EP0000983A1 - Programmably variable voltage multiplier for implantable stimulator - Google Patents
Programmably variable voltage multiplier for implantable stimulator Download PDFInfo
- Publication number
- EP0000983A1 EP0000983A1 EP78300236A EP78300236A EP0000983A1 EP 0000983 A1 EP0000983 A1 EP 0000983A1 EP 78300236 A EP78300236 A EP 78300236A EP 78300236 A EP78300236 A EP 78300236A EP 0000983 A1 EP0000983 A1 EP 0000983A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- capacitor
- output
- oscillator
- pacer
- control signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
- H02M3/00—Conversion of dc power input into dc power output
- H02M3/02—Conversion of dc power input into dc power output without intermediate conversion into ac
- H02M3/04—Conversion of dc power input into dc power output without intermediate conversion into ac by static converters
- H02M3/06—Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using resistors or capacitors, e.g. potential divider
- H02M3/07—Conversion of dc power input into dc power output without intermediate conversion into ac by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode, e.g. charge pumps
Definitions
- This invention relates to implantable body function ctonrol apparatus and particularly, but not exclusively, to body tissue stimulating devices such as cardiac pacemakers.
- Pacemakers for generating artificial stimulating pulses for the heart, and which may be implanted in the body, are well known.
- the electrical circuitry for such pacemakers was of analog design, but in recent years digital circuitry has been also employed.
- a digital approach to pacemakers has led to the evolution of programmable pacemekers - pacemakers having parameters such as pulse rates which. are adjustable (programmable) once the pacemaker has been implanted.
- Programmable pacemakers are described in, for instance, British Specifications 1,385,954 and 1,398,875.
- Such pacemakers have circuitry to detect and decode signals transmitted outside the body and alter the program accordingly.
- British Specification 1,385,954 (claiming priority based on U.S.S.N. 141,694, in turn a parent of U.S.P.N.
- the programming is accomplished by means of a magnetic field which is sensed by a magnetic reed switch; the opening and closing of the switch providing programming pulses to a program store.
- a magnetic reed switch the opening and closing of the switch providing programming pulses to a program store.
- the programming is by means of radio frequency transmission and reception.
- a body function control apparatus comprising an oscillator, means responsive to the oscillator for generating tissue stimulating pulse control signals, an output stage responsive to signals from the control signal generating means for providing tissue stimulating pulses to the body, a voltage source for said apparatus, voltage multiplication means responsive to said oscillator and said voltage source for generating one or more voltages of magnitude higher than that supplied by said voltage source and for supplying said higher voltage (s) to said output stage whereby tissue stimulating pulses of voltage magnitude higher than that supplied by said voltage source are provided.
- the pacemaker comprises an oscillator 2 which drives a ripple counter 4.
- An output of the ripple counter (which may actually be the combination of several stages of the counter) supplies an output line 6.
- the oscillator frequency and the ripple counter output selected provided signals on line 6 at an appropriate body stimulation pulse frequency.
- Line 6 is connected to an output amplifier (within the block formed by the dashed line 14), from whence amplified stimulating pulses are passed to a connection 16 which itself is connected to the active stimulating electrode (not shown) disposed in or on the heart,
- Line 6 is also connected to a delay unit 18 which, after an appropriate time, resets the counter 4, to enable the next appropriately timed pulse to be transmitted.
- the output amplifier 14 includes an output transistor 26, across which is connected a capacitor 28. One end of the latter is connected to the rail V DD of the supply voltage. The other end of capacitor 28 and the emitter of transistor 26 are connected to a chain of Schottky diodes 30, 32, 34, and 36 (Schottky diodes are chosen for their low voltage drop wh.en forward-biased).
- the cathode of diode 32 is connected to the rail V SS of the supply voltage.
- the supply voltage V SS -V DD is about 3 volts.
- the output of oscillator 2 is supplied to an inverter 38 and via a NAND gate 40 to a second inverter 42. The inverters feed, respectively, capacitors 44 and 46 which lead into the diode chain as illustrated.
- NAND gate 40 is supplied with a further input, which is from a control line 22 from a pacemaker program store 20.
- the pacemaker program store 20 holds a binary bit of information which is transmitted on line 22 for voltage multiplication purposes as to be described.
- a receiver/decoder 24 is arranged to receive and decode data signals transmitted from outside the patient's body to the implanted pacemaker, and to employ the decoded signals for changing the pacemaker program held in program store 20.
- the receiver/decoder 24 and store 20 have been depicted very simply and as providing an output for selecting only the stimulating pulse amplitude. In practice it would be desirable to make these features much more sophisticated so that the program store is employed to provide a varying control for several different pacemaker parameters (e.g. not only pulse amplitude, but also pulse rate, pulse width, hysteresis).
- the data signals may be transmitted to the receiver/decoder 24 by any suitable means, but preferably we employ data signals transmitted by tone burst modulation (a carrier frequency being pulse width modulated).
- tone burst modulation a carrier frequency being pulse width modulated.
- a receiver/decoder and program store for such data signals is described in copending Application No. filed on even date (ref. DLD-10. ).
- pacemaker components described are constructed as a MOS integrated circuit, and this has been indicated by the block formed by the dashed line 50.
- the integrated circuit is supplied as is customary, with V DD and V SS , but it will be observed that the output transistor 26 of amplifier 14 is connected across V DD and V ss in series with the diode chain.and with capacitor 28 in parallel.
- the pacemaker operates as follows. Each pulse on output line 6 at the selected rate is passed to output amplifier 14 where it is amplified and conducted to the heart; it is also conducted to delay unit 18. After an appropriate delay corresponding to the pacing pulse width desired, delay unit 18 resets counter 4 and the count then commences in counter 4 for the next appropriately timed pulse to be issued.
- V DD is essentially the circuit ground by reason of being connected to the pacemaker indifferent electrode and V SS is supplied at about 3 volts.
- This 3 volt supply is sufficient for the integrated circuit 50, but insufficient for the output amplifier 14, which in conventional practice needs to generate stimulating pulses of at least about 5 volts for satisfactory pacing. It will be assumed that normally about 5 volts is desired for each pacing pulss but that, under certain circumstances, larger pacing pulses (or about 7.5 volts) are required. The manner in which the approximately 5 volt pulses are generated will first be described, and then the manner in which the 7.5 volt pulses are generated.
- capacitor 28 When V D goes to its most positive due to the square wave pulse train supplied by oscillator 2, a 3 volt drop will exist across capacitor 44 and the latter will charge via diode 32. When V goes negative due to the oscillator pulse train, point X goes further negative. At this time diode 30 is forward-biased and it conducts, causing capacitor 28 to acquire an amount of charge due to the sharing of charge between capacitors 44 and 28..Taking into account diode voltage drops and assuming that no current is being drawn from the output amplifier circuit (no pacing pulse being issued), capacitor 28 will charge to about 5 volts over several cycles of the oscillator pulse train and it will hold its charge until a pacing pulse is transmitted to the output amplifier 14 from the integrated circuit 50.
- capacitor 28 With no current being drawn from the output transistor 26, and hence no potential drop across its collector resistor, the 5 volt potential held by capacitor 28 appears directly across output transistor 26 and hence the amplitude of the pacing pulse transmitted to the active electrode at connection 16, when this transistor is switched on, is at about 5 volts rather than the 3 volts supplied by V DD /V SS . It will be appreciated that capacitor 28 will charge to 5 volts gradually over several cycles of the oscillator frequency, but provided that the latter frequency is much higher than the stimulating pulse frequency, capacitor 28 will always be charged to 5 volts ready for discharge on the next pacing pulse.
- V T will be positive charging capacitor 46 (about about -5 volts)
- V D goes positive
- V T will go negative and capacitor 46 will share its charge with capacitor 28.
- the effect is for capacitor 28 to charge to a higher voltage than it would have done if charged only from capacitor 44.
- capacitor 28 will charge, over several cycles of the oscillator pulse train, to a potential difference of about 7.5 volts.
- a pacing pulse is transmitted to the output amplifier 14, this 7.5 volts is employed to provide a pacing pulse to connection 16 of corresponding magnitude.
Abstract
Description
- This invention relates to implantable body function ctonrol apparatus and particularly, but not exclusively, to body tissue stimulating devices such as cardiac pacemakers.
- Pacemakers for generating artificial stimulating pulses for the heart, and which may be implanted in the body, are well known. Originally the electrical circuitry for such pacemakers was of analog design, but in recent years digital circuitry has been also employed. A digital approach to pacemakers has led to the evolution of programmable pacemekers - pacemakers having parameters such as pulse rates which. are adjustable (programmable) once the pacemaker has been implanted. Programmable pacemakers are described in, for instance, British Specifications 1,385,954 and 1,398,875. Such pacemakers have circuitry to detect and decode signals transmitted outside the body and alter the program accordingly. In British Specification 1,385,954 (claiming priority based on U.S.S.N. 141,694, in turn a parent of U.S.P.N. 3,805,796 to Tenz), the programming is accomplished by means of a magnetic field which is sensed by a magnetic reed switch; the opening and closing of the switch providing programming pulses to a program store.. In British Specification 1,398,875 (based on U.S.P.N. 3,833,005 to Wingrove) the programming is by means of radio frequency transmission and reception.
- It is desirable to miniaturize pacemaker components as far as possible, especially where implanted pac=-=kers are concerned, and although integrated circuit techniques can help enormously to achieve this aim, the battery size is still a major problem. The moat recently-available miniature batteries having sufficient power and life for pacemaker usage are lithium batteries (both of the "solid" and "viscous" types), and such batteries are now employed in pacemakers. Unfortunately, lithium batteries only generate about 3 volts and although this voltage is sufficient to provide the supply voltage for, say, an integrated circuit pacemaker, it is insufficient, in itself, for the pacemaker output stage which needs to generate artificial stimulating pulses of at least 5 volts. Under certain circumstances, it is even desirable to generate pacing pulses of greater magnitude (e.g. about 7,5 volts). Although two or more lithium batteries can be employed for such purposes (and, indeed, have in the past been so employed), this militates against the desire for maximum miniaturization.
- We have now designed an implantable body function control apparatus which employs a single relatively low voltage source, but which generates, by means of voltage multiplication, the higher voltages for the pacing pulses issued.
- According to the invention, there is provided a body function control apparatus comprising an oscillator, means responsive to the oscillator for generating tissue stimulating pulse control signals, an output stage responsive to signals from the control signal generating means for providing tissue stimulating pulses to the body, a voltage source for said apparatus, voltage multiplication means responsive to said oscillator and said voltage source for generating one or more voltages of magnitude higher than that supplied by said voltage source and for supplying said higher voltage (s) to said output stage whereby tissue stimulating pulses of voltage magnitude higher than that supplied by said voltage source are provided.
- Although this invention is of especial use for cardiac pacemakers, it is not restricted tc such use and could =e employed for controlling other body functions.
- Breferred features of the invsntion are illustrated with reference to the accompanying drawing, which schematically illustrates an electrical circuit diagram of a programmable fixed-rate implanted cardiac pacemaker according to the invention.
- Referring to the drawing, the pacemaker comprises an oscillator 2 which drives a ripple counter 4. An output of the ripple counter (which may actually be the combination of several stages of the counter) supplies an
output line 6. The oscillator frequency and the ripple counter output selected provided signals online 6 at an appropriate body stimulation pulse frequency.Line 6 is connected to an output amplifier (within the block formed by the dashed line 14), from whence amplified stimulating pulses are passed to a connection 16 which itself is connected to the active stimulating electrode (not shown) disposed in or on the heart,Line 6 is also connected to adelay unit 18 which, after an appropriate time, resets the counter 4, to enable the next appropriately timed pulse to be transmitted. - The output amplifier 14 includes an
output transistor 26, across which is connected acapacitor 28. One end of the latter is connected to the rail VDD of the supply voltage. The other end ofcapacitor 28 and the emitter oftransistor 26 are connected to a chain of Schottkydiodes diode 32 is connected to the rail VSS of the supply voltage. For the purposes of illustration, the supply voltage VSS-VDD is about 3 volts. The output of oscillator 2 is supplied to aninverter 38 and via aNAND gate 40 to asecond inverter 42. The inverters feed, respectively,capacitors 44 and 46 which lead into the diode chain as illustrated. NANDgate 40 is supplied with a further input, which is from acontrol line 22 from apacemaker program store 20. - The
pacemaker program store 20 holds a binary bit of information which is transmitted online 22 for voltage multiplication purposes as to be described. A receiver/decoder 24 is arranged to receive and decode data signals transmitted from outside the patient's body to the implanted pacemaker, and to employ the decoded signals for changing the pacemaker program held inprogram store 20. For the purposes of illustration, the receiver/decoder 24 andstore 20 have been depicted very simply and as providing an output for selecting only the stimulating pulse amplitude. In practice it would be desirable to make these features much more sophisticated so that the program store is employed to provide a varying control for several different pacemaker parameters (e.g. not only pulse amplitude, but also pulse rate, pulse width, hysteresis). The data signals may be transmitted to the receiver/decoder 24 by any suitable means, but preferably we employ data signals transmitted by tone burst modulation (a carrier frequency being pulse width modulated). A receiver/decoder and program store for such data signals is described in copending Application No. filed on even date (ref. DLD-10. ). - Many of the pacemaker components described are constructed as a MOS integrated circuit, and this has been indicated by the block formed by the dashed line 50. The integrated circuit is supplied as is customary, with VDD and VSS, but it will be observed that the
output transistor 26 of amplifier 14 is connected across VDD and Vss in series with the diode chain.and withcapacitor 28 in parallel. - The pacemaker operates as follows. Each pulse on
output line 6 at the selected rate is passed to output amplifier 14 where it is amplified and conducted to the heart; it is also conducted to delayunit 18. After an appropriate delay corresponding to the pacing pulse width desired,delay unit 18 resets counter 4 and the count then commences in counter 4 for the next appropriately timed pulse to be issued. - In normal operation VDD is essentially the circuit ground by reason of being connected to the pacemaker indifferent electrode and VSS is supplied at about 3 volts. This 3 volt supply is sufficient for the integrated circuit 50, but insufficient for the output amplifier 14, which in conventional practice needs to generate stimulating pulses of at least about 5 volts for satisfactory pacing. It will be assumed that normally about 5 volts is desired for each pacing pulss but that, under certain circumstances, larger pacing pulses (or about 7.5 volts) are required. The manner in which the approximately 5 volt pulses are generated will first be described, and then the manner in which the 7.5 volt pulses are generated.
- For 5 volt stimulating pulses, a "0" is held in
program store 20 and is supplied online 22 to NANDgate 40. The output ofNAND gate 40 will be high and point VT (betweeninverter 42 and capacitor 46) will always be low. VT will therefore not manifest the oscillator square wave output, On the other hand, point V (betweeninverter 38 and capacitor 44) will manifest the square wave output of oscillator 2. Point "X", at the junction ofdiodes diode 32, normally be held at VSS(-3 volts).Capacitor 28 charges to -30 volts viadiodes diode 32. When V goes negative due to the oscillator pulse train, point X goes further negative. At thistime diode 30 is forward-biased and it conducts, causingcapacitor 28 to acquire an amount of charge due to the sharing of charge betweencapacitors 44 and 28..Taking into account diode voltage drops and assuming that no current is being drawn from the output amplifier circuit (no pacing pulse being issued),capacitor 28 will charge to about 5 volts over several cycles of the oscillator pulse train and it will hold its charge until a pacing pulse is transmitted to the output amplifier 14 from the integrated circuit 50. With no current being drawn from theoutput transistor 26, and hence no potential drop across its collector resistor, the 5 volt potential held bycapacitor 28 appears directly acrossoutput transistor 26 and hence the amplitude of the pacing pulse transmitted to the active electrode at connection 16, when this transistor is switched on, is at about 5 volts rather than the 3 volts supplied by VDD/VSS. It will be appreciated thatcapacitor 28 will charge to 5 volts gradually over several cycles of the oscillator frequency, but provided that the latter frequency is much higher than the stimulating pulse frequency,capacitor 28 will always be charged to 5 volts ready for discharge on the next pacing pulse. - When pacing pulses of about 7 volts magnitude are desired, a "1" is held in program store 2Q and is supplied on
line 22 to NANDgate 40. The output downstream of inverter 42 (at VT) is the oscillator square wave pulse train but in anti-phase to the similar pulse train at VD. - Under such circumstances, when V goes negative, point X goes further negative, as previously explained, and VT will be positive charging capacitor 46 (about about -5 volts), When VD goes positive, VT will go negative and
capacitor 46 will share its charge withcapacitor 28. The effect is forcapacitor 28 to charge to a higher voltage than it would have done if charged only from capacitor 44. Taking into account diode drops, and assuming that no current is drawn fromoutput transistor 26,capacitor 28 will charge, over several cycles of the oscillator pulse train, to a potential difference of about 7.5 volts. When a pacing pulse is transmitted to the output amplifier 14, this 7.5 volts is employed to provide a pacing pulse to connection 16 of corresponding magnitude. - It will thus be appreciated that the presence of a "0" or "1" on
line 22 controls the magnitude of the pacing pulses. - Although the above embodiment relates to a fixed-rate cardiac pacemaker, it will be appreciated that this is only given for the purposes of example, and the invention is equally-applicable to demand cardiac pacemakers, or to body function control apparatus employed to provide stimulating pulses of varying amplitude to other parts of the body,
Claims (3)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3491677 | 1977-08-19 | ||
GB3491677 | 1977-08-19 | ||
US05/917,140 US4203448A (en) | 1977-08-19 | 1978-06-19 | Programmably variable voltage multiplier for implanted stimulator |
US917140 | 1978-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0000983A1 true EP0000983A1 (en) | 1979-03-07 |
EP0000983B1 EP0000983B1 (en) | 1981-11-18 |
Family
ID=26262492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19780300236 Expired EP0000983B1 (en) | 1977-08-19 | 1978-08-03 | Programmably variable voltage multiplier for implantable stimulator |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0000983B1 (en) |
AU (1) | AU3895678A (en) |
CA (1) | CA1114025A (en) |
DE (1) | DE2861332D1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2440198A1 (en) * | 1978-11-06 | 1980-05-30 | Medtronic Inc | IMPLANTABLE STIMULATOR |
US5876423A (en) * | 1996-06-04 | 1999-03-02 | Biotronik Mess- Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin | Implantable stimulator with terminal voltage control of a depletable voltage source |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH064096B2 (en) * | 1987-03-25 | 1994-01-19 | 株式会社アドバンス | Skin adhesive type low frequency treatment device |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656487A (en) * | 1969-06-12 | 1972-04-18 | Medtronic Inc | Electronic demand heart pacemaker with different pacing and standby rates |
US3707974A (en) * | 1970-12-11 | 1973-01-02 | W Raddi | Body organ stimulator with voltage converter |
US3726285A (en) * | 1971-04-26 | 1973-04-10 | Gen Electric | Body organ stimulus pulse generator with decoupled timing circuit and voltage multiplier |
US3833005A (en) * | 1971-07-26 | 1974-09-03 | Medtronic Inc | Compared count digitally controlled pacemaker |
DE2639554A1 (en) * | 1975-09-04 | 1977-03-17 | Plessey Handel Investment Ag | VOLTAGE MULTIPLE CONNECTION |
US4031899A (en) * | 1976-01-22 | 1977-06-28 | Vitatron Medical B.V. | Long life cardiac pacer with switching power delivery means and method of alternately delivering power to respective circuit portions of a stimulus delivery system |
-
1978
- 1978-08-03 EP EP19780300236 patent/EP0000983B1/en not_active Expired
- 1978-08-03 DE DE7878300236T patent/DE2861332D1/en not_active Expired
- 1978-08-16 AU AU38956/78A patent/AU3895678A/en active Pending
- 1978-08-17 CA CA309,562A patent/CA1114025A/en not_active Expired
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3656487A (en) * | 1969-06-12 | 1972-04-18 | Medtronic Inc | Electronic demand heart pacemaker with different pacing and standby rates |
US3707974A (en) * | 1970-12-11 | 1973-01-02 | W Raddi | Body organ stimulator with voltage converter |
US3726285A (en) * | 1971-04-26 | 1973-04-10 | Gen Electric | Body organ stimulus pulse generator with decoupled timing circuit and voltage multiplier |
US3833005A (en) * | 1971-07-26 | 1974-09-03 | Medtronic Inc | Compared count digitally controlled pacemaker |
DE2639554A1 (en) * | 1975-09-04 | 1977-03-17 | Plessey Handel Investment Ag | VOLTAGE MULTIPLE CONNECTION |
US4031899A (en) * | 1976-01-22 | 1977-06-28 | Vitatron Medical B.V. | Long life cardiac pacer with switching power delivery means and method of alternately delivering power to respective circuit portions of a stimulus delivery system |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2440198A1 (en) * | 1978-11-06 | 1980-05-30 | Medtronic Inc | IMPLANTABLE STIMULATOR |
EP0011934A2 (en) * | 1978-11-06 | 1980-06-11 | Medtronic, Inc. | Body stimulator |
EP0011934A3 (en) * | 1978-11-06 | 1981-01-07 | Medtronic, Inc. | Body stimulator |
US5876423A (en) * | 1996-06-04 | 1999-03-02 | Biotronik Mess- Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin | Implantable stimulator with terminal voltage control of a depletable voltage source |
Also Published As
Publication number | Publication date |
---|---|
AU3895678A (en) | 1980-02-21 |
DE2861332D1 (en) | 1982-01-21 |
CA1114025A (en) | 1981-12-08 |
EP0000983B1 (en) | 1981-11-18 |
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