DE69932600D1 - Zusammensetzungen und verfahren zur behandlung von tumoren - Google Patents
Zusammensetzungen und verfahren zur behandlung von tumorenInfo
- Publication number
- DE69932600D1 DE69932600D1 DE69932600T DE69932600T DE69932600D1 DE 69932600 D1 DE69932600 D1 DE 69932600D1 DE 69932600 T DE69932600 T DE 69932600T DE 69932600 T DE69932600 T DE 69932600T DE 69932600 D1 DE69932600 D1 DE 69932600D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- erb
- individual
- disclosed
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7678898P | 1998-03-04 | 1998-03-04 | |
US76788P | 1998-03-04 | ||
US09/111,681 US6417168B1 (en) | 1998-03-04 | 1998-07-08 | Compositions and methods of treating tumors |
US111681 | 1998-07-08 | ||
PCT/US1999/004777 WO1999044645A1 (en) | 1998-03-04 | 1999-03-04 | Compositions and methods of treating tumors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69932600D1 true DE69932600D1 (de) | 2006-09-14 |
DE69932600T2 DE69932600T2 (de) | 2007-08-09 |
Family
ID=26758479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69932600T Expired - Lifetime DE69932600T2 (de) | 1998-03-04 | 1999-03-04 | Zusammensetzungen und verfahren zur behandlung von tumoren |
Country Status (13)
Country | Link |
---|---|
US (8) | US6417168B1 (de) |
EP (2) | EP3034093B1 (de) |
JP (2) | JP2002505309A (de) |
AT (1) | ATE334702T1 (de) |
AU (1) | AU757237C (de) |
CA (1) | CA2322592A1 (de) |
CY (1) | CY1105475T1 (de) |
DE (1) | DE69932600T2 (de) |
DK (1) | DK1058562T3 (de) |
ES (2) | ES2270586T3 (de) |
HK (1) | HK1225997A1 (de) |
PT (1) | PT1058562E (de) |
WO (1) | WO1999044645A1 (de) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
ATE278794T1 (de) | 1995-06-15 | 2004-10-15 | Crucell Holland Bv | Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
EP1745799B1 (de) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Zusammensetzungen und Verfahren zur Behandlung von Tumoren |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US7393823B1 (en) | 1999-01-20 | 2008-07-01 | Oregon Health And Science University | HER-2 binding antagonists |
US7625859B1 (en) * | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
US7396810B1 (en) | 2000-08-14 | 2008-07-08 | Oregon Health Sciences University | Compositions and methods for treating cancer by modulating HER-2 and EGF receptors |
AU782994C (en) * | 1999-05-14 | 2006-08-24 | Imclone Llc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
DK1189634T3 (da) * | 1999-06-25 | 2007-06-25 | Genentech Inc | Behandling af prostatacancer med anti-ErbB2-antistoffer |
EP1280923A2 (de) * | 2000-04-28 | 2003-02-05 | Millennium Pharmaceuticals, Inc. | 14094, ein angehörige der menschlichen trypsin-familie, und dessen verwendungen |
AU9500201A (en) * | 2000-08-09 | 2002-02-18 | Imclone Systems Inc | Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists |
US20100282634A1 (en) * | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US8039261B2 (en) * | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20070286845A1 (en) * | 2000-11-17 | 2007-12-13 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20050239738A1 (en) * | 2000-11-17 | 2005-10-27 | Rupert Schmidt-Ullrich | Genetic inhibition of epidermal growth factor receptor function and carcinoma cell radiosensitization |
US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
JP4398644B2 (ja) * | 2001-04-06 | 2010-01-13 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | ErbB界面ペプチド擬態およびその使用方法 |
ES2552281T3 (es) | 2001-05-11 | 2015-11-26 | Ludwig Institute For Cancer Research Ltd. | Proteínas de unión específica y usos de las mismas |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
AU2002326531A1 (en) * | 2001-08-03 | 2003-02-17 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbb family members and methods of use thereof |
AU2002365258A1 (en) * | 2001-10-12 | 2003-09-02 | University Of Vermont And State Agricultural College | Binding peptides specific for the extracellular domain of erbb2 and uses therefor |
EP1436313B1 (de) * | 2001-10-19 | 2010-09-22 | Vascular Biogenics Ltd. | Polynukleotidkonstrukte, pharmazeutische zusammensetzungen und verfahren zur gezielten herunterregulierung von angiogenese und zur krebstherapie |
AU2002365396A1 (en) * | 2001-11-21 | 2003-06-10 | The Trustees Of The University Of Pennsylvania | Peptides, peptide compositions,and methods of use in binding p 185 |
EA010828B1 (ru) * | 2002-04-25 | 2008-12-30 | Круселл Холланд Б.В. | Рекомбинантный аденовирусный вектор и способы его получения и применения |
US20030202973A1 (en) * | 2002-04-29 | 2003-10-30 | Dr. George Pieczenik | Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists |
US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
EP1513543B1 (de) | 2002-05-23 | 2010-10-06 | The Trustees of The University of Pennsylvania | Fas peptid-mimetika und ihre verwendungszwecke |
WO2004005320A2 (en) * | 2002-07-03 | 2004-01-15 | The Curators Of The University Of Missouri | ErbB-2 RECEPTOR TARGETING PEPTIDE |
ES2376165T3 (es) * | 2002-07-15 | 2012-03-09 | F. Hoffmann-La Roche Ag | Tratamiento del c�?ncer con el anticuerpo dirigido contra erbb2 rhumab 2c4. |
CA2506320A1 (en) * | 2002-11-21 | 2004-06-10 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies |
EP1622941A2 (de) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Methode zur produktion von anti-egfr antikörpern |
EP1613205B1 (de) * | 2003-04-01 | 2013-04-24 | Monogram BioSciences, Inc. | Erbb-oberflächen-rezeptor-komplexe als biomarker |
WO2005037071A2 (en) * | 2003-10-14 | 2005-04-28 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
JP4734319B2 (ja) * | 2004-03-19 | 2011-07-27 | イムクローン・リミテッド・ライアビリティ・カンパニー | ヒト抗上皮成長因子受容体抗体 |
US20110142822A1 (en) * | 2004-06-14 | 2011-06-16 | Kussie Paul H | Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof |
WO2006042002A2 (en) * | 2004-10-05 | 2006-04-20 | Oregon Health And Science University | Compositions and methods for treating disease |
US20070009972A1 (en) * | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
BRPI0606542A8 (pt) | 2005-02-23 | 2018-03-20 | Genentech Inc | métodos para aumentar o tempo de progressão de uma doença (ttp) |
WO2006096861A2 (en) * | 2005-03-08 | 2006-09-14 | Genentech, Inc. | METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs) |
WO2008089448A2 (en) | 2007-01-19 | 2008-07-24 | Cornell Presearch Foundation, Inc. | Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis |
WO2008091701A2 (en) | 2007-01-25 | 2008-07-31 | Dana-Farber Cancer Institute | Use of anti-egfr antibodies in treatment of egfr mutant mediated disease |
PT2129396E (pt) | 2007-02-16 | 2013-11-18 | Merrimack Pharmaceuticals Inc | Anticorpos contra erbb3 e suas utilizações |
CA2677108A1 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her inhibitor |
MX2009009782A (es) | 2007-03-15 | 2010-09-10 | Ludwig Inst Cancer Res | Metodo de tratamiento que utiliza anticuerpos egfr e inhibidores de src y formulaciones relacionadas. |
CA3006428A1 (en) | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
AU2008312580A1 (en) * | 2007-10-16 | 2009-04-23 | Symphogen A/S | Compositions comprising optimized Her1 and Her3 multimers and methods of use thereof |
US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
NZ586701A (en) | 2008-01-03 | 2013-07-26 | Scripps Research Inst | Antibody targeting through a modular recognition domain (MRD) wherein the MRD targets angiopoietin-2 (ANG-2) |
US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
UA104868C2 (uk) * | 2008-08-15 | 2014-03-25 | Меррімак Фармасьютікалз, Інк. | Спосіб лікування пацієнта, що має неопластичну пухлину, відповідно до спрогнозованої реакції |
JP2012507299A (ja) * | 2008-10-31 | 2012-03-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Light標的分子およびその使用 |
US20120121596A1 (en) | 2009-03-20 | 2012-05-17 | Germaine Fuh | Bispecific anti-her antibodies |
EP2859893A1 (de) | 2010-03-11 | 2015-04-15 | Merrimack Pharmaceuticals, Inc. | Verwendung von ERBB3-Hemmern bei der Behandlung von dreifach negativem und basalem Brustkrebs |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
IL299365A (en) | 2010-05-27 | 2023-02-01 | Genmab As | Monoclonal antibodies against 2HER |
NZ604007A (en) | 2010-05-27 | 2015-03-27 | Genmab As | Monoclonal antibodies against her2 epitope |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
US9427458B2 (en) * | 2010-07-22 | 2016-08-30 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas, Conicet | Methods for inhibiting cancer cell proliferation |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
US20140170149A1 (en) | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
CN103857699B (zh) | 2011-05-24 | 2016-08-31 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
AU2012340081A1 (en) | 2011-11-17 | 2014-05-01 | Bayer Healthcare Llc | Methods and techniques for collecting, reporting, and managing information about medical diagnostic procedures |
EP2797957B1 (de) | 2011-11-23 | 2019-06-19 | MedImmune, LLC | Her3-spezifische bindungsmoleküle und verwendungen davon |
CN104271761B (zh) | 2011-11-30 | 2017-03-15 | 霍夫曼-拉罗奇有限公司 | 癌症中的erbb3突变 |
ES2842201T3 (es) * | 2012-02-23 | 2021-07-13 | Daiichi Sankyo Europe Gmbh | Inhibidor de HER3 para modulación de radiosensibilidad |
JP2015514710A (ja) | 2012-03-27 | 2015-05-21 | ジェネンテック, インコーポレイテッド | Her3阻害剤に関する診断及び治療 |
US9878055B2 (en) | 2013-03-14 | 2018-01-30 | Georgetown University | Treatment for exposure to nerve agent |
EP3424530A1 (de) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalente und monovalente multispezifische komplexe und deren verwendungen |
US11446516B2 (en) | 2013-08-09 | 2022-09-20 | The Trustees Of The University Of Pennsylvania | Methods of increasing response to cancer radiation therapy |
EP3030268B1 (de) * | 2013-08-09 | 2022-07-27 | The Trustees Of The University Of Pennsylvania | Kombination von ifn-gamma mit anti-erbb-antikörpern zur krebsbehandlung |
US11305012B2 (en) | 2013-09-24 | 2022-04-19 | Medimmune, Llc | Binding molecules specific for HER3 and uses thereof |
WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
CA2953376C (en) * | 2014-06-27 | 2024-02-06 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus e4orf1, and methods of making and using the same |
EP3283111A4 (de) * | 2015-04-17 | 2019-04-17 | Celldex Therapeutics, Inc. | Biomarker im zusammenhang mit behandlung von krebs mit her3 und egfr-inhibitoren |
US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
CN110536969A (zh) | 2017-04-24 | 2019-12-03 | 豪夫迈·罗氏有限公司 | 跨膜或近膜域中的erbb2/her2突变 |
WO2019010243A1 (en) | 2017-07-07 | 2019-01-10 | Bayer Healthcare Llc | APPARATUS, METHOD AND COMPUTER PROGRAM PRODUCT FOR EXCHANGING DATA EXCHANGE BETWEEN INJECTION SYSTEMS |
WO2019185164A1 (en) | 2018-03-29 | 2019-10-03 | Hummingbird Bioscience Holdings Pte. Ltd. | Her3 antigen-binding molecules |
CA3209779A1 (en) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
CA3231706A1 (en) * | 2021-09-13 | 2023-03-16 | The Board Of Regents Of The University Of Texas System | Lilrb2-specific monoclonal antibodies and methods of their use |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US600377A (en) * | 1898-03-08 | Spring saddle-post | ||
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4394448A (en) | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US4241046A (en) | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
AU583801B2 (en) * | 1983-10-26 | 1989-05-11 | Sheldon B. Greer | Method and materials for sensitizing neoplastic tissue to radiation |
US5637677A (en) * | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
US5470571A (en) | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
US5200178A (en) | 1988-02-26 | 1993-04-06 | The General Hospital Corporation | Method for tumor detection |
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
EP0527802B1 (de) | 1990-04-06 | 1997-06-04 | The Trustees Of The University Of Pennsylvania | Ligand für das neu-gen-produkt |
US5367060A (en) | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
WO1993014781A1 (en) | 1992-01-24 | 1993-08-05 | The Regents Of The University Of California | Novel peptides and method for altering the activity of allosteric proteins |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
EP0616812B1 (de) | 1993-03-24 | 1999-11-03 | Berlex Biosciences | Kombination von Antihormonale und bindende Moleküle zur Krebsbehandlung |
US6733752B1 (en) * | 1994-03-30 | 2004-05-11 | The Trustees Of The University Of Pennsylvania | Prevention of tumors with monoclonal antibodies against neu |
WO1994022478A1 (en) * | 1993-03-30 | 1994-10-13 | The Trustees Of The University Of Pennsylvania | PREVENTION OF TUMORS WITH MONOCLONAL ANTIBODIES AGAINST $i(NEU) |
GB9401182D0 (en) | 1994-01-21 | 1994-03-16 | Inst Of Cancer The Research | Antibodies to EGF receptor and their antitumour effect |
WO1995024190A2 (en) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
WO1995030331A1 (en) | 1994-05-05 | 1995-11-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
US6100377A (en) | 1994-06-10 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Constrained peptides |
US5707618A (en) | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
EP0740187B1 (de) | 1995-04-28 | 2004-06-23 | Hewlett-Packard Company, A Delaware Corporation | Elektrooptische Anzeigevorrichtung |
US5663144A (en) | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
US5756283A (en) | 1995-06-05 | 1998-05-26 | The Trustees Of The University Of Pennsylvania | Method for improved production of recombinant adeno-associated viruses for gene therapy |
US6281010B1 (en) | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
EP0831880A4 (de) | 1995-06-07 | 2004-12-01 | Imclone Systems Inc | Antikörper und deren fragmente zur hemmung von tumorwachstum |
AU727082B2 (en) * | 1996-03-27 | 2000-11-30 | Genentech Inc. | ErbB3 antibodies |
ATE486937T1 (de) | 1996-07-12 | 2010-11-15 | Genentech Inc | Chimärische heteromultimerische adhesine |
WO1998017797A1 (en) | 1996-10-18 | 1998-04-30 | Genentech, Inc. | ANTI-ErbB2 ANTIBODIES |
WO1998018489A1 (en) | 1996-10-30 | 1998-05-07 | The Uab Research Foundation | Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain intracellular antibodies |
US6074640A (en) * | 1997-10-30 | 2000-06-13 | Uab Research Foundation | Enhancement of tumor cell radiosensitivity using single chain intracellular antibodies |
US6027892A (en) * | 1996-12-30 | 2000-02-22 | Chang Esther H | Compositions and methods for reducing radiation and drug resistance in cells |
US6235883B1 (en) * | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
EP1745799B1 (de) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Zusammensetzungen und Verfahren zur Behandlung von Tumoren |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
SK17282000A3 (sk) | 1998-05-15 | 2002-04-04 | Imclone Systems Incorporated | Nerádioaktívne označený inhibítor proteínového tyrozínkynázového receptora |
DE10124566A1 (de) | 2001-05-15 | 2002-11-21 | Zeiss Carl | Optisches Abbildungssystem mit Polarisationsmitteln und Quarzkristallplatte hierfür |
US6828474B2 (en) | 2002-03-06 | 2004-12-07 | National Starch & Chemical Investment Holding Corporation | Method of grain production for heterozygous waxy sugary-2 maize |
US8561398B2 (en) | 2009-05-05 | 2013-10-22 | Florida Renewable Energy Corporation | Fluid-based power generation system |
HUE045467T2 (hu) | 2011-03-14 | 2020-01-28 | Drug Delivery Solutions Ltd | Szemészeti készítmény |
US9507157B2 (en) | 2014-12-17 | 2016-11-29 | Zhen Tang | Size-adjustable elliptical laser marker |
TWI713998B (zh) | 2019-02-22 | 2020-12-21 | 南亞塑膠工業股份有限公司 | 一種含二氧化鈦漿料的製作及應用於回收聚酯纖維 |
-
1998
- 1998-07-08 US US09/111,681 patent/US6417168B1/en not_active Expired - Lifetime
-
1999
- 1999-03-04 PT PT99908641T patent/PT1058562E/pt unknown
- 1999-03-04 DE DE69932600T patent/DE69932600T2/de not_active Expired - Lifetime
- 1999-03-04 AU AU28021/99A patent/AU757237C/en not_active Expired
- 1999-03-04 AT AT99908641T patent/ATE334702T1/de active
- 1999-03-04 ES ES99908641T patent/ES2270586T3/es not_active Expired - Lifetime
- 1999-03-04 EP EP15183218.5A patent/EP3034093B1/de not_active Revoked
- 1999-03-04 CA CA002322592A patent/CA2322592A1/en not_active Expired - Lifetime
- 1999-03-04 ES ES06076149.1T patent/ES2551932T3/es not_active Expired - Lifetime
- 1999-03-04 EP EP99908641A patent/EP1058562B1/de not_active Revoked
- 1999-03-04 JP JP2000534245A patent/JP2002505309A/ja active Pending
- 1999-03-04 WO PCT/US1999/004777 patent/WO1999044645A1/en active IP Right Grant
- 1999-03-04 DK DK99908641T patent/DK1058562T3/da active
-
2002
- 2002-03-19 US US10/100,952 patent/US7625558B2/en not_active Expired - Lifetime
-
2006
- 2006-09-14 CY CY20061101312T patent/CY1105475T1/el unknown
-
2008
- 2008-05-02 US US12/114,475 patent/US20090010935A1/en not_active Abandoned
-
2011
- 2011-04-05 US US13/080,313 patent/US20120014965A1/en not_active Abandoned
- 2011-10-11 JP JP2011224347A patent/JP5719270B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-12 US US13/796,468 patent/US20130204069A1/en not_active Abandoned
-
2014
- 2014-09-12 US US14/485,525 patent/US20150010551A1/en not_active Abandoned
-
2015
- 2015-06-03 US US14/729,798 patent/US20160289334A2/en not_active Abandoned
-
2016
- 2016-12-21 HK HK16114528A patent/HK1225997A1/zh unknown
-
2017
- 2017-02-01 US US15/422,046 patent/US20170355778A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20150010551A1 (en) | 2015-01-08 |
US20090010935A1 (en) | 2009-01-08 |
DE69932600T2 (de) | 2007-08-09 |
EP1058562A4 (de) | 2003-02-05 |
AU757237B2 (en) | 2003-02-06 |
JP5719270B2 (ja) | 2015-05-13 |
AU2802199A (en) | 1999-09-20 |
AU757237C (en) | 2004-03-18 |
WO1999044645A1 (en) | 1999-09-10 |
US7625558B2 (en) | 2009-12-01 |
US20160083478A1 (en) | 2016-03-24 |
JP2012017341A (ja) | 2012-01-26 |
CA2322592A1 (en) | 1999-09-10 |
US20120014965A1 (en) | 2012-01-19 |
DK1058562T3 (da) | 2006-11-13 |
US20170355778A1 (en) | 2017-12-14 |
US6417168B1 (en) | 2002-07-09 |
HK1225997A1 (zh) | 2017-09-22 |
EP1058562A1 (de) | 2000-12-13 |
US20160289334A2 (en) | 2016-10-06 |
EP3034093A1 (de) | 2016-06-22 |
ATE334702T1 (de) | 2006-08-15 |
ES2551932T3 (es) | 2015-11-24 |
PT1058562E (pt) | 2006-11-30 |
CY1105475T1 (el) | 2010-04-28 |
ES2270586T3 (es) | 2007-04-01 |
EP1058562B1 (de) | 2006-08-02 |
JP2002505309A (ja) | 2002-02-19 |
US20130204069A1 (en) | 2013-08-08 |
US20020165193A1 (en) | 2002-11-07 |
EP3034093B1 (de) | 2019-03-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69932600D1 (de) | Zusammensetzungen und verfahren zur behandlung von tumoren | |
DE3587939D1 (de) | Tumornekrosefaktor, Verfahren zu seiner Herstellung, denselben enthaltende Zusammensetzungen, dafür kodierende DNS und diese DNS verwendendes Testverfahren. | |
DE69733968D1 (de) | Norbornen- und norbornandiolen zur behandlung von pigmentierungsstörungen, neurodegenerativen erkrankungen oder proliferativen hauterkrankungen | |
DE69127175D1 (de) | Antisens-Oligonukleotide zur Behandlung von Krebs | |
ATE186219T1 (de) | Kombination von antihormonale und bindende moleküle zur krebsbehandlung | |
ATE519862T1 (de) | Zusammensetzungen, kits und verfahren zur identifizierung, beurteilung, vorbeugung und therapie von gebärmutterhalskrebs | |
DE69826695D1 (de) | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen | |
ATE399553T1 (de) | Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen | |
ATE153696T1 (de) | Verfahren und desoxyribonukleinsäure zur herstellung von gewebefaktor-protein | |
ATE257392T1 (de) | Verfahren zur modulierung der neovaskularisierung und/oder des wachstums von kollateraler arterien und / oder anderer arterien aus bestehenden arteriolären verbindungen | |
ATE350030T1 (de) | Nordihydroguaiaretinsäurederivate zur behandlung von tumoren | |
ATE260282T1 (de) | Aromatische ester von camptothecinen und verfahren zur behandlung von krebserkrankungen | |
DE69535673D1 (de) | Mittel zur induktion von apoptosis und zur therapieanwendung | |
ATE386535T1 (de) | Hapten modifizierter tumorzellextrakt und verfahren zur behandlung von krebs | |
DE69510356D1 (de) | Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie | |
ATE313561T1 (de) | Vgf polypeptide und verfahren zur behandlung von vgf-erkrankungen | |
DE69932922D1 (de) | Verwendung von alkansäuren-enthaltenden zusammensetzungen zur behandlung von nagelpilz-erkrankungen | |
ATE367806T1 (de) | Mittel und verfahren zur vorbeugung von durch chemotherapie ausgelöster alopezie | |
EP1745799A3 (de) | Zusammensetzungen und Verfahren zur Behandlung von Tumoren | |
DE60135232D1 (de) | Nukleinsäure und korrespondierendes protein 85p1b3, nützlich zur behandlung und detektion von krebserkrankungen | |
DE60224778D1 (de) | Zusammensetzungen und Verfahren zur Behandlung und zur Detektion von proliferativen Störungen die mit der Überexpression des menschlichen "Transketolase like-1" gens in Zusammenhang stehen | |
ATE100319T1 (de) | Verwendung von chinolyl-und isochinolyloxazol-2- onen zur herstellung eines arzneinmittels zur behandlung von gegen eine vielzahl von arzneimitteln resistenten tumoren. | |
ATE219941T1 (de) | Verwendung von cytokinen und cytotoxischen substanzen in einem neuen verfahren zur tumorbehandlung | |
ATE136776T1 (de) | Verwendung von heptastigmin zur behandlung der zerebralen ictus | |
DE60037349D1 (de) | Zusammensetzungen und Verfahren zur Behandlung von Tumoren |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |