DE69925461D1 - Zielgerichtete abgabe von biologische-aktive medien - Google Patents

Zielgerichtete abgabe von biologische-aktive medien

Info

Publication number
DE69925461D1
DE69925461D1 DE69925461T DE69925461T DE69925461D1 DE 69925461 D1 DE69925461 D1 DE 69925461D1 DE 69925461 T DE69925461 T DE 69925461T DE 69925461 T DE69925461 T DE 69925461T DE 69925461 D1 DE69925461 D1 DE 69925461D1
Authority
DE
Germany
Prior art keywords
gas
filled
formulations
site
substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69925461T
Other languages
English (en)
Other versions
DE69925461T2 (de
Inventor
Michel Schneider
Feng Yan
Agnes Hiver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Research SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Research SA filed Critical Bracco Research SA
Publication of DE69925461D1 publication Critical patent/DE69925461D1/de
Application granted granted Critical
Publication of DE69925461T2 publication Critical patent/DE69925461T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
DE69925461T 1998-02-09 1999-02-02 Zielgerichtete abgabe von biologische-aktive medien Expired - Lifetime DE69925461T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98810095 1998-02-09
EP98810095 1998-02-09
PCT/IB1999/000182 WO1999039738A1 (en) 1998-02-09 1999-02-02 Targeted delivery of biologically active media

Publications (2)

Publication Number Publication Date
DE69925461D1 true DE69925461D1 (de) 2005-06-30
DE69925461T2 DE69925461T2 (de) 2006-04-27

Family

ID=8235927

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925461T Expired - Lifetime DE69925461T2 (de) 1998-02-09 1999-02-02 Zielgerichtete abgabe von biologische-aktive medien

Country Status (11)

Country Link
US (1) US6258378B1 (de)
EP (1) EP1056473B8 (de)
JP (1) JP4772958B2 (de)
AT (1) ATE296113T1 (de)
AU (1) AU753196B2 (de)
CA (1) CA2319433C (de)
DE (1) DE69925461T2 (de)
ES (1) ES2244169T3 (de)
NZ (1) NZ506051A (de)
WO (1) WO1999039738A1 (de)
ZA (1) ZA99987B (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19913699A1 (de) 1999-03-26 2000-09-28 Basf Ag Verfahren zur Herstellung von 3,4-Dihydroprolinen und 3,4-Dehydropiperidinen
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
US7230088B2 (en) 2001-07-03 2007-06-12 Mallinckrodt, Inc. Compounds for dual photodiagnosis and therapy
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US7282215B2 (en) * 2000-05-08 2007-10-16 The University Of British Columbia Supports for photosensitizer formulations
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
AU2002245629A1 (en) * 2001-03-08 2002-09-24 Targesome, Inc. Stabilized therapeutic and imaging agents
GB0118517D0 (en) * 2001-07-30 2001-09-19 Mitsubishi Tokyo Pharm Inc Compound
JP2005504756A (ja) * 2001-08-08 2005-02-17 マリア・アントニア・ガルシア−オルメド・ドミンゲス 注射可能な泡製剤および新規な医薬的適用
US20150037402A1 (en) * 2001-08-13 2015-02-05 Lipella Pharmaceuticals, Inc. Methods and Compositions for Treating Gastric Disorders
US20130071466A1 (en) * 2001-08-13 2013-03-21 Lipella Pharmaceuticals Inc. Methods and compositions for treating gastric disorders
IL160228A0 (en) * 2001-08-16 2004-07-25 Bristol Myers Squibb Pharma Co Gas microsphere-liposome composites gas microsphere-liposome composites
CA2481020A1 (en) * 2001-09-28 2003-04-03 Saoirse Corporation Localized non-invasive biological modulation system
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US7141044B2 (en) 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
JP3816809B2 (ja) * 2002-01-30 2006-08-30 株式会社日立製作所 薬剤、薬剤キャリア、薬剤の製造方法及び腫瘍の治療方法
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
AU2003213730A1 (en) 2002-03-01 2003-09-16 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
WO2004004635A2 (en) * 2002-07-02 2004-01-15 Board Of Regents, The University Of Texas System Radiolabeled compounds and liposomes and their methods of making and using the same
AU2003272341A1 (en) * 2002-09-11 2004-04-30 Duke University Methods and compositions for blood pool identification, drug distribution quantification and drug release verification
US7769423B2 (en) * 2002-09-11 2010-08-03 Duke University MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
DK1590006T3 (da) 2003-02-04 2010-12-20 Bracco Suisse Sa Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
JP2006514662A (ja) * 2003-02-12 2006-05-11 アンスティテュ、ナショナル、ド、ラ、サント、エ、ド、ラ、ルシェルシュ、メディカル（アンセルム） コロイド状キャリヤーの表面におけるｐ糖タンパク質インヒビター界面活性剤の使用
WO2004078778A2 (en) 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
US7338796B1 (en) * 2003-08-13 2008-03-04 Sandia Corporation Vesicle-based method and apparatus for collecting, manipulating, and chemically processing trace macromolecular species
WO2005041932A2 (en) * 2003-11-03 2005-05-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method for selecting cationic or anionic liposomes for treatment of a mucosa membrane, and kit comprising the same
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
JP2007515471A (ja) * 2003-12-22 2007-06-14 ブラッコ・リサーチ・ソシエテ・アノニム 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー
US7341569B2 (en) 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
CA2586130A1 (en) * 2004-11-22 2006-05-26 Oxygenix Co., Ltd. Reagent containing oxygen isotope-labeled hemoglobin for examining vital tissue and method of producing the same
US8664392B2 (en) 2004-12-23 2014-03-04 Medibeacon, LLC Pyrazine derivatives for bioconjugation
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
JP4911915B2 (ja) * 2005-05-09 2012-04-04 トヨタ自動車株式会社 標的物の分解方法及び分解装置
AU2005332157A1 (en) * 2005-05-23 2006-11-30 Mebiopharm Co., Ltd., Method of producing liposomes containing gas enclosed therein
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US20070026024A1 (en) * 2005-07-27 2007-02-01 Drees Thomas C Compositions and methods for emulsifying a pefluorocarbon with an oxygen-carrying surfactant
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
DE102005063375A1 (de) * 2005-09-15 2007-04-19 Schülke & Mayr GmbH Antimikrobielle Zubereitungen mit einem Gehalt an Octenidindihydrochlorid verkapselt in Liposomen
US8257338B2 (en) * 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US20080200863A1 (en) * 2005-12-02 2008-08-21 Cabochon Aesthetics, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US20070184085A1 (en) * 2006-02-03 2007-08-09 Boston Scientific Scimed, Inc. Ultrasound activated medical device
EP2001893A2 (de) * 2006-03-02 2008-12-17 Mallinckrodt, Inc. Thiadiazolverbindungen und ihre verwendung in der lichttherapie
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
JP2009529533A (ja) * 2006-03-10 2009-08-20 マリンクロット インコーポレイテッド 光活性の化合物および組成物、ならびにそれらの使用方法
WO2007127176A2 (en) 2006-04-24 2007-11-08 Ekos Corporation Ultrasound therapy system
US20080089928A1 (en) * 2006-06-13 2008-04-17 Stavroula Sofou Liposome drug carriers with ph-sensitivity
JP2009534396A (ja) 2006-06-22 2009-09-24 マリンクロッド・インコーポレイテッド ピラジン誘導体および腎臓の監視におけるその使用
DE602007006968D1 (de) 2006-09-05 2010-07-15 Bracco Research Sa Gasgefüllte mikrovesikel mit polymer-modifizierten lipiden
US9456983B1 (en) 2006-12-08 2016-10-04 Advanced Cardiovascular Systems, Inc. Therapeutic composition with enhanced vessel targeting
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US9493817B2 (en) * 2007-03-05 2016-11-15 Genesis Research Institute, Inc. Decomposition method and decomposition apparatus for nucleic acid polymer
US8372427B2 (en) 2007-03-05 2013-02-12 Abbott Cardiovascular Systems Inc. Therapeutic composition with enhanced endothelium targeting
US9044385B2 (en) * 2007-05-16 2015-06-02 Abbott Cardiovascular Systems Inc. Therapeutic compositions for targeted vessel delivery
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US20090047318A1 (en) 2007-08-16 2009-02-19 Abbott Cardiovascular Systems Inc. Nanoparticle-coated medical devices and formulations for treating vascular disease
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US8709472B1 (en) 2007-11-13 2014-04-29 Abbott Cardiovascular Systems Inc. Bioactive agent-loaded heart-targeting nanoparticles
WO2009075582A2 (en) * 2007-12-10 2009-06-18 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids
WO2009083972A2 (en) * 2008-01-03 2009-07-09 Do-Coop Technologies Ltd. Compositions and methods for enhancing the activity of podophyllotoxin
EP2350205A2 (de) * 2008-09-29 2011-08-03 Mallinckrodt Inc. Dithienofuranfarbstoffe für bildgebung und therapie
US20110196231A1 (en) * 2008-09-29 2011-08-11 Raghavan Rajagopalan Fused Ring Thiophene Dyes for Imaging and Therapy
CA2738035A1 (en) * 2008-09-29 2010-04-01 Mallinckrodt Inc. Dithienopyrrole dyes for imaging and therapy
AU2009301141B2 (en) 2008-10-07 2015-08-27 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
EP2376459B1 (de) 2008-12-17 2015-02-18 MediBeacon, LLC Modifizierte pyrazinderivate und anwendungen davon
WO2010121003A1 (en) 2009-04-16 2010-10-21 Mallinckrodt Inc. Pyrazine derivatives for optical imaging and therapy
JP5491067B2 (ja) * 2009-05-08 2014-05-14 一雄 丸山 リポソーム、リポソームの製造方法、及び医薬組成物
WO2010132554A2 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
WO2010132515A1 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Compounds containing acyclic n-n bonds for phototherapy
EP2253308A1 (de) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmazeutische Zusammensetzung mit Mikrobläschen zur gezielten Tumorbehandlung
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
WO2011031955A2 (en) 2009-09-11 2011-03-17 Mallinckrodt Inc. Optical monitoring of leukemia
EP2305216A1 (de) * 2009-09-25 2011-04-06 Koninklijke Philips Electronics N.V. Zweistufen-Ultraschallprotokoll zur Arzneimittelabgabe
WO2011060113A1 (en) 2009-11-11 2011-05-19 Mallinckrodt Inc. Sulfenamide compounds for phototherapy
US10010709B2 (en) 2009-12-16 2018-07-03 The Trustees Of Columbia University In The City Of New York Composition for on-demand ultrasound-triggered drug delivery
WO2011084571A2 (en) 2009-12-16 2011-07-14 Mallinckrodt Inc. Azide derivatives for phototherapy
EP2363136A1 (de) 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Von Erwachsenenstammzellen abgeleitete Mikrovesikel zur Verwendung bei der therapeutischen Behandlung von Tumorkrankheiten
WO2012119781A2 (en) 2011-03-10 2012-09-13 University Of Geneva Novel lipids, phospholipids, phospholipid and lipid compositions and their use
WO2013039851A1 (en) 2011-09-12 2013-03-21 Mallinckrodt Llc Optical agents for imaging and visualization of matrix metalloproteinase enzymes
JP2012246306A (ja) * 2012-08-22 2012-12-13 Btg Internatl Ltd 注射可能な泡製剤および新規な医薬的適用
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
AU2014296454B2 (en) 2013-07-29 2018-06-21 Attillaps Holdings Organophosphates for treating afflictions of the skin
US11446241B2 (en) 2013-07-29 2022-09-20 Attillaps Holdings Inc. Treatment of ophthalmological conditions with acetylcholinesterase inhibitors
JP6876436B2 (ja) * 2013-09-27 2021-05-26 イグザクト・セラピューティクス・アーエス 超音波により媒介される薬物送達
US10639278B2 (en) 2013-10-22 2020-05-05 Lipella Pharmaceuticals, Inc. Delivery of agents using metastable liposomes
KR20150062652A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법
DK3157534T3 (da) 2014-06-19 2022-08-22 Attillaps Holdings Acetylcholinesterasehæmmere til behandling af dermatologiske tilstande
EA201791437A1 (ru) 2014-12-31 2017-12-29 Лантеус Медикал Имэджинг, Инк. Композиции микросфер c инкапсулированным в липиде газом и соответствующие способы
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
MX2018005063A (es) 2015-11-02 2018-12-10 Bioatla Llc Polipéptidos condicionalmente activos.
JP2019515936A (ja) 2016-05-04 2019-06-13 ランセウス メディカル イメージング， インコーポレイテッド 超音波造影剤を調製するための方法およびデバイス
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10849924B2 (en) 2017-09-26 2020-12-01 New York Medical College Compositions and methods for restoring endothelial glycocalyx
WO2019118458A1 (en) * 2017-12-11 2019-06-20 Respirogen, Inc. Devices and methods for delivery of oxygen to a wound
JP2023543527A (ja) 2020-09-16 2023-10-16 アビセーダ セラピューティクス，インコーポレイテッド シアル酸リガンド修飾治療薬
WO2023129737A1 (en) 2021-12-31 2023-07-06 Aviceda Therapeutics, Inc. Glycomimetic ligands
CN115025219B (zh) * 2022-06-10 2023-07-04 上海工程技术大学 一种超声响应尿激酶溶栓纳米脂质体及其制备与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5773024A (en) 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
DE59409568D1 (de) * 1993-09-09 2000-11-30 Schering Ag Wirkstoffe und gas enthaltende mikropartikel
GB9318841D0 (en) * 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition

Also Published As

Publication number Publication date
WO1999039738A1 (en) 1999-08-12
US6258378B1 (en) 2001-07-10
AU1980999A (en) 1999-08-23
EP1056473B8 (de) 2005-07-20
EP1056473B1 (de) 2005-05-25
ES2244169T3 (es) 2005-12-01
ZA99987B (en) 1999-08-06
JP4772958B2 (ja) 2011-09-14
CA2319433C (en) 2008-04-22
JP2002502829A (ja) 2002-01-29
ATE296113T1 (de) 2005-06-15
CA2319433A1 (en) 1999-08-12
NZ506051A (en) 2003-08-29
EP1056473A1 (de) 2000-12-06
DE69925461T2 (de) 2006-04-27
AU753196B2 (en) 2002-10-10

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