DE69840495D1 - Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben - Google Patents
Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselbenInfo
- Publication number
- DE69840495D1 DE69840495D1 DE69840495T DE69840495T DE69840495D1 DE 69840495 D1 DE69840495 D1 DE 69840495D1 DE 69840495 T DE69840495 T DE 69840495T DE 69840495 T DE69840495 T DE 69840495T DE 69840495 D1 DE69840495 D1 DE 69840495D1
- Authority
- DE
- Germany
- Prior art keywords
- deletes
- production
- pharmaceutical form
- dispersion properties
- rapid dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3828497P | 1997-02-20 | 1997-02-20 | |
US3888397P | 1997-02-20 | 1997-02-20 | |
PCT/US1998/003256 WO1998036738A1 (en) | 1997-02-20 | 1998-02-20 | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69840495D1 true DE69840495D1 (de) | 2009-03-12 |
Family
ID=26715043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69840495T Expired - Lifetime DE69840495D1 (de) | 1997-02-20 | 1998-02-20 | Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben |
Country Status (9)
Country | Link |
---|---|
US (3) | US6471992B1 (de) |
EP (1) | EP0973507B1 (de) |
JP (3) | JP4563516B2 (de) |
AT (1) | ATE421318T1 (de) |
AU (1) | AU736912B2 (de) |
CA (1) | CA2281473C (de) |
DE (1) | DE69840495D1 (de) |
ES (1) | ES2318869T3 (de) |
WO (1) | WO1998036738A1 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6471992B1 (en) * | 1997-02-20 | 2002-10-29 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
ATE348601T1 (de) * | 1998-05-18 | 2007-01-15 | Takeda Pharmaceutical | Im munde zerfallende tablette enthaltend ein benzimidazole |
US6284270B1 (en) * | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
EP1301177A2 (de) * | 2000-07-10 | 2003-04-16 | Therics, Inc. | Verfahren und materialien zur steuerung der wanderung einer binderflüssigkeit in ein pulver |
US7014867B2 (en) * | 2001-06-28 | 2006-03-21 | Ucb Farchim Sa | Tablet comprising cetirizine and pseudoephedrine |
MXPA04000209A (es) * | 2001-07-10 | 2005-03-07 | Teva Pharma | Sistema de administracion para la administracion de droga de orden cero, bifasica de orden cero, ascendente o descendente. |
EP1439945B1 (de) * | 2001-10-29 | 2006-04-12 | Therics, Inc. | System und verfahren zum uniaxialen pressen eines gegenstandes wie eine drei-dimensional gedruckte dosierungsform |
CA2463481A1 (en) * | 2001-10-29 | 2003-05-22 | Therics, Inc. | Three-dimensional suspension printing of dosage forms |
DE60323482D1 (de) * | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
MX2007003032A (es) | 2004-09-21 | 2007-05-21 | Hypnion Inc | Analogos de loxapina y metodos de uso de los mismos. |
US7829000B2 (en) * | 2005-02-25 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Core-shell solid freeform fabrication |
US8187659B2 (en) | 2006-05-02 | 2012-05-29 | Jerry Robertson Real Estate Llc | Solid medicament dosage form consumption aid |
DK2041071T3 (da) | 2006-06-29 | 2014-09-01 | Kinex Pharmaceuticals Llc | Biarylsammensætninger og fremgangsmåder til modulering af en kinasekaskade |
WO2009051848A1 (en) | 2007-10-20 | 2009-04-23 | Kinex Pharmaceuticals, Llc | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
DK3254676T3 (en) | 2009-10-30 | 2019-03-11 | Ix Biopharma Ltd | QUICK-SOLVING SOLID DOSAGE FORM |
EP3195858B1 (de) * | 2010-04-03 | 2019-08-07 | Praful Doshi | Medizinische vorrichtungen mit medikamenten sowie verfahren zu ihrer herstellung und verwendung |
US8692001B2 (en) | 2010-10-27 | 2014-04-08 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of PKM2 |
WO2012088438A1 (en) | 2010-12-22 | 2012-06-28 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
US8722636B2 (en) | 2011-01-31 | 2014-05-13 | New Market Pharmaceuticals, LLC | Animal treatments |
WO2012122370A2 (en) | 2011-03-08 | 2012-09-13 | Eutropics Pharmaceuticals, Inc. | Compositions and methods useful for treating diseases |
ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
WO2012160447A1 (en) | 2011-05-25 | 2012-11-29 | Dynamix Pharmaceuticals Ltd. | 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases |
DK2718290T3 (en) | 2011-06-07 | 2016-08-15 | Clevexel Pharma | Compositions and Methods for Modulating a Kinase |
ITMI20111718A1 (it) | 2011-09-23 | 2013-03-24 | Probiotical Spa | Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali. |
US9245061B2 (en) * | 2012-04-25 | 2016-01-26 | Shapeways, Inc. | Weight-based identification of three dimensional printed parts |
WO2013165468A1 (en) | 2012-05-02 | 2013-11-07 | New Market Pharmaceuticals | Pharmaceutical compositions for direct systemic introduction |
IN2014DN11205A (de) | 2012-06-20 | 2015-10-02 | Eutropics Pharmaceuticals Inc | |
CN109999040A (zh) | 2012-08-30 | 2019-07-12 | 阿西纳斯公司 | 蛋白质酪氨酸激酶调节剂 |
US9545376B2 (en) | 2013-01-23 | 2017-01-17 | Arx, Llc | Production of unit dose constructs |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
ES2688880T3 (es) * | 2013-03-15 | 2018-11-07 | Aprecia Pharmaceuticals LLC | Forma de dosificación de dispersión rápida que contiene levetiracetam |
WO2014144661A1 (en) * | 2013-03-15 | 2014-09-18 | Aprecia Pharmaceuticals Compny | Rapidly dispersible dosage form of topiramate |
EP2968354B1 (de) * | 2013-03-15 | 2019-11-13 | Aprecia Pharmaceuticals LLC | Schnell zerfallende darreichungsform von oxcarbazepin |
WO2014176389A1 (en) | 2013-04-24 | 2014-10-30 | Temple University - Of The Commonwealth System Of Higher Education | Solid dosage form containing arabinogalactan |
ITMI20130793A1 (it) | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti. |
US10471497B2 (en) | 2013-08-16 | 2019-11-12 | The Exone Company | Three-dimensional printed metal-casting molds and methods for making the same |
US20160243621A1 (en) | 2013-10-17 | 2016-08-25 | The Exone Company | Three-Dimensional Printed Hot Isostatic Pressing Containers and Processes for Making Same |
EP3086921B1 (de) * | 2013-12-23 | 2019-07-31 | The Exone Company | Verfahren und systeme zum dreidimensionalen drucken unter verwendung einer bindemittelflüssigkeit mit ausgestrahlten partikeln |
EP3086922B1 (de) | 2013-12-23 | 2022-03-09 | The Exone Company | Verfahren zum dreidimensionalen drucken unter verwendung eines mehrkomponentigen konstruktionspulvers |
US20160332373A1 (en) | 2013-12-23 | 2016-11-17 | The Exone Company | Methods and Systems for Three-Dimensional Printing Utilizing Multiple Binder Fluids |
EP3137113A4 (de) * | 2014-04-30 | 2017-03-22 | Blaesi, Aron H. | Schmelzverarbeitete polymere zelluläre darreichungsform |
EP3148730A1 (de) | 2014-05-29 | 2017-04-05 | The Exone Company | Verfahren zur herstellung von superlegierungsartikeln auf nickelbasis durch dreidimensionales drucken |
WO2016011098A2 (en) | 2014-07-17 | 2016-01-21 | The Exone Company | Methods and apparatuses for curing three-dimensional printed articles |
CN107249567B (zh) | 2014-11-21 | 2021-08-03 | 拜尔哈文制药股份有限公司 | 利鲁唑的舌下给药 |
WO2016089618A1 (en) | 2014-12-03 | 2016-06-09 | The Exone Company | Process for making densified carbon articles by three dimensional printing |
KR20180014778A (ko) | 2015-06-03 | 2018-02-09 | 트리아스텍 인코포레이티드 | 제형 및 이의 용도 |
EP3108874A1 (de) * | 2015-06-26 | 2016-12-28 | TRB Chemedica AG | Pharmazeutische zubereitung zur anwendung am auge |
US11129798B2 (en) * | 2016-08-19 | 2021-09-28 | Aron H. Blaesi | Fibrous dosage form |
JP2019508449A (ja) * | 2016-03-18 | 2019-03-28 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 種々の効能を有する薬物の組み合わせ |
JPWO2017175792A1 (ja) * | 2016-04-06 | 2019-02-14 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
CN107847398B (zh) | 2016-05-05 | 2019-05-07 | 南京三迭纪医药科技有限公司 | 控制释放的药物剂型 |
SG11201809669RA (en) | 2016-05-20 | 2018-11-29 | Biohaven Pharm Holding Co Ltd | Use of glutamate modulating agents with immunotherapies to treat cancer |
EP3497099B1 (de) | 2016-08-12 | 2022-03-02 | Athenex, Inc. | Biarylzusammensetzungen und verfahren zur modulierung einer kinasekaskade |
EP3529023B1 (de) | 2016-10-19 | 2022-05-25 | Shapeways, Inc. | Systeme und verfahren zur identifizierung dreidimensionaler druckobjekte |
BR112019013503A2 (pt) | 2016-12-31 | 2020-01-07 | Bioxcel Therapeutics, Inc. | Uso de dexmedetomidina sublingual para o tratamento da agitação |
WO2018156141A1 (en) * | 2017-02-24 | 2018-08-30 | Hewlett-Packard Development Company, L.P. | Three-dimensional (3d) printing a pharmaceutical tablet |
EP3592337B1 (de) | 2017-03-08 | 2023-07-05 | Cinrx Pharma, LLC | Pharmazeutische formulierungen von phloroglucinol und trimethylphloroglucinol |
US10435576B2 (en) | 2017-05-26 | 2019-10-08 | Infinite Material Solutions, Llc | Water soluble polymer compositions |
SG11202004332XA (en) | 2017-11-12 | 2020-06-29 | Biohaven Pharm Holding Co Ltd | Use of riluzole prodrugs to treat ataxias |
CN108066302B (zh) * | 2017-12-28 | 2020-09-11 | 无限极(中国)有限公司 | 一种快速分散固体制剂的制备方法及制备的快速分散固体制剂 |
US10350822B1 (en) | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
AU2019295699A1 (en) | 2018-06-27 | 2021-01-28 | Arx, Llc | Film formulations containing dexmedetomidine and methods of producing them |
AU2019359810A1 (en) | 2018-10-15 | 2021-06-03 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
EP3883546A1 (de) | 2018-11-21 | 2021-09-29 | Rosemont Pharmaceuticals Ltd | Orale topiramat-suspensionsformulierungen mit verlängerter lagerstabilität und verbesserter bioverfügbarkeit |
JP7287032B2 (ja) | 2019-03-20 | 2023-06-06 | 株式会社リコー | シート、シート積層体、医薬品、シートの製造方法、及びシート積層体の製造方法 |
EP3972567A1 (de) * | 2019-05-21 | 2022-03-30 | DFE Pharma GmbH & Co. KG | Dreidimensionales laktosepulverbettdrucken |
MX2022000709A (es) | 2019-07-19 | 2022-05-19 | Bioxcel Therapeutics Inc | Regimenes de tratamiento con dexmedetomidina no sedante. |
TWI734309B (zh) * | 2019-12-19 | 2021-07-21 | 水星生醫股份有限公司 | 滲透性噴塗製作藥錠裝置 |
JP2023533478A (ja) | 2020-06-26 | 2023-08-03 | アプレシア・ファーマスーティカルズ・エルエルシー | 内部空洞を有する迅速口内分散可能な錠剤 |
JP2023550274A (ja) | 2020-10-30 | 2023-12-01 | トリアステック インコーポレイテッド | 胃滞留型医薬剤形 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4642903A (en) | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
US5206025A (en) * | 1989-05-24 | 1993-04-27 | Rhone-Poulenc Sante | Porous pharmaceutical form and its preparation |
FR2647343B1 (fr) * | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
US5204055A (en) | 1989-12-08 | 1993-04-20 | Massachusetts Institute Of Technology | Three-dimensional printing techniques |
US5578322A (en) | 1990-11-30 | 1996-11-26 | Yamanouchi Pharmaceutical Co., Ltd. | Quick release coated preparation |
ATE131111T1 (de) | 1991-01-31 | 1995-12-15 | Texas Instruments Inc | Verfahren und vorrichtung zur rechnergesteuerten herstellung von dreidimensionalen gegenständen aus rechnerdaten. |
US5516530A (en) * | 1991-12-20 | 1996-05-14 | Pfizer Inc. | Porous shaped delivery devices and method of producing thereof |
JP2521612B2 (ja) * | 1992-05-20 | 1996-08-07 | ウエイ・ミン・フアーマシユーテイカル・マニユフアクチヤリング・カンパニー・リミテツド | 直接錠剤形成助剤 |
US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
US5380473A (en) | 1992-10-23 | 1995-01-10 | Fuisz Technologies Ltd. | Process for making shearform matrix |
DE4303846A1 (de) * | 1993-02-10 | 1994-08-11 | Merck Patent Gmbh | Verfahren zur Herstellung einer S-Ibuprofen enthaltenden Tablette |
EP0804170B1 (de) * | 1993-07-09 | 2001-11-14 | R.P. Scherer Corporation | Verfahren zur herstellung von gefriergetrockneten arzneistoffdosierungsformen |
US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
US6176874B1 (en) | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
US6280771B1 (en) | 1997-02-20 | 2001-08-28 | Therics, Inc. | Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof |
US5503785A (en) | 1994-06-02 | 1996-04-02 | Stratasys, Inc. | Process of support removal for fused deposition modeling |
US5633021A (en) | 1994-10-19 | 1997-05-27 | Bpm Technology, Inc. | Apparatus for making a three-dimensional article |
US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
US5560927A (en) * | 1995-07-28 | 1996-10-01 | Isp Investments Inc. | Co-processing method for making a free-flowing compressible powder and tablet therefrom |
US5653925A (en) * | 1995-09-26 | 1997-08-05 | Stratasys, Inc. | Method for controlled porosity three-dimensional modeling |
US6471992B1 (en) * | 1997-02-20 | 2002-10-29 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
-
1998
- 1998-02-20 US US09/027,183 patent/US6471992B1/en not_active Expired - Lifetime
- 1998-02-20 AU AU63314/98A patent/AU736912B2/en not_active Ceased
- 1998-02-20 ES ES98907531T patent/ES2318869T3/es not_active Expired - Lifetime
- 1998-02-20 DE DE69840495T patent/DE69840495D1/de not_active Expired - Lifetime
- 1998-02-20 JP JP53687898A patent/JP4563516B2/ja not_active Expired - Lifetime
- 1998-02-20 AT AT98907531T patent/ATE421318T1/de not_active IP Right Cessation
- 1998-02-20 CA CA002281473A patent/CA2281473C/en not_active Expired - Lifetime
- 1998-02-20 EP EP98907531A patent/EP0973507B1/de not_active Expired - Lifetime
- 1998-02-20 WO PCT/US1998/003256 patent/WO1998036738A1/en active Search and Examination
-
2002
- 2002-07-19 US US10/200,029 patent/US9463160B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 JP JP2009114753A patent/JP5091910B2/ja not_active Expired - Lifetime
- 2009-11-09 JP JP2009256374A patent/JP2010120938A/ja not_active Withdrawn
-
2012
- 2012-02-09 US US13/369,473 patent/US9114072B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2010120938A (ja) | 2010-06-03 |
US9114072B2 (en) | 2015-08-25 |
EP0973507B1 (de) | 2009-01-21 |
AU736912B2 (en) | 2001-08-02 |
EP0973507A4 (de) | 2006-08-23 |
JP4563516B2 (ja) | 2010-10-13 |
US20030133975A1 (en) | 2003-07-17 |
CA2281473A1 (en) | 1998-08-27 |
ATE421318T1 (de) | 2009-02-15 |
JP2009215305A (ja) | 2009-09-24 |
CA2281473C (en) | 2007-01-16 |
AU6331498A (en) | 1998-09-09 |
JP5091910B2 (ja) | 2012-12-05 |
ES2318869T3 (es) | 2009-05-01 |
WO1998036738A1 (en) | 1998-08-27 |
US6471992B1 (en) | 2002-10-29 |
US9463160B2 (en) | 2016-10-11 |
EP0973507A1 (de) | 2000-01-26 |
US20120207929A1 (en) | 2012-08-16 |
JP2001512488A (ja) | 2001-08-21 |
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