EP0935753A4 - Assay and cell line for the identification of growth hormone mimetics - Google Patents

Assay and cell line for the identification of growth hormone mimetics

Info

Publication number
EP0935753A4
EP0935753A4 EP97946307A EP97946307A EP0935753A4 EP 0935753 A4 EP0935753 A4 EP 0935753A4 EP 97946307 A EP97946307 A EP 97946307A EP 97946307 A EP97946307 A EP 97946307A EP 0935753 A4 EP0935753 A4 EP 0935753A4
Authority
EP
European Patent Office
Prior art keywords
assay
identification
cell line
growth hormone
hormone mimetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946307A
Other languages
German (de)
French (fr)
Other versions
EP0935753A1 (en
Inventor
Charles I Rosenblum
Aurawan Vongskierttikachor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0935753A1 publication Critical patent/EP0935753A1/en
Publication of EP0935753A4 publication Critical patent/EP0935753A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/61Growth hormones [GH] (Somatotropin)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP97946307A 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics Withdrawn EP0935753A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2923796P 1996-10-31 1996-10-31
US29237P 1996-10-31
PCT/US1997/019350 WO1998019158A1 (en) 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics

Publications (2)

Publication Number Publication Date
EP0935753A1 EP0935753A1 (en) 1999-08-18
EP0935753A4 true EP0935753A4 (en) 1999-12-08

Family

ID=21847984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97946307A Withdrawn EP0935753A4 (en) 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics

Country Status (3)

Country Link
EP (1) EP0935753A4 (en)
CA (1) CA2270179A1 (en)
WO (1) WO1998019158A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140058A0 (en) * 1998-06-30 2002-02-10 Procter & Gamble Methods for inhibiting tef-3 activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019485A1 (en) * 1993-02-19 1994-09-01 Edison Animal Biotechnology Center, Ohio University A method for detecting compounds with growth hormone and growth hormone receptor activity
US5436128A (en) * 1990-08-07 1995-07-25 Salk Institute Biotechnology/Industrial Associates Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5506102A (en) * 1993-10-28 1996-04-09 Ligand Pharmaceuticals Incorporated Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436128A (en) * 1990-08-07 1995-07-25 Salk Institute Biotechnology/Industrial Associates Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal
WO1994019485A1 (en) * 1993-02-19 1994-09-01 Edison Animal Biotechnology Center, Ohio University A method for detecting compounds with growth hormone and growth hormone receptor activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOUJON L ET AL: "Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1994 FEB 1) 91 (3) 957-61., XP002117555 *
See also references of WO9819158A1 *

Also Published As

Publication number Publication date
WO1998019158A1 (en) 1998-05-07
CA2270179A1 (en) 1998-05-07
EP0935753A1 (en) 1999-08-18

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