EP0125555A3 - Unified test means for ion determination - Google Patents

Unified test means for ion determination Download PDF

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Publication number
EP0125555A3
EP0125555A3 EP84104828A EP84104828A EP0125555A3 EP 0125555 A3 EP0125555 A3 EP 0125555A3 EP 84104828 A EP84104828 A EP 84104828A EP 84104828 A EP84104828 A EP 84104828A EP 0125555 A3 EP0125555 A3 EP 0125555A3
Authority
EP
European Patent Office
Prior art keywords
test
test means
ion
unified test
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84104828A
Other versions
EP0125555B1 (en
EP0125555A2 (en
Inventor
Steven C. Charlton
Roger L. Fleming
Arthur L. Y. Lau
Paul Hemmes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23962528&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0125555(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Priority to AT84104828T priority Critical patent/ATE48918T1/en
Publication of EP0125555A2 publication Critical patent/EP0125555A2/en
Publication of EP0125555A3 publication Critical patent/EP0125555A3/en
Application granted granted Critical
Publication of EP0125555B1 publication Critical patent/EP0125555B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Abstract

A test means, test device and method for use for determining the presence of an ion in a test sample are dislosed. The test means comprises a substantially nonpolar, nonporous carrier matrix incorporated with an ionophore capable of forming a complex with the specific ion, and a reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response. The test device comprises an elongated support member having a upper, substantially flat face to which is affixed the test means. The test means and test device are used by contacting either with the test sample, and observing a detectable response.
EP84104828A 1983-05-12 1984-04-30 Unified test means for ion determination Expired EP0125555B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84104828T ATE48918T1 (en) 1983-05-12 1984-04-30 COMPACT TEST EQUIPMENT FOR DETERMINING IONS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49398383A 1983-05-12 1983-05-12
US493983 1983-05-12

Publications (3)

Publication Number Publication Date
EP0125555A2 EP0125555A2 (en) 1984-11-21
EP0125555A3 true EP0125555A3 (en) 1985-10-16
EP0125555B1 EP0125555B1 (en) 1989-12-20

Family

ID=23962528

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84104828A Expired EP0125555B1 (en) 1983-05-12 1984-04-30 Unified test means for ion determination

Country Status (12)

Country Link
US (1) US4645744A (en)
EP (1) EP0125555B1 (en)
JP (1) JPS59211864A (en)
AT (1) ATE48918T1 (en)
AU (1) AU552420B2 (en)
CA (1) CA1222438A (en)
DE (1) DE3480809D1 (en)
DK (1) DK161262C (en)
ES (1) ES532280A0 (en)
FI (1) FI77937C (en)
NO (1) NO162132C (en)
ZA (1) ZA843496B (en)

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Publication number Priority date Publication date Assignee Title
CA1253057A (en) * 1984-02-24 1989-04-25 Mary L. Gantzer Ion test means having a porous carrier matrix
US4734376A (en) * 1985-02-04 1988-03-29 The President & Trustees Of The Miami University Process for the spectrophotometric measurement of lithium ion employing a chromogenic aza-12-crown-4- ether
IL79087A0 (en) 1985-07-02 1986-09-30 Miles Lab Multilayer ion test means
ZA864513B (en) * 1985-07-02 1987-02-25 Miles Lab Multilayer ion test means
US4820647A (en) * 1986-12-03 1989-04-11 Biotrack, Inc. Method for detecting a metal ion in an aqueous environment
JPH0642839B2 (en) * 1987-04-10 1994-06-08 ザ フリンダーズ ユニヴアーシテイ オブ サウス オーストラリア Method for measuring potassium ion in body fluid and composition therefor
US5177221A (en) * 1987-04-15 1993-01-05 Miles Inc. Chromogenic hemispherands and their preparation
US4808539A (en) * 1987-04-15 1989-02-28 Technicon Instruments Corporation Compounds, reagents and procedures for determining cations
US5045475A (en) * 1987-04-15 1991-09-03 Technicon Instruments Corporation Reagent for determining cations
US5073501A (en) * 1987-04-15 1991-12-17 Technicon Instruments Corporation Method for determining the concentration of cations in a sample
US5096831A (en) * 1987-04-15 1992-03-17 Miles Inc. Reagents for determining cations
US4992381A (en) * 1987-04-15 1991-02-12 Technicon Instruments Corporation Method of detecting electrolytes in an aqueous test sample using chromogenic hemispherands and test device therefor
US5162525A (en) * 1987-07-31 1992-11-10 Allied-Signal Inc. Fluorogenic and chromogenic three-dimensional ionophores as selective reagents for detecting ions in biological fluids
US5136033A (en) * 1987-08-24 1992-08-04 Allied-Signal Inc. Ion selective fluorogenic reagents
US5047563A (en) * 1987-09-10 1991-09-10 Miles Inc. Chiral crown ethers
US5133934A (en) * 1987-09-10 1992-07-28 Miles Inc. Ionosphere and reporter substance incorporated into a hydrophobic carrier
US5564419A (en) * 1987-11-25 1996-10-15 Radiometer A/S Method of photometric in vitro determination of the content of oxygen in a blood sample
DK163194C (en) * 1988-12-22 1992-06-22 Radiometer As METHOD OF PHOTOMETRIC IN VITRO DETERMINING A BLOOD GAS PARAMETER IN A BLOOD TEST
IL88278A (en) * 1987-12-11 1993-02-21 Miles Inc Method for the preparation of a homogeneous aqueous test solution for electrolyte test and a homogeneous solution for measuring the concentration of an ion in an aqueous test sample
DE3823151C2 (en) * 1988-07-08 1997-07-10 Boehringer Mannheim Gmbh Method for determining the ionic strength or specific gravity of aqueous liquids
DE4015591A1 (en) * 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh NAPHTHOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
DE4015590A1 (en) * 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh TEST CARRIER FOR THE DETERMINATION OF IONS
CA2047966C (en) * 1990-08-06 2001-10-09 Steven C. Charlton Method and device for the assay of ions
US5154890A (en) * 1990-11-07 1992-10-13 Hewlett-Packard Company Fiber optic potassium ion sensor
US5187103A (en) * 1991-01-31 1993-02-16 Miles Inc. Colorimetric method and reagent for the assay of lithium in a test sample
US5245021A (en) * 1991-05-28 1993-09-14 Eastman Kodak Company 14-crown-4-ether derivatives
US5132436A (en) * 1991-05-28 1992-07-21 Eastman Kodak Company Intermediates for making 14-crown-4-ether derivatives
AT401823B (en) * 1993-09-30 1996-12-27 Avl Verbrennungskraft Messtech OPTICAL INDICATOR FOR DETERMINING THE ACTIVITY OF AN ION IN A SAMPLE
EP0758450B1 (en) * 1994-03-25 1998-08-05 Novartis AG Optical sensor for the determination of ions
EP0792454B1 (en) * 1994-11-14 2002-04-10 Bayer Corporation RANDOMLY SEGMENTED THERMOPLASTIC POLYURETHANES AS MATRIX FOR ELECTROCHEMICAL ANALYSIS OF Ca++ IONS
US5651876A (en) * 1995-03-02 1997-07-29 Orion Research Inc. Interference suppressing buffer
AT405103B (en) * 1996-10-16 1999-05-25 Avl Verbrennungskraft Messtech SENSOR LAYER FOR QUANTITATIVE DETERMINATION OF AT LEAST ONE CHEMICAL COMPONENT OF A GASEOUS OR LIQUID SAMPLE
AU5166198A (en) * 1996-11-08 1998-05-29 Mercury Diagnostics Inc. Opaque reaction matrix for the analysis of whole blood
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US6245574B1 (en) * 1997-07-03 2001-06-12 Novartis Ag Sensors
US6306347B1 (en) 1998-01-21 2001-10-23 Bayer Corporation Optical sensor and method of operation
US6254831B1 (en) 1998-01-21 2001-07-03 Bayer Corporation Optical sensors with reflective materials
US6190612B1 (en) 1998-01-21 2001-02-20 Bayer Corporation Oxygen sensing membranes and methods of making same
WO1999046582A1 (en) * 1998-03-10 1999-09-16 Metrika, Inc. Assay device, composition, and method of optimizing assay resolution
DK1077770T3 (en) 1998-05-13 2005-09-19 Bayer Ag Test introduction device
AT410719B (en) * 1998-06-30 2003-07-25 Hoffmann La Roche ION SENSOR
US6107083A (en) * 1998-08-21 2000-08-22 Bayer Corporation Optical oxidative enzyme-based sensors
US7157056B2 (en) * 1999-05-12 2007-01-02 Bayer Corporation Sample introduction device
KR100372559B1 (en) * 2000-08-14 2003-02-17 한국전력공사 Novel chromogenic calix[4]arene azacrown ether derivatives selectively adsorbing potassium ions
US7790112B2 (en) 2006-03-30 2010-09-07 Council of Scientific & Industual Research Biosensor to determine potassium concentration in human blood serum
KR20130020807A (en) * 2008-11-07 2013-02-28 에프. 호프만-라 로슈 아게 Fine-grained filler substances for photometric reaction films
US11553861B1 (en) 2018-05-29 2023-01-17 My Salt and Sugar, LLC Apparatus to detect salt concentrations and glucose in bodily fluids

Citations (6)

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US3856649A (en) * 1973-03-16 1974-12-24 Miles Lab Solid state electrode
EP0010615A1 (en) * 1978-10-02 1980-05-14 Roche Diagnostics GmbH Method and reagent for determining ions, polar and/or lipophilic compounds in liquids
US4234313A (en) * 1974-11-11 1980-11-18 Burroughs Wellcome Co. Device and method for quantitative uric acid testing
US4272485A (en) * 1978-12-27 1981-06-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Membranes for optodes
EP0041175A2 (en) * 1980-05-27 1981-12-09 Miles Inc. Ion specific analytical element
EP0085320A2 (en) * 1982-01-28 1983-08-10 MERCK PATENT GmbH Potassium reagent and process for the determination of potassium ions

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Publication number Priority date Publication date Assignee Title
US3856649A (en) * 1973-03-16 1974-12-24 Miles Lab Solid state electrode
US4234313A (en) * 1974-11-11 1980-11-18 Burroughs Wellcome Co. Device and method for quantitative uric acid testing
EP0010615A1 (en) * 1978-10-02 1980-05-14 Roche Diagnostics GmbH Method and reagent for determining ions, polar and/or lipophilic compounds in liquids
US4272485A (en) * 1978-12-27 1981-06-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Membranes for optodes
EP0041175A2 (en) * 1980-05-27 1981-12-09 Miles Inc. Ion specific analytical element
EP0085320A2 (en) * 1982-01-28 1983-08-10 MERCK PATENT GmbH Potassium reagent and process for the determination of potassium ions

Non-Patent Citations (1)

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Title
CLINICAL CHEMISTRY, volume 28, no. 9, September 1982, pages 1857-1861, Washington, US; S.C. CHARLTON et al.: "Solid-phase colorimetric determination of potassium" *

Also Published As

Publication number Publication date
EP0125555B1 (en) 1989-12-20
DK237584D0 (en) 1984-05-11
JPS59211864A (en) 1984-11-30
DK161262C (en) 1991-12-30
EP0125555A2 (en) 1984-11-21
FI841884A0 (en) 1984-05-10
FI77937B (en) 1989-01-31
FI77937C (en) 1989-05-10
ZA843496B (en) 1984-12-24
DK161262B (en) 1991-06-17
DK237584A (en) 1984-11-13
ES8507691A1 (en) 1985-09-01
JPH0423753B2 (en) 1992-04-23
ES532280A0 (en) 1985-09-01
CA1222438A (en) 1987-06-02
FI841884A (en) 1984-11-13
NO162132B (en) 1989-07-31
AU552420B2 (en) 1986-05-29
NO841748L (en) 1984-11-13
US4645744A (en) 1987-02-24
DE3480809D1 (en) 1990-01-25
AU2794184A (en) 1984-11-15
ATE48918T1 (en) 1990-01-15
NO162132C (en) 1989-11-08

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