DE69729803D1 - Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren - Google Patents
Sulfonamide und ihre derivate, die die aktivität des endothelins modulierenInfo
- Publication number
- DE69729803D1 DE69729803D1 DE69729803T DE69729803T DE69729803D1 DE 69729803 D1 DE69729803 D1 DE 69729803D1 DE 69729803 T DE69729803 T DE 69729803T DE 69729803 T DE69729803 T DE 69729803T DE 69729803 D1 DE69729803 D1 DE 69729803D1
- Authority
- DE
- Germany
- Prior art keywords
- endotheline
- sulphonamides
- derivatives
- activity
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US721183 | 1996-09-27 | ||
| US08/721,183 US5962490A (en) | 1987-09-25 | 1996-09-27 | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| PCT/US1997/017402 WO1998013366A1 (en) | 1996-09-27 | 1997-09-26 | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69729803D1 true DE69729803D1 (de) | 2004-08-12 |
| DE69729803T2 DE69729803T2 (de) | 2005-07-14 |
Family
ID=24896894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69729803T Expired - Lifetime DE69729803T2 (de) | 1996-09-27 | 1997-09-26 | Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US5962490A (de) |
| EP (2) | EP0946552B1 (de) |
| JP (2) | JP3743520B2 (de) |
| KR (1) | KR100372195B1 (de) |
| CN (2) | CN1215069C (de) |
| AP (1) | AP9901471A0 (de) |
| AT (1) | ATE270669T1 (de) |
| AU (1) | AU736269B2 (de) |
| BR (1) | BR9711550A (de) |
| CA (1) | CA2261760C (de) |
| CZ (1) | CZ85499A3 (de) |
| DE (1) | DE69729803T2 (de) |
| EA (2) | EA200300824A1 (de) |
| ES (1) | ES2224271T3 (de) |
| IL (1) | IL128145A0 (de) |
| NO (1) | NO991388L (de) |
| NZ (1) | NZ334797A (de) |
| OA (1) | OA11024A (de) |
| PL (1) | PL332323A1 (de) |
| PT (1) | PT946552E (de) |
| SK (1) | SK36599A3 (de) |
| TR (1) | TR199900705T2 (de) |
| WO (1) | WO1998013366A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| PL197843B1 (pl) * | 1997-04-28 | 2008-05-30 | Encysive Pharmaceuticals Inc | Farmaceutycznie dopuszczalne sole metali alkalicznych ze związkami sulfonoamidowymi, środek farmaceutyczny, zastosowanie farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi, sposób wytwarzania liofilizowanego proszku i sposób wytwarzania farmaceutycznie dopuszczalnych soli metali alkalicznych ze związkami sulfonoamidowymi |
| EP1533311B1 (de) * | 1999-12-31 | 2007-04-25 | Encysive Pharmaceuticals, Inc | Sulfonamide und deren Derivate als Modulatoren der Endothelin-Aktivität |
| AU2464301A (en) | 1999-12-31 | 2001-07-16 | Encysive Pharmaceuticals Inc. | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| US20030152956A1 (en) * | 2000-12-26 | 2003-08-14 | Noriko Ohtani | Method of examining allergic disease |
| EP1243263B1 (de) * | 2001-03-21 | 2002-11-27 | Schwarz Pharma Ag | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
| US20030176356A1 (en) * | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
| RS44304A (en) * | 2001-11-22 | 2007-06-04 | Biovitrum Ab., | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
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| EP1461333A1 (de) * | 2001-11-22 | 2004-09-29 | Biovitrum Ab | Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1 |
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| RU2321394C2 (ru) * | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
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| US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
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| US20050113566A1 (en) * | 2003-04-25 | 2005-05-26 | Player Mark R. | Inhibitors of C-FMS kinase |
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-
1996
- 1996-09-27 US US08/721,183 patent/US5962490A/en not_active Expired - Lifetime
-
1997
- 1997-09-26 US US08/938,325 patent/US6420567B1/en not_active Expired - Fee Related
- 1997-09-26 KR KR10-1999-7002629A patent/KR100372195B1/ko not_active IP Right Cessation
- 1997-09-26 IL IL12814597A patent/IL128145A0/xx unknown
- 1997-09-26 EP EP97943629A patent/EP0946552B1/de not_active Expired - Lifetime
- 1997-09-26 AP APAP/P/1999/001471A patent/AP9901471A0/en unknown
- 1997-09-26 EA EA200300824A patent/EA200300824A1/ru unknown
- 1997-09-26 CN CNB971983437A patent/CN1215069C/zh not_active Expired - Lifetime
- 1997-09-26 AU AU45059/97A patent/AU736269B2/en not_active Ceased
- 1997-09-26 NZ NZ334797A patent/NZ334797A/en unknown
- 1997-09-26 PT PT97943629T patent/PT946552E/pt unknown
- 1997-09-26 EA EA199900294A patent/EA004146B1/ru not_active IP Right Cessation
- 1997-09-26 CZ CZ99854A patent/CZ85499A3/cs unknown
- 1997-09-26 EP EP03007240A patent/EP1342721A1/de not_active Withdrawn
- 1997-09-26 AT AT97943629T patent/ATE270669T1/de not_active IP Right Cessation
- 1997-09-26 WO PCT/US1997/017402 patent/WO1998013366A1/en not_active Application Discontinuation
- 1997-09-26 ES ES97943629T patent/ES2224271T3/es not_active Expired - Lifetime
- 1997-09-26 CA CA002261760A patent/CA2261760C/en not_active Expired - Lifetime
- 1997-09-26 CN CNB031584780A patent/CN100558724C/zh not_active Expired - Lifetime
- 1997-09-26 DE DE69729803T patent/DE69729803T2/de not_active Expired - Lifetime
- 1997-09-26 JP JP51597998A patent/JP3743520B2/ja not_active Expired - Lifetime
- 1997-09-26 SK SK365-99A patent/SK36599A3/sk unknown
- 1997-09-26 TR TR1999/00705T patent/TR199900705T2/xx unknown
- 1997-09-26 BR BR9711550-9A patent/BR9711550A/pt not_active IP Right Cessation
- 1997-09-26 PL PL97332323A patent/PL332323A1/xx unknown
-
1999
- 1999-03-12 OA OA9900058A patent/OA11024A/en unknown
- 1999-03-22 US US09/274,280 patent/US6331637B1/en not_active Expired - Fee Related
- 1999-03-22 NO NO991388A patent/NO991388L/no unknown
-
2001
- 2001-11-05 US US10/011,610 patent/US6632829B2/en not_active Expired - Fee Related
-
2002
- 2002-04-03 JP JP2002101613A patent/JP2002308875A/ja active Pending
-
2003
- 2003-05-28 US US10/447,763 patent/US20030208084A1/en not_active Abandoned
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