DE69839557D1 - Klonierte genome von infektiösen hepatitis c viren und deren verwendungen - Google Patents

Klonierte genome von infektiösen hepatitis c viren und deren verwendungen

Info

Publication number
DE69839557D1
DE69839557D1 DE69839557T DE69839557T DE69839557D1 DE 69839557 D1 DE69839557 D1 DE 69839557D1 DE 69839557 T DE69839557 T DE 69839557T DE 69839557 T DE69839557 T DE 69839557T DE 69839557 D1 DE69839557 D1 DE 69839557D1
Authority
DE
Germany
Prior art keywords
viruses
infectious hepatitis
cloned genome
sequences
hcv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839557T
Other languages
English (en)
Inventor
Masayuki Yanagi
Jens Bukh
Suzanne U Emerson
Robert H Purcell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69839557D1 publication Critical patent/DE69839557D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
DE69839557T 1997-07-18 1998-07-16 Klonierte genome von infektiösen hepatitis c viren und deren verwendungen Expired - Lifetime DE69839557D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5306297P 1997-07-18 1997-07-18
US09/014,416 US6153421A (en) 1997-07-18 1998-01-27 Cloned genomes of infectious hepatitis C viruses and uses thereof
PCT/US1998/014688 WO1999004008A2 (en) 1997-07-18 1998-07-16 Cloned genomes of infectious hepatitis c viruses and uses thereof

Publications (1)

Publication Number Publication Date
DE69839557D1 true DE69839557D1 (de) 2008-07-10

Family

ID=26686065

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839557T Expired - Lifetime DE69839557D1 (de) 1997-07-18 1998-07-16 Klonierte genome von infektiösen hepatitis c viren und deren verwendungen

Country Status (7)

Country Link
US (3) US6153421A (de)
EP (1) EP0998567B1 (de)
AT (1) ATE397070T1 (de)
AU (1) AU746965B2 (de)
CA (1) CA2295552C (de)
DE (1) DE69839557D1 (de)
WO (1) WO1999004008A2 (de)

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US7235394B1 (en) * 1995-08-29 2007-06-26 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US6153421A (en) * 1997-07-18 2000-11-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloned genomes of infectious hepatitis C viruses and uses thereof
EP1036847B1 (de) * 1999-02-03 2004-10-27 Ortho-Clinical Diagnostics, Inc. Oligonukleotid Primer zur effizienten reversen Transkription von Hepatitis C Virus (HCV) RNS und Verfahren zu deren Verwendung
DE19915178A1 (de) * 1999-04-03 2000-10-05 Univ Mainz Johannes Gutenberg Hepatitis C Virus Zellkultursystem
AU7602800A (en) * 1999-09-23 2001-04-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof
US6995299B2 (en) * 1999-11-02 2006-02-07 University Of Connecticut Propagation of human hepatocytes in non-human animals
CA2414421A1 (en) * 2000-07-31 2002-02-07 Gene Logic, Inc. Molecular toxicology modeling
US7590493B2 (en) * 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
AU2001292151B2 (en) * 2000-08-17 2006-05-04 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
RU2286172C2 (ru) * 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
GB0021859D0 (en) * 2000-09-06 2000-10-18 Imp College Innovations Ltd Methods
EP1421222A4 (de) * 2001-03-09 2004-07-07 Univ California Zellkultursystem zur synthese von infektiösem hepatitis-c-virus
FR2824072B1 (fr) * 2001-04-27 2004-03-12 Centre Nat Rech Scient Procede de replication et de production du virus de l'hepatite c
WO2002090572A2 (en) * 2001-05-09 2002-11-14 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
CA2447357A1 (en) * 2001-05-22 2002-11-28 Gene Logic, Inc. Molecular toxicology modeling
US20070015146A1 (en) * 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
AU2002365904A1 (en) * 2001-07-10 2003-09-04 Gene Logic, Inc. Cardiotoxin molecular toxicology modeling
US20070054269A1 (en) * 2001-07-10 2007-03-08 Mendrick Donna L Molecular cardiotoxicology modeling
US7447594B2 (en) * 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
CU23244A1 (es) * 2001-07-16 2007-10-17 Ct Ingenieria Genetica Biotech Formulacion vacunal potenciada por la combinacion de un adn con un antigeno
US7745418B2 (en) * 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
US6689559B2 (en) 2001-11-29 2004-02-10 The Research Foundation Of The State University Of New York Efficient hepatitis C virus replicon and its use in identifying antiviral compounds
JP2005535285A (ja) * 2002-01-31 2005-11-24 ジーン ロジック インコーポレイテッド 分子肝毒性モデリング
ES2321498T3 (es) * 2002-03-11 2009-06-08 Lab 21 Limited Metodos y composiciones para identificar y caracterizar la hepatitis c.
FR2848572B1 (fr) * 2002-12-12 2005-12-09 Univ Joseph Fourier Molecules inhibitrices de la synthese proteique du virus de l'hepatite c et procede de criblage desdites molecules inhibitrices
JP2007501617A (ja) * 2003-08-07 2007-02-01 ジーン ロジック インコーポレイテッド 初代ラット肝細胞毒性モデリング
US20080281526A1 (en) * 2004-03-22 2008-11-13 Diggans James C Methods For Molecular Toxicology Modeling
WO2005100989A2 (en) * 2004-04-07 2005-10-27 Gene Logic, Inc. Hepatotoxicity molecular models
ATE505541T1 (de) * 2004-09-24 2011-04-15 Alnylam Pharmaceuticals Inc Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai
ES2349153T3 (es) * 2004-09-29 2010-12-28 The Administrators Of The Tulane Educational Fund Inhibidores del virus de la hepatitis c.
WO2007031867A2 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
WO2008125117A1 (en) 2007-04-13 2008-10-23 Hvidovre Hospital Cell culture system of a hepatitis c genotype 3a and 2a chimera
US8454974B2 (en) 2007-04-13 2013-06-04 Hvidovre Hospital Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A
WO2008141651A1 (en) 2007-05-18 2008-11-27 Hvidovre Hospital Efficient cell culture system for hepatitis c virus genotype 5a
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform
US20090214593A1 (en) * 2007-08-16 2009-08-27 Tripep Ab Immunogen platform
US8563706B2 (en) 2007-12-20 2013-10-22 Hvidovre Hospital Efficient cell culture system for hepatitis C virus genotype 1A and 1B
US8569472B2 (en) 2007-12-20 2013-10-29 Hvidovre Hospital Efficient cell culture system for hepatitis C virus genotype 6A
US8323891B2 (en) * 2008-08-01 2012-12-04 Claflin University miRNA triplex formations for the downregulation of viral replication
US8506969B2 (en) 2008-08-15 2013-08-13 Hvidovre Hospital Efficient cell culture system for hepatitis C virus genotype 7a
WO2010017818A1 (en) 2008-08-15 2010-02-18 Hvidovre Hospital Efficient cell culture system for hepatitis c virus genotype 2b
US8772022B2 (en) 2008-10-03 2014-07-08 Hvidovre Hospital Hepatitis C virus expressing reporter tagged NS5A protein
JP2012513757A (ja) * 2008-12-31 2012-06-21 アボット・ラボラトリーズ Ｃ型肝炎ウイルスの検出用プライマー及びプローブ
JP2012515534A (ja) * 2009-01-21 2012-07-12 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルス核酸を増幅する方法

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Publication number Priority date Publication date Assignee Title
US5679342A (en) * 1987-11-18 1997-10-21 Chiron Corporation Hepatitis C virus infected cell systems
CA2065690A1 (en) * 1991-04-10 1992-10-11 Hiroaki Okamoto Non-a, non-b hepatitis related antigens, detection systems, polynucleotides and polypeptides
US5874565A (en) * 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US6153421A (en) * 1997-07-18 2000-11-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloned genomes of infectious hepatitis C viruses and uses thereof
US7084266B1 (en) * 1999-06-04 2006-08-01 The United States Of America As Represented By The Department Of Health And Human Services Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof

Also Published As

Publication number Publication date
EP0998567A2 (de) 2000-05-10
CA2295552A1 (en) 1999-01-28
WO1999004008A2 (en) 1999-01-28
WO1999004008A3 (en) 1999-04-01
AU8488998A (en) 1999-02-10
US6153421A (en) 2000-11-28
AU746965B2 (en) 2002-05-09
US7201911B1 (en) 2007-04-10
US7846454B2 (en) 2010-12-07
ATE397070T1 (de) 2008-06-15
US20080014212A1 (en) 2008-01-17
EP0998567B1 (de) 2008-05-28
CA2295552C (en) 2013-03-12

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