US20010013342A1 - Inhalation device - Google Patents
Inhalation device Download PDFInfo
- Publication number
- US20010013342A1 US20010013342A1 US09/840,875 US84087501A US2001013342A1 US 20010013342 A1 US20010013342 A1 US 20010013342A1 US 84087501 A US84087501 A US 84087501A US 2001013342 A1 US2001013342 A1 US 2001013342A1
- Authority
- US
- United States
- Prior art keywords
- tubular element
- actuator
- valve stem
- canister
- radial surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicinal Preparation (AREA)
- Nozzles (AREA)
Abstract
An actuator for a pressurized metered dose inhaler, including: a tubular section (38) providing an outlet through which medicament is in use inhaled; and a nozzle block (42) including a tubular element (44) having a free end over which the valve stem (14) of a canister (2) is in use located and a spray orifice (50) in fluid communication with the tubular element (44) for directing a spray into the tubular section (38).
Description
- The present invention relates to an actuator for a pressurised metered dose inhaler and a pressurised metered dose inhaler including the same.
- In using conventional pressurised metered dose inhalers with some hydrofluoroalkane (HFA) formulations being developed by the applicant company it has been found that medicament tends to deposit in the valve stems of the canisters thereof. It will be appreciated that this deposition could lead to the user receiving an unusually high dose of medicament if the deposit were at least in part to break away or, indeed, result in the valve stems becoming blocked, thereby rendering the pressurised metered dose inhalers inoperative. Ideally, one would simply Just wash the canisters to remove the deposit. Unfortunately, however, it is not possible to wash the canisters as the formulations are sensitive to moisture and would as a result of washing be contaminated.
- Accordingly, the present invention provides an actuator for a pressurised metered dose inhaler, including: a tubular section providing an outlet through which medicament is in use inhaled; and a nozzle block including a tubular element having a free end over which the valve stem of a canister is in use located and a spray orifice in fluid communication with the tubular element for directing a spray into the tubular section.
- By providing the nozzle block of the actuator with a tubular element over which the valve stem of a canister is located, medicament will deposit on the inner radial surface of the tubular element and not in the valve stem of the canister. In this way, the user is able to prevent the build up of any appreciable amount of deposit by washing the actuator regularly: the actuator being washable when separated from the canister.
- Preferably, the tubular element is configured such that an outer radial surface thereof is a close fit with an inner radial surface of the valve stem of the canister.
- More preferably, the tubular element is configured such that an outer radial surface thereof is a tight fit with an inner radial surface of the valve stem of the canister.
- Preferably, the tubular element is of circular section.
- Preferably, the nozzle block includes an abutment against which in use bears the distal end of the valve stem of the canister.
- More preferably, the abutment comprises a surface which extends radially outwardly of the tubular element.
- In a preferred embodiment the nozzle block includes a further tubular element co-axial with the first-mentioned tubular element such that the tubular elements define an annular channel in which the valve stem of the canister is in use located.
- Preferably, the further tubular element is configured such that an inner radial surface thereof is a close fit with an outer radial surface of the valve stem of the canister.
- More preferably, the further tubular element is configured such that an inner radial surface thereof is a tight fit with an outer radial surface of the valve stem of the canister.
- Preferably, the further tubular element is of circular section.
- The present invention also extends to a pressurised metered dose inhaler comprising the above-described actuator and a canister including a valve stem extending therefrom.
- A preferred embodiment of the present invention will now be described hereinbelow by way of example only with reference to the accompanying drawings, in which:
- FIG. 1 illustrates a front view of an actuator of a pressurized metered dose inhaler in accordance with a preferred embodiment of the present invention;
- FIG. 2 illustrates a side view of the actuator of FIG. 1;
- FIG. 3 illustrates a vertical sectional view of the actuator of FIG. 1; and
- FIG. 4 illustrates a vertical sectional view the pressurised metered dose inhaler of the preferred embodiment of the present invention.
- The pressurised metered dose inhaler comprises an
actuator 1 and an aerosol canister 2 fitted therein. - The canister2 comprises a body 4 which defines a
storage chamber 6 for holding a suspension or solution of a medicament in a propellant under pressure. The body 4 includes ahead 8 which includes ahousing 10 that defines ametering chamber 12 and avalve stem 14 that is movably disposed in thehousing 10 and extends from thehead 8. Thevalve stem 14 is movable between an extended, closed position (as illustrated) and a depressed, open position (not illustrated), thevalve stem 14 normally being biased by acompression spring 16 disposed in thehousing 10 into the closed position. Thevalve stem 14 includes afirst conduit 18 which includes a first, outlet opening 20 located at the distal end of thevalve stem 14 and a second, inlet opening 22 located in the side wall of thevalve stem 14. Thevalve stem 14 further includes asecond conduit 24 in that part thereof which is always disposed within the body 4. Thesecond conduit 24 includes first and second axially-spacedopenings valve stem 14 and enables communication between thestorage chamber 6 and themetering chamber 12 viabores 30 in thehousing 10. In this regard. it will be noted that the structure of themetering chamber 12 and thevalve stem 14 of the canister 2 is known per se. - The
actuator 1 comprises a first, maintubular section 32, one, the upper, end of which is open and provides anopening 34 into which the canister 2 is in use inserted and the other, lower, end of which is closed by awall member 36. Theactuator 1 further comprises a secondtubular section 38 which extends substantially laterally from the other, that is, the lower, end of the maintubular section 32; the secondtubular section 38 acting as a mouthpiece which is in use gripped in the lips of a user and including anopening 40 at the distal end thereof through which medicament is in use inhaled. Theactuator 1 still further comprises anozzle block 42 which extends upwardly from thewail member 36 into the maintubular section 32. Thenozzle block 42 includes a firsttubular element 44, in this embodiment of circular section, over which thevalve stem 14 of the canister 2 is located. The firsttubular element 44 is configured such that the radial dimension of the outer radial surface thereof is a close fit with the inner radial surface of thefirst conduit 18 in thevalve stem 14. In this way, no appreciable amount of medicament can build up between the outer radial surface of the firsttubular element 44 and the inner radial surface of thefirst conduit 18 in thevalve stem 14. In a preferred embodiment the firsttubular element 44 is configured such that the radial dimension of the outer radial surface thereof is a tight fit with the inner radial surface of thefirst conduit 18 in thevalve stem 14. In this way, material cannot escape between the outer radial surface of the firsttubular element 44 and the inner radial surface of thefirst conduit 18 in thevalve stem 14. The firsttubular element 44 is further configured to be of such a length as to extend within thefirst conduit 18 in thevalve stem 14 to a position adjacent that part of the second opening 22 in thevalve stem 14 which is axially closest to distal end of thevalve stem 14. In this way, the second opening 22 in thevalve stem 14 is always open. The firsttubular element 44 is located on the longitudinal axis of the maintubular section 32. In this way, thevalve stem 14 will always be aligned with the firsttubular element 44 on insertion of the canister 2 into theactuator 1, thereby allowing easy fitting and removal. Thenozzle block 42 further includes a secondtubular element 46, in this embodiment also of circular section, which is co-axial with the firsttubular element 44 and is disposed such that the outer radial surface of the firsttubular element 44 and the inner radial surface of the secondtubular element 46 define anannular channel 48, thebottom surface 49 of which provides an abutment for the distal end of thevalve stem 14. The secondtubular element 46 is configured such that the radial dimension of the inner radial surface thereof is a close fit with the outer radial surface of thevalve stem 14. In this way, lateral movement of thevalve stem 14 is prevented, thereby ensuring that the firsttubular element 44 cannot be damaged by such lateral movement of thevalve stem 14. In a preferred embodiment the secondtubular element 46 is configured such that the radial dimension of the inner radial surface thereof is a tight fit with the outer radial surface of thevalve stem 14. In this way, material cannot escape between the outer radial surface of thevalve stem 14 and the inner radial surface of the secondtubular element 46. Thenozzle block 42 still further includes a laterally-directedspray orifice 50 which is in fluid communication with the firsttubular element 44 and configured to direct a spray into the secondtubular section 38 acting as the mouthpiece. - In use, a user grips the mouthpiece provided by the second
tubular section 38 in the lips. The user then depresses the base of the body 4 of the canister 2 which extends out of theopening 34 in the maintubular section 32 so as to release a dose of medicament from the canister 2 and at the same time inhales so as to inhale the dose of medicament. - In this embodiment the
actuator 1 is formed entirely of a plastics material, typically by moulding. In an alternative embodiment the firsttubular element 44 could be provided by a preformed thin-walled metal tube, such as a stainless steel tube, to which is fitted or moulded a component providing the remainder of theactuator 1. - Finally, it will be understood that the present invention has been described in its preferred embodiment and can be modified in many different ways without departing from the scope of the invention as defined by the appended claims.
Claims (11)
1. An actuator for a pressurised metered dose inhaler, including:
a tubular section (38) providing an outlet through which medicament is in use inhaled; and
a nozzle block (42) including a tubular element (44) having a free end over which the valve stem (14) of a canister (2) is in use located and a spray orifice (50) in fluid communication with the tubular element (44) for directing a spray into the tubular section (38).
2. The actuator of , wherein the tubular element (44) is configured such that an outer radial surface thereof is a close fit with an inner radial surface of the valve stem (14) of the canister (2).
claim 1
3. The actuator of , wherein the tubular element (44) is configured such that an outer radial surface thereof is a tight fit with an inner radial surface of the valve stem (14) of the canister (2).
claim 2
4. The actuator of any of to , wherein the tubular element (44) is of circular section.
claims 1
3
5. The actuator of any of to , wherein the nozzle block (42) includes an abutment against which in use bears the distal end of the valve stem (14) of the canister (2).
claims 1
4
6. The actuator of , wherein the abutment comprises a surface (49) which extends radially outwardly of the tubular element (44).
claim 5
7. The actuator of any of to , wherein the nozzle block (42) includes a further tubular element (46) co-axial with the first-mentioned tubular element (44) such that the tubular elements (44, 46) define an annular channel (48) in which the valve stem (14) of the canister (2) is in use located.
claims 1
6
8. The actuator of , wherein the further tubular element (46) is configured such that an inner radial surface thereof is a close fit with an outer radial surface of the valve stem (14) of the canister (2).
claim 7
9. The actuator of , wherein the further tubular element (46) is configured such that an inner radial surface thereof is a tight fit with an outer radial surface of the valve stem (14) of the canister (2).
claim 8
10. The actuator of any of to , wherein the further tubular element (46) is of circular section.
claims 7
9
11. A pressurised metered dose inhaler comprising the actuator of any of to and a canister (2) including a valve stem (14) extending therefrom.
claims 1
10
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/840,875 US20010013342A1 (en) | 1998-07-03 | 2001-04-25 | Inhalation device |
US10/698,942 US7007689B2 (en) | 1998-07-03 | 2003-11-03 | Inhalation device |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9802398A SE9802398D0 (en) | 1998-07-03 | 1998-07-03 | Inhalation device |
SE9802398-9 | 1999-07-01 | ||
PCT/SE1999/001198 WO2000001436A1 (en) | 1998-07-03 | 1999-07-01 | Inhalation device |
US38029499A | 1999-08-31 | 1999-08-31 | |
US09/840,875 US20010013342A1 (en) | 1998-07-03 | 2001-04-25 | Inhalation device |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1999/001198 Continuation WO2000001436A1 (en) | 1998-07-03 | 1999-07-01 | Inhalation device |
US38029499A Continuation | 1998-07-03 | 1999-08-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/698,942 Continuation US7007689B2 (en) | 1998-07-03 | 2003-11-03 | Inhalation device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20010013342A1 true US20010013342A1 (en) | 2001-08-16 |
Family
ID=20411958
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/840,875 Abandoned US20010013342A1 (en) | 1998-07-03 | 2001-04-25 | Inhalation device |
US10/698,942 Expired - Fee Related US7007689B2 (en) | 1998-07-03 | 2003-11-03 | Inhalation device |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/698,942 Expired - Fee Related US7007689B2 (en) | 1998-07-03 | 2003-11-03 | Inhalation device |
Country Status (6)
Country | Link |
---|---|
US (2) | US20010013342A1 (en) |
EP (1) | EP1094860A1 (en) |
JP (1) | JP4064632B2 (en) |
AU (1) | AU5075299A (en) |
SE (1) | SE9802398D0 (en) |
WO (1) | WO2000001436A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090211578A1 (en) * | 2005-08-01 | 2009-08-27 | Ian Fletcher | Inhaler valve |
US20100012115A1 (en) * | 2005-09-09 | 2010-01-21 | Raymond John Bacon | Dispenser |
US20100147293A1 (en) * | 2001-06-26 | 2010-06-17 | Norton Healthcare, Ltd. | Aerosol actuator |
US8329271B2 (en) | 2004-12-23 | 2012-12-11 | Clinical Designs Limited | Medicament container |
US9114221B2 (en) | 2009-03-10 | 2015-08-25 | Euro-Celtique S.A. | Counter |
US9415178B2 (en) | 2009-03-10 | 2016-08-16 | Euro-Celtique S.A. | Counter |
US9707360B2 (en) | 2004-11-19 | 2017-07-18 | Clinical Designs Limited | Substance source |
EP3578217A1 (en) * | 2018-06-08 | 2019-12-11 | Presspart Manufacturing S.A. | Inhaler |
WO2024058343A1 (en) * | 2022-09-14 | 2024-03-21 | 주식회사 케이티앤지 | Inhaler |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8440791B2 (en) * | 2001-09-06 | 2013-05-14 | Mgp Biotechnologies, Llc | Thimerosal removal device |
US7767872B2 (en) * | 2001-09-06 | 2010-08-03 | Mpg Biotechnologies, Llc | Thimerosal removal device |
US7900625B2 (en) * | 2005-08-26 | 2011-03-08 | North Carolina State University | Inhaler system for targeted maximum drug-aerosol delivery |
WO2011014562A1 (en) | 2009-07-28 | 2011-02-03 | North Carolina State University | Methods and devices for targeted injection of microspheres |
GB201308679D0 (en) | 2013-05-14 | 2013-06-26 | 3M Innovative Properties Co | Actuator for an inhaler |
GB2544478A (en) * | 2015-11-16 | 2017-05-24 | 3M Innovative Properties Co | Improvements in metered dose inhaler devices |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1479283A (en) * | 1973-07-23 | 1977-07-13 | Bespak Industries Ltd | Inhaler for powdered medicament |
GB9026191D0 (en) * | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
AU6130694A (en) * | 1991-03-05 | 1994-08-15 | Miris Medical Corporation | An automatic aerosol medication delivery system and methods |
FR2683726A1 (en) * | 1991-11-15 | 1993-05-21 | Pesenti Yvan | DEVICE FOR SYNCHRONIZING AEROSOL APPARATUS WITH METERED BOTTLE. |
US5899201A (en) * | 1993-05-26 | 1999-05-04 | Minnesota Mining And Manufacturing Company | Aerosol actuator |
AU1752795A (en) * | 1994-03-10 | 1995-09-25 | Franco Del Bon | Inhalator |
US5598836A (en) * | 1995-05-26 | 1997-02-04 | Healthscan Products, Inc. | Metered dose inhalation unit with slide means |
GB2312379B (en) * | 1996-04-25 | 1999-11-17 | Bespak Plc | Improved inhalers |
GB2312848B (en) * | 1996-04-26 | 1999-11-17 | Bespak Plc | Controlled flow inhalers |
SE9701750D0 (en) * | 1997-05-12 | 1997-05-12 | Astra Pharma Prod | Inhalation device and method of manufacture thereof |
US5827258A (en) | 1997-07-25 | 1998-10-27 | The Procter & Gamble Company | Adjustable compound sanitary napkin |
SE9702796D0 (en) * | 1997-07-25 | 1997-07-25 | Pharmacia & Upjohn Ab | A device at a pharmaceutical container or inhaler |
-
1998
- 1998-07-03 SE SE9802398A patent/SE9802398D0/en unknown
-
1999
- 1999-07-01 AU AU50752/99A patent/AU5075299A/en not_active Abandoned
- 1999-07-01 EP EP99935233A patent/EP1094860A1/en not_active Withdrawn
- 1999-07-01 WO PCT/SE1999/001198 patent/WO2000001436A1/en not_active Application Discontinuation
- 1999-07-01 JP JP2000557880A patent/JP4064632B2/en not_active Expired - Fee Related
-
2001
- 2001-04-25 US US09/840,875 patent/US20010013342A1/en not_active Abandoned
-
2003
- 2003-11-03 US US10/698,942 patent/US7007689B2/en not_active Expired - Fee Related
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100147293A1 (en) * | 2001-06-26 | 2010-06-17 | Norton Healthcare, Ltd. | Aerosol actuator |
US9707360B2 (en) | 2004-11-19 | 2017-07-18 | Clinical Designs Limited | Substance source |
US8329271B2 (en) | 2004-12-23 | 2012-12-11 | Clinical Designs Limited | Medicament container |
US8235044B2 (en) * | 2005-08-01 | 2012-08-07 | Astrazeneca Ab | Inhaler valve |
US20090211578A1 (en) * | 2005-08-01 | 2009-08-27 | Ian Fletcher | Inhaler valve |
US20100012115A1 (en) * | 2005-09-09 | 2010-01-21 | Raymond John Bacon | Dispenser |
US10369307B2 (en) | 2005-09-09 | 2019-08-06 | Clinical Designs Limited | Dispenser |
US9592355B2 (en) | 2005-09-09 | 2017-03-14 | Raymond John Bacon | Dispenser |
US9415178B2 (en) | 2009-03-10 | 2016-08-16 | Euro-Celtique S.A. | Counter |
US9987441B2 (en) | 2009-03-10 | 2018-06-05 | Euro-Celtique S.A. | Counter |
US9114221B2 (en) | 2009-03-10 | 2015-08-25 | Euro-Celtique S.A. | Counter |
EP3578217A1 (en) * | 2018-06-08 | 2019-12-11 | Presspart Manufacturing S.A. | Inhaler |
WO2019234236A1 (en) * | 2018-06-08 | 2019-12-12 | Presspart Manufacturing S.A. | Inhaler |
WO2024058343A1 (en) * | 2022-09-14 | 2024-03-21 | 주식회사 케이티앤지 | Inhaler |
Also Published As
Publication number | Publication date |
---|---|
WO2000001436A1 (en) | 2000-01-13 |
JP4064632B2 (en) | 2008-03-19 |
SE9802398D0 (en) | 1998-07-03 |
AU5075299A (en) | 2000-01-24 |
EP1094860A1 (en) | 2001-05-02 |
JP2002519159A (en) | 2002-07-02 |
US7007689B2 (en) | 2006-03-07 |
US20040134489A1 (en) | 2004-07-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7007689B2 (en) | Inhalation device | |
CA2614626A1 (en) | Inhalation device with a mouthpiece cap releasably secured to the mouthpiece | |
EP1289589B1 (en) | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber | |
CN109415143A (en) | Fill system for electrical smoking device | |
US7131440B2 (en) | Inhalation therapy apparatus having a valve for limiting the inspiration flow | |
US5490497A (en) | Inhalation devices with a reduced risk of blockage | |
FI69962B (en) | INHALERINGSANORDNING | |
CA2565088A1 (en) | Methods and apparatus for delivering aerosolized medication | |
KR0142416B1 (en) | Aerosol dispenser | |
US20060000471A1 (en) | Inhalation aid | |
EP1745816A3 (en) | Aerosol medication delivery apparatus and system with a mouthpiece | |
US5682875A (en) | Aerosol device having a spout to prevent spray head blockage | |
AU2001266806A1 (en) | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber | |
US7967011B2 (en) | Inhalation device | |
EP1008360B1 (en) | Inhalation apparatus | |
WO2002043794A1 (en) | Improved metering valve and actuator for metered dose inhaler | |
US20230276862A1 (en) | Oral dispenser for liquids, in particular for liquids containing nicotine or cannabis | |
CA2298448A1 (en) | Breath coordinated inhaler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |