EP1233731A1 - Device for replacing a cardiac valve by percutaneous route - Google Patents
Device for replacing a cardiac valve by percutaneous routeInfo
- Publication number
- EP1233731A1 EP1233731A1 EP00979740A EP00979740A EP1233731A1 EP 1233731 A1 EP1233731 A1 EP 1233731A1 EP 00979740 A EP00979740 A EP 00979740A EP 00979740 A EP00979740 A EP 00979740A EP 1233731 A1 EP1233731 A1 EP 1233731A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- blades
- series
- valve
- elongated element
- wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
- A61B17/0218—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
Definitions
- the present invention relates to a device for replacing a heart valve by percutaneous route.
- the replacement of a defective heart valve is currently, most frequently, carried out by opening the thorax, putting the patient on extra-corporal circulation, temporary cardiac arrest, and opening the heart, with a view to excision and replacement of the valve.
- the invention aims to provide a device giving all satisfaction with regard to the excision and replacement of the valve, allowing intervention without opening the chest, cardiac arrest and / or opening of the heart, and to prevent any diffusion into the circulatory system of fragments of the valve removed.
- distal and proximal used below to describe the invention are defined with respect to the direction of flow of the blood.
- the device according to the invention comprises:
- a second series of blades arranged consecutively to said first series of blades in the distal direction; the blades of this second series of blades have a structure identical to that of the blades of said first series of blades, except that these blades of this second series are connected to the elongated element by their distal longitudinal ends and each have a cutting edge at the level of their proximal longitudinal end; - Means for bringing the blades of said first and second series of blades from their folding position to their unfolding position;
- the device according to the invention can be introduced percutaneously into said body duct and be slid into this duct until each of the series of aforementioned blades is placed on one side of the valve. This position is marked using said locating means.
- a peripheral perfusion or extracorporeal circulation system can be set up to facilitate the flow of blood, in order to prevent stagnation of blood in the heart.
- the blades of the two series of blades are deployed, then these two series are brought closer to each other until the valve is cut off.
- the conformation of these blades makes it possible to carry out this section in a single operation, therefore without generating fragments capable of being diffused in the circulatory system, or at least by generating very few such fragments; this conformation also allows precise control of the diameter according to which the native valve is sectioned, for the subsequent calibration of the prosthetic valve.
- the blades are then returned to the folded position.
- the prosthetic valve is then put in place.
- the device according to the invention comprises a proximal prosthetic valve, with a radially deployable structure, this prosthetic valve being able to occupy a folding position, in which it is located near the wall of said elongated element and does not obstruct the introduction and sliding of the device in said body duct, and an unfolding position, in which it bears against the wall of this duct and is able to replace the native heart valve.
- the device thus makes it possible to introduce and position the prosthetic valve at the appropriate place in the body conduit, by the same gesture as that making it possible to cut the native valve. After cutting the latter, the device is slid axially in the distal direction in order to bring the prosthetic valve to the appropriate level in this conduit, after which this prosthetic valve is deployed. The device is then removed and the severed native valve is recovered.
- said elongate support member is a tubular catheter. This catheter thus allows the flow of blood through it the time of the excision of the native valve.
- the section of the conduit of this catheter may be sufficient to allow the flow of blood through this conduit, which limits or avoids the need to put the patient into extracorporeal circulation.
- the catheter can also have a reduced diameter, which facilitates the introduction and the sliding of the device in the body conduit, but it is then necessary to ensure the peripheral circulation by an external assistance system, such as a delivery system. extra-corporeal circulation.
- the catheter has a lateral distal opening to allow blood to reach the body conduit, for example the ascending aorta, this opening being arranged so that the length of catheter through which the blood passes is as short as possible.
- the device comprises a distal inflatable balloon, placed at the level of the external face of said elongated element; this balloon is shaped so as to be able to occupy a folding position, in which it has a section such that it does not prevent the device from sliding into said body duct, and an unfolding position, in which it occupies the 'the whole of the space existing between the outer face of said elongated element and the wall of said body duct and comes, by a peripheral edge which it comprises, to bear against this wall.
- the balloon is inflated after positioning the series of blades on either side of the native valve, to prevent backflow of blood during the ablation of the native valve.
- said elongated element is a catheter, this balloon also makes it possible to cause this blood to flow only through the catheter.
- the device comprises a distal filter made of flexible material, placed at the level of the external face of said elongated element; this filter is shaped to be able to occupy a folding position, in which it has a section such that it does not prevent the introduction and sliding of the device in said body duct, and an unfolding position, in which it occupies the 'all of the space existing between the outer face of said elongated element and the wall of this conduit and comes, by a peripheral edge which it comprises, abuts against this wall.
- This filter makes it possible to capture any fragments generated by the excision of the valve, and to retain them so that they are removed from the blood circulation.
- the device may include means making it possible to move said series of blades in the axial direction independently of said balloon and / or said filter. Once deployed, this or these need not be moved axially in the body duct during the above-mentioned axial displacement of the series of blades.
- Said balloon and / or said filter can also be separated from the device, by being mounted on an elongate support element which is specific to them.
- this balloon and / or this filter are introduced into the aorta by peripheral arterial route, and the device is meanwhile introduced into the heart by the peripheral venous system, up to the right atrium then in the left atrium through the interatrial septum, up to the level of the mitral valve.
- the prosthetic valve can advantageously comprise an armature made of shape memory material, in particular of nickel-titanium alloy known under the name "NITINOL".
- valves made of biological material preserved animal or human valves
- valves made of synthetic material such as polymer
- Figure 1 is a longitudinal sectional view, according to a first embodiment for the treatment of an aortic valve;
- Figure 2 is a cross-sectional view along the line II-II of Figure 1;
- Figure 3 is a view similar to Figure 2, in another position of a sub-assembly which it comprises;
- Figure 4 is a perspective view of a prosthetic valve which it allows the establishment;
- Figures 5 to 9 are views while it is positioned in a heart, at the valve to be treated, during different successive operations by which this valve is cut and the prosthetic valve shown in Figure 4 is put in place ;
- Figure 10 is a view of the prosthetic valve shown in Figure 4, after installation, and
- Figure 1 1 is a view of the device according to another embodiment, for the treatment of a mitral valve.
- Figures 1 to 3 show a device 1 for replacing a heart valve percutaneously.
- This device comprises a tubular catheter 2 formed by three tubes 5, 6, 7 engaged one inside the other on which are placed, from the proximal side to the distal side (considered with respect to the flow of blood, i.e. say from right to left of FIG. 1), a prosthetic valve 10, two sets of blades 11, 12, a balloon 13 and a filter 14.
- the three tubes 5, 6, 7 are slidably mounted one inside the other.
- the inner tube 5 defines a conduit 15 whose cross section is sufficient to allow the flow of blood through it.
- the intermediate tube 6 forms a tulip 6a delimiting, with the inner tube 5, an annular cavity 17 in which the prosthetic valve 10 is contained in the folded state.
- FIG. 4 shows that this valve 10 comprises a frame 20 and valves 21 mounted in a functionally mobile manner on this frame 20.
- the frame is formed by assembling wires 22, 23, 24 of shape memory material, in particular of nickel-titanium alloy known under the name "NITINOL", namely: - a wire 22 of proximal end, presenting 'deployed state of the valve 10 a substantially circular shape; a wire 23 at the distal end forming three corrugations in the axial direction, these corrugations being regularly distributed over the circumference of the valve 10, and
- NITINOL nickel-titanium alloy known under the name
- the valves 21, for their part, are made of biological material (preserved animal or human valves), or of synthetic material, such as a polymer.
- the armature 20 can, when its material is cooled, be contracted radially so that the valve 10 can enter the cavity 1 7. When this material is warmed to body temperature, this armature 20 regains its shape d 'origin, shown in Figure 4, in which it has a diameter adapted to that of the body conduit, in particular the aorta, in which is the native valve to be treated. This diameter of the frame 20 is such that the valve 10 bears against the wall of the body duct and is immobilized in the axial direction relative to the latter.
- Each series of blades 1 1, 1 2 comprises elongated metal blades 30 and an inflatable balloon 31 situated between the catheter 2 and these blades 30.
- the blades 30 have a curved profile and are arranged around the circumference of the catheter 2.
- the blades 30 of the proximal series 1 1 are pivotally connected to the tube 6 by their proximal ends and include a sharp distal edge 30a, while the blades 30 of the distal series 1 2 are pivotally connected to the outer tube 7 by their distal ends and include a sharp proximal edge 30b.
- connection of the blades 30 to the tubes 6 and 7 respectively is carried out by welding the ends of the blades 30 together so as to form a ring, this ring being fixed axially to the tube 6, 7 corresponding by crimping this ring on this tube 6 , 7, the pivoting of the blades 30 being achieved by simple elastic deformation of these blades 30.
- This pivoting is possible between a folding position of the blades 30, radially internal relative to the catheter 2, shown in Figures 1 and 2, and an unfolding position of these blades 30, radially external with respect to this catheter 2, shown in Figure 3.
- the blades 30 are located near the wall of the tube 6 and are partially overlap each other so that they do not prevent the introduction and sliding of the device 1 in the body conduit in which the native valve to be treated is located; in said unfolding position, the blades 30 are deployed in a corolla such that their sharp edges 30a, 30b are placed in the extension of each other and thus constitute a sharp circular edge, visible in FIG. 3.
- Each balloon 31, placed between the tube 6 and the blades 30, can be inflated from the end of the catheter 2 which leaves the patient, by a conduit 32 arranged in the tube 6. It thus makes it possible, when inflated, to 'bring the blades 30 from their folding position to their unfolding position, and vice versa when it is deflated.
- the axial sliding of the tube 6 relative to the tube 7 makes it possible to move the series of blades 1 1, 1 2 axially in the direction of one another, between positions of mutual separation, shown in FIG. 1, and mutual ruzement.
- a series of blades 1 1 can be placed axially on one side of the native valve while the other series of blades 1 2 is placed axially on the other side of this valve, while in the second of these positions, the sharp circular edges of these two series of blades 1 1, 1 2 are brought into mutual contact and thus cut the native valve so as to separate it from said body conduit.
- the tubes 5 to 7 also include marks (not visible in the figures) with barium sulphate, allowing the percutaneous identification of the axial position of the device 1 relative to the native valve, so that each of the two series of blades 1 1, 1 2 can be placed on an axial side of this valve.
- These tubes 5 to 7 also include lateral distal openings (not shown) to allow blood to reach the body duct, these openings being arranged so that the length of catheter 2 through which the blood passes is as short as possible, c that is to say immediately afterwards, in the distal direction, the filter 14.
- the balloon 1 3 is placed on the outer face of the tube 7, distally with respect to the series 1 2.
- This balloon 1 3 has an annular shape and is shaped to be able to occupy a folding position in which it has a section such that it does not prevent the introduction and sliding of the device 1 in said body duct, and an unfolding position, in which it occupies all of the space existing between the outer face of the tube 7 and the wall of said duct body and comes, by a peripheral edge 1 3a which it comprises, to bear against this wall.
- the filter 14 is placed distally of the balloon 1 3, on the tube 7, to which it is fixed axially.
- This filter 14 is made of flexible material, for example polyester mesh, and is shaped to be able to occupy a folding position in which it has a section such that it does not prevent the introduction and sliding of the device 1 in said body duct, and an unfolding position in which it occupies all of the space existing between the outer face of the catheter 2 and the wall of this duct and comes, by a peripheral edge 14a which it comprises, abuts against this wall.
- An inflatable balloon 35 is placed between the tube 7 and the filter 14 in order, depending on whether it is inflated or deflated, to bring the filter 14 into its respective unfolding and folding positions.
- aorta 2 is located in the heart, preferably in the left ventricle, while the aforementioned distal lateral openings are placed in a peripheral arterial vessel, preferably in the ascending aorta.
- the balloons 1 3 and 35 are inflated so as to cause the blood to flow only through the conduit 1 5 and to prevent the back flow of blood during the ablation of the valve 55.
- a peripheral perfusion system is put in place. place to facilitate this flow.
- the blades 30 of the two series 1 1, 1 2 are then deployed
- the blades 30 are then brought back to the folding position by deflating the balloons 31 while remaining in their approximation position, which keeps the valve 55 cut between them.
- the device 1 is then slid axially in the distal direction in order to bring the tulip 6a to the appropriate level in the conduit 50 (FIG. 8), after which the valve 10 is deployed by sliding the tube 6 relative to the tube 5 (FIG. 9) ).
- the balloons 1 3 and 35 are deflated, then the device 1 is removed and the severed valve 55 is recovered (FIG. 10).
- Figure 1 1 shows a second embodiment of the device 1, allowing intervention on a mitral valve 56.
- the same reference numbers are used to designate the same elements or parts as above, since these elements or parts are identical or similar between the two embodiments.
- the tubular catheter is replaced by a support wire 2, on which one of the series of blades is mounted and by a tube engaged and able to slide on this wire, on which the other of the series of blades is mounted.
- the inflation conduits of the balloons 31 run along these support wires and tubes
- the balloon 1 3 and the filter 14 are separated from the device 1 and are introduced into the aorta by peripheral arterial route, by means of a support wire 40, along which the inflation ducts of the balloons 1 3 and 35 pass.
- the device 1, devoid of balloon 13 and filter 14 is meanwhile introduced into the heart by the peripheral venous system, up to the right atrium and then into the left atrium through the interatrial septum, up to at valve 56.
- the device 1 For the rest, the device 1 operates in the same manner as above.
- the invention thus provides a device for replacing a heart valve by percutaneous route, making it possible to remedy the drawbacks of the prior techniques.
- the device 1 gives all satisfaction with regard to the excision of the valve 55, 56, by making it possible to intervene without cardiac arrest and to prevent, thanks to the filter 14, any diffusion into the circulatory system of fragments of the valve 55, 56.
- the device can comprise a fourth tube, engaged and able to slide on the tube 7, this fourth tube comprising the balloon and the filter mounted on it and making it possible to move said series of blades in the axial direction independently of said balloon and / or said filter;
- the blades can be rectilinear as shown in the drawing or be curved towards the axis of the device at their end including the cutting edge, so as to eliminate any risk of injury to the wall of the body duct, as shown in Figure 1 2 ;
- the filter 14 can be of the self-expanding type and can normally be held in the retracted position by a sliding tube, which covers it, which makes the balloon 35 unnecessary.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9914462 | 1999-11-17 | ||
FR9914462A FR2800984B1 (en) | 1999-11-17 | 1999-11-17 | DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY |
PCT/FR2000/003176 WO2001035870A1 (en) | 1999-11-17 | 2000-11-15 | Device for replacing a cardiac valve by percutaneous route |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1233731A1 true EP1233731A1 (en) | 2002-08-28 |
EP1233731B1 EP1233731B1 (en) | 2004-12-29 |
Family
ID=9552220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00979740A Expired - Lifetime EP1233731B1 (en) | 1999-11-17 | 2000-11-15 | Device for replacing a cardiac valve by percutaneous route |
Country Status (10)
Country | Link |
---|---|
US (1) | US6830584B1 (en) |
EP (1) | EP1233731B1 (en) |
JP (1) | JP2003513751A (en) |
AT (1) | ATE285729T1 (en) |
AU (1) | AU767710B2 (en) |
CA (1) | CA2389713C (en) |
DE (1) | DE60017189T2 (en) |
ES (1) | ES2233482T3 (en) |
FR (1) | FR2800984B1 (en) |
WO (1) | WO2001035870A1 (en) |
Cited By (20)
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US9750607B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US9750605B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US9889002B2 (en) | 2001-08-03 | 2018-02-13 | Jenavalve Technology, Inc. | Devices useful for implantation at a heart valve |
US10245141B2 (en) | 2014-05-14 | 2019-04-02 | Sorin Group Italia S.R.L. | Implant device and implantation kit |
US10307251B2 (en) | 2010-05-20 | 2019-06-04 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable stent into the body of a patient |
US10363134B2 (en) | 2005-10-28 | 2019-07-30 | Jenavalve Technology, Inc. | Device for the implantation and fixation of prosthetic valves |
US10433954B2 (en) | 2013-08-30 | 2019-10-08 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US10660750B2 (en) | 2012-04-19 | 2020-05-26 | Caisson Interventional, LLC | Heart valve assembly systems and methods |
US10736736B2 (en) | 2013-10-23 | 2020-08-11 | Caisson Interventional, LLC | Methods and systems for heart valve therapy |
US10939998B2 (en) | 2015-12-30 | 2021-03-09 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11051935B2 (en) | 2012-04-19 | 2021-07-06 | Caisson Interventional, LLC | Valve replacement systems and methods |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US11278406B2 (en) | 2010-05-20 | 2022-03-22 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
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- 2000-11-15 DE DE60017189T patent/DE60017189T2/en not_active Expired - Lifetime
- 2000-11-15 JP JP2001537666A patent/JP2003513751A/en active Pending
- 2000-11-15 US US10/130,355 patent/US6830584B1/en not_active Expired - Lifetime
- 2000-11-15 CA CA002389713A patent/CA2389713C/en not_active Expired - Fee Related
- 2000-11-15 EP EP00979740A patent/EP1233731B1/en not_active Expired - Lifetime
- 2000-11-15 AU AU17132/01A patent/AU767710B2/en not_active Ceased
Non-Patent Citations (1)
Title |
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See references of WO0135870A1 * |
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US9889002B2 (en) | 2001-08-03 | 2018-02-13 | Jenavalve Technology, Inc. | Devices useful for implantation at a heart valve |
US9949824B2 (en) | 2001-08-03 | 2018-04-24 | Jenavalve Technology, Inc. | Devices useful for implantation at a heart valve |
US11007052B2 (en) | 2001-08-03 | 2021-05-18 | Jenavalve Technology, Inc. | Devices useful for implantation at a heart valve |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US10363134B2 (en) | 2005-10-28 | 2019-07-30 | Jenavalve Technology, Inc. | Device for the implantation and fixation of prosthetic valves |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11154398B2 (en) | 2008-02-26 | 2021-10-26 | JenaValve Technology. Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10307251B2 (en) | 2010-05-20 | 2019-06-04 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable stent into the body of a patient |
US10856978B2 (en) | 2010-05-20 | 2020-12-08 | Jenavalve Technology, Inc. | Catheter system |
US11278406B2 (en) | 2010-05-20 | 2022-03-22 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US11051935B2 (en) | 2012-04-19 | 2021-07-06 | Caisson Interventional, LLC | Valve replacement systems and methods |
US10660750B2 (en) | 2012-04-19 | 2020-05-26 | Caisson Interventional, LLC | Heart valve assembly systems and methods |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US10433954B2 (en) | 2013-08-30 | 2019-10-08 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US10736736B2 (en) | 2013-10-23 | 2020-08-11 | Caisson Interventional, LLC | Methods and systems for heart valve therapy |
US10245141B2 (en) | 2014-05-14 | 2019-04-02 | Sorin Group Italia S.R.L. | Implant device and implantation kit |
US9750607B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US10603167B2 (en) | 2014-10-23 | 2020-03-31 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US9750606B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US9750605B2 (en) | 2014-10-23 | 2017-09-05 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US10939998B2 (en) | 2015-12-30 | 2021-03-09 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
Also Published As
Publication number | Publication date |
---|---|
FR2800984A1 (en) | 2001-05-18 |
EP1233731B1 (en) | 2004-12-29 |
WO2001035870A1 (en) | 2001-05-25 |
FR2800984B1 (en) | 2001-12-14 |
AU767710B2 (en) | 2003-11-20 |
CA2389713C (en) | 2008-09-02 |
AU1713201A (en) | 2001-05-30 |
DE60017189T2 (en) | 2005-09-22 |
ES2233482T3 (en) | 2005-06-16 |
CA2389713A1 (en) | 2001-05-25 |
DE60017189D1 (en) | 2005-02-03 |
US6830584B1 (en) | 2004-12-14 |
ATE285729T1 (en) | 2005-01-15 |
JP2003513751A (en) | 2003-04-15 |
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