US20020151913A1 - Wire connector structures for tubular grafts - Google Patents
Wire connector structures for tubular grafts Download PDFInfo
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- US20020151913A1 US20020151913A1 US10/171,425 US17142502A US2002151913A1 US 20020151913 A1 US20020151913 A1 US 20020151913A1 US 17142502 A US17142502 A US 17142502A US 2002151913 A1 US2002151913 A1 US 2002151913A1
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- connector
- graft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/064—Blood vessels with special features to facilitate anastomotic coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
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- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Connector structures are provided for attaching elongated flexible tubular grafts to the body organ tubing of a patient. The connector structures are formed from wire. A first set of connector wires may be disposed around the periphery of one end of an elongated flexible tubular graft. A second set can be disposed around the periphery of the elongated flexible tubular graft spaced sufficiently from the first set of connector wires to define a gap. The portion of body organ tubing to which the elongated flexible tubular graft is to be attached is received in the gap and engaged by the first and second sets of connector wires. The wires may be formed in the shape of loops. If desired, hooks may be provided on the ends of the wires. The wires may be curved to accommodate attachment of the graft to tubular body organ tubing. The wires may also be formed in annular shapes. The connector structures may be formed as stand-alone ring-shaped connectors. Obliquely-angled connections between grafts and body organ tubing may be made using the connector structures.
Description
- This application is a continuation of U.S. patent application Ser. No. 09/505,540, filed Feb. 17, 2000, which is a continuation of U.S. patent application Ser. No. 08/946,742, filed Oct. 9, 1997 (now U.S. Pat. No. 6,074,416). Both of these prior applications are hereby incorporated by reference herein in their entireties.
- This invention relates to tubular graft structures for replacing or supplementing a patient's natural body organ tubing. More particularly, the invention relates to structures for connecting the ends of such tubular graft structures to body organ tubing.
- A patient's weakened or diseased body organ tubing can often be repaired by replacing or supplementing the patient's existing natural body organ tubing with an artificial graft structure. One suitable type of artificial graft structure uses a tubular nitinol mesh frame covered with a silicone coating, as described in Goldsteen et al. U.S. Pat. No. 5,976,178. Such grafts are highly flexible, so they recover their shape after being stretched. Accordingly, a graft of this type may be stretched axially to reduce its radial dimension and then installed in a patient intraluminally (e.g., through an existing vein or artery). Once delivered to the proper location within the patient, the axially stretched graft may be released, whereupon it expands to regain its original shape.
- In addition, flexible artificial grafts may be made distensible like natural body organ tubing to help reduce clot formation when used in vascular applications. Flexible artificial grafts may also be made biocompatible by adjusting their porosity and the composition of their coatings.
- Various connector structures may be used to attach flexible artificial grafts to a patient's body organ tubing. For example, a graft may be surgically attached to a patient's body organ tubing with sutures. To install a graft intraluminally, a pronged ring may be expanded from within the end of the graft, thereby piercing the graft and attaching it to surrounding body organ tubing. Barbed flaps and wire hooks may also be used to attach grafts to body organ tubing. Connector structures of these types and other suitable connector structures are described in the above-mentioned Goldsteen et al. U.S. Pat. No. 5,976,178 and in Bachinski et al. U.S. Pat. No. 6,036,702.
- Although connector structures of these types have various useful features, it would be desirable if connector structures with other features were available.
- It is therefore an object of the present invention to provide improved connector structures for attaching grafts to a patient's body organ tubing.
- This and other objects of the invention are accomplished in accordance with the principles of the present invention by providing connectors for attaching flexible graft structures to body organ tubing. The connectors may be entirely or nearly entirely from wire. The flexibility of the wire allows the connectors to be radially contracted during intraluminal insertion into a patient and subsequently radially expanded at the installation site. In addition, the flexibility of the structures makes it possible to match the compliance or flexibility characteristics of the connector with the compliance of the body organ tubing and artificial graft structures at the attachment site.
- To form a secure connection between the graft and the body organ tubing, the wire for the connectors can be arranged in two opposing groups of wires near the end of the graft. The wires in the first of the two groups are arranged about the periphery of the end of the graft. The wires in the second group are spaced by a gap from the wires in the first group along the longitudinal axis of the graft. The body organ tubing is held in the gap by the two opposing groups of wires.
- The wires in the connectors may be loops or may be individual wires. The wires may also be curved to accommodate connections between grafts and natural body organ tubing that is tubular in shape.
- If desired, the connectors may be used to form non-right-angle connections between grafts and body organ tubing.
- The connectors may also be annular in shape. Such annular connectors may be formed by molding a heat-sensitive wire mesh over an appropriate mandrel and heat treating the wire.
- Further features of the invention, its nature and various advantages will be more apparent from the accompanying drawings and the following detailed description of the preferred embodiments.
- FIG. 1 is a partially cut-away perspective view of an artificial graft structure attached to two sections of body organ tubing with illustrative connectors in accordance with the present invention.
- FIG. 2 is a partly-sectional side view of an illustrative graft having wire connectors that are engaging a portion of body organ tubing in accordance with the present invention.
- FIG. 3 is a side view of an illustrative graft with wire connectors in accordance with the present invention.
- FIGS. 4a and 4 b are side views of portions of illustrative grafts having wire connectors that are interwoven and attached to the wire mesh of a graft in accordance with the present invention.
- FIG. 5 is a side view of a portion of an illustrative graft having a wire connector attached at points of the mesh other than the wire intersection points of the mesh in accordance with the present invention.
- FIGS. 6a, 6 b, and 6 c are perspective views of illustrative hook structures for use with the connectors of the present invention.
- FIG. 7a is a perspective view of an illustrative flattened portion of a wire connector in accordance with the present invention.
- FIG. 7b is a perspective view of an illustrative flattened and hooked portion of a wire connector in accordance with the present invention.
- FIG. 8 is a perspective view of an illustrative webbed wire connector structure in accordance with the present invention.
- FIG. 9 is a side view of an illustrative graft with looped wire connectors in accordance with the present invention.
- FIGS. 10a, 10 b, and 10 c are side views of a graft with illustrative connector structures in accordance with the present invention in which the use of a sheath to attach the graft to a portion of body organ tubing is shown.
- FIG. 11 is an end sectional view of an illustrative connector arrangement in accordance with the present invention in which the connector wires are curved to accommodate the curvature of the tubular body organ tubing to which the graft is connected.
- FIG. 12 is a sectional view taken along the line12-12 in FIG. 11.
- FIG. 13 is an end sectional view of another illustrative connector arrangement in accordance with the present invention in which the connector wires are curved to accommodate the curvature of the tubular body organ tubing to which the graft is connected.
- FIG. 14 is a sectional view taken along the line14-14 in FIG. 13.
- FIG. 15 is an end sectional view of still another illustrative connector arrangement in accordance with the present invention in which the connector wires are curved to accommodate the curvature of the tubular body organ tubing to which the graft is connected.
- FIG. 16 is a sectional view taken along the line16-16 in FIG. 15.
- FIGS. 17a and 17 b are side views of illustrative annularly-shaped wire connectors in accordance with the present invention.
- FIGS. 18a and 18 b are side views of illustrative steps involved in installing wire connector structures such as the connector structures of FIGS. 17a and 17 b.
- FIGS. 19a and 19 b are side and top views, respectively, of an illustrative right-angle connection between a graft and a length of body organ tubing in accordance with the present invention.
- FIGS. 20a and 20 b are side and top views, respectively, of an illustrative non-right-angle connection between a graft and a length of body organ tubing in accordance with the present invention.
- FIG. 21 is a perspective view of a non-right-angled end of a graft having illustrative connectors in accordance with the present invention.
- FIG. 22 is a perspective view of the graft of FIG. 21 connected to a length of body organ tubing.
- FIG. 23 is a perspective view of a length of natural body tubing to which two illustrative ring-shaped wire connector structures have been attached in accordance with the present invention.
- A flexible
artificial graft 30 connected tobody organ tubing 32 withillustrative wire connectors 34 in accordance with the present invention is shown in FIG. 1.Graft 30 may be a structure formed from aflexible coating 36 covering aframe 38. The preferred materials for formingframe 38 ofgraft 30 are metals, although polymeric materials may also be used. The presently most preferred material is a braid of nitinol wire.Wire connectors 34 are preferably formed from the same type of flexible material as frame 38 (e.g., nitinol wire). Nitinol wire is heat sensitive, soconnectors 34 of various shapes may be formed by bending the wire of a given connector into a desired shape and applying a heat treatment to set the wire in that shape. -
Coating 36 is preferably an elastic biocompatible material such as silicone, which fills the apertures formed by the wires inframe 38. Other materials that may be used for coating 36 include polymeric materials such as stretchable urethane, stretchable polytetrafluoroethylene (PTFE), natural rubber, and the like. - If desired, coating36 can be formed with microscopic pores to help improve biocompatibility. A preferred method of providing a desired porosity is to make
coating 36 from an elastic material that is mixed with particles of a material that can be removed (e.g., by vaporization) after coating 36 has been applied toframe 38. When the particles are removed, voids are left in coating 36 that give it porosity. -
Graft 30 may be provided with additional coatings such as medicated coatings, hydrophilic coatings, smoothing coatings, collagen coatings, human cell seeding coatings, etc., as described in the above-mentioned Goldsteen et al. U.S. Pat. No. 5,976,178, which is hereby incorporated by reference herein in its entirety. The above-described preferred porosity ofcoating 36 may help graft 30 to retain these coatings. - In the illustrative example of FIG. 1,
graft 30 has been used to form a connection between two sections ofbody organ tubing 32.Graft 30 may be used to connect portions of body organ tubing of any suitable shape. As defined herein, the term “body organ tubing” generally refers to elongated fluid-containing body organ tissues such as blood vessels and the like and to similar but less elongated body organ tissue structures such as portions of the heart wall.Body organ tubing 32 may be vascular tubing or any other type of body organ tubing. - In accordance with the present invention, connector structures such as
wire connectors 34 are used to attach the ends ofgraft 30 tobody organ tubing 32. Theillustrative connectors 34 of FIG. 1 are relatively short pieces of protruding wire that are welded to frame 38. - As shown in FIG. 2, portions of the
wire forming connectors 34 protrude on both sides of thebody organ tubing 32 to whichgraft 30 is attached. In particular,connector wires 40 protrude on one side of body organ tubing wall 42 (inside tubing 32) andconnector wires 44 protrude on the other side of body organ tubing wall 42 (outside tubing 32). This arrangement holdsgraft 30 firmly in place at the attachment site. -
Graft 30 is depicted as a bare metal mesh in FIG. 2 and many of the other FIGS. to show the details of construction of the connector structures. However,graft 30 preferably has a coating such ascoating 36 of FIG. 1. - As shown in FIG. 2,
wires connector structure 34 are preferably the bent ends of a single piece of wire. If desired, however,connector wires -
Wires wire 40 may be approximately 0.1 inches in length andwire 44 may be approximately 0.125 inches in length.Connectors 34 may be formed from 0.005-0.010 inch diameter round nitinol wire. These dimensions are merely illustrative. Wire of any suitable length and diameter may be used. If desired, the wire inconnectors 34 may be coated with a polymeric coating such as polytetrafluoroethylene (PTFE), to reduce abrasion ofbody organ tubing 32. - As shown in FIG. 3,
connectors 34 are formed around the entire periphery ofend 46 ofgraft 30. The number ofconnectors 34 that are used depends on the type of graft connection being formed, the difficulty and expense of providingadditional connectors 34, and the particular type ofconnectors 34 that are used. Althoughconnectors 34 are shown at the end of a portion of agraft 30 in FIGS. 1-3,connectors 34 may be placed at an intermediate location along the length ofgraft 30 if desired. Whenconnectors 34 are used to attachgraft 30 to body organ tubing, a portion of the body organ tubing is engaged ingap 33 byconnectors 34. -
Connectors 34 may be attached to graft 30 using any suitable mounting technique. For example, eachconnector structure 34 may be interwoven with the pattern ofmesh 38 and welded at pic points orwire intersections 48, as shown in FIG. 4a. In the illustrative interweaving pattern shown in FIG. 4a, the wire ofconnector 34 is first placed under the wires at awire intersection 48 offrame 38, then over anadjacent wire intersection 48, then under the nextadjacent wire intersection 48, then over the nextadjacent wire intersection 48. - Another illustrative interweaving pattern and mounting technique is shown in FIG. 4b. In FIG. 4b, each
connector 34 is glued to frame 38 at awire intersection 48. The wire ofconnector 34 is first placed under awire intersection 48, then under anadjacent wire intersection 48, then over the nextadjacent wire intersection 48, then over thenext wire intersection 48. Any suitable number of interweaving points and attachment points may be used. The number of times the wire ofconnector 34 is interwoven with the wire offrame 38 is partly determined by the pic count of frame 38 (i.e., the number of wire intersection points in the mesh offrame 38 per unit length along a straight axial line). The wire of eachconnector 34 is attached to frame 38 sufficiently often to ensure thatconnectors 34 are firmly attached to graft 30. Only a few interweaving and attachment points are shown in FIGS. 4a and 4 b to avoid overcomplicating the drawings. - As shown in FIG. 5,
connectors 34 may be attached (e.g., welded, glued, or otherwise suitably fastened) at attachment points 50 that do not coincide withwire intersections 48. - FIG. 5 also shows how the ends of
wires connector 34 may havehooks 52 that permitconnectors 34 to grip body organ tubing 32 (FIG. 1). By grippingbody organ tubing 32, hooks 52 facilitate the formation of a firm connection betweengraft 30 andbody organ tubing 32. -
Hooks 52 may be formed by bending the ends ofconnectors 34, by attaching separate hook members or by any other suitable technique. A hook 52 a formed by bending the end of aconnector 34 is shown in FIG. 6a. Ahook 52 b formed by attaching a length of wire to the end of aconnector 34 is shown in FIG. 6b. FIG. 6c shows ahook 52 c formed by attaching a triangular point to the end of aconnector 34. Any portion of a connector that should penetrate body tissue may be barbed so that the connector resists removal from tissue that it has penetrated. - In order to reduce tissue abrasion due to the wires of
connectors 34 rubbing against body organ tubing 32 (FIG. 1), at least the ends of thewires connectors 34 can be flattened rather than being perfectly round, as shown in FIG. 7a. If initially round,wires 40 and 44 (shown aswire 40/44 in FIG. 7a) may be flattened at their ends using any suitable technique. - As shown in FIG. 7b, flattened
wire 40/44 ofconnector 34 may be provided with ahook 52 d by bending the tip ofwire 40/44. - As shown in FIG. 8,
wires connectors 34 may be provided with webs of elastic material (e.g., silicone), such aswebs Webs wires graft 30 to thebody organ tubing 32 engaged ingap 33. - If desired,
connectors 34 may be formed from wire loops, such aswire loops Wire loops graft 30, as illustrated byloop 58 a. Alternatively,wire loops frame 38 is formed from a braided wire having, e.g., 64 strands, particularly suitable configurations for the connector structures ofgraft 30 may have 32, 16, 8, or 4loops graft 30 of FIG. 9 is connected to body organ tubing, a portion of body organ tubing is engaged ingap 33. - One suitable technique for installing a
graft 30 withconnectors 34 is shown in FIGS. 10a, 10 b, and loc. Prior to installation,graft 30 is loaded intosheath 68, thereby radially compressingwires graft 30 may be delivered to an installation site in a patient intraluminally. At the installation site,graft 30 is inserted into ahole 64 that has been formed in bodyorgan tubing wall 66, as shown in FIG. 10a. During insertion,sheath 68 holdswires connectors 34 radially inward and out of the way, so thatgraft 30 may be advanced throughhole 64 indirection 70. - As shown in FIG. 10b, once the distal end of
graft 30 is advanced throughhole 64 in bodyorgan tubing wall 66,sheath 68 can be drawn backward indirection 72. Drawingsheath 68backward releases wires 40, which assume their normal configuration by radially expanding as shown byarrows 74. - As shown in FIG. 10c,
sheath 68 is then drawn further backward indirection 72, untilwires 44 are released.Wires 44 then assume their normal configuration by radially expanding as shown byarrows 76. Oncewires graft 30 is held in place.Sheath 68 can therefore be removed. - If the other end of
graft 30 hasconnectors 34, the same attachment process may be performed at that end ofgraft 30 by inserting thepreloaded sheath 68 through another hole in the body organ tubing and removingsheath 68 through that hole (rather than movingsheath 68 away from that hole as shown in FIGS. - Another aspect of the invention is shown in FIGS. 11 and 12. As shown in FIG. 11,
graft 30 a may be provided withconnectors 34 a havingcurved wires 40 a and 44 a.Wires 40 a and 44 a are curved to varying degrees to match the curvatures encountered in making a graft connection with a tubular portion ofbody organ tubing 32 a. The end view of FIG. 11 shows howwires 40 a and 44 a of theconnectors 34 a that run along the curved portion of tubularbody organ tubing 32 a are highly curved. The side view of FIG. 12 shows howwires 40 a and 44 a of theconnectors 34 a that run along the interior and exterior surfaces of tubularbody organ tubing 32 a parallel to the longitudinal axis of tubularbody organ tubing 32 a are not curved.Other connectors 34 a that lie in planes not shown in FIGS. 11 and 12 preferably havewires 40 a and 44 a that are less curved than thewires 40 a and 44 a of FIG. 11 and that are more curved than thewires 40 a and 44 a of FIG. 12.Body organ tubing 32 a is engaged in the gap 33 a betweenwires 40 a and 44 a. - As shown in FIGS. 13 and 14,
graft 30 b may useconnectors 34 b withwires 40 b that extend sufficiently into the interior of tubularbody organ tubing 32 b that wires like wires 44 a of FIG. 11 are not required on the exterior surface ofbody organ tubing 32 b. In particular, becausewires 40 b run down along the interior surface of tubularbody organ tubing 32 past bisectingplane 78, a single set ofwires 40 b can holdgraft 30 b in place. The end view of FIG. 13 shows howwires 40 b that run along the curved portion of tubularbody organ tubing 32 b are highly curved. The side view of FIG. 14 shows howwires 40 b of theconnectors 34 b that run along the interior surface of tubularbody organ tubing 32 b in the axial direction are not curved.Other connectors 34 b that lie in planes not shown in FIGS. 13 and 14 may havewires 40 b that are less curved than thewires 40 b of FIG. 13 and that are more curved than thewires 40 b of FIG. 14 if desired. - Another connector arrangement is shown in FIGS. 15 and 16. As shown in FIG. 15,
graft 30 c may useconnectors 34 c having somewires 40 c that extend completely around the interior of tubularbody organ tubing 32 c, so that wires such as wires 44 a of FIG. 11 are not required on the exterior surface ofbody organ tubing 32 c. In particular,wires 40 c in the plane of the end view of FIG. 15 run completely around the interior surface of tubularbody organ tubing 32 c, so that a single set ofwires 40 c holdsgraft 30 c in place. The side view of FIG. 16 shows howwires 40 c of theconnectors 34 c that run along the interior surface of tubularbody organ tubing 32 c parallel to the longitudinal axis of tubularbody organ tubing 32 c are not curved.Other connectors 34 c that lie in planes not shown in FIGS. 15 and 16 may be less curved than theconnectors 34 c of FIG. 15 and more curved than theconnectors 34 c of FIG. 16. - The
connectors - Another type of wire connector structure that may be used is shown in FIG. 17a. The
wires 79 ofwire connector 80 are preferably integrally formed from a portion offrame 38 ofgraft 30.Wire connector 80 has an upperannular portion 82 and a lowerannular portion 84.Portions wires connectors 34 of FIG. 2.Graft 30 is connected to body organ tubing by engaging a portion of body organ tubing ingap 33 betweenportions - One suitable approach for fabricating connector structures such as
wire connector 80 is to formframe 38 over a mandrel and then to heattreat frame 38 in a furnace. This technique causes heat sensitive metals such as nitinol to retain the shape of the mandrel after the heat treatment has been completed and theframe 38 has been removed from the mandrel. Similar deformation and heat treatment steps can be used to formconnectors 34 of FIGS. 1-16. - If desired, reinforcing
wires 86 may be provided to line the inner surface ofconnector structure 80 as shown in FIG. 17b. Reinforcingwires 86 may be attached to frame 38 by any suitable attachment technique, such as by welding or gluing. - One suitable technique for installing a
graft 30 with aconnector 80 is shown in FIGS. 18a and 18 b. As shown in FIG. 18a,graft 30 is inserted into ahole 88 in bodyorgan tubing wall 90 usingsheath 92. Before insertion,graft 30 is preloaded intosheath 92, thereby holdingportions connector 80 radially inward and out of the way, so thatgraft 30 may be inserted throughhole 88. To insertgraft 30 inhole 88 of bodyorgan tubing wall 90,sheath 92 andgraft 30 are advanced indirection 94. - As shown in FIG. 18b, once the distal end of
graft 30 is advanced throughhole 88 in bodyorgan tubing wall 90,sheath 92 can be drawn backward indirection 96. Drawingsheath 92backward releases portions wire connector 80, so thatconnector 80 assumes its normal radially-expanded configuration and holdsgraft 30 in place.Sheath 92 can therefore be removed. - If the other end of
graft 30 has aconnector 80, the same attachment process may be performed at that end ofgraft 30 by inserting thepreloaded sheath 92 through a hole in the body organ tubing near that end and removingsheath 92 through that hole (rather than movingsheath 92 away from the hole as shown in FIGS. 18a and 18 b). - It is sometimes desirable to make connections between a graft and a portion of body organ tubing at a non-right angle, sometimes referred to herein as an oblique angle. The wire and frame-based connectors of the present invention are suitable for forming such connections.
- A typical right-angle connection between a
graft 30 and a portion ofbody organ tubing 32 is shown in FIG. 19a. As shown in FIG. 19b, such a right-angle connection creates acircular hole 98 inbody organ tubing 32. - An oblique-angle connection between
graft 30 and a portion ofbody organ tubing 32 is shown in FIG. 20a. Making an oblique-angle connection typically forms ahole 100 inbody organ tubing 32 that has a larger perimeter than thecircular hole 98 of FIG. 19b. The large perimeter ofhole 100 provides a larger contact area over which to form a firm connection betweengraft 30 andbody organ tubing 32. In addition, during some installation procedures it may not be convenient or practical to use a right-angle arrangement. - Any of
connectors graft 30 and a portion ofbody organ tubing 32. FIG. 21 shows how the obliquely-angleddistal tip 102 ofgraft 30 may haveconnectors 34 formed fromwires wires 44 grip the outer surface ofbody organ tubing 32, as shown in FIG. 22. Wires 40 (not shown in FIG. 22) grip the corresponding inner surface of thebody organ tubing 32 of FIG. 22. - The oblique-angle connection between
graft 30 andbody organ tubing 32 of FIG. 22 usesconnectors 34 formed fromwires sheath 68 of FIG. 10 andsheath 92 of FIG. 18a preferably have obliquely-angled ends. -
Wire connectors connectors 34 of FIG. 2 may be attached tosuitable ring structures 104, as shown in FIG. 23.Ring structures 104, which are preferably formed from a suitable elastomeric material, may be attached to a length ofnatural graft 106 bysutures 108. The resulting natural graft with artificial connectors may be used whenever a natural graft is appropriate but the ease of installation provided byconnectors 34 is desired. Similar ring-like standalone structures may be provided using the webbed connector arrangement of FIG. 8, the looped connector arrangement of FIG. 9, the curved connector wire arrangements of FIGS. 11-16, or the integral frame connector arrangement of FIGS. 17a and 17 b. - It will be understood that the foregoing is only illustrative of the principles of the invention, and that various modifications can be made by those skilled in the art without departing from the scope and spirit of the invention.
Claims (9)
1. A method of forming spike tips of an anastomotic connector, into hooks for engaging blood vessels, comprising:
providing an anastomosis connector having a plurality of straight spikes having tips;
first bending said tips at a first angle, using a first mandrel; and
second bending a furtherly distal portion of said tips using a second mandrel, to form a hook shape of said tips.
2. A method according to claim 1 , comprising mounting a graft on said spikes of said connector prior to said first bending.
3. A method of heat-treating an anastomosis connector, comprising:
fitting a cut connector into a mold;
fixing said mold to bend both forward and backwards spikes of said connector into a desired configuration; and
heat-treating said fixed connector, thereby training it to said configuration.
4. A connector adapter to be distorted for oblique connections, comprising:
a plurality of interconnected segments, at least some of said segments including a forward spike or a backward spike; and
a plurality of distortable portions defined between said segments, wherein said portions are adapted to support a distortion from a straight anastomosis to an oblique anastomosis.
5. A connector according to claim 4 , wherein said distortable portions comprise at least one ring.
6. A connector according to claim 4 , wherein said distortable portions are designated in a ring that interconnects said segments.
7. A connector according to claim 4 , wherein said distortable portions are annealed.
8. A connector according to claim 4 , wherein said spikes are self extending.
9. A connector according to claim 4 , wherein said distortable portions are plastically deformable.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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US10/171,425 US20020151913A1 (en) | 1997-10-09 | 2002-06-12 | Wire connector structures for tubular grafts |
US10/817,675 US20040243154A1 (en) | 1997-10-09 | 2004-04-02 | Wire connector structures for tubular grafts |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/946,742 US6074416A (en) | 1997-10-09 | 1997-10-09 | Wire connector structures for tubular grafts |
US09/505,540 US6451048B1 (en) | 1997-10-09 | 2000-02-17 | Wire connector structures for tubular grafts |
US10/171,425 US20020151913A1 (en) | 1997-10-09 | 2002-06-12 | Wire connector structures for tubular grafts |
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US09/505,540 Continuation US6451048B1 (en) | 1997-10-09 | 2000-02-17 | Wire connector structures for tubular grafts |
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US10/817,675 Continuation US20040243154A1 (en) | 1997-10-09 | 2004-04-02 | Wire connector structures for tubular grafts |
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US09/505,540 Expired - Lifetime US6451048B1 (en) | 1997-10-09 | 2000-02-17 | Wire connector structures for tubular grafts |
US10/171,425 Abandoned US20020151913A1 (en) | 1997-10-09 | 2002-06-12 | Wire connector structures for tubular grafts |
US10/817,675 Abandoned US20040243154A1 (en) | 1997-10-09 | 2004-04-02 | Wire connector structures for tubular grafts |
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US08/946,742 Expired - Lifetime US6074416A (en) | 1997-10-09 | 1997-10-09 | Wire connector structures for tubular grafts |
US09/505,540 Expired - Lifetime US6451048B1 (en) | 1997-10-09 | 2000-02-17 | Wire connector structures for tubular grafts |
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US10/817,675 Abandoned US20040243154A1 (en) | 1997-10-09 | 2004-04-02 | Wire connector structures for tubular grafts |
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US (4) | US6074416A (en) |
AU (1) | AU9031898A (en) |
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Also Published As
Publication number | Publication date |
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AU9031898A (en) | 1999-05-03 |
WO1999018887A1 (en) | 1999-04-22 |
US6074416A (en) | 2000-06-13 |
US6451048B1 (en) | 2002-09-17 |
US20040243154A1 (en) | 2004-12-02 |
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