|Número de publicación||US20020065553 A1|
|Tipo de publicación||Solicitud|
|Número de solicitud||US 10/004,954|
|Fecha de publicación||30 May 2002|
|Fecha de presentación||3 Dic 2001|
|Fecha de prioridad||28 Nov 2000|
|También publicado como||CA2430126A1, DE60114044D1, DE60114044T2, EP1341479A2, EP1341479B1, EP1616535A1, US6517888, WO2002043619A2, WO2002043619A3|
|Número de publicación||004954, 10004954, US 2002/0065553 A1, US 2002/065553 A1, US 20020065553 A1, US 20020065553A1, US 2002065553 A1, US 2002065553A1, US-A1-20020065553, US-A1-2002065553, US2002/0065553A1, US2002/065553A1, US20020065553 A1, US20020065553A1, US2002065553 A1, US2002065553A1|
|Cesionario original||Scimed Life System, Inc.|
|Exportar cita||BiBTeX, EndNote, RefMan|
|Citas de patentes (19), Citada por (64), Clasificaciones (41)|
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet|
 This invention relates generally to a method for manufacturing a medical device. More particularly, the invention is directed to a method for manufacturing a medical device having a coated portion by laser ablation.
 Implantable medical devices, such as prosthesis or stents, are used to reduce restenosis after balloon angioplasty or other procedures involving catheters. Usually, the suitable medical device or stent is cylindrical in shape. The walls of the cylindrical structure can be formed of metal or polymer with openings therein, e.g., a mesh. The stent is implanted into a body lumen, such as a blood vessel, where it stays permanently, to keep the vessel open and to improve blood flow to the heart muscle and relieve symptoms. Stents can also be positioned in other parts of the body, such as the kidneys or the brain. The stent procedure is fairly common, and various types of stents have been developed and actually used. However, since the bare metal surface of the stents may trigger restenosis, the stent surface should be altered to make it more biocompatible. Stents coated with polymers have been offered to reduce likelihood of restenosis caused by the metal surface of stents. Further, there are various types of polymer coats for stents which contain drugs which are delivered to an afflicted area of a body lumen. Drugs may be either bonded chemically, physically or absorbed in the polymer matrix. Also, for the purpose of obtaining drug delivery stents, the drugs may be directly coated or immobilized onto the stents, e.g. using a binding molecule between the drug molecule and the stent surface.
 Previously, such coated stents have been manufactured by shaping the body of the stents first by photo-etching, laser ablation, electron beam ablation, or any other means, and then coating the stents with polymer compositions or drug compositions by dip-coating, spray-coating or any other means. However, due to the complex geometry of the stent, applying an even coating on a metal stent is very difficult. Therefore, methods for easily manufacturing a stent with uniform coating(s) are necessary.
 In addition, the polymer coating, when applied by methods in the art, tends to create bridges at small gaps or corners between stent struts. Also, in the conventional methods, wherein a coating process takes place after a shaping process, it is almost impossible to selectively coat the stent. For example, it is impossible to coat one side of a stent without coating the other side or to apply different coatings to the outside and inside of a stent. Therefore, there is a need for methods of making a stent, especially coated stent, wherein the coating(s) does not form bridges at gaps or corners, and wherein selective coating of the stent can be readily achieved.
 These and other objectives are accomplished by the present invention. To achieve the aforementioned objectives, a method has been invented for manufacturing a medical device having a coated portion by laser ablation.
 An embodiment of the present invention is a method for manufacturing a medical device having a coated portion which comprises obtaining a structure having an inner surface and an outer surface. At least a portion of the inner or outer surface is coated with a first coating material. Then, the coated structure is ablated with a laser to form at least one opening therein to form the coated portion.
 In another embodiment of the present invention, the method for manufacturing a medical device having a coated portion comprises obtaining a plate having a first surface and a second surface. At least a portion of the first surface or second surface is coated with a first coating material. The coated plate is then ablated with a laser to form at least one opening in the coated plate. Afterward, the coated and ablated plate is formed by folding or shaping into the medical device.
FIGS. 1A through 1D show the steps of an embodiment of the present invention.
FIG. 1A depicts a cross-sectional view of a tubular structure.
FIG. 1B depicts a cross-sectional view of the tubular structure after a coating is applied on its inner surface.
FIG. 1C depicts a cross-sectional view of the tubular structure after another coating is applied on its outer surface.
FIG. 1D depicts a cross-sectional view of a coated tube-like portion of a medical device formed by ablating the tubular structure with a laser.
FIG. 2A through 2E show steps of another embodiment of the present invention.
FIG. 2A depicts a cross-sectional view of a plate.
FIG. 2B depicts a cross-sectional view of the plate after a coating is applied on its first surface.
FIG. 2C depicts a cross-sectional view of the plate after another coating is applied on its second surface.
FIG. 2D depicts a cross-sectional view of the coated plate after laser ablation.
FIG. 2E depicts a cross-sectional view of a coated tube-like portion of a medical device made by forming the ablated plate into a desired shape.
 In a method of the present invention, a structure or a plate is coated first, and then, ablated by a laser to form openings. Such ablation may be conducted with a ultrashort-pulse laser. “Ultrashort-pulse lasers” refer to lasers (light amplification by stimulated emission of radiation) consisting of pulses with durations shorter than about 10 pico (=10−11) second. The ultrashort-pulse laser is clearly distinguished from conventional continuous wave and long-pulse lasers (nanosecond (10−9 sec) laser) which have significantly longer pulses.
 When a material is ablated by a conventional laser, the material is removed by thermal ablation wherein the material is locally heated to near melting point or boiling point. Thus, ablation using conventional lasers has various problems. For example, the ablation is furthermore accompanied by a heat transfer and a strong thermal shock to surrounding material which might cause serious damage, such as cracking. Also, the material once removed tends to redeposit or re-solidify on the surrounding surface. Thus, a material ablated by a conventional laser must be cleaned to remove the redeposited material surrounding the cut surface. Hence, if a material having an immobilized molecule on its surface is ablated by a conventional laser, because a clearing step is required, the immobilized molecule may be washed away at the cleaning step. Also, since process parameters for a conventional laser ablation, such as boiling point and absorption of the laser light, varies according to materials to be ablated, a layered material consisting of layers made of different materials cannot be ablated by a conventional laser.
 On the other hand, ablation using an ultrashort-pulse laser is free from such problems. The ultrashort-pulse deposits its energy so quickly that it does not interact at all with the plume of vaporized material, which would distort and bend the incoming beam and produce a rough-edged cut. The plasma plume leaves the surface very rapidly, ensuring that it is well beyond the cut edges before the arrival of the next laser pulse. Since the pulse is very short, atoms in a material to be ablated are stationary in space with respect to the pulse duration. As a result, the ultrashort-pulse laser does not react differently between dielectric materials and electric materials. Thus, any material, including glasses, polymers, ceramics, silicon, and metals, can be ablated with very high precision without damage in surrounding area by ultrashort-pulse lasers due to the absence of heat shock waves. In addition, the surface ablated with a ultrashort-pulse laser has an excellent quality which does not need further polishing as required for a surface ablated with a conventional laser because redeposition is less or absent.
 The lasers suitable for use in the method of the present invention are preferably ultrashort-pulse lasers consisting of pulses shorter than about 10−11 second, preferably shorter than about 10−12 second, and most preferably shorter than about 10−13 second which are referred to as femtosecond lasers. The ultrashort-pulse laser used for the
 The intensity (fluence) of the laser radiation that is required to ablate a material is dependent on the material to be ablated. Specifically each material has its own laser-induced optical breakdown (LIOB) threshold which characterizes the fluence required to ablate the material at a particular pulse width. Also the fluence of the ultrashort-pulse laser suitable for the present invention can be chosen according to the thickness of the tube wall, the thickness of the coating and each material. Furthermore, the number of pulses needed to ablate completely through a material can be calculated for a given energy or fluence.
 For example, a hole without any redeposition can be drilled into a 0.7 mm thick stainless steel plate coated with a 0.3 mm-thick poly(ethylene terephthalate) coating on its one surface, using a laser with a pulse duration of 220 femtosecond and a fluence of 0.6 J/cm2 at a wavelength of 780 nm with a repetition rate of 1 kHz commercial femtosecond Ti:sapphire laser and amplifier system (SPECTRA-PHYSICS, SPITFIRE). As another example, a hole without any redeposition can be drilled into a 0.7 mm-thick piece of tantalum with a 0.3 mm-thick poly(ethylene oxide)/poly(butylene terephthalate) copolymer coating using a laser with a pulse duration of 120 femtosecond and a fluence of 0.5 J/cm2 with the same system used above.
 The laser ablation of the present invention can be conducted using any additional techniques for improved accuracy and efficiency of such ultrashort-pulse laser ablation, e.g. diffractive optical elements (DOEs) and/or polarization trepanning. See C. Momma et al., Beam delivery of femtosecond laser radiation by diffractive optical elements, Appl. Phys. A 67, 517-520 (1998); S. Nolte et al., Polarization effects in ultrashort-pulse laser drilling, Appl. Phys. A 68, 563-567 (1999), both are incorporated herein by reference.
 The ultrashort-pulse lasers are known to artisans. For example, they are thoroughly disclosed by M. D. Perry et al. in Ultrashort-Pulse Laser Machining, Section K-ICALEO 1998, pp. 1-20, which is incorporated herein by reference.
 An embodiment of the present invention is illustrated in FIGS. 1A-1D in which a tubular structure made of a suitable medical device material is coated with a coating material or composition. FIG. 1A depicts a cross-sectional view of a tubular structure 10 made of a suitable medical device material. The inner surface of the tubular structure 10 is coated with first coating material or composition 12 (FIG. 1B). Then, the outer surface of the tubular structure 10 is also coated with second coating material or composition 14 (FIG. 1C) which can be the same as the first coating material or composition. The tubular structure 10 having an inner coating 12 and outer coating 14 is ablated by an ultrashort-pulse laser to form openings that made up a geometric pattern in the tubular structure (FIG. 1D). In this manner, a coated tube-like portion of a medical device 16 is formed. Alternatively, only one of the surfaces, e.g. inner or outer, may be coated.
 Another embodiment is illustrated in FIGS. 2A-2E. FIG. 2A depicts a cross-sectional view of a plate 20 made of a suitable medical device material. A first surface of the plate 20 is coated with first coating material or composition 22 (FIG. 2B). Then, the second surface of the plate 20 is also coated with second coating material or composition 24, which can be the same as the first coating material or composition (FIG. 2C). The plate 20 having first coating 22 and second coating 24 is ablated by an ultrashort-pulse laser to form openings that make up a geometric pattern (FIG. 2D). The plate is then folded into a desired shape to form a coated tube-like portion of a medical device 26.
 The term “structure” used in relation to a medical device means any structure which is at least a part of a medical device, such as a tubular structure. Likewise, the term “coated portion” used in relation to a medical device means any portion of a medical device which has (a) coating(s) on its surface(s). An example of such coated portion is a coated tube-like portion. Medical devices that can be fabricated by the method of the present invention includes those that include a tube-like or cylindrical-like portion. The tube-like portion of the medical device need not to be completely cylindrical. For instance, the cross-section of the tube-like portion can be any shape, such as rectangle, a triangle, etc., not just a circle. Such devices include, without limitation, stents and grafts. A bifurcated stent is also included among the medical devices which can be fabricated by the method of the present invention.
 Preferably, the medical device is a stent. Stents suitable for the present invention include vascular stents such as self-expanding stents and balloon expandable stents. Examples of self-expanding stents are illustrated in U.S. Pat. Nos. 4,655,771 and 4,954,126 issued to Wallsten and 5,061,275 issued to Wallsten et al. Examples of appropriate balloon-expandable stents are shown in U.S. Pat. No. 4,733,665 issued to Palmaz, U.S. Pat. No. 4,800,882 issued to Gianturco and U.S. Pat. No. 4,886,062 issued to Wiktor.
 Appropriate materials for making the medical device are not limited for the present invention, and any material including ceramics, polymers and metals can be used for manufacturing the device by the method of the present invention. Preferably, the device is made of a biocompatible material. Examples for such polymers include poly(ethylene terephthalate), polyacetal, poly(lactic acid), poly(ethylene oxide)/poly(butylene terephthalate) copolymer, and polycarbonate. Examples for such metals include titanium, stainless steel, platinum, tantalum or gold/platinum alloy.
 In the present invention, the term “coating” encompasses all ways of coating, such as using plasma, dipping, spraying, etching, covering, plating, co-extruding and all modern chemical ways of attaching bio-molecules to surfaces as well as conventional coating. The surface is coated with a material by a method known to the artisans, such as dipping into a polymer, spraying a coating composition onto the surface, or attaching biomolecules to surfaces. The surface of the structure or plate is optionally subjected to a pre-treatment, such as roughing, oxidizing or adding a primer, and then coated. Adding a primer is preferable as such pre-treatment. In another embodiment, the structure or plate can be covered with a film. Further, in another embodiment, the structure or plate can be made by co-extrusion of the medical device material and the coating material. More than one coating method can be used to make a medical device. Thickness of coatings can range from almost a single layer of molecules to about 0.1 mm. Suitable thickness as of the coating are known in the art and can be selected by artisans.
 Medical devices coating materials suitable for the present invention include any coating material for the stent which are known to the skilled artisan. Suitable coating materials include, without limitation, metals, such as tantalum, stainless steel, nitinol, titanium, and alloys, polymeric materials, such as poly-L-lactic acid, polycarbonate, polyethylene terephtalate, silicones, polyurethanes, thermoplastic elastomers, ethylene vinyl acetate copolymers, polyolefin elastomers, hydrogels and EPDM rubbers. Such coatings include biologically active molecules, such as heparine or insuline molecules, directly attached to oxide molecules on the surface of the structure as explained below.
 Also, the coating can be a drug-releasing coating which immediately or gradually releases a biologically active material. Coating polymer useful for drug coating includes hydrogel polymers which are often used to contain the biologically active material and are disclosed in U.S. Pat. No. 5,304,121, U.S. Pat. No. 5,464,650, PCT publication WO95/03083 and U.S. Pat. No. 5,120,322, which are incorporated by reference. However, a non-hydrogel can be also used. Although polymeric molecules can be combined with biologically active molecules, biologically active materials can be directly immobilized on the surface. As disclosed in U.S. Pat. No. 5,356,433 to Rowland et al., polysaccharides can be immobilized to metallic surfaces by applying an organosilane coating with amine functionality and then applying a polysaccharide using carbodiimide as a coupling gent. U.S. Pat. No. 5,336,518 to Narayanan et al also discloses that a polysaccharide can be immobilized on a surface by applying a coat of heptafluorobutylmethacrylate (HFBMA) by radiofrequency (RF) plasma deposition, creating functional groups on the surface by RF plasma with water vapor, and then applying the polysaccharide using carbodiimide. Moreover, examples of medical devices, in particular, stents coated with polymer/biologically active material coatings are described in U.S. Pat. No. 5,879,697 which is incorporated herein by reference.
 The term “biologically active material” encompasses therapeutic agents, such as drugs, and also genetic materials and biological materials. The genetic materials mean DNA or RNA, including, without limitation, of DNA/RNA encoding a useful protein stated below, intended to be inserted into a human body including viral vectors and non-viral vectors. Viral vectors include adenoviruses, gutted adenoviruses, adeno-associated virus, retroviruses, alpha virus (Semliki Forest, Sindbis, etc.), lentiviruses, herpes simplex virus, ex vivo modified cells (e.g., stem cells, fibroblasts, myoblasts, satellite cells, pericytes, cardiomyocytes, sketetal myocytes, macrophage), replication competent viruses (e.g., ONYX-015), and hybrid vectors. Non-viral vectors include artificial chromosomes and mini-chromosomes, plasmid DNA vectors (e.g., pCOR), cationic polymers (e.g., polyethyleneimine, polyethyleneimine (PEI)) graft copolymers (e.g., polyether-PEI and polyethylene oxide-PEI), neutral polymers PVP, SP1017 (SUPRATEK), lipids or lipoplexes, nanoparticles and microparticles with and without targeting sequences such as the protein transduction domain (PTD). The biological materials include cells, yeasts, bacteria, proteins, peptides, cytokines and hormones. Examples for peptides and proteins include growth factors (FGF, FGF-1, FGF-2, VEGF, Endotherial Mitogenic Growth Factors, and epidermal growth factors, transforming growth factor α and β platelet derived endothelial growth factor, platelet derived growth factor, tumor necrosis factor α, hepatocyte growth factor and insulin like growth factor), transcription factors, proteinkinases, CD inhibitors, thymidine kinase, and bone morphogenic proteins (BMP's), such as BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8. BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, and BMP-16. Currently preferred BMP's are BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7. These dimeric proteins can be provided as homodimers, heterodimers, or combinations thereof, alone or together with other molecules. Cells can be of human origin (autologous or allogeneic) or from an animal source (xenogeneic), genetically engineered, if desired, to deliver proteins of interest at the transplant site. The delivery media can be formulated as needed to maintain cell function and viability. Cells include whole bone marrow, bone marrow derived mono-nuclear cells, progenitor cells (e.g., endothelial progentitor cells) stem cells (e.g., mesenchymal, hematopoietic, neuronal), pluripotent stem cells, fibroblasts, macrophage, and satellite cells.
 Biologically active material also includes non-genetic therapeutic agents, such as:
 anti-thrombogenic agents such as heparin, heparin derivatives, urokinase, and PPack (dextrophenylalanine proline arginine chloromethylketone);
 anti-proliferative agents such as enoxaprin, angiopeptin, or monoclonal antibodies capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid, amlodipine and doxazosin;
 anti-inflammatory agents such as glucocorticoids, betamethasone, dexamethasone, prednisolone, corticosterone, budesonide, estrogen, sulfasalazine, and mesalamine;
 antineoplastic/antiproliferative/anti-miotic agents such as paclitaxel, 5-fluorouracil, cisplatin, vinblastine, vincristine, epothilones, methotrexate, azathioprine, adriamycin and mutamycin; endostatin, angiostatin and thymidine kinase inhibitors, taxol and its analogs or derivatives;
 anesthetic agents such as lidocaine, bupivacaine, and ropivacaine;
 anti-coagulants such as D-Phe-Pro-Arg chloromethyl keton, an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin anticodies, anti-platelet receptor antibodies, aspirin (aspirin is also classified as an analgesic, antipyretic and anti-inflammatory drug), dipyridamole, protamine, hirudin, prostaglandin inhibitors, platelet inhibitors and tick antiplatelet peptides;
 vascular cell growth promotors such as growth factors, Vascular Endothelial Growth Factors (FEGF, all types including VEGF-2), growth factor receptors, transcriptional activators, and translational promotors;
 vascular cell growth inhibitors such as antiproliferative agents, growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, bifunctional molecules consisting of an antibody and a cytotoxin;
 cholesterol-lowering agents; vasodilating agents; and agents which interfere with endogenous vasoactive mechanisms;
 anti-oxidants, such as probucol;
 antibiotic agents, such as penicillin, cefoxitin, oxacillin, tobranycin
 angiogenic substances, such as acidic and basic fibrobrast growth factors, estrogen including estradiol (E2), estriol (E3) and 17-Beta Estradiol; and
 drugs for heart failure, such as digoxin, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors including captopril and enalopril.
 In the devices made by the method of the invention, both surfaces of the tube-like portion can be coated with a same material at the same time.
 Also, one surface of the structure or plate need not be coated, while the other surface has a coating. A medical device having such portion is preferable for a drug-delivery medical device for delivering a biologically active material to a blood vessel surface while minimizing the amount of biologically active material which is delivered into the blood stream. Such a medical device is also preferable when the coating is easily damaged during implantation of the medical device, e.g., because of the unfolding shear-action of the delivery balloon.
 Further in another embodiment, inner and outer surfaces of the portion of the medical device can be coated with different materials. For example, a stent can have a polymer coating having an anti-thrombogenic agent on the inner surface which directly contacts blood flow and a polymer coating having an anti-inflammatory agent on the outer surface which directly contacts blood vessel wall. The inner surface and the outer surface can be coated by the different methods. Also, there can be more than one coating on a surface. Furthermore, an entire surface of the medical device is not necessarily coated.
 In the present invention, the coated structure or plate is ablated by a laser to form openings. The openings along with the remaining parts of the structure or plate make up the geometric pattern structure of the medical device. The structure or plate can be moved while the laser is held stationary to ablate the structure or plate into pattern, or alternatively, the laser can be programmed to move along a predetermined pattern by a method known to artisans. A combination of both, i.e. moving both the laser and the structure or plate, is also possible. In the present invention, even a coated stent having a complex stent pattern can be made with high precision. A medical devices having multiple coating layers and a complicated geometry pattern can also be easily manufactured by the method of the present invention without flaws such as polymer-bridges at gaps or corners. Also, the layer thickness can be easily controlled by the method of the present invention.
 In the case where a plate is coated and ablated, the plate is formed into a portion of the medical device in the way known to artisans. In case the coated portion is a tube-like portion, it is formed by forming the flat plate into a tube-like shape and attaching the opposing edges of the plate together such as by fusing the two opposing sides. A method of fusing appropriate to a stent material can be chosen. Methods of fusing include fusing by heat or using adhesive.
 After the ablation of the present invention, there is no need to polish the ablated medical device to avoid rough cut surface because of the high quality of the cut surface.
 Furthermore, a plurality of medical devices can be manufactured by coating one large structure and, as ablatin it as explained above, cutting the structure into individual coated portions. For example, if the coated portion is a tube-like portion, a long tubular structure is coated first, and then ablated, and then cut into individual tube-like portions of medical devices. Likewise, a large plate can be coated first, cut into a smaller plate, and then formed into an individual coated structure and ablated. Alternatively, a large coated plate can be shaped into a large coated structure, and then it is cut into individual coated structures as ablated. In this way, a plurality of medical devices be made by using one coating step. Also, all of the medical devices will have uniform coating thicknesses.
 If necessary, the thickness of the coating can be easily measured before the ablation step. For example, it is very useful to know an amount of a biologically active material contained in a medical material. This amount can be calculated in the present invention by measuring the thickness of the coating after the coating is placed on the medical device. For example, based on the concentration of biologically active material in the coating composition, the thickness of the coating, the amount of biologically active material placed on the device can be determined.
 The description contained herein is for purposes of illustration and not for purposes of limitation. Changes and modifications may be made to the embodiments of the description and still be within the scope of the invention. Furthermore, obvious changes, modifications or variations will occur to those skilled in the art. Also, all references cited above are incorporated herein, in their entirety, for all purposes related to this disclosure.
|Patente citada||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US4655771 *||11 Abr 1983||7 Abr 1987||Shepherd Patents S.A.||Prosthesis comprising an expansible or contractile tubular body|
|US4733665 *||7 Nov 1985||29 Mar 1988||Expandable Grafts Partnership||Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft|
|US4800882 *||13 Mar 1987||31 Ene 1989||Cook Incorporated||Endovascular stent and delivery system|
|US4886062 *||19 Oct 1987||12 Dic 1989||Medtronic, Inc.||Intravascular radially expandable stent and method of implant|
|US4954126 *||28 Mar 1989||4 Sep 1990||Shepherd Patents S.A.||Prosthesis comprising an expansible or contractile tubular body|
|US5061275 *||29 Dic 1989||29 Oct 1991||Medinvent S.A.||Self-expanding prosthesis|
|US5120322 *||13 Jun 1990||9 Jun 1992||Lathrotec, Inc.||Method and apparatus for treatment of fibrotic lesions|
|US5304121 *||22 Nov 1991||19 Abr 1994||Boston Scientific Corporation||Drug delivery system making use of a hydrogel polymer coating|
|US5336518 *||11 Dic 1992||9 Ago 1994||Cordis Corporation||Treatment of metallic surfaces using radiofrequency plasma deposition and chemical attachment of bioactive agents|
|US5356433 *||3 Nov 1993||18 Oct 1994||Cordis Corporation||Biocompatible metal surfaces|
|US5464650 *||26 Abr 1993||7 Nov 1995||Medtronic, Inc.||Intravascular stent and method|
|US5780807 *||15 Ene 1997||14 Jul 1998||Advanced Cardiovascular Systems, Inc.||Method and apparatus for direct laser cutting of metal stents|
|US5879697 *||30 Abr 1997||9 Mar 1999||Schneider Usa Inc||Drug-releasing coatings for medical devices|
|US6096070 *||16 May 1996||1 Ago 2000||Med Institute Inc.||Coated implantable medical device|
|US6170327 *||15 Jun 1998||9 Ene 2001||Siemens Aktiengesellschaft||Air mass meter|
|US6171327 *||24 Feb 1999||9 Ene 2001||Scimed Life Systems, Inc.||Intravascular filter and method|
|US6379379 *||13 Ago 1999||30 Abr 2002||Scimed Life Systems, Inc.||Stent with smooth ends|
|US6391052 *||29 Oct 1997||21 May 2002||Scimed Life Systems, Inc.||Stent with collagen|
|US6471721 *||30 Dic 1999||29 Oct 2002||Advanced Cardiovascular Systems, Inc.||Vascular stent having increased radiopacity and method for making same|
|Patente citante||Fecha de presentación||Fecha de publicación||Solicitante||Título|
|US7056337||21 Oct 2003||6 Jun 2006||Cook Incorporated||Natural tissue stent|
|US7407684 *||28 Ene 2004||5 Ago 2008||Boston Scientific Scimed, Inc.||Multi-step method of manufacturing a medical device|
|US7658880||29 Jul 2005||9 Feb 2010||Advanced Cardiovascular Systems, Inc.||Polymeric stent polishing method and apparatus|
|US7662326||27 Abr 2007||16 Feb 2010||Advanced Cardiovascular Systems, Inc.||Compositions containing fast-leaching plasticizers for improved performance of medical devices|
|US7699890||28 Ene 2004||20 Abr 2010||Advanced Cardiovascular Systems, Inc.||Medicated porous metal prosthesis and a method of making the same|
|US7708548||10 Abr 2008||4 May 2010||Advanced Cardiovascular Systems, Inc.||Molds for fabricating stents with profiles for gripping a balloon catheter|
|US7731890||15 Jun 2006||8 Jun 2010||Advanced Cardiovascular Systems, Inc.||Methods of fabricating stents with enhanced fracture toughness|
|US7740791||30 Jun 2006||22 Jun 2010||Advanced Cardiovascular Systems, Inc.||Method of fabricating a stent with features by blow molding|
|US7757543||20 Jul 2010||Advanced Cardiovascular Systems, Inc.||Radio frequency identification monitoring of stents|
|US7761968||25 May 2006||27 Jul 2010||Advanced Cardiovascular Systems, Inc.||Method of crimping a polymeric stent|
|US7794495||17 Jul 2006||14 Sep 2010||Advanced Cardiovascular Systems, Inc.||Controlled degradation of stents|
|US7794776||29 Jun 2006||14 Sep 2010||Abbott Cardiovascular Systems Inc.||Modification of polymer stents with radiation|
|US7823263||9 Jul 2007||2 Nov 2010||Abbott Cardiovascular Systems Inc.||Method of removing stent islands from a stent|
|US7829008||30 May 2007||9 Nov 2010||Abbott Cardiovascular Systems Inc.||Fabricating a stent from a blow molded tube|
|US7842737||29 Sep 2006||30 Nov 2010||Abbott Cardiovascular Systems Inc.||Polymer blend-bioceramic composite implantable medical devices|
|US7857008 *||24 Ago 2006||28 Dic 2010||Boston Scientific Scimed, Inc.||Medical device coating configuration and method for improved lubricity and durability|
|US7867547||19 Dic 2005||11 Ene 2011||Advanced Cardiovascular Systems, Inc.||Selectively coating luminal surfaces of stents|
|US7875233||18 Jul 2005||25 Ene 2011||Advanced Cardiovascular Systems, Inc.||Method of fabricating a biaxially oriented implantable medical device|
|US7886419||18 Jul 2006||15 Feb 2011||Advanced Cardiovascular Systems, Inc.||Stent crimping apparatus and method|
|US7901452||27 Jun 2007||8 Mar 2011||Abbott Cardiovascular Systems Inc.||Method to fabricate a stent having selected morphology to reduce restenosis|
|US7923022||13 Sep 2006||12 Abr 2011||Advanced Cardiovascular Systems, Inc.||Degradable polymeric implantable medical devices with continuous phase and discrete phase|
|US7931683||27 Jul 2007||26 Abr 2011||Boston Scientific Scimed, Inc.||Articles having ceramic coated surfaces|
|US7938855||2 Nov 2007||10 May 2011||Boston Scientific Scimed, Inc.||Deformable underlayer for stent|
|US7942926||11 Jul 2007||17 May 2011||Boston Scientific Scimed, Inc.||Endoprosthesis coating|
|US7951185||6 Ene 2006||31 May 2011||Advanced Cardiovascular Systems, Inc.||Delivery of a stent at an elevated temperature|
|US7951194||22 May 2007||31 May 2011||Abbott Cardiovascular Sysetms Inc.||Bioabsorbable stent with radiopaque coating|
|US7951428||31 Ene 2007||31 May 2011||Regents Of The University Of Minnesota||Electrospray coating of objects|
|US7955381||29 Jun 2007||7 Jun 2011||Advanced Cardiovascular Systems, Inc.||Polymer-bioceramic composite implantable medical device with different types of bioceramic particles|
|US7955382||14 Sep 2007||7 Jun 2011||Boston Scientific Scimed, Inc.||Endoprosthesis with adjustable surface features|
|US7959857||14 Jun 2011||Abbott Cardiovascular Systems Inc.||Radiation sterilization of medical devices|
|US8028646||28 Mar 2006||4 Oct 2011||Regents Of The University Of Minnesota||Coating medical devices|
|US8066762 *||14 Oct 2009||29 Nov 2011||Advanced Cardiovascular Systems, Inc.||Assembly for manufacturing an implantable polymeric medical device|
|US8153591||26 Ago 2004||10 Abr 2012||Gel-Del Technologies, Inc.||Protein biomaterials and biocoacervates and methods of making and using thereof|
|US8425587||23 Abr 2013||Abbott Cardiovascular Systems Inc.||Method of treatment with a bioabsorbable stent with time dependent structure and properties and regio-selective degradation|
|US8465537 *||17 Jun 2004||18 Jun 2013||Gel-Del Technologies, Inc.||Encapsulated or coated stent systems|
|US8529939||8 Dic 2004||10 Sep 2013||Gel-Del Technologies, Inc.||Mucoadhesive drug delivery devices and methods of making and using thereof|
|US8728149||23 Sep 2011||20 May 2014||Advanced Cardiovascular Systems, Inc.||Assembly for making a polymeric medical device|
|US8752267||9 Ago 2013||17 Jun 2014||Abbott Cardiovascular Systems Inc.||Method of making stents with radiopaque markers|
|US8752268||9 Ago 2013||17 Jun 2014||Abbott Cardiovascular Systems Inc.||Method of making stents with radiopaque markers|
|US8771343 *||15 Jun 2007||8 Jul 2014||Boston Scientific Scimed, Inc.||Medical devices with selective titanium oxide coatings|
|US8840660 *||5 Ene 2006||23 Sep 2014||Boston Scientific Scimed, Inc.||Bioerodible endoprostheses and methods of making the same|
|US8911814||22 Dic 2010||16 Dic 2014||Boston Scientific Scimed, Inc.||Medical device coating configuration and method for improved lubricity and durability|
|US8920491 *||17 Abr 2009||30 Dic 2014||Boston Scientific Scimed, Inc.||Medical devices having a coating of inorganic material|
|US9038260||8 May 2014||26 May 2015||Abbott Cardiovascular Systems Inc.||Stent with radiopaque markers|
|US9040816||10 Dic 2007||26 May 2015||Nanocopoeia, Inc.||Methods and apparatus for forming photovoltaic cells using electrospray|
|US9050611||15 Feb 2013||9 Jun 2015||Regents Of The University Of Minnesota||High mass throughput particle generation using multiple nozzle spraying|
|US9072820||26 Jun 2006||7 Jul 2015||Advanced Cardiovascular Systems, Inc.||Polymer composite stent with polymer particles|
|US9107937||30 Mar 2012||18 Ago 2015||Gel-Del Technologies, Inc.||Wound treatments with crosslinked protein amorphous biomaterials|
|US9108217||31 Ene 2008||18 Ago 2015||Nanocopoeia, Inc.||Nanoparticle coating of surfaces|
|US20040241315 *||12 Jul 2004||2 Dic 2004||Regents Of The University Of Minnesota||High mass throughput particle generation using multiple nozzle spraying|
|US20050085898 *||21 Oct 2003||21 Abr 2005||Cook Incorporated.||Natural tissue stent|
|US20050163817 *||29 Abr 2003||28 Jul 2005||Masters David B.||Biomatrix structural containment and fixation systems and methods of use thereof|
|US20050163913 *||28 Ene 2004||28 Jul 2005||Spencer Steven M.||Multi-step method of manufacturing a medical device|
|US20050196440 *||8 Dic 2004||8 Sep 2005||Masters David B.||Mucoadhesive drug delivery devices and methods of making and using thereof|
|US20050266039 *||27 May 2004||1 Dic 2005||Jan Weber||Coated medical device and method for making the same|
|US20090264975 *||17 Abr 2009||22 Oct 2009||Boston Scientific Scimed, Inc.||Medical devices having a coating of inorganic material|
|US20110153005 *||23 Jun 2011||Claus Harder||Medical implant, coating method and implantation method|
|EP1626751A2 *||6 May 2004||22 Feb 2006||SciMed Life Systems, Inc.||Processes for producing polymer coatings|
|EP2529761A1 *||31 Ene 2007||5 Dic 2012||Nanocopoeia, Inc.||Nanoparticle coating of surfaces|
|WO2007006043A2 *||5 Jul 2006||11 Ene 2007||Boston Scient Scimed Inc||Medical devices with machined layers for controlled communication with underlying regions|
|WO2007089881A2 *||31 Ene 2007||9 Ago 2007||Univ Minnesota||Electrospray coating of objects|
|WO2007089883A2 *||31 Ene 2007||9 Ago 2007||Nanocopoeia Inc||Nanoparticle coating of surfaces|
|WO2013178297A1||22 Ene 2013||5 Dic 2013||Admedes Schuessler Gmbh||Method for producing a body implant, assembly consisting of a guide wire and a body implant, and a medical instrument|
|WO2013178361A1||29 May 2013||5 Dic 2013||Admedes Schuessler Gmbh||Method for producing a body implant, subassembly made of a guide wire and a body implant, and medical instrument|
|Clasificación de EE.UU.||623/1.46, 604/264, 427/2.28|
|Clasificación internacional||A61F2/84, B23K26/06, A61F2/06, A61F2/04, A61F2/00, B23K26/40, A61F2/90|
|Clasificación cooperativa||B23K26/408, B23K26/381, B23K26/4065, A61L2400/18, A61F2240/001, A61L31/08, B23K26/4075, B23K26/0635, B23K26/407, B23K26/4015, B23K2203/14, B23K26/4085, B23K2203/18, A61F2/91, A61L31/14, B23K26/401, B23K26/4095, B23K26/4005, B23K2203/04|
|Clasificación europea||B23K26/40B11B12, B23K26/40A2, B23K26/40B11, B23K26/40B7H, B23K26/40A, B23K26/40L, B23K26/40A3, A61L31/14, B23K26/38B, A61L31/08, A61F2/91, B23K26/06B4B|