EP1156759A4 - Biodegradable polymeriprotein based coils for intralumenal implants - Google Patents
Biodegradable polymeriprotein based coils for intralumenal implantsInfo
- Publication number
- EP1156759A4 EP1156759A4 EP99951622A EP99951622A EP1156759A4 EP 1156759 A4 EP1156759 A4 EP 1156759A4 EP 99951622 A EP99951622 A EP 99951622A EP 99951622 A EP99951622 A EP 99951622A EP 1156759 A4 EP1156759 A4 EP 1156759A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- coil
- biocompatible
- protein
- growth factor
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Definitions
- the invention relates generally to the field of surgical and endovascular interventional instruments and specially to Intraluminal implants for occlusion of vessels or aneurysms.
- Brain aneurysms are the commonest cause of nontraumatic subarachnoid hemorrhage (SAH) which is a significant life-threatening disease in adults. Annually in North America, the rupture of saccular aneurysms accounts for 25000 new cases of SAH. Microsurgical clipping of an aneurysm has been considered the gold standard for the treatment of this disease. Recently, intravascular treatment of aneurysms has become an accepted alternative technique. With the availability of microcatheters capable of accessing the intracranial circulation it has become possible to obliterate an aneurysm by filling it with soft platinum detachable coils (Guglielmi Detachable Coils; GDC).
- GDC Global System for Delivery and detachment of platinum coils within an aneurysm.
- Recent advances in endovascular techniques have proved valuable in the treatment of cerebral saccular aneurysms.
- GDCs have contributed especially to improvements in the endovascular management of cerebral aneurysms.
- the size of an aneurysm neck has an important effect on the anatomic results of aneurysm obliteration. It has been reported that in one study complete obliteration of aneurysms was achieved in 85% of small-necked aneurysms and 15% of wide-necked aneurysms.
- GDCs Guglielmi detachable coils
- Occlusion coils are used to occlude a site within a body lumen, such as a blood vessel, brain aneurysm, or vascular malformation.
- the coils are typically placed at a desired site within the lumen by means of a microcatheter.
- the coils are normally made of a radioopaque, biocompatible metals such as platinum, gold, or tungsten.
- the coils occlude the aneurysm by posing a physical barrier to blood flow and by promoting thrombus formation.
- the formation of the neo-endothelium and mature intra-aneurysmal thrombus is necessary prior to subsequent organization and scar formation that, in turn, yields a permanently occluded aneurysm.
- metallic coils can be insufficiently thrombogenic to promote the establishment of firm and mature thrombus within the aneurysm. They have difficulty in promoting endothelialization across the wide neck of an aneurysm. Therefore, it is advantageous to tightly pack the aneurysm with coils for complete cure of the aneurysms. This may cause a mass effect on adjacent the brain parenchyma or cranial nerves.
- Bioabsorbable polymers such as polyglycolic acid and polyglycolic/poly-L-lactic acid copolymers, or bioabsorbable proteins, such as collagen and gelatins, have been used to make Intraluminal implants. These bioabsorbable polymers or proteins are also used to provide a the drug delivery vehicle (such as for continuous local delivery of growth factors). It is necessary to modify biological cellular response in preparation for acceleration of wound healing.
- Coil thrombogenicity was enhanced previously by increasing the surface area of the coils with fabric strands, such as Dacron, and by placing such coils into a thrombin solution. More recently, some investigators have modified the surfaces of platinum coils by coating them with collagen or polyurethane. This has resulted in some advantages, such as an increase in thrombogenicity of these coils.
- protein coatings on platinum surfaces are usually weak and may be removed easily during the delivery of the coils. Additionally, weakly coated proteins may be washed off by high-velocity arterial flow and may be a potential source of distal thromboemboli.
- polyurethane coatings in particular also have the disadvantage of producing unfavorable changes in GDC performance, affecting their softness, thinness, smoothness,
- GDCs and surrounding thrombus within an aneurysm are continuously exposed to and interact with circulating blood at the neck of the aneurysm.
- Coil compaction resulting from the force of pulsatile arterial blood flow is one of the reasons for incomplete obliteration of aneurysms. When this occurs, there is a potential risk of aneurysm recanalization and (re)rupture.
- Re- endothelialization and the promotion of wound healing in the aneurysmal sac and across its neck are necessary for complete aneurysm cure.
- the invention is an intravascular device that modifies either accelerating or decreasing biological cellular response comprising a separable tip or coil comprised at least in part of at least one biocompatible and absorbable polymer or protein, and a placement device associated with the separable coil adapted to dispose the coil into a selected body lumen.
- the biocompatible and absorbable polymer or protein promotes an intra-aneurysmal inflammatory response and healing of the aneurysms.
- This device may carry growth factors, such as a vascular endothelial growth factor, a basic fibroblast growth factor or a mixture of several growth factors or cytokines.
- the separable tip which also need not be a coil, need not be comprised of a polymer or protein, but may be comprised of any material now known or later devised which is biocompatible, absorbable and which promotes an intra-aneurysmal inflammatory response and promotes healing of the aneurysm.
- the biocompatible and absorbable polymer is in the illustrated embodiment at least one polymer selected from the group consisting of polyglycolic acid, poly ⁇ glycolic acid/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L- lactide, polydioxanone, polycarbonates, and polyanhydrides.
- the biocompatible and absorbable protein is at least one protein selected from the group consisting of collagen, fibrinogen, fibronectin, vitronectin, laminin, and gelatin.
- the coil is composed of the biocompatible and absorbable polymer or protein with a radio-opaque material is disposed thereon.
- the coil is composed of a radio-opaque material, and the biocompatible and absorbable polymer or protein is disposed thereon.
- the invention is also characterized as a method for forming a thrombus comprising the steps of providing a separable coil comprised at least in part of at least one biocompatible and absorbable polymer or protein and disposing the separable coil into a body lumen including the various combinations and examples described above.
- the method further of comprises the step of providing the coil with a growth factor, and in particular a vascular endothelial growth factor (VEGF), a basic fibroblast growth factor (bFGF), or other growth factors.
- a growth factor and in particular a vascular endothelial growth factor (VEGF), a basic fibroblast growth factor (bFGF), or other growth factors.
- VEGF vascular endothelial growth factor
- bFGF basic fibroblast growth factor
- a biodegradable polymer (or protein) coils are used to control thrombosis or accelerate wound healing of the brain aneurysms for which platinum coils sometimes have often proven unsatisfactory.
- Another aspect of the invention is a method of drug delivery system using biodegradable polymer (or proteins) in the combination with growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or other growth factors which promote long lasting effect of the wound healing
- growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or other growth factors which promote long lasting effect of the wound healing
- biodegradable coils are useful for treating giant brain aneurysms to prevent the mass effect on the brain parenchyma or cranial nerves by shrinkage of scaring aneurysm.
- the implants of the invention may be placed within body lumens, e.g., blood vessels, Fallopian tubes, etc., of any mammalian species, including humans.
- the implant coils are made of biocompatible and absorbable polymers or proteins.
- bioabsorbable polymers that have been used in the illustrated embodiment to make Intraluminal implants include but are not limited to polyglycolic acid, poly ⁇ gycolic/poly-L-lactic acid copolymers, polycaprolactive, polyhydroxybutyrate /hydroxyvalerate copolymers, poly-L-lactide, polydioxanone, polycarbonates, and polyanhydrides.
- bioabsorbable proteins that have been used in the illustrated embodiment to make Intraluminal implants include but are not limited to collagen, fibrinogen, fibronectin, vitronectin, laminin and gelatin.
- the bioabsorbable polymer coils may be coated or mixed with radioopaque materials such as tantalum or platinum.
- the bioabsorbable polymer or protein itself may be mounted or coated onto coils or wires of metals such as platinum or nitonol.
- Preferred growth factors for use in the invention are the naturally occurring mammalian angiogenic growth such as VEGF, or b-FGF. Mixtures of such growth factors may also be used if desired.
- the biodegradable polymer coils of the invention can be placed within the body lumen, vascular system or vessels using procedures well known in the art.
- the desired site within the vessel is accessed with a catheter.
- the catheter may be guided to the site by the use of guide wires.
- the catheter lumen is cleared by removing guide wire.
- the coils are loaded by means of a pusher wire.
- the coils may be attached to the distal end of the pusher via a cleavable joint (e.g., a joint that is severable by heat, electrolysis, electrodynamic activation or other means) or a mechanical joint that permits the coil to be detached from the distal end of the pusher wire by mechanical manipulation.
- the coils may be free and detached from the pusher wire, simply pushed through the catheter and expelled from the distal end of the catheter.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
WOPCT/US99/01790 | 1999-01-27 | ||
PCT/US1999/001790 WO1999044538A1 (en) | 1998-01-27 | 1999-01-27 | Biodegradable polymer/protein based coils for intralumenal implants |
PCT/US1999/022420 WO2000044306A1 (en) | 1999-01-27 | 1999-09-27 | Biodegradable polymeriprotein based coils for intralumenal implants |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1156759A1 EP1156759A1 (en) | 2001-11-28 |
EP1156759A4 true EP1156759A4 (en) | 2002-11-20 |
Family
ID=22272061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99951622A Ceased EP1156759A4 (en) | 1999-01-27 | 1999-09-27 | Biodegradable polymeriprotein based coils for intralumenal implants |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1156759A4 (en) |
JP (3) | JP2003524456A (en) |
AU (1) | AU6402699A (en) |
CA (1) | CA2323151C (en) |
WO (1) | WO2000044306A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070607B2 (en) | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
US7018401B1 (en) | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
US6368346B1 (en) | 1999-06-03 | 2002-04-09 | American Medical Systems, Inc. | Bioresorbable stent |
US20030004533A1 (en) * | 2001-05-04 | 2003-01-02 | Concentric Medical | Bioactive polymer vaso-occlusive device |
US6585754B2 (en) | 2001-05-29 | 2003-07-01 | Scimed Life Systems, Inc. | Absorbable implantable vaso-occlusive member |
EP1411861B1 (en) | 2001-06-29 | 2012-04-04 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
US8715312B2 (en) | 2001-07-20 | 2014-05-06 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8252040B2 (en) | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
US7572288B2 (en) | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
US7879064B2 (en) | 2004-09-22 | 2011-02-01 | Micro Therapeutics, Inc. | Medical implant |
ATE448737T1 (en) | 2004-09-22 | 2009-12-15 | Dendron Gmbh | DEVICE FOR IMPLANTING MICROWL COILS |
CA2649702C (en) | 2006-04-17 | 2014-12-09 | Microtherapeutics, Inc. | System and method for mechanically positioning intravascular implants |
MX2009004292A (en) | 2006-10-22 | 2009-08-12 | Idev Technologies Inc | Devices and methods for stent advancement. |
EP3329882B1 (en) | 2006-10-22 | 2023-09-20 | IDEV Technologies, INC. | Methods for securing strand ends and the resulting devices |
KR20100015520A (en) | 2007-03-13 | 2010-02-12 | 마이크로 테라퓨틱스 인코포레이티드 | An implant including a coil and a stretch-resistant member |
WO2009003049A2 (en) | 2007-06-25 | 2008-12-31 | Micro Vention, Inc. | Self-expanding prosthesis |
US9023095B2 (en) | 2010-05-27 | 2015-05-05 | Idev Technologies, Inc. | Stent delivery system with pusher assembly |
DE102011007134A1 (en) | 2011-04-11 | 2012-10-11 | Basf Se | Process for the preparation of a polyamide by anionic polymerization |
JP2014522263A (en) | 2011-05-11 | 2014-09-04 | マイクロベンション インコーポレイテッド | Device for occluding a lumen |
US9579104B2 (en) | 2011-11-30 | 2017-02-28 | Covidien Lp | Positioning and detaching implants |
US9011480B2 (en) | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
US9687245B2 (en) | 2012-03-23 | 2017-06-27 | Covidien Lp | Occlusive devices and methods of use |
US9655999B2 (en) | 2013-03-12 | 2017-05-23 | Carnegie Mellon University | Coated vaso-occlusive device for treatment of aneurysms |
US9713475B2 (en) | 2014-04-18 | 2017-07-25 | Covidien Lp | Embolic medical devices |
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US4994069A (en) * | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
US5549624A (en) * | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
US5837008A (en) * | 1993-04-26 | 1998-11-17 | Medtronic, Inc. | Intravascular stent and method |
WO1999044538A1 (en) * | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
NO962336L (en) * | 1995-06-06 | 1996-12-09 | Target Therapeutics Inc | Vaso-occlusive spiral |
US5624461A (en) * | 1995-06-06 | 1997-04-29 | Target Therapeutics, Inc. | Three dimensional in-filling vaso-occlusive coils |
US5853418A (en) * | 1995-06-30 | 1998-12-29 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
DK0754435T3 (en) * | 1995-06-30 | 2000-11-27 | Target Therapeutics Inc | Stretch-resistant co-occlusion spirals |
CA2186768C (en) * | 1995-09-29 | 2000-12-12 | Pete Phong Pham | Anatomically shaped vasoocclusive devices |
US6007573A (en) * | 1996-09-18 | 1999-12-28 | Microtherapeutics, Inc. | Intracranial stent and method of use |
US5891192A (en) * | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
JP4355038B2 (en) * | 1997-09-01 | 2009-10-28 | 株式会社カネカメディックス | Vascular embolization device |
US5935145A (en) * | 1998-02-13 | 1999-08-10 | Target Therapeutics, Inc. | Vaso-occlusive device with attached polymeric materials |
US6015424A (en) * | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
-
1999
- 1999-09-27 AU AU64026/99A patent/AU6402699A/en not_active Abandoned
- 1999-09-27 JP JP2000595611A patent/JP2003524456A/en active Pending
- 1999-09-27 EP EP99951622A patent/EP1156759A4/en not_active Ceased
- 1999-09-27 WO PCT/US1999/022420 patent/WO2000044306A1/en active Search and Examination
- 1999-09-27 CA CA002323151A patent/CA2323151C/en not_active Expired - Lifetime
-
2004
- 2004-02-26 JP JP2004051278A patent/JP2004223268A/en active Pending
-
2005
- 2005-08-03 JP JP2005225833A patent/JP4751661B2/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994069A (en) * | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
US5837008A (en) * | 1993-04-26 | 1998-11-17 | Medtronic, Inc. | Intravascular stent and method |
US5549624A (en) * | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
WO1999044538A1 (en) * | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
Non-Patent Citations (3)
Title |
---|
MURAYAMA Y ET AL: "A new surface modification technique of platinum coils by ion implantation and protein coating: Use in intravascular treatment of brain aneurysms", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - B: BEAM INTERACTIONS WITH MATERIALS AND ATOMS, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. 127-128, 1 May 1997 (1997-05-01), pages 1015 - 1018, XP004096894, ISSN: 0168-583X * |
MURAYAMA Y ET AL: "ION IMPLANTATION AND PROTEIN COATING OF DETACHABLE COILS FOR ENDOVASCULAR TREATMENT OF CEREBRAL ANEURYSMS: CONCEPTS AND PRELIMINARY RESULTS IN SWINE MODELS", NEUROSURGERY, MCGRAW-HILL, NEW YORK, NY, US, vol. 40, no. 6, 1 June 1997 (1997-06-01), pages 1233 - 1244, XP002081170 * |
See also references of WO0044306A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP2003524456A (en) | 2003-08-19 |
JP4751661B2 (en) | 2011-08-17 |
WO2000044306A1 (en) | 2000-08-03 |
CA2323151C (en) | 2007-04-10 |
CA2323151A1 (en) | 2000-08-03 |
EP1156759A1 (en) | 2001-11-28 |
JP2006021052A (en) | 2006-01-26 |
AU6402699A (en) | 2000-08-18 |
JP2004223268A (en) | 2004-08-12 |
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