US20020111670A1 - Method and intravascular stent for reducing complications after implantation of an intravascular stent - Google Patents
Method and intravascular stent for reducing complications after implantation of an intravascular stent Download PDFInfo
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- US20020111670A1 US20020111670A1 US10/087,065 US8706502A US2002111670A1 US 20020111670 A1 US20020111670 A1 US 20020111670A1 US 8706502 A US8706502 A US 8706502A US 2002111670 A1 US2002111670 A1 US 2002111670A1
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- 17beta
- estradiol
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- vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
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- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00574—Coating or prosthesis-covering structure made of carbon, e.g. of pyrocarbon
- A61F2310/0058—Coating made of diamond or of diamond-like carbon DLC
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Definitions
- This invention relates to a method of reducing complications after implantation of an intravascular stent and, more particularly, for reducing the risk of restenosis due to stent implantation.
- the invention further relates to a method for producing an intravascular stent reducing complications after implantation into a vessel and, more particularly, reducing the risk of restenosis due to stent implantation.
- the invention further relates to the use of vessel healing substances after implantation of an intravascular stent and, more particularly, to the use of vessel healing substances during manufacture of an intravascular stent.
- the invention finally relates to an arrangement for coating one or more intravascular stents with a coating substance.
- An intravascular stent is a prosthesis which may be placed within a body passageway containing endothelial cells such as any vein, artery or blood vessel within the vascular system.
- the stent is inserted into a vessel and placed at a site of vascular occlusion.
- the stent is expanded at this site in order to contact the vessel wall, thereby widening the vessel and providing mechanical support for the wall.
- Stents are typically manufactured from special tubes of metal or other material compositions (e.g. stainless steel, tantalum, nitinol) or from coil or plait structures of metal and/or plastics.
- the stents may be inserted into the vessel in different ways. Before it is inserted, the stent can e.g.
- the support can be a balloon catheter.
- the crimped stent is then transported by means of the balloon catheter into the vessel to the site of stent placement.
- the stent is fixed in the vessel by being expanded, e.g. by increasing the internal pressure of the balloon catheter by means of a pump, e.g. a hand pump. Thereby, the structure of the stent is deformed and the stent urges against the wall of the vessel. After the balloon catheter has been removed, the stent is dimensionally stable in the vessel.
- a similar process is used for inserting so-called self-expandable stents. These stents do not need any external pressure in order to expand, they expand due to restoring forces or due to the ambient conditions (flow, temperature etc.). Thus, an inserted stent expands and supports the vessel wall and can eliminate stenosis.
- a stent in a vessel can result in complications, e.g. restenosis. Restenosis can e.g. take place at the ends of the stent or in the stent itself (“in-stent stenosis”). It is believed that restenosis takes place as a natural healing reaction due to the expansion of the vessel and the mechanical action of the stent on the wall of the vessel. Due to the uncontrolled migration and proliferation of medial smooth muscle cells the vessel is again stenosed. Also, the stent can cause undesirable local thrombosis.
- Stents have been used for medical treatment since 1990. Since then, the experts deal in a large numbers of examinations and essays with the problem of complications after insertion of stents (see e.g. “Local drug delivery for prevention of restenosis” by A. Michael Lincoff et al. in Circulation 90(4), October 1994 and “New recipes for in-stent restenosis: cut, grate, roast or sandwich the neointima?” by C. Di Mario et al. in Heart 84(5), 2000).
- stent implantation Several different methods for preventing complications due to stent implantation have been proposed.
- anticoagulant and antiplatelet drugs e.g. ticlopidin or aspirin.
- the vessel can be expanded again by means of a balloon catheter. Often even bypass surgery is required.
- the stents can be coated with different substances such as heparin, collagen, fibrin or adhesion peptide coating in order to reduce the risk of restenosis. It is also known to coat the stent with DLC (“diamond-like carbon”) in order to reduce the risk of restenosis.
- DLC diamond-like carbon
- Such methods and stents are e.g. disclosed in U.S. Pat. Nos. 6,153,252, 6,140,127 and 5,591,227.
- the object of the present invention is hence to reduce complications after implantation of an intravascular stent and, more particularly, to reduce the risk of restenosis due to stent implantation.
- a more specific object of the present invention is to provide an effective method for reducing complications after implantation of an intravascular stent and, more particularly, to reduce the risk of restenosis due to stent implantation.
- Another object of the invention is to provide a method for producing an intravascular stent effectively reducing complications after implantation into a vessel and, more particularly, reducing the risk of restenosis due to stent implantation.
- Still another object of the invention is to provide an effective method for coating one or more intravascular stents with a coating substance.
- the invention is based on the knowledge that some of the complications after implantation of an intravascular stent (e.g. the risk of restenosis or in-stent stenosis) is caused by the excessive smooth muscle cell growth in the vessel wall. This excessive growth takes place when the endothelium is injured. It has been shown that it takes about two months after implantation of a stent in a human body before it is covered by neointima and endothelial cells such that a continuous cell layer is developed.
- the invention is further based on the knowledge that 17beta-estradiol (chemically described as 1,3,5(10)-estradien-3,17beta-diol having the chemical notation C 18 H 24 O 2 ) on one hand inhibits the growth of smooth muscle cells and, on the other hand, stimulates the re-endothelialization.
- the present invention make use of these effects in order to prevent restenosis and in-stent stenosis
- 17beta-estradiol is a natural estrogen produced in the body itself. Thus, there are no problems concerning the biocompatibility when using 17beat-estradiol.
- the above mentioned objects are achieved through a method for reducing complications after implantation of an intravascular stent, comprising the steps of inserting an intravascular stent into a vessel to a site of intravascular stent placement and supplying 17beta-estradiol to the site of intravascular stent placement.
- the supply of 17beta-estradiol can be effected before, during or after the implantation of the stent. However, it can be advantageous to supply 17beta-estradiol at least during the operation for implantation of the stent into the vessel or even simultaneously with the implantation of the stent into the vessel. This ensures that no additional surgical operation has to be done in order to supply the 17beta-estradiol. Furthermore, this increases the probability that the 17beta-estradiol is supplied to the proper place, namely the site of stent placement.
- the quantity of 17beta-estradiol supplied to the site of stent placement can be chosen in dependence of the estimated healing time of the vessel after implantation of the stent.
- the quantity of 17beta-estradiol is chosen such that the time of action of the 17beta-estradiol is substantially equal to the estimated healing time.
- a quantity of 10-1000 ⁇ g 17beta-estradiol can be suitable. This quantity will, among other things, depend on the use of the 17beta-estradiol as one single dose acting within a few hours or as continuous (or discontinuous) supply over a longer period of time.
- the supply of 17beta-estradiol during the implantation of the stent can be effected by using different known supply methods as used for supplying other drugs into the human body.
- a particular advantageous method is given by a further aspect of the present invention, according to which the supply of 17beta-estradiol is effected by means of a drug elution system applied to the intravascular stent. This ensures that the supply of 17beta-estradiol can be effected simultaneously with the implantation of the stent into the vessel and that the 17beta-estradiol is supplied to the proper place, namely the site of stent placement.
- the above mentioned objects are achieved through a method for producing an intravascular stent reducing complications after implantation into a vessel, comprising the steps of providing a stent body suitable for implantation and applying 17beta-estradiol to the stent body. It is important that the 17beta-estradiol is connected to the stent in such a way, that it can act in a suitable manner after implantation of the stent. This can be achieved in that the 17beta-estradiol is provided on the surface of the stent body.
- Known intravascular stents have a stent body defining an inner and an outer surface.
- Such stents are known e.g. as ring-coil stents, wire stents and tubular stents.
- the 17beta-estradiol can be provided on the inner surface and/or on the outer surface of this stent body. However, it is advantageous to provide 17beta-estradiol on the inner surface as well as on the outer surface of the stent body.
- the material of the stent body does not have suitable adhesive properties for the 17beta-estradiol.
- measures can be taken in order to improve the adhesive property.
- This can be achieved in that the surface of the stent body is provided with an adhesive layer for the 17beta-estradiol e.g. on the inner surface and/or on the outer surface. It has been found that DLC (“diamond-like carbon”) is suitable for this purpose.
- the 17beta-estradiol acts a longer period of time, it is advantageous to apply the 17beta-estradiol to the stent together with a drug elution system.
- the drug here: 17beta-estradiol
- the supply of the drug at the site of placement can be effected by elution in a defined manner as a function of time.
- Such drug elution systems are well known for other drugs and described in U.S. Pat. No. 6,153,252 which is hereby incorporated by reference. These known drug elution systems can be used in a corresponding manner for eluting 17beta-estradiol.
- the 17beta-estradiol is applied to the surface of a stent body by means of a surface coating process.
- This can be effected directly on the surface of the stent body or on a support or adhesive layer.
- a large number of different surface coating processes are known which can be used for this purpose. It has been shown that CVD processes (“chemical vapor deposition processes”) are particularly suitable. During such processes the coating substance is vaporized and is then deposited on the bodies to be coated.
- the stent body to be coated with 17beta-estradiol can be inserted together with 17beta-estradiol into a vacuum chamber.
- the 17beta-estradiol is then vaporized e.g. by heating. It has been found that it is advantageous to heat the chamber wall of the vacuum chamber (or a part of it) during this coating process thereby reducing the deposition of 17beta-estradiol on the chamber wall.
- the effectiveness of the coating process can be further increased by cooling the stents to be coated. If a plurality of stents are to be coated with 17beta-estradiol at the same time in the vacuum chamber, these stents can be cooled by means of common cooling means, e.g. a cooling water circulation system.
- the quantity of 17beta-estradiol applied to the stent In many applications it will be desirable to determine the quantity of 17beta-estradiol applied to the stent. Using a coating process this can be achieved by coating the stent with a layer of 17beta-estradiol having a predetermined thickness. This can be achieved by determining layer thickness parameters during coating. One such parameter can be defined by measuring the thickness of the layer using known methods of measuring layer thickness. However, there are also other parameters suitable for this determination, e.g. the duration of the coating process. Then the layer thickness is determined (e.g. experimentally) as a function of the duration of the coating process. Of course, further parameters (e.g.
- the coating process of one or several stents can be achieved in an arrangement comprising a vacuum chamber having a chamber wall, stent accommodation means for accommodating the stent or stents in the vacuum chamber, substance accommodation means for accommodating the coating substance in the vacuum chamber, and vaporization means for vaporizing the coating substance in the vacuum chamber to achieve a coating process through which the stents are coated with the coating substance.
- an arrangement can, of course, be used for coating stents with coating substances other than 17beta-estradiol.
- the 17beta-estradiol (if desired together with further substances) can be applied to the stents by other methods, e.g. by spraying or by dipping the stents into a solution.
- Such methods are well known for other substances and described e.g. in U.S. Pat. No. 6,153,252 incorporated herein by reference. It can be advantageous to carry out these methods in a vacuum chamber.
- All stents or stent bodies known in the prior art can be provided with 17beta-estradiol according to the present invention, provided that the 17beta-estradiol can adhere to the surface of the stent in the same way.
- Several of such known stents are mentioned in U.S. Pat. No. 6,153,252 and hereby incorporated by reference.
- FIG. 1 is a schematic illustration and shows a cross section of a blood vessel
- FIG. 2 is a perspective illustration and shows a stent coated with DLC and 17beta-estradiol
- FIG. 3 is a schematic illustration and shows a cross section of the stent of FIG. 2;
- FIG. 4 is a schematic illustration and shows a plan view of an arrangement for coating stents by means of a CVD process.
- FIG. 1 a section of a cross section of a blood vessel 10 .
- Numeral 12 designates the fat tissue in which the blood vessel is embedded.
- the outer layer (“tunica externa”) of the blood vessel 10 is designated by numeral 14 .
- An outer membrane 16 (“membrana elastica externa”) separates the outer layer 14 from a mid-layer 18 (“tunica media”).
- An inner membrane 20 (“membrana elastica interna”) separates the mid-layer 18 from an inner layer 22 (“tunica intima”).
- the inner layer consists of endothelium.
- the endothelium is a very thin layer having a monolayer of endothelial cells.
- the mid-layer 18 contains smooth muscle cells.
- the inner layer 22 of the blood vessel 10 is injured, then the mid-layer 18 is exposed to the blood flowing in the blood vessel 10 , the smooth muscle cells in the mid-layer 22 getting into contact with the blood.
- Blood comprises several substances which stimulates the growth of smooth muscle cells. This can lead to narrowing or occlusion of the blood vessel if this growth is not suppressed. This growth of smooth muscle cells can be effectively suppressed by inhibiting this growth and by fast re-endothelialization, that means healing of the inner layer 22 .
- a stent 24 With reference to FIG. 2, there is shown a stent 24 .
- This stent has a stent body 26 consisting of a mesh of stainless steel (“316L”). This is a commercially available stent intended to be crimped in a crimping device before implantation.
- the surface of the stent body 26 is coated with DLC. This is illustrated in FIG. 3 by an outer and an inner DLC-layer 28 and 30 , respectively.
- the surface of the DLC-layers 28 and 30 are coated with 17beta-estradiol. This is illustrated in FIG. 3 by an outer and an inner 17beta-estradiol layer 32 and 34 , respectively.
- FIG. 4 there is shown an arrangement for coating stents by means of a CVD process.
- the arrangement comprises a vacuum chamber 36 .
- Stent accommodation means in the form of stent supports 38 are provided in the vacuum chamber 36 .
- substance accommodation means in the form of an accommodation vessel 40 for accommodating a coating substance here: 17beta-estradiol
- the accommodation vessel 40 is adapted to be heated by a heating device illustrated by block 42 .
- the wall of the vacuum chamber 36 is adapted to be heated by a further heating device illustrated by block 44 .
- the stent supports 28 are adapted to be cooled by a cooling device illustrated by block 46 .
- the stent supports 38 are connected to a common cooling water circulation system 48 .
- the heating device 42 for heating the accommodation vessel 40 is connected to a timer 50 , by means of which the heating time of the heating device 42 is controlled.
- the stent body 26 is produced out of stainless steel. Subsequently, the stent body 26 is coated with DLC-layers 28 and 30 . This is known in the prior art and therefore not described in detail herein.
- the stent body 26 coated with DLC is inserted into one of the stent supports 38 (possibly together with further stent bodies in further stent supports 38 ).
- 17beta-estradiol is inserted into the accommodation vessel 40 in a form which is suitable for vaporization. For this purpose, the 17beta-estradiol can be dissolved in a suitable organic solvent. Subsequently, the vacuum chamber 26 is closed and a vacuum is generated in the chamber 36 .
- the stent supports 38 and, thus, the stents supported therein, are cooled to a defined temperature by means of the cooling device 46 and the cooling water circulation system 48 .
- the walls of the vacuum chamber 36 are heated to a defined temperature by means of the heating device 44 .
- the heating device 42 By means of the heating device 42 the accommodation vessel 40 and, thus, the 17beta-estradiol-solution therein, is heated to a defined temperature or by following a defined march of temperature, the timer 50 being set to switch off the heating device 42 after a predetermined time period.
- the temperatures defined by the heating devices 42 and 44 and by the cooling device 46 and the time period defined by the timer 50 are predetermined in such a manner, that the stents supported in the stent supports 38 are coated with 17beta-estradiol in a desired manner and with a desired layer thickness. These parameters can be selected such that the stent is coated with, for example, 30-50 ⁇ g 17beta-estradiol.
Abstract
This invention relates to methods and arrangement for reducing complications after implantation of an intravascular stent and, more particularly, for reducing the risk of restenosis due to stent implantation. This is achieved by using 17beta-estradiol as vessel healing substance after implantation of an intravascular stent. The 17beta-estradiol can be coated onto an intravascular stent and be included in a drug elution system applied to the intravascular stent. This can be achieved by means of a surface coating process such as CVD process. 17beta-estradiol inhibits the growth of smooth muscle cells and stimulates the re-endothelialization after implantation of an intravascular stent. The present invention makes use of these effects in order to prevent restenosis and in-stent stenosis.
Description
- This application is a continuation of application Ser. No. 09/839,249 filed Apr. 20, 2001, now U.S. Pat. No. ______.
- 1. Field
- This invention relates to a method of reducing complications after implantation of an intravascular stent and, more particularly, for reducing the risk of restenosis due to stent implantation.
- The invention further relates to a method for producing an intravascular stent reducing complications after implantation into a vessel and, more particularly, reducing the risk of restenosis due to stent implantation.
- The invention further relates to the use of vessel healing substances after implantation of an intravascular stent and, more particularly, to the use of vessel healing substances during manufacture of an intravascular stent.
- The invention finally relates to an arrangement for coating one or more intravascular stents with a coating substance.
- 2. State of the Art
- An intravascular stent is a prosthesis which may be placed within a body passageway containing endothelial cells such as any vein, artery or blood vessel within the vascular system. Typically, the stent is inserted into a vessel and placed at a site of vascular occlusion. The stent is expanded at this site in order to contact the vessel wall, thereby widening the vessel and providing mechanical support for the wall. Stents are typically manufactured from special tubes of metal or other material compositions (e.g. stainless steel, tantalum, nitinol) or from coil or plait structures of metal and/or plastics. The stents may be inserted into the vessel in different ways. Before it is inserted, the stent can e.g. be arranged on a support and crimped thereupon. The support can be a balloon catheter. The crimped stent is then transported by means of the balloon catheter into the vessel to the site of stent placement. The stent is fixed in the vessel by being expanded, e.g. by increasing the internal pressure of the balloon catheter by means of a pump, e.g. a hand pump. Thereby, the structure of the stent is deformed and the stent urges against the wall of the vessel. After the balloon catheter has been removed, the stent is dimensionally stable in the vessel. A similar process is used for inserting so-called self-expandable stents. These stents do not need any external pressure in order to expand, they expand due to restoring forces or due to the ambient conditions (flow, temperature etc.). Thus, an inserted stent expands and supports the vessel wall and can eliminate stenosis.
- However, it has been found that the presence of a stent in a vessel can result in complications, e.g. restenosis. Restenosis can e.g. take place at the ends of the stent or in the stent itself (“in-stent stenosis”). It is believed that restenosis takes place as a natural healing reaction due to the expansion of the vessel and the mechanical action of the stent on the wall of the vessel. Due to the uncontrolled migration and proliferation of medial smooth muscle cells the vessel is again stenosed. Also, the stent can cause undesirable local thrombosis.
- Stents have been used for medical treatment since 1990. Since then, the experts deal in a large numbers of examinations and essays with the problem of complications after insertion of stents (see e.g. “Local drug delivery for prevention of restenosis” by A. Michael Lincoff et al. in Circulation 90(4), October 1994 and “New recipes for in-stent restenosis: cut, grate, roast or sandwich the neointima?” by C. Di Mario et al. in Heart 84(5), 2000).
- Several different methods for preventing complications due to stent implantation have been proposed. To address the problem of thrombosis the person receives anticoagulant and antiplatelet drugs (e.g. ticlopidin or aspirin). To address the problem of restenosis and in-stent stenosis the vessel can be expanded again by means of a balloon catheter. Often even bypass surgery is required. Furthermore, the stents can be coated with different substances such as heparin, collagen, fibrin or adhesion peptide coating in order to reduce the risk of restenosis. It is also known to coat the stent with DLC (“diamond-like carbon”) in order to reduce the risk of restenosis.
- Such methods and stents are e.g. disclosed in U.S. Pat. Nos. 6,153,252, 6,140,127 and 5,591,227.
- Prior attempts to reduce complications after implantation of an intravascular stent could not reduce the risk of restenosis in a satisfactory way. Restenosis and in-stent stenosis are still considered unsolved problems. For example, in-stent stenosis is still observed in 20%-30% of the cases.
- The object of the present invention is hence to reduce complications after implantation of an intravascular stent and, more particularly, to reduce the risk of restenosis due to stent implantation.
- A more specific object of the present invention is to provide an effective method for reducing complications after implantation of an intravascular stent and, more particularly, to reduce the risk of restenosis due to stent implantation.
- Another object of the invention is to provide a method for producing an intravascular stent effectively reducing complications after implantation into a vessel and, more particularly, reducing the risk of restenosis due to stent implantation.
- Still another object of the invention is to provide an effective method for coating one or more intravascular stents with a coating substance.
- In accordance with the invention these objects are achieved by using 17beta-estradiol as a vessel healing substance after implantation of an intravascular stent.
- The invention is based on the knowledge that some of the complications after implantation of an intravascular stent (e.g. the risk of restenosis or in-stent stenosis) is caused by the excessive smooth muscle cell growth in the vessel wall. This excessive growth takes place when the endothelium is injured. It has been shown that it takes about two months after implantation of a stent in a human body before it is covered by neointima and endothelial cells such that a continuous cell layer is developed.
- The invention is further based on the knowledge that 17beta-estradiol (chemically described as 1,3,5(10)-estradien-3,17beta-diol having the chemical notation C18H24O2) on one hand inhibits the growth of smooth muscle cells and, on the other hand, stimulates the re-endothelialization. The present invention make use of these effects in order to prevent restenosis and in-stent stenosis
- 17beta-estradiol is a natural estrogen produced in the body itself. Thus, there are no problems concerning the biocompatibility when using 17beat-estradiol.
- Thus, in accordance with one aspect of the invention the above mentioned objects are achieved through a method for reducing complications after implantation of an intravascular stent, comprising the steps of inserting an intravascular stent into a vessel to a site of intravascular stent placement and supplying 17beta-estradiol to the site of intravascular stent placement.
- The supply of 17beta-estradiol can be effected before, during or after the implantation of the stent. However, it can be advantageous to supply 17beta-estradiol at least during the operation for implantation of the stent into the vessel or even simultaneously with the implantation of the stent into the vessel. This ensures that no additional surgical operation has to be done in order to supply the 17beta-estradiol. Furthermore, this increases the probability that the 17beta-estradiol is supplied to the proper place, namely the site of stent placement.
- The quantity of 17beta-estradiol supplied to the site of stent placement can be chosen in dependence of the estimated healing time of the vessel after implantation of the stent. Preferably, the quantity of 17beta-estradiol is chosen such that the time of action of the 17beta-estradiol is substantially equal to the estimated healing time. Depending on the individual case, a quantity of 10-1000 μg 17beta-estradiol can be suitable. This quantity will, among other things, depend on the use of the 17beta-estradiol as one single dose acting within a few hours or as continuous (or discontinuous) supply over a longer period of time.
- The supply of 17beta-estradiol during the implantation of the stent can be effected by using different known supply methods as used for supplying other drugs into the human body. A particular advantageous method is given by a further aspect of the present invention, according to which the supply of 17beta-estradiol is effected by means of a drug elution system applied to the intravascular stent. This ensures that the supply of 17beta-estradiol can be effected simultaneously with the implantation of the stent into the vessel and that the 17beta-estradiol is supplied to the proper place, namely the site of stent placement.
- In accordance with a further aspect of the invention the above mentioned objects are achieved through a method for producing an intravascular stent reducing complications after implantation into a vessel, comprising the steps of providing a stent body suitable for implantation and applying 17beta-estradiol to the stent body. It is important that the 17beta-estradiol is connected to the stent in such a way, that it can act in a suitable manner after implantation of the stent. This can be achieved in that the 17beta-estradiol is provided on the surface of the stent body.
- Known intravascular stents have a stent body defining an inner and an outer surface. Such stents are known e.g. as ring-coil stents, wire stents and tubular stents. The 17beta-estradiol can be provided on the inner surface and/or on the outer surface of this stent body. However, it is advantageous to provide 17beta-estradiol on the inner surface as well as on the outer surface of the stent body.
- In some cases, the material of the stent body does not have suitable adhesive properties for the 17beta-estradiol. In these cases, measures can be taken in order to improve the adhesive property. This can be achieved in that the surface of the stent body is provided with an adhesive layer for the 17beta-estradiol e.g. on the inner surface and/or on the outer surface. It has been found that DLC (“diamond-like carbon”) is suitable for this purpose.
- If it is desired to let the 17beta-estradiol act a longer period of time, it is advantageous to apply the 17beta-estradiol to the stent together with a drug elution system. In such drug elution systems the drug (here: 17beta-estradiol) is bonded in other substances and the supply of the drug at the site of placement can be effected by elution in a defined manner as a function of time. Such drug elution systems are well known for other drugs and described in U.S. Pat. No. 6,153,252 which is hereby incorporated by reference. These known drug elution systems can be used in a corresponding manner for eluting 17beta-estradiol.
- In accordance with a further aspect of the invention the 17beta-estradiol is applied to the surface of a stent body by means of a surface coating process. This can be effected directly on the surface of the stent body or on a support or adhesive layer. A large number of different surface coating processes are known which can be used for this purpose. It has been shown that CVD processes (“chemical vapor deposition processes”) are particularly suitable. During such processes the coating substance is vaporized and is then deposited on the bodies to be coated. For this purpose the stent body to be coated with 17beta-estradiol can be inserted together with 17beta-estradiol into a vacuum chamber. The 17beta-estradiol is then vaporized e.g. by heating. It has been found that it is advantageous to heat the chamber wall of the vacuum chamber (or a part of it) during this coating process thereby reducing the deposition of 17beta-estradiol on the chamber wall. The effectiveness of the coating process can be further increased by cooling the stents to be coated. If a plurality of stents are to be coated with 17beta-estradiol at the same time in the vacuum chamber, these stents can be cooled by means of common cooling means, e.g. a cooling water circulation system.
- In many applications it will be desirable to determine the quantity of 17beta-estradiol applied to the stent. Using a coating process this can be achieved by coating the stent with a layer of 17beta-estradiol having a predetermined thickness. This can be achieved by determining layer thickness parameters during coating. One such parameter can be defined by measuring the thickness of the layer using known methods of measuring layer thickness. However, there are also other parameters suitable for this determination, e.g. the duration of the coating process. Then the layer thickness is determined (e.g. experimentally) as a function of the duration of the coating process. Of course, further parameters (e.g. temperature of the 17beta-estradiol, of the stents and of the walls of the vacuum chamber) having an influence on this function have to be taken into consideration. These further parameters can be kept constant such that the layer thickness will depend only on the duration of the coating process. By this method the layer thickness can be determined and controlled very exactly.
- Thus, in one aspect of the invention the coating process of one or several stents can be achieved in an arrangement comprising a vacuum chamber having a chamber wall, stent accommodation means for accommodating the stent or stents in the vacuum chamber, substance accommodation means for accommodating the coating substance in the vacuum chamber, and vaporization means for vaporizing the coating substance in the vacuum chamber to achieve a coating process through which the stents are coated with the coating substance. Such an arrangement can, of course, be used for coating stents with coating substances other than 17beta-estradiol.
- However, it shall be noted that the 17beta-estradiol (if desired together with further substances) can be applied to the stents by other methods, e.g. by spraying or by dipping the stents into a solution. Such methods are well known for other substances and described e.g. in U.S. Pat. No. 6,153,252 incorporated herein by reference. It can be advantageous to carry out these methods in a vacuum chamber.
- All stents or stent bodies known in the prior art can be provided with 17beta-estradiol according to the present invention, provided that the 17beta-estradiol can adhere to the surface of the stent in the same way. Several of such known stents are mentioned in U.S. Pat. No. 6,153,252 and hereby incorporated by reference.
- Further objects and features of the invention will be apparent to a person skilled in the art from the following specification of preferred embodiments when read in conjunction with the appended claims.
- The invention and its mode of operation will be more clearly understood from the following detailed description when read with the appended drawings in which:
-
- FIG. 1 is a schematic illustration and shows a cross section of a blood vessel;
-
- FIG. 2 is a perspective illustration and shows a stent coated with DLC and 17beta-estradiol;
-
- FIG. 3 is a schematic illustration and shows a cross section of the stent of FIG. 2; and
-
- FIG. 4 is a schematic illustration and shows a plan view of an arrangement for coating stents by means of a CVD process.
- Referring now to FIG. 1, for better understanding there is shown a section of a cross section of a
blood vessel 10. In this case it is the wall construction of a muscular artery vessel.Numeral 12 designates the fat tissue in which the blood vessel is embedded. The outer layer (“tunica externa”) of theblood vessel 10 is designated bynumeral 14. An outer membrane 16 (“membrana elastica externa”) separates theouter layer 14 from a mid-layer 18 (“tunica media”). An inner membrane 20 (“membrana elastica interna”) separates the mid-layer 18 from an inner layer 22 (“tunica intima”). The inner layer consists of endothelium. The endothelium is a very thin layer having a monolayer of endothelial cells. The mid-layer 18 contains smooth muscle cells. - If the
inner layer 22 of theblood vessel 10 is injured, then the mid-layer 18 is exposed to the blood flowing in theblood vessel 10, the smooth muscle cells in the mid-layer 22 getting into contact with the blood. Blood comprises several substances which stimulates the growth of smooth muscle cells. This can lead to narrowing or occlusion of the blood vessel if this growth is not suppressed. This growth of smooth muscle cells can be effectively suppressed by inhibiting this growth and by fast re-endothelialization, that means healing of theinner layer 22. - With reference to FIG. 2, there is shown a
stent 24. This stent has astent body 26 consisting of a mesh of stainless steel (“316L”). This is a commercially available stent intended to be crimped in a crimping device before implantation. The surface of thestent body 26 is coated with DLC. This is illustrated in FIG. 3 by an outer and an inner DLC-layer layers estradiol layer - With reference to FIG. 4, there is shown an arrangement for coating stents by means of a CVD process. The arrangement comprises a
vacuum chamber 36. Stent accommodation means in the form of stent supports 38 are provided in thevacuum chamber 36. (In the schematic illustration of FIG. 4 there are shown, as example, four such stent supports 38.) Furthermore, substance accommodation means in the form of anaccommodation vessel 40 for accommodating a coating substance (here: 17beta-estradiol) is provided in thevacuum chamber 36. Theaccommodation vessel 40 is adapted to be heated by a heating device illustrated byblock 42. The wall of thevacuum chamber 36 is adapted to be heated by a further heating device illustrated byblock 44. The stent supports 28 are adapted to be cooled by a cooling device illustrated byblock 46. The stent supports 38 are connected to a common coolingwater circulation system 48. - The
heating device 42 for heating theaccommodation vessel 40 is connected to atimer 50, by means of which the heating time of theheating device 42 is controlled. - In order to manufacture a stent according to the method described herein, at first the
stent body 26 is produced out of stainless steel. Subsequently, thestent body 26 is coated with DLC-layers stent body 26 coated with DLC is inserted into one of the stent supports 38 (possibly together with further stent bodies in further stent supports 38). 17beta-estradiol is inserted into theaccommodation vessel 40 in a form which is suitable for vaporization. For this purpose, the 17beta-estradiol can be dissolved in a suitable organic solvent. Subsequently, thevacuum chamber 26 is closed and a vacuum is generated in thechamber 36. - The stent supports38 and, thus, the stents supported therein, are cooled to a defined temperature by means of the
cooling device 46 and the coolingwater circulation system 48. The walls of thevacuum chamber 36 are heated to a defined temperature by means of theheating device 44. By means of theheating device 42 theaccommodation vessel 40 and, thus, the 17beta-estradiol-solution therein, is heated to a defined temperature or by following a defined march of temperature, thetimer 50 being set to switch off theheating device 42 after a predetermined time period. - The temperatures defined by the
heating devices device 46 and the time period defined by thetimer 50 are predetermined in such a manner, that the stents supported in the stent supports 38 are coated with 17beta-estradiol in a desired manner and with a desired layer thickness. These parameters can be selected such that the stent is coated with, for example, 30-50 μg 17beta-estradiol. - When a stent coated with 17beta-estradiol is inserted into a blood vessel, it is ensured that the 17beta-estradiol is supplied to the site of the stent placement. The supply of 17beta-estradiol is then effected simultaneous with the implantation of the stent. By properly setting the parameters it can be ensured that the quantity of 17beta-estradiol is chosen to substantially correspond to the healing time of the vessel after implantation of the stent.
Claims (31)
1. A method for reducing complications after implantation of an intravascular stent, comprising the steps of:
inserting an intravascular stent into a vessel to a site of intravascular stent placement at a site of vessel stenosis; and
supplying 17beta-estradiol to said site of intravascular stent placement.
2. The method of claim 1 , wherein said supply of 17beta-estradiol is effected during an operation for implantation of said intravascular stent into said vessel.
3. The method of claim 2 , wherein said supply of 17beta-estradiol is effected simultaneous with said implantation of said intravascular stent into said vessel.
4. The method of claim 1 , wherein said 17beta-estradiol is supplied in a certain quantity and said quantity is chosen in dependence of the estimated healing time of said vessel after implantation of said intravascular stent.
5. The method of claim 4 , wherein said quantity of said 17beta-estradiol is chosen such that the time of action of said 17beta-estradiol is substantially equal to said estimated healing time.
6. The method of claim 1 , wherein said supply of said 17beta-estradiol is effected by means of a drug elution system applied to said intravascular stent.
7. Use of 17beta-estradiol as vessel healing substance after implantation of an intravascular stent.
8. A method for producing an intravascular stent reducing complications after implantation into a vessel, comprising the steps of:
providing a stent body suitable for implantation; and
applying 17beta-estradiol to said stent body.
9. The method of claim 8 , wherein said stent body has a surface and said 17beta-estradiol is provided on said surface of said stent body.
10. The method of claim 9 , comprising the steps of:
providing a stent body defining an inner surface and an outer surface; and
providing 17beta-estradiol on said inner surface and/or said outer surface of said stent body.
11. The method of claim 10 , wherein said stent body is provided with an adhesive layer for said 17beta-estradiol on said inner surface and/or said outer surface.
12. The method of claim 11 , wherein said adhesive layer contains DLC (“diamond-like carbon”).
13. The method of claim 8 , wherein said 17beta-estradiol is applied to said surface of said stent body by means of a surface coating process.
14. The method of claim 13 , wherein said surface coating process is a CVD process (“chemical vapor deposition process”).
15. The method of claim 14 , comprising the steps of:
inserting said stent body to be coated with 17beta-estradiol together with said 17beta-estradiol into a vacuum chamber; and
vaporizing said 17beta-estradiol.
16. The method of claim 15 , wherein said vacuum chamber has a chamber wall, at least a part of said chamber wall being heated.
17. The method of claim 15 , wherein said stent body to be coated with 17beta-estradiol is cooled.
18. The method of claim 15 , wherein a plurality of stent bodies to be coated with 17beta-estradiol is provided in said vacuum chamber at the same time.
19. The method of claim 18 , wherein said stent bodies to be coated with 17beta-estradiol are cooled by means of common cooling means.
20. The method of claim 13 , wherein said stent body is coated with 17beta-estradiol to obtain a layer of 17beta-estradiol having a predetermined thickness.
21. The method of claim 20 , wherein said thickness of said layer of 17beta-estradiol is determined by means of layer thickness parameters.
22. The method of claim 21 , wherein one of said layer thickness parameters is the duration of said coating process.
23. The method of claim 8 , wherein a drug elution system is applied together with 17beta-estradiol to said stent body to be provided with 17beta-estradiol.
24. An arrangement for coating one or more intravascular stents with a therapeutic coating substance, comprising:
a vacuum chamber having a chamber wall;
stent accommodation means for accommodating said stent or said stents in said vacuum chamber;
substance accommodation means for accommodating said coating substance in said vacuum chamber; and
vaporization means for vaporizing said coating substance in said vacuum chamber to achieve a coating process through which said one or more stents are coated with said coating substance.
25. The arrangement of claim 24 , further comprising heating means for heating at least a part of said chamber wall of said vacuum chamber.
26. The arrangement of claim 24 , further comprising cooling means for cooling said stent or said stents to be coated.
27. The arrangement of claim 24 , further comprising layer thickness determining means for determining a layer thickness of said coating substance on said stent or said stents.
28. The arrangement of claim 27 , wherein said layer thickness determining means comprise timer means arranged to determine the duration of said coating process.
29. The arrangement of claim 24 , wherein said coating substance contains 17beta-estradiol.
30. The intravascular stent of claim 29 , comprising:
a stent body having an inner surface and an outer surface; and
17beta-estradiol provided on said inner surface and/or said outer surface of said stent body.
31. The intravascular stent of claim 30, wherein said stent body is provided with an adhesive layer for said 17beta-estradiol on said inner surface and/or said outer surface.
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US10/087,065 US20020111670A1 (en) | 2001-02-13 | 2002-02-27 | Method and intravascular stent for reducing complications after implantation of an intravascular stent |
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US10/087,065 US20020111670A1 (en) | 2001-02-13 | 2002-02-27 | Method and intravascular stent for reducing complications after implantation of an intravascular stent |
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Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6692483B2 (en) | 1996-11-04 | 2004-02-17 | Advanced Stent Technologies, Inc. | Catheter with attached flexible side sheath |
US6835203B1 (en) | 1996-11-04 | 2004-12-28 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US7591846B2 (en) | 1996-11-04 | 2009-09-22 | Boston Scientific Scimed, Inc. | Methods for deploying stents in bifurcations |
US6325826B1 (en) | 1998-01-14 | 2001-12-04 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US6599316B2 (en) | 1996-11-04 | 2003-07-29 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US8211167B2 (en) | 1999-12-06 | 2012-07-03 | Boston Scientific Scimed, Inc. | Method of using a catheter with attached flexible side sheath |
US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
US7655030B2 (en) | 2003-07-18 | 2010-02-02 | Boston Scientific Scimed, Inc. | Catheter balloon systems and methods |
US6471979B2 (en) * | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
US8617231B2 (en) | 2001-05-18 | 2013-12-31 | Boston Scientific Scimed, Inc. | Dual guidewire exchange catheter system |
US6695920B1 (en) | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US20080145402A1 (en) * | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
US7326245B2 (en) * | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7291165B2 (en) | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7445629B2 (en) * | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
DE10228078B3 (en) * | 2002-06-18 | 2004-02-26 | Innovent E.V. Technologieentwicklung | Composition for coating implants, e.g. stents, to inhibit smooth muscle cell proliferation and restenosis, comprising mixture of low-molecular or oligomeric estrogen ester and estrogen |
AU2003272378A1 (en) * | 2002-09-12 | 2004-04-30 | X-Cell Medical, Inc. | Apparatus and method for delivering compounds to a living organism |
WO2004043507A1 (en) * | 2002-11-07 | 2004-05-27 | Carbon Medical Technologies, Inc. | Biocompatible medical device coatings |
US7074276B1 (en) | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US6957152B1 (en) | 2002-12-30 | 2005-10-18 | Advanced Cardiovascular Systems, Inc. | System and computer-based method for tracking an implantable medical device characteristic during a coating process |
US7494497B2 (en) * | 2003-01-02 | 2009-02-24 | Boston Scientific Scimed, Inc. | Medical devices |
US7001421B2 (en) * | 2003-02-28 | 2006-02-21 | Medtronic Vascular, Inc. | Stent with phenoxy primer coating |
AU2004237574A1 (en) * | 2003-03-13 | 2004-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
JP2005046611A (en) * | 2003-07-01 | 2005-02-24 | Medtronic Vascular Inc | Adhesive layer activated by energy for stent coated with polymer containing medicament |
JP4732346B2 (en) * | 2003-08-19 | 2011-07-27 | バイエル・マテリアルサイエンス・アクチェンゲゼルシャフト | Polymeric drug elution system for medical devices |
US8298280B2 (en) | 2003-08-21 | 2012-10-30 | Boston Scientific Scimed, Inc. | Stent with protruding branch portion for bifurcated vessels |
US7344557B2 (en) | 2003-11-12 | 2008-03-18 | Advanced Stent Technologies, Inc. | Catheter balloon systems and methods |
US7435788B2 (en) | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US9561309B2 (en) | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
CA2559540A1 (en) | 2004-06-08 | 2005-12-29 | Advanced Stent Technologies, Inc. | Stent with protruding branch portion for bifurcated vessels |
US20050287184A1 (en) | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
WO2006026725A2 (en) | 2004-08-31 | 2006-03-09 | C.R. Bard, Inc. | Self-sealing ptfe graft with kink resistance |
AT501408B1 (en) | 2004-12-07 | 2011-03-15 | Physikalisches Buero Steinmueller Gmbh | BIOLOGICAL SURFACES |
CA2611119A1 (en) * | 2005-06-08 | 2006-12-14 | C.R. Bard Inc. | Grafts and stents having inorganic bio-compatible calcium salt |
CA2610896C (en) | 2005-06-17 | 2014-07-08 | C.R. Bard, Inc. | Vascular graft with kink resistance after clamping |
US7823533B2 (en) | 2005-06-30 | 2010-11-02 | Advanced Cardiovascular Systems, Inc. | Stent fixture and method for reducing coating defects |
US7735449B1 (en) | 2005-07-28 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Stent fixture having rounded support structures and method for use thereof |
DE202006008702U1 (en) * | 2006-05-24 | 2007-09-27 | Biomed Est. | Orthopedic anchoring system, for fixation of long bone e.g. tibia, fracture, has two lateral implants, where each implant includes base and post that are arranged orthogonally and coated with active substances |
JP5118042B2 (en) * | 2005-09-06 | 2013-01-16 | シー・アール・バード・インコーポレーテッド | Implant for transplantation containing drug crystals |
JP5280852B2 (en) | 2005-11-09 | 2013-09-04 | シー・アール・バード・インコーポレーテッド | Grafts and stent grafts with radiopaque markers |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US8821561B2 (en) | 2006-02-22 | 2014-09-02 | Boston Scientific Scimed, Inc. | Marker arrangement for bifurcation catheter |
US7985441B1 (en) | 2006-05-04 | 2011-07-26 | Yiwen Tang | Purification of polymers for coating applications |
US8003156B2 (en) | 2006-05-04 | 2011-08-23 | Advanced Cardiovascular Systems, Inc. | Rotatable support elements for stents |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
EP2079575B1 (en) | 2006-10-12 | 2021-06-02 | C.R. Bard, Inc. | Methods for making vascular grafts with multiple channels |
US7713541B1 (en) | 2006-11-21 | 2010-05-11 | Abbott Cardiovascular Systems Inc. | Zwitterionic terpolymers, method of making and use on medical devices |
US8486134B2 (en) | 2007-08-01 | 2013-07-16 | Boston Scientific Scimed, Inc. | Bifurcation treatment system and methods |
US8936567B2 (en) | 2007-11-14 | 2015-01-20 | Boston Scientific Scimed, Inc. | Balloon bifurcated lumen treatment |
WO2009088953A2 (en) | 2007-12-31 | 2009-07-16 | Boston Scientific Scimed Inc. | Bifurcation stent delivery system and methods |
DE112009001065A5 (en) | 2008-05-31 | 2011-04-14 | Lothar Sellin | Medical device and method for its manufacture |
US8377108B2 (en) | 2008-06-02 | 2013-02-19 | Boston Scientific Scimed, Inc. | Staggered two balloon bifurcation catheter assembly and methods |
JP5662310B2 (en) | 2008-06-05 | 2015-01-28 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | Shrinkable branch device and method of manufacturing the same |
US11298252B2 (en) | 2008-09-25 | 2022-04-12 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
US8769796B2 (en) | 2008-09-25 | 2014-07-08 | Advanced Bifurcation Systems, Inc. | Selective stent crimping |
CN102215780B (en) | 2008-09-25 | 2015-10-14 | 高级分支系统股份有限公司 | Part crimped stent |
WO2011089620A2 (en) * | 2010-01-25 | 2011-07-28 | Concept Medical Research Private Limited | A method and an insert able medical device for delivering one or more pro-healing agents to a target site within a blood vessel post-deployment of a stent |
DE202011111004U1 (en) | 2010-03-24 | 2018-04-17 | Advanced Bifurcation Systems, Inc. | Systems for the ostial stenting of a bifurcation |
WO2011119883A1 (en) | 2010-03-24 | 2011-09-29 | Advanced Bifurcation Systems, Inc. | Stent alignment during treatment of a bifurcation |
EP4275660A3 (en) | 2010-03-24 | 2024-01-17 | Advanced Bifurcation Systems Inc. | Selective stent crimping |
CA2794080A1 (en) | 2010-03-24 | 2011-09-29 | Advanced Bifurcation Systems, Inc. | System and methods for treating a bifurcation |
WO2012109382A2 (en) | 2011-02-08 | 2012-08-16 | Advanced Bifurcation Systems, Inc. | Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use |
EP2672932B1 (en) | 2011-02-08 | 2018-09-19 | Advanced Bifurcation Systems, Inc. | System for treating a bifurcation with a fully crimped stent |
CN107811726B (en) * | 2016-09-13 | 2020-09-25 | 先健科技(深圳)有限公司 | Covered stent |
CN109419570A (en) * | 2017-08-30 | 2019-03-05 | 先健科技(深圳)有限公司 | Overlay film frame and preparation method thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5866561A (en) * | 1997-08-21 | 1999-02-02 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
US6197013B1 (en) * | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
US6471979B2 (en) * | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9614950D0 (en) * | 1996-07-16 | 1996-09-04 | Anson Medical Ltd | A ductus stent and delivery catheter |
WO1998056312A1 (en) * | 1997-06-13 | 1998-12-17 | Scimed Life Systems, Inc. | Stents having multiple layers of biodegradable polymeric composition |
DE19744135C1 (en) * | 1997-09-29 | 1999-03-25 | Schering Ag | Medical implants coated with epothilone |
JP4583597B2 (en) * | 1998-05-05 | 2010-11-17 | ボストン サイエンティフィック リミテッド | Smooth end stent |
JP4439734B2 (en) * | 1998-06-03 | 2010-03-24 | ブルー・メディカル・デバイシーズ・ベスローテン・フェンノートシャップ | Stent with diamond-like coating |
CA2338788A1 (en) * | 1998-09-02 | 2000-03-09 | Scimed Life Systems, Inc. | Drug delivery device for stent |
MXPA02003009A (en) * | 1999-09-21 | 2005-02-17 | Inst Cardiologie Montreal | Local delivery of 17-beta estradiol for preventing vascular intima hyperplasia and for improving vascular endothelium function after vascular injury. |
AU2609401A (en) * | 1999-12-29 | 2001-07-09 | Nicholas Kipshidze | Apparatus and method for delivering compounds to a living organism |
GB0100760D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
-
2001
- 2001-02-13 DE DE10107795.5A patent/DE10107795B4/en not_active Expired - Fee Related
- 2001-04-20 US US09/839,249 patent/US6383215B1/en not_active Expired - Fee Related
-
2002
- 2002-02-11 WO PCT/EP2002/001388 patent/WO2002064185A2/en not_active Application Discontinuation
- 2002-02-27 US US10/087,065 patent/US20020111670A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6197013B1 (en) * | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
US5866561A (en) * | 1997-08-21 | 1999-02-02 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
US6471979B2 (en) * | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
Also Published As
Publication number | Publication date |
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WO2002064185A3 (en) | 2003-02-20 |
DE10107795A1 (en) | 2002-08-29 |
US6383215B1 (en) | 2002-05-07 |
DE10107795B4 (en) | 2014-05-15 |
WO2002064185A2 (en) | 2002-08-22 |
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