EP1119375A4 - Methods and adjuvants for stimulating mucosal immunity - Google Patents
Methods and adjuvants for stimulating mucosal immunityInfo
- Publication number
- EP1119375A4 EP1119375A4 EP99949664A EP99949664A EP1119375A4 EP 1119375 A4 EP1119375 A4 EP 1119375A4 EP 99949664 A EP99949664 A EP 99949664A EP 99949664 A EP99949664 A EP 99949664A EP 1119375 A4 EP1119375 A4 EP 1119375A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- adjuvants
- methods
- mucosal immunity
- stimulating mucosal
- stimulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US167039 | 1988-03-11 | ||
US16703998A | 1998-10-05 | 1998-10-05 | |
PCT/US1999/021203 WO2000020039A1 (en) | 1998-10-05 | 1999-09-15 | Methods and adjuvants for stimulating mucosal immunity |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1119375A1 EP1119375A1 (en) | 2001-08-01 |
EP1119375A4 true EP1119375A4 (en) | 2005-02-02 |
Family
ID=22605695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99949664A Withdrawn EP1119375A4 (en) | 1998-10-05 | 1999-09-15 | Methods and adjuvants for stimulating mucosal immunity |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1119375A4 (en) |
JP (1) | JP2002526425A (en) |
AU (1) | AU776288B2 (en) |
CA (1) | CA2346452A1 (en) |
WO (1) | WO2000020039A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
AU4343700A (en) | 1999-04-12 | 2000-11-14 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Oligodeoxynucleotide and its use to induce an immune response |
WO2001051500A1 (en) | 2000-01-14 | 2001-07-19 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
WO2001055341A2 (en) | 2000-01-31 | 2001-08-02 | The Regents Of The University Of California | Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen |
WO2001072123A1 (en) | 2000-03-28 | 2001-10-04 | The Regents Of The University Of California | Methods for increasing a cytotoxic t lymphocyte response in vivo |
US7682607B2 (en) | 2001-05-01 | 2010-03-23 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
CN1753687A (en) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Use of cpg oligonucleotides in the treatment of hepatitis c virus infection |
CA2504493C (en) | 2002-11-01 | 2015-12-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of preventing infections from bioterrorism agents with immunostimulatory cpg oligonucleotides |
WO2004053104A2 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5’ cpg nucleic acids and methods of use |
WO2004100965A1 (en) | 2003-05-15 | 2004-11-25 | Japan Science And Technology Agency | Immunostimulant |
JP4817625B2 (en) * | 2003-08-11 | 2011-11-16 | 一般財団法人阪大微生物病研究会 | Novel vaccine containing mucosal immunity induction adjuvant |
WO2006060710A2 (en) * | 2004-12-02 | 2006-06-08 | Becton, Dickinson And Company | Vaccine formulations for intradermal delivery comprising adjuvants and antigenic agents |
EP1930025B1 (en) | 2005-08-05 | 2013-05-01 | The University of Tokushima | ANTIGEN-AND-DRUG VEHICLE WHICH ENABLES THE CHANGEOVER FROM THE SELECTIVE PRODUCTION OF IgA ANTIBODY TO THE PRODUCTION OF BOTH OF IgA AND IgG ANTIBODIES, AND TRANSNASAL/TRANSMUCOSAL VACCINE USING THE VEHICLE |
IL208820A0 (en) * | 2010-10-19 | 2011-01-31 | Rachel Teitelbaum | Biologic female contraceptives |
IL296071A (en) * | 2020-03-01 | 2022-11-01 | Valneva Austria Gmbh | Cpg-adjuvanted sars-cov-2 virus vaccine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002555A1 (en) * | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2241042T3 (en) * | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | IMMUNO STIMULATOR POLINUCLEOTIDE CONJUGATES / IMMUNOMODULATOR MOLECULA. |
CA2301575C (en) * | 1997-05-20 | 2003-12-23 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
ATE353657T1 (en) * | 1997-09-05 | 2007-03-15 | Univ California | USE OF IMMUNE STIMULANT OLIGONUCLEOTIDES TO PREVENT OR TREAT ASTHMA |
-
1999
- 1999-09-15 AU AU62493/99A patent/AU776288B2/en not_active Expired - Fee Related
- 1999-09-15 EP EP99949664A patent/EP1119375A4/en not_active Withdrawn
- 1999-09-15 JP JP2000573397A patent/JP2002526425A/en not_active Withdrawn
- 1999-09-15 CA CA002346452A patent/CA2346452A1/en not_active Abandoned
- 1999-09-15 WO PCT/US1999/021203 patent/WO2000020039A1/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002555A1 (en) * | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
Non-Patent Citations (4)
Title |
---|
DAVIS H L ET AL: "CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 1998, vol. 160, no. 2, 15 January 1998 (1998-01-15), pages 870 - 876, XP002109526, ISSN: 0022-1767 * |
KRIEG ARTHUR M ET AL: "The role of CpG dinucleotides in DNA vaccines", TRENDS IN MICROBIOLOGY, vol. 6, no. 1, January 1998 (1998-01-01), pages 23 - 27, XP000857633, ISSN: 0966-842X * |
See also references of WO0020039A1 * |
WEINER GEORGE J ET AL: "Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 20, 1997, pages 10833 - 10837, XP002120387, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
AU776288B2 (en) | 2004-09-02 |
AU6249399A (en) | 2000-04-26 |
EP1119375A1 (en) | 2001-08-01 |
WO2000020039A9 (en) | 2000-09-21 |
CA2346452A1 (en) | 2000-04-13 |
WO2000020039A1 (en) | 2000-04-13 |
JP2002526425A (en) | 2002-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010427 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20041221 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 39/39 B Ipc: 7C 12N 15/00 B Ipc: 7A 61K 48/00 A |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050331 |