DE69909777D1 - Haftende Mikrokügelchen umfassende Zusammensetzung zur Arzneimittelgabe - Google Patents

Haftende Mikrokügelchen umfassende Zusammensetzung zur Arzneimittelgabe

Info

Publication number
DE69909777D1
DE69909777D1 DE69909777T DE69909777T DE69909777D1 DE 69909777 D1 DE69909777 D1 DE 69909777D1 DE 69909777 T DE69909777 T DE 69909777T DE 69909777 T DE69909777 T DE 69909777T DE 69909777 D1 DE69909777 D1 DE 69909777D1
Authority
DE
Germany
Prior art keywords
drug delivery
microsphere composition
adhesive microsphere
softening agent
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909777T
Other languages
English (en)
Other versions
DE69909777T2 (de
Inventor
S Cantor
Hye-Ok Choi
Joaquin Delgado
U Ko
Thu-Van Tran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co
Application granted granted Critical
Publication of DE69909777D1 publication Critical patent/DE69909777D1/de
Publication of DE69909777T2 publication Critical patent/DE69909777T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/14—Polymer mixtures characterised by other features containing polymeric additives characterised by shape
    • C08L2205/18—Spheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/28—Non-macromolecular organic substances
DE69909777T 1998-05-01 1999-03-25 Haftende Mikrokügelchen umfassende Zusammensetzung zur Arzneimittelgabe Expired - Lifetime DE69909777T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/071,667 US6312715B1 (en) 1998-05-01 1998-05-01 Adhesive microsphere drug delivery composition
PCT/US1999/006577 WO1999056782A1 (en) 1998-05-01 1999-03-25 Adhesive microsphere drug delivery composition
US71667 2002-02-08

Publications (2)

Publication Number Publication Date
DE69909777D1 true DE69909777D1 (de) 2003-08-28
DE69909777T2 DE69909777T2 (de) 2004-04-15

Family

ID=22102814

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909777T Expired - Lifetime DE69909777T2 (de) 1998-05-01 1999-03-25 Haftende Mikrokügelchen umfassende Zusammensetzung zur Arzneimittelgabe

Country Status (17)

Country Link
US (1) US6312715B1 (de)
EP (1) EP1077727B1 (de)
JP (1) JP2002513774A (de)
KR (1) KR20010043191A (de)
CN (1) CN1308548A (de)
AT (1) ATE245450T1 (de)
AU (1) AU749311B2 (de)
CA (1) CA2330863A1 (de)
DE (1) DE69909777T2 (de)
DK (1) DK1077727T3 (de)
ES (1) ES2200513T3 (de)
HU (1) HUP0101512A3 (de)
IL (1) IL139135A0 (de)
NO (1) NO20005394D0 (de)
NZ (1) NZ507631A (de)
PL (1) PL343829A1 (de)
WO (1) WO1999056782A1 (de)

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MY122454A (en) 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
KR100390870B1 (ko) * 1999-02-09 2003-07-10 주식회사 삼양사 경피투여용 항구토제 조성물 및 이를 포함하는 제제
DE19906152B4 (de) * 1999-02-10 2005-02-10 Jenapharm Gmbh & Co. Kg Wirkstoffhaltige Laminate für Transdermalsysteme
KR100393478B1 (ko) * 2000-03-29 2003-08-06 주식회사종근당 자가유화 매트릭스형 경점막·경피흡수제제
ES2240471T3 (es) * 2000-06-23 2005-10-16 Cytec Surface Specialties, S.A. Proceso para formacion de microesferas solidas de polimeros adhesivos de contacto.
AU2001292781A1 (en) * 2000-09-19 2002-04-02 National Starch And Chemical Investment Holding Corporation Acryl adhesive useful in transdermal drug delivery systems
WO2003004098A1 (en) * 2001-07-06 2003-01-16 Sucampo Ag Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
EP1894563B2 (de) 2002-05-28 2022-04-27 ratiopharm GmbH Pflaster, enthaltend Fentanylum
DE10223835A1 (de) 2002-05-28 2003-12-11 Labtec Gmbh Pflaster, enthaltend Fentanylum
AU2002329530A1 (en) * 2002-08-27 2004-03-19 Carol Choi Fung Yuen Transdermal delivery system
US20040062794A1 (en) * 2002-09-30 2004-04-01 Lee Shulman 17Beta- estradiol/levonorgestrel transdermal patch for hormone replacement therapy
KR100554162B1 (ko) * 2002-12-12 2006-02-22 한국전자통신연구원 올레아미드 또는 모노아세틸디글리세라이드가 함유된폴리(ｎ-비닐 카프로락탐) 스마트 나노 입자 및 그 제조방법
GB0302662D0 (en) * 2003-02-05 2003-03-12 Strakan Ltd Transdermal granisetron
US20060115522A1 (en) * 2003-02-17 2006-06-01 Cipla Ltd Pharmaceutical composition
US20060286158A1 (en) * 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents
US20060286159A1 (en) * 2003-10-17 2006-12-21 Calvert Murrell George A Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect
US20070053966A1 (en) * 2003-10-17 2007-03-08 Robert Ang Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue
US20070059351A1 (en) * 2003-10-17 2007-03-15 Murrell George A C Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods
US20050201959A1 (en) * 2004-03-11 2005-09-15 Vvii Newco 2003, Inc. Methods and compositions for altering skin coloration
US20070065494A1 (en) * 2005-08-03 2007-03-22 Watson Laboratories, Inc. Formulations and Methods for Enhancing the Transdermal Penetration of a Drug
US20070081962A1 (en) * 2005-10-06 2007-04-12 Amit Munshi Novel delivery of immune response modifiers for removal of chronic tattoos
EP1962795A1 (de) * 2005-12-07 2008-09-03 PharmaKodex Ltd Topische zusammensetzungen zur anwendung bei kindern
US20070202155A1 (en) * 2006-02-03 2007-08-30 Cure Therapeutics, Inc. Low dose no donor-containing transdermal patch
US20070259026A1 (en) * 2006-04-20 2007-11-08 Robert Ang Vasodialating dressing for use with intravenous catheters
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
US7645355B2 (en) * 2006-11-17 2010-01-12 3M Innovative Properties Company Method of making a microsphere transfer adhesive
WO2009073734A2 (en) 2007-12-03 2009-06-11 Medipacs, Inc. Fluid metering device
US20090155371A1 (en) 2007-12-17 2009-06-18 Sojka Milan F Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same
US8632816B2 (en) 2007-12-17 2014-01-21 Elc Management, Llc Compositions comprising solid particles entrapped in collapsed polymeric microspheres, and methods of making the same
WO2010089763A2 (en) * 2008-06-30 2010-08-12 Reliance Life Sciences Pvt. Ltd. Poly(n-vinyl caprolactam-co-acrylamide) microparticles for controlled release applications
WO2010113176A2 (en) * 2009-03-31 2010-10-07 Reliance Life Sciences Pvt. Ltd. Novel copolymers for controlled release delivery system
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
US8221994B2 (en) * 2009-09-30 2012-07-17 Cilag Gmbh International Adhesive composition for use in an immunosensor
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
JP2015510956A (ja) 2012-03-14 2015-04-13 メディパックス インコーポレイテッド 過剰反応性分子を含むスマートポリマー材料

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US4166152B1 (en) 1977-08-17 1999-05-18 Minnesota Mining & Mfg Tacky polymeric microspheres
JPS5812255A (ja) 1981-07-16 1983-01-24 Seiko Instr & Electronics Ltd ボタン型電池及びその製造方法
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
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US4737559A (en) 1986-05-19 1988-04-12 Minnesota Mining And Manufacturing Co. Pressure-sensitive adhesive crosslinked by copolymerizable aromatic ketone monomers
US4786696A (en) 1987-02-06 1988-11-22 Minnesota Mining And Manufacturing Company Process for the preparation of tacky polymeric microspheres
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US5045569A (en) 1988-11-30 1991-09-03 Minnesota Mining And Manufacturing Company Hollow acrylate polymer microspheres
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US4968562A (en) 1990-02-27 1990-11-06 Minnesota Mining And Manufacturing Company Hollow acid-free acrylate polymeric microspheres having multiple small voids
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Also Published As

Publication number Publication date
US6312715B1 (en) 2001-11-06
EP1077727A1 (de) 2001-02-28
ATE245450T1 (de) 2003-08-15
HUP0101512A2 (hu) 2002-03-28
CN1308548A (zh) 2001-08-15
EP1077727B1 (de) 2003-07-23
HUP0101512A3 (en) 2002-10-28
NO20005394L (no) 2000-10-26
CA2330863A1 (en) 1999-11-11
KR20010043191A (ko) 2001-05-25
ES2200513T3 (es) 2004-03-01
JP2002513774A (ja) 2002-05-14
DE69909777T2 (de) 2004-04-15
DK1077727T3 (da) 2003-11-10
IL139135A0 (en) 2001-11-25
PL343829A1 (en) 2001-09-10
WO1999056782A1 (en) 1999-11-11
NO20005394D0 (no) 2000-10-26
AU3115699A (en) 1999-11-23
AU749311B2 (en) 2002-06-20
NZ507631A (en) 2003-03-28

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