DE69720811D1 - L-Ribavirin und dessen Verwendung - Google Patents

L-Ribavirin und dessen Verwendung

Info

Publication number
DE69720811D1
DE69720811D1 DE69720811T DE69720811T DE69720811D1 DE 69720811 D1 DE69720811 D1 DE 69720811D1 DE 69720811 T DE69720811 T DE 69720811T DE 69720811 T DE69720811 T DE 69720811T DE 69720811 D1 DE69720811 D1 DE 69720811D1
Authority
DE
Germany
Prior art keywords
compounds
useful
novel
diseases
infestations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69720811T
Other languages
English (en)
Other versions
DE69720811T2 (de
Inventor
Kandasamy Ramasamy
Robert Tam
Devron Averett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Research and Development
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of DE69720811D1 publication Critical patent/DE69720811D1/de
Application granted granted Critical
Publication of DE69720811T2 publication Critical patent/DE69720811T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
DE69720811T 1996-10-16 1997-10-15 L-Ribavirin und dessen Verwendung Expired - Fee Related DE69720811T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2858596P 1996-10-16 1996-10-16
US28585P 1996-10-16

Publications (2)

Publication Number Publication Date
DE69720811D1 true DE69720811D1 (de) 2003-05-15
DE69720811T2 DE69720811T2 (de) 2004-03-11

Family

ID=21844262

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69720811T Expired - Fee Related DE69720811T2 (de) 1996-10-16 1997-10-15 L-Ribavirin und dessen Verwendung
DE69721339T Expired - Fee Related DE69721339T2 (de) 1996-10-16 1997-10-15 Monozyklische l-nukleoside, analoga und ihre anwendungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69721339T Expired - Fee Related DE69721339T2 (de) 1996-10-16 1997-10-15 Monozyklische l-nukleoside, analoga und ihre anwendungen

Country Status (26)

Country Link
US (4) US6130326A (de)
EP (1) EP1027359B9 (de)
JP (2) JP2002503212A (de)
KR (1) KR100398923B1 (de)
CN (1) CN1268140A (de)
AT (2) ATE236921T1 (de)
AU (1) AU738170B2 (de)
BR (1) BR9712527A (de)
CA (1) CA2267279A1 (de)
CZ (1) CZ120699A3 (de)
DE (2) DE69720811T2 (de)
DK (2) DK1027359T3 (de)
ES (2) ES2195125T3 (de)
HK (2) HK1038365A1 (de)
HU (1) HUP0001107A3 (de)
IL (1) IL129126A0 (de)
NO (1) NO313417B1 (de)
NZ (1) NZ334915A (de)
PL (1) PL187107B1 (de)
PT (2) PT1132393E (de)
RU (2) RU2188828C2 (de)
SI (1) SI20076A (de)
SK (1) SK284054B6 (de)
UA (1) UA63915C2 (de)
WO (1) WO1998016186A2 (de)
YU (1) YU18799A (de)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1132393E (pt) * 1996-10-16 2003-08-29 Ribapharm Inc L-ribavirina e usos da mesma
YU67099A (sh) * 1997-06-30 2002-06-19 Icn Pharmaceuticals Inc. Postupak za dobijanje tiazofurina i drugih c-nukleozida
JP4596495B2 (ja) * 1997-07-18 2010-12-08 ソニー株式会社 制御装置、制御方法、電気機器システム、電気機器システムの制御方法、および、記録媒体
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
MXPA01004504A (es) 1998-11-05 2005-04-19 Centre Nat Rech Scient Nucleosidos con actividad contra virus de la hepatitis b.
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
JP2002528510A (ja) * 1998-11-05 2002-09-03 サントル・ナシオナル・ドウ・ラ・ルシエルシユ・シアンテイフイク ＨＩＶ感染の治療のためのβ−Ｌ−２’−デオキシ−ヌクレオシド
BR9917090A (pt) * 1999-01-29 2001-10-16 Icn Pharmaceuticals Modulação de resposta imune por ribavirina
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
KR100782896B1 (ko) 1999-05-04 2007-12-06 엑시콘 에이/에스 Ｌ-리보-ｌｎａ 유사체
US6525191B1 (en) * 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
CA2382324A1 (en) * 1999-08-31 2001-03-08 Amersham Plc Nucleoside analogues
US6664399B1 (en) * 1999-09-02 2003-12-16 E. I. Du Pont De Nemours & Company Triazole linked carbohydrates
US6518253B1 (en) * 1999-11-19 2003-02-11 Robert Tam Treatment of viral infections using the L-isomer of ribavirin
YU47802A (sh) * 1999-12-23 2006-03-03 Ribapharm Postupci i kompozicije za levovirin
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US6455508B1 (en) * 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
BR0110023A (pt) * 2000-04-13 2003-12-30 Pharmasset Ltd Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1294735A2 (de) * 2000-05-26 2003-03-26 Novirio Pharmaceuticals Limited Verfahren und zusammensetzungen zur behandlung von flaviviren und pestiviren
US6815542B2 (en) * 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
RU2286172C2 (ru) 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
EP2332574A1 (de) 2000-08-17 2011-06-15 Tripep Ab HCV NS3/4A Sequenzen
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
ES2208540T3 (es) * 2001-07-30 2004-06-16 Clariant Life Science Molecules (Italia) Spa Procedimiento para la preparacion de ribavirina.
EP1435974A4 (de) * 2001-09-28 2006-09-06 Idenix Cayman Ltd Verfahren und zusamemnsetzungen zur behandlung des hepatitis-c-virus mit 4'-modifizierten nucleosiden
WO2003039517A1 (en) * 2001-11-02 2003-05-15 Sandoz Inc. Process for preparing quick dissolving, high loading ribavirin compositions
KR100411398B1 (ko) * 2001-12-06 2003-12-18 주식회사유한양행 베타-디-리보푸라노즈 유도체의 제조방법
AU2003213628A1 (en) * 2002-02-28 2003-09-16 Biota, Inc. Nucleoside 5'-monophosphate mimics and their prodrugs
EP1501435B1 (de) 2002-05-06 2007-08-29 Covidien AG Blutdetektor zur kontrolle einer elektrochirurgischen einheit
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
KR20050035194A (ko) * 2002-06-28 2005-04-15 이데닉스 (케이만) 리미티드 플라비비리다에 감염 치료용 2'-ｃ-메틸-3'-ｏ-ｌ-발린에스테르 리보푸라노실 사이티딘
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
JP2006507235A (ja) * 2002-08-01 2006-03-02 フアーマセツト・インコーポレイテツド フラビウイルス科ウイルス感染治療のためのビシクロ［４．２．１］ノナン系を有する化合物
EP1537134B1 (de) * 2002-08-12 2006-04-05 F.Hoffmann-La Roche Ag Verfahren zur herstellung von einem ribofuranose
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
ZA200503511B (en) 2002-10-29 2006-10-25 Coley Pharmaceutical Group Ltd Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
CN1849142A (zh) * 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
US7044948B2 (en) 2002-12-10 2006-05-16 Sherwood Services Ag Circuit for controlling arc energy from an electrosurgical generator
US7598373B2 (en) * 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
AU2003300434A1 (en) * 2002-12-23 2004-07-22 Idenix (Cayman) Limited Process for the production of 3'-nucleoside prodrugs
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
CA2529311A1 (en) * 2003-03-28 2004-10-07 Pharmasset, Inc. Compounds for the treatment of flaviviridae infections
WO2004098385A2 (en) 2003-05-01 2004-11-18 Sherwood Services Ag Method and system for programing and controlling an electrosurgical generator system
EP2345661A1 (de) 2003-05-30 2011-07-20 Pharmasset, Inc. Modifizierte fluorinierte Nukleosidanaloga
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
US20050009848A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ltd. Use of antivirals against inflammatory bowel diseases
DK1658302T3 (da) 2003-07-25 2010-11-22 Idenix Pharmaceuticals Inc Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
CA2542798C (en) 2003-10-23 2015-06-23 Sherwood Services Ag Thermocouple measurement circuit
EP1675499B1 (de) 2003-10-23 2011-10-19 Covidien AG Redundante temperaturüberwachung für elektrochirurgische systeme zur sicherheitserhöhung
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
US7131860B2 (en) 2003-11-20 2006-11-07 Sherwood Services Ag Connector systems for electrosurgical generator
US7766905B2 (en) 2004-02-12 2010-08-03 Covidien Ag Method and system for continuity testing of medical electrodes
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
US7780662B2 (en) 2004-03-02 2010-08-24 Covidien Ag Vessel sealing system using capacitive RF dielectric heating
EP1912643A2 (de) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurinderivate zur behandlung von infektionen mit flaviviridae
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AU2005285045B2 (en) 2004-09-14 2011-10-13 Gilead Pharmasset Llc Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
WO2006074416A1 (en) * 2005-01-07 2006-07-13 Health Research Inc. 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
WO2006105440A2 (en) * 2005-03-30 2006-10-05 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
CA2618429A1 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
US8734438B2 (en) 2005-10-21 2014-05-27 Covidien Ag Circuit and method for reducing stored energy in an electrosurgical generator
US7947039B2 (en) 2005-12-12 2011-05-24 Covidien Ag Laparoscopic apparatus for performing electrosurgical procedures
EP1976382B1 (de) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Verfahren zur herstellung eines synthetischen zwischenprodukts für die herstellung von verzweigten nukleosiden
US7651493B2 (en) 2006-03-03 2010-01-26 Covidien Ag System and method for controlling electrosurgical snares
CN101511379A (zh) * 2006-03-09 2009-08-19 Om药物公司 免疫调节化合物和治疗与炎性细胞因子过度产生相关的疾病的方法
FR2907786B1 (fr) * 2006-10-27 2009-09-18 Univ Grenoble 1 Thionucleosides et applications pharmaceutiques
CN101511185A (zh) * 2006-09-11 2009-08-19 南方研究所 唑类核苷和作为rna和dna病毒聚合酶抑制剂的用途
EP2105445A4 (de) * 2006-12-08 2014-01-22 Api Corp Verfahren zur herstellung eines furanosederivats
WO2008086341A1 (en) * 2007-01-09 2008-07-17 Pericor Therapeutics, Inc. Methods. compositions, and formulations for preventing or reducing adverse effects in a patient
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
EP2185195A2 (de) * 2007-08-16 2010-05-19 Tripep Ab Immunogen-plattform
EP2200611A4 (de) 2007-09-14 2010-09-22 Biogen Idec Inc Zusammensetzungen und verfahren zur behandlung von progressiver multifokaler leukoenzephalopathie (pml)
US8227431B2 (en) 2008-03-17 2012-07-24 Hetero Drugs Limited Nucleoside derivatives
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
AU2009246926B2 (en) 2008-05-15 2014-06-26 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
AU2009329872B2 (en) 2008-12-23 2016-07-07 Gilead Pharmasset Llc Synthesis of purine nucleosides
SG172361A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside analogs
EP2408306A4 (de) * 2009-03-20 2012-11-07 Alios Biopharma Inc Substituierte nukleosid- und nukleotid-analoga
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2752422B1 (de) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselektive synthese von phosphorhaltigen wirkstoffen
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
GB201021867D0 (en) * 2010-12-23 2011-02-02 Mologen Ag Non-coding immunomodulatory DNA construct
CN102153548B (zh) * 2011-02-24 2012-11-28 河北大学 一种含有噻唑（嗪）烷酮环的类核苷衍生物及其制备方法和其在药物制剂中的应用
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine
AU2012302051B2 (en) 2011-08-30 2017-04-27 Astex Pharmaceuticals, Inc. Decitabine derivative formulations
MD4589C1 (ro) 2011-09-16 2019-03-31 Gilead Pharmasset Llc Compoziţie farmaceutică cu conţinut de sofosbuvir şi utilizarea acesteia în tratamentul hepatitei virale C
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2794630A4 (de) 2011-12-22 2015-04-01 Alios Biopharma Inc Substituierte phosphorthioat-nukleotidanaloga
UY34536A (es) 2011-12-22 2013-07-31 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN104321333A (zh) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 硫代氨基磷酸酯核苷酸前药的固体形式
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
UY34824A (es) 2012-05-25 2013-11-29 Janssen R & D Ireland Nucleósidos de espirooxetano de uracilo
KR102168621B1 (ko) 2012-12-21 2020-10-22 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
NZ625087A (en) 2013-01-31 2017-05-26 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
US20140309164A1 (en) 2013-04-12 2014-10-16 Achillion Pharmaceuticals, Inc. Deuterated nucleoside prodrugs useful for treating hcv
ES2900570T3 (es) 2013-08-27 2022-03-17 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
SG11201602595TA (en) 2013-10-11 2016-04-28 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EP3092001B1 (de) 2014-01-07 2020-10-07 Babita Agrawal Immunmodulierende zusammensetzungen und verfahren zur verwendung davon
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
RU2016149767A (ru) 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
JP2017520545A (ja) 2014-07-02 2017-07-27 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
US10273305B2 (en) 2015-04-02 2019-04-30 Ablynx N.V. Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity
EP3316685A4 (de) 2015-07-02 2019-03-13 Otsuka Pharmaceutical Co., Ltd. Lyophilisierte pharmazeutische zusammensetzungen
LU92821B1 (en) 2015-09-09 2017-03-20 Mologen Ag Combination comprising immunostimulatory oligonucleotides
GB2542425A (en) 2015-09-21 2017-03-22 Mologen Ag Means for the treatment of HIV
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
RU2624018C2 (ru) * 2016-09-26 2017-06-30 Федеральное государственное бюджетное учреждение науки Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН (ИБХ РАН) Амид 5-(тетрагидрофуран-2-ил)-1,2,4-триазол-3-карбоновой кислоты, обладающий противовирусной активностью, и способ его получения
WO2019025863A2 (en) 2017-08-03 2019-02-07 Otsuka Pharmaceutical Co., Ltd. MEDICAMENT COMPOUND AND METHODS OF PURIFICATION
WO2020157694A1 (en) * 2019-02-01 2020-08-06 Janssen Biopharma, Inc. Antiviral nucleosides and derivatives thereof
IL293592A (en) 2019-12-06 2022-08-01 Vertex Pharma Transduced tetrahydrofurans as sodium channel modulators
EP4347031A1 (de) 2021-06-04 2024-04-10 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl(hetero)aryl)tetrahydrofurancarboxamide als modulatoren von natriumkanälen
WO2023288047A2 (en) * 2021-07-15 2023-01-19 Alnylam Pharmaceuticals, Inc. Multiplexing targeting ligands through click chemistry at the anomeric site of sugars

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3948885A (en) * 1973-03-19 1976-04-06 Icn Pharmaceuticals, Inc. 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside
US4138547A (en) * 1977-12-22 1979-02-06 Icn Pharmaceuticals, Inc. Process for preparing 1,2,4-triazole nucleosides
EP0054432B1 (de) * 1980-12-15 1990-01-31 Viratek, Inc. Verwendung von 2-Beta-D-Ribofuranosylthiazol-4-carboxamiden zur Herstellung von Medikamenten zur Behandlung von krebsartigen Tumoren
JPS60193997A (ja) * 1984-03-14 1985-10-02 Sumitomo Chem Co Ltd 新規シアノイミダゾ−ルリボヌクレオシド誘導体およびその製造法
CA1317588C (en) * 1988-02-29 1993-05-11 Tohru Ueda Imidazole derivatives, process for production thereof, and use thereof
US5082829A (en) * 1989-01-24 1992-01-21 Gensia Pharmaceuticals AICA riboside prodrugs
US4992426A (en) * 1989-02-27 1991-02-12 Nucleic Acid Research Institute Antiparasitic 5'-sulfamoyl nucleosides
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
US5248776A (en) * 1990-12-05 1993-09-28 University Of Georgia Research Foundation, Inc. Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
US5438131A (en) * 1992-09-16 1995-08-01 Bergstrom; Donald E. 3-nitropyrrole nucleoside
WO1994021658A1 (en) * 1993-03-15 1994-09-29 Kalman Thomas I Antiviral imidazolinone nucleoside derivatives
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
US5599796A (en) * 1993-12-02 1997-02-04 Emory University Treatment of urogenital cancer with boron neutron capture therapy
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
DE19518216A1 (de) * 1994-10-07 1996-04-11 Max Delbrueck Centrum Neue ß-L-Nucleoside und ihre Verwendung
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5672594A (en) * 1994-10-24 1997-09-30 Genencor International, Inc. L-erythrosyl nucleosides
IT1281498B1 (it) * 1995-06-07 1998-02-18 Sardinian Antiviral Research C Pirazolo - derivati ad attivita' antitumorale, processo per la loro preparazione e composizioni farmaceutiche che li contengono , e
PT1132393E (pt) * 1996-10-16 2003-08-29 Ribapharm Inc L-ribavirina e usos da mesma

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AU4986797A (en) 1998-05-11
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YU18799A (sh) 2002-06-19
NO991785L (no) 1999-06-15
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PT1027359E (pt) 2003-09-30
EP1027359A2 (de) 2000-08-16
UA63915C2 (uk) 2004-02-16
US20020095033A1 (en) 2002-07-18
ATE236921T1 (de) 2003-04-15
HK1038365A1 (en) 2002-03-15
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EP1027359A4 (de) 2001-07-25
RU2001132536A (ru) 2003-08-20
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