EP1287404A4 - Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method - Google Patents
Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation methodInfo
- Publication number
- EP1287404A4 EP1287404A4 EP01932784A EP01932784A EP1287404A4 EP 1287404 A4 EP1287404 A4 EP 1287404A4 EP 01932784 A EP01932784 A EP 01932784A EP 01932784 A EP01932784 A EP 01932784A EP 1287404 A4 EP1287404 A4 EP 1287404A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- immobilizing oligonucleotides
- cycloaddition
- oligonucleotides employing
- bioconjugation
- employing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20156100P | 2000-05-01 | 2000-05-01 | |
US201561P | 2000-05-01 | ||
US26502001P | 2001-01-30 | 2001-01-30 | |
US265020P | 2001-01-30 | ||
PCT/US2001/013956 WO2001084234A1 (en) | 2000-05-01 | 2001-05-01 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1287404A1 EP1287404A1 (en) | 2003-03-05 |
EP1287404A4 true EP1287404A4 (en) | 2003-10-15 |
Family
ID=26896865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01932784A Withdrawn EP1287404A4 (en) | 2000-05-01 | 2001-05-01 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1287404A4 (en) |
JP (1) | JP2003535317A (en) |
AU (1) | AU2001259285A1 (en) |
WO (1) | WO2001084234A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
US6664061B2 (en) | 1999-06-25 | 2003-12-16 | Amersham Biosciences Ab | Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
WO2002012566A2 (en) * | 2000-08-09 | 2002-02-14 | Motorola, Inc. | The use and evaluation of a [2+2] photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix |
WO2003062452A2 (en) | 2002-01-23 | 2003-07-31 | Proligo, Llc | Methods for the integrated synthesis and purification of oligonucleotides |
EP1585755B1 (en) | 2002-12-31 | 2015-08-05 | Sigma-Aldrich Co. LLC | Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support |
AU2004297228A1 (en) | 2003-12-03 | 2005-06-23 | Nektar Therapeutics Al, Corporation | Method of preparing maleimide functionalized polymers |
EP1697749B1 (en) * | 2003-12-22 | 2013-04-17 | Imec | The use of microelectronic structures for patterned deposition of molecules onto surfaces |
JPWO2005085857A1 (en) * | 2004-03-05 | 2008-01-24 | 日清紡績株式会社 | Method for detecting immobilized biomolecules and substances that can interact with biomolecules |
JP4581571B2 (en) * | 2004-09-06 | 2010-11-17 | 富士ゼロックス株式会社 | Quantitative method for measuring the amount of maleimidyl groups in particles |
CN101268118B (en) | 2005-07-19 | 2012-09-19 | 尼克塔治疗公司 | Method for preparing polymer maleimides |
GB0619182D0 (en) * | 2006-09-29 | 2006-11-08 | Leuven K U Res & Dev | Oligonucleotide arrays |
KR101637213B1 (en) * | 2008-12-02 | 2016-07-07 | 와코 쥰야꾸 고교 가부시키가이샤 | Photobase generator |
EP2852667A4 (en) * | 2012-05-21 | 2016-01-20 | Agilent Technologies Inc | Retro diels alder reaction as a cleavable linker in dna/rna applications |
JP5986872B2 (en) * | 2012-10-05 | 2016-09-06 | 公益財団法人微生物化学研究会 | Compound, method for producing compound, method for producing acetate derivative, method for producing atorvastatin, and method for recovering asymmetric ligand |
WO2015002813A1 (en) | 2013-07-01 | 2015-01-08 | Illumina, Inc. | Catalyst-free surface functionalization and polymer grafting |
WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
CN108911941A (en) * | 2018-05-25 | 2018-11-30 | 凯莱英生命科学技术(天津)有限公司 | 1,3- cyclohexadiene is continuously synthesizing to method |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998047910A1 (en) * | 1997-04-21 | 1998-10-29 | Proligo Llc | Method for solution phase synthesis of oligonucleotides |
US6171797B1 (en) * | 1999-10-20 | 2001-01-09 | Agilent Technologies Inc. | Methods of making polymeric arrays |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6231794A (en) * | 1993-01-21 | 1994-08-15 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon, The | Chemical functionalization of surfaces |
US6737236B1 (en) * | 1997-01-08 | 2004-05-18 | Proligo, Llc | Bioconjugation of macromolecules |
-
2001
- 2001-05-01 EP EP01932784A patent/EP1287404A4/en not_active Withdrawn
- 2001-05-01 AU AU2001259285A patent/AU2001259285A1/en not_active Abandoned
- 2001-05-01 JP JP2001580595A patent/JP2003535317A/en not_active Ceased
- 2001-05-01 WO PCT/US2001/013956 patent/WO2001084234A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998047910A1 (en) * | 1997-04-21 | 1998-10-29 | Proligo Llc | Method for solution phase synthesis of oligonucleotides |
US6171797B1 (en) * | 1999-10-20 | 2001-01-09 | Agilent Technologies Inc. | Methods of making polymeric arrays |
Non-Patent Citations (1)
Title |
---|
See also references of WO0184234A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001084234A1 (en) | 2001-11-08 |
EP1287404A1 (en) | 2003-03-05 |
AU2001259285A1 (en) | 2001-11-12 |
JP2003535317A (en) | 2003-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20021129 |
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AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 07H 21/00 B Ipc: 7C 07F 9/24 B Ipc: 7C 07F 7/18 B Ipc: 7C 07D 207/46 B Ipc: 7C 07C 271/16 B Ipc: 7C 07C 215/10 B Ipc: 7C 07B 61/00 B Ipc: 7C 07H 19/04 B Ipc: 7C 07H 19/00 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030827 |
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17Q | First examination report despatched |
Effective date: 20040114 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20040525 |