EP1334356A4 - Method for generating cloned animals using chromosome shuffling - Google Patents

Method for generating cloned animals using chromosome shuffling

Info

Publication number
EP1334356A4
EP1334356A4 EP01981389A EP01981389A EP1334356A4 EP 1334356 A4 EP1334356 A4 EP 1334356A4 EP 01981389 A EP01981389 A EP 01981389A EP 01981389 A EP01981389 A EP 01981389A EP 1334356 A4 EP1334356 A4 EP 1334356A4
Authority
EP
European Patent Office
Prior art keywords
animals
isogenic
chromosome
cloned
autosomally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01981389A
Other languages
German (de)
French (fr)
Other versions
EP1334356A2 (en
Inventor
Robert Lanza
Jose Cibelli
Philip Damiani
Michael D West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Institute for Regenerative Medicine
Original Assignee
Advanced Cell Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Technology Inc filed Critical Advanced Cell Technology Inc
Publication of EP1334356A2 publication Critical patent/EP1334356A2/en
Publication of EP1334356A4 publication Critical patent/EP1334356A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0273—Cloned animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Abstract

The present invention concerns the use of chromosomal replacement techniques in the context of producing cloned and transgenic animals, in order to correct chromosome abnormalities or alter autosomal genotypes, and provide for novel breeding pairs by replacing the sex chromosome in animals to be cloned. Replacement of a sex chromosome, or an X or Y chromosome, will result in animals that are autosomally isogenic and sexually non-isogenic (AISN), with 'autosomally isogenic' meaning that the paired sets of autosomes (non-sex chromosomes) in each animal are isogenic or identical. Also included in the invention are animals that are both 'autosomally' and 'allelically' isogenic whereby each particular pair of chromosomes is internally isogenic or identical within a single animal as well as between animals. Such animals are particularly useful in generating a line of cloned mammals using sexual reproduction, without having the undergo nuclear transfer in order to propagate cloned animals.
EP01981389A 2000-10-06 2001-10-05 Method for generating cloned animals using chromosome shuffling Withdrawn EP1334356A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23801400P 2000-10-06 2000-10-06
US238014P 2000-10-06
PCT/US2001/031216 WO2002029002A2 (en) 2000-10-06 2001-10-05 Method for generating cloned animals using chromosome shuffling

Publications (2)

Publication Number Publication Date
EP1334356A2 EP1334356A2 (en) 2003-08-13
EP1334356A4 true EP1334356A4 (en) 2004-10-06

Family

ID=22896126

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01981389A Withdrawn EP1334356A4 (en) 2000-10-06 2001-10-05 Method for generating cloned animals using chromosome shuffling

Country Status (4)

Country Link
EP (1) EP1334356A4 (en)
AU (1) AU2002213033A1 (en)
CA (1) CA2425100A1 (en)
WO (1) WO2002029002A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10248361A1 (en) * 2002-06-30 2004-01-22 Beisswanger, Roland, Dr. Method for suppressing the male sex in birds, specifically in laying poultry, by inserting a lethal DNA sequence into sex chromosomes that is active only in male embryos
CN114457360B (en) * 2022-02-11 2023-08-25 中国华能集团清洁能源技术研究院有限公司 Diaphragm-free micro-electrolytic tank amplifying equipment, processing method and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240840A (en) * 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
WO1999037143A2 (en) * 1998-01-21 1999-07-29 University Of Hawaii Full term development of animals from enucleated oocytes reconstituted with adult somatic cell nuclei
WO2000042174A1 (en) * 1999-01-13 2000-07-20 Ppl Therapeutics (Scotland) Limited Double nuclear transfer method and results thereof
WO2002077175A2 (en) * 2001-03-23 2002-10-03 Advanced Cell Technology, Inc. Method for generating cloned animals using chromosome shuffling

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270201A (en) * 1988-03-24 1993-12-14 The General Hospital Corporation Artificial chromosome vector
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240840A (en) * 1991-04-05 1993-08-31 Regents Of The University Of Michigan Dna superfragment cloning
WO1999037143A2 (en) * 1998-01-21 1999-07-29 University Of Hawaii Full term development of animals from enucleated oocytes reconstituted with adult somatic cell nuclei
WO2000042174A1 (en) * 1999-01-13 2000-07-20 Ppl Therapeutics (Scotland) Limited Double nuclear transfer method and results thereof
WO2002077175A2 (en) * 2001-03-23 2002-10-03 Advanced Cell Technology, Inc. Method for generating cloned animals using chromosome shuffling

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"CAN CLONING SAVE ENDANGERED SPECIES?", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 11, no. 7, 2000, pages R245 - R246, XP002909800, ISSN: 0960-9822 *
BOURHIS LE D ET AL: "NUCLEAR TRANSFER FROM SEXED PARENT EMBRYOS IN CATTLE: EFFICIENCY AND BIRTH OF OFFSPRING", JOURNAL OF REPRODUCTION AND FERTILITY, JOURNALS OF REPRODUCTION AND FERTILITY LTD, GB, vol. 113, no. 2, July 1998 (1998-07-01), pages 343 - 348, XP000922632, ISSN: 0022-4251 *
WHITE K L ET AL: "ESTABLISHMENT OF PREGNANCY AFTER THE TRANSFER OF NUCLEAR TRANSFER EMBRYOS PRODUCED FROM THE FUSION OF ARGALI (OVIS AMMON) NUCLEI INTO DOMESTIC SHEEP (OVIS ARIES) ENUCLEATED OOCYTES", CLONING, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 1, no. 1, 1999, pages 47 - 54, XP002909799, ISSN: 0737-1454 *
WOLF E ET AL: "Nuclear transfer in mammals: Recent developments and future perspectives", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 65, no. 2-3, 27 October 1998 (1998-10-27), pages 99 - 110, XP004144916, ISSN: 0168-1656 *

Also Published As

Publication number Publication date
WO2002029002A2 (en) 2002-04-11
EP1334356A2 (en) 2003-08-13
WO2002029002A3 (en) 2002-09-19
CA2425100A1 (en) 2002-04-11
AU2002213033A1 (en) 2002-04-15

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 01K 67/027 A

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WEST, MICHAEL, D.

Inventor name: DAMIANI, PHILIP

Inventor name: CIBELLI, JOSE

Inventor name: LANZA, ROBERT

A4 Supplementary search report drawn up and despatched

Effective date: 20040824

17Q First examination report despatched

Effective date: 20070801

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20071212