EP1287804A2 - Device for bringing components together in sterile conditions - Google Patents

Device for bringing components together in sterile conditions Download PDF

Info

Publication number
EP1287804A2
EP1287804A2 EP20020017985 EP02017985A EP1287804A2 EP 1287804 A2 EP1287804 A2 EP 1287804A2 EP 20020017985 EP20020017985 EP 20020017985 EP 02017985 A EP02017985 A EP 02017985A EP 1287804 A2 EP1287804 A2 EP 1287804A2
Authority
EP
European Patent Office
Prior art keywords
hollow body
container
cannula
closure
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20020017985
Other languages
German (de)
French (fr)
Other versions
EP1287804A3 (en
EP1287804B1 (en
Inventor
Thomas Pfeifer
Dietmar Palm
Michael Becker
Michael Seipp
Rainer Wabnegg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring GmbH
Original Assignee
Aventis Behring GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Behring GmbH filed Critical Aventis Behring GmbH
Publication of EP1287804A2 publication Critical patent/EP1287804A2/en
Publication of EP1287804A3 publication Critical patent/EP1287804A3/en
Application granted granted Critical
Publication of EP1287804B1 publication Critical patent/EP1287804B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2055Connecting means having gripping means

Definitions

  • the invention relates to a device for merging a in a first Container received liquid component and one in a second container absorbed solid or liquid component under sterile conditions.
  • Such a preassemblable device is known from the prior art. It is a device for passing a solvent from a bottle in a second, pharmaceutical product containing bottle to the To solve the product.
  • a transfer system is called a disposable medical device classified.
  • the two glass bottles are preassembled in the transfer unit.
  • a sterile packaging ensures that the storage of the reconstituted product is up to 36 Hours can be done.
  • a device of the aforementioned type is described in EP 0 737 467 A1.
  • a two-step mechanism With Help of a two-step mechanism becomes a secured, directed transition achieved by first having the closure of the liquid component first container is pierced by means of a cannula and then a the Cannula receiving cannula carrier by means of this container in the direction of the moved solid or liquid component receiving the second container so that its closure is pierced by means of the cannula.
  • the cannula carrier picks up a single cannula used for merging the components is sufficient before the piercing of the second container in this vacuum prevails.
  • the cannula holder is plate-shaped, perpendicular to the longitudinal direction of the two containers receiving hollow body oriented body formed, which connected via retaining webs with the inner wall of the hollow body is, wherein the holding webs rupturable by applying a manual force are greater than the penetration force of the cannula when piercing the sealing plug of the initially opened container.
  • a device of the aforementioned Type to form so that an exact passing over the located in the first container Component is ensured in the second container.
  • the invention proposes according to the claims 1 and 2 two fundamental Arrangements of the device before.
  • the characteristics of the Having device according to the aforementioned type is a first cylindrical Hollow body for receiving the first container in the region of its closure in a receiving opening of this hollow body and a second cylindrical Hollow body for receiving the second container in the region of its closure provided in a diametrically arranged receiving opening.
  • the two hollow bodies inserted into each other and guided in the longitudinal direction relative to each other displaceable further is a cup-shaped unit with the first hollow body forming cannula carrier with at least one of this recorded cannula Mistake.
  • the first hollow body and the cannula carrier are thus not separable, they represent a permanent unit.
  • the cup-shaped design of the unit ensures that the unit, especially in the area of the first Hollow body, precisely guided in the second hollow body.
  • the pot wall should be at least a guide portion having at least one guide portion the second hollow body cooperates. Due to the precise guidance of the assembly due to its cup-shaped design in the second hollow body is ensured that the assembly and thus the cannula carrier does not tip over.
  • the cannula In a sliding movement of the cannula holder, the cannula is defined in the longitudinal direction the two hollow body by the displacement by means of the first container in Direction of the second container moves and pierces the shutter.
  • the cannula holder takes the cannula firmly, so they do not in their Is longitudinally displaceable.
  • the cannula carrier is used taken only a cannula, wherein there is a vacuum in the second container. After moving the first container in the direction of the second container and piercing the closure of the first container by means of the cannula and the further advancement of the first container and piercing the shutter passes the liquid component located in the first container due to the vacuum in the second container and mixes with the there solid or liquid component under sterile conditions.
  • the cannula carrier and the cannula may form two separate components, the cannula carrier in particular made of plastic and the cannula consists in particular of metal. It is but quite conceivable, the cannula carrier and the cannula in one piece, wherein the cannula is formed in the manner of a spike. Preferably this unit is made of plastic. The spike / spike points accordingly Conditions one or two passes on. Located in the second bottle Vacuum, one passage is enough.
  • the first Hollow body and the cannula carrier no assembly.
  • the cannula carrier to ensure precise guidance when moving it, cup-shaped executed.
  • the first hollow body serves to receive the first container, while the cannula support the storage of the cannula and its precise guidance serves in the longitudinal direction of the two hollow body.
  • the pot wall should have at least one guide section, which cooperates with at least one guide portion of the first hollow body.
  • the first hollow body is inserted in this first container stored immovably in the second hollow body. Is the first container in used the first hollow body, takes place during advancement of the first container only a feeding of the cup-shaped cannula holder.
  • the first hollow body forming a structural unit with the cannula carrier or the cup-shaped cannula carrier locking means for locking in different Positions of the cannula holder in complementary locking means of the second hollow body.
  • These locking means provide a defined displacement of the Cannula carrier and thus the cannula safely.
  • the puncture resistance of the closure the second container to choose greater than that of the closure of the first container, so that the closure of the second container the resistance with respect to the cannula, the advancing of the first container causes its closure to be punctured. In this case, that would be aforementioned detent not required.
  • the second detent serves to fix the cannula holder or one with this connected components in the maximum advanced position. She poses sure that when removing the second container from the second hollow body the cannula support is not retightened and therefore the cannula from the Closure of the second container is pulled.
  • Essential aspects of the device according to the invention are thus in the Handling safety and robustness in the application through a new design of the cannula holder, which is no longer fixed to a cylindrical hollow body connected and no longer run as a disc.
  • the design as a "pot” allows a much more guided movement in activation after the Principle "piston in the cylinder".
  • the activation of the device takes place in vertically oriented position by pressure on the top of the first container.
  • the first and / or second hollow body in the region of its container side End formed segment-shaped.
  • This allows the respective container to fix precisely in the associated hollow body, but the container relative to move to the hollow body, wherein the segments are spread outwards.
  • the segments form in particular spreading tabs which form a crimp cap of the embrace the respective container.
  • the device is particularly related with containers designed as vials. It are preferably glass vials with a filling volume of 1 to 10 ml.
  • the device has a visual endpoint indication, in which through viewing window reaching the end position of the cannula holder and thus the piercing of the closure of the second container by means of the cannula can be reconstructed.
  • the second hollow body is this side with the or provided the viewing windows.
  • the device For immediate use is the device, that is with the two in the Hollow pre-assembled containers in a package, in particular a Soft pleated packaging, sealed. It thus exists during the reconstitution procedure no danger of microbiological contamination, since the fürleitvorgang within the sterile outer packaging, and moreover allows storage of the reconstituted product under sterile conditions.
  • the device according to the invention also prevents the handling of Cannulas with freely accessible cannula tips. There is no risk of injury during removal of the product bottle after reconstitution, because the cannula carrier is retained in the device.
  • the device is because of the Pre-assembly of the relevant components immediately available. In a short time the liquid can be transferred from the first to the second container. This requires a considerable time savings during the preparation process. Reconstitution can be prepared by a single person either before or take place directly in the sterile area of an operating room.
  • Figures 1 and 2 illustrate the device according to the invention, also as Transfer system 1, in a three-part embodiment.
  • a first hollow body 2 serves for the displaceable reception of a cup-shaped cannula carrier 3 and can be inserted into the second hollow body 4.
  • the hollow body 2 serves as a holder for a solvent bottle and is for this purpose with various parallel to the longitudinal axis of the cylindrical hollow body 2 arranged flexible Segments 5 provided. These carry inward beads 6.
  • the Opening 7 of the hollow body 2, which is at the top during use of the transfer system, serves to accommodate the solvent bottle.
  • the hollow body 2 In the region of the lower opening 8 is the hollow body 2 with an inner guide portion 9 for the picked up by this Cannula carrier 3 provided, which has an outer complementary guide surface 10, so that the cannula carrier 3 with a small clearance in the hollow body. 2 is guided.
  • the cup-shaped cannula carrier 3 takes in the region of its bottom portion 11 fixed a central, axially directed transfer cannula 12, which is provided with pointed ends is.
  • the length of the transfer cannula 12 is dimensioned such that their respective Supernatants, based on the bottom portion 1 of the cannula holder 3, sufficient to the closures of the cooperating with the device containers pierce.
  • the second hollow body 4 serves to receive the first hollow body 2 and the cannula carrier 3 in its advanced position. That on the position of use of Device related lower end of the hollow body 4 is according to the design of the hollow body 2 is provided with flexible segments 13, which in turn after have internally directed beads 14. By the these segments 13 associated Opening 15 of the hollow body 4, the second container, the solid or liquid component receives, inserted into the hollow body 4. Around other opening 16, the hollow body 4 is extended, so that when inserted in this Hollow body 2 whose flexible segments have enough space to to be spread outwards.
  • the hollow body 2 is held in the hollow body 4 in the region of its lower, outer guide portion 17, with a circumferential Locking groove 18 is provided, in which in the region of the complementary inner Guide portion 19 a local circumferential locking projection 20 engages. In inserted position of the hollow body 2, this is thus with respect to the hollow body 4 fixed.
  • the cannula carrier 3 has in the region of its outer guide portion 10th a circumferential locking projection 21, in the largely from the bottom opening 11 remote position cooperates with an extension 22 in the hollow body 4. If the cannula carrier 3 by applying a in the direction of the opening 15th directed to directed force, the cannula carrier 3 is advanced until the Detent projection 21 with a further located in the front of the hollow body 4 locking groove 23rd the hollow body 4 rests. In this position, the cannula carrier 3 is with his Bottom portion 11 to a circumferential annular projection 24 of the hollow body 4 at.
  • Figure 1 illustrates the mounting state of the transfer system 1 in the Hollow body 4 inserted hollow body 2, before advancing the cannula holder 3 in the direction of the opening 15 in the hollow body 4th
  • FIG. 3 shows the different steps during assembly and activation of the transfer system 1.
  • step a the item view according to FIG 2 illustrates, further provided for insertion into the hollow body 2 Glass bottle 25, which takes up the solvent.
  • the bottle 25 is equipped with an elastic, pierceable closure 26 is provided and has in the region of the closure a crimp cap 27 on.
  • the other, the fixed or liquid component receiving glass bottle 28 designed from below in the Hollow body 4 can be used.
  • the glass bottle 25 inserted into the hollow body 2 and the glass bottle 28 in the hollow body 4. Underline this, as to c.
  • FIGS. 4 and 5 differs from that according to Figures 1 and 2, characterized in that instead of the two components - hollow body. 2 and cannula support 3 - a component 29 is provided, the function of these two Components united in one another.
  • FIGS. 1 and 2 as well as the functional representation according to Figure 3 matching components are in Figures 4 and 5 and the functional representation of Figure 6 simplicity half the same reference numerals.
  • the structural unit 29 is cup-shaped and is formed by the cylindrical hollow body 2 and the cannula carrier 3 formed.
  • the assembly 29 is provided with an outer circumferential locking projection 30 provided, whose function is that of the locking projection 21 on the cannula carrier 3 in the embodiment according to Figures 1 and 2 corresponds.
  • the outer guide portion 31 of the assembly 29 interacts with the inner guide portion 32 of the hollow body 4 together, in the two functional positions the cannula support 3 of the assembly 29 is provided with inner locking grooves 33 and 34, respectively is that in their function of the extension 22 and the locking groove 23 of the hollow body 2 in the embodiment described above.
  • Figure 6 illustrates; in this position, the locking projection 30 of the unit 29 reaches the locking groove 34 of the hollow body 4 and the cannula 12 has the closure 26 of the lower bottle 28 pierced.
  • the removal situation of this Bottle is too f. illustrated in FIG.
  • FIGs 7A to 7D illustrate a shrink-wrapped in a blister sheet Transfer system 1 with the bottles used in this 25 and 28, in one Condition, as shown in Figures 3 and 6 to the stage c. is illustrated.
  • the Blister foil 37 is welded to a sealing paper 38, preferably for a Sterilization agent is consistent.
  • FIG. 7A shows the arrangement in a plan view
  • FIG. 7B shows this in a side view
  • FIGS. 7C and 7D show sections along the lines A-A and B-B in FIG 7A

Abstract

An arrangement for collecting liquid components in a primary container, and solid or liquid components in a secondary container, under sterile conditions, comprises a primary cylindrical hollow member (2) for holding the primary container (25) over its closure area. An arrangement for collecting liquid components in a primary container, and solid or liquid components in a secondary container, under sterile conditions, comprises a primary cylindrical hollow member (2) for holding the primary container (25) over its closure area. A secondary cylindrical hollow member (4) holds the secondary container. One container is located inside the other, and they can be moved longitudinally with respect to each other. Tube carriers form the base of the pot and the primary hollow member wall.

Description

Die Erfindung betrifft eine Vorrichtung zum Zusammenführen einer in einem ersten Behältnis aufgenommenen flüssigen Komponente und einer in einem zweiten Behältnis aufgenommenen festen oder flüssigen Komponente unter sterilen Bedingungen.The invention relates to a device for merging a in a first Container received liquid component and one in a second container absorbed solid or liquid component under sterile conditions.

Eine derartige, vormontierbare Vorrichtung ist aus dem Stand der Technik bekannt. Es handelt sich um ein Gerät zum Überleiten eines Lösungsmittels von einer Flasche in eine zweite, ein pharmazeutisches Produkt enthaltende Flasche, um das Produkt zu lösen. Ein solches Überleit-System wird als medizinischer Einmalartikel eingestuft. Um die Handhabung des Rekonstitutionsprozesses zu vereinfachen, werden die beiden Glasflaschen in das Überleitgerät vormontiert. Eine sterile Verpackung gewährleistet, dass die Lagerung des rekonstituierten Produktes bis zu 36 Stunden erfolgen kann.Such a preassemblable device is known from the prior art. It is a device for passing a solvent from a bottle in a second, pharmaceutical product containing bottle to the To solve the product. Such a transfer system is called a disposable medical device classified. To simplify the handling of the reconstitution process, the two glass bottles are preassembled in the transfer unit. A sterile packaging ensures that the storage of the reconstituted product is up to 36 Hours can be done.

Eine Vorrichtung der eingangs genannten Art ist in der EP 0 737 467 A1 beschrieben. Dort dient ein einziger Hohlkörper der Aufnahme der beiden Behältnisse. Mit Hilfe eines Zweischrittmechanismus wird eine gesicherte, gerichtete Überleitung erreicht, indem zunächst der Verschluss des die flüssige Komponente aufweisenden ersten Behältnisses mittels einer Kanüle durchstochen wird und dann ein die Kanüle aufnehmender Kanülenträger mittels diesem Behältnis in Richtung des die feste oder flüssige Komponente aufnehmenden zweiten Behältnisses verschoben wird, so dass deren Verschluss mittels der Kanüle durchstochen wird. Der Kanülenträger nimmt eine einzige Kanüle auf, die für das Zusammenführen der Komponenten ausreicht, da vor dem Anstechen des zweiten Behältnisses in diesem Vakuum herrscht. Der Kanülenträger ist als plattenförmiger, senkrecht zur Längsrichtung des die beiden Behältnisse aufnehmenden Hohlkörpers orientierter Körper ausgebildet, der über Haltestege mit der Innenwandung des Hohlkörpers verbunden ist, wobei die Haltestege durch Aufbringen einer manuellen Kraft zerreißbar sind, die größer ist als die Durchdringkraft der Kanüle beim Durchstechen des Verschlussstopfens des zunächst geöffneten Behältnisses.A device of the aforementioned type is described in EP 0 737 467 A1. There is a single hollow body receiving the two containers. With Help of a two-step mechanism becomes a secured, directed transition achieved by first having the closure of the liquid component first container is pierced by means of a cannula and then a the Cannula receiving cannula carrier by means of this container in the direction of the moved solid or liquid component receiving the second container so that its closure is pierced by means of the cannula. The cannula carrier picks up a single cannula used for merging the components is sufficient before the piercing of the second container in this vacuum prevails. The cannula holder is plate-shaped, perpendicular to the longitudinal direction of the two containers receiving hollow body oriented body formed, which connected via retaining webs with the inner wall of the hollow body is, wherein the holding webs rupturable by applying a manual force are greater than the penetration force of the cannula when piercing the sealing plug of the initially opened container.

Nachteilig ist bei dieser Vorrichtung, dass der zunächst fest mit dem Hohlkörper verbundene Kanülenträger nicht definiert vom Hohlkörper getrennt wird. Je nach der Art der Krafteinleitung, gegebenenfalls einer unsymmetrischen Krafteinleitung, reißen zunächst Haltestege in einem Bereich des Kanülenträgers, womit die Gefahr besteht, dass der Kanülenträger und damit die Kanüle in eine bezüglich der Längsrichtung der beiden Behältnisse gekippte Position schwenken. Die Folge ist, dass insbesondere der Verschluss des zweiten Behältnisses nicht exakt durchstochen wird und sich Probleme beim Überleiten der Flüssigkeit, insbesondere unter dem Aspekt des anliegenden Vakuums ergeben.The disadvantage of this device that the first fixed to the hollow body Connected cannula carrier is not defined separated from the hollow body. Depending on the type of force application, if necessary, an asymmetrical force application, First tear holding webs in an area of the cannula carrier, bringing the danger consists in that the cannula carrier and thus the cannula in a respect to the longitudinal direction swivel the tilted position of the two containers. The consequence is that in particular, the closure of the second container is not exactly punctured will and problems in passing the liquid, especially under the Aspect of the applied vacuum.

Es ist Aufgabe der vorliegenden Erfindung, eine Vorrichtung der eingangs genannten Art so weiter zu bilden, dass ein exaktes Überleiten der im ersten Behältnis befindlichen Komponente in das zweite Behältnis gewährleistet ist.It is an object of the present invention, a device of the aforementioned Type to form so that an exact passing over the located in the first container Component is ensured in the second container.

Die Erfindung schlägt gemäß der Patentansprüche 1 und 2 zwei grundsätzliche Gestaltungen der Vorrichtung vor. Bei beiden Vorrichtungen, die die Merkmale der Vorrichtung gemäß der eingangs genannten Art aufweisen, ist ein erster zylindrischer Hohlkörper zur Aufnahme des ersten Behältnisses im Bereich dessen Verschlusses in einer Aufnahmeöffnung dieses Hohlkörpers und ein zweiter zylindrischer Hohlkörper zur Aufnahme des zweiten Behältnisses im Bereich dessen Verschlusses in einer diametral angeordneten Aufnahmeöffnung vorgesehen. The invention proposes according to the claims 1 and 2 two fundamental Arrangements of the device before. In both devices, the characteristics of the Having device according to the aforementioned type, is a first cylindrical Hollow body for receiving the first container in the region of its closure in a receiving opening of this hollow body and a second cylindrical Hollow body for receiving the second container in the region of its closure provided in a diametrically arranged receiving opening.

Allerdings sind bei der Vorrichtung gemäß der ersten Gestaltung die beiden Hohlkörper ineinander gesteckt und in deren Längsrichtung geführt relativ zueinander verschiebbar, ferner ist ein eine topfförmige Baueinheit mit dem ersten Hohlkörper bildender Kanülenträger mit mindestens einer von diesem aufgenommenen Kanüle versehen. Der erste Hohlkörper und der Kanülenträger sind somit nicht trennbar, sie stellen eine dauerhafte Baueinheit dar. Die topfförmige Gestaltung der Baueinheit stellt sicher, dass die Baueinheit, insbesondere in deren Bereich des ersten Hohlkörpers, präzise im zweiten Hohlkörper geführt ist. Vorzugsweise bildet der Kanülenträger den Boden des Topfes und der erste Hohlkörper die Topfwandung, womit der erste Hohlkörper nicht über den Kanülenträger hinaus verlängert ist. Um eine sehr genaue Führung zu gewährleisten, sollte die Topfwandung mindestens einen Führungsabschnitt aufweisen, der mit mindestens einem Führungsabschnitt des zweiten Hohlkörpers zusammenwirkt. Durch die präzise Führung der Baueinheit aufgrund deren topfförmiger Gestaltung im zweiten Hohlkörper ist sichergestellt, dass die Baueinheit und damit der Kanülenträger nicht kippt. Bei einer Verschiebebewegung des Kanülenträgers wird die Kanüle definiert in Längsrichtung der beiden Hohlkörper durch das Verschieben mittels des ersten Behältnisses in Richtung des zweiten Behältnisses bewegt und durchsticht dessen Verschluss.However, in the device according to the first embodiment, the two hollow bodies inserted into each other and guided in the longitudinal direction relative to each other displaceable, further is a cup-shaped unit with the first hollow body forming cannula carrier with at least one of this recorded cannula Mistake. The first hollow body and the cannula carrier are thus not separable, they represent a permanent unit. The cup-shaped design of the unit ensures that the unit, especially in the area of the first Hollow body, precisely guided in the second hollow body. Preferably, the forms Cannula holder the bottom of the pot and the first hollow body the pot wall, whereby the first hollow body is not extended beyond the cannula carrier out. Around To ensure a very accurate guidance, the pot wall should be at least a guide portion having at least one guide portion the second hollow body cooperates. Due to the precise guidance of the assembly due to its cup-shaped design in the second hollow body is ensured that the assembly and thus the cannula carrier does not tip over. In a sliding movement of the cannula holder, the cannula is defined in the longitudinal direction the two hollow body by the displacement by means of the first container in Direction of the second container moves and pierces the shutter.

In aller Regel nimmt der Kanülenträger die Kanüle fest auf, so dass sie nicht in deren Längsrichtung verschiebbar ist. Vorzugsweise wird von dem Kanülenträger auch nur eine Kanüle aufgenommen, wobei im zweiten Behältnis Vakuum herrscht. Nach dem Bewegen des ersten Behältnisses in Richtung des zweiten Behältnisses und dem Durchstechen des Verschlusses des ersten Behältnisses mittels der Kanüle sowie dem weiteren Vorschieben des ersten Behältnisses und Durchstechen des Verschlusses gelangt die in dem ersten Behältnis befindliche flüssige Komponente aufgrund des Vakuums in das zweite Behältnis und mischt sich mit der dort befindlichen festen oder flüssigen Komponente unter sterilen Bedingungen. As a rule, the cannula holder takes the cannula firmly, so they do not in their Is longitudinally displaceable. Preferably, the cannula carrier is used taken only a cannula, wherein there is a vacuum in the second container. After moving the first container in the direction of the second container and piercing the closure of the first container by means of the cannula and the further advancement of the first container and piercing the shutter passes the liquid component located in the first container due to the vacuum in the second container and mixes with the there solid or liquid component under sterile conditions.

Im Sinne der erfindungsgemäßen Lehre gemäß der beiden Gestaltungen sind die Begriffe "Kanülenträger" und "Kanüle" umfassend zu verstehen. Der Kanülenträger und die Kanüle können zwei separate Bauteile bilden, wobei der Kanülenträger insbesondere aus Kunststoff und die Kanüle insbesondere aus Metall besteht. Es ist aber durchaus denkbar, den Kanülenträger und die Kanüle einteilig zu gestalten, wobei die Kanüle in Art eines Dornes bzw. Spikes ausgebildet ist. Vorzugsweise besteht diese Baueinheit aus Kunststoff. Der Dorn/Spike weist entsprechend den Gegebenheiten ein oder zwei Durchgänge auf. Befindet sich in der zweiten Flasche Vakuum, reicht ein Durchgang aus.In the sense of teaching according to the invention according to the two designs are the To understand comprehensively terms "cannula holder" and "cannula". The cannula carrier and the cannula may form two separate components, the cannula carrier in particular made of plastic and the cannula consists in particular of metal. It is but quite conceivable, the cannula carrier and the cannula in one piece, wherein the cannula is formed in the manner of a spike. Preferably this unit is made of plastic. The spike / spike points accordingly Conditions one or two passes on. Located in the second bottle Vacuum, one passage is enough.

Bei der Vorrichtung gemäß der zweiten Gestaltung sind, im Unterschied zur ersten Gestaltung die beiden Hohlkörper ineinander gesteckt und es bilden der erste Hohlkörper und ein topfförmiger Kanülenträger mit mindestens einer von diesem aufgenommenen Kanüle separate Bauteile, wobei der erste Hohlkörper und der Kanülenträger ineinander gesteckt und in Längsrichtung der beiden Hohlkörper geführt relativ zueinander verschiebbar sind. Bei dieser Variante bilden der erste Hohlkörper und der Kanülenträger keine Baueinheit. Stattdessen ist der Kanülenträger, um die präzise Führung bei dessen Verschieben zu gewährleisten, topfförmig ausgeführt. Der erste Hohlkörper dient der Aufnahme des ersten Behältnisses, während der Kanülenträger der Lagerung der Kanüle und dessen präziser Führung in Längsrichtung der beiden Hohlkörper dient. Die Funktion der Lagerung des ersten Hohlkörpers und der Lagerung der Kanüle ist bei dieser Gestaltung somit auf zwei grundsätzliche Bauteile verlagert, im Gegensatz zu der ersten Lösung. Selbstverständlich kann, bei beiden Gestaltungen, der Kanülenträger durchaus der Aufnahme von mehr als einer Kanüle dienen, je nach dem Anwendungsfall.In the device according to the second embodiment, unlike the first Design the two hollow bodies inserted into each other and form the first Hollow body and a cup-shaped cannula carrier with at least one of this accommodated cannula separate components, wherein the first hollow body and the Cannula carrier inserted into each other and in the longitudinal direction of the two hollow body guided are displaced relative to each other. In this variant form the first Hollow body and the cannula carrier no assembly. Instead, the cannula carrier, to ensure precise guidance when moving it, cup-shaped executed. The first hollow body serves to receive the first container, while the cannula support the storage of the cannula and its precise guidance serves in the longitudinal direction of the two hollow body. The function of storage of the first Hollow body and the storage of the cannula is thus on in this design shifted two fundamental components, in contrast to the first solution. Of course can, in both designs, the cannula carrier quite recording serve more than one cannula, depending on the application.

Während bei der ersten Gestaltung der erste Hohlzylinder im Bereich des Kanülenträgers geschlossen ist, ist er bei der zweiten Gestaltung beidseitig offen. Bei dieser Gestaltung sollte die Topfwandung mindestens einen Führungsabschnitt aufweisen, der mit mindestens einem Führungsabschnitt des ersten Hohlkörpers zusammenwirkt. Zweckmäßig ist der erste Hohlkörper bei in diesen eingesetztem ersten Behältnis im zweiten Hohlkörper unverschieblich gelagert. Ist das erste Behältnis in den ersten Hohlkörper eingesetzt, erfolgt beim Vorschieben des ersten Behältnisses nur ein Vorschieben des topfförmigen Kanülenträgers.While in the first design of the first hollow cylinder in the region of the cannula holder is closed, it is open on both sides in the second design. At this Design, the pot wall should have at least one guide section, which cooperates with at least one guide portion of the first hollow body. Suitably, the first hollow body is inserted in this first container stored immovably in the second hollow body. Is the first container in used the first hollow body, takes place during advancement of the first container only a feeding of the cup-shaped cannula holder.

Zweckmäßig weist der mit dem Kanülenträger eine Baueinheit bildende erste Hohlkörper bzw. der topfförmige Kanülenträger Rastmittel zum Rastieren in unterschiedlichen Positionen des Kanülenträgers in komplementären Rastmitteln des zweiten Hohlkörpers auf. Diese Rastmittel stellen ein definiertes Verschieben des Kanülenträgers und damit der Kanüle sicher. Soll der Verschluss des ersten Behältnisses durchstochen werden, bevor der Kanülenträger vorgeschoben wird und bevor er in Kontakt mit dem Verschluss des zweiten Behältnisses gelangt, muss die Rastierung des Kanülenträgers in dieser Position so dimensioniert werden, dass er sich bei Kontakt des Verschlusses des ersten Behältnisses mit der Kanüle nicht verschiebt. Erst dann, wenn die Kanüle diesen Verschluss durchstochen hat, gelangt das erste Behältnis bzw. dessen Verschluss in Anlage zum Kanülenträger oder einem mit diesem verbundenen Bauteil, so dass beim Vorschieben des ersten Behältnisses der Kanülenträger durch die extern aufgebrachte Kraft verschoben wird. ― Grundsätzlich wäre es auch denkbar, die Durchstichfestigkeit des Verschlusses des zweiten Behältnisses größer zu wählen als die des Verschlusses des ersten Behältnisses, so dass der Verschluss des zweiten Behältnisses den Widerstand bezüglich der Kanüle aufbringt, der beim Vorschieben des ersten Behältnisses dazu führt, dass dessen Verschluss durchstochen wird. In diesem Fall wäre die vorgenannte Rastierung nicht erforderlich.Suitably, the first hollow body forming a structural unit with the cannula carrier or the cup-shaped cannula carrier locking means for locking in different Positions of the cannula holder in complementary locking means of the second hollow body. These locking means provide a defined displacement of the Cannula carrier and thus the cannula safely. Should the closure of the first container be pierced before the cannula carrier is advanced and before it comes in contact with the closure of the second container, the Rastierung of the cannula carrier in this position are dimensioned so that he not on contact of the closure of the first container with the cannula shifts. Only then, when the cannula has pierced this closure, passes the first container or its closure in contact with the cannula carrier or a component connected to it, so that when advancing the first Container of the cannula carrier displaced by the externally applied force becomes. - In principle, it would also be conceivable, the puncture resistance of the closure the second container to choose greater than that of the closure of the first container, so that the closure of the second container the resistance with respect to the cannula, the advancing of the first container causes its closure to be punctured. In this case, that would be aforementioned detent not required.

Die zweite Rastierung dient dem Fixieren des Kanülenträgers bzw. eines mit diesem verbundenen Bauteiles in der maximal vorgeschobenen Stellung. Sie stellt sicher, dass beim Entnehmen des zweiten Behältnisses aus dem zweiten Hohlkörper der Kanülenträger nicht nachgezogen wird und demzufolge die Kanüle aus dem Verschluss des zweiten Behältnisses gezogen wird. The second detent serves to fix the cannula holder or one with this connected components in the maximum advanced position. She poses sure that when removing the second container from the second hollow body the cannula support is not retightened and therefore the cannula from the Closure of the second container is pulled.

Wesentliche Aspekte der erfindungsgemäßen Vorrichtung liegen somit in der Handhabungssicherheit und Robustheit bei der Anwendung durch eine neue Konstruktion des Kanülenträgers, der nicht mehr fest mit einem zylindrischen Hohlkörper verbunden und nicht mehr als Scheibe ausgeführt ist. Die Gestaltung als "Topf" ermöglicht eine sehr viel stärker geführte Bewegung bei der Aktivierung nach dem Prinzip "Kolben im Zylinder". Bei Verwendung einer einzigen Kanüle und unter Vakuumbedingungen im zweiten Behältnis erfolgt die Aktivierung der Vorrichtung in senkrecht orientierter Position durch Druck auf das oben befindliche erste Behältnis.Essential aspects of the device according to the invention are thus in the Handling safety and robustness in the application through a new design of the cannula holder, which is no longer fixed to a cylindrical hollow body connected and no longer run as a disc. The design as a "pot" allows a much more guided movement in activation after the Principle "piston in the cylinder". When using a single cannula and under vacuum conditions in the second container, the activation of the device takes place in vertically oriented position by pressure on the top of the first container.

Vorzugweise ist der erste und/oder zweite Hohlkörper im Bereich seines behälterseitigen Endes segmentförmig ausgebildet. Dies ermöglicht es, den jeweiligen Behälter präzise im zugeordneten Hohlkörper zu fixieren, allerdings den Behälter relativ zum Hohlkörper zu bewegen, wobei die Segmente nach außen gespreizt werden. Die Segmente bilden insbesondere Spreizlappen, die eine Bördelkappe des jeweiligen Behältnisses umgreifen. Die Vorrichtung wird insbesondere im Zusammenhang mit Behältnissen, die als Fläschchen ausgebildet sind, verwendet. Es handelt sich vorzugsweise um Glasfläschchen mit einem Füllvolumen von 1 bis 10 ml.Preferably, the first and / or second hollow body in the region of its container side End formed segment-shaped. This allows the respective container to fix precisely in the associated hollow body, but the container relative to move to the hollow body, wherein the segments are spread outwards. The segments form in particular spreading tabs which form a crimp cap of the embrace the respective container. The device is particularly related with containers designed as vials. It are preferably glass vials with a filling volume of 1 to 10 ml.

Vorzugweise weist die Vorrichtung eine visuelle Endpunktsanzeige an, bei der durch Sichtfenster das Erreichen der Endposition des Kanülenträgers und damit das Durchstechen des Verschlusses des zweiten Behältnisses mittels der Kanüle nachvollzogen werden kann. Der zweite Hohlkörper ist hierzu seitlich mit dem oder den Sichtfenstern versehen.Preferably, the device has a visual endpoint indication, in which through viewing window reaching the end position of the cannula holder and thus the piercing of the closure of the second container by means of the cannula can be reconstructed. The second hollow body is this side with the or provided the viewing windows.

Zum unmittelbaren Gebrauch ist die Vorrichtung, das heißt mit den beiden in den Hohlkörpern vormontierten Behältnissen in eine Verpackung, insbesondere eine Weichplister-Verpackung, eingesiegelt. Es besteht somit während der Rekonstitutionsprozedur keine Gefahr der mikrobiologischen Kontamination, da der Überleitvorgang innerhalb der sterilen äußeren Verpackung stattfinden kann, und sie zudem ein Lagern des rekonstituierten Produktes unter sterilen Bedingungen ermöglicht. Die erfindungsgemäße Vorrichtung verhindert überdies die Handhabung von Kanülen mit frei zugänglichen Kanülenspitzen. Es besteht keine Gefahr einer Verletzung während des Entnehmens der Produktflasche nach der Rekonstitution, weil der Kanülenträger im Gerät zurückgehalten wird. Die Vorrichtung ist wegen der Vormontage der relevanten Bauteile unmittelbar verfügbar. Innerhalb kurzer Zeit kann die Überleitung der Flüssigkeit vom ersten in das zweite Behältnis erfolgen. Dies bedingt eine erhebliche Zeiteinsparung während des Vorbereitungsprozesses. Die Rekonstitution kann durch eine einzige Person entweder schon vorher vorbereitet werden oder direkt im Sterilbereich eines Operationsraumes stattfinden.For immediate use is the device, that is with the two in the Hollow pre-assembled containers in a package, in particular a Soft pleated packaging, sealed. It thus exists during the reconstitution procedure no danger of microbiological contamination, since the Überleitvorgang within the sterile outer packaging, and moreover allows storage of the reconstituted product under sterile conditions. The device according to the invention also prevents the handling of Cannulas with freely accessible cannula tips. There is no risk of injury during removal of the product bottle after reconstitution, because the cannula carrier is retained in the device. The device is because of the Pre-assembly of the relevant components immediately available. In a short time the liquid can be transferred from the first to the second container. This requires a considerable time savings during the preparation process. Reconstitution can be prepared by a single person either before or take place directly in the sterile area of an operating room.

Weitere Merkmale der Erfindung sind in den Patentansprüchen, der Beschreibung der Figuren sowie den Figuren selbst dargestellt. Further features of the invention are in the claims, the description the figures and the figures themselves.

BeispieleExamples

In den Figuren ist die Erfindung anhand mehrerer Ausführungsbeispiele veranschaulicht, ohne auf diese beschränkt zu sein. Es zeigt:

Figur 1
eine erste Ausführungsform (eingangs erste Gestaltung genannt) der erfindungsgemäßen Vorrichtung in vormontiertem Zustand, im Querschnitt veranschaulicht,
Figur 2
in einer Explosionsdarstellung die einzelnen Teile der in Figur 1 gezeigten Vorrichtung,
Figur 3
Darstellungen a bis f zur Veranschaulichung des Zusammenbaus und der Aktivierungsschritte der in den Figuren 1 und 2 gezeigten Vorrichtung,
Figur 4
eine zweite Ausführungsform (eingangs zweite Gestaltung genannt) der erfindungsgemäßen Vorrichtung in vormontiertem Zustand, im Querschnitt veranschaulicht,
Figur 5
in einer Explosionsdarstellung die einzelnen Teile der in Figur 4 gezeigten Vorrichtung,
Figur 6
Darstellungen a bis f zur Veranschaulichung des Zusammenbaus und der Aktivierungsschritte der in den Figuren 4 und 5 gezeigten Vorrichtung,
Figuren 7A bis D
Darstellungen der in eine Blisterfolie eingeschweißten erfindungsgemäßen Vorrichtung.
In the figures, the invention is illustrated with reference to several embodiments, without being limited thereto. It shows:
FIG. 1
A first embodiment (initially referred to as the first embodiment) of the device according to the invention in the preassembled state, illustrated in cross section,
FIG. 2
in an exploded view, the individual parts of the device shown in Figure 1,
FIG. 3
Figures a to f are illustrative of the assembly and activation steps of the apparatus shown in Figures 1 and 2,
FIG. 4
A second embodiment (initially referred to as second design) of the device according to the invention in the preassembled state, illustrated in cross section,
FIG. 5
in an exploded view, the individual parts of the device shown in Figure 4,
FIG. 6
Figures a to f show the assembly and activation steps of the apparatus shown in Figures 4 and 5,
FIGS. 7A to D
Representations of the invention sealed in a blister film device.

Die Figuren 1 und 2 veranschaulichen die erfindungsgemäße Vorrichtung, auch als Überleit-System 1 bezeichnet, in einer dreiteiligen Ausführungsform. Figures 1 and 2 illustrate the device according to the invention, also as Transfer system 1, in a three-part embodiment.

Ein erster Hohlkörper 2 dient der verschiebbaren Aufnahme eines topfförmigen Kanülenträgers 3 und ist in den zweiten Hohlkörper 4 einsteckbar. Der Hohlkörper 2 dient als Halterung für eine Lösungsmittelflasche und ist zu diesem Zweck mit diversen parallel zur Längsachse des zylindrischen Hohlkörpers 2 angeordneten flexiblen Segmenten 5 versehen. Diese tragen nach innen gerichtete Wülste 6. Die Öffnung 7 des Hohlkörpers 2, die beim Gebrauch des Überleitsystems oben liegt, dient der Aufnahme der Lösungsmittelflasche. Im Bereich der unteren Öffnung 8 ist der Hohlkörper 2 mit einem inneren Führungsabschnitt 9 für den von dieser aufgenommenen Kanülenträger 3 versehen, der eine äußere komplementäre Führungsfläche 10 aufweist, so dass der Kanülenträger 3 mit geringem Spiel im Hohlkörper 2 geführt ist.A first hollow body 2 serves for the displaceable reception of a cup-shaped cannula carrier 3 and can be inserted into the second hollow body 4. The hollow body 2 serves as a holder for a solvent bottle and is for this purpose with various parallel to the longitudinal axis of the cylindrical hollow body 2 arranged flexible Segments 5 provided. These carry inward beads 6. The Opening 7 of the hollow body 2, which is at the top during use of the transfer system, serves to accommodate the solvent bottle. In the region of the lower opening 8 is the hollow body 2 with an inner guide portion 9 for the picked up by this Cannula carrier 3 provided, which has an outer complementary guide surface 10, so that the cannula carrier 3 with a small clearance in the hollow body. 2 is guided.

Der topfförmige Kanülenträger 3 nimmt im Bereich seines Bodenabschnittes 11 fest eine zentrale, axial gerichtete Transferkanüle 12 auf, die mit spitzen Enden versehen ist. Die Länge der Transferkanüle 12 ist so bemessen, dass deren jeweiligen Überstände, bezogen auf den Bodenabschnitt 1 des Kanülenträgers 3, ausreichen, um die Verschlüsse der mit der Vorrichtung zusammenwirkenden Behältnisse zu durchstechen.The cup-shaped cannula carrier 3 takes in the region of its bottom portion 11 fixed a central, axially directed transfer cannula 12, which is provided with pointed ends is. The length of the transfer cannula 12 is dimensioned such that their respective Supernatants, based on the bottom portion 1 of the cannula holder 3, sufficient to the closures of the cooperating with the device containers pierce.

Der zweite Hohlkörper 4 dient der Aufnahme des ersten Hohlkörpers 2 und des Kanülenträgers 3 in seiner vorgeschobenen Position. Das auf die Gebrauchslage der Vorrichtung bezogene untere Ende des Hohlkörpers 4 ist entsprechend der Gestaltung des Hohlkörpers 2 mit flexiblen Segmenten 13 versehen, die ihrerseits nach innen gerichtete Wülste 14 aufweisen. Durch die diesen Segmenten 13 zugeordnete Öffnung 15 des Hohlkörpers 4 wird das zweite Behältnis, das die feste oder flüssige Komponente aufnimmt, in den Hohlkörper 4 eingesteckt. Im Bereich der anderen Öffnung 16 ist der Hohlkörper 4 erweitert, so dass bei in diesem eingestecktem Hohlkörper 2 dessen flexible Segmente ausreichend Platz haben, um nach außen gespreizt zu werden. Gehalten wird der Hohlkörper 2 im Hohlkörper 4 im Bereich seines unteren, äußeren Führungsabschnittes 17, der mit einer umlaufenden Rastnut 18 versehen ist, in die im Bereich des komplementären inneren Führungsabschnittes 19 ein dortiger umlaufender Rastvorsprung 20 eingreift. In eingesteckter Position des Hohlkörpers 2 ist dieser somit bezüglich des Hohlkörpers 4 fixiert.The second hollow body 4 serves to receive the first hollow body 2 and the cannula carrier 3 in its advanced position. That on the position of use of Device related lower end of the hollow body 4 is according to the design of the hollow body 2 is provided with flexible segments 13, which in turn after have internally directed beads 14. By the these segments 13 associated Opening 15 of the hollow body 4, the second container, the solid or liquid component receives, inserted into the hollow body 4. Around other opening 16, the hollow body 4 is extended, so that when inserted in this Hollow body 2 whose flexible segments have enough space to to be spread outwards. The hollow body 2 is held in the hollow body 4 in the region of its lower, outer guide portion 17, with a circumferential Locking groove 18 is provided, in which in the region of the complementary inner Guide portion 19 a local circumferential locking projection 20 engages. In inserted position of the hollow body 2, this is thus with respect to the hollow body 4 fixed.

Auch der Kanülenträger 3 weist im Bereich seines äußeren Führungsabschnittes 10 einen umlaufenden Rastvorsprung 21 auf, der in der weitgehend von der Bodenöffnung 11 entfernten Stellung mit einer Erweiterung 22 im Hohlkörper 4 zusammenwirkt. Wird der Kanülenträger 3 durch Aufbringen einer in Richtung der Öffnung 15 gerichteten Kraft beaufschlagt, wird der Kanülenträger 3 vorgeschoben, bis dessen Rastvorsprung 21 mit einer weiter vorn im Hohlkörper 4 befindlichen Rastnut 23 des Hohlkörpers 4 rastiert. In dieser Position liegt der Kanülenträger 3 mit seinem Bodenabschnitt 11 an einem umlaufenden Ringvorsprung 24 des Hohlkörpers 4 an.Also, the cannula carrier 3 has in the region of its outer guide portion 10th a circumferential locking projection 21, in the largely from the bottom opening 11 remote position cooperates with an extension 22 in the hollow body 4. If the cannula carrier 3 by applying a in the direction of the opening 15th directed to directed force, the cannula carrier 3 is advanced until the Detent projection 21 with a further located in the front of the hollow body 4 locking groove 23rd the hollow body 4 rests. In this position, the cannula carrier 3 is with his Bottom portion 11 to a circumferential annular projection 24 of the hollow body 4 at.

In vollständig vorgeschobener Position des Kanülenträgers 3 ist dessen Stellung durch Sichtfenster 39 erkennbar, die als Löcher im Hohlkörper 4 ausgebildet sind.In fully advanced position of the cannula holder 3 is its position visible through viewing window 39, which are formed as holes in the hollow body 4.

Figur 1 veranschaulicht den Montagezustand des Überleit-Systems 1 bei in den Hohlkörper 4 eingesetztem Hohlkörper 2, vor dem Vorschieben des Kanülenträgers 3 in Richtung der Öffnung 15 im Hohlkörper 4.Figure 1 illustrates the mounting state of the transfer system 1 in the Hollow body 4 inserted hollow body 2, before advancing the cannula holder 3 in the direction of the opening 15 in the hollow body 4th

Alle Teile des insoweit beschriebenen Überleit-Systems 1 bestehen aus Kunststoff, bis auf die Metallkanüle 12.All parts of the transfer system 1 described so far are made of plastic, except for the metal cannula 12.

Figur 3 zeigt die unterschiedlichen Schritte beim Zusammenbau und bei der Aktivierung des Überleit-Systems 1. Zum Schritt a ist die Einzelteildarstellung gemäß Figur 2 veranschaulicht, ferner die zum Einstecken in den Hohlkörper 2 vorgesehene Glasflasche 25, die das Lösungsmittel aufnimmt. Die Flasche 25 ist mit einem elastischen, durchstechbaren Verschluss 26 versehen und weist im Bereich des Verschlusses eine Bördelkappe 27 auf. Entsprechend ist die andere, die feste oder flüssige Komponente aufnehmende Glasflasche 28 gestaltet, die von unten in den Hohlkörper 4 einsetzbar ist. Bei der in Figur 3 gezeigten Orientierung ― Glasflasche 25 oben und Glasflasche 28 unten ― wird, ausgehend vom Montagezustand des Überleit-Systems 1 gemäß Figur 1 bzw. Montagezustand b. in Figur 3, die Glasflasche 25 in den Hohlkörper 2 und die Glasflasche 28 in den Hohlkörper 4 eingesteckt. Hierbei hintergreifen, wie zu c. in Figur 3 verdeutlicht, die Wülste 6 der Segmente 5 und die Wülste 14 der Segmente 13 die Flaschen 25 bzw. 28, wobei die Flasche 28 am Ringvorsprung 24 des Hohlkörpers 4 anliegt. Werden die beiden Flaschen 25 und 28 nunmehr aufeinander zugedrückt oder die Glasflasche 25 in den Hohlkörper 2 weiter eingedrückt, durchsticht die Kanüle 12 des in seiner Position verbleibenden Kanülenträgers 3 den Verschluss 26 der Flasche 25, wobei beim Vorschieben der Flasche über den einen größeren Durchmesser aufweisenden Flaschenkörper die Segmente 5 des Hohlkörpers 1 nach außen gespreizt werden. Dieser Zustand ist zu d. in Figur 3 veranschaulicht. Wird weiter Kraft auf die beiden Flaschen 25 und 28 ausgeübt bzw. die Flasche 25 weiter in den Hohlkörper 2 hineinbewegt, führt dies, aufgrund der Anlage der Flasche 25 am Kanülenträger 3 zu dessen Verschiebung in Richtung der Öffnung 15 des Hohlkörpers 4. Hierbei durchsticht das andere Ende der Kanüle 12 den Verschluss 26 der Flasche 28. Bei Erreichen dieses Stadiums, das unter e. in Figur 3 veranschaulicht ist, durchsetzt der Rastvorsprung 21 des Kanülenträgers 3 die Rastnut 23 im Hohlkörper 4. Nach dem Überleiten der Flüssigkeit in die Flasche 28 wird diese aus dem Überleit-System 1 herausgezogen. Dieser Zustand ist unter f. in Figur 3 veranschaulicht.FIG. 3 shows the different steps during assembly and activation of the transfer system 1. For step a, the item view according to FIG 2 illustrates, further provided for insertion into the hollow body 2 Glass bottle 25, which takes up the solvent. The bottle 25 is equipped with an elastic, pierceable closure 26 is provided and has in the region of the closure a crimp cap 27 on. Accordingly, the other, the fixed or liquid component receiving glass bottle 28 designed from below in the Hollow body 4 can be used. In the orientation shown in Figure 3 - glass bottle 25 above and glass bottle 28 below - will, starting from the mounting condition of the Transfer system 1 according to FIG. 1 or mounting state b. in Figure 3, the glass bottle 25 inserted into the hollow body 2 and the glass bottle 28 in the hollow body 4. Underline this, as to c. clarified in Figure 3, the beads 6 of the Segments 5 and the beads 14 of the segments 13, the bottles 25 and 28, respectively the bottle 28 rests against the annular projection 24 of the hollow body 4. Be the two Bottles 25 and 28 now pushed towards each other or the glass bottle 25 in the hollow body 2 further pressed, pierces the cannula 12 of in its position remaining cannula support 3, the closure 26 of the bottle 25, wherein the Advance the bottle over the larger diameter Bottle body, the segments 5 of the hollow body 1 are spread outwards. This condition is too d. illustrated in FIG. Will continue to force the two 25 and 28 exercised or the bottle 25 further moved into the hollow body 2, This leads, due to the investment of the bottle 25 on the cannula carrier 3 to its displacement in the direction of the opening 15 of the hollow body 4. Here pierces the other end of the cannula 12, the closure 26 of the bottle 28. Bei Reaching this stage under e. is illustrated in Figure 3, interspersed the locking projection 21 of the cannula carrier 3, the locking groove 23 in the hollow body 4. Nach passing the liquid into the bottle 28, this is from the transfer system 1 pulled out. This condition is under f. illustrated in FIG.

Die Ausführungsform gemäß der Figuren 4 und 5 unterscheidet sich von derjenigen nach den Figuren 1 und 2 dadurch, dass statt der beiden Bauteile ― Hohlkörper 2 und Kanülenträger 3 ― ein Bauteil 29 vorgesehen ist, das die Funktion dieser beiden Bauteile in sich vereinigt. Mit der Ausführungsform gemäß der Figuren 1 und 2 sowie der Funktionsdarstellung gemäß Figur 3 übereinstimmende Bauteile sind in den Figuren 4 und 5 sowie der Funktionsdarstellung nach Figur 6 der Einfachheit halber mit denselben Bezugsziffern bezeichnet. The embodiment according to Figures 4 and 5 differs from that according to Figures 1 and 2, characterized in that instead of the two components - hollow body. 2 and cannula support 3 - a component 29 is provided, the function of these two Components united in one another. With the embodiment according to FIGS. 1 and 2 as well as the functional representation according to Figure 3 matching components are in Figures 4 and 5 and the functional representation of Figure 6 simplicity half the same reference numerals.

Wie der Darstellung der Figuren 4 und 5 zu entnehmen ist, ist die Baueinheit 29 topfförmig ausgebildet und wird durch den zylindrischen Hohlkörper 2 und den Kanülenträger 3 gebildet. Die Baueinheit 29 ist mit einem äußeren umlaufenden Rastvorsprung 30 versehen, dessen Funktion der des Rastvorsprunges 21 am Kanülenträger 3 bei der Ausführungsform gemäß der Figuren 1 und 2 entspricht. Der äußere Führungsabschnitt 31 der Baueinheit 29 wirkt mit dem inneren Führungsabschnitt 32 des Hohlkörpers 4 zusammen, der in den beiden Funktionsstellungen des Kanülenträgers 3 der Baueinheit 29 mit inneren Rastnuten 33 bzw. 34 versehen ist, die in ihrer Funktion der Erweiterung 22 bzw. der Rastnut 23 des Hohlkörpers 2 bei der zuvor beschriebenen Ausführungsform entsprechen.As can be seen from the illustration of FIGS. 4 and 5, the structural unit 29 is cup-shaped and is formed by the cylindrical hollow body 2 and the cannula carrier 3 formed. The assembly 29 is provided with an outer circumferential locking projection 30 provided, whose function is that of the locking projection 21 on the cannula carrier 3 in the embodiment according to Figures 1 and 2 corresponds. Of the outer guide portion 31 of the assembly 29 interacts with the inner guide portion 32 of the hollow body 4 together, in the two functional positions the cannula support 3 of the assembly 29 is provided with inner locking grooves 33 and 34, respectively is that in their function of the extension 22 and the locking groove 23 of the hollow body 2 in the embodiment described above.

Bezogen auf die Darstellung der Figur 4 und der Figur 6 werden nach dem Montieren des Überleit-Systems 1 die Flaschen 25 und 28 in dieses eingesteckt, wobei die obere Flasche 25 mit ihrer Bördelkappe 27 in einen umlaufenden Rücksprung 35 der flexiblen Segmente 5 der Baueinheit 29 eingreift. Beim weiteren Vorschieben der Flasche 25 vom Zustand c. in den Zustand d. in Figur 6 werden über den Flaschenkörper die Segmente 5 nach außen gespreizt und die Bördelkappe 27 der Flasche 25 gegen den Kanülenträger 3, insbesondere im Bereich des Vorsprunges 36, der die Kanüle 12 trägt, bewegt. Beim weiteren Vorschieben der Flasche 25 wird die Baueinheit 29 mit ihrem Rastvorsprung 30 aus der Rastnut 33 des Hohlkörpers 4 herausbewegt. Die untere Endstellung des Kanülenträgers 3 ist zu e. in Figur 6 veranschaulicht; in dieser Position hat der Rastvorsprung 30 der Baueinheit 29 die Rastnut 34 des Hohlkörpers 4 erreicht und die Kanüle 12 hat den Verschluss 26 der unteren Flasche 28 durchstochen. Die Entnahmesituation dieser Flasche ist zu f. in Figur 6 verdeutlicht.Referring to the illustration of Figure 4 and Figure 6 are after mounting the transfer system 1, the bottles 25 and 28 inserted into this, the upper bottle 25 with its crimp cap 27 in a circumferential recess 35th the flexible segments 5 of the assembly 29 engages. On further advancement the bottle 25 from the state c. in the state d. in Figure 6 are over the bottle body the segments 5 spread outwards and the crimp cap 27 of the Bottle 25 against the cannula carrier 3, in particular in the region of the projection 36, which carries the cannula 12 moves. Upon further advancement of the bottle 25 is the assembly 29 with its locking projection 30 of the locking groove 33 of the hollow body 4 moved out. The lower end position of the cannula holder 3 is to e. in Figure 6 illustrates; in this position, the locking projection 30 of the unit 29 reaches the locking groove 34 of the hollow body 4 and the cannula 12 has the closure 26 of the lower bottle 28 pierced. The removal situation of this Bottle is too f. illustrated in FIG.

Die Figuren 7A bis 7D veranschaulichen ein in eine Blisterfolie eingeschweißtes Überleit-System 1 mit den in dieses eingesetzten Flaschen 25 und 28, in einem Zustand, wie er in den Figuren 3 und 6 zum Stadium c. veranschaulicht ist. Die Blisterfolie 37 ist mit einem Siegelpapier 38 verschweißt, das vorzugsweise für ein Sterilisationsmittel durchgängig ist.Figures 7A to 7D illustrate a shrink-wrapped in a blister sheet Transfer system 1 with the bottles used in this 25 and 28, in one Condition, as shown in Figures 3 and 6 to the stage c. is illustrated. The Blister foil 37 is welded to a sealing paper 38, preferably for a Sterilization agent is consistent.

Figur 7A zeigt die Anordnung in einer Draufsicht, Figur 7B diese in einer Seitenansicht, die Figuren 7C und 7D stellen Schnitte gemäß der Linien A-A und B-B in Figur 7A dar. FIG. 7A shows the arrangement in a plan view, FIG. 7B shows this in a side view, FIGS. 7C and 7D show sections along the lines A-A and B-B in FIG 7A

BezugszeichenlisteLIST OF REFERENCE NUMBERS

11
Überleitsystemtransfer system
22
erster Hohlkörperfirst hollow body
33
Kanülenträgercannula support
44
zweiter Hohlkörpersecond hollow body
55
flexible Segmenteflexible segments
66
Wulstbead
77
Öffnungopening
88th
Öffnungopening
99
Führungsabschnittguide section
1010
Führungsabschnittguide section
1111
Bodenabschnittbottom section
1212
Transferkanületransfer cannula
1313
Segmentsegment
1414
Wulstbead
1515
Öffnungopening
1616
Öffnungopening
1717
Führungsabschnittguide section
1818
Rastnutlocking groove
1919
Führungsabschnittguide section
2020
Rastvorsprungcatch projection
2121
Rastvorsprungcatch projection
2222
Erweiterungextension
2323
Rastnutlocking groove
2424
Ringvorsprungannular projection
2525
Glasflascheglass bottle
2626
Verschlussshutter
2727
Bördelkappeflanged
2828
Glasflasche glass bottle
2929
Baueinheitunit
3030
Rastvorsprungcatch projection
3131
Führungsabschnittguide section
3232
Führungsabschnittguide section
3333
Rastnutlocking groove
3434
Rastnutlocking groove
3535
Rücksprungreturn
3636
Vorsprunghead Start
3737
Blisterfolieblister
3838
Siegelpapierseal paper
3939
Sichtfensterwindow

Claims (14)

Vorrichtung zum Zusammenführen einer in einem ersten Behältnis aufgenommenen flüssigen Komponente und einer in einem zweiten Behältnis aufgenommenen festen oder flüssigen Komponente unter sterilen Bedingungen, gekennzeichnet durch einen ersten zylindrischen Hohlkörper (2) zur Aufnahme des ersten Behältnisses (25) im Bereich dessen Verschlusses (26) in einer Aufnahmeöffnung (7) dieses Hohlkörpers (2) und einen zweiten zylindrischen Hohlkörper (4) zur Aufnahme des zweiten Behältnisses (28) im Bereich dessen Verschlusses (26) in einer diametral angeordneten Aufnahmeöffnung (15), wobei die beiden Hohlkörper (2, 4) ineinander gesteckt und in deren Längsrichtung geführt relativ zueinander verschiebbar sind, sowie ein eine topfförmige Baueinheit (29) mit dem ersten Hohlkörper (2) bildender Kanülenträger (3) mit mindestens einer von diesem aufgenommenen Kanüle (12) versehen ist.Device for combining a liquid component accommodated in a first container and a solid or liquid component received in a second container under sterile conditions, characterized by a first cylindrical hollow body (2) for receiving the first container (25) in the region of its closure (26) in a receiving opening (7) of this hollow body (2) and a second cylindrical hollow body (4) for receiving the second container (28) in the region of the closure (26) in a diametrically arranged receiving opening (15), wherein the two hollow body (2, 4) are inserted into one another and guided in their longitudinal direction are displaceable relative to each other, and a cup-shaped unit (29) with the first hollow body (2) forming cannula carrier (3) with at least one of this received cannula (12) is provided. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der Kanülenträger (3) den Boden des Topfes und der erste Hohlkörper (2) die Topfwandung bildet.Apparatus according to claim 1, characterized in that the cannula carrier (3) forms the bottom of the pot and the first hollow body (2) the pot wall. Vorrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass die Topfwandung mindestens einen Führungsabschnitt (31) aufweist, der mit mindestens einem Führungsabschnitt (32) des zweiten Hohlkörpers (4) zusammenwirkt. Apparatus according to claim 1 or 2, characterized in that the pot wall has at least one guide portion (31) which cooperates with at least one guide portion (32) of the second hollow body (4). Vorrichtung zum Zusammenführen einer in einem ersten Behältnis aufgenommenen flüssigen Komponente und einer in einem zweiten Behältnis aufgenommenen festen oder flüssigen Komponente unter sterilen Bedingungen, gekennzeichnet durch einen ersten zylindrischen Hohlkörper (2) zur Aufnahme des ersten Behältnisses (25) im Bereich dessen Verschlusses (26) in einer Aufnahmeöffnung (7) dieses Hohlkörpers (2) und einen zweiten zylindrischen Hohlkörper (4) zur Aufnahme des zweiten Behältnisses (28) im Bereich dessen Verschlusses (26) in einer diametral angeordneten Aufnahmeöffnung (15), wobei die beiden Hohlkörper (2, 4) ineinander gesteckt sind, der erste Hohlkörper (2) und ein topfförmiger Kanülenträger (3) mit mindestens einer von diesem aufgenommenen Kanüle (12) separate Bauteile bilden, sowie der erste Hohlkörper (2) und der Kanülenträger (3) ineinander gesteckt und in Längsrichtung der beiden Hohlkörper (2, 4) geführt relativ zueinander verschiebbar sind.Device for combining a liquid component accommodated in a first container and a solid or liquid component received in a second container under sterile conditions, characterized by a first cylindrical hollow body (2) for receiving the first container (25) in the region of its closure (26) in a receiving opening (7) of this hollow body (2) and a second cylindrical hollow body (4) for receiving the second container (28) in the region of the closure (26) in a diametrically arranged receiving opening (15), wherein the two hollow body (2, 4) are inserted into each other, the first hollow body (2) and a cup-shaped cannula carrier (3) with at least one cannula (12) received by this separate components, and the first hollow body (2) and the cannula carrier (3) inserted into each other and in Longitudinal direction of the two hollow body (2, 4) guided relative to each other are displaceable. Vorrichtung nach Anspruch 4, dadurch gekennzeichnet, dass der erste Hohlzylinder (2) beidseitig offen ist.Apparatus according to claim 4, characterized in that the first hollow cylinder (2) is open on both sides. Vorrichtung nach Anspruch 4 oder 5, dadurch gekennzeichnet, dass die Topfwandung mindestens einen Führungsabschnitt (10) aufweist, der mit mindestens einem Führungsabschnitt (9) des ersten Hohlkörpers (2) zusammenwirkt.Apparatus according to claim 4 or 5, characterized in that the pot wall has at least one guide portion (10) cooperating with at least one guide portion (9) of the first hollow body (2). Vorrichtung nach einem der Ansprüche 4 bis 6, dadurch gekennzeichnet, dass der erste Hohlkörper (2) bei in diesen eingesetztem ersten Behältnis (25) im zweiten Hohlkörper (4) unverschieblich gelagert ist.Device according to one of claims 4 to 6, characterized in that the first hollow body (2) is mounted immovably in inserted in this first container (25) in the second hollow body (4). Vorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass der erste (2) und/oder zweite Hohlkörper (4) im Bereich seines behälterseitigen Endes (7, 15) segmentartig (Segmente 5 bzw. 13) ausgebildet ist. Device according to one of claims 1 to 7, characterized in that the first (2) and / or second hollow body (4) in the region of its container-side end (7, 15) segment-like (segments 5 and 13) is formed. Vorrichtung nach Anspruch 8, dadurch gekennzeichnet, dass die Segmente (5, 13) Spreizlappen bilden, die eine Bördelkappe (27) des Behältnisses (25 bzw. 28) umgreifen.Apparatus according to claim 8, characterized in that the segments (5, 13) form expansion tabs, which surround a crimp cap (27) of the container (25 or 28). Vorrichtung nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass der Kanülenträger (3) mit einer einzigen Kanüle (12) bestückt ist.Device according to one of claims 1 to 9, characterized in that the cannula carrier (3) is equipped with a single cannula (12). Vorrichtung nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass die Behältnisse (25, 28) als Fläschchen ausgebildet sind, insbesondere als Fläschchen mit einem Füllvolumen von 1 bis 10 ml.Device according to one of claims 1 to 10, characterized in that the containers (25, 28) are formed as vials, in particular as a vial with a filling volume of 1 to 10 ml. Vorrichtung nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass der zweite Hohlkörper (4) seitlich mit einer oder mehreren Sichtfenstern (39) zur Anzeige der Stellung des Kanülenträgers (3) versehen sind.Device according to one of claims 1 to 11, characterized in that the second hollow body (4) are provided laterally with one or more viewing windows (39) for displaying the position of the cannula holder (3). Vorrichtung nach einem der Ansprüche 1 bis 12, dadurch gekennzeichnet, dass Rastmittel (21, 30) zum Rastieren des Kanülenträgers (3) oder des ersten Hohlkörpers (2) in unterschiedlichen Positionen des Kanülenträgers (3) in komplementären Rastmitteln (22, 23, 33, 34) des zweiten Hohlkörpers (4) vorgesehen sind.Device according to one of claims 1 to 12, characterized in that latching means (21, 30) for locking the cannula holder (3) or the first hollow body (2) in different positions of the cannula holder (3) in complementary latching means (22, 23, 33 , 34) of the second hollow body (4) are provided. Vorrichtung nach einem der Ansprüche 1 bis 13, dadurch gekennzeichnet, dass die beiden Hohlkörper (2, 4) mit den vormontierten Behältnissen (25, 28) in eine Verpackung, insbesondere eine Weichblister-Verpackung (37, 38), sterilisierbar eingesiegelt sind.Device according to one of claims 1 to 13, characterized in that the two hollow bodies (2, 4) with the pre-assembled containers (25, 28) in a packaging, in particular a soft-blister packaging (37, 38) are sealed sterilizable.
EP20020017985 2001-08-31 2002-08-10 Device for bringing components together in sterile conditions Expired - Lifetime EP1287804B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142450 2001-08-31
DE2001142450 DE10142450C1 (en) 2001-08-31 2001-08-31 Device for bringing components together under sterile conditions

Publications (3)

Publication Number Publication Date
EP1287804A2 true EP1287804A2 (en) 2003-03-05
EP1287804A3 EP1287804A3 (en) 2003-10-29
EP1287804B1 EP1287804B1 (en) 2012-02-01

Family

ID=7697074

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020017985 Expired - Lifetime EP1287804B1 (en) 2001-08-31 2002-08-10 Device for bringing components together in sterile conditions

Country Status (11)

Country Link
US (1) US8172824B2 (en)
EP (1) EP1287804B1 (en)
JP (1) JP4359030B2 (en)
KR (1) KR100895418B1 (en)
AT (1) ATE543482T1 (en)
AU (1) AU2002300778B2 (en)
CA (1) CA2399826C (en)
DE (1) DE10142450C1 (en)
DK (1) DK1287804T3 (en)
ES (1) ES2380655T3 (en)
MX (1) MXPA02007786A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007082325A1 (en) 2006-01-18 2007-07-26 Friedrich Pipelka Container for placing at least one unsterile vessel into a sterile region
EP1829518A1 (en) * 2004-12-16 2007-09-05 Zhongshan Botai Pharmaceutic Instruments Co., Ltd. Medicine mixer for applying drug
DE102006031712B3 (en) * 2006-07-08 2007-12-06 Haindl, Hans, Dr.med. Dipl.-Ing. Fluid transfer device, has guide, block and anti-block that are provided to block movement of transfer part in direction of bottle containing medicament and to release movement when pin transfixes connector of bottle containing fluid
CN108433816A (en) * 2018-04-17 2018-08-24 朱斌兵 A kind of adjustable type rack for medical instrument
CN109862863A (en) * 2016-11-21 2019-06-07 泰尔茂株式会社 Medical fluid fills unit, medical fluid fill assembly and filling connector

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048724B2 (en) * 2002-12-17 2006-05-23 Denver Biomedicals, Inc. Device for withdrawing body fluids
US7597680B2 (en) * 2005-02-09 2009-10-06 Kaken Pharmaceutical Co., Ltd. Syringe device and method of preparing medicine using the device
US20060184103A1 (en) * 2005-02-17 2006-08-17 West Pharmaceutical Services, Inc. Syringe safety device
EP1820485B1 (en) * 2006-02-16 2009-11-11 F.Hoffmann-La Roche Ag System and apparatus for extracting drugs
ES2544556T3 (en) 2006-05-25 2015-09-01 Bayer Healthcare Llc Reconstitution device
DE102007031799B3 (en) * 2007-07-07 2008-10-16 Haindl, Hans, Dr. med. Needle device for the removal of spinal fluid (cerebrospinal fluid)
JP5333850B2 (en) * 2009-07-15 2013-11-06 ニプロ株式会社 Connecting device
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
US8424713B2 (en) * 2009-12-17 2013-04-23 Michael J. Bolland Multiple container retaining device and method for using same
US8684994B2 (en) 2010-02-24 2014-04-01 Medimop Medical Projects Ltd. Fluid transfer assembly with venting arrangement
EP2512398B1 (en) 2010-02-24 2014-08-27 Medimop Medical Projects Ltd. Liquid drug transfer device with vented vial adapter
EP2635335B1 (en) * 2010-11-01 2021-01-13 GE Healthcare Limited Pierce and fill device
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
JP5888606B2 (en) * 2012-06-18 2016-03-22 ニプロ株式会社 Drug preparation device
ES2836824T3 (en) * 2012-06-27 2021-06-28 Carmel Pharma Ab Medical connection device
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
JP5868555B2 (en) 2012-09-13 2016-02-24 メディモップ・メディカル・プロジェクツ・リミテッド Nested female vial adapter
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor
BR112015027555B1 (en) 2013-05-10 2022-02-01 Medimop Medical Projects Ltd Medical device for use with a needleless syringe, a vial and a liquid carrier to fill the needleless syringe with an injection solution for injection into a patient
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
JP3205560U (en) 2013-08-07 2016-08-04 メディモップ・メディカル・プロジェクツ・リミテッド Liquid transfer device for use with a drip liquid container
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
JP6191378B2 (en) * 2013-10-16 2017-09-06 ニプロ株式会社 Medical containers and transfer tools
WO2015085110A1 (en) * 2013-12-04 2015-06-11 Wayne State University Fluid sample transfer adaptor and related methods and devices
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
CA159103S (en) * 2014-04-29 2015-06-01 Bayer Animal Health Gmbh Transfer device
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
AU2015360746B2 (en) 2014-12-08 2020-10-01 Genentech, Inc. Versatile syringe platform
DE102015107312A1 (en) * 2014-12-30 2016-06-30 Sfm Medical Devices Gmbh Mixing and / or transfer device
US10285907B2 (en) 2015-01-05 2019-05-14 West Pharma. Services IL, Ltd. Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
MX2017013994A (en) * 2015-05-06 2018-03-14 Kocher Plastik Maschinenbau Gmbh Transfer system for containers.
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
EP3380058B1 (en) 2015-11-25 2020-01-08 West Pharma Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including identical twin vial adapters
IL246073A0 (en) 2016-06-06 2016-08-31 West Pharma Services Il Ltd Fluid transfer devices for use with drug pump cartridge having slidable driving plunger
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Syringe assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd Liquid transfer device for use with infusion liquid container and pincers-like hand tool for use therewith for releasing intact drug vial therefrom
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd User actuated liquid drug transfer devices for use in ready-to-use (rtu) liquid drug transfer assemblages
US11275096B2 (en) * 2017-09-28 2022-03-15 Bioceryx Technologies Inc. Blood transfer devices and methods thereof
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd Dual vial adapter assemblages with twin vented female vial adapters
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1630477S (en) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (en) 2019-01-17 2019-12-16
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
IL307176A (en) 2019-04-30 2023-11-01 West Pharma Services Il Ltd Liquid transfer device with dual lumen iv spike
GB201918663D0 (en) 2019-12-17 2020-01-29 Oribiotech Ltd A connector
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
CA3198353A1 (en) 2020-10-09 2022-04-14 Icu Medical, Inc. Fluid transfer device and method of use for same
US20220125681A1 (en) * 2020-10-26 2022-04-28 Chad Jensen Medicament compounding devices, systems, and methods
EP4112035A1 (en) * 2021-06-29 2023-01-04 Kairish Innotech Private Ltd. Tray for positioning a medical vial together with a vial adapter in a fixed positional relationship relative to each other and packaging unit comprising the same
EP4124330B1 (en) * 2021-07-26 2023-08-23 Kairish Innotech Private Ltd. Component mixing apparatus and system including a cannula for fluid transfer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0737467A1 (en) 1995-04-11 1996-10-16 BEHRINGWERKE Aktiengesellschaft Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180070A (en) * 1977-08-29 1979-12-25 Abbott Laboratories Disposable double vial syringe
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
JPH06239352A (en) * 1993-02-05 1994-08-30 Nissho Corp Solution injection set
JPH0871121A (en) * 1994-09-02 1996-03-19 Terumo Corp Medicine housing container
FR2738550B1 (en) * 1995-09-11 1997-11-07 Biodome DEVICE FOR SEALING A CONTAINER ITSELF CLOSED, ASSEMBLY FOR PROVIDING A PRODUCT COMPRISING SUCH A CONTAINER AND SUCH A SEALING DEVICE
DE19604113C2 (en) * 1996-02-06 2000-10-26 Schott Glas Single-chamber transfer system for active substances, and the fully assembled transfer container
EP0904763B1 (en) * 1997-09-25 2005-12-14 Becton Dickinson France S.A. A locking ring connector assembly for a vial
US6090093A (en) * 1997-09-25 2000-07-18 Becton Dickinson And Company Connector assembly for a vial having a flexible collar
US6019750A (en) * 1997-12-04 2000-02-01 Baxter International Inc. Sliding reconstitution device with seal
US6209738B1 (en) * 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
US6022339A (en) * 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container
FR2783808B1 (en) * 1998-09-24 2000-12-08 Biodome CONNECTION DEVICE BETWEEN A CONTAINER AND A CONTAINER AND READY-TO-USE ASSEMBLY COMPRISING SUCH A DEVICE
US6558365B2 (en) * 2001-01-03 2003-05-06 Medimop Medical Projects, Ltd. Fluid transfer device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0737467A1 (en) 1995-04-11 1996-10-16 BEHRINGWERKE Aktiengesellschaft Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1829518A1 (en) * 2004-12-16 2007-09-05 Zhongshan Botai Pharmaceutic Instruments Co., Ltd. Medicine mixer for applying drug
EP1829518A4 (en) * 2004-12-16 2009-08-19 Zhongshan Botai Pharmaceutic I Medicine mixer for applying drug
WO2007082325A1 (en) 2006-01-18 2007-07-26 Friedrich Pipelka Container for placing at least one unsterile vessel into a sterile region
US8137332B2 (en) 2006-01-18 2012-03-20 Friedrich Pipelka Container for introducing at least one non-sterile vessel in a sterile region
DE102006031712B3 (en) * 2006-07-08 2007-12-06 Haindl, Hans, Dr.med. Dipl.-Ing. Fluid transfer device, has guide, block and anti-block that are provided to block movement of transfer part in direction of bottle containing medicament and to release movement when pin transfixes connector of bottle containing fluid
WO2008006439A1 (en) * 2006-07-08 2008-01-17 Hans Haindl Transfer device for transferring a liquid from a first vial into a second vial
CN109862863A (en) * 2016-11-21 2019-06-07 泰尔茂株式会社 Medical fluid fills unit, medical fluid fill assembly and filling connector
CN108433816A (en) * 2018-04-17 2018-08-24 朱斌兵 A kind of adjustable type rack for medical instrument

Also Published As

Publication number Publication date
ES2380655T3 (en) 2012-05-17
JP4359030B2 (en) 2009-11-04
KR20030019186A (en) 2003-03-06
DE10142450C1 (en) 2003-06-18
EP1287804A3 (en) 2003-10-29
JP2003126221A (en) 2003-05-07
KR100895418B1 (en) 2009-05-07
CA2399826A1 (en) 2003-02-28
US20030069538A1 (en) 2003-04-10
ATE543482T1 (en) 2012-02-15
US8172824B2 (en) 2012-05-08
CA2399826C (en) 2011-09-27
AU2002300778B2 (en) 2008-01-31
EP1287804B1 (en) 2012-02-01
DK1287804T3 (en) 2012-05-07
MXPA02007786A (en) 2004-07-16

Similar Documents

Publication Publication Date Title
EP1287804B1 (en) Device for bringing components together in sterile conditions
DE19513666C1 (en) Device for bringing together a first liquid and a second solid or liquid component by means of negative pressure under sterile conditions
EP2903583B1 (en) Transfer device for tapping or delivering a fluid
DE69922147T2 (en) SLIDING RECOVERY DEVICE FOR A DILUENT CONTAINER
DE60210735T2 (en) Transfer device and system with a cap assembly, a container and the transfer device
EP2667838B1 (en) Connecting device for connecting a first reservoir to a second reservoir
DE2028662C3 (en) Blood collection needle
DE10247963A1 (en) Pre-filled syringe with membrane seal, has cylinder, connector and sealing membrane constructed in one piece as plastic injection-molded part
DE3817101C2 (en) Device for transferring liquid from one container to another container
WO2006042579A1 (en) Closing cap for containers filled with medical liquids
EP0509281A2 (en) Container closure with perforable seal
DE4434644A1 (en) Container for the storage and administration of injection, infusion and diagnostic preparations
EP2300081A1 (en) Ampoule having ampoule holder
EP2155140A1 (en) Puncture device and method for removing a fluid from a bag or introducing a substance into a bag
EP3565766A1 (en) Container
EP3250171B1 (en) Device for transferring a fluid between a storage container and at least one further container for use
DE102008034677B4 (en) Identification and sampling device for animals
DE2815377B2 (en) Device for collecting blood
DE102004044288A1 (en) Device for connecting a tubular part, in particular a cannula, to the inside of a bottle or the like
EP2049061B1 (en) Device for combining components by means of negative pressure under sterile conditions
DE212022000138U1 (en) Device and system for reconstituting a drug by liquid transfer
DE19604113C2 (en) Single-chamber transfer system for active substances, and the fully assembled transfer container
DE4332087A1 (en) Closure and removal device
DE102009015724B4 (en) Containers for securing, storing and transporting biological samples
EP3250172A1 (en) Device for transferring a fluid between a storage container and at least one further container for use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20040429

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ZLB BEHRING GMBH

17Q First examination report despatched

Effective date: 20041216

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CSL BEHRING GMBH

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 543482

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120215

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 50215367

Country of ref document: DE

Effective date: 20120329

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2380655

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20120517

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20120400991

Country of ref document: GR

Effective date: 20120614

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20121105

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 50215367

Country of ref document: DE

Effective date: 20121105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120501

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20200814

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20200804

Year of fee payment: 19

Ref country code: GR

Payment date: 20200715

Year of fee payment: 19

Ref country code: FI

Payment date: 20200811

Year of fee payment: 19

Ref country code: DK

Payment date: 20200811

Year of fee payment: 19

Ref country code: TR

Payment date: 20200806

Year of fee payment: 19

Ref country code: ES

Payment date: 20200901

Year of fee payment: 19

Ref country code: IE

Payment date: 20200811

Year of fee payment: 19

Ref country code: GB

Payment date: 20200729

Year of fee payment: 19

Ref country code: FR

Payment date: 20200715

Year of fee payment: 19

Ref country code: LU

Payment date: 20200724

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20200715

Year of fee payment: 19

Ref country code: IT

Payment date: 20200713

Year of fee payment: 19

Ref country code: CH

Payment date: 20200814

Year of fee payment: 19

Ref country code: AT

Payment date: 20200728

Year of fee payment: 19

Ref country code: SE

Payment date: 20200811

Year of fee payment: 19

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 50215367

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20210831

REG Reference to a national code

Ref country code: FI

Ref legal event code: MAE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20210901

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 543482

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210810

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20210831

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20210810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210811

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220308

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220301

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210811