DE69738206D1 - DNA-Diagnostik mittels Massenspektrometrie - Google Patents

DNA-Diagnostik mittels Massenspektrometrie

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Publication number
DE69738206D1
DE69738206D1 DE69738206T DE69738206T DE69738206D1 DE 69738206 D1 DE69738206 D1 DE 69738206D1 DE 69738206 T DE69738206 T DE 69738206T DE 69738206 T DE69738206 T DE 69738206T DE 69738206 D1 DE69738206 D1 DE 69738206D1
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Germany
Prior art keywords
branching
well
sub
outlet
branch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738206T
Other languages
English (en)
Other versions
DE69738206T2 (de
Inventor
Hubert Koester
Daniel P Little
Andreas Braun
Christian Jurinke
Den Boom Dirk Van
Guobing Xiang
David M Lough
Andreas Ruppert
Franz Hillenkamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/744,590 external-priority patent/US6074823A/en
Priority claimed from US08/746,036 external-priority patent/US5900481A/en
Priority claimed from US08/744,481 external-priority patent/US6428955B1/en
Priority claimed from US08/787,639 external-priority patent/US6024925A/en
Priority claimed from US08/786,988 external-priority patent/US7285422B1/en
Priority claimed from US08/933,792 external-priority patent/US6133436A/en
Application filed by Sequenom Inc filed Critical Sequenom Inc
Application granted granted Critical
Publication of DE69738206D1 publication Critical patent/DE69738206D1/de
Publication of DE69738206T2 publication Critical patent/DE69738206T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • G01N2035/1069—Multiple transfer devices for transfer to or from containers having different spacing by adjusting the spacing between multiple probes of a single transferring head
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
DE69738206T 1996-11-06 1997-11-06 DNA-Diagnostik mittels Massenspektrometrie Expired - Lifetime DE69738206T2 (de)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US74605596A 1996-11-06 1996-11-06
US746055 1996-11-06
US08/744,590 US6074823A (en) 1993-03-19 1996-11-06 DNA sequencing by mass spectrometry via exonuclease degradation
US746036 1996-11-06
US744481 1996-11-06
US08/746,036 US5900481A (en) 1996-11-06 1996-11-06 Bead linkers for immobilizing nucleic acids to solid supports
US744590 1996-11-06
US08/744,481 US6428955B1 (en) 1995-03-17 1996-11-06 DNA diagnostics based on mass spectrometry
US08/787,639 US6024925A (en) 1997-01-23 1997-01-23 Systems and methods for preparing low volume analyte array elements
US08/786,988 US7285422B1 (en) 1997-01-23 1997-01-23 Systems and methods for preparing and analyzing low volume analyte array elements
US786988 1997-01-23
US787639 1997-01-23
US08/933,792 US6133436A (en) 1996-11-06 1997-09-19 Beads bound to a solid support and to nucleic acids
US933792 1997-09-19
US94780197A 1997-10-08 1997-10-08
US947801 1997-10-08

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CA2270132A1 (en) 1998-05-14
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US7501251B2 (en) 2009-03-10
NO992168L (no) 1999-07-06
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US7198893B1 (en) 2007-04-03
AU735416B2 (en) 2001-07-05
US20070202514A1 (en) 2007-08-30
EP1164203B1 (de) 2007-10-10
NO992168D0 (no) 1999-05-04
US20030129589A1 (en) 2003-07-10
US20020042112A1 (en) 2002-04-11
HK1043158A1 (zh) 2002-09-06
EP0954612A2 (de) 1999-11-10
WO1998020166A3 (en) 1998-10-22
US20090023150A1 (en) 2009-01-22
ATE375403T1 (de) 2007-10-15
DE19782095T1 (de) 2000-03-23
EP1164203A3 (de) 2002-03-13

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