EP1038535A3 - Use of selected perfluorocarbons for the preparation of diagnostic ultrasound contrast agents - Google Patents

Use of selected perfluorocarbons for the preparation of diagnostic ultrasound contrast agents Download PDF

Info

Publication number
EP1038535A3
EP1038535A3 EP00109817A EP00109817A EP1038535A3 EP 1038535 A3 EP1038535 A3 EP 1038535A3 EP 00109817 A EP00109817 A EP 00109817A EP 00109817 A EP00109817 A EP 00109817A EP 1038535 A3 EP1038535 A3 EP 1038535A3
Authority
EP
European Patent Office
Prior art keywords
preparation
contrast agents
ultrasound contrast
diagnostic ultrasound
perfluorocarbons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00109817A
Other languages
German (de)
French (fr)
Other versions
EP1038535A2 (en
Inventor
Steven C. Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Priority claimed from EP94908587A external-priority patent/EP0680341B1/en
Publication of EP1038535A2 publication Critical patent/EP1038535A2/en
Publication of EP1038535A3 publication Critical patent/EP1038535A3/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Use of perfluorocarbons having a boiling point above 40°C and a vapor pressure at ambient temperature above 2660 Pa (20 Torr) for the preparation of ultrasound contrast agents.
EP00109817A 1993-01-25 1994-01-19 Use of selected perfluorocarbons for the preparation of diagnostic ultrasound contrast agents Withdrawn EP1038535A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8172 1993-01-25
US08/008,172 US5558855A (en) 1993-01-25 1993-01-25 Phase shift colloids as ultrasound contrast agents
US148284 1993-11-08
US08/148,284 US5595723A (en) 1993-01-25 1993-11-08 Method for preparing storage stable colloids
EP94908587A EP0680341B1 (en) 1993-01-25 1994-01-19 Phase shift colloids as ultrasound contrast agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP94908587A Division EP0680341B1 (en) 1993-01-25 1994-01-19 Phase shift colloids as ultrasound contrast agents

Publications (2)

Publication Number Publication Date
EP1038535A2 EP1038535A2 (en) 2000-09-27
EP1038535A3 true EP1038535A3 (en) 2003-10-29

Family

ID=21730155

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00109817A Withdrawn EP1038535A3 (en) 1993-01-25 1994-01-19 Use of selected perfluorocarbons for the preparation of diagnostic ultrasound contrast agents

Country Status (8)

Country Link
US (3) US5558855A (en)
EP (1) EP1038535A3 (en)
KR (1) KR100332166B1 (en)
MY (1) MY130909A (en)
PL (1) PL176870B1 (en)
RU (1) RU2131744C1 (en)
TW (1) TW377297B (en)
ZA (1) ZA94508B (en)

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US5595723A (en) 1997-01-21
ZA94508B (en) 1994-09-05
TW377297B (en) 1999-12-21
MY130909A (en) 2007-07-31
US5558855A (en) 1996-09-24
KR100332166B1 (en) 2002-11-16
US5707606A (en) 1998-01-13

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