | Biocompatibles Limited | Polymer solutions |
ATE319421T1 (de) | 1999-05-27 | 2006-03-15 | Biocompatibles Uk Ltd | Lokale arzneistoffabgabe |
AU2001228653A1 (en) * | 2000-01-24 | 2001-07-31 | Biocompatibles Limited | Coated implants |
EP1325046B1 (de) | 2000-10-06 | 2007-06-27 | Biocompatibles UK Limited | Zwitterionische polymere |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
US8252531B2 (en) | 2001-04-26 | 2012-08-28 | Nof Corporation | Nonspecific hybridization inhibitors, clinical examination reagents and clinical examination method |
US6844028B2 (en) * | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
EP1480680B1 (de) | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Mit nucleinsäure complexierte block-copolymere |
WO2005027991A1 (en) * | 2003-09-19 | 2005-03-31 | Cambridge University Technical Services Ltd | Orthopaedic devices |
US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US7892284B2 (en) * | 2005-02-28 | 2011-02-22 | Hoya Corporation | Intraocular lens and process for producing the same |
WO2008006912A2 (en) * | 2006-07-14 | 2008-01-17 | Biocompatibles Uk Limited | Polymer |
WO2008064058A2 (en) | 2006-11-21 | 2008-05-29 | Abbott Laboratories | Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings |
US20080286332A1 (en) | 2007-05-14 | 2008-11-20 | Pacetti Stephen D | Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties |
JP5019524B2 (ja) * | 2007-06-01 | 2012-09-05 | 国立大学法人 東京大学 | 新規ポリ(メタ)アクリレート共重合体ならびに小胞体及びゴルジ体への送達方法 |
WO2010065958A1 (en) | 2008-12-05 | 2010-06-10 | Semprus Biosciences Corp. | Layered non-fouling, antimicrobial, antithrombogenic coatings |
SG186180A1 (en) | 2010-06-09 | 2013-01-30 | Semprus Biosciences Corp | Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions |
CA2799786A1 (en) | 2010-06-09 | 2011-12-15 | Semprus Biosciences Corp. | Non-fouling, anti-microbial, anti-thrombogenic graft compositions |
WO2012162789A1 (en) | 2011-06-01 | 2012-12-06 | University Of British Columbia | Polymers for reversing heparin-based anticoagulation |
EP2791213A4 (de) | 2011-12-14 | 2015-10-28 | Semprus Biosciences Corp | Mit lanthanid- oder übergangsmetalloxidantien modifizierte silikonhydrogekontaktlinse |
EP2791223A4 (de) | 2011-12-14 | 2015-11-18 | Semprus Biosciences Corp | Oberflächenmodifizierte kontaktlinsen |
AU2012351991B2 (en) | 2011-12-14 | 2015-09-24 | Semprus Biosciences Corp. | Multistep UV process to create surface modified contact lenses |
AU2012368232B2 (en) | 2011-12-14 | 2016-01-07 | Arrow International, Inc. | Imbibing process for contact lens surface modification |
CA2859047C (en) | 2011-12-14 | 2017-03-21 | Semprus Biosciences Corp. | Redox processes for contact lens modification |
CN103193927B (zh) * | 2013-04-27 | 2016-01-20 | 南京构友生物材料有限公司 | 可键合的血液友好聚合物及其制法与用途 |
CN105283521B (zh) * | 2013-05-27 | 2018-05-11 | Jsr株式会社 | 由无机材料构成的表面用的表面处理剂、表面被改性的器具和装置、该器具和装置的制造方法 |
US10384167B2 (en) | 2013-11-21 | 2019-08-20 | Oasys Water LLC | Systems and methods for improving performance of osmotically driven membrane systems |
WO2016052618A1 (ja) | 2014-10-02 | 2016-04-07 | 旭化成メディカル株式会社 | 生体由来液処理フィルター及びフィルターデバイス |
KR20180076552A (ko) * | 2016-12-28 | 2018-07-06 | 주식회사 엘지화학 | 친수성 코팅 조성물 |
CN113939358A (zh) * | 2019-05-10 | 2022-01-14 | 塔夫茨大学信托人 | 两性离子带电共聚物膜 |
CN117545488A (zh) | 2021-05-27 | 2024-02-09 | 麦德龙国际生物科技有限责任公司 | 烟酸单核苷酸及其酯的结晶固体以及其制作和使用方法 |
CN113476661B (zh) * | 2021-07-05 | 2022-08-05 | 中国医学科学院生物医学工程研究所 | 一种三层结构复合型自愈合人造血管及其制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE306597B (de) | 1964-12-17 | 1968-12-02 | Incentive Ab | |
US3861948A (en) * | 1972-05-22 | 1975-01-21 | Kendall & Co | Pressure sensitive adhesive tape |
US3839237A (en) * | 1972-05-31 | 1974-10-01 | Ici Australia Ltd | Ion exchange resins having both acidic and basic ion-exchange sites |
SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
US4517241A (en) * | 1982-12-02 | 1985-05-14 | Alpert Andrew J | Chromatographic support material |
US4704324A (en) * | 1985-04-03 | 1987-11-03 | The Dow Chemical Company | Semi-permeable membranes prepared via reaction of cationic groups with nucleophilic groups |
US4865870A (en) | 1988-07-07 | 1989-09-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic |
JP2890316B2 (ja) * | 1989-07-07 | 1999-05-10 | 科学技術振興事業団 | 生体適合性医療デバイス用材料 |
GB9023498D0 (en) | 1990-10-29 | 1990-12-12 | Biocompatibles Ltd | Soft contact lens material |
US5075399A (en) * | 1990-11-15 | 1991-12-24 | Phillips Petroleum Company | Superabsorbent crosslinked ampholytic ion pair copolymers |
EP0593561B1 (de) * | 1991-07-05 | 2000-03-22 | Biocompatibles Limited | Polymere oberflächenbeschichtungszusammensetzungen |
WO1993014127A1 (en) * | 1992-01-21 | 1993-07-22 | University Of Utah | Method and composition for heparin binding using polyaminocations covalently immobilised on polymeric surfaces with polyethylene oxide spacers |
US5556710A (en) | 1992-04-24 | 1996-09-17 | Biocompatibles Limited | Metal coating useful for rendering the surface of the metal biocompatible |
US5342621A (en) * | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
GB9226791D0 (en) * | 1992-12-23 | 1993-02-17 | Biocompatibles Ltd | New materials |
JPH07184989A (ja) | 1993-12-28 | 1995-07-25 | Kuraray Co Ltd | 血液適合性医療用高分子材料および医療材料 |
JPH07285831A (ja) * | 1994-04-18 | 1995-10-31 | Mitsubishi Chem Corp | 毛髪化粧料組成物 |
-
1996
- 1996-11-20 GB GBGB9624130.2A patent/GB9624130D0/en active Pending
-
1997
- 1997-11-20 EP EP97913311A patent/EP0939779B1/de not_active Expired - Lifetime
- 1997-11-20 US US09/117,729 patent/US6251964B1/en not_active Expired - Lifetime
- 1997-11-20 ZA ZA9710468A patent/ZA9710468B/xx unknown
- 1997-11-20 JP JP52336298A patent/JP4295359B2/ja not_active Expired - Lifetime
- 1997-11-20 JP JP52336498A patent/JP4051414B2/ja not_active Expired - Fee Related
- 1997-11-20 DE DE69711913T patent/DE69711913T2/de not_active Expired - Lifetime
- 1997-11-20 ZA ZA9710467A patent/ZA9710467B/xx unknown
- 1997-11-20 ZA ZA9710466A patent/ZA9710466B/xx unknown
- 1997-11-20 AU AU50608/98A patent/AU728887B2/en not_active Ceased
- 1997-11-20 AU AU50611/98A patent/AU5061198A/en not_active Abandoned
- 1997-11-20 WO PCT/GB1997/003189 patent/WO1998022516A1/en active IP Right Grant
- 1997-11-20 AU AU50610/98A patent/AU5061098A/en not_active Abandoned
- 1997-11-20 DE DE69701319T patent/DE69701319T2/de not_active Expired - Lifetime
- 1997-11-20 ES ES97913308T patent/ES2143301T3/es not_active Expired - Lifetime
- 1997-11-20 AT AT97913311T patent/ATE215971T1/de not_active IP Right Cessation
- 1997-11-20 EP EP97913308A patent/EP0866815B1/de not_active Expired - Lifetime
- 1997-11-20 CA CA002271132A patent/CA2271132C/en not_active Expired - Fee Related
- 1997-11-20 US US09/308,496 patent/US6432314B1/en not_active Expired - Lifetime
- 1997-11-20 WO PCT/GB1997/003192 patent/WO1998022517A1/en active IP Right Grant
- 1997-11-20 AT AT97913308T patent/ATE189899T1/de not_active IP Right Cessation
- 1997-11-20 WO PCT/GB1997/003191 patent/WO1998022162A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2271132A1 (en) | 1998-05-28 |
DE69701319D1 (de) | 2000-03-30 |
GB9624130D0 (en) | 1997-01-08 |
JP2001506915A (ja) | 2001-05-29 |
EP0866815A2 (de) | 1998-09-30 |
AU5061198A (en) | 1998-06-10 |
JP4295359B2 (ja) | 2009-07-15 |
ZA9710466B (en) | 1998-11-20 |
WO1998022162A1 (en) | 1998-05-28 |
AU5060898A (en) | 1998-06-10 |
AU5061098A (en) | 1998-06-10 |
ES2143301T3 (es) | 2000-05-01 |
WO1998022517A1 (en) | 1998-05-28 |
DE69711913T2 (de) | 2002-10-10 |
ZA9710467B (en) | 1998-11-20 |
EP0866815A3 (de) | 1998-10-21 |
JP2001504877A (ja) | 2001-04-10 |
US6432314B1 (en) | 2002-08-13 |
JP4051414B2 (ja) | 2008-02-27 |
ATE215971T1 (de) | 2002-04-15 |
EP0866815B1 (de) | 2000-02-23 |
WO1998022516A1 (en) | 1998-05-28 |
CA2271132C (en) | 2007-04-17 |
ZA9710468B (en) | 1998-11-20 |
EP0939779B1 (de) | 2002-04-10 |
EP0939779A1 (de) | 1999-09-08 |
AU728887B2 (en) | 2001-01-18 |
DE69711913D1 (de) | 2002-05-16 |
US6251964B1 (en) | 2001-06-26 |
ATE189899T1 (de) | 2000-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BIOCOMPATIBLES UK LTD., FARNHAM, SURREY, GB |