DE69726272D1 - Thienopyridinsulfonamidderivate, verwandte verbindungen zur modulierung der endothelinaktivität - Google Patents
Thienopyridinsulfonamidderivate, verwandte verbindungen zur modulierung der endothelinaktivitätInfo
- Publication number
- DE69726272D1 DE69726272D1 DE69726272T DE69726272T DE69726272D1 DE 69726272 D1 DE69726272 D1 DE 69726272D1 DE 69726272 T DE69726272 T DE 69726272T DE 69726272 T DE69726272 T DE 69726272T DE 69726272 D1 DE69726272 D1 DE 69726272D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- endothelin
- thienopyridine
- inactivity
- related compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/632,586 US5804585A (en) | 1996-04-15 | 1996-04-15 | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
PCT/US1997/005994 WO1997039000A1 (en) | 1996-04-15 | 1997-04-09 | Thieno-pyridine sulfonamides, derivatives thereof and related compounds that modulate the activity of endothelin |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69726272D1 true DE69726272D1 (de) | 2003-12-24 |
Family
ID=24536121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69726272T Expired - Lifetime DE69726272D1 (de) | 1996-04-15 | 1997-04-09 | Thienopyridinsulfonamidderivate, verwandte verbindungen zur modulierung der endothelinaktivität |
Country Status (6)
Country | Link |
---|---|
US (4) | US5804585A (de) |
EP (1) | EP0898571B1 (de) |
AT (1) | ATE254619T1 (de) |
AU (1) | AU2664197A (de) |
DE (1) | DE69726272D1 (de) |
WO (1) | WO1997039000A1 (de) |
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US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
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US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
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US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
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ES2241133T3 (es) | 1997-04-28 | 2005-10-16 | Encysive Pharmaceuticals Inc. | Sulfamidas para el tratamiento de los trastornos inducidos por la endotelina. |
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WO2001049289A1 (en) * | 1999-12-31 | 2001-07-12 | Texas Biotechnology Corporation | Pharmaceutical and veterinary uses of endothelin antagonists |
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CN102603581B (zh) * | 2005-06-22 | 2015-06-24 | 普莱希科公司 | 作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物 |
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WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
PE20081581A1 (es) * | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
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MA34948B1 (fr) | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
JP5382053B2 (ja) * | 2011-04-15 | 2014-01-08 | 株式会社安川電機 | ロボットシステムおよびロボットシステムを用いた検査方法 |
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GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
CN113874015A (zh) | 2018-12-21 | 2021-12-31 | 细胞基因公司 | Ripk2的噻吩并吡啶抑制剂 |
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-
1996
- 1996-04-15 US US08/632,586 patent/US5804585A/en not_active Expired - Fee Related
-
1997
- 1997-04-09 AT AT97918564T patent/ATE254619T1/de not_active IP Right Cessation
- 1997-04-09 DE DE69726272T patent/DE69726272D1/de not_active Expired - Lifetime
- 1997-04-09 EP EP97918564A patent/EP0898571B1/de not_active Expired - Lifetime
- 1997-04-09 WO PCT/US1997/005994 patent/WO1997039000A1/en active IP Right Grant
- 1997-04-09 AU AU26641/97A patent/AU2664197A/en not_active Abandoned
-
1998
- 1998-09-04 US US09/148,643 patent/US6013655A/en not_active Expired - Fee Related
-
1999
- 1999-11-17 US US09/441,643 patent/US6329387B2/en not_active Expired - Fee Related
-
2001
- 2001-06-15 US US09/881,869 patent/US6545014B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20010014684A1 (en) | 2001-08-16 |
US5804585A (en) | 1998-09-08 |
ATE254619T1 (de) | 2003-12-15 |
WO1997039000A1 (en) | 1997-10-23 |
US6013655A (en) | 2000-01-11 |
AU2664197A (en) | 1997-11-07 |
US6545014B2 (en) | 2003-04-08 |
EP0898571B1 (de) | 2003-11-19 |
US6329387B2 (en) | 2001-12-11 |
EP0898571A1 (de) | 1999-03-03 |
US20020028829A1 (en) | 2002-03-07 |
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