EP0563795B1 - Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme - Google Patents
Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme Download PDFInfo
- Publication number
- EP0563795B1 EP0563795B1 EP93104952A EP93104952A EP0563795B1 EP 0563795 B1 EP0563795 B1 EP 0563795B1 EP 93104952 A EP93104952 A EP 93104952A EP 93104952 A EP93104952 A EP 93104952A EP 0563795 B1 EP0563795 B1 EP 0563795B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- enzyme
- electrically conductive
- mediator
- electrode
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C12Q1/003—Functionalisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Description
GOD (unmodified) | 100 |
Ferrocene | |
1 mg | |
Phosphate buffer (pH 6.0, 0.1 M) | 30 ml |
Catalase | 3 |
Glucose | |
10 mM or 0 mM |
Composition A | Composition B | |
Electrically conductive enzyme | 1.5 g | -- |
Carbon powder | 36.5 g | 36.5 |
Buffer | 15.0 g | 15.0 g |
Resin | 20.0 g | 20.0 g |
Surfactant (Kao Span 20) | 2.0 g | 2.0 g |
Butyl cellosolve | 15.0 g | 15.0 g |
Amyl alcohol | 10.0 g | 10.0 g |
Glucose concentration (mM) | 0 | 5 | 5 |
Unipolar electrode | 79 nA | 130 nA | 176 nA |
Bipolar electrode | 75 nA | 102 nA | 127 nA |
Fructose concentration (mM) | 0 | 5 | 5 |
| 60 nA | 64 nA | 66 nA |
Bipolar electrode | 45 nA | 52 nA | 55 nA |
Composition C | Composition D | |
Conductive enzyme | 0.610 | GOD 0.603 |
Ferrocene 0.007 | ||
Buffer | 10.000 | 10.000 |
Surfactant | 1.180 | 1.180 |
Resin | 14.040 | 14.040 |
Crystalline cellulose | 28.140 | 28.140 |
Carbon powder | 30.000 | 30.000 |
Amyl alcohol | 16.030 | 16.030 |
100.000 | 100.000 |
Claims (12)
- A composition for use in the preparation of an enzyme-immobilized electrode by a printing method, which comprises an electrically conductive enzyme, electrically conductive component, a binder resin and a vehicle for dissolving or dispersing said electrically conductive enzyme, said electrically conductive component and said binder resin, wherein said electrically conductive enzyme comprises an enzyme and a mediator attached to said enzyme through a covalent bond.
- The composition according to claim 1, further comprising a pH buffer.
- The composition according to claim 1 or 2, wherein said enzyme is an oxidase or a dehydrogenase.
- The composition according to claim 3, wherein said oxidase is selected from the group consisting of glucose oxidase, galactose oxidase, pyruvic acid oxidase, D- or L-amino acid oxidase, amine oxidase, cholesterol oxidase and choline oxidase.
- The composition according to claim 3, wherein said dehydrogenase is selected from the group consisting of alcohol dehydrogenase, glutamic acid dehydrogenase, cholesterol dehydrogenase, aldehyde dehydrogenase, glucose dehydrogenase, fructose dehydrogenase, sorbitol dehydrogenase and glycerol dehydrogenase.
- The composition according to any one of claims 1 to 5, wherein said mediator is selected from the group consisting of ferrocene, ferrocene derivatives, nicotinamide derivatives, flavin derivatives and quinone and quinone derivatives.
- The composition according to any one of claims 1 to 6, wherein said mediator is attached to a side chain and/or the main chain of the enzyme.
- The composition according to claim 8, wherein said enzyme is glucose oxidase and said mediator is introduced into the main chain of the enzyme and further introduced into the side chain of the enzyme through a spacer represented by the formula (I) according to claim 8.
- Use of a composition as defined in any one of claims 1 to 9 for the preparation of an enzyme-immobilized electrode by a printing method.
- A method for preparing an enzyme-immobilized electrode, comprising the steps of:applying the composition as defined in any one of claims 1 to 9 on a base material anddrying the composition to provide an enzyme-immobilized electrode.
- An enzyme-immobilized electrode comprising on a base material an electrically conductive enzyme, an electrically conductive component and a binder resin, wherein said electrically conductive enzyme comprises an enzyme and a mediator attached to said enzyme through a covalent bond.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP108706/92 | 1992-03-31 | ||
JP10870692 | 1992-03-31 | ||
JP4269552A JPH0690754A (en) | 1992-09-10 | 1992-09-10 | Enzyme modified through spacer with mediator and sensor involving the same modified enzyme |
JP269552/92 | 1992-09-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0563795A1 EP0563795A1 (en) | 1993-10-06 |
EP0563795B1 true EP0563795B1 (en) | 1998-07-22 |
Family
ID=26448544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93104952A Expired - Lifetime EP0563795B1 (en) | 1992-03-31 | 1993-03-25 | Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme |
Country Status (3)
Country | Link |
---|---|
US (1) | US5804047A (en) |
EP (1) | EP0563795B1 (en) |
DE (1) | DE69319771T2 (en) |
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Also Published As
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DE69319771T2 (en) | 1999-04-22 |
US5804047A (en) | 1998-09-08 |
DE69319771D1 (en) | 1998-08-27 |
EP0563795A1 (en) | 1993-10-06 |
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