EP1027061A4 - Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants - Google Patents

Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants

Info

Publication number
EP1027061A4
EP1027061A4 EP98949701A EP98949701A EP1027061A4 EP 1027061 A4 EP1027061 A4 EP 1027061A4 EP 98949701 A EP98949701 A EP 98949701A EP 98949701 A EP98949701 A EP 98949701A EP 1027061 A4 EP1027061 A4 EP 1027061A4
Authority
EP
European Patent Office
Prior art keywords
adjuvants
immunostimulants
imine
preparation
forming polysaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98949701A
Other languages
German (de)
French (fr)
Other versions
EP1027061B1 (en
EP1027061A1 (en
Inventor
Dante J Marciani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galenica Pharmaceuticals Inc
Original Assignee
Galenica Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenica Pharmaceuticals Inc filed Critical Galenica Pharmaceuticals Inc
Priority to EP05010613A priority Critical patent/EP1574217A1/en
Publication of EP1027061A1 publication Critical patent/EP1027061A1/en
Publication of EP1027061A4 publication Critical patent/EP1027061A4/en
Application granted granted Critical
Publication of EP1027061B1 publication Critical patent/EP1027061B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.
EP98949701A 1997-10-03 1998-10-02 Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants Expired - Lifetime EP1027061B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05010613A EP1574217A1 (en) 1997-10-03 1998-10-02 Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6078697P 1997-10-03 1997-10-03
US60786P 1997-10-03
PCT/US1998/020660 WO1999017783A1 (en) 1997-10-03 1998-10-02 Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP05010613A Division EP1574217A1 (en) 1997-10-03 1998-10-02 Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants

Publications (3)

Publication Number Publication Date
EP1027061A1 EP1027061A1 (en) 2000-08-16
EP1027061A4 true EP1027061A4 (en) 2000-12-13
EP1027061B1 EP1027061B1 (en) 2005-05-25

Family

ID=22031745

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98949701A Expired - Lifetime EP1027061B1 (en) 1997-10-03 1998-10-02 Imine-forming polysaccharides, preparation thereof and the use thereof as adjuvants and immunostimulants

Country Status (14)

Country Link
US (2) US6960344B2 (en)
EP (1) EP1027061B1 (en)
JP (1) JP2001518556A (en)
KR (1) KR100680014B1 (en)
AT (1) ATE296105T1 (en)
AU (1) AU9597198A (en)
BR (1) BR9815388A (en)
CA (1) CA2305599A1 (en)
DE (1) DE69830326T2 (en)
ES (1) ES2245805T3 (en)
IL (1) IL135148A0 (en)
MX (1) MXPA00003108A (en)
NZ (1) NZ503488A (en)
WO (1) WO1999017783A1 (en)

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US20040126272A1 (en) * 2002-08-28 2004-07-01 Eric Bornstein Near infrared microbial elimination laser system
CA2522213A1 (en) * 2003-04-08 2004-10-28 Dante J. Marciani Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
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US8268952B2 (en) * 2004-07-12 2012-09-18 Suprapolix B.V. Supramolecular ionomers
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US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
ES2376888T3 (en) 2005-05-04 2012-03-20 Suprapolix B.V. Biologically active, bio-absorbable or biomedical modular supramolecular materials
ES2367583T3 (en) * 2005-05-04 2011-11-10 Suprapolix B.V. HYDROGELS WITH HYDROGEN LINKS.
AU2006283726C1 (en) 2005-08-24 2015-05-07 Immunogen, Inc. Process for preparing maytansinoid antibody conjugates
CA2653390C (en) 2006-06-02 2014-07-08 Hawaii Chitopure, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US20100076147A1 (en) * 2006-11-20 2010-03-25 Suprapolix B.V. Supramolecular polymers from low-melting, easily processable building blocks
US8628789B2 (en) 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
JP5350626B2 (en) * 2007-12-20 2013-11-27 キリンフードテック株式会社 Dendritic cell activation composition
US8754213B2 (en) * 2008-07-04 2014-06-17 Suprapolix B.V. High flow supramolecular compounds
WO2010030366A2 (en) 2008-09-11 2010-03-18 Nektar Therapeutics Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method
ES2726945T3 (en) 2009-06-03 2019-10-10 Immunogen Inc Conjugation Methods
CN101791410B (en) * 2010-01-25 2013-03-27 中国药科大学 Preparation and application of conjugate of anti-infective medicament and polysaccharide and medicinal composition thereof
EP2450394B1 (en) 2010-11-05 2017-06-07 SupraPolix B.V. A process for the preparation of a supramolecular polymer
EP4324483A3 (en) 2011-01-14 2024-05-01 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto
WO2013109292A1 (en) * 2011-02-16 2013-07-25 The University Of Akron A highly selective pyrophosphate sensor
ME03353B (en) 2011-03-29 2019-10-20 Immunogen Inc Preparation of maytansinoid antibody conjugates by a one-step process
WO2013067597A1 (en) * 2011-11-09 2013-05-16 Ascend Biopharmaceuticals Pty Ltd Immunomodulatory conjugates
TW201340980A (en) * 2012-04-10 2013-10-16 Taiwan Hopax Chems Mfg Co Ltd Metal-polysaccharide conjugates: composition, synthesis and methods for cancer
CN102626518B (en) * 2012-05-09 2014-05-28 中国药科大学 Preparation and application of insoluble drug-entrapped poloxamer/amphiphilic polysaccharide mixed micelle
NZ707091A (en) 2012-10-04 2018-12-21 Immunogen Inc Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
US9402925B2 (en) 2013-03-12 2016-08-02 The Board Of Trustees Of The Leland Stanford Junio Probes and methods of imaging a bacterial infection
WO2016176510A1 (en) * 2015-04-28 2016-11-03 University Of Georgia Research Foundation, Inc. Piv5-based amplifying virus-like particles
CN107261130A (en) * 2017-06-29 2017-10-20 云南沃森生物技术股份有限公司 It is a kind of with preparation methods of the DSC as the bacterial polysaccharide protein combined vaccine of activator
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CA3213390A1 (en) * 2021-03-12 2022-09-15 Children's Medical Center Corporation Polysaccharide adjuvants for virus vaccines
US11572420B1 (en) 2021-07-30 2023-02-07 Tissue repair ltd Isolated biological polysaccharide compound, methods of use and methods of manufacture thereof
US11384160B1 (en) * 2021-07-30 2022-07-12 Tissue repair ltd Method of making a beta glucan compound
CN114805637B (en) * 2022-05-31 2023-02-03 中国科学院海洋研究所 Marine organism polysaccharide Schiff base derivative and preparation method and application thereof

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Also Published As

Publication number Publication date
WO1999017783A1 (en) 1999-04-15
CA2305599A1 (en) 1999-04-15
EP1027061B1 (en) 2005-05-25
JP2001518556A (en) 2001-10-16
KR20010030878A (en) 2001-04-16
BR9815388A (en) 2001-08-21
DE69830326D1 (en) 2005-06-30
US7196073B2 (en) 2007-03-27
US6960344B2 (en) 2005-11-01
AU9597198A (en) 1999-04-27
US20040220142A1 (en) 2004-11-04
KR100680014B1 (en) 2007-02-09
EP1027061A1 (en) 2000-08-16
ES2245805T3 (en) 2006-01-16
ATE296105T1 (en) 2005-06-15
DE69830326T2 (en) 2006-02-02
NZ503488A (en) 2001-08-31
MXPA00003108A (en) 2001-07-01
IL135148A0 (en) 2001-05-20
US20020150585A1 (en) 2002-10-17

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

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