EP1304129A2 - Recyclable medication dispensing device - Google Patents
Recyclable medication dispensing device Download PDFInfo
- Publication number
- EP1304129A2 EP1304129A2 EP03001272A EP03001272A EP1304129A2 EP 1304129 A2 EP1304129 A2 EP 1304129A2 EP 03001272 A EP03001272 A EP 03001272A EP 03001272 A EP03001272 A EP 03001272A EP 1304129 A2 EP1304129 A2 EP 1304129A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- housing
- dial
- dose
- assembly
- drive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31571—Means preventing accidental administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Abstract
Description
- The present invention relates generally to medical dispensing devices and, more particularly, to a recyclable dispensing device that permits selectively measured dosages of a liquid to be dispensed.
- Patients suffering from diseases such as diabetes must inject themselves several times each day with an insulin solution. Since the volume of insulin solution to be injected varies from injection to injection, it is necessary for such patients to be able to measure a precise volume of insulin. Diabetics have conventionally used a syringe for injection of insulin. However, it is difficult to control the operation of the syringe as well as the quantity of drug injected.
- In order to permit a diabetic to measure and administer a more accurate and controlled dosage, injector pens have been developed which enable a particular dosage to be accurately and conveniently measured. Generally, these pens are secured onto a cartridge having a particular quantity of liquid medication sealed therein. The cartridge includes a plunger and a mechanism for advancing the plunger in the cartridge in such a manner to dispense the medication. Injector pens may be reusable or disposable. In reusable pens, a user can change a spent cartridge and reset the leadscrew of the pen back to its initial position. In a disposable pen, the cartridge is permanently captured in the pen which is disposed of after the contents of the cartridge have been exhausted.
- One such disposable pen that has functioned very adequately is disclosed in U.S.. Patent No. 5,295,976. Specifically, a dispensing device is disclosed and includes an internally threaded collar and an externally threaded plunger rod. In order to set a dosage of medication to be delivered, the collar is rotated thereby causing displacement of the collar toward the proximal end of the injection device. Rotation of the collar causes the integral cap to become effectively displaced both rotationally and axially toward the proximal end of the pen. As this displacement occurs, the segment of the dose-indicating scale which is visible through a window varies showing a linear increase in the number to indicate an increase dosage of liquid to be dispensed. Once the desired dosage is selected, a force is applied to the end of the cap causing a linear displacement of the cap, integral plunger rod, and piston to dispense liquid from the container. The dispensing displacement of the plunger rod is halted by abutting contact between the cap and a stop element.
- In U.S. Patent No. 5,308,340, another recyclable injection device is disclosed. In particular, a plunger rod is received within the housing for exerting a force on a piston closing a second end of the container. The plunger rod has a noncylindrical cross section with a first surface including threads and a second surface which can, optionally, include a series of ratchet teeth. A collar is received within the housing adjacent the second end of the container for permanently retaining the container of liquid within the housing. The plunger rod passes through the noncylindrical opening in the collar and is prevented from rotating with respect to the housing by the collar. A hollow cap envelopes the plunger rod opposite the container of liquid. The skirt of the hollow cap extends inside the housing. The cap includes a threaded interior surface which movably engages the plunger rod for calibrated adjustment relative thereto. A stop is provided within the housing, and a distal facing surface is provided on the hollow cap for contacting the stop upon linear movement of the cap and plunger rod as a unit toward the container to dispense liquid therefrom. In operation, the cap is rotated in a counterclockwise direction causing the threads of the cap to travel along the threaded portion of the rod. This rotation does not cause displacement of the plunger rod with respect to the housing, but backs the distal end of the proximal cap portion away from a stop shoulder on the inside of the housing. When the cap has been positioned to the desired dosage, pressure is applied to the end of the cap for causing it to move linearly toward the distal end of the housing until a shoulder defined by a radially exposed portion of the distal end contacts a stop.
- The present invention provides a medication injection device comprising a housing, a dose setting mechanism within the housing, and a delivery mechanism within the housing for advancing a leadscrew. A liquid medication product is housed in a variable volume cartridge within the housing of the device. Upon actuation of the delivery mechanism, the leadscrew is advanced against a movable piston in the cartridge to advance the piston thereby causing a preset quantity of medication to be delivered out of the needle of the device.
- In one embodiment, the device is made entirely out of a recyclable plastic material, except for the glass container, steel needle and label. The dose setting mechanism comprises a dial assembly including a clutching device for engaging and disengaging a generally cylindrical internally threaded nut, which is threaded onto an externally threaded leadscrew. A dose is set by rotating the nut with respect to the leadscrew. The nut is rotated by rotating the dial. However, the nut must be engaged with the dial so that rotating the dial also rotates the nut. The clutching device comprises a series of splines on the inner cylindrical surface of the dial which axially engage corresponding splines on the outer surface of the nut. The splines are engaged with one another by retracting the dial with respect to the nut after the dial has been rotated to its zero dose position.
- The dial assembly includes a mechanism that prevents the user from retracting the dial prior to rotating the dial to its zero dose position. This mechanism comprises a finger formed in the housing that rides within a groove formed at the distal end of the dial assembly as the dial assembly is rotated. The dial cannot be pulled out in any radial position other than the zero dose radial position due to the interference formed between the finger and the walls of the groove. In the zero dose position, the housing finger rides up within a spline that extends axially uninterrupted to enable the dial to be proximally retracted with respect to the housing only when the dial is in its zero dose radial position.
- The device includes a mechanism that limits the maximum dosage that can be set. This mechanism comprises a helical groove formed in the housing and a pair of flexible fingers formed in the dial assembly. Upon rotating the dial to set a dose, the dial is retracted with respect to the housing because the dial fingers ride up the internal housing groove. Once the dial fingers reach the proximal end of the housing groove, further rotation of the dial is prohibited, thereby indicating to the user that the maximum dosage has been dialed.
- The device further includes a mechanism for automatically locking out the dial from an inadvertent injection after the dial has been retracted to set a dosage. This lockout mechanism comprises the above-mentioned fingers in the dial assembly that fall into the helical groove in the housing upon retracting the dial with respect to the housing. The interference fit formed by the fingers in the groove prevents forward movement of the dial in the event of inadvertent pressure being applied to the end of the dial. The lockout mechanism is released by a button assembly that is disposed within the proximal end of the dial assembly. The button assembly is sized and configured so that it must be depressed upon initiating an injection. Upon depressing the button assembly, it bottoms out against the dial, whereupon the dial moves forwardly so that the flexible fingers move past the groove in the housing.
- One of the two flexible fingers of the dial assembly has an extension which, when the button is pressed, is pushed radially out. This finger falls within a separate groove in the housing as the "end-of-dose" stop surface of the dial engages the corresponding stop surface on the housing, thereby producing an audible "click" indicating that the entire dosage has been injected. The housing further includes radially inwardly extending tangs at the proximal end thereof which engage ratchet teeth in the leadscrew to prevent the leadscrew from backing up in the proximal direction. These tangs are in constant engagement with the leadscrew, thereby preventing the leadscrew from rotating upon rotation of the nut.
- The device also includes a mechanism which indicates to the user that there is an insufficient dosage remaining in the container of medication. This mechanism prevents the user from setting a dosage greater than that available to be delivered. The insufficient dose remaining feature comprises a 350° helical thread on the inner cylindrical surface of the nut and a raised finger forward at the end of the leadscrew where the external thread terminates. As the nut rotates about the leadscrew, the ledge formed by the termination of the helical thread on the nut engages the finger, thereby positively preventing further rotation of the nut in that direction.
- An advantage of the medication dispensing device of the present invention is that the dosing function is locked out until the dial has been rotated to its zero dose position, thereby ensuring an accurate dosage.
- Another advantage of the present invention is that the device is an inexpensive recyclable pen that is designed to allow a user to dose in single unit increments, which are each displayed in a single unit display.
- Another advantage of the present invention is that the end-of-dose click arrangement is adjacent the end-of-dose stop to provide increased accuracy of an end of dose.
- Another advantage of the present invention is that the device includes a dosage lockout mechanism that prevents an inadvertent delivery of a dosage of medication.
- A further advantage of the present invention is that the insufficient remaining dose mechanism comprises a radial stop which ensures that the user cannot dial up a dosage greater than that remaining in the cartridge.
- Yet another advantage of the present invention is that the device is made of inexpensive materials and is nearly 100% recyclable after the contents of the cartridge have been depleted.
- The present invention, in one form thereof, comprises an apparatus for effecting delivery of an injectable product. The apparatus comprises a housing and a container secured to the housing and including a piston, an exit, and an injectable product between the piston and the exit. A drive stem is disposed in the housing and is in engagement with the piston. The length of axial movement of the drive stem with respect to the housing between a pre-injection position and a post-injection position defines the stroke length of the drive stem. A manually adjustable dosage metering mechanism is disposed in the housing and is movable between a zero dose position, wherein the stroke length is zero, and a second dose position for enabling a user to selectively adjust the stroke length of the drive stem. The apparatus further includes means coupled to the dosage metering mechanism for preventing the stroke length of the drive stem from being adjusted until the dosage metering mechanism has been set to the zero dose position.
- In another form of the present invention, the apparatus includes a drive assembly mounted to the housing and manually advanceable in the housing between a dose setting position and an injection position for manually moving the drive stem to drive the piston within a container. The drive assembly is locked from movement with respect to the housing along the axis of ejection while in the dose setting position. A disengaging device is secured to at least one of the drive assembly and the housing to unlock the drive assembly from the housing to enable the drive assembly to be axially advanceable with respect to the housing to move the drive assembly from the dose setting position to the injection position.
- The present invention further includes a method of delivering a selected dosage of injectable product. The method includes the step of rotating a knob extending from an injector housing to establish a zero dose rotational position of the knob, wherein rotation of the knob causes rotation of the dial assembly attached to the knob. The knob and dial assembly are retracted while in the zero dose position to cause the dial assembly to engage an internally threaded nut with the housing. The knob is then rotated to cause rotation of the dial and the nut which causes axial translation of the dial and the nut, thereby setting a desired dosage of injectable product to be delivered. The knob is then manually depressed to depress the dial assembly and the nut and drive stem to cause the drive stem to advance the piston within the container of injectable product, thereby forcing a set dosage of injectable product to be delivered out of the exit of the container. The step of depressing the knob causes the dial assembly to become disengaged from the nut so that the knob may be rotated independently of the nut after delivery of the set dosage of injectable product has been completed.
- Fig. 1 is a perspective view of one embodiment of a medication dispensing device in accordance with the present invention;
- Fig. 2 is an exploded view of the device of Fig. 1;
- Fig. 3 is an enlarged longitudinal sectional view of a portion of the medication dispensing device of Fig. 1, particularly showing the button assembly disposed within dial assembly;
- Fig. 4 is an enlarged perspective view, in partial section, of the medication dispensing device of Fig. 1, particularly showing the button assembly disposed in the dial assembly;
- Fig. 5 is an enlarged cross sectional view of the medication dispensing device of Fig. 1, particularly showing the insufficient remaining dose stop on the nut approaching the corresponding stop on the leadscrew;
- Fig. 6 is a view of Fig. 5, except that the insufficient remaining dose stop on the nut is in engagement with the stop on the leadscrew;
- Fig. 7 is a perspective view, in partial section, of a housing part in engagement with the dial assembly, particularly showing the unit click finger in the zero position;
- Fig. 8 is a view of Fig. 7, except that the unit click finger is behind the end-of-dose flange;
- Fig. 9 is a view of Fig. 7, except that the unit click finger is shown in the dial splines during dosing;
- Fig. 10 is an enlarged sectional view of a portion of the medication dispensing device of Fig. 1, particularly showing the relationship among the button assembly, dial assembly, and housing while the device is at the end of dose position;
- Fig. 11 is a longitudinal sectional view of the medication dispensing device of Fig. 1, particularly showing the dial assembly after it has been rotated to the zero position;
- Fig. 12 is a view of Fig. 11 except that the dial assembly has been retracted so that the splines of the nut are engaged by the splines of the dial assembly;
- Fig. 13 is a view of Fig. 12, except that a desired dosage has been dialed up;
- Fig. 14 is a view similar to Fig. 10, showing the dial assembly rotated 180°, and further showing the button initially depressed before dial movement takes place;
- Fig. 15 is a view of Fig. 14, showing the dial having moved forward a small distance;
- Fig. 16 is a view of Fig. 14, showing the dial having moved forward half of a thread pitch; and
- Fig. 17 is a view of Fig. 13, except that the pen is shown in its end-of-dose position.
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- For purposes of this application, the term "proximal" shall designate a relative axial position toward the knob end of the delivery mechanism, and the term "distal" shall designate a relative axial position toward the delivery needle end of the delivery mechanism.
- Referring to Figs. 1 and 2, there is shown an
injection medication device 20 having the general appearance of a pen or mechanical pencil. The device comprises amechanism housing 22 having afirst part 24 and a second part 26 (Fig. 2).Housing parts cap 28 is snapped onto the distal end ofmechanism housing 22.Cap 28 includes aclip 30 which cooperates with the side wall ofcap 28 to provide a convenient means for holding thepen device 20 in a shirt pocket. Referring to Fig. 2, the major components ofmedication device 20 include abutton assembly 32, adial assembly 34, anut 36, and aleadscrew 38. Acartridge 40 is inserted into adistal body 42 to which is attached aneedle assembly 44 andneedle cover 46. All of the components ofmedication device 20, exceptcartridge 40 andneedle 44 may be made of a plastic material that is suitable for recycling. Suitable plastics are high flow polycarbonates resins which can be processed by conventional injection molding and extrusion. In one embodiment, thehousing parts distal body 42 are made from an optically clear polycarbonate material, and the remaining plastic components are made from ABS resins. These plastics are recyclable, thereby making disposal of the device environmentally desirable. - Referring to Fig. 4,
button assembly 32 comprises a hollowcylindrical portion 48 having aproximal end 50.Cylindrical portion 48 includes adistal end 52 in the form of an annular bead and further includes anenlarged diameter ring 54 comprising a taperedsurface 56 and an enlarged diameterflat surface 58. The inner section ofsurfaces diameter shoulder surface 60. Theproximal end 50 ofbutton assembly 32 comprises twoflexible fingers base surface 66. As shown in Fig. 4, eachfinger base surface 66 and is parallel with the axis ofmedical device 20, and a second leg extending radially about 90° from the first leg.Proximal end 50 ofbutton assembly 32 further includes a finger-engageable end 68 having a recessedsurface 70.End 68 is integrally connected to hollowcylindrical portion 48 by connection portions 72 (Fig. 3).Proximal end 68 includes a surface 74 (Fig. 3) that is formed from reducedlength portion 76. - Referring to Figs. 3 and 10,
dial assembly 34 is shown in detail.Dial assembly 34 is generally cylindrical in shape and is hollow throughout its axial length. The diameter ofdial assembly 34 is at a maximum at its proximal end and is at a minimum at its distal end. Referring to Fig. 3, dialassembly 34 comprises aproximal portion 78, anintermediate portion 80, and adistal portion 82.Proximal portion 78 comprises anenlarged diameter portion 84, a taperedportion 86, and an end-of-dose ring 91 extending about the circumference ofproximal portion 78 as shown in Fig. 3.Ring 91 includes a bottom surface 89 (Fig. 13) that constitutes a stop surface when engaged with the rear of the housing.Ring 91 also includes an enlarged "zero-dose"protrusion 88. A generally U-shaped groove 90 (Figs. 2, 3) is formed inproximal portion 78 to form aflexible section 92. The proximal inner surface offlexible section 92 includes afinger 94 having a taperedsurface 96 adapted for engagement with taperedsurface 56 ofbutton assembly 32 and a complimentary taperedsurface 98. -
Proximal portion 78 ofdial assembly 34 further includes a first U-shaped groove 100 (Fig. 2) and a second U-shaped groove (not shown) which formflexible legs leg finger finger finger 106 includes proximal taperedsurface 114, flat 116, and distal taperedsurface 118. Likewise,finger 108 includes proximal taperedsurface 120, flat 122, and distal taperedsurface 124. Outwardly extendingfinger 110 comprises a proximaltapered surface 126, a flat 128,shoulder 130, enlargeddiameter surface 132, and distal taperedsurface 134. Inwardly extendingfinger 112 includes a proximaltapered surface 136, ashoulder 138, anenlarged diameter surface 140, and a distal taperedsurface 142. - Referring to Fig. 3, a series of
axial splines 142 are arranged circumferentially about the inner surface ofdial assembly 34 at the area whereproximal portion 78 meetsintermediate portion 80. The circumferential array ofsplines 142 is interrupted bylegs splines 142 positioned about the inner circumference ofdial assembly 34. Referring to Figs. 3 and 10, there is shown a plurality ofsplines 144 extending circumferentially about the proximal interior surface ofintermediate portion 80 ofdial assembly 34. Unlikesplines 142,splines 144 extend 360° about the inner circumference ofintermediate portion 80. In one embodiment, eighteensplines 144 are positioned such that each spline is 20 circumferential degrees apart from an adjacent spline. - As best shown in Figs. 7-9,
distal portion 82 ofdial assembly 34 comprises aproximal flange 146, a reduceddiameter portion 148, and a distal end comprising a series ofelongated splines 150 extending externally about the circumference ofdistal portion 82.Splines 150 are in alignment withsplines 144. Therefore, in one embodiment, there are eighteensplines 150, each corresponding to arespective spline 144. As shown in Figs. 8 and 9, two of thesplines 150 extend axially into reduceddiameter portion 148. These extensions are indicated assplines 152. - Referring to Fig. 10,
housing parts proximal groove 154 having a taperedsurface 156.Housing parts helical spiral groove 158 and a taperedcircumferential surface 160 as shown in Fig. 10.Housing part 24 further includes asemicircular ridge 164 near the distal end thereof. Two grooves are formed at the distal portion ofhousing part 24 to define aflexible finger 166.Housing part 26 includes grooves formed therein to define aflexible leg 168 having an inwardly extendingfinger 170 at the end thereof.Finger 170 includes a proximaltapered surface 172 which terminates in a flat 174 and avertical edge 176.Housing parts transverse ledges Ledges flexible tangs - As best shown in Figs. 11-13 and 17,
medical delivery device 20 further includesnut 36 andleadscrew 38.Nut 36 is generally cylindrical in shape and includes a pair of axially extending grooves 186 (Fig. 2) to form resilientproximal legs 188. Eachleg 188 includes a proximal raisedportion 190 and two small axially extendingsplines 192. The distal end ofnut 36 comprises an enlarged gear-like member 194 having a plurality ofteeth 196 thereon. The interior surface of the distal end ofnut 36 includes ahelical thread 198.Thread 198 extends about 350° about the inner surface ofnut 36. A groove 200 is formed at the distal end ofleadscrew 138 to formlegs 226, 228 (Fig. 2). Ratchetteeth 204 are located on two opposing sides ofleadscrew 38 and axially extend along the length ofleadscrew 38 from groove 200 to the distal end, which constitutesplunger engagement portion 206.Helical threads 208 extend along the axial length ofleadscrew 36legs Leadscrew 38 fits within the cylindrical opening ofnut 36. - As shown in Figs. 11-14,
plunger engagement portion 206 ofleadscrew 38 is in engagement withpiston 210 ofcartridge 40.Cartridge 40 is housed withincartridge retainer 42, which is permanently secured tohousing parts Cartridge 40 is manufactured of glass and comprises a tube defining aninner chamber 212 which openly terminates at its distal end in aneck 214 having acap 216 including arubber disc 218 disposed thereover.Needle assembly 44 comprises an internally threadedbase 220 and adelivery needle 222. Internally threadedbase 220 is threaded onto externally threadeddistal portion 224 ofbody 42.Needle cap 46 fits overneedle 222 to prevent an inadvertent insertion ofneedle 222 into the patient.Cap 28 snaps ontocartridge body 42 to complete the pen-like mechanism. - In order to set a dose for injection, it is first necessary to manually zero the dial from the initial radial position of the dial resulting from the previous injection. The initial radial position of
dial assembly 34 with respect tohousing part 26 is shown in Fig. 8. Specifically,finger 170 ofhousing part 26 is located ingroove 148 ofdial assembly 34. Groove 148 can be rotated by rotatingdial assembly 34 with respect to the housing.Dial assembly 34 cannot be axially retracted due to the interference betweenvertical edge 176 ofhousing finger 170 andledge 149 ofdial assembly 34. Likewise, dialassembly 34 cannot be forced axially forwardly due to the interference betweensurface 89 onring 91 and end surfaces 33, 35 (Fig. 4) ofhousing parts button assembly 32 to pull out the dial,finger 94 falls into groove 154 (Fig. 10), thereby creating an interference that prevents the dial from being pulled out. Upon continued rotation ofdial assembly 34 with respect tohousing 26,splines 152 are moved into engagement withfinger 170, as shown in Fig. 7. This is the zero dose radial position ofdial assembly 34. This zero dose position is communicated to a user in four ways. The user hears a click assplines 152 engagefinger 170. The movement offinger 170 over thefirst spline 152 into the V-shapedrecess 155 betweensplines 152 causes a vibration indevice 20 that can be felt by the user. In addition,protrusion 88 ondial assembly 34 is in axial alignment withprotrusion 153 ofhousing part 24, thereby providing a visual indication that the zero dose position has been reached. This is further visually communicated by the presence of a symbol inlens 25. - A series of numerals (not shown) are printed on the surface of
intermediate portion 80 ofdial assembly 34. These numerals are helically spaced about the circumference ofportion 80 and may number from 1 to 60, in single increments, to indicate a desired dosage. Thelens 25 inhousing part 24 is aligned with the numbers so that the appropriate number appears in the lens upon dialing up the dosage. A raised rectangular portion lens 162 (Fig. 10) oflens 25 is located at the base oflens 25 to enhance the numerals thus making them easier to read. - In its zero dose position, dial
assembly 34 may be axially retracted a predetermined distance, e.g. 3 to 5 mm, as illustrated in Fig. 12. Asdial assembly 34 is retracted,ledge 149 is movedpast housing finger 170 resulting inhousing finger 170 being in engagement withsplines 150. In addition, splines 144 ofdial assembly 34 are moved into engagement withsplines 192 ofnut 36, as shown in Fig. 12. When engaged, rotation ofdial assembly 34 causes corresponding rotation ofnut 36. Rotation ofleadscrew 38 is prevented by a key-keyway type of engagement between theanti-backup tangs leadscrew 38. As shown in Fig. 6,tangs - Upon rotation of
dial assembly 34,fingers housing groove 158 in the proximal direction to retractdial 34, thereby increasing the axial distance betweenstop surface 89 ofring 91 and stopsurfaces housing parts dial assembly 34 causes rotation ofnut 36 so that internal helical raisedgroove 198 ofnut 36 rotates alongexternal threads 208 ofleadscrew 38 to causenut 36 to axially retract a corresponding axial distance. As shown in Fig. 9, rotation ofdial assembly 34causes splines 150 to movepast housing finger 170. The rotation of eachspline 150past finger 170 constitutes a single unit of dosage. As eachspline 150 moves pastfinger 170, it causes a "click" to occur, thereby providing an audible indication of each unit of dosage dialed up. In addition, a single numeral appears inlens 25 after each unit rotation indicating the current dose selected. Once a dosage has been selected, that dosage may be made larger or smaller by rotating the dial assembly in either the clockwise or counterclockwise direction. - In one embodiment, dial
assembly 34 includes eighteensplines 150 spaced 20° apart from one another. It is desired to limit the amount of dosage that can be dialed to prevent the entire contents ofcartridge 40 to be delivered at once. For example, it may be desirable to limit a measured dosage to a maximum of 60 units. If the dial assembly includes eighteen splines, this would mean that a user could rotate the dial assembly for nearly 3 1/2 rotations. As shown in Figs. 12 and 13, as a dosage is being set, outwardly extendingfingers dial assembly 34 ride inhelical groove 158 ofhousing parts fingers helical groove 158.Dial assembly 34 cannot be additionally rotated to further increase this maximum dosage due to an interference ledge at the end ofhelical groove 158.Button assembly 32 prevents thedial assembly 34 from being inadvertently pushed forwardly during the dosing process due to the interference betweenfingers dial assembly 34,button surface 52, andhelical spiral groove 158 inhousing parts Fingers groove 158 before the dial may be moved axially forwardly.Fingers groove 158 only after fullydepressing button assembly 32, thereby movingdistal button surface 52 out of engagement withfingers - Once a desired dosage has been set,
cap 28 is removed andneedle cover 46 is removed to exposeneedle 222. The needle is inserted into the patient, and recessedsurface 70 ofbutton assembly 32 is pushed. Figs. 14-16 illustrate the initial stages of the injection process. Referring to Fig. 14, asbutton surface 70 is pushed,button assembly 32 moves forwardly independently ofdial 34 until buttondistal surface 52 bottoms out againstinternal dial shoulder 141. Thereafter,button 32 and dial 34 are moved together. Referring to Fig. 15, asdial 34 begins to move forwardly, tapered finger surfaces 134, 142 are forced out of theirrespective threads 158. This causesfingers button 32 is further pressed,fingers respective threads 158, as shown in Fig. 16. Asbutton 32 continues to be pressed,fingers threads 158 in a like manner untildial 34 reaches its end of dose position shown in Figs. 10 and 17. The movement of edge 95 (Fig. 4) ofdial finger 94 past housing edge 157 (Fig. 4) and into groove 154 (Fig. 10) creates an audible "click" sound, thereby providing an audible confirmation that the entire dosage has been injected.Finger 94 is in close proximity to stopsurfaces - As
dial 34 is initially moved forwardly, splines 144 move out of engagement withsplines 192 ofnut 36 to decoupledial 34 fromnut 36 prior to any axial movement ofnut 36.Dial 34 moves axially with respect tonut 36 until the distal end 193 (Fig. 13) ofdial 34 engagesnut flange 194 and movesnut 36 andleadscrew 38 forwardly to deliver the set dosage of fluid. - Referring to Figs. 10 and 17, forward movement of
dial assembly 34 andnut 36 is limited by the engagement ofsurface 89 ofring 91 with proximal end surfaces 33, 35 ofhousing parts flange 194 andinternal ledges housing parts nut flange 194 andledges - Movement of
leadscrew 38 is prevented in the proximal direction due toanti-backup tangs ratchet teeth 204. This assures thathead 206 ofleadscrew 38 remains at all times in constant engagement withpiston 210. - Once a dosage has been completed, the user releases his finger from recessed
button surface 70. Upon releasing pressure fromsurface 70, the flexible fingers or springs 62, 64 return from their stressed conditions back to their relaxed conditions, thereby automatically retracting thebutton assembly 32 back to the automatic lockout position shown in Fig. 11 to prevent thedial assembly 34 from being inadvertently advanced when it is again moved to its retracted position. -
Medication device 20 further includes a mechanism to indicate to the user that there is an insufficient dosage ofmedication 212 remaining incartridge 40. Referring to Figs. 5 and 6,leadscrew 38 comprises twolegs Leg 226 may be of a greater thickness thanleg 228.Leg 226 includes an axially extending raisedledge 230 at the end ofexternal thread 208.Leg 228 contains theend 232 ofexternal thread 208. The internalhelical thread 198 ofnut 36 defines astop surface 234 due to the fact thatthread 198 extends less than 360° in circumference. As shown in Fig. 17,nut 36 moves towardlegs leadscrew 38 asleadscrew 38 moves withincartridge 40. Oncenut 36 has axially moved entirely alongthread 208 ofleadscrew 38, stop 234 approachesaxial ledge 230, as shown in Fig. 5. Additional rotation ofnut 36 results instop 234 engagingledge 230, as shown in Fig. 6. This prevents the user from dialing up a higher dosage.Nut 36 may be rotated back in the opposite direction to reduce the dosage if desired. This rotational stop mechanism provides a very accurate indication to the user of the dosage remaining in the cartridge.
Claims (13)
- An apparatus (20) for the delivery of an injectable product, comprising:a housing (22);a container (40) mounted within said housing (22) and including a piston (210), an exit and an injectable product between said piston (210) and said exit, wherein movement of said piston (210) toward the exit defines an axis of ejection of the injectable product from the container (4); anda drive stem (38) disposed in said housing (22) and drivingly coupled to said piston (210),a drive assembly (34) mounted to said housing (22) and manually axially advanceable in said housing (22) between a dose-setting position and an injection position for manually moving said drive stem (38) to drive said piston (210) within said container (40), said drive assembly (34) being locked from movement with respect to said housing (22) along the axis of ejection while in said dose setting position; anda disengaging device (32) secured to at least one of said drive assembly (34) and said housing (22) and manually actuable to unlock said drive assembly (34) from said housing (22) to enable said drive assembly (34) to be axially advanceable with respect to said housing (22) to move said drive assembly (34) from said dose setting position to said injection position, said apparatus characterized by:means (182,184,204) for maintaining said drive stem in engagement with said piston.
- The apparatus (20) of Claim 1, wherein said drive assembly (34) is characterized by a generally cylindrical dial (34) that is telescopingly disposed within said housing (22), said dial (34) having a flexible finger (110,112) formed therein that engages an internal groove (158) in said housing (22) while said drive assembly (34) is in said dose-setting position to form an interference fit therebetween, thereby preventing axial movement of said drive assembly (34) with respect to said housing (22).
- The apparatus (20) of Claim 2, wherein said disengaging device (32) is characterized by a generally cylindrical button (32) that is telescopingly disposed within said dial (34), said button (32) including an enlarged diameter portion (54), which when advanced, disengages said flexible finger (110, 112) of said dial (34) to allow said finger (110, 112) to move out of engagement with said groove (158) in said housing (22) to enable said drive assembly to be axially advanced with respect to the housing (22).
- The apparatus (20) of Claim 1 characterized in that said drive assembly includes a driver (34) for driving said drive stem (38), said driver (34) being locked from axial movement with respect to said housing (22) while in said dose-setting position and a manually adjustable dosage metering mechanism (34) disposed in said housing (22) and movable between a zero dose position, wherein the stroke length is zero, and a second dose position for enabling a user to selectively adjust the stroke length of said drive stem (38), and said disengaging device (32) includes said driver (34) and an unlocking mechanism (32) disposed in said housing (22) and positioned to unlock said driver (34) upon initiation of an injection to enable said drive stem (38) to move from said dose-setting position to said post-injection position.
- The apparatus (20) of Claim 4, wherein a length of axial movement of said drive stem (38) with respect to said housing (22) between a pre-injection position and a post-injection position defines a stroke length of said drive stem (38), and wherein said dose setting assembly (34) is rotatable between a zero dose position, wherein the stroke length is zero, and a second dose position for enabling a user to selectively adjust the stroke length of said drive stem (38).
- An apparatus (20) for the delivery of an injectable product, comprising:a housing (22);a container (40) mounted within said housing (22) and including a piston (210), an exit and an injectable product between said piston (210) and said exit, wherein movement of said piston (210) toward the exit defines an axis of ejection of the iniectable product from the container (40); anda drive stem (38) disposed in said housing (22) and drivingly coupled to said piston (210); said apparatus characterized by:a drive assembly (34) mounted to said housing (22) and manually axially advanceable in said housing (22) between a dose-setting position and an injection position for manually moving said drive stem (38) to drive said piston (210) within said container (40), said drive assembly (34) being locked from movement with respect to said housing (22) along the axis of ejection while in said dose setting position; anda disengaging device (32) secured to at least one of said drive assembly (34) and said housing (22) and manually actuable to unlock said drive assembly (34) from said housing (22) to enable said drive assembly (34) to be axially advanceable with respect to said housing (22) to move said drive assembly (34) from said dose setting position to said injection position.
- The apparatus (20) of Claim 6, wherein said drive assembly (34) is characterized by a generally cylindrical dial (34) that is telescopingly disposed within said housing (22), said dial (34) having a flexible finger (110,112) formed therein that engages an internal groove (158) in said housing (22) while said drive assembly (34) is in said dose-setting position to form an interference fit therebetween, thereby preventing axial movement of said drive assembly (34) with respect to said housing (22).
- The apparatus (20) of Claim 7, wherein said disengaging device (32) is characterized by a generally cylindrical button (32) that is telescopingly disposed within said dial (34), said button (32) including an enlarged diameter portion (54), which when advanced, disengages said flexible finger (110, 112) of said dial (34) to allow said finger (110, 112) to move out of engagement with said groove (158) in said housing (22) to enable said drive assembly to be axially advanced with respect to the housing (22).
- The apparatus (20) of Claim 6 characterized in that said drive assembly includes a driver (34) for driving said drive stem (38), said driver (34) being locked from axial movement with respect to said housing (22) while in said dose-setting position and a manually adjustable dosage metering mechanism (34) disposed in said housing (22) and movable between a zero dose position, wherein the stroke length is zero, and a second dose position for enabling a user to selectively adjust the stroke length of said drive stem (38), and said disengaging device (32) includes said driver (34) and an unlocking mechanism (32) disposed in said housing (22) and positioned to unlock said driver (34) upon initiation of an injection to enable said drive stem (38) to move from said dose-setting position to said post-injection position.
- The apparatus (20) of Claim 6, characterized in that said drive stem (38) is in continuous engagement with said piston (210), wherein a length of axial movement of said drive stem (38) with respect to said housing (22) between a pre-injection position and a post-injection position defines a stroke length of said drive stem (38), and wherein said dose setting assembly (34) is rotatable between a zero dose position, wherein the stroke length is zero, and a second dose position for enabling a user to selectively adjust the stroke length of said drive stem (38).
- An apparatus (20) for effecting delivery of an injectable product, comprising:a housing (22); anda container (40) secured to said housing (22) and including a piston (210), an exit and an injectable product between said piston and said exit; said apparatus characterized by:an externally threaded drive stem (38) disposed in said housing (22) and drivingly coupled to said piston (210); an internally threaded nut (36) disposed about said drive stem (38);a dial assembly (34) disposed in said housing (22) and coupled to said nut (36) such that rotation of said dial assembly (34) causes rotation of said nut (36) with respect to said drive stem (38) to set a desired dosage of injectable product to be delivered; andmeans (234) on at least one of said nut (36) and said drive stem (38) for preventing rotation of said nut (36) with respect to said drive stem (38) as said nut (36) engages an end (230) of an external threaded surface (208) of said drive stem (210), thereby providing an indication to a user that an insufficient dosage of injectable product remains in said container (40).
- A method of delivering a selected dosage of injectable product, the method characterized by the steps of:rotating a knob (78) extending from an injector housing (22) to establish a zero dose rotational position of said knob (78), wherein rotation of the knob (78) causes rotation of a dial assembly (34) attached to the knob (78);retracting the knob (78) and dial assembly (34) while in the zero dose position to cause the dial assembly (34) to engage an internally threaded nut (36) with the housing (22);rotating the knob (78) thereby causing rotation of the nut (36) to cause axial translation of the nut (36) along an externally threaded drive stem (38) that is received within the nut (36), thereby setting a desired dosage of injectable product to be delivered; andmanually depressing the knob (78) to manually depress the dial assembly (34) and the nut (36) and drive stem (38) to cause the drive stem (38) to advance a piston (210) within a container (40) of injectable product, thereby forcing the set dosage of injectable product to be delivered out of an exit of the container (40), wherein the step of depressing the knob (78) causes the dial assembly (34) to become disengaged from the nut (36) so that the knob (78) may be rotated independent of the nut (36) after delivery of the set dosage of injectable product has been completed.
- A method of Claim 12 further characterized by the steps of:actuating an unlocking mechanism (54) which unlocks said locking mechanism (110, 112) to enable the knob (78) and dial assembly (34) to be manually advanced, thereby causing translation of the nut (36) and drive stem (38) to cause the drive stem (38) to advance a piston (210) within a container (40) of injectable product, thereby forcing the set dosage of injectable product to be delivered out of an exit of the container (40), wherein the step of depressing the knob (78) and initial advancement of the dial assembly (34) causes the dose setting mechanism (34) to become disengaged from the nut (36) so that the knob may be rotated independent of the nut (36) after delivery of the set dosage of injectable product has been completed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US39976495A | 1995-03-07 | 1995-03-07 | |
US399764 | 1995-03-07 | ||
EP98202729A EP0879610B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing divice |
EP96301540A EP0730876B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing device |
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Application Number | Title | Priority Date | Filing Date |
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EP98202729A Division EP0879610B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing divice |
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EP1304129A2 true EP1304129A2 (en) | 2003-04-23 |
EP1304129A3 EP1304129A3 (en) | 2005-11-23 |
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EP03001272A Withdrawn EP1304129A3 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing device |
EP96301540A Expired - Lifetime EP0730876B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing device |
EP98202729A Expired - Lifetime EP0879610B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing divice |
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Application Number | Title | Priority Date | Filing Date |
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EP96301540A Expired - Lifetime EP0730876B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing device |
EP98202729A Expired - Lifetime EP0879610B1 (en) | 1995-03-07 | 1996-03-06 | Recyclable medication dispensing divice |
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US (3) | US6001089A (en) |
EP (3) | EP1304129A3 (en) |
JP (2) | JP3568959B2 (en) |
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AU (1) | AU696439B2 (en) |
CA (1) | CA2213682C (en) |
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PT (2) | PT879610E (en) |
SI (2) | SI0730876T1 (en) |
WO (1) | WO1996027400A1 (en) |
ZA (1) | ZA961845B (en) |
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US8333739B2 (en) | 2000-06-16 | 2012-12-18 | Novo Nordisk A/S | Injection device |
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US11426525B2 (en) | 2009-06-02 | 2022-08-30 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
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US9629962B2 (en) | 2009-06-02 | 2017-04-25 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
US11324894B2 (en) | 2009-06-02 | 2022-05-10 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
US11167093B2 (en) | 2009-06-02 | 2021-11-09 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
WO2010139691A1 (en) * | 2009-06-02 | 2010-12-09 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
US10286154B2 (en) | 2009-06-02 | 2019-05-14 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
US10806865B2 (en) | 2009-10-16 | 2020-10-20 | Owen Mumford Limited | Injector apparatus having a clutch to inhibit forward movement of the plunger |
US11819668B2 (en) | 2009-10-16 | 2023-11-21 | Owen Mumford Limited | Injector apparatus having a clutch to inhibit forward movement of the plunger |
US11033690B2 (en) | 2009-10-16 | 2021-06-15 | Owen Mumford Limited | Injector apparatus having a clutch to inhibit forward movement of the plunger |
US8333525B2 (en) | 2010-11-19 | 2012-12-18 | Msd Consumer Care, Inc. | Click pen applicator device and method of using same |
US8328449B2 (en) | 2010-11-19 | 2012-12-11 | Msd Consumer Care, Inc. | Click pen applicator device and method of using same |
US9901685B2 (en) | 2012-01-27 | 2018-02-27 | Novo Nordisk A/S | Injection device with a sliding scale |
EP2806925B1 (en) | 2012-01-27 | 2016-01-13 | Novo Nordisk A/S | Injection device with a sliding scale |
US10850043B2 (en) | 2013-04-10 | 2020-12-01 | Sanofi | Injection device |
US10004852B2 (en) | 2013-04-10 | 2018-06-26 | Sanofi | Injection device |
US9987429B2 (en) | 2013-07-17 | 2018-06-05 | Sanofi | Display assembly and dispensing device |
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