EP1780290A3 - Apparatus for amplifying nucleic acids - Google Patents
Apparatus for amplifying nucleic acids Download PDFInfo
- Publication number
- EP1780290A3 EP1780290A3 EP06022542A EP06022542A EP1780290A3 EP 1780290 A3 EP1780290 A3 EP 1780290A3 EP 06022542 A EP06022542 A EP 06022542A EP 06022542 A EP06022542 A EP 06022542A EP 1780290 A3 EP1780290 A3 EP 1780290A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleic acids
- amplifying nucleic
- modules
- duplicating
- amplifying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/147—Employing temperature sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1883—Means for temperature control using thermal insulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
Abstract
Es wird eine Vorrichtung zur Vervielfältigung und Detektion von Targetsubstanzen, insbesondere von Nukleinsäuren, aus einer Probe beschrieben. Die Vorrichtung umfasst mindestens zwei Vervielfältigungsmodule (4) sowie mindestens zwei Detektionsmodule (5), die auf einem Bauteil angeordnet sind, wobei die Vervielfältigungsmodule (4) über eine jeweils individuell anzusteuernde Temperierungseinheit (6) temperierbar sind. An apparatus for amplifying and detecting target substances, in particular nucleic acids, from a sample is described. The device comprises at least two duplicating modules (4) and at least two detection modules (5) which are arranged on a component, wherein the duplicating modules (4) can be tempered via a temperature control unit (6) to be controlled individually.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200510051850 DE102005051850A1 (en) | 2005-10-28 | 2005-10-28 | Device for duplication and detection of nucleic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1780290A2 EP1780290A2 (en) | 2007-05-02 |
EP1780290A3 true EP1780290A3 (en) | 2008-06-11 |
Family
ID=37667468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06022542A Withdrawn EP1780290A3 (en) | 2005-10-28 | 2006-10-27 | Apparatus for amplifying nucleic acids |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1780290A3 (en) |
DE (1) | DE102005051850A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
DE102006002258B4 (en) * | 2006-01-17 | 2008-08-21 | Siemens Ag | Module for the preparation of a biological sample, biochip set and use of the module |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) * | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
US20080199861A1 (en) * | 2007-02-15 | 2008-08-21 | Honeywell International, Inc. | Real-time microarray apparatus and methods related thereto |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
DE102008025992B4 (en) | 2008-05-30 | 2011-01-27 | Siemens Healthcare Diagnostics Gmbh | Titer plate and method for detecting an analyte |
EP2375238A1 (en) * | 2010-04-01 | 2011-10-12 | Hach Lange GmbH | Fluid analysis device |
CN106190806B (en) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | Scan real-time microfluid thermal cycler and the method for synchronous thermal cycle and scanning optical detection |
KR102121853B1 (en) | 2011-09-30 | 2020-06-12 | 벡톤 디킨슨 앤드 컴퍼니 | Unitized reagent strip |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
CN104040238B (en) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | Polynucleotides sample preparation apparatus |
CN107881219B (en) | 2012-02-03 | 2021-09-10 | 贝克顿·迪金森公司 | External file for molecular diagnostic test assignment and compatibility determination between tests |
CN110004141A (en) * | 2017-12-26 | 2019-07-12 | 台达电子工业股份有限公司 | Nucleic acid extraction method and its extraction cassette |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5755942A (en) * | 1994-11-10 | 1998-05-26 | David Sarnoff Research Center, Inc. | Partitioned microelectronic device array |
US20020110492A1 (en) * | 2001-02-14 | 2002-08-15 | Kalyan Handique | Heat-reduction methods and systems related to microfluidic devices |
US20040043479A1 (en) * | 2000-12-11 | 2004-03-04 | Briscoe Cynthia G. | Multilayerd microfluidic devices for analyte reactions |
WO2004059299A1 (en) * | 2002-12-16 | 2004-07-15 | Cytodiscovery, Inc. | Microfluidic system with integrated permeable membrane |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0927265A4 (en) * | 1996-06-17 | 2000-07-12 | Trustees Of Board Of | Thermocycling apparatus and method |
US7188001B2 (en) * | 1998-03-23 | 2007-03-06 | Cepheid | System and method for temperature control |
US6699713B2 (en) * | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
US7799557B2 (en) * | 2003-12-10 | 2010-09-21 | Samsung Electronics Co., Ltd. | Polymerase chain reaction (PCR) module and multiple PCR system using the same |
-
2005
- 2005-10-28 DE DE200510051850 patent/DE102005051850A1/en not_active Withdrawn
-
2006
- 2006-10-27 EP EP06022542A patent/EP1780290A3/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5755942A (en) * | 1994-11-10 | 1998-05-26 | David Sarnoff Research Center, Inc. | Partitioned microelectronic device array |
US20040043479A1 (en) * | 2000-12-11 | 2004-03-04 | Briscoe Cynthia G. | Multilayerd microfluidic devices for analyte reactions |
US20020110492A1 (en) * | 2001-02-14 | 2002-08-15 | Kalyan Handique | Heat-reduction methods and systems related to microfluidic devices |
WO2004059299A1 (en) * | 2002-12-16 | 2004-07-15 | Cytodiscovery, Inc. | Microfluidic system with integrated permeable membrane |
Non-Patent Citations (2)
Title |
---|
DANIEL J H ET AL: "Silicon microchambers for DNA amplification", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 71, no. 1-2, 1 November 1998 (1998-11-01), pages 81 - 88, XP004140078, ISSN: 0924-4247 * |
KRISHNAN M ET AL: "A novel strategy for the design of multiple reaction systems for genetic analysis", SENSORS AND ACTUATORS A, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 95, no. 2-3, 1 January 2002 (2002-01-01), pages 250 - 258, XP004377899, ISSN: 0924-4247 * |
Also Published As
Publication number | Publication date |
---|---|
EP1780290A2 (en) | 2007-05-02 |
DE102005051850A1 (en) | 2007-05-03 |
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Legal Events
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Effective date: 20081211 |
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AKX | Designation fees paid |
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17Q | First examination report despatched |
Effective date: 20090123 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20090804 |