DE69731758D1 - O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2-diolate - Google Patents
O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2-diolateInfo
- Publication number
- DE69731758D1 DE69731758D1 DE69731758T DE69731758T DE69731758D1 DE 69731758 D1 DE69731758 D1 DE 69731758D1 DE 69731758 T DE69731758 T DE 69731758T DE 69731758 T DE69731758 T DE 69731758T DE 69731758 D1 DE69731758 D1 DE 69731758D1
- Authority
- DE
- Germany
- Prior art keywords
- diolate
- ium
- substituted
- diazene
- glycosyiate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/08—Azoxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2681696P | 1996-09-27 | 1996-09-27 | |
US26816P | 1996-09-27 | ||
US4591797P | 1997-05-07 | 1997-05-07 | |
US45917P | 1997-05-07 | ||
US5169697P | 1997-07-03 | 1997-07-03 | |
US51696P | 1997-07-03 | ||
PCT/US1997/017267 WO1998013358A1 (en) | 1996-09-27 | 1997-09-26 | O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69731758D1 true DE69731758D1 (de) | 2004-12-30 |
DE69731758T2 DE69731758T2 (de) | 2005-12-15 |
Family
ID=27362853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69731758T Expired - Lifetime DE69731758T2 (de) | 1996-09-27 | 1997-09-26 | O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2-diolate |
Country Status (7)
Country | Link |
---|---|
US (3) | US6610660B1 (de) |
EP (2) | EP2292630B1 (de) |
AT (1) | ATE283267T1 (de) |
AU (1) | AU733590B2 (de) |
CA (2) | CA2705474C (de) |
DE (1) | DE69731758T2 (de) |
WO (1) | WO1998013358A1 (de) |
Families Citing this family (48)
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FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
US7678391B2 (en) | 2000-04-26 | 2010-03-16 | Queen's University At Kingston | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
EP1278547B1 (de) | 2000-04-26 | 2004-11-03 | Cellegy Pharmaceuticals, Inc | Formulierungen und verfahren zur verwendung von stickstoffmonoxid mimetika gegen einen malignen zellphänotyp |
EP1276865B1 (de) * | 2000-04-28 | 2014-05-21 | Sangamo BioSciences, Inc. | Verfahren zur bindung eines exogenen moleküls an zelluläres chromatin |
WO2001092215A2 (en) * | 2000-06-02 | 2001-12-06 | Us Health | Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same |
WO2002041902A1 (en) * | 2000-11-27 | 2002-05-30 | The University Of Akron | Treatment of disorders using polyethylenimine diazeniumdiolate |
WO2003080039A1 (en) | 2002-03-21 | 2003-10-02 | The University Of Utah Research Foundation | In vivo use of glutathionone s-transferase activated nitric oxide donors |
AU2003234510A1 (en) | 2002-05-07 | 2003-11-11 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Healt | Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same |
JP2005534485A (ja) | 2002-08-02 | 2005-11-17 | アメリカ合衆国 | 架橋した一酸化窒素−放出ポリアミン被覆基質、それを含む組成物及びその製造方法 |
WO2005011575A2 (en) * | 2003-07-25 | 2005-02-10 | The University Of Akron | Stabilization and ionic triggering of nitric oxide release |
WO2005074598A2 (en) * | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
US7569559B2 (en) * | 2004-02-09 | 2009-08-04 | Noxilizer, Inc. | Nitric oxide-releasing molecules |
CA2555591C (en) * | 2004-02-09 | 2011-01-04 | Amulet Pharmaceuticals, Inc. | Nitric oxide-releasing polymers |
JP2007534389A (ja) * | 2004-04-29 | 2007-11-29 | キューブ・メディカル・アクティーゼルスカブ | 血管形成に用いるバルーン |
WO2005112954A1 (en) * | 2004-05-14 | 2005-12-01 | William Marsh Rice University | Nitric oxide releasing compositions and associated methods |
WO2006037105A2 (en) | 2004-09-27 | 2006-04-06 | Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services | Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof |
JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
JP2009505727A (ja) | 2005-08-25 | 2009-02-12 | メドトロニック ヴァスキュラー インコーポレイテッド | 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー |
CA2628055C (en) * | 2005-10-31 | 2013-10-01 | Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services | Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates |
JP2009518516A (ja) * | 2005-12-06 | 2009-05-07 | アミュレット ファーマシューティカルズ インコーポレイティッド | 一酸化窒素放出ポリマー |
CA2650383A1 (en) * | 2006-04-24 | 2007-11-08 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health & Human Services | Diazeniumdiolated non-steroidal anti-inflammatory drugs, compositions thereof, and related methods |
US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
US7811600B2 (en) * | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
FR2916757B1 (fr) * | 2007-05-30 | 2009-07-17 | Servier Lab | Nouveaux derives diazeniumdiolates,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US8273828B2 (en) * | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
US20090222088A1 (en) * | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
CN102014870A (zh) | 2008-03-07 | 2011-04-13 | 犹他州大学研究基金会 | 活性的一氧化氮供体及其制备和应用的方法 |
US20090232863A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
US20090232868A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
US8852640B2 (en) * | 2008-07-03 | 2014-10-07 | Ecole Polytechnique Federale De Lausanne (Epfl) | Micelles for delivery of nitric oxide |
US8158187B2 (en) * | 2008-12-19 | 2012-04-17 | Medtronic Vascular, Inc. | Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices |
US8709465B2 (en) * | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
CN102695528B (zh) | 2009-08-21 | 2016-07-13 | 诺万公司 | 创伤敷料、其使用方法及其形成方法 |
CA3062005C (en) | 2009-08-21 | 2022-02-15 | Novan, Inc. | Topical gels comprising nitric oxide-releasing polysiloxane macromolecules and uses thereof |
AU2010319398B2 (en) * | 2009-11-13 | 2014-06-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer |
EP2533644B1 (de) * | 2010-02-12 | 2017-01-18 | Merck Sharp & Dohme Corp. | Diazeniumdiolat-cyclopentyl- derivate |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
ES2695173T3 (es) | 2011-02-28 | 2019-01-02 | Novan Inc | Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas |
US9187501B2 (en) | 2012-08-28 | 2015-11-17 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing nanorods and their methods of use |
EP3131994B1 (de) * | 2014-04-16 | 2021-06-09 | Sika Technology AG | Schnell härtende migrationsfreie zusammensetzung auf basis von silangruppen-haltigen organischen polymeren |
WO2016015095A1 (en) * | 2014-07-31 | 2016-02-04 | The University Of Western Australia | A method for the identification of immunotherapy-drug combinations using a network approach |
JP6661289B2 (ja) * | 2015-07-08 | 2020-03-11 | 三星ディスプレイ株式會社Samsung Display Co.,Ltd. | 有機エレクトロルミネッセンス素子用材料及びそれを用いた有機エレクトロルミネッセンス素子 |
WO2017075460A1 (en) * | 2015-10-29 | 2017-05-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Skin-like condoms having active ingredients to enhance a male erection and a female arousal |
US11186681B2 (en) | 2016-10-07 | 2021-11-30 | The University Of North Carolina At Chapel Hill | S-Nitrosothiol-mediated hyperbranched polyesters |
CA3048785A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
CA3055474A1 (en) | 2017-03-28 | 2018-10-04 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
AU2019231712A1 (en) | 2018-03-06 | 2020-10-15 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11421044B2 (en) | 2018-12-28 | 2022-08-23 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto |
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US4954526A (en) | 1989-02-28 | 1990-09-04 | The United States Of America As Represented By The Department Of Health And Human Services | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents |
US5208233A (en) | 1989-09-15 | 1993-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
US5212204A (en) | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
US5155137A (en) | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
AU668107B2 (en) | 1991-09-24 | 1996-04-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
US5389675A (en) | 1992-03-27 | 1995-02-14 | The United States Of America As Represented By The Department Of Health And Human Services | Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents |
US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US5525357A (en) | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5691423A (en) | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5700830A (en) * | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
-
1997
- 1997-09-26 CA CA2705474A patent/CA2705474C/en not_active Expired - Lifetime
- 1997-09-26 CA CA2266908A patent/CA2266908C/en not_active Expired - Lifetime
- 1997-09-26 AU AU45957/97A patent/AU733590B2/en not_active Expired
- 1997-09-26 EP EP10010885.1A patent/EP2292630B1/de not_active Expired - Lifetime
- 1997-09-26 WO PCT/US1997/017267 patent/WO1998013358A1/en active IP Right Grant
- 1997-09-26 US US09/254,301 patent/US6610660B1/en not_active Expired - Lifetime
- 1997-09-26 AT AT97944471T patent/ATE283267T1/de not_active IP Right Cessation
- 1997-09-26 DE DE69731758T patent/DE69731758T2/de not_active Expired - Lifetime
- 1997-09-26 EP EP97944471A patent/EP0929538B1/de not_active Expired - Lifetime
-
2003
- 2003-01-07 US US10/337,495 patent/US6911433B2/en not_active Expired - Lifetime
-
2005
- 2005-04-12 US US11/104,232 patent/US7081524B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6610660B1 (en) | 2003-08-26 |
DE69731758T2 (de) | 2005-12-15 |
EP2292630B1 (de) | 2015-11-25 |
EP0929538A1 (de) | 1999-07-21 |
ATE283267T1 (de) | 2004-12-15 |
AU4595797A (en) | 1998-04-17 |
CA2705474C (en) | 2013-07-16 |
US7081524B2 (en) | 2006-07-25 |
EP2292630A1 (de) | 2011-03-09 |
CA2705474A1 (en) | 1998-04-02 |
US20030147845A1 (en) | 2003-08-07 |
AU733590B2 (en) | 2001-05-17 |
WO1998013358A1 (en) | 1998-04-02 |
US20050214249A1 (en) | 2005-09-29 |
CA2266908C (en) | 2010-07-20 |
EP0929538B1 (de) | 2004-11-24 |
CA2266908A1 (en) | 1998-04-02 |
US6911433B2 (en) | 2005-06-28 |
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