DE69841261D1 - Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz - Google Patents

Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz

Info

Publication number
DE69841261D1
DE69841261D1 DE69841261T DE69841261T DE69841261D1 DE 69841261 D1 DE69841261 D1 DE 69841261D1 DE 69841261 T DE69841261 T DE 69841261T DE 69841261 T DE69841261 T DE 69841261T DE 69841261 D1 DE69841261 D1 DE 69841261D1
Authority
DE
Germany
Prior art keywords
genetically modified
tumored
target bacteria
reduced virulence
mutant salmonella
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841261T
Other languages
English (en)
Inventor
David Bermudes
Kenneth B Low
Martina Ittensohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Vion Pharmaceuticals Inc
Original Assignee
Yale University
Vion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University, Vion Pharmaceuticals Inc filed Critical Yale University
Priority claimed from PCT/US1998/018701 external-priority patent/WO1999013053A1/en
Application granted granted Critical
Publication of DE69841261D1 publication Critical patent/DE69841261D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255—Salmonella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/879—Salmonella
DE69841261T 1997-09-10 1998-09-09 Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz Expired - Lifetime DE69841261D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/926,636 US6080849A (en) 1997-09-10 1997-09-10 Genetically modified tumor-targeted bacteria with reduced virulence
US09/149,832 US6447784B1 (en) 1997-09-10 1998-09-08 Genetically modified tumor-targeted bacteria with reduced virulence
PCT/US1998/018701 WO1999013053A1 (en) 1997-09-10 1998-09-09 Genetically modified tumor-targeted bacteria with reduced virulence

Publications (1)

Publication Number Publication Date
DE69841261D1 true DE69841261D1 (de) 2009-12-10

Family

ID=25453492

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69841261T Expired - Lifetime DE69841261D1 (de) 1997-09-10 1998-09-09 Genetisch modifizierte, auf tumoren gezielte bakterien mit verminderter virulenz

Country Status (5)

Country Link
US (5) US6080849A (de)
KR (1) KR20010015577A (de)
AT (1) ATE447005T1 (de)
DE (1) DE69841261D1 (de)
ZA (1) ZA988289B (de)

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US6923972B2 (en) 2005-08-02
US6447784B1 (en) 2002-09-10
US6080849A (en) 2000-06-27
US20070009489A1 (en) 2007-01-11
ZA988289B (en) 1999-03-22
ATE447005T1 (de) 2009-11-15
KR20010015577A (ko) 2001-02-26
US7514089B2 (en) 2009-04-07
US20020026655A1 (en) 2002-02-28

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