DE69921941D1 - Verfahren zur Herstellung von pharmazeutischen Wirkstoffpartikeln - Google Patents

Verfahren zur Herstellung von pharmazeutischen Wirkstoffpartikeln

Info

Publication number
DE69921941D1
DE69921941D1 DE69921941T DE69921941T DE69921941D1 DE 69921941 D1 DE69921941 D1 DE 69921941D1 DE 69921941 T DE69921941 T DE 69921941T DE 69921941 T DE69921941 T DE 69921941T DE 69921941 D1 DE69921941 D1 DE 69921941D1
Authority
DE
Germany
Prior art keywords
production
active pharmaceutical
pharmaceutical ingredient
ingredient particles
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69921941T
Other languages
English (en)
Other versions
DE69921941T2 (de
Inventor
Daniel Mcteigue
Indukumar G Shah
Karen Swider Lyons
David W Wynn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Consumer Inc
Original Assignee
McNeil PPC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc
Application granted granted Critical
Publication of DE69921941D1 publication Critical patent/DE69921941D1/de
Publication of DE69921941T2 publication Critical patent/DE69921941T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
DE69921941T 1998-09-04 1999-09-03 Verfahren zur Herstellung von pharmazeutischen Wirkstoffpartikeln Expired - Lifetime DE69921941T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US148251 1988-01-25
US09/148,251 US5997905A (en) 1998-09-04 1998-09-04 Preparation of pharmaceutically active particles

Publications (2)

Publication Number Publication Date
DE69921941D1 true DE69921941D1 (de) 2004-12-23
DE69921941T2 DE69921941T2 (de) 2005-12-01

Family

ID=22524956

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69921941T Expired - Lifetime DE69921941T2 (de) 1998-09-04 1999-09-03 Verfahren zur Herstellung von pharmazeutischen Wirkstoffpartikeln

Country Status (9)

Country Link
US (2) US5997905A (de)
EP (1) EP1000615B1 (de)
JP (1) JP2000109426A (de)
CN (1) CN1151844C (de)
AU (1) AU773833B2 (de)
BR (1) BR9904039A (de)
CA (1) CA2281420C (de)
DE (1) DE69921941T2 (de)
ES (1) ES2233003T3 (de)

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Also Published As

Publication number Publication date
DE69921941T2 (de) 2005-12-01
ES2233003T3 (es) 2005-06-01
BR9904039A (pt) 2001-01-16
JP2000109426A (ja) 2000-04-18
US5997905A (en) 1999-12-07
EP1000615A2 (de) 2000-05-17
EP1000615A3 (de) 2000-05-31
CN1151844C (zh) 2004-06-02
AU4735099A (en) 2000-03-16
CN1249950A (zh) 2000-04-12
EP1000615B1 (de) 2004-11-17
CA2281420C (en) 2008-11-18
US6149943A (en) 2000-11-21
CA2281420A1 (en) 2000-03-04
AU773833B2 (en) 2004-06-10

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN