DE69914192T2 - Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren - Google Patents

Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren Download PDF

Info

Publication number
DE69914192T2
DE69914192T2 DE69914192T DE69914192T DE69914192T2 DE 69914192 T2 DE69914192 T2 DE 69914192T2 DE 69914192 T DE69914192 T DE 69914192T DE 69914192 T DE69914192 T DE 69914192T DE 69914192 T2 DE69914192 T2 DE 69914192T2
Authority
DE
Germany
Prior art keywords
stabilizers
stable
syrup containing
aminopolycarboxylic acids
antihistamine syrup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69914192T
Other languages
English (en)
Other versions
DE69914192D1 (de
Inventor
J Munayyer
Frank Guazzo
I Stupak
A Chaudry
A Sequeira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22209512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69914192(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69914192D1 publication Critical patent/DE69914192D1/de
Application granted granted Critical
Publication of DE69914192T2 publication Critical patent/DE69914192T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69914192T 1998-06-01 1999-05-27 Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren Expired - Lifetime DE69914192T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/088,128 US6132758A (en) 1998-06-01 1998-06-01 Stabilized antihistamine syrup
PCT/US1999/010469 WO1999062516A1 (en) 1998-06-01 1999-05-27 A stabilized antihistamine syrup containing aminopolycarboxylic acid as stabilizer

Publications (2)

Publication Number Publication Date
DE69914192D1 DE69914192D1 (de) 2004-02-19
DE69914192T2 true DE69914192T2 (de) 2004-10-21

Family

ID=22209512

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69914192T Expired - Lifetime DE69914192T2 (de) 1998-06-01 1999-05-27 Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren

Country Status (29)

Country Link
US (4) US6132758A (de)
EP (1) EP1082117B1 (de)
JP (2) JP4166948B2 (de)
AR (1) AR019147A1 (de)
AT (1) ATE257705T1 (de)
AU (1) AU754469B2 (de)
CA (1) CA2333528C (de)
CO (1) CO5011119A1 (de)
CR (1) CR6035A (de)
DE (1) DE69914192T2 (de)
DK (1) DK1082117T3 (de)
EG (1) EG23908A (de)
ES (1) ES2211192T3 (de)
GC (1) GC0000330A (de)
GT (2) GT199900072A (de)
HN (1) HN1999000081A (de)
JO (1) JO2099B1 (de)
ME (1) ME01664B (de)
MY (1) MY123325A (de)
NL (1) NL1012191C2 (de)
NO (1) NO329124B1 (de)
NZ (1) NZ508037A (de)
PA (1) PA8474201A1 (de)
PE (1) PE20000565A1 (de)
PT (1) PT1082117E (de)
RS (1) RS49609B (de)
SV (1) SV1999000068A (de)
TW (1) TW589197B (de)
WO (1) WO1999062516A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
SK287684B6 (sk) * 1999-12-20 2011-06-06 Schering Corporation Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním
AU2276801A (en) * 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
AU2277301A (en) * 1999-12-21 2001-07-03 Schering Corporation Treating allergic and inflammatory conditions
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
EP1276502A1 (de) * 2000-04-14 2003-01-22 J-Med Pharmaceuticals, Inc. Einzeldosis antihistamin/dekongestivum formulierungen zur behandlung von rhinitis
US20030216423A1 (en) * 2000-05-24 2003-11-20 Sergio Ulloa Stable liquid and solid formulations
AU2001264806A1 (en) * 2000-05-25 2001-12-03 Schering Corporation Stable liquid and solid formulations
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
IN192160B (de) * 2000-07-17 2004-02-28 Ranbaxy Lab
NZ524348A (en) * 2000-08-02 2004-07-30 Malope Company Ltd Diagnosis and treatment of non-ulcer dyspepsia based on dysfunction in the corticotropin releasing hormone (CRH) receptor and repsonse to ACTH
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
AR037131A1 (es) * 2001-10-31 2004-10-20 Schering Corp Formulaciones de jarabe de ribavirina
DE10161077A1 (de) 2001-12-12 2003-06-18 Boehringer Ingelheim Vetmed Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
US20100092562A1 (en) * 2002-11-26 2010-04-15 Hollenbeck R Gary Sustained-release drug delivery compositions and methods
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US20040229896A1 (en) * 2003-03-12 2004-11-18 Toth Zoltan G. Stable pharmaceutical compositions of desloratadine
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
US20050069590A1 (en) 2003-09-30 2005-03-31 Buehler Gail K. Stable suspensions for medicinal dosages
US7758877B2 (en) * 2004-02-05 2010-07-20 Taro Pharmaceuticals U.S.A., Inc. Stable loratadine spill resistant formulation
EP1568369A1 (de) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Verwendung von Meloxicam zur Behandlung von Atemwegserkrankungen bei Schweinen
GB0417909D0 (en) * 2004-08-11 2004-09-15 Novartis Consumer Health Sa Drop preparations
US20060093631A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods
US20070009558A1 (en) * 2004-12-22 2007-01-11 David Harris Sugar-free storage-stable antihistaminic syrups
CA2591706A1 (en) * 2004-12-22 2006-06-29 Schering Corporation Pharmaceutical formulations
US20060205752A1 (en) * 2005-03-14 2006-09-14 Keith Whitehead Stabilized hydrocodone pharmaceutical compositions with ethylenediaminetetraacetic acid
US20060275516A1 (en) * 2005-06-02 2006-12-07 Ram A N S Compositions and methods for the treatment of allergic rhinitis
MX2007016065A (es) * 2005-06-17 2008-03-10 Aft Pharmaceuticals Ltd Composicion farmaceutica novedosa y su uso en un metodo para el tratamiento de pacientes con congestion mucosal respiratoria superior.
DOP2006000274A (es) 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
EP2023957A2 (de) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Orale flüssige loratadinformulierungen und verfahren
AU2007269835A1 (en) * 2006-06-29 2008-01-10 Schering Corporation Sugar-free storage-stable antihistaminic syrups
US20080014275A1 (en) * 2006-07-13 2008-01-17 Buehler Gail K Pharmaceutical suspensions and related methods
WO2008105920A1 (en) * 2007-02-28 2008-09-04 Collegium Pharmaceutical, Inc. Antihistamine combination
EP2002733B1 (de) * 2007-06-08 2016-11-02 The Procter and Gamble Company Natürliche honighaltige Zusammensetzungen und Herstellungsverfahren dafür
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
JP5752578B2 (ja) * 2011-12-09 2015-07-22 ジェイ−メド ファーマシューティカルズ，インコーポレーティッド 鼻炎治療のための単一投与抗ヒスタミン薬／鬱血除去薬製剤
BR102012030828A2 (pt) 2012-12-03 2014-09-16 Ems Sa Composição farmacêutica compreendendo desloratadina e prednisolona e seu uso
CN104784110A (zh) * 2015-03-13 2015-07-22 浙江凯润制药有限公司 一种地氯雷他定糖浆制剂及其制备方法
RU2019109695A (ru) 2016-09-26 2020-10-26 Дзе Проктер Энд Гэмбл Компани Лекарственная форма для пролонгированного ослабления симптомов
CN109498569A (zh) * 2018-12-21 2019-03-22 湖北康源药业有限公司 一种氯雷他定糖浆及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU194864B (en) * 1984-02-15 1988-03-28 Schering Corp Process for production of 8-chlor-6,11-dihydro-11-(4-piperidilidene)-5h-benzo (5,6)-cyclo-hepta (1,2-b) pyridine and its salts
US4783465A (en) * 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
GB8618847D0 (en) * 1986-08-01 1986-09-10 Smith Kline French Lab Pharmaceutical formulations
US4975426A (en) * 1987-06-08 1990-12-04 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4829064A (en) * 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
NZ256346A (en) 1992-10-09 1997-04-24 Procter & Gamble Medicaments containing 3-l-menthoxypropane-1,2-diol for treating cold symptoms
NO941358L (no) * 1993-04-16 1994-10-17 Mcneil Ppc Inc Vandig farmasöytisk suspensjon og fremgangsmåte for fremstilling derav
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
JPH09124484A (ja) 1995-10-27 1997-05-13 Schering Purau Kk 点眼剤
US5912007A (en) * 1996-02-29 1999-06-15 Warner-Lambert Company Delivery system for the localized administration of medicaments to the upper respiratory tract and methods for preparing and using same
JP2000505104A (ja) * 1996-10-31 2000-04-25 シェーリング コーポレイション 喘息の治療のためのロラタジンおよび充血除去剤を含む組成物
US5759579A (en) * 1996-12-05 1998-06-02 American Home Products Corporation Pharmaceutical suspension systems
US5939426A (en) * 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
US6132758A (en) * 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup

Also Published As

Publication number Publication date
JO2099B1 (en) 2000-05-21
CA2333528C (en) 2002-07-02
EP1082117B1 (de) 2004-01-14
CO5011119A1 (es) 2001-02-28
DE69914192D1 (de) 2004-02-19
NO20006079D0 (no) 2000-11-30
RS49609B (sr) 2007-06-04
NO20006079L (no) 2000-11-30
ES2211192T3 (es) 2004-07-01
EP1082117A1 (de) 2001-03-14
AU4308599A (en) 1999-12-20
DK1082117T3 (da) 2004-05-03
HN1999000081A (es) 1999-08-23
JP2002516860A (ja) 2002-06-11
YU23599A (sh) 2001-07-10
PT1082117E (pt) 2004-05-31
AU754469B2 (en) 2002-11-14
GT199900072AA (es) 2000-11-16
US6514520B2 (en) 2003-02-04
NZ508037A (en) 2002-11-26
SV1999000068A (es) 2000-06-23
GC0000330A (en) 2007-03-31
US20050261280A1 (en) 2005-11-24
ME01664B (me) 2007-06-04
MY123325A (en) 2006-05-31
PE20000565A1 (es) 2000-07-05
JP2005015485A (ja) 2005-01-20
TW589197B (en) 2004-06-01
WO1999062516A1 (en) 1999-12-09
GT199900072A (es) 2000-11-16
NO329124B1 (no) 2010-08-30
US20030152595A1 (en) 2003-08-14
PA8474201A1 (es) 2001-07-31
NL1012191C2 (nl) 2000-01-04
US20020132805A1 (en) 2002-09-19
CR6035A (es) 2008-11-26
JP4166948B2 (ja) 2008-10-15
EG23908A (en) 2007-12-30
US6939550B2 (en) 2005-09-06
NL1012191A1 (nl) 1999-12-03
AR019147A1 (es) 2001-12-26
ATE257705T1 (de) 2004-01-15
US6132758A (en) 2000-10-17
CA2333528A1 (en) 1999-12-09

Similar Documents

Publication Publication Date Title
DE69914192D1 (de) Stabiler antihistaminsirup enthaltend aminopolycarbonsäuren als stabilisatoren
DE59306149D1 (de) Flüssige Antioxidantien als Stabilisatoren
FI973754A0 (fi) Foerfarande foer saendning av ett kortmeddelande i et telekommunikationsnaet
DE69909745D1 (de) Persönlichkeits orientierte internet -interaktion
DE69615360T2 (de) Stabilisatoren für lichtempfindliche säurespenderzusammensetzungen
DE59408464D1 (de) Flüssige Antioxidantien als Stabilisatoren
ID28015A (id) Peningkatan stabilitas larutan injeksi
ATE387188T1 (de) Trockene zusamensetzungen mit hydrophoben stabilisatoren
FI980293A0 (fi) Multimedia- och multiservicesamtal i ett mobiltelekommunikationsnaet
IT1310697B1 (it) Struttura di cavalletto centrale per motociclette
ATE253094T1 (de) Polimerischen stabilisatoren mit hoher affinität zur pulpen
FR2793791B1 (fr) Nouveaux composes inhibiteurs specifiques de phospholipases a2
DE59804329D1 (de) Music Browser
ID28952A (id) Prosesor sinyal reproduksi
IT249163Y1 (it) Guarnitura per cassetto
DE59806454D1 (de) Baugruppenträger
DE59812950D1 (de) Magnetbandkassettengerät
DE29900148U1 (de) CD-Rack
DE29814778U1 (de) Fahrrad-Steckblech
DE29802119U1 (de) Tragsäule
DE9414016U1 (de) Fahrrad-Tretlager
DE29818492U1 (de) Untersetzer-Kreisel
DE29804965U1 (de) Lenkerhalter
KR970003544U (ko) 수평드라이브 라이징시간보상회로
ITTO930358A0 (it) Movimento centrale per biciclette

Legal Events

Date Code Title Description
8364 No opposition during term of opposition