DE69736814D1 - Adipogenische differenzierung von humanen mesenchymalen stammzellen - Google Patents

Adipogenische differenzierung von humanen mesenchymalen stammzellen

Info

Publication number
DE69736814D1
DE69736814D1 DE69736814T DE69736814T DE69736814D1 DE 69736814 D1 DE69736814 D1 DE 69736814D1 DE 69736814 T DE69736814 T DE 69736814T DE 69736814 T DE69736814 T DE 69736814T DE 69736814 D1 DE69736814 D1 DE 69736814D1
Authority
DE
Germany
Prior art keywords
mesenchymal stem
stem cells
differentiate
cells
human mesenchymal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69736814T
Other languages
English (en)
Other versions
DE69736814T2 (de
Inventor
F Pittenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osiris Therapeutics Inc
Original Assignee
Osiris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osiris Therapeutics Inc filed Critical Osiris Therapeutics Inc
Application granted granted Critical
Publication of DE69736814D1 publication Critical patent/DE69736814D1/de
Publication of DE69736814T2 publication Critical patent/DE69736814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
DE69736814T 1996-07-30 1997-07-21 Adipogenische differenzierung von humanen mesenchymalen stammzellen Expired - Lifetime DE69736814T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US700753 1996-07-30
US08/700,753 US5827740A (en) 1996-07-30 1996-07-30 Adipogenic differentiation of human mesenchymal stem cells
PCT/US1997/012356 WO1998004682A1 (en) 1996-07-30 1997-07-21 Adipogenic differentiation of human mesenchymal stem cells

Publications (2)

Publication Number Publication Date
DE69736814D1 true DE69736814D1 (de) 2006-11-23
DE69736814T2 DE69736814T2 (de) 2007-08-16

Family

ID=24814738

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736814T Expired - Lifetime DE69736814T2 (de) 1996-07-30 1997-07-21 Adipogenische differenzierung von humanen mesenchymalen stammzellen

Country Status (11)

Country Link
US (3) US5827740A (de)
EP (2) EP1659172A1 (de)
JP (1) JP2001523084A (de)
AT (1) ATE342349T1 (de)
AU (1) AU3729097A (de)
CA (1) CA2262014C (de)
DE (1) DE69736814T2 (de)
DK (1) DK0954565T3 (de)
ES (1) ES2274547T3 (de)
PT (1) PT954565E (de)
WO (1) WO1998004682A1 (de)

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EP0954565A1 (de) 1999-11-10
US6709864B1 (en) 2004-03-23
EP0954565A4 (de) 2002-09-18
US6322784B1 (en) 2001-11-27
AU3729097A (en) 1998-02-20
PT954565E (pt) 2007-01-31
CA2262014C (en) 2010-09-14
ES2274547T3 (es) 2007-05-16
EP1659172A1 (de) 2006-05-24
DE69736814T2 (de) 2007-08-16
EP0954565B1 (de) 2006-10-11
WO1998004682A1 (en) 1998-02-05
US5827740A (en) 1998-10-27
ATE342349T1 (de) 2006-11-15
DK0954565T3 (da) 2007-02-05
JP2001523084A (ja) 2001-11-20

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