DE69707870D1 - Quartäre cytofectine - Google Patents
Quartäre cytofectineInfo
- Publication number
- DE69707870D1 DE69707870D1 DE69707870T DE69707870T DE69707870D1 DE 69707870 D1 DE69707870 D1 DE 69707870D1 DE 69707870 T DE69707870 T DE 69707870T DE 69707870 T DE69707870 T DE 69707870T DE 69707870 D1 DE69707870 D1 DE 69707870D1
- Authority
- DE
- Germany
- Prior art keywords
- cytofectine
- quarterly
- lipids
- transfective
- derivatized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/629,965 US5994317A (en) | 1996-04-09 | 1996-04-09 | Quaternary cytofectins |
PCT/US1997/005757 WO1997037966A1 (en) | 1996-04-09 | 1997-04-08 | Quaternary cytofectins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69707870D1 true DE69707870D1 (de) | 2001-12-06 |
DE69707870T2 DE69707870T2 (de) | 2002-07-11 |
Family
ID=24525211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69707870T Expired - Lifetime DE69707870T2 (de) | 1996-04-09 | 1997-04-08 | Quartäre cytofectine |
Country Status (9)
Country | Link |
---|---|
US (1) | US5994317A (de) |
EP (1) | EP0902780B1 (de) |
JP (1) | JP4031045B2 (de) |
AT (1) | ATE207874T1 (de) |
CA (1) | CA2251169C (de) |
DE (1) | DE69707870T2 (de) |
DK (1) | DK0902780T3 (de) |
ES (1) | ES2166540T3 (de) |
WO (1) | WO1997037966A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
DE69031951T2 (de) | 1989-11-16 | 1998-08-13 | Du Pont | Transformation von tierischen Hautzellen mit hilfe von Partikeln |
US6706694B1 (en) | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
US6228844B1 (en) | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
US7105574B1 (en) | 1999-03-26 | 2006-09-12 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
JP2001523480A (ja) * | 1997-11-20 | 2001-11-27 | バイカル インコーポレイテッド | サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置 |
US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
EP1165140B1 (de) * | 1999-03-26 | 2004-08-04 | Vical Incorporated | Adjuvanszusammensetzungen zur erhöhung der immunantwort auf polynukleotid-basierende impfstoffe |
WO2001017945A1 (en) * | 1999-09-03 | 2001-03-15 | The Procter & Gamble Company | Cationic alkyl alkoxylate derivatives |
EP1278551A2 (de) * | 2000-04-21 | 2003-01-29 | Vical Incorporated | Zusammensetzungen und verfahren zur (in vivo) verabreichung der auf polynukleotiden-basierenden therapeutika |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
KR100381512B1 (ko) | 2000-09-21 | 2003-04-26 | 굿젠 주식회사 | 유전자 및 생물학적 활성 약물 전달용 양이온성 지질과이의 용도 |
CA2436830A1 (en) * | 2000-11-06 | 2002-06-20 | Asilomar Pharmaceuticals, Inc. | Intracellular delivery of charged therapeutic moieties to nerve cells by means of targeting proteins |
WO2002098465A2 (en) * | 2001-06-07 | 2002-12-12 | Celator Technologies, Inc. | Cell penetrating therapeutic agents |
EP3100719A3 (de) | 2002-05-15 | 2017-02-22 | California Pacific Medical Center | Zuführung von nukleinsäureähnlichen verbindungen |
AU2003278776A1 (en) * | 2002-09-10 | 2004-04-30 | Vical Incorporated | Codon-optimized polynucleotide-based vaccines against bacillus anthracis infection |
US7381422B2 (en) | 2002-12-23 | 2008-06-03 | Vical Incorporated | Method for producing sterile polynucleotide based medicaments |
CA2508279A1 (en) * | 2002-12-23 | 2004-07-22 | Vical Incorporated | Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes |
US8080642B2 (en) * | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
EP1804835B9 (de) | 2004-09-13 | 2012-05-02 | Genzyme Corporation | Multimere konstrukte |
US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
WO2008106646A2 (en) * | 2007-03-01 | 2008-09-04 | Introgen Therapeutics, Inc | Methods and formulations for topical gene therapy |
US20130129811A1 (en) * | 2010-04-28 | 2013-05-23 | Takeshi Kuboyama | Cationic lipid |
AU2011245987B2 (en) * | 2010-04-28 | 2016-12-15 | Kyowa Hakko Kirin Co., Ltd | Cationic lipid |
JP2013095755A (ja) * | 2011-11-02 | 2013-05-20 | Kyowa Hakko Kirin Co Ltd | カチオン性脂質 |
AU2013270685B2 (en) * | 2012-06-08 | 2017-11-30 | Nitto Denko Corporation | Lipids for therapeutic agent delivery formulations |
CN107427531A (zh) | 2015-03-24 | 2017-12-01 | 协和发酵麒麟株式会社 | 含有核酸的脂质纳米粒子 |
EP3823674A4 (de) | 2018-07-18 | 2022-12-28 | Manzanita Pharmaceuticals, Inc. | Konjugate zur abgabe eines krebsmittels an nervenzellen, verwendungsverfahren und verfahren zu deren herstellung |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2368208A (en) * | 1940-12-16 | 1945-01-30 | Emulsol Corp | Chemical compounds and method of preparing same |
US3265719A (en) * | 1959-12-28 | 1966-08-09 | American Cyanamid Co | Betaines |
DE2651898A1 (de) * | 1976-11-13 | 1978-05-18 | Hoechst Ag | Waescheweichspuelmittel |
US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
DE3618517A1 (de) * | 1985-06-04 | 1986-12-04 | Lion Corp., Tokio/Tokyo | Emulgiermittel zur emulsionspolymerisation |
US4864060A (en) * | 1987-08-31 | 1989-09-05 | Witco Corporation | Surface active compounds, methods for making same and uses thereof |
US5068431A (en) * | 1987-08-31 | 1991-11-26 | Witco Corporation | Methods of making new surface active compounds |
CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
JPH03181597A (ja) * | 1989-12-12 | 1991-08-07 | Bridgestone Corp | 電気粘性流体 |
US5279833A (en) * | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5334761A (en) * | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
DE4241983C1 (de) * | 1992-12-12 | 1994-03-24 | Messer Griesheim Gmbh | Schutzgas für das Lichtbogenschweißen von Aluminium |
US5364324A (en) * | 1992-12-14 | 1994-11-15 | Boettiger Jr Walter W | Exercise device |
US5753613A (en) * | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
-
1996
- 1996-04-09 US US08/629,965 patent/US5994317A/en not_active Expired - Lifetime
-
1997
- 1997-04-08 CA CA002251169A patent/CA2251169C/en not_active Expired - Fee Related
- 1997-04-08 DK DK97920200T patent/DK0902780T3/da active
- 1997-04-08 EP EP97920200A patent/EP0902780B1/de not_active Expired - Lifetime
- 1997-04-08 ES ES97920200T patent/ES2166540T3/es not_active Expired - Lifetime
- 1997-04-08 JP JP53642397A patent/JP4031045B2/ja not_active Expired - Fee Related
- 1997-04-08 DE DE69707870T patent/DE69707870T2/de not_active Expired - Lifetime
- 1997-04-08 AT AT97920200T patent/ATE207874T1/de not_active IP Right Cessation
- 1997-04-08 WO PCT/US1997/005757 patent/WO1997037966A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE207874T1 (de) | 2001-11-15 |
JP2000508642A (ja) | 2000-07-11 |
CA2251169A1 (en) | 1997-10-16 |
EP0902780B1 (de) | 2001-10-31 |
EP0902780A1 (de) | 1999-03-24 |
ES2166540T3 (es) | 2002-04-16 |
JP4031045B2 (ja) | 2008-01-09 |
DK0902780T3 (da) | 2002-02-11 |
US5994317A (en) | 1999-11-30 |
CA2251169C (en) | 2006-12-19 |
DE69707870T2 (de) | 2002-07-11 |
WO1997037966A1 (en) | 1997-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |