EP1301119A1 - Probe and apparatus for measuring cerebral hemodynamics and oxygenation - Google Patents
Probe and apparatus for measuring cerebral hemodynamics and oxygenationInfo
- Publication number
- EP1301119A1 EP1301119A1 EP01960517A EP01960517A EP1301119A1 EP 1301119 A1 EP1301119 A1 EP 1301119A1 EP 01960517 A EP01960517 A EP 01960517A EP 01960517 A EP01960517 A EP 01960517A EP 1301119 A1 EP1301119 A1 EP 1301119A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- probe
- light
- transmission means
- cerebral
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 title claims abstract description 80
- 230000002490 cerebral effect Effects 0.000 title claims abstract description 30
- 238000006213 oxygenation reaction Methods 0.000 title claims abstract description 13
- 230000000004 hemodynamic effect Effects 0.000 title claims description 7
- 238000000576 coating method Methods 0.000 claims abstract description 24
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 210000003625 skull Anatomy 0.000 claims abstract description 19
- 210000001519 tissue Anatomy 0.000 claims abstract description 15
- 241001269524 Dura Species 0.000 claims abstract description 11
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 6
- 210000004289 cerebral ventricle Anatomy 0.000 claims abstract description 4
- 230000005540 biological transmission Effects 0.000 claims description 55
- 230000003287 optical effect Effects 0.000 claims description 23
- 239000000835 fiber Substances 0.000 claims description 19
- 239000013307 optical fiber Substances 0.000 claims description 14
- 238000011156 evaluation Methods 0.000 claims description 12
- 230000003595 spectral effect Effects 0.000 claims description 5
- 238000012546 transfer Methods 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 239000004945 silicone rubber Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 238000004497 NIR spectroscopy Methods 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 210000005013 brain tissue Anatomy 0.000 description 11
- 238000012544 monitoring process Methods 0.000 description 10
- 230000003727 cerebral blood flow Effects 0.000 description 9
- 210000004556 brain Anatomy 0.000 description 8
- BDBMLMBYCXNVMC-UHFFFAOYSA-O 4-[(2e)-2-[(2e,4e,6z)-7-[1,1-dimethyl-3-(4-sulfobutyl)benzo[e]indol-3-ium-2-yl]hepta-2,4,6-trienylidene]-1,1-dimethylbenzo[e]indol-3-yl]butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS(O)(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C BDBMLMBYCXNVMC-UHFFFAOYSA-O 0.000 description 7
- 229960004657 indocyanine green Drugs 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 108010064719 Oxyhemoglobins Proteins 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 208000029028 brain injury Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009429 electrical wiring Methods 0.000 description 3
- 238000002496 oximetry Methods 0.000 description 3
- 210000000701 subdural space Anatomy 0.000 description 3
- 230000002861 ventricular Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000006931 brain damage Effects 0.000 description 1
- 231100000874 brain damage Toxicity 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002106 pulse oximetry Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6864—Burr holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
- A61B5/031—Intracranial pressure
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01960517A EP1301119B1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
EP04105664A EP1504715A1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00115732 | 2000-07-21 | ||
EP00115732 | 2000-07-21 | ||
EP01960517A EP1301119B1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
PCT/EP2001/008331 WO2002007592A1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04105664A Division EP1504715A1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1301119A1 true EP1301119A1 (en) | 2003-04-16 |
EP1301119B1 EP1301119B1 (en) | 2005-06-15 |
Family
ID=8169324
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04105664A Ceased EP1504715A1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
EP01960517A Expired - Lifetime EP1301119B1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04105664A Ceased EP1504715A1 (en) | 2000-07-21 | 2001-07-19 | Probe and apparatus for measuring cerebral hemodynamics and oxygenation |
Country Status (9)
Country | Link |
---|---|
US (1) | US7120481B2 (en) |
EP (2) | EP1504715A1 (en) |
JP (1) | JP3718500B2 (en) |
AT (1) | ATE297685T1 (en) |
AU (1) | AU2001281996A1 (en) |
CA (1) | CA2416546C (en) |
DE (1) | DE60111531T2 (en) |
ES (1) | ES2242761T3 (en) |
WO (1) | WO2002007592A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168475A1 (en) | 2008-09-25 | 2010-03-31 | NeMoDevices AG | Device for diagnosis and/or therapy of physiological characteristics of a selected portion of a body by optical reflectance or optical transmission |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10315574A1 (en) * | 2003-04-05 | 2004-10-28 | ETH Zürich | Device for determining blood flow in an organ |
EP1547515A1 (en) * | 2003-12-22 | 2005-06-29 | Barts and The London National Health Service Trust | Optical fibre catheter pulse oximeter |
US7570979B2 (en) * | 2004-03-30 | 2009-08-04 | Philip George Cooper | Methods and apparatus for patient monitoring |
JP3721408B2 (en) * | 2004-04-06 | 2005-11-30 | 国立大学法人 岡山大学 | Brain ischemia monitoring monitor |
US7341562B2 (en) * | 2004-12-15 | 2008-03-11 | Neuropace, Inc. | Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders |
US7819812B2 (en) | 2004-12-15 | 2010-10-26 | Neuropace, Inc. | Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders |
US9380966B2 (en) * | 2007-06-22 | 2016-07-05 | Vioptix, Inc. | Tissue retractor oximeter |
US20090204009A1 (en) * | 2008-02-07 | 2009-08-13 | Los Alamos National Security | Medical device system and related methods for diagnosing abnormal medical conditions based on in-vivo optical properties of tissue |
US8452402B2 (en) * | 2008-04-23 | 2013-05-28 | Medtronic, Inc. | Optical sensing device for use in a medical device |
US9326711B2 (en) * | 2008-06-30 | 2016-05-03 | Medtronic, Inc. | Optical perfusion sensor detector |
US8086302B2 (en) * | 2008-06-30 | 2011-12-27 | Medtronic, Inc. | Cardiac signal sensor control based on perfusion sensing |
US10058274B2 (en) * | 2008-06-30 | 2018-08-28 | Medtronic, Inc. | Tissue perfusion sensor control |
US20100022856A1 (en) * | 2008-07-28 | 2010-01-28 | Medtronic, Inc. | Implantable optical hemodynamic sensor including light transmission member |
US20100022861A1 (en) * | 2008-07-28 | 2010-01-28 | Medtronic, Inc. | Implantable optical hemodynamic sensor including an extension member |
CH699338B1 (en) * | 2008-08-06 | 2012-01-13 | Carag Ag | Device for measuring the blood flow in a body tissue. |
KR101034798B1 (en) * | 2009-03-18 | 2011-05-17 | 한국과학기술연구원 | Apparatus for detecting brain conditions |
US9737213B1 (en) * | 2009-03-24 | 2017-08-22 | Vioptix, Inc. | Using an oximeter probe to detect intestinal ischemia |
CH704900A1 (en) | 2011-05-05 | 2012-11-15 | Nemo Devices Ag | Measuring device for measuring cerebral parameters. |
US10064554B2 (en) | 2011-12-14 | 2018-09-04 | The Trustees Of The University Of Pennsylvania | Fiber optic flow and oxygenation monitoring using diffuse correlation and reflectance |
WO2014059399A1 (en) | 2012-10-12 | 2014-04-17 | University Of Virginia Patent Foundation | Oxidation measurement system and related method thereof |
CH707194A1 (en) | 2012-11-06 | 2014-05-15 | Nemodevices Ag | Measuring device for determining cerebral parameters. |
WO2014187849A1 (en) | 2013-05-22 | 2014-11-27 | Nemodevices Ag | Measurement system and method for measuring parameters in a body tissue |
JP6596430B2 (en) * | 2014-01-14 | 2019-10-23 | ザ ジェネラル ホスピタル コーポレイション | Near infrared and diffusion correlation spectroscopy devices and methods |
US10357188B2 (en) * | 2014-10-15 | 2019-07-23 | Koninklijke Philips N.V. | Flexible optical source for pulse oximetry |
US10716499B1 (en) * | 2015-03-24 | 2020-07-21 | Zoll Medical Corporation | Physiological monitoring by optical spectroscopy |
EP3302254B1 (en) | 2015-05-29 | 2021-06-23 | Carag Ag | Catheter for measuring the blood flow of a body tissue |
EP3360464A1 (en) * | 2017-02-10 | 2018-08-15 | Carag AG | Apparatus and method for measuring the blood oxygen saturation in a subject's tissue |
CN108143426A (en) * | 2017-12-26 | 2018-06-12 | 成都拓蓝医疗技术有限公司 | Blood oxygen of brain saturation degree precisely monitors sensor and its monitoring method |
CA3092738A1 (en) * | 2018-03-01 | 2019-09-06 | Archeoptix Biomedical Inc. | System for intracranial imaging and treatment |
US10973579B2 (en) | 2018-12-28 | 2021-04-13 | Industrial Technology Research Institute | Optical system |
KR102279322B1 (en) * | 2019-04-08 | 2021-07-21 | 한양대학교 산학협력단 | Multimodal diagnostic and therapeutic catheter and catheter system |
DE102019122096A1 (en) * | 2019-08-16 | 2021-02-18 | Endress+Hauser Conducta Gmbh+Co. Kg | Optochemical sensor and method |
US11730373B2 (en) * | 2020-04-20 | 2023-08-22 | Covidien Lp | Sensor with variable depth interrogation |
WO2022004742A1 (en) * | 2020-06-29 | 2022-01-06 | Ant5株式会社 | Subdural sensor |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281645A (en) * | 1977-06-28 | 1981-08-04 | Duke University, Inc. | Method and apparatus for monitoring metabolism in body organs |
GB2136120B (en) | 1983-03-10 | 1986-10-08 | Shionogi & Co | Photoelectric brain scanner and its use |
US4784150A (en) * | 1986-11-04 | 1988-11-15 | Research Corporation | Surgical retractor and blood flow monitor |
JPH06103257B2 (en) * | 1988-12-19 | 1994-12-14 | 大塚電子株式会社 | Method and apparatus for measuring absorption coefficient of substance using light scattering |
US5024226A (en) | 1989-08-17 | 1991-06-18 | Critikon, Inc. | Epidural oxygen sensor |
US5193544A (en) * | 1991-01-31 | 1993-03-16 | Board Of Trustees Of The Leland Stanford Junior University | System for conveying gases from and to a subject's trachea and for measuring physiological parameters in vivo |
US5218962A (en) * | 1991-04-15 | 1993-06-15 | Nellcor Incorporated | Multiple region pulse oximetry probe and oximeter |
US5632273A (en) * | 1994-02-04 | 1997-05-27 | Hamamatsu Photonics K.K. | Method and means for measurement of biochemical components |
US5579774A (en) * | 1994-03-07 | 1996-12-03 | Camino Neurocare, Inc. | Method and apparatus for monitoring local cerebral physiology |
US5685313A (en) | 1994-05-31 | 1997-11-11 | Brain Monitor Ltd. | Tissue monitor |
DE4445683A1 (en) * | 1994-12-21 | 1996-06-27 | Boehringer Mannheim Gmbh | Method for examining a scattering medium with intensity-modulated light |
US5524617A (en) * | 1995-03-14 | 1996-06-11 | Nellcor, Incorporated | Isolated layer pulse oximetry |
US6095974A (en) * | 1995-07-21 | 2000-08-01 | Respironics, Inc. | Disposable fiber optic probe |
JP3426847B2 (en) | 1996-05-14 | 2003-07-14 | アルプス電気株式会社 | Coordinate input device |
AU4362496A (en) | 1995-09-29 | 1997-04-17 | Swee Chuan Tjin | Fiber optic catheter for accurate flow measurements |
GB2333152B (en) | 1998-01-08 | 2002-11-06 | Diametrics Medical Ltd | Method and apparatus for monitoring cerebral physiology |
US6353226B1 (en) * | 1998-11-23 | 2002-03-05 | Abbott Laboratories | Non-invasive sensor capable of determining optical parameters in a sample having multiple layers |
US6615061B1 (en) * | 1998-11-23 | 2003-09-02 | Abbott Laboratories | Optical sensor having a selectable sampling distance for determination of analytes |
US6533733B1 (en) * | 1999-09-24 | 2003-03-18 | Ut-Battelle, Llc | Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring |
-
2001
- 2001-07-19 WO PCT/EP2001/008331 patent/WO2002007592A1/en active IP Right Grant
- 2001-07-19 EP EP04105664A patent/EP1504715A1/en not_active Ceased
- 2001-07-19 ES ES01960517T patent/ES2242761T3/en not_active Expired - Lifetime
- 2001-07-19 DE DE60111531T patent/DE60111531T2/en not_active Expired - Lifetime
- 2001-07-19 JP JP2002513337A patent/JP3718500B2/en not_active Expired - Lifetime
- 2001-07-19 US US10/333,262 patent/US7120481B2/en not_active Expired - Lifetime
- 2001-07-19 AU AU2001281996A patent/AU2001281996A1/en not_active Abandoned
- 2001-07-19 EP EP01960517A patent/EP1301119B1/en not_active Expired - Lifetime
- 2001-07-19 AT AT01960517T patent/ATE297685T1/en not_active IP Right Cessation
- 2001-07-19 CA CA002416546A patent/CA2416546C/en not_active Expired - Lifetime
Non-Patent Citations (1)
Title |
---|
See references of WO0207592A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168475A1 (en) | 2008-09-25 | 2010-03-31 | NeMoDevices AG | Device for diagnosis and/or therapy of physiological characteristics of a selected portion of a body by optical reflectance or optical transmission |
Also Published As
Publication number | Publication date |
---|---|
US7120481B2 (en) | 2006-10-10 |
DE60111531D1 (en) | 2005-07-21 |
EP1301119B1 (en) | 2005-06-15 |
ATE297685T1 (en) | 2005-07-15 |
WO2002007592A1 (en) | 2002-01-31 |
US20040039270A1 (en) | 2004-02-26 |
DE60111531T2 (en) | 2006-05-11 |
CA2416546C (en) | 2007-12-18 |
CA2416546A1 (en) | 2002-01-31 |
JP3718500B2 (en) | 2005-11-24 |
EP1504715A1 (en) | 2005-02-09 |
JP2004504092A (en) | 2004-02-12 |
ES2242761T3 (en) | 2005-11-16 |
AU2001281996A1 (en) | 2002-02-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7120481B2 (en) | Probe and apparatus for measuring cerebral hemodynamics and oxygenation | |
EP0992214B1 (en) | Pulse oximeter and sensor optimized for low saturation | |
US7349726B2 (en) | Pulse oximeter and sensor optimized for low saturation | |
US8965472B2 (en) | Method and apparatus for spectrophotometric based oximetry | |
US8428674B2 (en) | Apparatus for spectrometric based oximetry | |
JP2007532188A (en) | Photoplethysmography using spatially uniform multicolor sources | |
US7149562B2 (en) | Needle with fiberoptic capability | |
US20100105998A1 (en) | Method and apparatus for spectrophotometric based oximetry of spinal tissue | |
CA2835004C (en) | Measuring device for measuring cerebral parameters | |
KR20230154434A (en) | Methods and systems for safe injection of dermal filler procedures | |
EP4292524A1 (en) | Intracranial catheter for measuring a flow of blood | |
US20220346673A1 (en) | Methods and apparatus for near infrared spectroscopy |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030121 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
17Q | First examination report despatched |
Effective date: 20030902 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050615 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050615 Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050615 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050615 Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050615 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP Ref country code: GB Ref legal event code: FG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050719 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050719 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050719 |
|
REF | Corresponds to: |
Ref document number: 60111531 Country of ref document: DE Date of ref document: 20050721 Kind code of ref document: P |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20050731 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050915 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050915 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20050915 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: FREI PATENTANWALTSBUERO |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2242761 Country of ref document: ES Kind code of ref document: T3 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20051124 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
ET | Fr: translation filed | ||
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20060316 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: PATENTANWAELTE SCHAAD, BALASS, MENZL & PARTNER AG |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20100726 Year of fee payment: 10 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20100726 Year of fee payment: 10 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110719 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20130606 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20110720 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 16 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 17 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 18 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20200727 Year of fee payment: 20 Ref country code: FR Payment date: 20200721 Year of fee payment: 20 Ref country code: DE Payment date: 20200721 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20200710 Year of fee payment: 20 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R071 Ref document number: 60111531 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: PE20 Expiry date: 20210718 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION Effective date: 20210718 |