DE852011T1 - Für natives prp-sc spezifische antikörper - Google Patents

Für natives prp-sc spezifische antikörper

Info

Publication number
DE852011T1
DE852011T1 DE0852011T DE96931599T DE852011T1 DE 852011 T1 DE852011 T1 DE 852011T1 DE 0852011 T DE0852011 T DE 0852011T DE 96931599 T DE96931599 T DE 96931599T DE 852011 T1 DE852011 T1 DE 852011T1
Authority
DE
Germany
Prior art keywords
prp
antibody
source
phage
bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0852011T
Other languages
English (en)
Inventor
Stanley Prusiner
R Williamson
Dennis Burton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Scripps Research Institute
Original Assignee
University of California
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24104278&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE852011(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California, Scripps Research Institute filed Critical University of California
Publication of DE852011T1 publication Critical patent/DE852011T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE0852011T 1995-09-14 1996-09-13 Für natives prp-sc spezifische antikörper Pending DE852011T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52810495A 1995-09-14 1995-09-14
PCT/US1996/014840 WO1997010505A1 (en) 1995-09-14 1996-09-13 ANTIBODIES SPECIFIC FOR NATIVE PrP?Sc¿

Publications (1)

Publication Number Publication Date
DE852011T1 true DE852011T1 (de) 2001-10-11

Family

ID=24104278

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69632056T Revoked DE69632056T2 (de) 1995-09-14 1996-09-13 Für natives prp-sc spezifische antikörper
DE0852011T Pending DE852011T1 (de) 1995-09-14 1996-09-13 Für natives prp-sc spezifische antikörper

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69632056T Revoked DE69632056T2 (de) 1995-09-14 1996-09-13 Für natives prp-sc spezifische antikörper

Country Status (12)

Country Link
US (6) US5846533A (de)
EP (2) EP0852011B1 (de)
JP (3) JP3495738B2 (de)
AT (1) ATE263374T1 (de)
AU (1) AU707484B2 (de)
BR (1) BR9610580A (de)
CA (1) CA2231409C (de)
DE (2) DE69632056T2 (de)
ES (1) ES2218598T3 (de)
MX (1) MX9802019A (de)
NZ (1) NZ318689A (de)
WO (1) WO1997010505A1 (de)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3495738B2 (ja) * 1995-09-14 2004-02-09 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア 天然ＰｒＰｓｃ特異的抗体
AU713529B2 (en) * 1996-04-03 1999-12-02 Stichting Dienst Landbouwkundig Onderzoek Method for the detection of prion diseases
EP0934531B1 (de) * 1996-10-15 2004-08-04 D-Gen Limited Diagnose spongiformer encephalopathie
GB2319607A (en) * 1996-11-23 1998-05-27 Electrophoretics International Detection of prion proteins in mononuclear cells
PT909388E (pt) * 1997-02-06 2004-01-30 Enfer Technology Ltd Ensaios imunologicos para encefalopatias espongiformes
US6221614B1 (en) * 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US20060008494A1 (en) * 1997-02-21 2006-01-12 The Regents Of The University Of California Complete inactivation of infectious proteins
US6720355B2 (en) * 1997-02-21 2004-04-13 The Regents Of The University Of California Sodium dodecyl sulfate compositions for inactivating prions
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
EP0861900A1 (de) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunologischer Nachweis von Prionen
US6719988B2 (en) 1997-02-21 2004-04-13 The Regents Of The University Of California Antiseptic compositions for inactivating prions
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
TW585921B (en) * 1997-07-10 2004-05-01 Res Dev Foundation Species specific monoclonal antibodies and phage displayed Fab and scFV fragments for fragments for targeted destruction of imported fire ants
ATE223058T1 (de) 1997-09-19 2002-09-15 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US6923964B1 (en) * 1997-12-02 2005-08-02 Neuralab Limited Active immunization of AScr for prion disorders
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
US6761888B1 (en) * 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US7179892B2 (en) * 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
ATE420355T1 (de) * 1997-12-16 2009-01-15 Univ Zuerich Diagnostik für übertragbare spongiforme enzephalopathie
US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US6528269B1 (en) * 1998-06-22 2003-03-04 Case Western Reserve University Immunological agents specific for prion protein (PRP)
GB2362385B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Non-aggregated ß-forms of prion proteins
GB2371049B (en) * 1998-11-04 2003-06-04 Imp College Innovations Ltd Methods of making antibodies against ß-forms of prion proteins and their uses
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
FI982480A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nisäkkäiden tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
FI982481A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nautaeläinten tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
JP5122705B2 (ja) * 1999-01-25 2013-01-16 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患における異常型タンパク質凝集の迅速かつ高感度の検出
GB9902659D0 (en) * 1999-02-05 1999-03-31 Microbiological Res Authority Assay with reduced background
EP1151305A1 (de) 1999-02-11 2001-11-07 Stichting Dienst Landbouwkundig Onderzoek Prion test
GB2346971B (en) * 1999-02-19 2004-07-21 Audrey Ann Coop Blood test for infectious prion protein using antibodies raised to eye lens crystallin proteins
US6605445B1 (en) * 1999-02-22 2003-08-12 Bayer Corporation Rapid method of determining clearance of prion protein
US6166187A (en) * 1999-03-05 2000-12-26 The Regents Of The University Of California Method of concentrating prion proteins in blood samples
DE19918141A1 (de) * 1999-04-21 2000-10-26 Boehringer Ingelheim Vetmed Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
DE19925073C2 (de) * 1999-06-01 2001-07-19 Stefan Weiss Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung
JP2003521477A (ja) * 1999-06-23 2003-07-15 カプリオン ファーマシューティカルズ インコーポレーティッド プリオン蛋白質ペプチドおよびその使用
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
US6261790B1 (en) * 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
US20040013647A1 (en) * 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
EP1180938B1 (de) * 1999-09-03 2010-03-24 Ramot University Authority For Applied Research & Industrial Development Ltd. Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
WO2001019867A1 (de) * 1999-09-14 2001-03-22 Memorec Stoffel Gmbh Prionen-verwandtes protein
EP1216258A1 (de) * 1999-09-28 2002-06-26 Universität Zürich Faktoren mit prionen bindender aktivität im serum und plasma sowie mittel zur bestimmung von übertragbaren spongiformen encephalopathien
US6437102B1 (en) 1999-11-24 2002-08-20 Bayer Corporation Method of separating prions from biological materials
US7098317B1 (en) * 2000-05-23 2006-08-29 Blood Transfusion Center Of Slovenia Antibodies capable to selectively detect prion PrPSc isoforms
EP1158003B2 (de) * 2000-05-23 2012-12-26 Blood Transfusion Centre of Slovenia Antikörper zum selektiven Nachweis von Prion PrP Sc Isoformen
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20050130320A1 (en) * 2000-11-09 2005-06-16 George Shaji. T. Method for identifying the proteome of cells using an antibody library microarray
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
DE10061200A1 (de) * 2000-12-08 2002-06-27 Niels Wedemeyer Verfahren und Kit zur Diagnose spongiformer Encephalopathien
WO2002046236A1 (fr) * 2000-12-08 2002-06-13 Fujirebio Inc. Anticorps monoclonal dirigé contre un prion anormal, procédé de production correspondant, et procédé d'essai immunologique l'utilisant
US20020194635A1 (en) * 2001-03-30 2002-12-19 Dunne Patrick W. Transgenic animals resistant to transmissible spongiform encephalopathies
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien
CA2448981C (en) * 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
GB0125606D0 (en) * 2001-10-25 2001-12-19 Sec Dep For Environment Food & Diagnostic method
RU2309410C2 (ru) * 2002-02-28 2007-10-27 Майкроусенс Байофейдж Лимитед Связывание патологических форм прионовых белков
US8658374B2 (en) 2002-02-28 2014-02-25 Microsens Biphage Limited Binding of aggregated forms of proteins
BR0200690A (pt) * 2002-03-04 2004-03-23 Embrapa Pesquisa Agropecuaria Método para detecção de proteinas de origem em misturas complexas
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
NZ536054A (en) * 2002-04-09 2009-10-30 Scripps Research Inst Motif-grafted hybrid polypeptides and uses thereof
EP1534746A2 (de) * 2002-08-23 2005-06-01 Copenhagen Biotech Assets APS Mischpeptide zum nachweis und behandlung der von prion-proteinen verursachten krankheiten
AU2003272491B2 (en) * 2002-09-18 2008-10-02 The Trustees Of The University Of Pennsylvania Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
US20040067496A1 (en) * 2002-10-07 2004-04-08 Robert Pytela System for production and screening of monoclonal antibodies
DE03799419T1 (de) * 2002-10-10 2005-04-07 The Regents Of The University Of California, Oakland Verwendung monoklonaler antikörper zur unterscheidung von proteinkonformationsisoformen
US20040175775A1 (en) * 2002-11-08 2004-09-09 Neil Cashman Method of detecting PrPsc in eye fluid
GB0227886D0 (en) * 2002-11-29 2003-01-08 Medical Res Council Prion inhibition
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2005019412A2 (en) 2003-05-20 2005-03-03 New York University Mucosal immunization to prevent prion infection
US8685718B2 (en) * 2003-05-20 2014-04-01 New York University Mucosal immunization to prevent prion infection
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) * 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
WO2005034995A1 (en) * 2003-09-10 2005-04-21 Chiron Corporation Prion chimeras and uses thereof
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
WO2005111609A2 (en) * 2004-04-19 2005-11-24 Department Of Veterans Affairs Methods for rapid screening of mad cow disease and other transmissible spongiform encephalopathies
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4644680B2 (ja) * 2004-10-15 2011-03-02 積水化学工業株式会社 動物の免疫方法、免疫用組成物、抗体の製造方法、ハイブリドーマの製造方法、及びモノクローナル抗体の製造方法
WO2006046344A1 (ja) * 2004-10-29 2006-05-04 Kagoshima University ヒト抗プリオン抗体及び該抗体フラグメント
TW200636066A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized antibodies that recognize beta amyloid peptide
PE20061401A1 (es) * 2004-12-15 2006-12-23 Neuralab Ltd ANTICUERPOS Aß PARA MEJORAR LA COGNICION
US20080254486A1 (en) * 2004-12-15 2008-10-16 University Of Guelph Prion Sensors for Diagnosis of Transmissible Spongiform Encephalopathy or for Detection of Prions, and Use Thereof
TW200635607A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized Aβ antibodies for use in improving cognition
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
MX2007008497A (es) * 2005-01-13 2007-09-14 Novartis Vaccines & Diagnostic Ensayos inmunosorbentes enlazados a enzimas usando reactivos de peptidos especificos de prion.
US20090099343A1 (en) * 2005-01-13 2009-04-16 David Peretz Isolation of pathogenic prions
US8372593B2 (en) 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
WO2006105622A1 (fr) * 2005-04-04 2006-10-12 Universite De Liege Nouveaux supports, en particulier pour 1 ' immunodetection molecules d'interet
US20090209867A1 (en) * 2005-04-18 2009-08-20 Cha Min Tang Method for rapid screening of mad cow disease and other transmissible spongiform encephalopathies
EP1931695B1 (de) * 2005-09-09 2013-04-10 Novartis AG Prionspezifische Peptoidreagentien
KR101439828B1 (ko) 2005-11-30 2014-09-17 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
AU2006319358B2 (en) 2005-11-30 2012-01-19 AbbVie Deutschland GmbH & Co. KG Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
US8876753B2 (en) 2006-01-30 2014-11-04 The Regents Of The University Of California Peritoneal dialysis methods and apparatus
US8187250B2 (en) * 2006-01-30 2012-05-29 The Regents Of The University Of California Peritoneal dialysis methods and apparatus
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
KR101605207B1 (ko) 2006-07-14 2016-03-22 에이씨 이뮨 에스.에이. 아밀로이드 베타에 대해 인간화된 항체
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20080131500A1 (en) * 2006-12-04 2008-06-05 The Board Of Regents Of The University Of Texas System Methods and compositions for rapid inactivation of proteins
WO2008104386A2 (en) 2007-02-27 2008-09-04 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
RU2523894C2 (ru) * 2007-04-18 2014-07-27 Янссен Альцгеймер Иммунотерапи Предупреждение и лечение церебральной амилоидной ангиопатии
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
BRPI0812484A2 (pt) * 2007-06-12 2018-06-05 Ac Immune Sa anticorpo monoclonal, regiões variáveis de cadeia leve e de cadeia pesada, cdr isolada, polinucleotídeo, composição terapêutica, métodos para tratar doenças e distúrbios, para produzir um anticorpo, para tratar ou aliviar os efeitos de doenças e distúrbios, para reduzir a carga de placas no cérebro de um indivíduo, para reduzir a quantidade de placas no cérebro de um indivíduo, para diminuir a quantidade total de abeta solúvel no cérebro de um indivíduo, para reter ou aumentar a capacidade de memória cognitiva em um indivíduo, de diagnose de ou para diagnosticar uma predisposição para uma doença associada com amilóide ou condição em um paciente, para determinar a extensão de carga de placa amiloidogênica em um tecido de um indivíduo, para monitorar doença residual mínima em um indivíduo e para prever responsividade de um indivíduo, linhagem de células, kit de teste, epítopo abeta
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
DK2182983T3 (da) 2007-07-27 2014-07-14 Janssen Alzheimer Immunotherap Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
EP2238166B1 (de) 2007-10-05 2013-11-27 Genentech, Inc. Verwendung eines anti-amyloid-beta-antikörpers bei augenkrankheiten
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
BRPI0910550A2 (pt) * 2008-04-30 2015-09-29 Novartis Ag ensaio para confôrmeros patogênicos
CA2735020A1 (en) * 2008-08-29 2010-03-04 Symphogen A/S Method for cloning avian-derived antibodies
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
US9079942B2 (en) 2009-02-09 2015-07-14 Epitomics, Inc. CDR-anchored amplification method
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
KR101149402B1 (ko) * 2009-07-23 2012-06-27 대한민국 소해면상뇌증의 변형프리온을 감별 및 검출할 수 있는 단클론항체, 이를 생산하는 융합세포주 및 그 용도
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
CA2796339C (en) 2010-04-15 2020-03-31 Abbott Laboratories Amyloid-beta binding proteins
SG187173A1 (en) 2010-07-30 2013-02-28 Ac Immune Sa Safe and functional humanized anti beta-amyloid antibody
EP3533803B1 (de) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antikörper
WO2013009767A2 (en) 2011-07-12 2013-01-17 Epitomics, Inc. Facs-based method for obtaining an antibody sequence

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4806627A (en) * 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
SG47979A1 (en) * 1991-11-14 1998-04-17 Charles Weissman Transgenic animals lacking prion proteins
WO1993023432A1 (en) * 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
JP3495738B2 (ja) * 1995-09-14 2004-02-09 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア 天然ＰｒＰｓｃ特異的抗体
US6528269B1 (en) 1998-06-22 2003-03-04 Case Western Reserve University Immunological agents specific for prion protein (PRP)
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US6261790B1 (en) 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
AU780414B2 (en) 1999-07-27 2005-03-17 D-Gen Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases

Also Published As

Publication number Publication date
US20050158803A1 (en) 2005-07-21
EP0852011A1 (de) 1998-07-08
DE69632056D1 (de) 2004-05-06
JP3586273B2 (ja) 2004-11-10
US7052675B2 (en) 2006-05-30
US6562341B2 (en) 2003-05-13
US6290954B1 (en) 2001-09-18
ATE263374T1 (de) 2004-04-15
WO1997010505A1 (en) 1997-03-20
US5846533A (en) 1998-12-08
JP2004002396A (ja) 2004-01-08
US6858397B2 (en) 2005-02-22
JP2000500005A (ja) 2000-01-11
AU707484B2 (en) 1999-07-08
EP0852011A4 (de) 2001-04-18
MX9802019A (es) 1998-10-31
BR9610580A (pt) 2000-10-24
JP3586275B2 (ja) 2004-11-10
NZ318689A (en) 1999-02-25
JP3495738B2 (ja) 2004-02-09
EP1416280A2 (de) 2004-05-06
JP2004002439A (ja) 2004-01-08
CA2231409A1 (en) 1997-03-20
CA2231409C (en) 2003-02-11
US20030228303A1 (en) 2003-12-11
DE69632056T2 (de) 2004-12-30
US20020150571A1 (en) 2002-10-17
ES2218598T3 (es) 2004-11-16
EP0852011B1 (de) 2004-03-31
US6372214B1 (en) 2002-04-16
AU7073596A (en) 1997-04-01
EP1416280A3 (de) 2005-08-10

Similar Documents

Publication Publication Date Title
DE69632056D1 (de) Für natives prp-sc spezifische antikörper
Revak et al. The relationship of structure and function in human Hageman factor. The association of enzymatic and binding activities with separate regions of the molecule.
DK0930366T3 (da) Bindingsdomæner i Delta-proteiner
DE60231651D1 (de) Proteinreinigungsverfahren
DK0593618T3 (da) Screeningsassay til påvisning af DNA-bindende molekyler
ATE409862T1 (de) Verfahren zur analytbestimmung unter verwendung eines universellen analysenelementes
DE69626027T2 (de) Verfahren zur elimination der interferenz des rheumatoiden faktors in diagnostischen tests
KR900700170A (ko) 파라로그 어피니티 크로마토그라피
ATE441111T1 (de) Metallchelat-markierte peptide
ATE133264T1 (de) Immunologisches nachweisverfahren
DE3650437T2 (de) Verfahren zum Messen von Freiliganden in biologischen Flüssigkeiten.
ATE188551T1 (de) Feststellung von antikörperproduktion
DE59906849D1 (de) Verfahren zum spezifischen Nachweis von glykosilierten Proteinen
DE3853282T2 (de) Diagnostischer Test für Pseudomonas Aeruginosa Infektionen.