DE69722258D1 - Neue verbindungen nutlich als neuroschützende mittel - Google Patents
Neue verbindungen nutlich als neuroschützende mittelInfo
- Publication number
- DE69722258D1 DE69722258D1 DE69722258T DE69722258T DE69722258D1 DE 69722258 D1 DE69722258 D1 DE 69722258D1 DE 69722258 T DE69722258 T DE 69722258T DE 69722258 T DE69722258 T DE 69722258T DE 69722258 D1 DE69722258 D1 DE 69722258D1
- Authority
- DE
- Germany
- Prior art keywords
- new
- protective agent
- connections useful
- useful
- new connections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2756096P | 1996-10-07 | 1996-10-07 | |
| US27560P | 1996-10-07 | ||
| PCT/US1997/017963 WO1998015274A1 (en) | 1996-10-07 | 1997-10-06 | Novel compounds useful as neuro-protective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69722258D1 true DE69722258D1 (de) | 2003-06-26 |
| DE69722258T2 DE69722258T2 (de) | 2004-03-18 |
Family
ID=21838447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69722258T Expired - Fee Related DE69722258T2 (de) | 1996-10-07 | 1997-10-06 | Neue verbindungen nutlich als neuroschützende mittel |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6156748A (de) |
| EP (1) | EP0971709B1 (de) |
| CN (1) | CN1239889A (de) |
| AT (1) | ATE240728T1 (de) |
| AU (1) | AU721355B2 (de) |
| CA (1) | CA2270661A1 (de) |
| CZ (1) | CZ166399A3 (de) |
| DE (1) | DE69722258T2 (de) |
| DK (1) | DK0971709T3 (de) |
| EA (1) | EA001713B1 (de) |
| ES (1) | ES2199353T3 (de) |
| HU (1) | HUP9904682A3 (de) |
| ID (1) | ID21472A (de) |
| IL (1) | IL129748A (de) |
| NO (1) | NO313193B1 (de) |
| NZ (1) | NZ335610A (de) |
| PT (1) | PT971709E (de) |
| TR (1) | TR199901559T2 (de) |
| WO (1) | WO1998015274A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| US5942530A (en) * | 1997-08-28 | 1999-08-24 | Eli Lilly And Company | Method for treating pain |
| EP0908180A3 (de) * | 1997-08-28 | 1999-04-21 | Eli Lilly And Company | Verwendung von Phenyloxazol oder Phenylthiazol Derivaten zur Behandlung von Schmerzen |
| BR9812857A (pt) * | 1997-10-06 | 2000-08-08 | Lilly Co Eli | Compostos úteis como agentes neuro-protetores |
| IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| WO2001021577A2 (en) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| FR2812546B1 (fr) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| TWI283577B (en) * | 1999-10-11 | 2007-07-11 | Sod Conseils Rech Applic | Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof |
| WO2001082925A1 (fr) | 2000-04-28 | 2001-11-08 | Takeda Chemical Industries, Ltd. | Antagonistes de l'hormone concentrant la melanine |
| EP1358175A2 (de) * | 2001-02-08 | 2003-11-05 | Karo Bio Ab | Phenoxysubstituierte benzokondensierte heteroarylderivate als thyroidrezeptor-liganden |
| US7091357B2 (en) * | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
| AU2003267980A1 (en) | 2002-07-03 | 2004-01-23 | Janssen Pharmaceutica, N.V. | Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders |
| EP2491943B1 (de) | 2003-02-04 | 2018-10-10 | Cornell Research Foundation, Inc. | Verfahren zum Verhindern des Übergangs der Mitochondrienpermeabilität |
| TW200505913A (en) | 2003-03-28 | 2005-02-16 | Hoffmann La Roche | Novel oxazole derivatives, their manufacture and use as pharmaceutical agents |
| US7353897B2 (en) * | 2003-07-23 | 2008-04-08 | Fernandez Dennis S | Telematic method and apparatus with integrated power source |
| JP4931604B2 (ja) | 2004-01-23 | 2012-05-16 | コーネル リサーチ ファウンデイション インコーポレイテッド | 酸化的損傷を低減する方法 |
| USRE46792E1 (en) | 2005-11-15 | 2018-04-17 | Otsuka Pharmaceutical Co., Ltd. | Oxazole compound and pharmaceutical composition |
| WO2012031719A1 (de) | 2010-09-06 | 2012-03-15 | Arys Gmbh | Betankbarer akku |
| WO2016179369A1 (en) | 2015-05-07 | 2016-11-10 | Impact Labs Llc | Device for minimizing impact of collisions for a helmet |
| WO2024040267A2 (en) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
| DE3425118A1 (de) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
| GB8531608D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Group Plc | Treatment |
| DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0382199A1 (de) * | 1989-02-08 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Oxazol-Verbindungen und ihre Verwendung |
| DE3903993A1 (de) * | 1989-02-10 | 1990-08-16 | Basf Ag | Diarylsubstituierte heterocyclische verbindungen, ihre herstellung und arzneimittel daraus |
| KR100221041B1 (ko) * | 1990-11-30 | 1999-09-15 | 야스이 쇼사꾸 | 2-아릴티아졸 유도체 및 그의 약제학적 조성물 |
| US5633271A (en) * | 1992-05-26 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Arthropodicidal oxazolines and thiazolines |
| DE4304197A1 (de) * | 1993-02-12 | 1994-08-18 | Bayer Ag | Substituierte Oxazole |
| US5428048A (en) * | 1993-11-08 | 1995-06-27 | American Home Products Corporation | Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| US5952360A (en) * | 1997-08-28 | 1999-09-14 | Eli Lilly And Company | Method for treating neuropathic pain |
| US5942530A (en) * | 1997-08-28 | 1999-08-24 | Eli Lilly And Company | Method for treating pain |
| EP0908180A3 (de) * | 1997-08-28 | 1999-04-21 | Eli Lilly And Company | Verwendung von Phenyloxazol oder Phenylthiazol Derivaten zur Behandlung von Schmerzen |
| BR9812857A (pt) * | 1997-10-06 | 2000-08-08 | Lilly Co Eli | Compostos úteis como agentes neuro-protetores |
-
1997
- 1997-10-06 WO PCT/US1997/017963 patent/WO1998015274A1/en not_active Application Discontinuation
- 1997-10-06 AT AT97909975T patent/ATE240728T1/de not_active IP Right Cessation
- 1997-10-06 DE DE69722258T patent/DE69722258T2/de not_active Expired - Fee Related
- 1997-10-06 AU AU47459/97A patent/AU721355B2/en not_active Ceased
- 1997-10-06 TR TR1999/01559T patent/TR199901559T2/xx unknown
- 1997-10-06 ES ES97909975T patent/ES2199353T3/es not_active Expired - Lifetime
- 1997-10-06 NZ NZ335610A patent/NZ335610A/xx unknown
- 1997-10-06 US US08/944,468 patent/US6156748A/en not_active Expired - Fee Related
- 1997-10-06 EP EP97909975A patent/EP0971709B1/de not_active Expired - Lifetime
- 1997-10-06 CN CN97180378A patent/CN1239889A/zh active Pending
- 1997-10-06 IL IL12974897A patent/IL129748A/xx not_active IP Right Cessation
- 1997-10-06 HU HU9904682A patent/HUP9904682A3/hu unknown
- 1997-10-06 DK DK97909975T patent/DK0971709T3/da active
- 1997-10-06 CZ CZ991663A patent/CZ166399A3/cs unknown
- 1997-10-06 CA CA002270661A patent/CA2270661A1/en not_active Abandoned
- 1997-10-06 EA EA199900362A patent/EA001713B1/ru not_active IP Right Cessation
- 1997-10-06 ID IDW990301A patent/ID21472A/id unknown
- 1997-10-06 PT PT97909975T patent/PT971709E/pt unknown
-
1999
- 1999-05-07 NO NO19992226A patent/NO313193B1/no not_active IP Right Cessation
- 1999-08-04 US US09/368,236 patent/US6166216A/en not_active Expired - Fee Related
-
2000
- 2000-11-17 US US09/715,987 patent/US6380213B1/en not_active Expired - Fee Related
-
2001
- 2001-11-28 US US09/996,005 patent/US6423709B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TR199901559T2 (xx) | 1999-09-21 |
| IL129748A (en) | 2003-11-23 |
| AU721355B2 (en) | 2000-06-29 |
| EA199900362A1 (ru) | 2000-02-28 |
| US20020065274A1 (en) | 2002-05-30 |
| NZ335610A (en) | 2000-10-27 |
| CZ166399A3 (cs) | 1999-11-17 |
| ES2199353T3 (es) | 2004-02-16 |
| WO1998015274A1 (en) | 1998-04-16 |
| EP0971709A4 (de) | 2001-04-11 |
| NO992226D0 (no) | 1999-05-07 |
| CA2270661A1 (en) | 1998-04-16 |
| NO992226L (no) | 1999-05-27 |
| DE69722258T2 (de) | 2004-03-18 |
| IL129748A0 (en) | 2000-02-29 |
| NO313193B1 (no) | 2002-08-26 |
| HUP9904682A3 (en) | 2001-09-28 |
| US6380213B1 (en) | 2002-04-30 |
| EP0971709B1 (de) | 2003-05-21 |
| ID21472A (id) | 1999-06-17 |
| DK0971709T3 (da) | 2003-09-22 |
| CN1239889A (zh) | 1999-12-29 |
| PT971709E (pt) | 2003-09-30 |
| US6156748A (en) | 2000-12-05 |
| US6166216A (en) | 2000-12-26 |
| ATE240728T1 (de) | 2003-06-15 |
| EA001713B1 (ru) | 2001-08-27 |
| EP0971709A1 (de) | 2000-01-19 |
| HUP9904682A2 (hu) | 2000-05-28 |
| AU4745997A (en) | 1998-05-05 |
| US6423709B1 (en) | 2002-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |