DE69930729D1 - Selektion von differentiell exprimierten genen an der festphase - Google Patents
Selektion von differentiell exprimierten genen an der festphaseInfo
- Publication number
- DE69930729D1 DE69930729D1 DE69930729T DE69930729T DE69930729D1 DE 69930729 D1 DE69930729 D1 DE 69930729D1 DE 69930729 T DE69930729 T DE 69930729T DE 69930729 T DE69930729 T DE 69930729T DE 69930729 D1 DE69930729 D1 DE 69930729D1
- Authority
- DE
- Germany
- Prior art keywords
- microparticles
- sequencing
- differentially expressed
- expressed genes
- facs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US522298A | 1998-01-09 | 1998-01-09 | |
| US09/130,546 US6265163B1 (en) | 1998-01-09 | 1998-08-06 | Solid phase selection of differentially expressed genes |
| PCT/US1999/000666 WO1999035293A2 (en) | 1998-01-09 | 1999-01-08 | Solid phase selection of differentially expressed genes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69930729D1 true DE69930729D1 (de) | 2006-05-18 |
Family
ID=26674091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69930729T Expired - Lifetime DE69930729D1 (de) | 1998-01-09 | 1999-01-08 | Selektion von differentiell exprimierten genen an der festphase |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6265163B1 (de) |
| EP (1) | EP1054999B1 (de) |
| KR (1) | KR100433782B1 (de) |
| AT (1) | ATE322556T1 (de) |
| AU (1) | AU754929B2 (de) |
| CA (1) | CA2317695A1 (de) |
| DE (1) | DE69930729D1 (de) |
| NO (1) | NO20003531L (de) |
| PL (1) | PL342114A1 (de) |
| WO (1) | WO1999035293A2 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US6654505B2 (en) * | 1994-10-13 | 2003-11-25 | Lynx Therapeutics, Inc. | System and apparatus for sequential processing of analytes |
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| US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
| US6743578B1 (en) * | 1998-12-18 | 2004-06-01 | The Regents Of The University Of California | Method for the detection of specific nucleic acid sequences by polymerase nucleotide incorporation |
| US6815163B1 (en) * | 1998-12-23 | 2004-11-09 | Rutgers, The State University | Methods and kits for screening nucleic acid duplex stability |
| US7468250B2 (en) * | 1998-12-23 | 2008-12-23 | Rutgers, The State University Of New Jersey | Methods and kits for screening nucleic acid duplex stability |
| GB9905807D0 (en) * | 1999-03-12 | 1999-05-05 | Amersham Pharm Biotech Uk Ltd | Analysis of differential gene expression |
| WO2000079009A2 (en) * | 1999-06-22 | 2000-12-28 | Invitrogen Corporation | Improved primers and methods for the detection and discrimination of nucleic acids |
| US7013221B1 (en) * | 1999-07-16 | 2006-03-14 | Rosetta Inpharmatics Llc | Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays |
| GB9917027D0 (en) * | 1999-07-20 | 1999-09-22 | Affibody Technology Sweeden Ab | In vitro selection and optional identification of polypeptides using solid support carriers |
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| US6780594B2 (en) | 2000-09-25 | 2004-08-24 | Schering Aktiengesellschaft | Method for in vitro diagnosis of endometriosis |
| DE10048633A1 (de) * | 2000-09-25 | 2002-04-18 | Schering Ag | Methode zur in vitro Diagnostik von Endometriose |
| AU2001293163A1 (en) | 2000-09-27 | 2002-04-08 | Lynx Therapeutics, Inc. | Method for determining relative abundance of nucleic acid sequences |
| EP1377827A2 (de) * | 2001-04-10 | 2004-01-07 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts | Methode zur bestimmung von analytmolekülen in einer probe |
| CA2457579A1 (en) * | 2001-08-14 | 2003-02-27 | Mount Sinai School Of Medicine | Use of intrinsic reporters of cell signaling for high content drug profiling and toxicity screening |
| US20030165859A1 (en) | 2001-10-23 | 2003-09-04 | Invitrogen Corporation | Primers and methods for the detection and discrimination of nucleic acids |
| US20030170700A1 (en) * | 2002-01-09 | 2003-09-11 | Lynx Therapeutics, Inc. | Secreted and cell surface polypeptides affected by cholesterol and uses thereof |
| US20030166026A1 (en) * | 2002-01-09 | 2003-09-04 | Lynx Therapeutics, Inc. | Identification of specific biomarkers for breast cancer cells |
| AU2003238702A1 (en) * | 2002-06-12 | 2003-12-31 | Kabushiki Kaisha Dnaform | Method of utilizing the 5'end of transcribed nucleic acid regions for cloning and analysis |
| US20040086912A1 (en) * | 2002-06-21 | 2004-05-06 | Shujun Luo | Method for detecting foreign DNA in a host Genome |
| GB0218080D0 (en) * | 2002-08-03 | 2002-09-11 | Epistem Ltd | Analysis of biological samples |
| GB0218087D0 (en) * | 2002-08-03 | 2002-09-11 | Epistem Ltd | Analysis of biological samples |
| EP1582599A1 (de) * | 2004-03-31 | 2005-10-05 | Takara Bio Inc. | Verfahren zur Mikroperlenreinigung |
| US20080102455A1 (en) * | 2004-07-06 | 2008-05-01 | Genera Biosystems Pty Ltd | Method Of Detecting Aneuploidy |
| US7867703B2 (en) * | 2004-08-26 | 2011-01-11 | Agilent Technologies, Inc. | Element defined sequence complexity reduction |
| EP3543357A1 (de) | 2007-05-08 | 2019-09-25 | Trustees of Boston University | Chemische funktionalisierung von festkörpernanoporen und nanoporenarrays und anwendungen davon |
| EP2395113A1 (de) | 2007-06-29 | 2011-12-14 | Population Genetics Technologies Ltd. | Verfahren und Zusammensetzungen zur Isolierung von Nukleinsäuresequenzvarianten |
| WO2009114185A2 (en) | 2008-03-12 | 2009-09-17 | The Rockefeller University | Methods and compositions for translational profiling and molecular phenotyping |
| CN102159726A (zh) * | 2008-09-05 | 2011-08-17 | 生命科技公司 | 用于核酸测序验证、校准和标准化的方法和系统 |
| ES2555389T3 (es) | 2009-03-30 | 2015-12-30 | Illumina, Inc. | Análisis de expresión génica en células individuales |
| AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9169515B2 (en) | 2010-02-19 | 2015-10-27 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
| WO2013130674A1 (en) | 2012-02-27 | 2013-09-06 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
| WO2014190322A2 (en) | 2013-05-24 | 2014-11-27 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed fret detection |
| WO2015031691A1 (en) | 2013-08-28 | 2015-03-05 | Cellular Research, Inc. | Massively parallel single cell analysis |
| US9885079B2 (en) | 2014-10-10 | 2018-02-06 | Quantapore, Inc. | Nanopore-based polymer analysis with mutually-quenching fluorescent labels |
| WO2016065339A1 (en) | 2014-10-24 | 2016-04-28 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
| EP3259371B1 (de) | 2015-02-19 | 2020-09-02 | Becton, Dickinson and Company | Hochdurchsatzeinzelzellenanalyse mit kombination von proteomischen und genomischen informationen |
| US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| CN107406888A (zh) | 2015-03-30 | 2017-11-28 | 赛卢拉研究公司 | 用于组合条形编码的方法和组合物 |
| EP3286326A1 (de) | 2015-04-23 | 2018-02-28 | Cellular Research, Inc. | Verfahren und zusammensetzungen zur gesamttranskriptomamplifikation |
| WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
| JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ， インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
| JP6417603B2 (ja) | 2016-01-27 | 2018-11-07 | 株式会社ダナフォーム | Ｒｎａの末端領域に対応する核酸の塩基配列を解読する方法およびｄｎａエレメントの分析方法 |
| EP3452614B1 (de) | 2016-05-02 | 2023-06-28 | Becton, Dickinson and Company | Genaue molekulare barcodierung |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| CN109074430B (zh) | 2016-05-26 | 2022-03-29 | 贝克顿迪金森公司 | 分子标记计数调整方法 |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| KR101879329B1 (ko) * | 2016-06-13 | 2018-07-17 | 충북대학교 산학협력단 | 유전자 차별 발현 분석을 위한 RNA-seq 발현량 데이터 시뮬레이션 방법 및 이를 기록한 기록매체 |
| JP2019522983A (ja) | 2016-07-05 | 2019-08-22 | クアンタポール， インコーポレイテッド | 光学ベースのナノポア配列決定 |
| AU2017331459B2 (en) | 2016-09-26 | 2023-04-13 | Becton, Dickinson And Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| US10722880B2 (en) | 2017-01-13 | 2020-07-28 | Cellular Research, Inc. | Hydrophilic coating of fluidic channels |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| CN110719959B (zh) | 2017-06-05 | 2021-08-06 | 贝克顿迪金森公司 | 针对单细胞的样品索引 |
| WO2019126209A1 (en) | 2017-12-19 | 2019-06-27 | Cellular Research, Inc. | Particles associated with oligonucleotides |
| AU2019262048A1 (en) | 2018-05-03 | 2020-11-12 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
| JP7358388B2 (ja) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | 反対側の転写物末端における分子バーコーディング |
| WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
| JP2022506546A (ja) | 2018-11-08 | 2022-01-17 | ベクトン・ディキンソン・アンド・カンパニー | ランダムプライミングを使用した単一細胞の全トランスクリプトーム解析 |
| US11492660B2 (en) | 2018-12-13 | 2022-11-08 | Becton, Dickinson And Company | Selective extension in single cell whole transcriptome analysis |
| US11371076B2 (en) | 2019-01-16 | 2022-06-28 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| EP4242322A3 (de) | 2019-01-23 | 2023-09-20 | Becton, Dickinson and Company | Mit antikörpern assoziierte oligonukleotide |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| WO2021092386A1 (en) | 2019-11-08 | 2021-05-14 | Becton Dickinson And Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
| EP4090763A1 (de) | 2020-01-13 | 2022-11-23 | Becton Dickinson and Company | Verfahren und zusammensetzungen zur quantifizierung von proteinen und rna |
| CN115605614A (zh) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司（Us） | 用于免疫组库谱分析的引物 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| EP4247967A1 (de) | 2020-11-20 | 2023-09-27 | Becton, Dickinson and Company | Profilierung von stark exprimierten und schwach exprimierten proteinen |
| DE102021134368B4 (de) | 2021-12-22 | 2023-09-21 | Hochschule Reutlingen Körperschaft des öffentlichen Rechts | Vorrichtung und Verfahren zur Detektion von markierten Tumorzellen eines Gewebes in einer strömenden Flüssigkeit |
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| BE793185A (fr) | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
| US4354114A (en) | 1979-10-09 | 1982-10-12 | Karnaukhov Valery N | Apparatus for investigation of fluorescence characteristics of microscopic objects |
| US4812394A (en) | 1983-10-18 | 1989-03-14 | University Of California | Flow cytomeric measurement of DNA and incorporated nucleoside analogs |
| US5206143A (en) | 1985-11-01 | 1993-04-27 | Smithkline Beecham Corporation | Method and reagents for performing subset analysis using quantitative differences in fluorescence intensity |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
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| SE458968B (sv) | 1987-06-16 | 1989-05-22 | Wallac Oy | Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser |
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-
1998
- 1998-08-06 US US09/130,546 patent/US6265163B1/en not_active Expired - Lifetime
-
1999
- 1999-01-08 WO PCT/US1999/000666 patent/WO1999035293A2/en active IP Right Grant
- 1999-01-08 CA CA002317695A patent/CA2317695A1/en not_active Abandoned
- 1999-01-08 EP EP99901448A patent/EP1054999B1/de not_active Expired - Lifetime
- 1999-01-08 US US09/227,694 patent/US6511802B1/en not_active Expired - Lifetime
- 1999-01-08 DE DE69930729T patent/DE69930729D1/de not_active Expired - Lifetime
- 1999-01-08 PL PL99342114A patent/PL342114A1/xx unknown
- 1999-01-08 AT AT99901448T patent/ATE322556T1/de not_active IP Right Cessation
- 1999-01-08 AU AU21139/99A patent/AU754929B2/en not_active Ceased
- 1999-01-08 KR KR10-2000-7007585A patent/KR100433782B1/ko not_active IP Right Cessation
-
2000
- 2000-07-07 NO NO20003531A patent/NO20003531L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003531L (no) | 2000-09-05 |
| AU754929B2 (en) | 2002-11-28 |
| NO20003531D0 (no) | 2000-07-07 |
| EP1054999A2 (de) | 2000-11-29 |
| CA2317695A1 (en) | 1999-07-15 |
| US6265163B1 (en) | 2001-07-24 |
| ATE322556T1 (de) | 2006-04-15 |
| PL342114A1 (en) | 2001-05-21 |
| WO1999035293A2 (en) | 1999-07-15 |
| WO1999035293A3 (en) | 1999-09-30 |
| EP1054999B1 (de) | 2006-04-05 |
| US6511802B1 (en) | 2003-01-28 |
| KR20010033992A (ko) | 2001-04-25 |
| KR100433782B1 (ko) | 2004-06-04 |
| AU2113999A (en) | 1999-07-26 |
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