EP2064644A4 - Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents - Google Patents

Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents

Info

Publication number
EP2064644A4
EP2064644A4 EP07838594A EP07838594A EP2064644A4 EP 2064644 A4 EP2064644 A4 EP 2064644A4 EP 07838594 A EP07838594 A EP 07838594A EP 07838594 A EP07838594 A EP 07838594A EP 2064644 A4 EP2064644 A4 EP 2064644A4
Authority
EP
European Patent Office
Prior art keywords
impedance
exposure
biologically active
active agents
cellular response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07838594A
Other languages
German (de)
French (fr)
Other versions
EP2064644A2 (en
Inventor
Xiaobo Wang
Yama A Abassi
Wenfu Zhang
Xiao Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acea Biosciences Inc
Original Assignee
Acea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Inc filed Critical Acea Biosciences Inc
Publication of EP2064644A2 publication Critical patent/EP2064644A2/en
Publication of EP2064644A4 publication Critical patent/EP2064644A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
EP07838594A 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents Withdrawn EP2064644A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84606706P 2006-09-20 2006-09-20
PCT/US2007/020418 WO2008036375A2 (en) 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents

Publications (2)

Publication Number Publication Date
EP2064644A2 EP2064644A2 (en) 2009-06-03
EP2064644A4 true EP2064644A4 (en) 2010-12-29

Family

ID=39201101

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07838594A Withdrawn EP2064644A4 (en) 2006-09-20 2007-09-20 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents

Country Status (2)

Country Link
EP (1) EP2064644A4 (en)
WO (1) WO2008036375A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015846A1 (en) * 2010-07-16 2012-01-19 Ye Fang Label-free Cellular Pharmacology For Drug Antitarget Assessment
GB201522323D0 (en) 2015-12-17 2016-02-03 Vrije Universiteit Brussel And Katholieke Universiteit Leuven Systems and methods for conducting electrochemical impedance spectroscopy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
WO2005005979A1 (en) * 2003-07-14 2005-01-20 Mds Inc. , Doing Business As Mds Sciex Label-free method for classification and characterization of cellular events

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US8263375B2 (en) * 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2005077104A2 (en) * 2004-02-09 2005-08-25 Xiao Xu Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6377057B1 (en) * 1999-02-18 2002-04-23 The Board Of Trustees Of The Leland Stanford Junior University Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
WO2005005979A1 (en) * 2003-07-14 2005-01-20 Mds Inc. , Doing Business As Mds Sciex Label-free method for classification and characterization of cellular events

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SLAUGHTER G E ET AL: "Artificial Neural Network for Temporal Impedance Recognition of Neurotoxins", INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS, 2006. IJCNN '06, PISCATAWAY, NJ : IEEE OPERATIONS CENTER, PISCATAWAY, NJ, USA LNKD- DOI:10.1109/IJCNN.2006.1716357, 16 July 2006 (2006-07-16), pages 2001 - 2008, XP010948436, ISBN: 978-0-7803-9490-2 *

Also Published As

Publication number Publication date
WO2008036375A2 (en) 2008-03-27
EP2064644A2 (en) 2009-06-03
WO2008036375A3 (en) 2008-10-16

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Legal Events

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Owner name: ACEA BIOSCIENCES, INC.

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