EP1742058A3 - Substrate for analyte determination and methods for manufacturing such substrates - Google Patents

Substrate for analyte determination and methods for manufacturing such substrates Download PDF

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Publication number
EP1742058A3
EP1742058A3 EP06020037A EP06020037A EP1742058A3 EP 1742058 A3 EP1742058 A3 EP 1742058A3 EP 06020037 A EP06020037 A EP 06020037A EP 06020037 A EP06020037 A EP 06020037A EP 1742058 A3 EP1742058 A3 EP 1742058A3
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EP
European Patent Office
Prior art keywords
matrix
manufacturing
substrates
substrate
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06020037A
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German (de)
French (fr)
Other versions
EP1742058B1 (en
EP1742058A2 (en
Inventor
Cord F. Stähler
Peer F. Stähler
Manfred Müller
Fritz Dr. Stähler
Hans Lindner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Febit Holding GmbH
Original Assignee
Febit Holding GmbH
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Application filed by Febit Holding GmbH filed Critical Febit Holding GmbH
Publication of EP1742058A2 publication Critical patent/EP1742058A2/en
Publication of EP1742058A3 publication Critical patent/EP1742058A3/en
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
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    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00704Processes involving means for analysing and characterising the products integrated with the reactor apparatus
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    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709Type of synthesis
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
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    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0654Lenses; Optical fibres
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
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    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
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    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S435/97Test strip or test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/973Simultaneous determination of more than one analyte

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Abstract

An electronically-controlled light source matrix (3), preferably a liquid crystal display (LCD) matrix, is faced by a light sensor matrix (9), preferably a charge coupled display (CCD) image sensor. This detects optical behavior of a substance (7) sandwiched between them. Preferred Features: In a related concept, an LCD matrix produces two-dimensional lighting patterns in manufacturing or examination.
EP06020037A 1998-08-28 1999-08-27 Substrate for analyte determination and methods for manufacturing such substrates Expired - Lifetime EP1742058B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19839254 1998-08-28
DE19839255 1998-08-28
DE19839256 1998-08-28
DE19907080 1999-02-19
DE19924327 1999-05-27
EP99944538A EP1117478B1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support
EP03028140A EP1405666B1 (en) 1998-08-28 1999-08-27 Substrate for methods to determine analytes and methods to manufacture such substrates

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
EP03028140A Division EP1405666B1 (en) 1998-08-28 1999-08-27 Substrate for methods to determine analytes and methods to manufacture such substrates
EP99944538.0 Division 1999-08-27
EP03028140.6 Division 2003-12-05

Publications (3)

Publication Number Publication Date
EP1742058A2 EP1742058A2 (en) 2007-01-10
EP1742058A3 true EP1742058A3 (en) 2008-12-10
EP1742058B1 EP1742058B1 (en) 2011-11-30

Family

ID=27512654

Family Applications (6)

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EP10176218A Withdrawn EP2273270A1 (en) 1998-08-28 1999-08-27 Method and apparatus for the preparation and/or analysis of biochemical carriers
EP99968261A Expired - Lifetime EP1117996B1 (en) 1998-08-28 1999-08-27 Method for producing biochemical reaction supporting materials
EP03028140A Revoked EP1405666B1 (en) 1998-08-28 1999-08-27 Substrate for methods to determine analytes and methods to manufacture such substrates
EP99942927A Withdrawn EP1115424A1 (en) 1998-08-28 1999-08-27 Method and measuring device for determining a plurality of analytes in a sample
EP06020037A Expired - Lifetime EP1742058B1 (en) 1998-08-28 1999-08-27 Substrate for analyte determination and methods for manufacturing such substrates
EP99944538A Expired - Lifetime EP1117478B1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support

Family Applications Before (4)

Application Number Title Priority Date Filing Date
EP10176218A Withdrawn EP2273270A1 (en) 1998-08-28 1999-08-27 Method and apparatus for the preparation and/or analysis of biochemical carriers
EP99968261A Expired - Lifetime EP1117996B1 (en) 1998-08-28 1999-08-27 Method for producing biochemical reaction supporting materials
EP03028140A Revoked EP1405666B1 (en) 1998-08-28 1999-08-27 Substrate for methods to determine analytes and methods to manufacture such substrates
EP99942927A Withdrawn EP1115424A1 (en) 1998-08-28 1999-08-27 Method and measuring device for determining a plurality of analytes in a sample

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP99944538A Expired - Lifetime EP1117478B1 (en) 1998-08-28 1999-08-27 Support for a method for determining an analyte and a method for producing the support

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US (5) US7097974B1 (en)
EP (6) EP2273270A1 (en)
JP (3) JP2002525590A (en)
AT (4) ATE357289T1 (en)
AU (3) AU771238B2 (en)
CA (2) CA2341894A1 (en)
DE (8) DE59914270D1 (en)
WO (3) WO2000012123A2 (en)

Families Citing this family (242)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6426184B1 (en) 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US7101914B2 (en) 1998-05-04 2006-09-05 Natural Asa Isomer enriched conjugated linoleic acid compositions
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US7097974B1 (en) 1998-08-28 2006-08-29 Febit Biotech Gmbh Support for a method for determining an analyte and a method for producing the support
NZ511560A (en) * 1998-11-05 2002-11-26 Chemometec As A method for the assessment of particles and a system and a device for use in the method
EP1728860B1 (en) 1999-02-19 2010-01-27 febit holding GmbH Method for producing polymers
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US20050279949A1 (en) 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
ATE264718T1 (en) * 1999-07-02 2004-05-15 Clondiag Chip Tech Gmbh MICROCHIP MATRIX DEVICE FOR THE DUPLICATION AND CHARACTERIZATION OF NUCLEIC ACIDS
JP2001078175A (en) * 1999-07-07 2001-03-23 Fuji Photo Film Co Ltd Fluorescent observation device
JP2001070227A (en) 1999-07-07 2001-03-21 Fuji Photo Film Co Ltd Fluorescent observing device
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US20050164293A1 (en) * 1999-11-29 2005-07-28 Peer Stahler Dynamic determination of analytes
DE19962803A1 (en) * 1999-12-23 2001-07-05 Basf Ag Process and device for mask-free production of biopolymers
DE10024132B4 (en) * 2000-01-28 2007-03-22 Leica Microsystems Cms Gmbh Arrangement for detecting fluorescent light of several sample points
DE10013254A1 (en) * 2000-03-17 2001-10-04 Friz Biochem Gmbh New apparatus, useful for detecting biomolecules and polymers, comprises array of samples containing specific molecules with separate light sources and system for detecting which samples interact with molecule to be detected
CA2404799C (en) 2000-04-06 2007-08-07 Conlinco, Inc. Conjugated linoleic acid compositions
EP1274320A2 (en) 2000-04-18 2003-01-15 Natural AS Conjugated linoleic acid powder
DE10023423B4 (en) * 2000-05-12 2009-03-05 Gnothis Holding Sa Direct detection of single molecules
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7892854B2 (en) * 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001271893A1 (en) * 2000-07-07 2002-01-21 Nimblegen Systems, Inc. Method and apparatus for synthesis of arrays of dna probes
DE10036457A1 (en) * 2000-07-26 2002-02-14 Giesing Michael Use of an imaging photoelectric area sensor for evaluating biochips and imaging processes therefor
US6576472B1 (en) * 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
FR2813121A1 (en) * 2000-08-21 2002-02-22 Claude Weisbuch PERFECTED DEVICE FOR SUPPORTING CHROMOPHORIC ELEMENTS
ATE303863T1 (en) * 2000-10-17 2005-09-15 Febit Ag METHOD AND DEVICE FOR INTEGRATED SYNTHESIS AND ANALYTE DETERMINATION ON A SUPPORT
DE10051396A1 (en) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
DE10058095C2 (en) * 2000-11-03 2003-12-18 Fraunhofer Ges Forschung Device for the determination of analytes by chemiluminescence
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
DE10060433B4 (en) * 2000-12-05 2006-05-11 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Method for producing a fluid component, fluid component and analysis device
DE10062244A1 (en) * 2000-12-14 2002-07-04 Infineon Technologies Ag Sensor for the detection of macromolecular biopolymers, sensor arrangement, method for the detection of macromolecular biopolymers and method for producing a sensor for the detection of macromolecular biopolymers
DE10103954B4 (en) 2001-01-30 2005-10-06 Advalytix Ag Method for analyzing macromolecules
DE10113711A1 (en) * 2001-03-16 2002-09-26 Lifebits Ag Identifying bio-chemical reactions e.g., DNA hybridization, comprises digitally scanning specific detector molecules in an array of accurately-defined and discrete points with a sample, for statistical evaluation
DE10115474A1 (en) * 2001-03-29 2002-10-10 Infineon Technologies Ag Microfluid channel structure used for carrying out chemical, biological and/or physical processes comprises channel sections arranged in series with a microchannel between connections in the flow direction of the medium
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
US20020160427A1 (en) * 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes
DE10122357A1 (en) * 2001-05-09 2002-11-14 Febit Ferrarius Biotech Gmbh Hybrid process for the production of supports for analyte determination
CA2452693A1 (en) 2001-06-06 2002-12-12 Digital Optical Imaging Corporation Light modulated microarray reader and methods relating thereto
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
DE10156329A1 (en) * 2001-07-17 2003-02-06 Frieder Breitling Method and arrangement for attaching substances immobilized in transport means as well as monomer particles
DE10133844B4 (en) * 2001-07-18 2006-08-17 Micronas Gmbh Method and device for detecting analytes
DE10136008B4 (en) * 2001-07-24 2005-03-31 Advalytix Ag Method for analyzing macromolecules and method for producing an analysis device
DE10142691B4 (en) * 2001-08-31 2006-04-20 Infineon Technologies Ag Method for detecting biochemical reactions and a device therefor
EP1432786B1 (en) 2001-09-06 2009-07-22 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
DE10145700A1 (en) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip arrangement, sensor arrangement and method for operating a biochip arrangement
DE10145701A1 (en) * 2001-09-17 2003-04-10 Infineon Technologies Ag Fluorescence biosensor chip and fluorescence biosensor chip arrangement
DE10148102B4 (en) * 2001-09-28 2006-03-30 Biotez Berlin-Buch Gmbh Biochip for the quantitative photometric detection of biomolecules, its use and method for the quantitative detection of biomolecules by photometric detection of a color reaction
DE10149947A1 (en) 2001-10-10 2003-04-17 Febit Ferrarius Biotech Gmbh Isolating target molecules, useful for separating e.g. nucleic acids for therapy or diagnosis, comprises passing the molecules through a microfluidics system that carries specific receptors
KR20040068122A (en) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
DE10152925A1 (en) * 2001-10-26 2003-05-08 Febit Ag Asymmetric probes
US7413859B2 (en) 2001-11-14 2008-08-19 Siemens Aktiengesellschaft Method and biosensors for detecting macromolecular biopolymers
DE10155892A1 (en) * 2001-11-14 2003-05-28 Infineon Technologies Ag To identify macromolecular biopolymers, catch molecules are immobilized on a biosensor surface to form complexes with the macromolecular biopolymer in the sample for identification by signal intensity
DE10156467A1 (en) * 2001-11-16 2003-06-05 Micronas Gmbh Carriers for synthesis and processes for the production of biopolymers
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10160987B4 (en) * 2001-12-05 2005-08-04 Siemens Ag Assembly for simultaneous, optical illumination of a large number of samples
DE10201463B4 (en) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaction vessel for performing array method
DE10206548B4 (en) * 2002-02-13 2005-06-16 Siemens Ag Method for the analysis of support components carrying sample components and devices for carrying out this method
DE10208770A1 (en) * 2002-02-28 2003-09-04 Febit Ag Increasing the sensitivity and specificity of hybridization experiments with nucleic acid chips
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
DE10215319A1 (en) * 2002-04-02 2003-10-30 Siemens Ag Light source, for examination of sample on glass slide, is illuminated by array of light emitting diodes via lens system for charge coupled device camera
EP2775291B1 (en) 2002-05-17 2016-01-13 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
DE10224825A1 (en) * 2002-06-05 2003-12-24 Eppendorf Ag Methods for the analysis of biomolecules
FR2842826B1 (en) * 2002-07-25 2006-01-20 Centre Nat Rech Scient PROCESS FOR PRODUCING BIOLOGICAL CHIPS
JP2004069559A (en) 2002-08-07 2004-03-04 Seiko Epson Corp Manufacturing system, its controller, controlling method, controlling system, and control program
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
DE10242530A1 (en) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Light source, for measurement system based on photosensitive electrode, illuminates electrode locally for detection of one or more analytes
DE10242529A1 (en) * 2002-09-12 2004-03-25 Forschungszentrum Jülich GmbH Portable optical system using photosensitive electrode to analyze one or more substances, includes light sources inside analysis container
US7469076B2 (en) 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US6743931B2 (en) 2002-09-24 2004-06-01 Natural Asa Conjugated linoleic acid compositions
DE10245432A1 (en) * 2002-09-27 2004-04-08 Micronas Gmbh Method and device for detecting at least one luminescent substance
DE10245845B4 (en) * 2002-09-30 2006-06-29 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Measuring chip for the use of a device for the quantitative determination of an analyte in a sample and device with this measuring chip
US7305112B2 (en) * 2002-10-15 2007-12-04 The Scripps Research Institute Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7220592B2 (en) * 2002-11-15 2007-05-22 Eksigent Technologies, Llc Particulate processing system
US7175810B2 (en) 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
DE50310049D1 (en) * 2002-12-23 2008-08-07 Febit Biotech Gmbh INSTALLATION OF HAPTEN GROUPS IN THE MANUFACTURE OF SUPPORTS FOR ANALYTICAL ASSESSMENT
EP1596978A2 (en) * 2002-12-23 2005-11-23 febit biotech GmbH Method for the validated construction of arrays
DE10312670A1 (en) * 2003-03-21 2004-10-07 Friz Biochem Gmbh Substrate for controlled wetting of predetermined wetting points with small liquid volumes, substrate cover and flow chamber
EP1625386B8 (en) * 2003-03-24 2021-07-28 Intuity Medical, Inc. Analyte concentration detection devices and methods
US7300755B1 (en) * 2003-05-12 2007-11-27 Fred Hutchinson Cancer Research Center Methods for haplotyping genomic DNA
JP2004361158A (en) * 2003-06-03 2004-12-24 Moritex Corp Biochemistry detection apparatus detection method
US8133670B2 (en) 2003-06-13 2012-03-13 Cold Spring Harbor Laboratory Method for making populations of defined nucleic acid molecules
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050209787A1 (en) * 2003-12-12 2005-09-22 Waggener Thomas B Sequencing data analysis
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
DE102004015272A1 (en) * 2004-03-29 2005-11-03 Infineon Technologies Ag Biosensor to determine the presence of DNA comprises trap molecules that hybridize with the target molecules over photo diode detector
DE102004021904B4 (en) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Method and device for generating an analysis arrangement with discrete, separate measurement ranges for biological, biochemical or chemical analysis
US7751048B2 (en) * 2004-06-04 2010-07-06 California Institute Of Technology Optofluidic microscope device
US7773227B2 (en) * 2004-06-04 2010-08-10 California Institute Of Technology Optofluidic microscope device featuring a body comprising a fluid channel and having light transmissive regions
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7291824B2 (en) * 2005-12-22 2007-11-06 Palo Alto Research Center Incorporated Photosensing throughout energy range and in subranges
US7522786B2 (en) * 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
WO2006029234A1 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
DE102004056735A1 (en) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Device for performing and analyzing microarray experiments
DE102004056787A1 (en) * 2004-11-24 2006-06-01 Heinrich-Heine-Universität Düsseldorf Apparatus and method for measuring fluorescence in multiple reaction spaces
TWI295730B (en) * 2004-11-25 2008-04-11 Ind Tech Res Inst Microfluidic chip for sample assay and method thereof
US7560417B2 (en) 2005-01-13 2009-07-14 Wisconsin Alumni Research Foundation Method and apparatus for parallel synthesis of chain molecules such as DNA
AU2006236410B2 (en) * 2005-04-19 2012-11-01 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
DE102005018337A1 (en) * 2005-04-20 2006-11-02 Micronas Gmbh Micro-optical detection system and method for determining temperature-dependent parameters of analytes
GB0509833D0 (en) * 2005-05-16 2005-06-22 Isis Innovation Cell analysis
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
JP4607684B2 (en) * 2005-06-29 2011-01-05 富士フイルム株式会社 Flow path block, sensor unit, and measuring device using total reflection attenuation
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7760274B2 (en) 2005-12-08 2010-07-20 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array, apparatus for fabricating biomolecule array or polymer array including the programmable mask, and method of fabricating biomolecule array or polymer array using the programmable mask
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US7547904B2 (en) * 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7768654B2 (en) 2006-05-02 2010-08-03 California Institute Of Technology On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference
US9041938B2 (en) 2006-05-02 2015-05-26 California Institute Of Technology Surface wave assisted structures and systems
JP4431549B2 (en) * 2006-05-31 2010-03-17 株式会社日立ハイテクノロジーズ Fluorescence analyzer
US20120269728A1 (en) * 2006-08-02 2012-10-25 Antara Biosciences Inc. Methods and compositions for detecting one or more target agents using tracking components
DE102006039479A1 (en) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmable oligonucleotide synthesis
WO2008049795A1 (en) * 2006-10-23 2008-05-02 Flexgen Bv Method and system for calibrating laser focus and position in micro-arrays
US7532128B2 (en) * 2006-10-25 2009-05-12 Alverix, Inc. Position sensitive indicator detection
DE102006056949B4 (en) * 2006-11-30 2011-12-22 Ruprecht-Karls-Universität Heidelberg Method and device for detecting at least one property of at least one object with a microchip
DE102007018833A1 (en) 2007-04-20 2008-10-23 Febit Holding Gmbh Molecular-biological processing unit for detection, analysis of genomes, for producing e.g. synthetic nucleic acids, comprises device for in-situ-synthesis of arrays of receptors
DE102006062089A1 (en) 2006-12-29 2008-07-03 Febit Holding Gmbh Molecular biology process system comprises a device for synthesis of receptor arrays, devices for performing fluidic steps, a detection unit and programmable control units
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US7852490B2 (en) * 2007-02-05 2010-12-14 Palo Alto Research Center Incorporated Implanting optical cavity structures
US7936463B2 (en) * 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
US7633629B2 (en) * 2007-02-05 2009-12-15 Palo Alto Research Center Incorporated Tuning optical cavities
US7529438B2 (en) * 2007-07-13 2009-05-05 Palo Alto Research Center Incorporated Producing fluidic waveguides
US7522811B2 (en) * 2007-07-13 2009-04-21 Palo Alto Research Center Incorporated Producing sandwich waveguides
ES2488090T3 (en) * 2007-07-27 2014-08-26 F. Hoffmann-La Roche Ag Orientation identification label, reagent container carrier structure and analyzer device
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
DE102007054602A1 (en) * 2007-11-15 2009-05-28 Deutsches Zentrum für Luft- und Raumfahrt e.V. Condition parameter's distribution detecting method for use in e.g. medical diagnosis, involves registering signals with different wavelengths from probes by using camera, and separately detecting signals based on output signals of camera
DE202007019582U1 (en) 2007-11-15 2014-01-30 Deutsches Zentrum für Luft- und Raumfahrt e.V. Measurement setup for detecting the distribution of at least one state variable in a measuring field with different probes
DE102007056398A1 (en) 2007-11-23 2009-05-28 Febit Holding Gmbh Flexible extraction method for the preparation of sequence-specific molecule libraries
US8320983B2 (en) * 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US8373860B2 (en) 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
WO2009111573A2 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Optofluidic microscope device with photosensor array
WO2009111577A1 (en) * 2008-03-04 2009-09-11 California Institute Of Technology Methods of using optofluidic microscope devices
US8325349B2 (en) * 2008-03-04 2012-12-04 California Institute Of Technology Focal plane adjustment by back propagation in optofluidic microscope devices
DE102008021365A1 (en) * 2008-04-29 2009-01-22 Siemens Aktiengesellschaft Method for inserting reagents in microchannels of analyzer, involves providing dispensation unit by which reagents are dispensed, and analyzer, which has microchannels
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
CN107329280A (en) 2008-09-25 2017-11-07 纽约市哥伦比亚大学托管会 Device, the apparatus and method of light stimulus and structure imaging are provided
RU2385940C1 (en) * 2008-10-23 2010-04-10 Общество с ограниченной ответственностью "ВИНТЕЛ" Method for real-time detection of nucleic acids by polymerase chain reaction and device for implementation thereof
EP2380055A4 (en) * 2009-01-21 2012-07-11 California Inst Of Techn Quantitative differential interference contrast (dic) devices for computed depth sectioning
WO2010094772A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
WO2010106109A1 (en) 2009-03-17 2010-09-23 Febit Holding Gmbh Multi-use of biochips
DE102009014080B4 (en) * 2009-03-23 2011-12-15 Baumer Innotec Ag Device for determining particle sizes
FR2943789B1 (en) * 2009-03-26 2013-07-26 Commissariat Energie Atomique METHOD AND DEVICE FOR CHARACTERIZING THE DYNAMIC OF COAGULATION OR SEDIMENTATION OF A FLUID SUCH AS BLOOD OR BLOOD PLASMA
KR20100109196A (en) * 2009-03-31 2010-10-08 삼성전자주식회사 A system and method of measuring object's concentration using for transmission or reflection of light
US8300971B2 (en) * 2009-04-17 2012-10-30 LevelSet Systems, Inc. Method and apparatus for image processing for massive parallel DNA sequencing
US8416400B2 (en) * 2009-06-03 2013-04-09 California Institute Of Technology Wavefront imaging sensor
WO2011035299A2 (en) * 2009-09-21 2011-03-24 California Institute Of Technology Reflective focusing and transmissive projection device
CN101698146B (en) * 2009-09-24 2011-10-26 复旦大学附属肿瘤医院 Microscale reactor for synthesizing radioactive drug and application thereof
JP5012873B2 (en) * 2009-10-14 2012-08-29 カシオ計算機株式会社 Image processing device
CN105974571B (en) 2009-10-28 2019-05-28 阿兰蒂克微科学股份有限公司 Micro-imaging
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
WO2011054614A1 (en) * 2009-11-05 2011-05-12 Waterford Institute Of Technology A nanohole array biosensor
EP2542890B1 (en) 2010-03-01 2015-05-06 Quanterix Corporation Methods for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CN102792151B (en) * 2010-03-23 2015-11-25 加州理工学院 For the super resolution optofluidic microscope of 2D and 3D imaging
DE102010018678B4 (en) 2010-04-28 2017-06-29 Sartorius Stedim Biotech Gmbh Bioreactor arrangement, shaker and method for irradiating a medium in a bioreactor
SE535918C2 (en) * 2010-06-10 2013-02-19 Hemocue Ab Detection of magnetically labeled biological components
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
WO2012030995A2 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Optical system for high resolution thermal melt detection
US8536545B2 (en) 2010-09-09 2013-09-17 California Institute Of Technology Delayed emission detection devices and methods
US9643184B2 (en) 2010-10-26 2017-05-09 California Institute Of Technology e-Petri dishes, devices, and systems having a light detector for sampling a sequence of sub-pixel shifted projection images
US9426429B2 (en) 2010-10-26 2016-08-23 California Institute Of Technology Scanning projective lensless microscope system
US9569664B2 (en) 2010-10-26 2017-02-14 California Institute Of Technology Methods for rapid distinction between debris and growing cells
DE102010056289A1 (en) 2010-12-24 2012-06-28 Geneart Ag Process for the preparation of reading frame correct fragment libraries
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
CN103534627A (en) 2011-03-03 2014-01-22 加州理工学院 Light guided pixel
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US9117149B2 (en) 2011-10-07 2015-08-25 Industrial Technology Research Institute Optical registration carrier
PL3327110T3 (en) 2011-11-07 2020-07-27 Rapid Micro Biosystems, Inc. Cassette for sterility testing
KR20130073354A (en) * 2011-12-23 2013-07-03 한국전자통신연구원 Biochip analysis device
CN107841461A (en) 2012-04-16 2018-03-27 快速微型生物系统公司 Cell culture apparatus
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
WO2014168734A1 (en) * 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
DE102013106432A1 (en) * 2013-06-20 2014-12-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Optical indicator unit and device and method for determining a physico-chemical property of a process medium in a process plant
CN110058005A (en) 2013-06-26 2019-07-26 阿兰蒂克微科学股份有限公司 It is improved for micro- sample treatment
ES2943498T3 (en) 2013-08-05 2023-06-13 Twist Bioscience Corp de novo synthesized libraries
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
DE102015003019A1 (en) * 2015-03-06 2016-09-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for the optical detection of movement in a biological sample with spatial extent
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3104208B1 (en) * 2015-06-09 2022-08-24 Nokia Technologies Oy Electronic circuitry for a valve for the transfer of an optically-active fluid from a first to a second reservoir
WO2017010375A1 (en) * 2015-07-10 2017-01-19 ヤマト科学株式会社 Tissue sample analysis device and tissue sample analysis system
JP6239562B2 (en) * 2015-09-14 2017-11-29 株式会社東芝 LIGHTING DEVICE AND BIO INFORMATION MEASURING DEVICE INCLUDING THE SAME
GB2557529A (en) 2015-09-18 2018-06-20 Twist Bioscience Corp Oligonucleic acid variant libraries and synthesis thereof
WO2017053450A1 (en) 2015-09-22 2017-03-30 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
WO2017095958A1 (en) 2015-12-01 2017-06-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
CN106248764B (en) * 2016-08-03 2020-03-24 南京山诺生物科技有限公司 Real-time visual sharing and integrated imaging nucleic acid electrophoresis device and operation method thereof
CN109996876A (en) 2016-08-22 2019-07-09 特韦斯特生物科学公司 The nucleic acid library of de novo formation
WO2018057526A2 (en) 2016-09-21 2018-03-29 Twist Bioscience Corporation Nucleic acid based data storage
KR20180046098A (en) * 2016-10-27 2018-05-08 삼성전자주식회사 Test Apparatus, Test System and Control Method of Test Apparatus
AU2017378492B2 (en) 2016-12-16 2022-06-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US11550939B2 (en) 2017-02-22 2023-01-10 Twist Bioscience Corporation Nucleic acid based data storage using enzymatic bioencryption
CA3056388A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018231872A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
SG11202002194UA (en) 2017-09-11 2020-04-29 Twist Bioscience Corp Gpcr binding proteins and synthesis thereof
KR20240024357A (en) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 Heated nanowells for polynucleotide synthesis
DE102017127671A1 (en) * 2017-11-23 2019-05-23 Osram Opto Semiconductors Gmbh Photonic gas sensor and method of making a photonic gas sensor
KR20200106067A (en) 2018-01-04 2020-09-10 트위스트 바이오사이언스 코포레이션 DNA-based digital information storage
EP3814497A4 (en) 2018-05-18 2022-03-02 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11684903B2 (en) 2018-10-24 2023-06-27 Daniel Shafer Microscale chemical reactors
CN109289725A (en) * 2018-11-14 2019-02-01 山东金德新材料有限公司 A kind of novel micro passage reaction
WO2020127828A1 (en) * 2018-12-21 2020-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device, measurement system and method for capturing an at least partly reflective surface using two reflection patterns
CN113785057A (en) 2019-02-26 2021-12-10 特韦斯特生物科学公司 Variant nucleic acid libraries for antibody optimization
CA3131689A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
AU2020298294A1 (en) 2019-06-21 2022-02-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors
DE102020123949A1 (en) 2020-09-15 2022-03-17 IMMS Institut für Mikroelektronik- und Mechatronik-Systeme gemeinnützige GmbH (IMMS GmbH) Electrochemical sensor arrangement and use of a photoelectric sensor for determining charge carriers in a medium
WO2023187429A1 (en) * 2022-03-31 2023-10-05 Thalesnano Zrt Flow-through type apparatus for performing chemical reaction of reagents principally in space

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643738A (en) * 1994-11-10 1997-07-01 David Sarnoff Research Center, Inc. Method of synthesis of plurality of compounds in parallel using a partitioned solid support
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1107714A (en) * 1964-04-18 1968-03-27 Dowty Technical Dev Ltd Hydraulic power transmission
US4342832A (en) 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3301833A1 (en) 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL OLIGONOCLEOTIDES IN A SOLID PHASE
DE8309254U1 (en) 1983-03-29 1985-01-03 Straub, Hans, Dipl.-Ing.(FH), 7345 Deggingen DISTRIBUTION UNIT FOR THE PIPES OF CENTRAL HEATING SYSTEMS
DE3322373C2 (en) * 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Test means and methods for the detection of antigens and / or antibodies
SE8303626D0 (en) 1983-06-23 1983-06-23 Kabigen Ab A RECOMBINANT PLASMID AND A TRANSFORMANT MICROORGANISM, A POLYDOXYREBONUCLEOTIDE SEGMENT, A PROCESS FOR PRODUCING A BIOLOGICALLY ACTIVE PROTEIN, AND THE PROTEIN THUS PRODUCED
ATE143289T1 (en) * 1984-06-13 1996-10-15 Applied Research Systems APPARATUS USED IN CHEMICAL TESTING PROCEDURES
EP0316018A3 (en) 1985-03-29 1989-07-26 Cetus Oncology Corporation Modification of dna sequences
SE458968B (en) * 1987-06-16 1989-05-22 Wallac Oy BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES
GB8714270D0 (en) * 1987-06-18 1987-07-22 Williams G R Analysis of carbohydrates
US5162863A (en) * 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
JPH03505966A (en) 1988-07-14 1991-12-26 ベイラー カレッジ オブ メディシン Solid-phase assembly and reassembly method for biopolymers
ATE143696T1 (en) 1989-02-28 1996-10-15 Canon Kk PARTIALLY DOUBLE STRANDED OLIGONUCLEOTIDE AND METHOD FOR FORMING IT
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6309822B1 (en) * 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
FR2652423B1 (en) 1989-09-22 1992-05-22 Ardt Rgle Dev Techn MICROLITHOGRAPHY PROCESS FOR THE PRODUCTION OF SUBMICROMETRIC SURFACE STRUCTURES ON A SUBSTRATE OF THE TYPE OF A SILICON WAFER, AS WELL AS A DEVICE USING THE SAME.
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
WO1991018276A1 (en) 1990-05-22 1991-11-28 Kelly Kenneth A Microassay strip device for immunoassay
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
EP0562025B1 (en) 1990-12-06 2001-02-07 Affymetrix, Inc. (a Delaware Corporation) Compounds and their use in a binary synthesis strategy
EP0493137B1 (en) 1990-12-28 1998-09-23 Research Development Corporation of Japan A method for forming ultra-fine structures
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
AU669489B2 (en) 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5239176A (en) * 1991-10-03 1993-08-24 Foster-Miller, Inc. Tapered optical fiber sensing attenuated total reflectance
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5247180A (en) 1991-12-30 1993-09-21 Texas Instruments Incorporated Stereolithographic apparatus and method of use
US5258295A (en) * 1992-02-25 1993-11-02 Glyko, Inc. Fluorophore-assisted cloning analysis
GB9206671D0 (en) 1992-03-27 1992-05-13 Cranfield Biotech Ltd Electrochemical detection of dna hybridisation
DK0660936T3 (en) * 1992-09-14 1999-05-25 Stanford Res Inst Int Up-converting reporter molecule for biological and other assays using laser excitation technique
WO1994012632A1 (en) 1992-11-27 1994-06-09 University College London Improvements in nucleic acid synthesis by pcr
DE4241871A1 (en) 1992-12-11 1994-06-16 Schulz Rudolf Ing Grad Coupled circuit elements for optical molecular computer with associative memories - are combined into bio-chip by enzyme reactions yielding microscopic metallic particles for conduction of program and data signals
US5368823A (en) 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
EP0706646B1 (en) 1993-07-02 1998-03-25 Institut Für Molekulare Biologie E.V. Sample holder and its use
DE4325724A1 (en) 1993-07-30 1995-02-02 Paul Dr Debbage Device and method for examining an object and for affecting the object
AU671688B2 (en) 1993-09-28 1996-09-05 Beckman Instruments, Inc. Biopolymer synthesis utilizing surface activated, organic polymers
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
DE4343591A1 (en) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Process for the evolutionary design and synthesis of functional polymers based on shape elements and shape codes
DE69422604T2 (en) 1994-03-08 2000-06-08 Zeptosens Ag Witterwil Apparatus and method that combine bioaffinity assay and electrophoretic separation
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US6974666B1 (en) * 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
JPH08136546A (en) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk Method for analyzing substance
US5891738A (en) * 1995-01-16 1999-04-06 Erkki Soini Biospecific multiparameter assay method
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US6066448A (en) 1995-03-10 2000-05-23 Meso Sclae Technologies, Llc. Multi-array, multi-specific electrochemiluminescence testing
US5736257A (en) * 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5582705A (en) * 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
WO1997006468A2 (en) 1995-07-28 1997-02-20 Ely Michael Rabani Pattern formation, replication, fabrication and devices thereby
US5807525A (en) 1995-08-17 1998-09-15 Hybridon, Inc. Apparatus and process for multi stage solid phase synthesis of long chained organic molecules
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5728251A (en) 1995-09-27 1998-03-17 Research Frontiers Inc Light modulating film of improved UV stability for a light valve
US5667195A (en) * 1995-11-13 1997-09-16 Matthew Howard McCormick Fluid drain apparatus
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
JP3233851B2 (en) 1996-04-24 2001-12-04 繁織 竹中 Electrochemical detection method of gene and its device
JP2000510233A (en) 1996-04-25 2000-08-08 ペンス,インコーポレイテッド Biosensor device and method
US5851804A (en) 1996-05-06 1998-12-22 Apollon, Inc. Chimeric kanamycin resistance gene
WO1998003683A1 (en) 1996-07-19 1998-01-29 The Regents Of The University Of Michigan Dna encoding canine von willebrand factor and methods of use
US5871628A (en) 1996-08-22 1999-02-16 The University Of Texas System Automatic sequencer/genotyper having extended spectral response
GB9621122D0 (en) * 1996-10-10 1996-11-27 Cambridge Imaging Ltd Improvements in and relating to methods and apparatus for assay analysis
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
IES80556B2 (en) 1997-01-10 1998-09-23 Robert Arpad Foster Electrochemical diagnostic detection device
US5812272A (en) 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
CA2291180A1 (en) * 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
DE69838067T2 (en) 1997-05-23 2008-03-13 Bioarray Solutions Ltd. COLOR CODING AND SITU INQUIRY OF MATRIX-COUPLED CHEMICAL COMPOUNDS
DE19726634A1 (en) 1997-06-18 1998-12-24 Biotools Inst Fuer Computerint Method and device for immobilizing macromolecules
AU745989B2 (en) 1997-08-13 2002-04-11 Cepheid Microstructures for the manipulation of fluid samples
JP3938982B2 (en) * 1997-08-29 2007-06-27 オリンパス株式会社 DNA capillary
AU9393398A (en) 1997-09-16 1999-04-05 Egea Biosciences, Inc. Method for the complete chemical synthesis and assembly of genes and genomes
EP1021558A1 (en) 1997-10-10 2000-07-26 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6177558B1 (en) 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US20020076735A1 (en) * 1998-09-25 2002-06-20 Williams Lewis T. Diagnostic and therapeutic methods using molecules differentially expressed in cancer cells
JP2002500897A (en) 1998-01-27 2002-01-15 クリニカル・マイクロ・センサーズ・インコーポレイテッド Amplification of electronic nucleic acid detection
AU2586799A (en) 1998-02-06 1999-08-23 Affymetrix, Inc. Method of quality control in manufacturing processes
US6426184B1 (en) * 1998-02-11 2002-07-30 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
JP4698023B2 (en) 1998-02-23 2011-06-08 ウイスコンシン アラムニ リサーチ ファンデーション Method and apparatus for synthesizing DNA probe array
US6130046A (en) 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
DE19823454A1 (en) * 1998-05-18 1999-11-25 Epigenomics Gmbh Photolithographic production of oligonucleotide array for manufacture of DNA chips
WO1999060170A1 (en) 1998-05-21 1999-11-25 Hyseq, Inc. Linear arrays of immobilized compounds and methods of using same
DE19823876B4 (en) 1998-05-28 2004-07-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Component loaded with different connections (biochip) and method for its production
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
WO1999063385A1 (en) * 1998-06-04 1999-12-09 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
RU2161653C2 (en) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Method of quantitative electrochemical analysis of biological molecules
US7097974B1 (en) 1998-08-28 2006-08-29 Febit Biotech Gmbh Support for a method for determining an analyte and a method for producing the support
DE19842164B4 (en) 1998-09-15 2004-06-03 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Quality control procedures for the construction of oligomer grids
DE19921940C2 (en) 1998-11-23 2003-02-06 Friz Biochem Gmbh Method for the electrochemical detection of nucleic acid oligomer hybrids
DE19964220C2 (en) 1998-11-23 2003-07-03 Friz Biochem Gmbh Modified nucleic acid oligomer, useful for sequencing by hybridization, is substituted by redox agent to allow electrical detection of hybridization
DE19901761A1 (en) 1999-01-18 1999-07-01 Gerhard Dr Hartwich Oligonucleotides tagged with photoinducible redox-active unit
WO2000042217A2 (en) 1999-01-18 2000-07-20 Fritz, Biochem Gmbh Method for electrochemically detecting nucleic acid-oligomer hybridisation events
EP1728860B1 (en) 1999-02-19 2010-01-27 febit holding GmbH Method for producing polymers
DE19910392B4 (en) 1999-03-05 2005-03-17 Clondiag Chip Technologies Gmbh Micro column reactor
WO2000053617A1 (en) 1999-03-08 2000-09-14 Protogene Laboratories, Inc. Methods and compositions for economically synthesizing and assembling long dna sequences
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
DE10051396A1 (en) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
ATE303863T1 (en) 2000-10-17 2005-09-15 Febit Ag METHOD AND DEVICE FOR INTEGRATED SYNTHESIS AND ANALYTE DETERMINATION ON A SUPPORT
US20020160427A1 (en) 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5643738A (en) * 1994-11-10 1997-07-01 David Sarnoff Research Center, Inc. Method of synthesis of plurality of compounds in parallel using a partitioned solid support
WO1998013683A1 (en) * 1996-09-26 1998-04-02 Sarnoff Corporation Massively parallel detection

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ATE481637T1 (en) 2010-10-15
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WO2000012123A2 (en) 2000-03-09
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EP1117478A2 (en) 2001-07-25
EP1742058B1 (en) 2011-11-30
US7737088B1 (en) 2010-06-15
ATE535814T1 (en) 2011-12-15
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