DE69942342D1 - Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen - Google Patents
Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungenInfo
- Publication number
- DE69942342D1 DE69942342D1 DE69942342T DE69942342T DE69942342D1 DE 69942342 D1 DE69942342 D1 DE 69942342D1 DE 69942342 T DE69942342 T DE 69942342T DE 69942342 T DE69942342 T DE 69942342T DE 69942342 D1 DE69942342 D1 DE 69942342D1
- Authority
- DE
- Germany
- Prior art keywords
- benzyl
- saccharide
- amine
- carboxylic acid
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10154298P | 1998-09-23 | 1998-09-23 | |
PCT/US1999/021778 WO2000016772A1 (en) | 1998-09-23 | 1999-09-23 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69942342D1 true DE69942342D1 (de) | 2010-06-17 |
Family
ID=22285189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69942342T Expired - Lifetime DE69942342D1 (de) | 1998-09-23 | 1999-09-23 | Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen |
Country Status (16)
Country | Link |
---|---|
US (2) | US6417223B1 (de) |
EP (1) | EP1115398B1 (de) |
JP (1) | JP2002526446A (de) |
KR (1) | KR100712383B1 (de) |
CN (2) | CN1195513C (de) |
AT (1) | ATE466850T1 (de) |
AU (1) | AU757013B2 (de) |
CA (1) | CA2345079C (de) |
DE (1) | DE69942342D1 (de) |
DK (1) | DK1115398T3 (de) |
IL (1) | IL142082A (de) |
NZ (1) | NZ510732A (de) |
RU (1) | RU2232758C2 (de) |
TW (1) | TW592695B (de) |
WO (1) | WO2000016772A1 (de) |
ZA (1) | ZA200102057B (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6703384B2 (en) * | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US6048891A (en) * | 1998-12-17 | 2000-04-11 | Loma Linda University Medical Center | Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of natriuretic disease |
KR20010055765A (ko) * | 1999-12-13 | 2001-07-04 | 이경하 | 3-메틸-크로만 또는 티오크로만 유도체 |
EP1241165A4 (de) * | 1999-12-13 | 2003-03-19 | Chugai Pharmaceutical Co Ltd | Optisch aktive chroman- und thiochromanderivate |
KR20010055766A (ko) * | 1999-12-13 | 2001-07-04 | 이경하 | 3-메틸-크로만 또는 티오크로만 유도체의 금속염 |
EP1241167A4 (de) * | 1999-12-13 | 2003-03-26 | Chugai Pharmaceutical Co Ltd | 3-ethyl, 3-propyl- oder 3-butyl-chroman und -thiochromanderivate |
ATE382615T1 (de) * | 2000-02-11 | 2008-01-15 | Res Dev Foundation | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
AU2000267372A1 (en) * | 2000-08-23 | 2002-03-22 | Jisoo Kim | Polyoxyethylene-polyoxypropylene vitamin e and process for preparation thereof |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
EP1339413B1 (de) * | 2000-11-14 | 2009-10-07 | Vital Health Sciences Pty Ltd. | Zusammensetzungen umfassend Komplexe von Tocopherolphosphatderivaten |
US8008345B2 (en) * | 2001-07-27 | 2011-08-30 | Vital Health Sciences Pty. Ltd. | Dermal therapy using phosphate derivatives of electron transfer agents |
BR0213094A (pt) * | 2001-10-04 | 2004-10-13 | Wyeth Corp | Derivados de cromano como ligandos de 5-hidroxi-triptamina-6 |
CN1604772A (zh) * | 2001-12-13 | 2005-04-06 | 生命健康科学有限公司 | 化合物的透皮转运 |
CN100515497C (zh) * | 2001-12-19 | 2009-07-22 | 研究发展基金会 | 脂质体输送以维生素e为基础的化合物 |
US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
US20040034093A1 (en) * | 2002-05-30 | 2004-02-19 | Hensley Kenneth L. | Methods for enhancing motor performance and/or endurance |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
EP1589964B1 (de) * | 2003-01-17 | 2011-11-23 | Vital Health Sciences Pty Ltd. | Verbindungen mit proliferationshemmenden eigenschaften |
AU2003900200A0 (en) * | 2003-01-17 | 2003-01-30 | Vital Health Sciences Pty Ltd | Compounds having antiproliferative properties |
US6716873B1 (en) * | 2003-03-20 | 2004-04-06 | Yasoo Health Inc. | Tocopherol ester compounds |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
US7514461B2 (en) * | 2003-09-19 | 2009-04-07 | Edison Pharmaceuticals, Inc. | Chroman derivatives |
US20050080109A1 (en) * | 2003-10-09 | 2005-04-14 | Papas Andreas M. | Gamma-tocopherol and gamma-tocotrienol therapy for multiple sclerosis |
BRPI0415858A (pt) * | 2003-10-29 | 2007-01-09 | Sonus Pharma Inc | compostos de medicamentos terapêuticos modificados por tocoferol |
US20080045559A1 (en) * | 2003-10-29 | 2008-02-21 | Sonus Pharmaceuticals, Inc. | Tocopherol-modified therapeutic drug compounds |
JP4847437B2 (ja) * | 2004-03-03 | 2011-12-28 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | アルカロイド製剤 |
US20060165769A1 (en) * | 2004-09-30 | 2006-07-27 | Hyatt John A | Pharmaceutical formulations containing vitamin E TPGS molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
EP1858508A4 (de) * | 2005-03-03 | 2009-01-07 | Vital Health Sciences Pty Ltd | Verbindungen mit krebshemmenden eigenschaften |
CN100334080C (zh) * | 2005-06-01 | 2007-08-29 | 华东理工大学 | 苯并二氢吡喃碳糖苷衍生物 |
KR20080019228A (ko) * | 2005-06-17 | 2008-03-03 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 하나 이상의 디 및/또는 모노-(전자전달제) 인산염 유도체또는 그의 착염을 함유하는 담체 |
CA2631653A1 (en) * | 2005-12-23 | 2007-06-28 | Vital Health Sciences Pty Ltd. | Compounds having cytokine modulating properties |
US20080009545A1 (en) * | 2006-02-21 | 2008-01-10 | The Ohio State University Research Foundation | Anticancer agents |
WO2007143081A2 (en) * | 2006-06-02 | 2007-12-13 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of lymphoid malignancies |
US8288369B2 (en) * | 2006-06-27 | 2012-10-16 | University Of South Florida | Delta-tocotrienol treatment and prevention of pancreatic cancer |
US20100292316A1 (en) * | 2007-07-18 | 2010-11-18 | Research Development Foundation | Improved therapeutic methods and compositions comprising chroman ring compounds |
CN102171215B (zh) * | 2008-11-05 | 2014-06-18 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
EP2419414A4 (de) * | 2009-04-13 | 2013-12-04 | Univ Ohio State Res Found | Mittel zur aktivierung der protein-phosphatase 2a |
WO2010121111A1 (en) * | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
KR20180056816A (ko) * | 2009-05-11 | 2018-05-29 | 베르그 엘엘씨 | 환경대사적 전환인자(조효소 q10)를 사용한 질환의 치료 방법 |
US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
WO2011120084A1 (en) | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
EP2685992A4 (de) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Aminochinoline als kinasehemmer |
CN102516258B (zh) * | 2011-11-11 | 2014-06-25 | 正大天晴药业集团股份有限公司 | 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用 |
RU2613110C2 (ru) * | 2012-05-18 | 2017-03-15 | Те Огайо Стейт Юниверсити | Способы улучшения функции печени |
CA2911149A1 (en) * | 2013-05-02 | 2014-11-06 | The Chancellor, Masters And Scholars Of The University Of Oxford | Glycolipid inhibition using iminosugars |
PL3041831T3 (pl) | 2013-09-06 | 2021-07-19 | Research Development Foundation | Postacie soli alfa-TEA: kompozycje i zastosowania do leczenia choroby |
US9993456B2 (en) | 2013-09-13 | 2018-06-12 | The Board Of Trustees Of The University Of Arkansas | Preparation and use of a composition for prevention and mitigation of the effects of radiation |
ES2643407T3 (es) * | 2014-02-07 | 2017-11-22 | Novogen Ltd. | Compuestos de benzopirano funcionalizados y uso de los mismos |
RU2571094C1 (ru) * | 2015-02-11 | 2015-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный университет им. Ф.М. Достоевского" | СПОСОБ ПОЛУЧЕНИЯ 4-АЛКОКСИ-4Н-ТИЕНО[3,2-с]ХРОМЕН-2-КАРБАЛЬДЕГИДОВ, ОБЛАДАЮЩИХ ПРОТИВОЯЗВЕННОЙ АКТИВНОСТЬЮ |
US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
KR102647670B1 (ko) | 2016-12-21 | 2024-03-15 | 아베초 바이오테크놀로지 리미티드 | 방법 |
WO2019210422A1 (en) * | 2018-05-04 | 2019-11-07 | Exact Delivery Inc. | Vitamin e derivatives and their use as multi-scale imaging agents |
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JPS5118954B2 (de) * | 1972-02-04 | 1976-06-14 | ||
CS172015B1 (de) * | 1974-05-12 | 1976-12-29 | ||
EP0008573A1 (de) * | 1977-12-16 | 1980-03-05 | Nisshin Flour Milling Co., Ltd. | Anti-krebs-wirkstoff |
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-
1999
- 1999-09-23 NZ NZ510732A patent/NZ510732A/en unknown
- 1999-09-23 JP JP2000573733A patent/JP2002526446A/ja active Pending
- 1999-09-23 CN CNB998128295A patent/CN1195513C/zh not_active Expired - Fee Related
- 1999-09-23 IL IL14208299A patent/IL142082A/en not_active IP Right Cessation
- 1999-09-23 DK DK99948352.2T patent/DK1115398T3/da active
- 1999-09-23 DE DE69942342T patent/DE69942342D1/de not_active Expired - Lifetime
- 1999-09-23 EP EP99948352A patent/EP1115398B1/de not_active Expired - Lifetime
- 1999-09-23 CA CA2345079A patent/CA2345079C/en not_active Expired - Fee Related
- 1999-09-23 KR KR1020017003703A patent/KR100712383B1/ko not_active IP Right Cessation
- 1999-09-23 RU RU2001111019/04A patent/RU2232758C2/ru not_active IP Right Cessation
- 1999-09-23 CN CNB2005100038550A patent/CN1318413C/zh not_active Expired - Fee Related
- 1999-09-23 WO PCT/US1999/021778 patent/WO2000016772A1/en active IP Right Grant
- 1999-09-23 AT AT99948352T patent/ATE466850T1/de not_active IP Right Cessation
- 1999-09-23 AU AU61553/99A patent/AU757013B2/en not_active Ceased
- 1999-09-23 US US09/404,001 patent/US6417223B1/en not_active Expired - Lifetime
- 1999-11-17 TW TW088120073A patent/TW592695B/zh not_active IP Right Cessation
-
2001
- 2001-03-13 ZA ZA200102057A patent/ZA200102057B/xx unknown
-
2002
- 2002-04-12 US US10/122,019 patent/US6645998B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
TW592695B (en) | 2004-06-21 |
CN1318413C (zh) | 2007-05-30 |
ZA200102057B (en) | 2002-03-19 |
EP1115398A1 (de) | 2001-07-18 |
CA2345079C (en) | 2011-06-21 |
EP1115398B1 (de) | 2010-05-05 |
CN1706838A (zh) | 2005-12-14 |
EP1115398A4 (de) | 2002-10-16 |
RU2232758C2 (ru) | 2004-07-20 |
WO2000016772A1 (en) | 2000-03-30 |
IL142082A0 (en) | 2002-03-10 |
KR100712383B1 (ko) | 2007-05-02 |
US6645998B2 (en) | 2003-11-11 |
JP2002526446A (ja) | 2002-08-20 |
US6417223B1 (en) | 2002-07-09 |
CN1325303A (zh) | 2001-12-05 |
CA2345079A1 (en) | 2000-03-30 |
AU757013B2 (en) | 2003-01-30 |
NZ510732A (en) | 2004-01-30 |
DK1115398T3 (da) | 2010-08-16 |
ATE466850T1 (de) | 2010-05-15 |
CN1195513C (zh) | 2005-04-06 |
US20020156024A1 (en) | 2002-10-24 |
KR20010075306A (ko) | 2001-08-09 |
AU6155399A (en) | 2000-04-10 |
IL142082A (en) | 2005-12-18 |
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