DE69837537D1 - Methoden zur messung zellulärer vermehrungs- und abbauraten in vitro und in vivo - Google Patents
Methoden zur messung zellulärer vermehrungs- und abbauraten in vitro und in vivoInfo
- Publication number
- DE69837537D1 DE69837537D1 DE69837537T DE69837537T DE69837537D1 DE 69837537 D1 DE69837537 D1 DE 69837537D1 DE 69837537 T DE69837537 T DE 69837537T DE 69837537 T DE69837537 T DE 69837537T DE 69837537 D1 DE69837537 D1 DE 69837537D1
- Authority
- DE
- Germany
- Prior art keywords
- abortionates
- vitro
- vivo
- methods
- measuring cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US857007 | 1992-03-25 | ||
US08/857,007 US5910403A (en) | 1997-05-15 | 1997-05-15 | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
PCT/US1998/009479 WO1998051820A1 (en) | 1997-05-15 | 1998-05-08 | METHODS FOR MEASURING CELLULAR PROLIFERATION AND DESTRUCTION RATES IN VITRO AND $i(IN VIVO) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69837537D1 true DE69837537D1 (de) | 2007-05-24 |
DE69837537T2 DE69837537T2 (de) | 2007-12-20 |
Family
ID=25324953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69837537T Expired - Lifetime DE69837537T2 (de) | 1997-05-15 | 1998-05-08 | Methoden zur messung zellulärer vermehrungs- und abbauraten in vitro und in vivo |
Country Status (10)
Country | Link |
---|---|
US (6) | US5910403A (de) |
EP (1) | EP0980441B1 (de) |
JP (1) | JP4510942B2 (de) |
AT (1) | ATE359375T1 (de) |
AU (1) | AU737119B2 (de) |
CA (1) | CA2287781C (de) |
DE (1) | DE69837537T2 (de) |
DK (1) | DK0980441T3 (de) |
HK (1) | HK1026004A1 (de) |
WO (1) | WO1998051820A1 (de) |
Families Citing this family (52)
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AU745236B2 (en) | 1997-02-14 | 2002-03-14 | George Washington University, The | An assay for the measurement of DNA synthesis rates |
US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
WO2000013025A1 (en) * | 1998-08-31 | 2000-03-09 | University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
AU774662B2 (en) | 1999-04-20 | 2004-07-01 | Target Discovery, Inc. | Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database |
US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
EP1305595A2 (de) | 2000-06-22 | 2003-05-02 | Clinomics Laboratories, Inc. | Mikroarrays aus eingefrorenem gewebe und verfahren zu ihrer verwendung |
US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
AU2002338345A1 (en) * | 2001-04-04 | 2002-10-21 | Digital Gene Technologies, Inc. | Genes expressed in intestinal epithelium and peyer's patch m cells |
US7256047B2 (en) * | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
EP1419389A4 (de) * | 2001-07-25 | 2005-04-06 | Univ North Carolina | Verfahren und vorrichtung zur schnellen bestimmung der ligand-protein-bindung unter verwendung von aktivkohleadsorption |
US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
IL161498A0 (en) * | 2001-10-24 | 2004-09-27 | Univ California | Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water |
CA2475924C (en) * | 2002-02-12 | 2016-03-29 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
US20030180800A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
US20030224420A1 (en) * | 2002-04-05 | 2003-12-04 | Hellerstein Marc K. | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
EP1539929B1 (de) * | 2002-06-28 | 2013-04-10 | Life Technologies Corporation | Verfahren zur wiederherstellung des immunrepertoirs in patienten mit immunologischen defekten in verbindung mit autoimmunität sowie transplantation von organen oder hämatopoetischen stammzellen |
US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
CA2494715C (en) * | 2002-07-30 | 2014-07-08 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates using mass spectrometry |
DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Hermann Heye I Ins Fa | Pressstempelmechanismus einer Glasformmaschine |
JP2005537490A (ja) * | 2002-09-03 | 2005-12-08 | ニューロノバ エービー | 生体分子、細胞、組織、器官および生物体の逆算的な、誕生齢決定のための方法 |
AU2003268416A1 (en) * | 2002-09-04 | 2004-03-29 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
DK1546373T3 (da) * | 2002-09-13 | 2009-03-30 | Univ California | Fremgangsmåder til måling af hastigheder af revers cholesteroltransport in vivo som et indeks for antiatherogenese |
AU2003275037A1 (en) * | 2002-09-16 | 2004-04-30 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
AU2005222430A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
US20050255509A1 (en) * | 2004-03-30 | 2005-11-17 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
US20100092962A1 (en) * | 2004-07-07 | 2010-04-15 | Alexandre Loktionov | Method of Detecting Colorectal Cancer |
EP1824516A4 (de) * | 2004-10-29 | 2008-11-05 | Target Discovery Inc | Glycan-analyse mit deuterierter glucose |
JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
JP2009506789A (ja) * | 2005-09-06 | 2009-02-19 | キナメッド・インコーポレイテッド | リンパ組織におけるリンパ増殖、クローン拡大、動員および輸送ならびにそれらに対する抗原および調整剤のインビボ作用を定量するためのキネティックバイオマーカー |
US20070156347A1 (en) * | 2005-12-30 | 2007-07-05 | Searete Llc | Using a biological recording to obtain time values |
US8150628B2 (en) * | 2005-12-30 | 2012-04-03 | The Invention Science Fund I, Llc | Establishing a biological recording timeline by artificial marking |
US20070156345A1 (en) * | 2005-12-30 | 2007-07-05 | Hyde Roderick A | Modulating a biological recording with another biological recording |
CN102099687A (zh) | 2008-05-21 | 2011-06-15 | 金尼医疗公司 | 使用调节剂治疗运动神经元疾病的组合物和方法 |
EP2753707A4 (de) | 2011-09-08 | 2015-03-04 | Univ California | Metabolische flussmessung, abbildung und mikroskopie |
ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
AU2013334526B2 (en) * | 2012-10-25 | 2018-06-14 | Run Them Sweet, LLC | Methods and systems to estimate nutritional needs of human and other patients and to support such nutritional needs |
US9808031B2 (en) | 2012-10-25 | 2017-11-07 | Run Them Sweet Llc | Systems and methods to estimate nutritional needs of human and other patients |
US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
AU2014232869A1 (en) | 2013-03-15 | 2015-10-08 | Patrizia Fanara | Methods for monitoring the effects of an agent in sujects with motoneuron disease with dementia |
US9883524B2 (en) * | 2015-11-04 | 2018-01-30 | Huawei Technologies Co., Ltd. | Systems and methods for configuring air interfaces with low overhead |
CN111239353A (zh) * | 2020-01-19 | 2020-06-05 | 辉源生物科技(上海)有限公司 | 一种人源柠檬酸转运蛋白抑制剂化合物的筛选方法 |
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DK1546373T3 (da) * | 2002-09-13 | 2009-03-30 | Univ California | Fremgangsmåder til måling af hastigheder af revers cholesteroltransport in vivo som et indeks for antiatherogenese |
AU2003275037A1 (en) | 2002-09-16 | 2004-04-30 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
WO2004042360A2 (en) | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
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US7262020B2 (en) | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
AU2005222430A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
US20050255509A1 (en) * | 2004-03-30 | 2005-11-17 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
1997
- 1997-05-15 US US08/857,007 patent/US5910403A/en not_active Expired - Lifetime
-
1998
- 1998-05-08 DK DK98921082T patent/DK0980441T3/da active
- 1998-05-08 AU AU73767/98A patent/AU737119B2/en not_active Expired
- 1998-05-08 CA CA002287781A patent/CA2287781C/en not_active Expired - Lifetime
- 1998-05-08 DE DE69837537T patent/DE69837537T2/de not_active Expired - Lifetime
- 1998-05-08 JP JP54933998A patent/JP4510942B2/ja not_active Expired - Lifetime
- 1998-05-08 AT AT98921082T patent/ATE359375T1/de not_active IP Right Cessation
- 1998-05-08 US US09/075,309 patent/US6010846A/en not_active Expired - Lifetime
- 1998-05-08 WO PCT/US1998/009479 patent/WO1998051820A1/en active IP Right Grant
- 1998-05-08 EP EP98921082A patent/EP0980441B1/de not_active Expired - Lifetime
-
1999
- 1999-11-15 US US09/440,596 patent/US6461806B1/en not_active Expired - Lifetime
-
2000
- 2000-08-23 HK HK00105293A patent/HK1026004A1/xx not_active IP Right Cessation
-
2002
- 2002-05-24 US US10/155,536 patent/US6808875B2/en not_active Expired - Lifetime
-
2004
- 2004-09-16 US US10/944,154 patent/US7022834B2/en not_active Expired - Lifetime
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2005
- 2005-07-19 US US11/185,610 patent/US20060008796A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU737119B2 (en) | 2001-08-09 |
AU7376798A (en) | 1998-12-08 |
US20050053992A1 (en) | 2005-03-10 |
DK0980441T3 (da) | 2007-09-03 |
US6010846A (en) | 2000-01-04 |
WO1998051820A1 (en) | 1998-11-19 |
JP2001527558A (ja) | 2001-12-25 |
US6808875B2 (en) | 2004-10-26 |
HK1026004A1 (en) | 2000-12-01 |
US7022834B2 (en) | 2006-04-04 |
US20030068634A1 (en) | 2003-04-10 |
CA2287781C (en) | 2008-11-18 |
ATE359375T1 (de) | 2007-05-15 |
EP0980441A1 (de) | 2000-02-23 |
DE69837537T2 (de) | 2007-12-20 |
US6461806B1 (en) | 2002-10-08 |
CA2287781A1 (en) | 1998-11-19 |
EP0980441B1 (de) | 2007-04-11 |
US20060008796A1 (en) | 2006-01-12 |
US5910403A (en) | 1999-06-08 |
JP4510942B2 (ja) | 2010-07-28 |
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