EP0691122A3 - Method and apparatus for manufacturing tablets - Google Patents

Method and apparatus for manufacturing tablets Download PDF

Info

Publication number
EP0691122A3
EP0691122A3 EP95304529A EP95304529A EP0691122A3 EP 0691122 A3 EP0691122 A3 EP 0691122A3 EP 95304529 A EP95304529 A EP 95304529A EP 95304529 A EP95304529 A EP 95304529A EP 0691122 A3 EP0691122 A3 EP 0691122A3
Authority
EP
European Patent Office
Prior art keywords
manufacturing tablets
tablets
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP95304529A
Other languages
German (de)
French (fr)
Other versions
EP0691122A2 (en
EP0691122B1 (en
Inventor
Heizaburo Kato
Yuki Tsushima
Takayuki Ohwaki
Masaharu Nakajima
Yutaka Morita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Sankyo Manufacturing Co Ltd
Original Assignee
Eisai Co Ltd
Sankyo Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15589994A external-priority patent/JP3179658B2/en
Priority claimed from JP15734494A external-priority patent/JP3187657B2/en
Application filed by Eisai Co Ltd, Sankyo Manufacturing Co Ltd filed Critical Eisai Co Ltd
Publication of EP0691122A2 publication Critical patent/EP0691122A2/en
Publication of EP0691122A3 publication Critical patent/EP0691122A3/en
Application granted granted Critical
Publication of EP0691122B1 publication Critical patent/EP0691122B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/027—Particular press methods or systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/10—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable intermittently rotated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
EP95304529A 1994-07-07 1995-06-27 Method and apparatus for manufacturing tablets Expired - Lifetime EP0691122B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP15589994A JP3179658B2 (en) 1994-07-07 1994-07-07 Tablet manufacturing method and device
JP15589994 1994-07-07
JP155899/94 1994-07-07
JP15734494A JP3187657B2 (en) 1994-07-08 1994-07-08 Tablet manufacturing method and device
JP15734494 1994-07-08
JP157344/94 1994-07-08

Publications (3)

Publication Number Publication Date
EP0691122A2 EP0691122A2 (en) 1996-01-10
EP0691122A3 true EP0691122A3 (en) 1996-03-27
EP0691122B1 EP0691122B1 (en) 2000-12-13

Family

ID=26483794

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95304529A Expired - Lifetime EP0691122B1 (en) 1994-07-07 1995-06-27 Method and apparatus for manufacturing tablets

Country Status (6)

Country Link
US (3) US5672364A (en)
EP (1) EP0691122B1 (en)
KR (1) KR100357753B1 (en)
BR (1) BR9503100A (en)
DE (1) DE69519604T2 (en)
TW (1) TW333452B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104369411B (en) * 2014-11-05 2016-03-16 福建省尤溪县沈郎食用油有限公司 Automatic oil mill

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06218028A (en) * 1992-10-02 1994-08-09 Eisai Co Ltd Method and apparatus for molding wet-processed tablet, and the wet-processed tablet
US5672364A (en) * 1994-07-07 1997-09-30 Sankyo Seisakusho Co. & Eisai Co., Ltd. Apparatus for manufacturing tablets
ES2273409T3 (en) 1997-03-28 2007-05-01 Eisai Co., Ltd. ORAL MEDICINES THAT PREVENT UNFORGETTABLE AND SIMILAR FLAVOR.
US6465009B1 (en) 1998-03-18 2002-10-15 Yamanouchi Pharmaceutical Co., Ltd. Water soluble polymer-based rapidly dissolving tablets and production processes thereof
US6106267A (en) * 1998-06-05 2000-08-22 Aylward; John T. Apparatus for forming a compression-molded product
JP3737331B2 (en) * 1999-03-31 2006-01-18 Ｓｐｓシンテックス株式会社 Automatic powder filling method and apparatus
DK1260215T3 (en) * 2000-03-01 2009-11-09 Eisai R&D Man Co Ltd Rapid disintegrating tablet containing polyvinyl alcohol
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
CA2438907A1 (en) * 2001-02-15 2002-09-06 King Pharmaceuticals, Inc. Manufacture of thyroid hormone tablets having consistent active moiety amounts
US6706284B2 (en) 2001-03-15 2004-03-16 Yamanouchi Pharmaceutical Co., Ltd. Bitterness-reduced oral pharmaceutical composition
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US6767200B2 (en) * 2001-09-28 2004-07-27 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US6982094B2 (en) * 2001-09-28 2006-01-03 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7122143B2 (en) 2001-09-28 2006-10-17 Mcneil-Ppc, Inc. Methods for manufacturing dosage forms
ITRM20010723A1 (en) * 2001-12-07 2003-06-09 Sipa Spa DEVICE AND MOLDING METHOD FOR COMPRESSION OF PLASTIC ITEMS.
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP1465606A4 (en) * 2001-12-24 2009-04-22 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITBO20020094A1 (en) * 2002-02-22 2003-08-22 Tecnea Engineering S R L PROCEDURE FOR THE CONSTRUCTION OF COMPOSITIONS AND EQUIPMENT REALIZING SUCH PROCEDURE
DE10212959A1 (en) * 2002-03-22 2003-10-16 Wolfram Minke Machine, in particular, in the form of a tablet press comprises a die table which, in addition to a first circle of dies, is provided with a second circle of dies together with their respective top and bottom punches
ITRE20030012A1 (en) * 2003-01-31 2004-08-01 Sacmi "DOSE SEPARATION AND TRANSPORTATION DEVICE
EP1660313A1 (en) * 2003-08-25 2006-05-31 Alpex Pharma SA Tablet punches and method for tableting
GB0322358D0 (en) * 2003-09-24 2003-10-22 Bioprogress Technology Ltd Improvements in powder compaction and enrobing
EP1813274B1 (en) * 2004-10-06 2009-12-16 Eisai R&D Management Co., Ltd. Medicinal composition, process for producing the same, and method of stabilizing dihydropyridine compound in medicinal composition
JP5103173B2 (en) * 2005-04-28 2012-12-19 エルメッド エーザイ株式会社 Method for preventing decomposition of dihydropyridine compounds
KR20080039876A (en) * 2005-07-22 2008-05-07 미리어드 제네틱스, 인크. High drug load formulations and dosage forms
KR100650431B1 (en) * 2005-10-21 2006-11-29 주식회사 팜텍코리아 Powdered medical supplies supply equipment for rotary type pharmaceutical molding equipment
JP4918999B2 (en) * 2006-05-19 2012-04-18 クオリカプス株式会社 Powder compression molding machine and continuous production apparatus for powder compression molding using the molding machine
MD20060152A (en) * 2006-06-05 2007-12-31 Иван НЕКИТ Pressing machine (variants)
EP2038000B1 (en) * 2006-07-07 2010-10-20 CaridianBCT, Inc. Method for connecting thermoplastic tubes
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
US20090110716A1 (en) * 2007-10-31 2009-04-30 Frank Bunick Orally disintegrative dosage form
US8784781B2 (en) * 2009-09-24 2014-07-22 Mcneil-Ppc, Inc. Manufacture of chewing gum product with radiofrequency
US8858210B2 (en) * 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
JP5636719B2 (en) * 2010-03-30 2014-12-10 住友ベークライト株式会社 Molded body manufacturing apparatus and molded body manufacturing method
CN102370576B (en) * 2010-08-05 2013-09-04 黑龙江迪尔制药机械有限责任公司 Upper and lower shell positioning and buckling mechanism on Chinese medicinal large honeyed bolus automatic buckling machine
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
JP5889743B2 (en) * 2012-07-20 2016-03-22 住友重機械工業株式会社 Regenerative refrigerator
CN104411283B (en) * 2013-05-16 2019-01-04 科施股份公司 Device and method for being placed on film in tablet press machine
RU2526327C1 (en) * 2013-06-21 2014-08-20 Открытое акционерное общество "Федеральный научно-производственный центр "Научно-исследовательский институт прикладной химии" Method of manufacturing layered pyrotechnic charges
CN103358583A (en) * 2013-07-26 2013-10-23 四川省中药饮片有限责任公司 Automatic pressing machine for traditional Chinese medicine
ES2750323T3 (en) 2014-01-10 2020-03-25 Johnson & Johnson Consumer Inc Method for manufacturing a tablet using radio frequency and loss coated particles
US9937680B2 (en) * 2014-12-19 2018-04-10 Kamal Manku Pellet press machine
WO2017211520A1 (en) * 2016-06-08 2017-12-14 Schunk Kohlenstofftechnik Gmbh Device and method for producing a compression moulded body
WO2018047345A1 (en) * 2016-09-12 2018-03-15 日揮株式会社 Tablet processing facility
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
CN107336458A (en) * 2017-09-04 2017-11-10 苏州海森伯格环保科技有限公司 A kind of refuse disposal installation
CN107511907A (en) * 2017-09-04 2017-12-26 深圳永呈电子科技有限公司 A kind of chips fuel process equipment of natural environmental-protective
CN109094090A (en) * 2018-07-11 2018-12-28 曹美兰 A kind of numerical control rotary tablet press machine
CN110280187A (en) * 2019-08-06 2019-09-27 安徽环态生物能源科技开发有限公司 A kind of biomass granulation machine of ring moulds roller structure bilateral discharging
RU2712900C1 (en) * 2019-09-03 2020-01-31 Акционерное общество "Федеральный научно-производственный центр "Научно-исследовательский институт прикладной химии" Method for pressing pyrotechnic charges on automatic rotor lines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258335C (en) *
US2260456A (en) * 1939-07-20 1941-10-28 Allied Products Inc Method of and apparatus for forming rouge pads
US2886849A (en) * 1957-07-03 1959-05-19 Brierley Kenneth Powder-compressing machines
GB1221861A (en) * 1967-03-23 1971-02-10 Renato Altieri A machine for the automatic manufacture of compacted powder blocks

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1111879A (en) * 1914-01-30 1914-09-29 Arthur Colton Company Molding-machine.
US2573141A (en) * 1947-12-11 1951-10-30 Kolmar Laboratories Process of molding a cosmetic
US2512275A (en) * 1948-10-07 1950-06-20 Elwin A Hawk Apparatus for forming concave surfaced articles
GB1401070A (en) * 1972-12-19 1975-07-16 Holt M G Scott-maxwell d g machinery for moulding foodstuffs
ES485764A1 (en) * 1978-11-15 1980-10-01 Thomae Gmbh Dr K Method and apparatus for dotting moulding devices by means of discrete droplets of a liquid or suspended lubricant during the manufacture of moulded objects in the pharmaceutical, food or catalytic field.
US4450127A (en) * 1982-02-23 1984-05-22 Ptx Pentronix, Inc. Method for compacting powder material with adjustable die and punch assembly
US4605170A (en) * 1985-08-23 1986-08-12 Bayrisches Druckgusswerk Thurner Gmbh & Co. Kg Apparatus for wetting mold surfaces with a liquid
US4970044A (en) * 1988-03-30 1990-11-13 General Electric Company Compression molding using insulating films
US5407339A (en) * 1993-09-27 1995-04-18 Vector Corporation Triturate tablet machine
US5672364A (en) * 1994-07-07 1997-09-30 Sankyo Seisakusho Co. & Eisai Co., Ltd. Apparatus for manufacturing tablets
JP3133899B2 (en) * 1994-07-07 2001-02-13 株式会社三共製作所 Tablet manufacturing method and device
KR100590963B1 (en) * 2004-05-07 2006-06-19 기아자동차주식회사 Long slide type rail system for removable vehicle seat

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258335C (en) *
US2260456A (en) * 1939-07-20 1941-10-28 Allied Products Inc Method of and apparatus for forming rouge pads
US2886849A (en) * 1957-07-03 1959-05-19 Brierley Kenneth Powder-compressing machines
GB1221861A (en) * 1967-03-23 1971-02-10 Renato Altieri A machine for the automatic manufacture of compacted powder blocks

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104369411B (en) * 2014-11-05 2016-03-16 福建省尤溪县沈郎食用油有限公司 Automatic oil mill

Also Published As

Publication number Publication date
TW333452B (en) 1998-06-11
US6074586A (en) 2000-06-13
EP0691122A2 (en) 1996-01-10
DE69519604T2 (en) 2001-04-12
KR100357753B1 (en) 2003-05-01
DE69519604D1 (en) 2001-01-18
EP0691122B1 (en) 2000-12-13
KR960003699A (en) 1996-02-23
BR9503100A (en) 1996-04-23
US6227836B1 (en) 2001-05-08
US5672364A (en) 1997-09-30

Similar Documents

Publication Publication Date Title
EP0691122A3 (en) Method and apparatus for manufacturing tablets
EP0691121A3 (en) Method and apparatus for manufacturing tablets
GB2300072B (en) Microcooling device and method for the production thereof
EP0809540A4 (en) Method and apparatus for making retaining elements
GB2314359B (en) Apparatus and method for facilitating well completion
EP0667147A3 (en) Process and apparatus for making tablets and tablets made therefrom.
GB2295923B (en) Method and apparatus for manufacturing semiconductor device
GB9309216D0 (en) Method and apparatus for manufacturing fitting members
EP0726104A3 (en) Pressing method and pressing apparatus for the same
PL321850A1 (en) Can forming method and apparatus
SG55070A1 (en) Method and apparatus for manufacturing marble candy
GB2291371B (en) Hole forming method and apparatus
GB2289982B (en) Apparatus and method for manufacturing wafer
EP0720035A3 (en) Illuminating apparatus and device manufacturing method
EP0753467A4 (en) Bag-in-carton and method of and apparatus for manufacturing the same
GB2295576B (en) De-laminator apparatus and method
AU2321495A (en) Method and apparatus for forming cages
GB2275413B (en) Method and Apparatus for Garment Manufacturing
AUPM349394A0 (en) Method and apparatus for forming pads
GB9626480D0 (en) Crimped elements and methods and apparatus for making same
IL110524A (en) Method and machine for manufacturing jewellery
HU9502423D0 (en) Procedure and apparatus for manufacturing plasticized celluloze-nitrate
KR970009874B1 (en) Method and apparatus for manufacturing continuous slide fastener elements
GB9515258D0 (en) Apparatus and method for manufacturing popcorn
HU9501515D0 (en) Boundary-stone, method for place out and apparatus for making boundary-stones

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): CH DE FR GB IT LI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): CH DE FR GB IT LI

17P Request for examination filed

Effective date: 19960801

17Q First examination report despatched

Effective date: 19990421

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE FR GB IT LI

ITF It: translation for a ep patent filed

Owner name: JACOBACCI & PERANI S.P.A.

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: A. BRAUN, BRAUN, HERITIER, ESCHMANN AG PATENTANWAE

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 69519604

Country of ref document: DE

Date of ref document: 20010118

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

REG Reference to a national code

Ref country code: FR

Ref legal event code: TQ

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUEA

Owner name: SANKYO SEISAKUSHO CO.

Free format text: EISAI CO., LTD.#6-10, KOISHIKAWA 4-CHOME BUNKYO-KU#TOKYO (JP) $ SANKYO SEISAKUSHO CO.#37-3, TABATASHINMACHI-3-CHOME, KITA-KU#TOKYO (JP) -TRANSFER TO- SANKYO SEISAKUSHO CO.#37-3, TABATASHINMACHI-3-CHOME, KITA-KU#TOKYO (JP) $ EISAI R & D MANAGEMENT CO., LTD.#6-10, KOISHIKAWA 4-CHOME#BUNKYO-KU, TOKYO (JP)

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: SANKYO SEISAKUSHO CO.

Free format text: SANKYO SEISAKUSHO CO.#37-3, TABATASHINMACHI-3-CHOME, KITA-KU#TOKYO (JP) $ EISAI R & D MANAGEMENT CO., LTD.#6-10, KOISHIKAWA 4-CHOME#BUNKYO-KU, TOKYO (JP) -TRANSFER TO- SANKYO SEISAKUSHO CO.#37-3, TABATASHINMACHI-3-CHOME, KITA-KU#TOKYO (JP) $ EISAI R & D MANAGEMENT CO., LTD.#6-10, KOISHIKAWA 4-CHOME#BUNKYO-KU, TOKYO (JP)

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20100621

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20100618

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20100623

Year of fee payment: 16

Ref country code: FR

Payment date: 20100720

Year of fee payment: 16

Ref country code: DE

Payment date: 20100607

Year of fee payment: 16

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20110627

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110627

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20120229

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69519604

Country of ref document: DE

Effective date: 20120103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120103

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20110627