DE69821376D1 - Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht - Google Patents

Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Info

Publication number
DE69821376D1
DE69821376D1 DE69821376T DE69821376T DE69821376D1 DE 69821376 D1 DE69821376 D1 DE 69821376D1 DE 69821376 T DE69821376 T DE 69821376T DE 69821376 T DE69821376 T DE 69821376T DE 69821376 D1 DE69821376 D1 DE 69821376D1
Authority
DE
Germany
Prior art keywords
molecular weight
low molecular
active substances
fold
intermediate active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69821376T
Other languages
English (en)
Inventor
M Vicik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of DE69821376D1 publication Critical patent/DE69821376D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
DE69821376T 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht Expired - Lifetime DE69821376D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/946,839 US20020052026A1 (en) 1997-10-08 1997-10-08 Methods of refolding proteins
PCT/US1998/017499 WO1999018196A1 (en) 1997-10-08 1998-08-24 Methods of refolding proteins by use of zwitterionic low molecular weight agents

Publications (1)

Publication Number Publication Date
DE69821376D1 true DE69821376D1 (de) 2004-03-04

Family

ID=25485053

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69821376T Expired - Lifetime DE69821376D1 (de) 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Country Status (8)

Country Link
US (5) US20020052026A1 (de)
EP (1) EP1021528B1 (de)
JP (1) JP2001519149A (de)
AT (1) ATE258598T1 (de)
AU (1) AU757692B2 (de)
CA (1) CA2305559A1 (de)
DE (1) DE69821376D1 (de)
WO (1) WO1999018196A1 (de)

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DE19755960C1 (de) * 1997-12-16 1998-11-26 Hoechst Ag Verfahren zum Aufschluß von biologischem Material
FR2801219A1 (fr) * 2000-09-18 2001-05-25 Pf Medicament Procede de preparation de proteine recombinante renaturee en presence de detergent
EP1314739A1 (de) * 2001-11-22 2003-05-28 Bayer Ag Verfahren zur Renaturierung rekombinanter, Disulfid-enthaltender Proteine bei hohen Proteinkonzentrationen in Gegenwart von Aminen
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
EP2364718B1 (de) 2002-02-14 2016-07-06 The Board of Trustees of the Leland Stanford Junior University Enzymbehandlung von Nahrungsmitteln für Zöliakie
JP4401618B2 (ja) 2002-04-15 2010-01-20 キヤノン株式会社 記録装置、及び、バッファ管理方法
SI21273A (sl) * 2002-07-31 2004-02-29 LEK farmacevtska dru�ba d.d. Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
DK1563300T3 (da) 2002-11-20 2012-07-23 Univ Leland Stanford Junior Diagnostisk fremgangsmåde til cøliaki
EP1449848A1 (de) * 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604964D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Protein folding
US8778338B2 (en) * 2007-03-16 2014-07-15 The Board Of Trustees Of The Leland Stanford Junior University Combination enzyme therapy for digestion of dietary gluten
WO2008115428A2 (en) * 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University A scaleable manufacturing process for cysteine endoprotease b, isoform 2
CA2692585A1 (en) * 2007-07-03 2010-01-04 Amgen Inc. Measurement of protein using inclusion body dry weight
EP3660032A1 (de) 2009-06-25 2020-06-03 Amgen, Inc Erfassungs-/reinigungsverfahren für in einem nichtsäugersystem exprimierte proteine
JPWO2012029148A1 (ja) 2010-09-01 2013-10-28 株式会社オステオファーマ 組換えヒト骨形成タンパク質−２凍結乾燥製剤
US9630916B2 (en) 2014-08-19 2017-04-25 Wisconsin Alumni Research Foundation Organocatalysts of oxidative protein folding
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
WO2021050009A2 (en) * 2019-09-13 2021-03-18 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof

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AU597924B2 (en) * 1985-12-11 1990-06-14 Natinco Nv Solubilization of protein aggregates
US5106748A (en) 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
ATE209251T1 (de) 1990-05-16 2001-12-15 Genetics Inst Knochen- und knorpel-bildung hervorrufende proteine
EP0592562B1 (de) 1991-06-25 1999-01-07 Genetics Institute, Inc. Bmp-9 zusammensetzungen
RU2208638C2 (ru) 1992-02-12 2003-07-20 Биофарм Гезельшафт Цур Биотехнологишен Энтвиклунг фон Фармака мбХ Днк (варианты), способ получения белка, белок, фармацевтическая композиция
DE4208568A1 (de) 1992-03-18 1993-09-23 Zimmer Ag Verfahren und vorrichtung zur herstellung synthetischer endlosfilamente
IL106278A0 (en) 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
CA2153652A1 (en) 1993-01-12 1994-07-21 Se-Jin Lee Growth differentiation factor-3
JP3645258B2 (ja) 1993-01-12 2005-05-11 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−５
CA2153653C (en) 1993-01-12 2010-12-07 Se-Jin Lee Growth differentiation factor-9
ES2201076T3 (es) 1993-03-19 2004-03-16 The Johns Hopkins University School Of Medicine Factor-8 de diferenciacion del crecimiento.
AU677849B2 (en) 1993-05-12 1997-05-08 Genetics Institute, Llc BMP-10 compositions
EP0698094B1 (de) 1993-05-12 2004-02-04 Genetics Institute, LLC Bmp-11 zusammensetzungen
AU688779B2 (en) 1993-07-09 1998-03-19 Johns Hopkins University School Of Medicine, The Growth differentiation factor-7
US5770444A (en) 1993-07-09 1998-06-23 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5407810A (en) * 1993-08-20 1995-04-18 Genentech, Inc. Aqueous multiple-phase isolation of polypeptide
US6204047B1 (en) 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
ES2255059T3 (es) 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
FR2714906B1 (fr) 1994-01-12 1996-02-02 Commissariat Energie Atomique Agents de solubilisation de biomolécules constitués par des zwitterions non détergents et leurs utilisations.
JPH07250688A (ja) 1994-01-28 1995-10-03 Sagami Chem Res Center ＴＧＦ−βスーパーファミリー蛋白質をコードするヒト新規ｃＤＮＡ
EP0776337B1 (de) 1994-07-08 2005-09-21 The Johns Hopkins University School Of Medicine Wachstums-differenzierungsfaktor-11
EP0770089B1 (de) 1994-07-13 2000-09-06 The Johns Hopkins University School Of Medicine Wachstumsdifferenzierungsfaktor-12
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions

Also Published As

Publication number Publication date
EP1021528A1 (de) 2000-07-26
US6593106B1 (en) 2003-07-15
EP1021528B1 (de) 2004-01-28
CA2305559A1 (en) 1999-04-15
JP2001519149A (ja) 2001-10-23
US20020052026A1 (en) 2002-05-02
AU9116798A (en) 1999-04-27
US6632635B1 (en) 2003-10-14
WO1999018196A1 (en) 1999-04-15
AU757692B2 (en) 2003-03-06
US6593107B1 (en) 2003-07-15
US6596511B1 (en) 2003-07-22
ATE258598T1 (de) 2004-02-15

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