DE69926260D1 - Kompositmatrix mit mikrokugeln - Google Patents

Kompositmatrix mit mikrokugeln

Info

Publication number
DE69926260D1
DE69926260D1 DE69926260T DE69926260T DE69926260D1 DE 69926260 D1 DE69926260 D1 DE 69926260D1 DE 69926260 T DE69926260 T DE 69926260T DE 69926260 T DE69926260 T DE 69926260T DE 69926260 D1 DE69926260 D1 DE 69926260D1
Authority
DE
Germany
Prior art keywords
microballs
composite matrix
composite
arrays
samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69926260T
Other languages
English (en)
Other versions
DE69926260T3 (de
DE69926260T2 (de
Inventor
S Chee
R Auger
R Stuelpnagel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Illumina Inc
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26811698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69926260(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of DE69926260D1 publication Critical patent/DE69926260D1/de
Application granted granted Critical
Publication of DE69926260T2 publication Critical patent/DE69926260T2/de
Publication of DE69926260T3 publication Critical patent/DE69926260T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00382Stamping
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
DE69926260.7T 1998-12-28 1999-12-28 Kompositmatrix mit mikrokugeln Expired - Lifetime DE69926260T3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11396898P 1998-12-28 1998-12-28
US113968P 1998-12-28
US09/256,943 US6429027B1 (en) 1998-12-28 1999-02-24 Composite arrays utilizing microspheres
US256943 1999-02-24
EP99967670.3A EP1141712B2 (de) 1998-12-28 1999-12-28 Kompositmatrix mit mikrokugeln
PCT/US1999/031022 WO2000039587A1 (en) 1998-12-28 1999-12-28 Composite arrays utilizing microspheres

Publications (3)

Publication Number Publication Date
DE69926260D1 true DE69926260D1 (de) 2005-08-25
DE69926260T2 DE69926260T2 (de) 2006-04-27
DE69926260T3 DE69926260T3 (de) 2016-05-19

Family

ID=26811698

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69941068T Expired - Lifetime DE69941068D1 (de) 1998-12-28 1999-12-28 Kompositmatrix
DE69926260.7T Expired - Lifetime DE69926260T3 (de) 1998-12-28 1999-12-28 Kompositmatrix mit mikrokugeln
DE29925020U Expired - Lifetime DE29925020U1 (de) 1998-12-28 1999-12-28 Zusammengesetzte Arrays mit Mikrokügelchen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69941068T Expired - Lifetime DE69941068D1 (de) 1998-12-28 1999-12-28 Kompositmatrix

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE29925020U Expired - Lifetime DE29925020U1 (de) 1998-12-28 1999-12-28 Zusammengesetzte Arrays mit Mikrokügelchen

Country Status (8)

Country Link
US (3) US6429027B1 (de)
EP (3) EP1593967B1 (de)
JP (2) JP3566653B2 (de)
AT (2) ATE435423T1 (de)
AU (1) AU775056B2 (de)
CA (2) CA2729739C (de)
DE (3) DE69941068D1 (de)
WO (1) WO2000039587A1 (de)

Families Citing this family (385)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
CN1181720A (zh) * 1995-04-25 1998-05-13 伊萝莉公司 可远程编程的存储器材料及其应用
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
ES2288760T3 (es) * 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6327410B1 (en) * 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
EP0985142A4 (de) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US8236500B2 (en) 1997-10-23 2012-08-07 The United States Of America, As Represented By The Department Of Veterans Affairs Promoter variants of the alpha-7 nicotinic acetylcholine receptor
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
EP1090293B2 (de) * 1998-06-24 2019-01-23 Illumina, Inc. Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ, エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US7595189B2 (en) 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
EP1923472B1 (de) 1999-04-20 2012-04-11 Illumina, Inc. Erkennung von Nukleinsäurereaktionen auf Bead-Arrays
EP1190100B1 (de) 1999-05-20 2012-07-25 Illumina, Inc. Kombinatorische entschlüsselung von zufallsnukleinsäurearrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
DK1218545T3 (da) 1999-08-18 2012-02-20 Illumina Inc Fremgangsmåder til fremstilling af oligonukleotidopløsninger
US6642046B1 (en) * 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
EP1240498B1 (de) * 1999-12-23 2008-12-17 Illumina, Inc. Dekodierung von matrixsensoren mit mikrokugeln
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
CN1430726A (zh) * 2000-03-21 2003-07-16 伊利诺伊大学受托管理委员会 具有染料阵列的比色人工鼻和用于人工嗅觉的方法
US6759235B2 (en) * 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
US7338773B2 (en) * 2000-04-14 2008-03-04 Millipore Corporation Multiplexed assays of cell migration
WO2003036265A2 (en) * 2001-10-26 2003-05-01 Virtual Arrays, Inc. Assay systems with adjustable fluid communication
US6921637B2 (en) * 2000-05-04 2005-07-26 The Cbr Institute For Biomedical Research, Inc. Colloid compositions for solid phase biomolecular analytical, preparative and identification systems
DE10065632A1 (de) * 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren zum Nachweis von Polynukleotiden
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (es) * 2000-06-21 2006-10-16 Bioarray Solutions Ltd Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
AU7166201A (en) * 2000-06-28 2002-01-08 Illumina Inc Composite arrays utilizing microspheres with a hybridization chamber
ATE399216T1 (de) 2000-07-11 2008-07-15 Kirk Hogan Verfahren und zusammensetzungen zur perioperativen genomischen profilerstellung
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US20050090021A1 (en) * 2000-10-06 2005-04-28 Walt David R. Self-encoding sensor with microspheres
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US7060442B2 (en) 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
WO2002040634A2 (en) * 2000-11-14 2002-05-23 Genetag Technology, Inc. Expression miniarrays and uses thereof
EP2202520A1 (de) * 2000-11-27 2010-06-30 Intelligent Medical Devices LLC Klinische intelligente diagnostische Vorrichtungen und Verfahren
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
JP3525142B2 (ja) * 2001-01-12 2004-05-10 独立行政法人 科学技術振興機構 金属ナノウェルを用いた蛍光分析用素子及びその製造方法
WO2002057743A2 (en) * 2001-01-17 2002-07-25 Streamline Proteomics, Llc. Methods of analyzing and sorting one or more analytes
US7041449B2 (en) * 2001-03-19 2006-05-09 Wisconsin Alumni Research Foundation Methods of screening for compounds that inhibit expression of biomarker sequences differentially expressed with age in mice
CN1500140A (zh) * 2001-03-28 2004-05-26 上海晶泰生物技术有限公司 用于测试多种待分析物的装置及方法
WO2002084283A2 (en) * 2001-04-10 2002-10-24 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Method for determining analyte molecules in a sample
DE10119468A1 (de) * 2001-04-12 2002-10-24 Epigenomics Ag Mikroarray-Verfahren zur Anreicherung von DNA-Fragmenten aus komplexen Mischungen
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
NL1017989C2 (nl) * 2001-05-03 2002-11-05 Univ Delft Tech Werkwijze voor het uitvoeren van een assay, inrichting daarvoor, alsmede een werkwijze voor het vervaardigen van een inrichting.
GB0113358D0 (en) * 2001-06-01 2001-07-25 Scient Generics Ltd Enhanced target capture
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
JP2005528582A (ja) * 2001-09-07 2005-09-22 コーニング インコーポレイテッド ハイスループット分析のためのマイクロカラム・プラットフォームに基づくアレイ
US7195913B2 (en) * 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
WO2003030879A1 (en) 2001-10-05 2003-04-17 Surmodics, Inc. Particle immobilized coatings and uses thereof
EP2722395B1 (de) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
US7381375B2 (en) * 2001-10-26 2008-06-03 Millipore Corporation Assay systems with adjustable fluid communication
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
JP2005509883A (ja) * 2001-11-15 2005-04-14 アリックス,インコーポレーテッド 試料チップ
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7255986B2 (en) 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
US8765484B2 (en) * 2002-02-07 2014-07-01 The Regents Of The University Of California Optically encoded particles
AU2003220254B2 (en) 2002-03-13 2008-09-18 Syngenta Participations, Ag. Nucleic acid detection method
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US6730515B2 (en) * 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
US20040096622A1 (en) * 2002-06-19 2004-05-20 Ali Razavi Multi well plate with self sealing advantages
ATE470722T1 (de) * 2002-07-19 2010-06-15 Althea Technologies Inc Strategien zur genexpressionsanalyse
US7462448B2 (en) 2002-08-02 2008-12-09 Stratatech Corporation Species specific DNA detection
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
AU2003260116A1 (en) * 2002-08-28 2004-03-19 Mabgen L.L.C. Selecting therapeutic human monoclonal antibodies from disease-specific libraries
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
JP4087200B2 (ja) * 2002-09-17 2008-05-21 ユニバーサル・バイオ・リサーチ株式会社 粒子複合体及び該粒子複合体の作製方法
US7364846B2 (en) * 2002-10-11 2008-04-29 Molecular Devices Corporation Gene expression profiling from FFPE samples
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
JP2004184312A (ja) * 2002-12-05 2004-07-02 Yokogawa Electric Corp 生体高分子検出方法およびバイオチップ
ATE525469T1 (de) 2002-12-18 2011-10-15 Third Wave Tech Inc Nachweis kleiner nukleinsäuren
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
TWI220766B (en) * 2003-04-17 2004-09-01 Au Optronics Corp Method for fabricating liquid crystal display panel array
US8150626B2 (en) * 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US8150627B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7670810B2 (en) 2003-06-20 2010-03-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050019954A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Photochromic dyes for microsphere based sensor
US20050019944A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Colorable microspheres for DNA and protein microarray
US8022013B2 (en) * 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
JP2005077284A (ja) * 2003-09-01 2005-03-24 Seiko Epson Corp 粒子アレイの製造装置及び製造方法と標的物質の検出方法
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US7259258B2 (en) 2003-12-17 2007-08-21 Illumina, Inc. Methods of attaching biological compounds to solid supports using triazine
US8308066B2 (en) * 2003-12-22 2012-11-13 The Regents Of The University Of California Method for forming optically encoded thin films and particles with grey scale spectra
AU2004308380A1 (en) * 2003-12-22 2005-07-14 The Regents Of The University Of California Optically encoded particles, system and high-throughput screening
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
US7432057B2 (en) 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
DE102004021351A1 (de) * 2004-04-23 2005-11-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Funktionalisierter poröser Träger für Mikroarrays
US7462451B2 (en) 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
EP2527447A1 (de) 2004-06-03 2012-11-28 Athlomics Pty Ltd Mittel und Verfahren zur Diagnose von Stress
CA2565967A1 (en) * 2004-06-10 2005-12-29 Perkinelmer Las, Inc. Multiplexing assays for analyte detection
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
US7440930B1 (en) * 2004-07-22 2008-10-21 Adobe Systems Incorporated Training an attentional cascade
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
WO2006062745A2 (en) * 2004-11-23 2006-06-15 454 Life Sciences Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7647186B2 (en) * 2004-12-07 2010-01-12 Illumina, Inc. Oligonucleotide ordering system
US20060131361A1 (en) * 2004-12-16 2006-06-22 Eastman Paul S Quantum dot-encoded bead set for calibration and quantification of multiplexed assays, and methods for their use
US7634142B1 (en) 2005-01-24 2009-12-15 Adobe Systems Incorporated Detecting objects in images using a soft cascade
EP1844162B1 (de) 2005-02-01 2014-10-15 Applied Biosystems, LLC vERFAHREN ZUR SEQUENZBESTIMMUNG IN EINEM POLYNUKLEOTID
EP2233582A1 (de) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
US9040237B2 (en) * 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US9695472B2 (en) 2005-03-04 2017-07-04 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US20070108465A1 (en) * 2005-03-10 2007-05-17 The Regents Of The University Of California Porous microstructure multi layer spectroscopy and biosensing
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
EP1715344A1 (de) * 2005-04-22 2006-10-25 Universiteit Utrecht Holding B.V. Immobilisierung der Antigenkohlenhydrate, zum der pathogenen Mikroorganismen zu ermitteln
WO2006124664A2 (en) 2005-05-12 2006-11-23 Third Wave Technologies, Inc. Polymorphic ghsr nucleic acids and uses thereof
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
EP1910565A4 (de) 2005-07-07 2009-10-28 Athlomics Pty Ltd Polynukleotidmarkergene und deren expression zur diagnose von endotoxämie
US7595473B2 (en) * 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
WO2007044711A1 (en) 2005-10-07 2007-04-19 University Of Florida Research Foundation, Inc. Multiple component nanoparticles for multiplexed signaling and optical encoding
US7803751B2 (en) * 2005-12-09 2010-09-28 Illumina, Inc. Compositions and methods for detecting phosphomonoester
CA2640385C (en) 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) * 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
AU2007237909A1 (en) * 2006-04-19 2007-10-25 Applied Biosystems, Llc. Reagents, methods, and libraries for gel-free bead-based sequencing
US8933209B2 (en) 2006-04-26 2015-01-13 Abbvie Inc. Dep2 and its uses in major depressive disorder and other related disorders
KR100772897B1 (ko) * 2006-05-02 2007-11-05 삼성전자주식회사 향상된 잡음률을 나타내는 올리고머 프로브 어레이 및 그제조 방법
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP5260503B2 (ja) 2006-06-01 2013-08-14 サード ウェーブ テクノロジーズ,インコーポレーテッド 核酸の検出
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2024512A4 (de) 2006-06-14 2009-12-09 Artemis Health Inc Verfahren zur diagnose fötaler anomalitäten
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP4108780A1 (de) 2006-06-14 2022-12-28 Verinata Health, Inc. Analyse seltener zellen mittels probentrennung und dna-etiketten
AU2007321678B2 (en) 2006-11-15 2014-03-20 The University Of British Columbia Polymorphisms predictive of anthracycline-induced cardiotoxicity
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
CA2672315A1 (en) 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US8930178B2 (en) 2007-01-04 2015-01-06 Children's Hospital Medical Center Processing text with domain-specific spreading activation methods
JP2010520745A (ja) 2007-02-07 2010-06-17 デコード・ジェネティクス・イーエイチエフ 前立腺癌のリスクに寄与する遺伝子変異体
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
MX2009012722A (es) 2007-05-25 2009-12-11 Decode Genetics Ehf Variantes geneticas sobre chr 5p12 y 10q26 como marcadores para el uso en la evaluacion del riesgo, diagnostico, pronostico y tratamiento del cancer de mama.
CN101320404B (zh) * 2007-06-06 2010-05-26 中国科学院半导体研究所 一种生物病毒的计算机自动分类方法
WO2009012340A2 (en) 2007-07-16 2009-01-22 California Institute Of Technology Microfluidic devices, methods and systems for detecting target molecules
ES2556627T3 (es) * 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US8877141B2 (en) * 2007-09-06 2014-11-04 Qiagen Sciences Llc System for preparing arrays of biomolecules
FR2921002B1 (fr) * 2007-09-13 2010-11-12 Innopsys Procede de depot simultane d'un ensemble de motifs sur un substrat par un macro timbre
EP2212434A1 (de) * 2007-10-01 2010-08-04 Applied Biosystems Inc. Chase-ligation-sequenzierung
CA2702169A1 (en) * 2007-10-12 2009-04-16 Decode Genetics Ehf Sequence variants for inferring human pigmentation patterns
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US8697360B2 (en) 2007-11-30 2014-04-15 Decode Genetics Ehf. Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
US8202691B2 (en) 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
CA2714521A1 (en) * 2008-02-14 2009-08-20 Decode Genetics Ehf Susceptibility variants for lung cancer
EP2252896B1 (de) * 2008-03-12 2014-07-02 Universite De Rouen Verfahren zur hochempfindlichen detektion und quantifizierung von biomolekülen mittels sekundärionenmassenspektrometrie (sims)
US20090253142A1 (en) 2008-03-15 2009-10-08 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
CA2724666A1 (en) 2008-04-01 2009-10-08 Decode Genetics Ehf Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm
WO2009137521A2 (en) * 2008-05-07 2009-11-12 Illumina, Inc. Compositions and methods for providing substances to and from an array
US8470164B2 (en) 2008-06-25 2013-06-25 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2010001419A2 (en) * 2008-07-04 2010-01-07 Decode Genetics Ehf Copy number variations predictive of risk of schizophrenia
US20110168975A1 (en) * 2008-07-07 2011-07-14 Bruce Cohen Caged quantum dots
CA2729934A1 (en) 2008-07-07 2010-01-14 Decode Genetics Ehf Genetic variants for breast cancer risk assessment
CN102177252B (zh) * 2008-08-12 2014-12-24 解码遗传学私营有限责任公司 用于甲状腺癌症的风险评估的遗传变型
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
US20110212855A1 (en) * 2008-08-15 2011-09-01 Decode Genetics Ehf. Genetic Variants Predictive of Cancer Risk
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
ES2728379T3 (es) * 2008-11-19 2019-10-24 Euroimmun Medizinische Labordiagnostika Ag Procedimientos de análisis y dispositivos para reacciones biológicas entre una fase líquida y una fase sólida
EP2373817A4 (de) * 2008-12-10 2013-01-02 Illumina Inc Verfahren und zusammensetzungen zur hybridisierung von nukleinsäuren
CN104404134B (zh) * 2009-04-03 2017-05-10 莱弗斯基因股份有限公司 多重核酸检测方法和系统
CN102449165B (zh) 2009-04-03 2014-07-09 解码遗传学私营有限责任公司 用于心房颤动和中风的风险管理的遗传标志
NZ596070A (en) * 2009-05-08 2013-10-25 Decode Genetics Ehf Genetic variants contributing to risk of prostate cancer
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
EP2451977A4 (de) 2009-07-10 2013-01-02 Decode Genetics Ehf Genetische marker für das risiko von diabetes mellitus
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
CN102665753A (zh) 2009-07-31 2012-09-12 佛多斯大学医学研究中心 诊断或预测hcv感染的患者中丙型肝炎后果的方法
WO2011047087A2 (en) 2009-10-13 2011-04-21 Nanostring Technologies, Inc. Protein detection via nanoreporters
CA2684636A1 (en) * 2009-10-30 2011-04-30 Sqi Diagnostics Systems Inc Multiplex microarrays and methods for the quantification of analytes
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
CA2779750C (en) 2009-11-06 2019-03-19 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
US8500979B2 (en) * 2009-12-31 2013-08-06 Intel Corporation Nanogap chemical and biochemical sensors
EP2525905B1 (de) 2010-01-19 2020-11-04 Illumina, Inc. Verfahren und zusammensetzungen zur verarbeitung chemischer reaktionen
JP5914362B2 (ja) 2010-02-11 2016-05-11 ナノストリング テクノロジーズ, インコーポレイテッド 低分子rna分子の検出のための組成物および方法
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
ES2544635T3 (es) 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
JP5952813B2 (ja) 2010-06-30 2016-07-13 ライフ テクノロジーズ コーポレーション Isfetアレイをテストする方法及び装置
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
EP2589065B1 (de) 2010-07-03 2015-08-19 Life Technologies Corporation Chemisch empfindlicher sensor mit leicht dotierten abflüssen
WO2012018387A2 (en) 2010-08-02 2012-02-09 Population Diagnotics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
US8715932B2 (en) 2010-08-20 2014-05-06 Intel Corporation Nucleic acid sequencing
US8444835B2 (en) 2010-09-09 2013-05-21 Intel Corporation Electronic and fluidic interface
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2619564B1 (de) 2010-09-24 2016-03-16 Life Technologies Corporation Transistorschaltungen mit zusammengehörigen paaren
AU2011305445B2 (en) 2010-09-24 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
US8759038B2 (en) 2010-09-29 2014-06-24 Illumina Cambridge Limited Compositions and methods for sequencing nucleic acids
EP2633069B1 (de) 2010-10-26 2015-07-01 Illumina, Inc. Sequenzierungsverfahren
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
WO2012095872A1 (en) 2011-01-13 2012-07-19 Decode Genetics Ehf Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment
FR2970568B1 (fr) * 2011-01-14 2016-05-06 Centre Nat Rech Scient Nouvelles surfaces adhesives pour l'immobilisation de ligands
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012106081A2 (en) 2011-01-31 2012-08-09 Illumina, Inc. Methods for reducing nucleic acid damage
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
WO2012139110A2 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
EP2699903B1 (de) 2011-04-20 2018-07-18 Life Technologies Corporation Verfahren, zusammensetzungen und systeme zur probenablagerung
US20140154209A1 (en) 2011-06-30 2014-06-05 Centre Hospitalier Universitaire Vaudois Polymorphisms associated with non-response to a hepatitis c treatment or susceptibility to non-spontaneous hepatitis c clearance
WO2013030786A1 (en) 2011-08-31 2013-03-07 Centre Hospitalier Universitaire Vaudois Method for diagnosing or predicting hepatocellular carcinoma outcome
US9435812B2 (en) 2011-08-31 2016-09-06 Ventana Medical Systems, Inc. Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
WO2013043922A1 (en) 2011-09-22 2013-03-28 ImmuMetrix, LLC Compositions and methods for analyzing heterogeneous samples
US20140271542A1 (en) 2011-10-05 2014-09-18 The United States Of America As Represented By The Secretary, Department Of Health And Human Service Genetic marker for predicting prognosis in patients infected with hepatitis c virus
CA2851388C (en) 2011-10-10 2023-11-21 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
US11180807B2 (en) 2011-11-04 2021-11-23 Population Bio, Inc. Methods for detecting a genetic variation in attractin-like 1 (ATRNL1) gene in subject with Parkinson's disease
WO2013082308A1 (en) 2011-11-30 2013-06-06 Children's Hospital Medical Center Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
WO2013096661A1 (en) 2011-12-22 2013-06-27 Illumina, Inc. Methylation biomarkers for ovarian cancer
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
NO2694769T3 (de) 2012-03-06 2018-03-03
EP2836482B1 (de) 2012-04-10 2019-12-25 The Regents of The University of California Zusammensetzungen und verfahren zur behandlung von krebs
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
CN104884605B (zh) * 2012-08-24 2018-05-18 耶鲁大学 用于高通量多重检测的系统、装置和方法
DK2895621T3 (da) 2012-09-14 2020-11-30 Population Bio Inc Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
CA2922005A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
CN105283758B (zh) 2013-03-15 2018-06-05 生命科技公司 具有一致传感器表面区域的化学传感器
DK3327123T3 (da) 2013-03-15 2019-11-25 Lineage Biosciences Inc Fremgangsmåder til sekvensering af immunrepertoiret
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
CN105051525B (zh) 2013-03-15 2019-07-26 生命科技公司 具有薄导电元件的化学设备
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US9778187B2 (en) 2013-06-06 2017-10-03 Koninklijke Philips N.V. Correction for osmotic pressure variations in chemo-optical sensor spots
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
CN106132555B (zh) 2013-11-11 2019-07-26 生命科技股份有限公司 转子组合件及其使用方法
EP2891722B1 (de) 2013-11-12 2018-10-10 Population Bio, Inc. Verfahren und Zusammensetzungen zur Diagnose, Prognose und Behandlung von Endometriose
EP3110968B1 (de) 2014-02-24 2019-04-17 Children's Hospital Medical Center Verfahren und zusammensetzungen zur personalisierten schmerzbekämpfung
EP3177738B1 (de) 2014-08-08 2019-10-09 Children's Hospital Medical Center Diagnoseverfahren zur unterscheidung von formen von ösophagealer eosinophilie
GB2558326B (en) 2014-09-05 2021-01-20 Population Bio Inc Methods and compositions for inhibiting and treating neurological conditions
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049524A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
GB2546441B (en) * 2014-11-27 2020-07-29 Hitachi High Tech Corp Spot array substrate, method for producing same, and nucleic acid polymer analysis method and device
JP6767978B2 (ja) 2014-12-03 2020-10-14 アイソプレキシス コーポレイション 細胞分泌プロファイルの分析およびスクリーニング
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
EP3234575B1 (de) 2014-12-18 2023-01-25 Life Technologies Corporation Vorrichtung zur messung von analyten unter verwendung von grossflächigen fet-arrays
EP3042722B1 (de) * 2015-01-07 2019-11-27 Personal Genomics Inc. Ausgerichtete ladesysteme und verfahren zum ausrichten eines geladenen partikels in einem well
US10363288B2 (en) 2015-01-14 2019-07-30 National Jewish Health Insulin mimotopes and methods of using the same
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
CA2976946C (en) * 2015-02-24 2023-09-19 City Of Hope Chemically encoded spatially addressed library screening platforms
BR112017021869A2 (pt) 2015-04-10 2018-12-11 Araxes Pharma Llc compostos quinazolina substituídos e métodos de uso dos mesmos
MX2017013275A (es) 2015-04-15 2018-01-26 Araxes Pharma Llc Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos.
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
EP3325650B1 (de) 2015-07-17 2024-01-03 Nanostring Technologies, Inc. Simultane quantifizierung der genexpression in einer benutzerdefinierten region eines gewebequerschnitts
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
EP3335042A4 (de) 2015-08-10 2019-04-17 Essenlix Corporation Bio-/chemische testvorrichtungen und -verfahren für vereinfachte schritte, kleine proben, beschleunigte geschwindigkeit und benutzerfreundlichkeit
MX2018003148A (es) 2015-09-14 2019-02-20 Essenlix Corp Dispositivo y sistema para analizar una muestra, particularmente sangre, asi como metodos de uso de los mismos.
JP6594528B2 (ja) 2015-09-14 2019-10-23 エッセンリックス コーポレーション 蒸気凝縮液、特に呼気凝縮液を採取し分析する装置及びシステム、並びにそれらの使用方法
EP3356354A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
WO2017058728A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058792A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10689356B2 (en) 2015-09-28 2020-06-23 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
EP3356349A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
US10647703B2 (en) 2015-09-28 2020-05-12 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
JP2018533939A (ja) 2015-10-19 2018-11-22 アラクセス ファーマ エルエルシー Rasの阻害剤をスクリーニングするための方法
KR20180081596A (ko) 2015-11-16 2018-07-16 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
WO2017106481A1 (en) 2015-12-17 2017-06-22 Illumina, Inc. Distinguishing methylation levels in complex biological samples
EP3402572B1 (de) 2016-01-13 2022-03-16 Children's Hospital Medical Center Zusammensetzungen und verfahren zur behandlung von allergischen entzündungserkrankungen
EP3432877B1 (de) 2016-03-24 2023-01-11 ImmunoMolecular Therapeutics, Inc. D-alpha-methyldopa zur behandlung von autoimmunerkrankungen
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
WO2018009547A1 (en) 2016-07-05 2018-01-11 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Diagnosing col6-related disorders and methods for treating same
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
CN110312711A (zh) 2016-10-07 2019-10-08 亚瑞克西斯制药公司 作为ras抑制剂的杂环化合物及其使用方法
EP4036578A1 (de) 2016-11-11 2022-08-03 Isoplexis Corporation Zusammensetzungen und verfahren zur gleichzeitigen genomischen, transkriptomischen und proteomischen analyse von einzelzellen
CN116334202A (zh) 2016-11-21 2023-06-27 纳米线科技公司 化学组合物及其使用方法
WO2018098372A1 (en) 2016-11-22 2018-05-31 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
WO2018112420A1 (en) 2016-12-15 2018-06-21 The Regents Of The University Of California Compositions and methods for treating cancer
EP3558121B1 (de) 2016-12-21 2022-06-08 Essenlix Corporation Vorrichtungen und verfahren zur authentifizierung einer probe und verwendung davon
US11618924B2 (en) 2017-01-20 2023-04-04 Children's Hospital Medical Center Methods and compositions relating to OPRM1 DNA methylation for personalized pain management
EP3573967A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Kondensierte bicyclische hetero-hetero-verbindungen und verfahren zur verwendung davon
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573954A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC Fusionierte bicyclische benzoheteroaromatische verbindungen und verfahren zur verwendung davon
EP3573971A1 (de) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-on-derivate und ähnliche verbindungen als kras-g12c-modulatoren zur behandlung von krebs
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
EP3579981A4 (de) 2017-02-07 2021-03-31 Essenlix Corporation Komprimierter open-flow-test und verwendung
CA3053002A1 (en) 2017-02-08 2018-08-16 Essenlix Corp. Bio/chemical material extraction and assay
JP7004732B2 (ja) 2017-02-09 2022-01-21 エッセンリックス コーポレーション 異なる間隔の高さを使用するアッセイ法
JP2020507770A (ja) 2017-02-09 2020-03-12 エッセンリックス コーポレーション 比色アッセイ法
US11940382B2 (en) 2017-02-09 2024-03-26 Essenlix Corporation Assay with amplification
CA3053301A1 (en) 2017-02-16 2018-08-23 Essenlix Corporation Assay with textured surface
US11639925B2 (en) * 2017-04-06 2023-05-02 Agilent Technologies, Inc. Method and apparatus for measuring physiological properties of biological samples
WO2018218070A2 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Covalent inhibitors of kras
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
CN110869357A (zh) 2017-05-25 2020-03-06 亚瑞克西斯制药公司 化合物及其用于治疗癌症的使用方法
US11280706B2 (en) 2017-08-01 2022-03-22 Essenlix Corporation Dilution calibration
US11243201B2 (en) 2017-08-01 2022-02-08 Essenlix Corporation Sample collection, holding and assaying
US11725227B2 (en) 2017-08-01 2023-08-15 Essenlix Corporation Devices and methods for examining drug effects on microorganisms
US11393561B2 (en) 2017-10-13 2022-07-19 Essenlix Corporation Devices and methods for authenticating a medical test and use of the same
US11609224B2 (en) 2017-10-26 2023-03-21 Essenlix Corporation Devices and methods for white blood cell analyses
US10807095B2 (en) 2017-10-26 2020-10-20 Essenlix Corporation Making and tracking assay card
US11237113B2 (en) 2017-10-26 2022-02-01 Essenlix Corporation Rapid pH measurement
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
WO2019118936A2 (en) 2017-12-14 2019-06-20 Essenlix Corporation Devices, systems, and methods for monitoring hair
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
US11052060B2 (en) 2018-02-12 2021-07-06 The Regents Of The University Of Colorado, A Body Corporate Compounds and methods for treating autoimmunity
SG11202007501SA (en) 2018-02-12 2020-09-29 Nanostring Technologies Inc Biomolecular probes and methods of detecting gene and protein expression
US11859250B1 (en) 2018-02-23 2024-01-02 Children's Hospital Medical Center Methods for treating eosinophilic esophagitis
US11013707B2 (en) 2018-03-23 2021-05-25 The Regents Of The University Of Colorado, A Body Corporate Administration of oral methyldopa
US11549139B2 (en) 2018-05-14 2023-01-10 Nanostring Technologies, Inc. Chemical compositions and methods of using same
BR112020022675A2 (pt) 2018-05-25 2021-02-17 Philip Morris Products S.A. método para classificar material vegetal
JP7437161B2 (ja) 2018-06-29 2024-02-22 イラミーナ インコーポレーテッド フローセル
US11885952B2 (en) 2018-07-30 2024-01-30 Essenlix Corporation Optics, device, and system for assaying and imaging
SI3625368T1 (sl) 2018-08-08 2023-04-28 Pml Screening, Llc Postopki z genetskim testiranjem za oceno tveganja za razvoj progresivne multifokalne levkoencefalopatije, ki jo povzroča virus John Cunningham
CN113167790A (zh) * 2018-10-24 2021-07-23 凸版印刷株式会社 免疫测定用杯及其制造方法、以及免疫测定方法
SG11202012748TA (en) 2018-12-14 2021-01-28 Illumina Cambridge Ltd Decreasing phasing with unlabeled nucleotides during sequencing
AU2019411267A1 (en) 2018-12-17 2021-01-07 Illumina Cambridge Limited Primer oligonucleotide for sequencing
WO2020126593A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
CN113008764B (zh) * 2020-06-17 2022-12-02 山东大学 一种单细胞功能评估试剂盒及评估方法
CA3198847A1 (en) 2020-10-19 2022-04-28 Bio-Rad Laboratories, Inc. System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
WO2024046838A1 (en) 2022-09-01 2024-03-07 Evonik Operations Gmbh Multi-species chip to detect dna-methylation
WO2024046839A1 (en) 2022-09-01 2024-03-07 Evonik Operations Gmbh Dna-methylation detection in animal-derived products
WO2024046840A1 (en) 2022-09-01 2024-03-07 Evonik Operations Gmbh Method of assessing protein production in cho cells

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200110A (en) 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
US4349510A (en) 1979-07-24 1982-09-14 Seppo Kolehmainen Method and apparatus for measurement of samples by luminescence
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4707454A (en) 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
US4499052A (en) 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4593728A (en) 1982-11-20 1986-06-10 Whitehead Thomas P Dispensing device and recording apparatus
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4682895A (en) 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4798738A (en) 1986-10-10 1989-01-17 Cardiovascular Devices, Inc. Micro sensor
US4824789B1 (en) 1986-10-10 1996-08-13 Minnesota Mining & Mfg Gas sensor
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
DE3681176D1 (de) 1986-12-01 1991-10-02 Molecular Biosystems Inc Verfahren zur erhoehung der empfindlichkeit von nukleinsaeure-hybridisierungstesten.
SE458968B (sv) 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US5132242A (en) 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US4785814A (en) 1987-08-11 1988-11-22 Cordis Corporation Optical probe for measuring pH and oxygen in blood and employing a composite membrane
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5575849A (en) 1988-11-25 1996-11-19 Canon Kabushiki Kaisha Apparatus for producing a substrate having a surface with a plurality of spherical dimples for photoconductive members
JPH02299598A (ja) 1989-04-14 1990-12-11 Ro Inst For Molecular Genetics & Geneteic Res 微視的サイズの別個の粒子と結合している核酸試料中のごく短い配列の全部または一部のオリゴヌクレチドプローブとのハイブリダイゼーションによる決定法
US5087820A (en) 1989-05-31 1992-02-11 Digital Diagnostic Corp. Radiometric analysis system for solid support samples
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5176881A (en) * 1989-08-11 1993-01-05 The University Of Tennessee Research Corporation Fiber optic-based regenerable biosensor
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0416148A1 (de) 1989-09-07 1991-03-13 RSM ANALYTISCHE INSTRUMENTE GmbH Einrichtung zum gleichzeitigen Messen von Mehrfachproben-Partikel-oder Quanten-Strahlungen
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
WO1991019813A1 (en) 1990-06-11 1991-12-26 The University Of Colorado Foundation, Inc. Nucleic acid ligands
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
EP0478319B1 (de) 1990-09-28 1997-04-02 Kabushiki Kaisha Toshiba Verfahren zum Gennachweis
US5105305A (en) 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5380489A (en) 1992-02-18 1995-01-10 Eastman Kodak Company Element and method for nucleic acid amplification and detection using adhered probes
AU2348092A (en) 1991-07-16 1993-02-23 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
WO1993008472A1 (en) 1991-10-15 1993-04-29 Multilyte Limited Binding assay employing labelled reagent
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5888723A (en) 1992-02-18 1999-03-30 Johnson & Johnson Clinical Diagnostics, Inc. Method for nucleic acid amplification and detection using adhered probes
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
EP0565999A2 (de) 1992-04-16 1993-10-20 Siemens Aktiengesellschaft Anordnung zur optischen Kopplung von zwei Gruppen von Wellenleitern
DE69313611T2 (de) 1992-07-02 1998-01-08 Erkki Soini Biospezifisches multiparameter-analyseverfahren
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3420765B2 (ja) 1992-09-14 2003-06-30 エス・アール・アイ・インターナシヨナル レーザー励起技術を用いる生物学的および他の分析のためのアップコンバート性レポータ
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
CA2102884A1 (en) 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
JP3302458B2 (ja) 1993-08-31 2002-07-15 富士通株式会社 集積化光装置及び製造方法
EP1157743B1 (de) 1993-10-28 2009-03-11 Houston Advanced Research Center Mikrofabriziertes poröses Durchflussgerät zur diskreten Bestimmung von Bindungsreaktionen
US5494798A (en) 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
US5496997A (en) 1994-01-03 1996-03-05 Pope; Edward J. A. Sensor incorporating an optical fiber and a solid porous inorganic microsphere
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
AU2990595A (en) 1994-07-26 1996-02-22 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6074614A (en) 1995-06-07 2000-06-13 Molecular Devices Corporation Multi-assay plate cover for elimination of meniscus
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5656241A (en) 1995-09-07 1997-08-12 Optical Sensors Incorporated Method for manufacturing fiber optic sensors
DE69638321D1 (de) 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
GB9521159D0 (en) 1995-10-16 1995-12-20 Brint Norman T A weapon
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
US5837196A (en) * 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
ATE207798T1 (de) 1996-03-15 2001-11-15 Harvard College Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
JP2002515044A (ja) 1996-08-21 2002-05-21 スミスクライン・ビーチャム・コーポレイション ビーズ−ベースのコンビナトリアルライブラリーを配列し合成する迅速方法
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
AU746737B2 (en) * 1996-11-06 2002-05-02 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
CA2276462C (en) * 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
EP1003904B1 (de) 1997-05-23 2007-07-11 BioArray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
EP0985142A4 (de) 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
EP1003910A1 (de) 1997-07-22 2000-05-31 Rapigene, Inc. Verschiedene funktionen eines arrayelementes und dessen anwendungen
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
AU4194899A (en) 1998-05-21 1999-12-06 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
WO1999067414A1 (en) 1998-06-24 1999-12-29 Glaxo Group Limited Nucleotide detection method
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
AU6131299A (en) 1998-08-26 2000-03-21 Trustees Of Tufts College Combinatorial polymer synthesis of sensors for polymer-based sensor arrays
ATE462970T1 (de) 1999-02-09 2010-04-15 Illumina Inc Screeningverfahren mit porösen mikrokügelchen und zusammensetzungen
WO2013139338A1 (en) 2012-03-20 2013-09-26 Martin Professional A/S Moving head light fixture with yoke and head position encoding means
US9821193B2 (en) 2012-11-01 2017-11-21 Acushnet Company Golf balls having multi-layered core with metal-containing center and thermoplastic outer layers
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
US9914387B2 (en) 2015-06-05 2018-03-13 Snap-Loc Cargo Control Systems, LLC Cargo control cinch strap system
US9805025B2 (en) 2015-07-13 2017-10-31 Seal Software Limited Standard exact clause detection
US9904473B2 (en) 2015-11-20 2018-02-27 International Business Machines Corporation Memory and processor affinity in a deduplicated environment

Also Published As

Publication number Publication date
EP1593967B1 (de) 2009-07-01
EP1141712B1 (de) 2005-07-20
ATE435423T1 (de) 2009-07-15
EP2083271A3 (de) 2009-09-09
CA2729739A1 (en) 2000-07-06
JP3566653B2 (ja) 2004-09-15
EP1141712B2 (de) 2015-12-09
DE69941068D1 (de) 2009-08-13
DE69926260T3 (de) 2016-05-19
AU775056B2 (en) 2004-07-15
DE29925020U1 (de) 2009-09-10
EP2083271A2 (de) 2009-07-29
JP2004226415A (ja) 2004-08-12
ATE300047T1 (de) 2005-08-15
WO2000039587A1 (en) 2000-07-06
DE69926260T2 (de) 2006-04-27
EP1141712A1 (de) 2001-10-10
AU2391600A (en) 2000-07-31
CA2353868A1 (en) 2000-07-06
CA2729739C (en) 2013-01-29
JP2002533727A (ja) 2002-10-08
CA2353868C (en) 2011-03-29
US20020187515A1 (en) 2002-12-12
US6998274B2 (en) 2006-02-14
US6429027B1 (en) 2002-08-06
EP1593967A3 (de) 2007-04-25
US6858394B1 (en) 2005-02-22
EP1593967A2 (de) 2005-11-09

Similar Documents

Publication Publication Date Title
DE69926260D1 (de) Kompositmatrix mit mikrokugeln
DE58903297D1 (de) Materialpruefanlage.
DE68924554D1 (de) Vielfalt-Empfänger.
DE69109939D1 (de) Flüssigkeitsgesteuerter vorgespannter Beugungshals.
NO990103D0 (no) Sensoroppstilling med forsterkning
NO891061D0 (no) Podet a-mono-olefin-kopolymer, dens fremstilling og anvendelse.
WO2001059432A3 (en) Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
NO176313C (no) Varig, stöpbart konstruksjonsmateriale
AU2002231934A1 (en) Arrayed polynucleotides and their use in genome analysis
DE58903777D1 (de) Klimapruefkammer.
CA2414618A1 (en) Composite arrays utilizing microspheres with a hybridization chamber
FI920055A0 (fi) Mikrobiologisk testanordning.
FI870147A0 (fi) Mikrobiologisk framstaellningsmetod.
DE69011142D1 (de) Kompositmaterial.
FR2715857B3 (fr) Banquette de jeu en matériau composite.
DE69012215D1 (de) Ultraschallanordnungen.
DE69923006D1 (de) Weichverbundmaterial mit hoher härte
NO972562L (no) Retnings-transduseroppstilling med höy forsterkning
NL1008938A1 (nl) Scan-verschervingswerkwijze.
DE59002197D1 (de) Mehrreihige einzelkornsaemaschine.
DE59001329D1 (de) Einzelkornsaemaschine.
DE58904132D1 (de) Einzelkornsaemaschine.
ITRM930038A0 (it) Corredo per analisi microbiologiche mediante coltura.
IT8984146A0 (it) Fertilizzante organico ad elevato contenuto proteico.
ITTO960411A0 (it) Impianto per la lavorazione di pezzi di legno, materiale sintetico e simili.

Legal Events

Date Code Title Description
8363 Opposition against the patent