US20030195530A1 - Septal defect occluder - Google Patents

Septal defect occluder Download PDF

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Publication number
US20030195530A1
US20030195530A1 US10/419,412 US41941203A US2003195530A1 US 20030195530 A1 US20030195530 A1 US 20030195530A1 US 41941203 A US41941203 A US 41941203A US 2003195530 A1 US2003195530 A1 US 2003195530A1
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United States
Prior art keywords
occluder
fabric
cambered
fabric support
support structures
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Abandoned
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US10/419,412
Inventor
Gary Thill
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Ev3 Inc
KMC Enterprises Inc
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Microvena Corp
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Publication date
Priority claimed from US09/558,717 external-priority patent/US6214029B1/en
Application filed by Microvena Corp filed Critical Microvena Corp
Priority to US10/419,412 priority Critical patent/US20030195530A1/en
Assigned to EV3 INC. reassignment EV3 INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: MICROVENA CORPORATION
Assigned to KMC ENTERPRISES INC. reassignment KMC ENTERPRISES INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GRUBBA, BILL
Publication of US20030195530A1 publication Critical patent/US20030195530A1/en
Assigned to EV3 ENDOVASCULAR, INC. reassignment EV3 ENDOVASCULAR, INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: EV3 INC.
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/076Surgical instruments, devices or methods, e.g. tourniquets for removing surgical staples or wound clamps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac
    • A61B2017/00247Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00592Elastic or resilient implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00597Implements comprising a membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00623Introducing or retrieving devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00392Transmyocardial revascularisation

Definitions

  • the present invention generally relates to devices for occluding septal defects or shunts in the heart or the vascular system, and particularly provides a low profile septal defect conforming device reversibly deliverable via catheter to a septal defect site.
  • tissue defect generally refers to a perforation or other type hole (i.e., a defect) which passes through a thin wall of muscle or other tissue (i.e., a septum) which divides or separates “areas” within the body.
  • a perforation or other type hole i.e., a defect
  • tissue i.e., a septum
  • Such defects can occur, either congenitally or by acquisition, between chambers of the heart (i.e., atrium or ventricle) or the great vessels (interatrial and interventricular septal defects or patent ductus arteriosus and aortico-pulmonary window respectively), causing shunting of blood through the opening.
  • Atrial septal defects were initially corrected by open heart surgery which required the surgeon to open the chest of a patient and bypass the heart temporarily (e.g., by means of a cardiopulmonary bypass and moderate hypothermia) The surgeon would then physically cut into the heart and suture small defects closed. In the case of larger defects, a patch of a biologically compatible material would be sewn onto the septum to cover (i.e., “patch”) the defect.
  • One such closure device includes a pair of complex mechanical umbrellas, each having a plurality of arms extending radially from a central hub.
  • the hubs of the two umbrellas are mechanically connected to one another and each umbrella includes a fabric covering over the arms, much like a common umbrella.
  • the ends of each arm are provided with barbs which are anchored into the septum to hold the occluder in place.
  • the complex umbrellas prove rather difficult to unfold after passage through a catheter, requiring an array of cables to deploy the arms. This makes proper placement of the device difficult, and the barbs on the arms prevent retraction or repositioning of the device once it is in place.
  • Use of this device has been limited to adult patients because the device requires a large catheter, such as about 23 French (7.3 mm), for delivery.
  • Rashkind proposed a single-umbrella closure device capable of delivery through a 5 mm system which permitted use in children weighing at least about 20 kg. Similar to the King device, this umbrella utilizes barbed hooks on the ends of umbrella arms to ensure attachment to the septum, with the single umbrella being placed on the left side of the atrial septal defect. The barbs prevent disengagement of the device, and poorly centered or seated devices requiring open heart surgery for correction are common.
  • Sideris in U.S. Pat. No. 4,917,089, proposed an occlusion device which combines a single umbrella with a separate anchoring device.
  • Sideris' invention utilizes an umbrella with a plurality of radially extending arms.
  • a string connects the arms of this umbrella to a generally rhomboidally shaped anchor which includes an internal wire skeleton and a central, rhomboidally shaped piece of rubber.
  • the string attached to the struts of the umbrella is affixed to the central rubber element of the anchor.
  • the anchor is placed on the opposite side of the septum from the umbrella, and the length of the string limits movement of the occlusion device with respect to the septum.
  • This style of occluder is difficult to deploy, and its overall bulkiness in the heart causes potential clot emboli due to protrusion into the atrial cavities.
  • Kotula et al. U.S. Pat. No. 5,725,552 provides a collapsible device comprising a heat-set woven metal fabric configured as a bell, hourglass, etc. for occluding an abnormal opening in a body organ.
  • the device of Kotula et al. does not adequately “fill” the defect nor fit flat against, or readily conform to, the structures within the heart, thereby increasing the embolization potential with the use of such device.
  • Das U.S. Pat. No. 5,334,217, teaches a non-retrievable occluder having paired disks, each of which comprises a membrane, and an elastically deformable frame carried about the periphery of each membrane. The disks are joined only at central portions of each membrane, thereby defining a conjoint disk.
  • the Das device is intended to be self-centering within the defect. Since the ability to achieve defect conformity is limited due to the defined conjoint disk structure, residual shunting can occur. Furthermore, with such a device, the conjoint disk cannot uniformly apply and distribute a force to the “second” disk (e.g., as when the second disk follows the first disk into the catheter for purposes of retrieval. As a result, the occluder is caused to contort, resulting in non-symmetrical collapse, and the problems associated therewith.
  • the present invention is a septal defect occluder which has first and second occluder panels.
  • Each occluder panel includes a fabric support structure and fabric suspended from a perimeter thereof.
  • the occluder panels are conjoined at a plurality of points which are located within an area bounded by the perimeter of each fabric support structure, as well as on the fabric, to thereby form a defect conforming region for the occluder.
  • a septal defect occluder having first and second occluder panels.
  • Each occluder panel includes a cambered fabric support structure and fabric suspended from a perimeter thereof.
  • the occluder panels are arranged in cooperative cambered opposition such that the perimeters of the cambered fabric support structures impart a clamping force upon tissue adjacent a tissue defect interposed there between when the occluder is deployed for tissue defect occlusion.
  • FIG. 1 is a side elevational view of the septal defect occluder of the present invention deployed in a septal defect;
  • FIG. 2 is an end view of an occluder panel of the septal defect occluder of the present invention, particularly illustrating a center fabric attachment point;
  • FIG. 3 is an end view of the frame members of the device of the subject invention having two pairs of opposing inward eyelets;
  • FIG. 4 depicts a fabric sheet suitable for use with the invention
  • FIG. 5 is an end view of two frame members of FIG. 3 arranged to form a fabric support structure having both internal and perimeter eyelets;
  • FIG. 6 depicts a first occluder half, corresponding to the fabric support structure of FIG. 5, showing the relationship between the fabric sheet of FIG. 4 and the underlaying support structure;
  • FIG. 7 depicts a second occluder half, corresponding to the second fabric support structure of FIG. 5, showing the relationship between the fabric sheet of FIG. 4 and the underlaying support structure;
  • FIG. 8 is an overhead perspective view of an alternate occluder panel
  • FIG. 9 is an overhead perspective view of the underlaying cambered fabric support structure of the alternate occluder panel of FIG. 8;
  • FIG. 10 is an overhead perspective view of a frame member of the cambered fabric support structure being formed using a cambered winding fixture
  • FIG. 11 is a side view of the present invention being delivered within a catheter to a septal defect site
  • FIG. 12 is a side view of the present invention being initially deployed within the septal defect, the second occluder half having expanded to conform to a portion of the defect;
  • FIG. 13 is a side view of the present invention deployed within the septal defect while under the control of tension imparting means;
  • FIG. 14 is a side view of the present invention being initially retrieved into the catheter from the septal defect site, the first occluder half being collapsed for catheter entry; and,
  • FIG. 15 is a side view of the present invention on its way to complete retrieval into the catheter from the septal defect site.
  • a septal defect closure device 20 of the invention may be attached to the septum S (e.g., an atrial septum) to effectively conform to and block the defect, without protruding into atrial cavities and the like.
  • the closure device 20 becomes anchored to the septum and prevents the flow of blood through the atrial septum to the adjoining chambers of the heart. This will permit the heart to operate normally.
  • the extremely low profile closure device includes first and second occluder panels 30 , 60 .
  • Each panel 30 , 60 is generally round (e.g., circular, oval, elliptical etc.) so as to facilitate positioning, and minimizes chances of erosion and puncture.
  • Each panel 30 , 60 generally comprises a fabric support structure 32 , 62 and fabric 33 suspended from a perimeter 34 , 64 of the fabric support structures 32 , 62 .
  • the occluder panels 30 , 60 are conjoined at a plurality of discrete points, located or positioned within the bounds of each of the fabric support structures 32 , 62 (i.e., within an area bounded by each perimeter 34 , 64 of the support structures 32 , 62 ), as well as on the fabric 33 (which will be further explained with reference to FIGS. 2, 7 and 8 ).
  • a defect conforming region 80 for the occluder 20 is thereby formed.
  • the nature (i.e., structure, relationships there between and function) of the defect conforming region will be detailed herein below, particularly with reference to FIGS. 1, 2 and 9 - 14 . At this point it may be said that the region 80 expandingly conforms to substantially completely and thoroughly satisfy the perimeter of the defect geometry. This stabilizes panels 30 , 60 so that complete coverage of the defect from either direction is achieved. The defect is thereby occluded without distortion of the defect.
  • the fabric support structures 32 , 62 of the occluder are generally flexible and elastically deformable, and include perimeter and traversing segments 36 , 38 .
  • Resilient fabric 33 (FIG. 4) is suspended or otherwise affixed to the perimeter segments 36 of the fabric support structures 32 , 62 .
  • the perimeter segments 36 of the fabric support structures 32 , 62 extend substantially around the periphery 35 of the fabric 33 .
  • the fabric 33 may be formed of a thin, flexible material which can be folded and pulled taut without being damaged.
  • Elastic polymeric materials such as, for example, polyester knit, nylon, polypropylene, polytetrafluoroethylene (e.g., Teflon®), and expanded polytetrafluoroethylene (e.g., GoreTex®), as well as natural fabrics such as silk, are acceptable.
  • polytetrafluoroethylene e.g., Teflon®
  • expanded polytetrafluoroethylene e.g., GoreTex®
  • excess fabric can be provided.
  • an excess of fabric in the range typically, of about 30-35 percent, and up to 50 percent, is sufficient. This range is required for low stretch fabric that otherwise may prevent the support structure from collapsing in a manner suitable to get into the catheter.
  • the 20 denier polyester knit is advantageous in that it is of approximately 50% less bulk than known jersey style knit configurations which facilitates the use of smaller delivery catheters, and allows for the occluders to be retrieved into such catheters at forces that are not detrimental to either the catheter or the occluder (e.g., a 40 mm occluder may be pulled into a 12 French catheter using a reasonable peak force of about four pounds).
  • a further advantage is that two complete fabric “patches” may be incorporated, into the closure device (i.e., no need to remove material to reduce bulk), which thereby creates a device having a high reliability of successful closure.
  • the fabric 33 may be attached to their respective support structures 32 , 62 by any suitable means.
  • the fabric 33 may be directly attached to the support structures 32 , 62 by means of an adhesive or the like, or the periphery 35 of the fabric 33 may be wrapped about each of the support structures 32 , 62 and the peripheral edge attached to the rest of the fabric so as to essentially define a sleeve about each of the support structures 32 , 62 .
  • the sleeve may fit the support structure relatively loosely so that the structure may move within the sleeve with respect to the fabric.
  • the peripheral edge of the fabric may be affixed to the rest of the fabric sheet 33 in any suitable fashion such as by sewing.
  • the periphery of the fabric can be sewn to at least some portion of the perimeter segments 36 of the support structures 32 , 62 using polyester, non-adsorbable suture.
  • the fabric support members 32 , 62 of the occluder panels 30 , 60 are shown as being spaced from one another for purposes of the present explanation, but this is not the normal configuration (i.e., static condition) of the panels.
  • the fabric support structures of the device take a generally planar form, with the two fabric support structures 32 , 62 generally abutting against, or closely proximate, one another.
  • the occluder panels 30 , 60 are conjoined at a plurality of discrete points, the points being selected to effectively link each of the fabric support structures 32 , 62 together, as well as associate each sheet of fabric 33 carried thereby, so as to form the variably configurable defect conforming region 80 .
  • the resilient fabric 33 is not only inherently or indirectly positionable in response to the defect geometry, but also directly responsive vis-a-vis the conjoined support structures 32 , 62 .
  • the conjoined points within the fabric support structures 32 , 62 which responsively link the opposing structures, comprise loops formed in the traversing segments 38 thereof, these loops defining internal eyelets 40 for the structures 32 , 62 .
  • the internal eyelets 40 of each of the structures 32 , 62 are shown as being joined by suture (e.g., polyester, non-absorbable or other suitable material), and to some extent delimit the defect conforming region 80 , and serve to center the occluder 20 within the defect.
  • the remaining points of conjointment comprise the union, at a single point, of the fabric of each of the fabric support structures so as to define a generally central fabric attachment point 42 . It is important that fabric 33 of each support structure 32 , 62 be limitingly controlled via the union, however it is equally important that the fabric 33 remain substantially suspended for expansion during deployment, preferably exclusively about or by its periphery 35 .
  • the center attachment point 42 of the occluder 20 is preferably but not exclusively configured as a sutured cross stitch positioned in the center of the fabric 33 .
  • Other attachment configurations or geometries are contemplated, to the extent that the center attachment point 42 maintains its functionality, namely that of control of the peripherally supported fabric, and generally contributing to a centering function for the occluder.
  • the internal eyelets 40 are symmetrically oriented about the center fabric attachment point 42 .
  • the perimeter segments 36 of at least one (i.e., structure 62 ) of the fabric support structures 32 , 62 include loops formed therein, thereby defining perimeter eyelets 44 for that particular support structure 62 .
  • the perimeter eyelets 44 cooperate with urging means 46 carried by and or through a catheter 47 so as to aid in the symmetrical collapse of each of the fabric support structures 32 , 62 , and the occluder panels 30 , 60 thereby, during reversible retrieval of the device 20 into the catheter 47 .
  • the perimeter eyelets 44 associated with the “catheter side” occluder panel 60 transmit and distribute deployment and retrieval forces imparted thereupon through the defect conforming region 80 and to the other occluder panel 30 .
  • the unique configuration of the fabric support structure components, and the relationships there between provide numerous advantages (for example: symmetrical collapse of the occluder, less peak force for retrieval into a catheter for deployment, and heretofore unsurpassed sealing of narrow slit defects without the distorting effects typically associated with fixed geometry conjoint areas such as circumferential conjoint disks).
  • the fabric support structures comprise cooperating frames 50 , each of which preferably resembles a “bowtie,” as best seen in FIG. 3.
  • a more technical description for the frame geometry might be to characterize it as an octagon (i.e., a frame of eight legs or segments), particularly an octagon having a concave, rather than convex, “top” and “bottom” (i.e., ceiling and floor).
  • the frames resemble elongated hexagons whose long sides are “pinched” towards each other.
  • the frames 50 may be generally characterized as having maximum and minimum dimensions and corresponding axes of maximum and minimum dimension 52 , 54 .
  • the above frame description is intended to be illustrative, not limiting, with alternating frame geometries satisfying the general characterization being possible.
  • the internal eyelets 40 of the fabric support structures 32 , 62 are formed in each of the frames 50 along the axis of minimum dimension 54 (FIG. 3), as illustrated.
  • the resilient internal eyelets 40 are generally disposed between adjacent ends of two legs or frame segments 51 , one end of the eyelet being attached to each leg 51 .
  • the internal eyelets 40 are shown as laying generally in the same plane as the legs 51 and may extend generally outwardly of the periphery of each of the support structures 32 , 62 , or may preferably extend inwardly of the periphery of the structures as shown in the figures.
  • each of the frames 50 , 50 A of the fabric support structures 32 , 62 may be cambered about their minimum dimension (i.e., the internal eyelets 40 do not lay in the same plane as the legs 51 , or more specifically, the internal eyelets 40 and perimeter eyelets 44 are not coplanar) so as to, among other things, provide an occluder capable of exerting a clamping force at the perimeter edge of the tissue defect when deployed.
  • the eyelets are desirably formed to function as spring hinges. This will serve to ensure that the occluder panels 30 , 60 , particularly the catheter side panel 60 , elastically return substantially to a plane-defining configuration even after they have been collapsed and delivered through a catheter.
  • Frames 50 of the device have internal eyelets 40 , as previously explained.
  • the internal eyelets 40 of one fabric support structure i.e., 32
  • mate i.e., align or register
  • those of the other support structure i.e., 62
  • the perimeter eyelets 44 of fabric support structure 62 are formed in its frames 50 A along the axis of maximum dimension 54 (FIG. 3).
  • the perimeter eyelets 44 cooperatively engage urging means 46 so as to enable remote manipulation of the occluder 20 during retrieval.
  • Each fabric support structure 32 , 62 comprises perpendicularly overlaying frames, the axis of maximum dimension 52 of one frame 50 or 50 A substantially aligning with the axis of minimum dimension 54 of the other frame (FIG. 5).
  • the somewhat oversized fabric 33 is shown in FIG. 6 underlaying the cooperating frames, the periphery thereof being sewn or otherwise affixed to those portions of the frames, which when configured as shown in FIG. 5, form a perimeter 34 , 64 for each of the fabric support structures 32 , 62 .
  • the preferred fabric 33 contributes to an occluder 20 that has complete opposing fabric patches suspended by the fabric support structures 32 , 62 , which in turn include a frame geometry and arrangement that generally reduce deployment and retrieval forces. In return, fabric and stitch wear and tear and frame “break through” (i.e., separation of the perimeter segments 36 from the fabric 33 upon expansion of the occluders 30 , 60 ) are minimized.
  • Each frame 50 is preferably formed of a single elongate strand of wire W.
  • each of the legs 51 may simply comprise a length of the wire, and the wire may be bent through greater than 360 degrees to define adjacent legs 51 and to form the loops or eyelets 40 , 44 .
  • the ends of the wire may be attached to each other in any secure fashion, such as by means of a weldment or a suitable biocompatible cementitious material.
  • the frames 50 should be formed of a flexible, elastically deformable material such as a metal, and the wire comprising the frame is formed of a superelastic material.
  • a superelastic material such as a near-stoichiometric nickel/titanium alloy, commonly referred to as Nitinol or NiTi.
  • Such superelastic materials may be elastically deformed to a much greater extent than most other materials, yet substantially fully recover their original shape when released. This permits the frame to be deformed sufficiently for insertion into, and passage through, a small-diameter catheter yet automatically elastically return to its initial shape upon exiting the catheter.
  • the frames are preferably manufactured with nitinol wire that can be wound around the pins of a forming die and subjected to heat treatment.
  • Each device consists of four frames, two frames for each support structure. More particularly, each support structure 32 , 62 comprises matchingly paired frame styles (i.e., as shown in FIGS. 6 and 7, occluder panel 30 has a pair of frames 50 whereas occluder panel 60 has a pair of frames 50 A). All eyelets 40 , 44 can be made having generally a 0.030 inch inside diameter, and, as previously noted, be inward facing (i.e., directed toward the center fabric attachment point 42 ). The wire ends of each frame can be connected with a titanium hypo tube using a compression crimp.
  • the titanium is more ductile than the nitinol, providing a reliable grip with excellent corrosion resistance.
  • the preferred shape of the frame may be cut out from a sheet of such superelastic material as a single block, by chemical etching, punching with a suitable punch and die, or any other appropriate forming method.
  • the frame may be provided with a radiopaque coating, such as gold or platinum.
  • the wire W may be plated with a thin layer of gold or platinum.
  • a helically wound length of a thin radiopaque wire (not shown) is placed over the wire W; such core/coil structures are well known in the art.
  • radiopaque marking bands (not shown), which are commercially available, may be employed. By placing one such band on each leg of the frame, a physician can remotely visualize the frame as a plurality of small bands; when the bands are appropriately spaced from one another on a monitor, the physician knows that the frame is properly deployed.
  • each occluder panel 30 includes a cambered fabric support structure 37 which otherwise conforms with/to the fabric support structure previously disclosed (i.e., the fabric support structure 37 of FIG. 8, and frame member 39 shown being formed in FIG. 10, each have the general end view appearance as the embodiment depicted in FIGS. 2 and 3 respectively, including eyelets which have been omitted from FIGS. 8 through 10 for the sake of clarity).
  • Each of the occluder panels 30 are arranged in cooperative cambered opposition such that the perimeters 41 of the cambered fabric support structures 37 impart a clamping force upon tissue adjacent a tissue defect interposed there between when the occluder is deployed for tissue defect occlusion. Furthermore, because the entire perimeter 35 of the fabric 33 is supported by the cambered fabric support structure 37 , and because the occluder panels 30 are urged together at the perimeter edge of the defect due to their arrangement in biased opposition, intimate contact of the occluder with the tissue is assured which is advantageous in supporting endothelial tissue growth during the final stages of healing.
  • the aforementioned occluder panel design substantially improves performance in the area of the occluder “go flat” characteristic.
  • “go flat” characteristic i.e., “flatness”
  • occluders particularly larger devices (i.e., in excess of about 28 mm across), sometimes have difficulty returning to a “flat” shape (i.e., less than about 2 mm separation between occluder panels or halves) post deployment from a catheter.
  • each of the frame members or elements 39 of each of the fabric support structures 37 are cambered about their minimum dimension 43 (i.e., the internal eyelets do not lay in the same plane as the legs, or more specifically, the internal eyelets and perimeter eyelets are not coplanar). Said another way, each frame element 39 has a camber axis 45 which is in substantial conformity with the axis of minimum dimension 43 , compare FIGS. 3 and 10.
  • Each cambered fabric support structure 37 comprises perpendicularly overlaying frames 39 , the axis of maximum dimension 48 of one frame substantially aligning with the axis of minimum dimension 43 and camber 45 of the other frame. Furthermore, as best seen in FIGS.
  • the cambered frame members 39 are arranged in forming the cambered fabric support structure 49 such that a support structure apex 49 is formed, the apex 49 being defined as the intersection of camber axis 45 for the cooperating frame members 39 .
  • the somewhat oversized fabric 33 indicated by dashed line in FIG. 8 has a periphery 35 sewn or otherwise affixed, as the embodiment illustrated in FIGS. 2, 6, and 7 , to those portions of the frame elements 39 which form a perimeter 41 for each of the fabric support structures 37 .
  • the preferred fabric carried by the fabric support structures of the subject invention contributes to an occluder that has complete opposing fabric patches suspended by the cambered fabric support structures, which in turn yields a preloaded frame geometry and occluder panel arrangement that generally reduces deployment and retrieval forces while enhancing the stay flat characteristics of the device.
  • cambered frame members which comprise the cambered fabric support structures are manufactured much like the “planar” frames of FIG. 3, namely with nitinol wire that can be wound around the pins 53 of a forming die 55 and subjected to heat treatment, during the winding process, a biasing mandrel (not shown) is used in combination with the forming die 55 to form the cambered frame member 39 .
  • the forming die 55 itself may be contoured so as to produce a cambered frame as is depicted in FIG. 10.
  • the occluder panels are conjoined at a plurality of discrete points, the points being selected to effectively link each of the cambered fabric support structures together, as well as associate each sheet of fabric carried thereby, so as to form the variably configurable defect conforming region.
  • the resilient fabric is not only inherently or indirectly positionable in response to the defect geometry, but also directly responsive vis-a-vis the conjoined support structures.
  • the general closure device 20 of the invention i.e., those embodiments previously described
  • the first panel 60 i.e., catheter side occluder panel
  • the frames 50 or 50 A of the fabric support structures 32 , 62 are elastically biased toward the position shown in FIG. 2.
  • the defect conforming region 80 is positioned within, and expands so as to occlude the defect.
  • the support structures 32 , 62 are elastically biased toward their deployed configuration, they are biased generally toward one another and engage opposing sides of the septum about the defect. Since there are no compressive forces acting on the frames which might cause them to collapse, this serves to effectively hold the device in place and occlude the defect.
  • the device is further shown in FIGS. 14 and 15 being retrieved from a septal defect site, as might be required in the event of inadvertent initial placement, size mismatch, or otherwise.
  • the fabric sheets 33 are formed of a relatively porous material (FIG. 4). While this may seem to contradict the purpose of the device, blood will tend to coagulate on the latticework provided by the porous material. Blood flow across the defect is usually substantially blocked after minimal time passage. If so desired, the conjoint portion of the device (or the entire device) may be treated with a thrombogenic agent to speed this natural process or may be impregnated with a biocompatible polymeric compound or the like to make it relatively impervious to fluids.
  • the primary purpose of using a porous fabric is to accelerate the process of permanently anchoring the device in place.
  • the support structures hold the fabric tautly and in intimate contact with the surface of the septum S. This intimate contact between the septum and perimeter of the occluder permits ingrowth of collagen and fibrous tissue from the septum into the fabric. Over time, the membrane resting against the septum will become securely anchored to the septal wall and be covered by a layer of endothelial cells.
  • the instant closure device can be used to treat ventricular septal defects, patent ductus arteriosus, patent foramen ovale (PFO), or any other congenital or acquired orificial or tubular communications between vascular chambers or vessels.
  • PFO patent foramen ovale
  • the aggregate number of shares of stock which the Merging Company has authority to issue is 35,450,000 shares, which consist of 32,500,000 shares of Class A Common Stock, 200,000 shares of Class B Common Stock, 1,600,000 shares of Series A Convertible Preferred Stock, 150,000 shares of Series B Convertible Preferred Stock, 347,755 shares of Series C Convertible Preferred Stock and 652,245 shares of undesignated stock.
  • the par value of each share of capital stock of the Merging Company is 5.01.

Abstract

A septal defect occluder is provided having first and second occluder panels. Each occluder panel includes a fabric support structure and fabric suspended therefrom. The occluder panels are conjoined at a plurality of discrete points which are located within an area bounded by each perimeter of the fabric support structures, as well as on the fabric, to thereby form a defect conforming region for the occluder. In an alternate embodiment, each occluder panel includes a cambered fabric support structure and fabric suspended from a perimeter thereof, the occluder panels being arranged in cooperative cambered opposition such that the perimeters of the cambered fabric support structures impart a clamping force upon tissue adjacent a tissue defect interposed there between when the occluder is deployed for tissue defect occlusion.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation-in-part of co-pending application Ser. No. 09/558,717, filed Apr. 26, 2000, for SEPTAL DEFECT OCCLUDER.[0001]
  • TECHNICAL FIELD
  • The present invention generally relates to devices for occluding septal defects or shunts in the heart or the vascular system, and particularly provides a low profile septal defect conforming device reversibly deliverable via catheter to a septal defect site. [0002]
  • BACKGROUND OF INVENTION
  • The term “septal defect” generally refers to a perforation or other type hole (i.e., a defect) which passes through a thin wall of muscle or other tissue (i.e., a septum) which divides or separates “areas” within the body. Such defects can occur, either congenitally or by acquisition, between chambers of the heart (i.e., atrium or ventricle) or the great vessels (interatrial and interventricular septal defects or patent ductus arteriosus and aortico-pulmonary window respectively), causing shunting of blood through the opening. [0003]
  • In the case of the atrium, the presence of a significantly large septal defect can allow blood to shunt across the defect from the left atrium to the right atrium and hence on to the left ventricle, aorta and brain. If the defect is not closed, the risk of stroke is increased. [0004]
  • Shunting of blood from the right to the left side can also have negative consequences. This can lead to death due to cardiac failure or hemoptysis. [0005]
  • In patients with significant sized ventricular septal defects or patent ductus arteriosus, there is shunting of blood from the high pressure left ventricle or aorta, into the right side chambers and pulmonary arteries which normally have much lower pressures. The torrential increase in flow at a high pressure can lead to cardiac failure and death, apart from the serious long-term complication of high pulmonary pressures which can cause a reversal of the direction of the shunt. [0006]
  • Atrial septal defects were initially corrected by open heart surgery which required the surgeon to open the chest of a patient and bypass the heart temporarily (e.g., by means of a cardiopulmonary bypass and moderate hypothermia) The surgeon would then physically cut into the heart and suture small defects closed. In the case of larger defects, a patch of a biologically compatible material would be sewn onto the septum to cover (i.e., “patch”) the defect. [0007]
  • In order to avoid the morbidity, mortality and long recovery times associated with open heart surgery, a variety of transcatheter closure techniques have been attempted. In such techniques, an occluding device is delivered through a catheter to the septal defect site. Once the closure device is positioned adjacent the defect, it must be attached to the rest of the septum in a manner which permits it to effectively block the passage of blood through the defect. [0008]
  • One such closure device, as illustrated in U.S. Pat. No. 3,874,388 (King et al.), includes a pair of complex mechanical umbrellas, each having a plurality of arms extending radially from a central hub. The hubs of the two umbrellas are mechanically connected to one another and each umbrella includes a fabric covering over the arms, much like a common umbrella. The ends of each arm are provided with barbs which are anchored into the septum to hold the occluder in place. The complex umbrellas prove rather difficult to unfold after passage through a catheter, requiring an array of cables to deploy the arms. This makes proper placement of the device difficult, and the barbs on the arms prevent retraction or repositioning of the device once it is in place. Use of this device has been limited to adult patients because the device requires a large catheter, such as about 23 French (7.3 mm), for delivery. [0009]
  • Rashkind proposed a single-umbrella closure device capable of delivery through a 5 mm system which permitted use in children weighing at least about 20 kg. Similar to the King device, this umbrella utilizes barbed hooks on the ends of umbrella arms to ensure attachment to the septum, with the single umbrella being placed on the left side of the atrial septal defect. The barbs prevent disengagement of the device, and poorly centered or seated devices requiring open heart surgery for correction are common. [0010]
  • Due to the low success rate of previous devices, a “modified double-umbrella Rashkind occluder” in which the arms of the device are hinged to permit them to fold back against themselves was developed. A more compact collapsed condition and a less intrusive delivery as by an 11 French (3.7 mm) catheter were thereby facilitated. Furthermore, such a “clamshell” occluder did not include barbs at the end of the radial arms of the umbrella, allowing it to be readjusted and retrieved. Typically, this could be accomplished only once, and without subsequent redeployment due to damage or destruction of the device. Although arguably an improvement over heretofore known devices, such a device generally requires a complex loading jig for deployment and remains susceptible to moderately high shunting. [0011]
  • Sideris, in U.S. Pat. No. 4,917,089, proposed an occlusion device which combines a single umbrella with a separate anchoring device. Like the previous defect occlusion devices, Sideris' invention utilizes an umbrella with a plurality of radially extending arms. A string connects the arms of this umbrella to a generally rhomboidally shaped anchor which includes an internal wire skeleton and a central, rhomboidally shaped piece of rubber. The string attached to the struts of the umbrella is affixed to the central rubber element of the anchor. The anchor is placed on the opposite side of the septum from the umbrella, and the length of the string limits movement of the occlusion device with respect to the septum. This style of occluder is difficult to deploy, and its overall bulkiness in the heart causes potential clot emboli due to protrusion into the atrial cavities. [0012]
  • Kotula et al., U.S. Pat. No. 5,725,552, provides a collapsible device comprising a heat-set woven metal fabric configured as a bell, hourglass, etc. for occluding an abnormal opening in a body organ. The device of Kotula et al. does not adequately “fill” the defect nor fit flat against, or readily conform to, the structures within the heart, thereby increasing the embolization potential with the use of such device. [0013]
  • Das, U.S. Pat. No. 5,334,217, teaches a non-retrievable occluder having paired disks, each of which comprises a membrane, and an elastically deformable frame carried about the periphery of each membrane. The disks are joined only at central portions of each membrane, thereby defining a conjoint disk. The Das device is intended to be self-centering within the defect. Since the ability to achieve defect conformity is limited due to the defined conjoint disk structure, residual shunting can occur. Furthermore, with such a device, the conjoint disk cannot uniformly apply and distribute a force to the “second” disk (e.g., as when the second disk follows the first disk into the catheter for purposes of retrieval. As a result, the occluder is caused to contort, resulting in non-symmetrical collapse, and the problems associated therewith. [0014]
  • All of the prior art devices described above suffer shortcomings. First, most of these systems (i.e., the occluder and delivery means) are mechanically complex and require a great deal of remote manipulation for deployment or retrieval, if the device is retrievable. This extensive remote manipulation, such as by applying tension to one or more cables in order to deploy the arms of an umbrella or to anchor the device in place, not only increases the difficulty of the procedure, but tends to increase the likelihood that the device will be improperly deployed. This can necessitate retrieval or repositioning so as to effectively occlude the defect in order to minimize the risk of embolization. [0015]
  • Second, all of these devices, except for Kotula and Das, essentially teach two separate members joined to each other at a single interface. With such device, when the left atrial member is opened, the central point tends to ride to the lower margin of the defect. Proper centering of the device is quite difficult, and when a self centering device as disclosed by Das is employed, it is at the cost of defect conformity. [0016]
  • Third, heretofore many known devices have a geometry which tends to prevent the occluder from remaining flat against, or within, the defect once deployed from a catheter, which is in and of itself problematic, and which is likely to deform the tissue adjacent the tissue defect. A further limitation associated with such devices is that intimate contact between the perimeter of the occluder and the tissue adjacent the tissue defect (e.g., a septal wall), a prerequisite for the formation of a smooth endothelial growth layer in the final stages of healing, is difficult to obtain using heretofore known occluders. [0017]
  • Fourth, heretofore many known devices possess retrieval limitations, while others are fully not retrievable. [0018]
  • It is desirable, therefore, to provide a simple, collapsible compact closure device which may be delivered through a catheter. It is also highly advantageous to have such a device which can be readily reversibly deployed and retrieved with a minimum of remote manipulation and applied force. Further, a device which is self-centering and self-occluding, particularly one that possesses a defect conforming variable geometry to fill slit-like defects such as a patent foramen ovale, and one that can be released while still being tethered to the delivery mechanism to assure proper placement and function prior to release, would be superior to heretofore known devices. This is particularly true in view of the need to test for shunting of blood around the occluder device with the septal wall in unrestrained motion prior to release. [0019]
  • SUMMARY OF THE INVENTION
  • The present invention is a septal defect occluder which has first and second occluder panels. Each occluder panel includes a fabric support structure and fabric suspended from a perimeter thereof. The occluder panels are conjoined at a plurality of points which are located within an area bounded by the perimeter of each fabric support structure, as well as on the fabric, to thereby form a defect conforming region for the occluder. [0020]
  • In an alternate embodiment, a septal defect occluder is provided having first and second occluder panels. Each occluder panel includes a cambered fabric support structure and fabric suspended from a perimeter thereof. The occluder panels are arranged in cooperative cambered opposition such that the perimeters of the cambered fabric support structures impart a clamping force upon tissue adjacent a tissue defect interposed there between when the occluder is deployed for tissue defect occlusion. [0021]
  • The present invention is thus an improved device over structures known in the prior art. More specific features and advantages obtained in view of those features will become apparent with reference to the drawing figures and DETAILED DESCRIPTION OF THE INVENTION.[0022]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a side elevational view of the septal defect occluder of the present invention deployed in a septal defect; [0023]
  • FIG. 2 is an end view of an occluder panel of the septal defect occluder of the present invention, particularly illustrating a center fabric attachment point; [0024]
  • FIG. 3 is an end view of the frame members of the device of the subject invention having two pairs of opposing inward eyelets; [0025]
  • FIG. 4 depicts a fabric sheet suitable for use with the invention; [0026]
  • FIG. 5 is an end view of two frame members of FIG. 3 arranged to form a fabric support structure having both internal and perimeter eyelets; [0027]
  • FIG. 6 depicts a first occluder half, corresponding to the fabric support structure of FIG. 5, showing the relationship between the fabric sheet of FIG. 4 and the underlaying support structure; [0028]
  • FIG. 7 depicts a second occluder half, corresponding to the second fabric support structure of FIG. 5, showing the relationship between the fabric sheet of FIG. 4 and the underlaying support structure; [0029]
  • FIG. 8 is an overhead perspective view of an alternate occluder panel; [0030]
  • FIG. 9 is an overhead perspective view of the underlaying cambered fabric support structure of the alternate occluder panel of FIG. 8; [0031]
  • FIG. 10 is an overhead perspective view of a frame member of the cambered fabric support structure being formed using a cambered winding fixture; [0032]
  • FIG. 11 is a side view of the present invention being delivered within a catheter to a septal defect site; [0033]
  • FIG. 12 is a side view of the present invention being initially deployed within the septal defect, the second occluder half having expanded to conform to a portion of the defect; [0034]
  • FIG. 13 is a side view of the present invention deployed within the septal defect while under the control of tension imparting means; [0035]
  • FIG. 14 is a side view of the present invention being initially retrieved into the catheter from the septal defect site, the first occluder half being collapsed for catheter entry; and, [0036]
  • FIG. 15 is a side view of the present invention on its way to complete retrieval into the catheter from the septal defect site.[0037]
  • DETAILED DESCRIPTION OF THE INVENTION
  • As shown generally in FIG. 1, a septal [0038] defect closure device 20 of the invention may be attached to the septum S (e.g., an atrial septum) to effectively conform to and block the defect, without protruding into atrial cavities and the like. As described in detail below, once the closure device 20 is in place, it becomes anchored to the septum and prevents the flow of blood through the atrial septum to the adjoining chambers of the heart. This will permit the heart to operate normally.
  • Referring now to FIGS. 1 and 2, the extremely low profile closure device includes first and [0039] second occluder panels 30, 60. Each panel 30, 60 is generally round (e.g., circular, oval, elliptical etc.) so as to facilitate positioning, and minimizes chances of erosion and puncture. Each panel 30, 60 generally comprises a fabric support structure 32, 62 and fabric 33 suspended from a perimeter 34, 64 of the fabric support structures 32, 62. The occluder panels 30, 60 are conjoined at a plurality of discrete points, located or positioned within the bounds of each of the fabric support structures 32, 62 (i.e., within an area bounded by each perimeter 34, 64 of the support structures 32, 62), as well as on the fabric 33 (which will be further explained with reference to FIGS. 2, 7 and 8). A defect conforming region 80 for the occluder 20 is thereby formed. The nature (i.e., structure, relationships there between and function) of the defect conforming region will be detailed herein below, particularly with reference to FIGS. 1, 2 and 9-14. At this point it may be said that the region 80 expandingly conforms to substantially completely and thoroughly satisfy the perimeter of the defect geometry. This stabilizes panels 30, 60 so that complete coverage of the defect from either direction is achieved. The defect is thereby occluded without distortion of the defect.
  • The [0040] fabric support structures 32, 62 of the occluder are generally flexible and elastically deformable, and include perimeter and traversing segments 36, 38. Resilient fabric 33 (FIG. 4) is suspended or otherwise affixed to the perimeter segments 36 of the fabric support structures 32, 62. As particularly shown in FIG. 2, the perimeter segments 36 of the fabric support structures 32, 62 extend substantially around the periphery 35 of the fabric 33. The fabric 33 may be formed of a thin, flexible material which can be folded and pulled taut without being damaged. Elastic polymeric materials such as, for example, polyester knit, nylon, polypropylene, polytetrafluoroethylene (e.g., Teflon®), and expanded polytetrafluoroethylene (e.g., GoreTex®), as well as natural fabrics such as silk, are acceptable.
  • To accommodate the need of the fabric support structure to distort when retrieving the [0041] occluder 20 into the catheter, excess fabric can be provided. On an area basis relative to the support structure, an excess of fabric in the range, typically, of about 30-35 percent, and up to 50 percent, is sufficient. This range is required for low stretch fabric that otherwise may prevent the support structure from collapsing in a manner suitable to get into the catheter. However, the 20 denier polyester knit is advantageous in that it is of approximately 50% less bulk than known jersey style knit configurations which facilitates the use of smaller delivery catheters, and allows for the occluders to be retrieved into such catheters at forces that are not detrimental to either the catheter or the occluder (e.g., a 40 mm occluder may be pulled into a 12 French catheter using a reasonable peak force of about four pounds). A further advantage is that two complete fabric “patches” may be incorporated, into the closure device (i.e., no need to remove material to reduce bulk), which thereby creates a device having a high reliability of successful closure.
  • The [0042] fabric 33 may be attached to their respective support structures 32, 62 by any suitable means. For instance, the fabric 33 may be directly attached to the support structures 32, 62 by means of an adhesive or the like, or the periphery 35 of the fabric 33 may be wrapped about each of the support structures 32, 62 and the peripheral edge attached to the rest of the fabric so as to essentially define a sleeve about each of the support structures 32, 62. In the latter instance, the sleeve may fit the support structure relatively loosely so that the structure may move within the sleeve with respect to the fabric. The peripheral edge of the fabric may be affixed to the rest of the fabric sheet 33 in any suitable fashion such as by sewing. Preferably, though, the periphery of the fabric can be sewn to at least some portion of the perimeter segments 36 of the support structures 32, 62 using polyester, non-adsorbable suture.
  • Referring to FIG. 1, the [0043] fabric support members 32, 62 of the occluder panels 30, 60 are shown as being spaced from one another for purposes of the present explanation, but this is not the normal configuration (i.e., static condition) of the panels. In a static, non deployed condition, the fabric support structures of the device take a generally planar form, with the two fabric support structures 32, 62 generally abutting against, or closely proximate, one another.
  • Again referring to FIGS. 1 and 2, the [0044] occluder panels 30, 60 are conjoined at a plurality of discrete points, the points being selected to effectively link each of the fabric support structures 32, 62 together, as well as associate each sheet of fabric 33 carried thereby, so as to form the variably configurable defect conforming region 80. With such arrangement, the resilient fabric 33 is not only inherently or indirectly positionable in response to the defect geometry, but also directly responsive vis-a-vis the conjoined support structures 32, 62.
  • The conjoined points within the [0045] fabric support structures 32, 62, which responsively link the opposing structures, comprise loops formed in the traversing segments 38 thereof, these loops defining internal eyelets 40 for the structures 32, 62. The internal eyelets 40 of each of the structures 32, 62 are shown as being joined by suture (e.g., polyester, non-absorbable or other suitable material), and to some extent delimit the defect conforming region 80, and serve to center the occluder 20 within the defect. The remaining points of conjointment comprise the union, at a single point, of the fabric of each of the fabric support structures so as to define a generally central fabric attachment point 42. It is important that fabric 33 of each support structure 32, 62 be limitingly controlled via the union, however it is equally important that the fabric 33 remain substantially suspended for expansion during deployment, preferably exclusively about or by its periphery 35.
  • As best seen in FIG. 2, the [0046] center attachment point 42 of the occluder 20 is preferably but not exclusively configured as a sutured cross stitch positioned in the center of the fabric 33. Other attachment configurations or geometries are contemplated, to the extent that the center attachment point 42 maintains its functionality, namely that of control of the peripherally supported fabric, and generally contributing to a centering function for the occluder. Preferably the internal eyelets 40 are symmetrically oriented about the center fabric attachment point 42.
  • In addition to [0047] internal eyelets 40 which are formed in the traversing segments 38 of each of the fabric support structures 32, 62, the perimeter segments 36 of at least one (i.e., structure 62) of the fabric support structures 32, 62 include loops formed therein, thereby defining perimeter eyelets 44 for that particular support structure 62. As best seen in FIGS. 1 and 8-12, the perimeter eyelets 44 cooperate with urging means 46 carried by and or through a catheter 47 so as to aid in the symmetrical collapse of each of the fabric support structures 32, 62, and the occluder panels 30, 60 thereby, during reversible retrieval of the device 20 into the catheter 47. The perimeter eyelets 44 associated with the “catheter side” occluder panel 60 transmit and distribute deployment and retrieval forces imparted thereupon through the defect conforming region 80 and to the other occluder panel 30. As will subsequently be discussed, the unique configuration of the fabric support structure components, and the relationships there between, provide numerous advantages (for example: symmetrical collapse of the occluder, less peak force for retrieval into a catheter for deployment, and heretofore unsurpassed sealing of narrow slit defects without the distorting effects typically associated with fixed geometry conjoint areas such as circumferential conjoint disks).
  • Referring now to FIGS. [0048] 3-7, the fabric support structures comprise cooperating frames 50, each of which preferably resembles a “bowtie,” as best seen in FIG. 3. A more technical description for the frame geometry might be to characterize it as an octagon (i.e., a frame of eight legs or segments), particularly an octagon having a concave, rather than convex, “top” and “bottom” (i.e., ceiling and floor). Put yet another way, the frames resemble elongated hexagons whose long sides are “pinched” towards each other. The frames 50 may be generally characterized as having maximum and minimum dimensions and corresponding axes of maximum and minimum dimension 52, 54. The above frame description is intended to be illustrative, not limiting, with alternating frame geometries satisfying the general characterization being possible.
  • The [0049] internal eyelets 40 of the fabric support structures 32, 62 are formed in each of the frames 50 along the axis of minimum dimension 54 (FIG. 3), as illustrated. The resilient internal eyelets 40 are generally disposed between adjacent ends of two legs or frame segments 51, one end of the eyelet being attached to each leg 51. The internal eyelets 40 are shown as laying generally in the same plane as the legs 51 and may extend generally outwardly of the periphery of each of the support structures 32, 62, or may preferably extend inwardly of the periphery of the structures as shown in the figures. As will be later discussed with respect to an alternate occluder panel design, each of the frames 50, 50A of the fabric support structures 32, 62 may be cambered about their minimum dimension (i.e., the internal eyelets 40 do not lay in the same plane as the legs 51, or more specifically, the internal eyelets 40 and perimeter eyelets 44 are not coplanar) so as to, among other things, provide an occluder capable of exerting a clamping force at the perimeter edge of the tissue defect when deployed. The eyelets are desirably formed to function as spring hinges. This will serve to ensure that the occluder panels 30, 60, particularly the catheter side panel 60, elastically return substantially to a plane-defining configuration even after they have been collapsed and delivered through a catheter.
  • Frames [0050] 50 of the device have internal eyelets 40, as previously explained. The internal eyelets 40 of one fabric support structure (i.e., 32) mate (i.e., align or register) with those of the other support structure (i.e., 62) so as to thereby conjoin the occluder panels 30, 60 (FIG. 2). The perimeter eyelets 44 of fabric support structure 62 on the other hand are formed in its frames 50A along the axis of maximum dimension 54 (FIG. 3). The perimeter eyelets 44 cooperatively engage urging means 46 so as to enable remote manipulation of the occluder 20 during retrieval.
  • Each [0051] fabric support structure 32, 62 comprises perpendicularly overlaying frames, the axis of maximum dimension 52 of one frame 50 or 50A substantially aligning with the axis of minimum dimension 54 of the other frame (FIG. 5). The somewhat oversized fabric 33 is shown in FIG. 6 underlaying the cooperating frames, the periphery thereof being sewn or otherwise affixed to those portions of the frames, which when configured as shown in FIG. 5, form a perimeter 34, 64 for each of the fabric support structures 32, 62. It is again noted that the preferred fabric 33 contributes to an occluder 20 that has complete opposing fabric patches suspended by the fabric support structures 32, 62, which in turn include a frame geometry and arrangement that generally reduce deployment and retrieval forces. In return, fabric and stitch wear and tear and frame “break through” (i.e., separation of the perimeter segments 36 from the fabric 33 upon expansion of the occluders 30, 60) are minimized.
  • Each frame [0052] 50 is preferably formed of a single elongate strand of wire W. As best seen in FIG. 3, each of the legs 51 may simply comprise a length of the wire, and the wire may be bent through greater than 360 degrees to define adjacent legs 51 and to form the loops or eyelets 40, 44. The ends of the wire may be attached to each other in any secure fashion, such as by means of a weldment or a suitable biocompatible cementitious material.
  • The frames [0053] 50 should be formed of a flexible, elastically deformable material such as a metal, and the wire comprising the frame is formed of a superelastic material. One such material currently known in the art is a near-stoichiometric nickel/titanium alloy, commonly referred to as Nitinol or NiTi. Such superelastic materials may be elastically deformed to a much greater extent than most other materials, yet substantially fully recover their original shape when released. This permits the frame to be deformed sufficiently for insertion into, and passage through, a small-diameter catheter yet automatically elastically return to its initial shape upon exiting the catheter.
  • The frames are preferably manufactured with nitinol wire that can be wound around the pins of a forming die and subjected to heat treatment. Each device consists of four frames, two frames for each support structure. More particularly, each [0054] support structure 32, 62 comprises matchingly paired frame styles (i.e., as shown in FIGS. 6 and 7, occluder panel 30 has a pair of frames 50 whereas occluder panel 60 has a pair of frames 50A). All eyelets 40, 44 can be made having generally a 0.030 inch inside diameter, and, as previously noted, be inward facing (i.e., directed toward the center fabric attachment point 42). The wire ends of each frame can be connected with a titanium hypo tube using a compression crimp. The titanium is more ductile than the nitinol, providing a reliable grip with excellent corrosion resistance. Alternately, the preferred shape of the frame may be cut out from a sheet of such superelastic material as a single block, by chemical etching, punching with a suitable punch and die, or any other appropriate forming method.
  • In order to enhance radiopacity so that the frame can be viewed remotely during deployment, the frame may be provided with a radiopaque coating, such as gold or platinum. For instance, the wire W may be plated with a thin layer of gold or platinum. In one particularly useful embodiment, a helically wound length of a thin radiopaque wire (not shown) is placed over the wire W; such core/coil structures are well known in the art. Alternatively, radiopaque marking bands (not shown), which are commercially available, may be employed. By placing one such band on each leg of the frame, a physician can remotely visualize the frame as a plurality of small bands; when the bands are appropriately spaced from one another on a monitor, the physician knows that the frame is properly deployed. [0055]
  • Referring now to FIGS. 8 through 10, an alternate embodiment of the occluder panel [0056] 30 (FIG. 8) and, more particularly the fabric support structure 37 (FIG. 9), are shown for the defect occluder of the subject invention. Each occluder panel 30 includes a cambered fabric support structure 37 which otherwise conforms with/to the fabric support structure previously disclosed (i.e., the fabric support structure 37 of FIG. 8, and frame member 39 shown being formed in FIG. 10, each have the general end view appearance as the embodiment depicted in FIGS. 2 and 3 respectively, including eyelets which have been omitted from FIGS. 8 through 10 for the sake of clarity). Each of the occluder panels 30 are arranged in cooperative cambered opposition such that the perimeters 41 of the cambered fabric support structures 37 impart a clamping force upon tissue adjacent a tissue defect interposed there between when the occluder is deployed for tissue defect occlusion. Furthermore, because the entire perimeter 35 of the fabric 33 is supported by the cambered fabric support structure 37, and because the occluder panels 30 are urged together at the perimeter edge of the defect due to their arrangement in biased opposition, intimate contact of the occluder with the tissue is assured which is advantageous in supporting endothelial tissue growth during the final stages of healing.
  • The aforementioned occluder panel design substantially improves performance in the area of the occluder “go flat” characteristic. Such “go flat” characteristic (i.e., “flatness”) is specified as the distance between the perimeter edges of the occluder panels after deployment from the catheter. Heretofore known occluders, particularly larger devices (i.e., in excess of about [0057] 28 mm across), sometimes have difficulty returning to a “flat” shape (i.e., less than about 2 mm separation between occluder panels or halves) post deployment from a catheter. Force testing of smaller devices utilizing 0.007″ diameter nitinol wire indicated that the return energy of the fabric support structures was far greater than the energy in larger devices utilizing 0.010″ diameter nitinol wire, thereby permitting the fabric support structures to substantially overcome the forces associated with the fabric suspended thereover, and thus lay “flat”. Solution of the “go flat” problem via an increase in frame wire diameter yielded a less than desirable catheter retrieval force, namely a retrieval force in excess of 5 lbs. Occluder panels having a cambered fabric support structure, and alignment of the panels in biased opposition, provide a tissue defect occluder having a preloaded or added energy effect without increasing wire diameter, and thereby increasing catheter retrieval force.
  • Each of the frame members or [0058] elements 39 of each of the fabric support structures 37 are cambered about their minimum dimension 43 (i.e., the internal eyelets do not lay in the same plane as the legs, or more specifically, the internal eyelets and perimeter eyelets are not coplanar). Said another way, each frame element 39 has a camber axis 45 which is in substantial conformity with the axis of minimum dimension 43, compare FIGS. 3 and 10. Each cambered fabric support structure 37 comprises perpendicularly overlaying frames 39, the axis of maximum dimension 48 of one frame substantially aligning with the axis of minimum dimension 43 and camber 45 of the other frame. Furthermore, as best seen in FIGS. 8 and 9, the cambered frame members 39 are arranged in forming the cambered fabric support structure 49 such that a support structure apex 49 is formed, the apex 49 being defined as the intersection of camber axis 45 for the cooperating frame members 39. The somewhat oversized fabric 33 indicated by dashed line in FIG. 8, has a periphery 35 sewn or otherwise affixed, as the embodiment illustrated in FIGS. 2, 6, and 7, to those portions of the frame elements 39 which form a perimeter 41 for each of the fabric support structures 37. It is again noted that the preferred fabric carried by the fabric support structures of the subject invention contributes to an occluder that has complete opposing fabric patches suspended by the cambered fabric support structures, which in turn yields a preloaded frame geometry and occluder panel arrangement that generally reduces deployment and retrieval forces while enhancing the stay flat characteristics of the device.
  • Although the cambered frame members which comprise the cambered fabric support structures are manufactured much like the “planar” frames of FIG. 3, namely with nitinol wire that can be wound around the [0059] pins 53 of a forming die 55 and subjected to heat treatment, during the winding process, a biasing mandrel (not shown) is used in combination with the forming die 55 to form the cambered frame member 39. Alternately, the forming die 55 itself may be contoured so as to produce a cambered frame as is depicted in FIG. 10.
  • As with the case of the occluder of FIGS. 1 and 2, the occluder panels are conjoined at a plurality of discrete points, the points being selected to effectively link each of the cambered fabric support structures together, as well as associate each sheet of fabric carried thereby, so as to form the variably configurable defect conforming region. With such arrangement, the resilient fabric is not only inherently or indirectly positionable in response to the defect geometry, but also directly responsive vis-a-vis the conjoined support structures. [0060]
  • Referring now to FIGS. 11 through 15, the [0061] general closure device 20 of the invention (i.e., those embodiments previously described) is shown being deployed to occlude a defect in a septum S. The first panel 60 (i.e., catheter side occluder panel) of the device 20 is positioned on one side of the defect while the second panel 30 is generally disposed on the other side. The frames 50 or 50A of the fabric support structures 32, 62 are elastically biased toward the position shown in FIG. 2. The defect conforming region 80 is positioned within, and expands so as to occlude the defect. Because the support structures 32, 62, vis-a-vis their frames 50 or 50A, are elastically biased toward their deployed configuration, they are biased generally toward one another and engage opposing sides of the septum about the defect. Since there are no compressive forces acting on the frames which might cause them to collapse, this serves to effectively hold the device in place and occlude the defect. The device is further shown in FIGS. 14 and 15 being retrieved from a septal defect site, as might be required in the event of inadvertent initial placement, size mismatch, or otherwise.
  • The [0062] fabric sheets 33 are formed of a relatively porous material (FIG. 4). While this may seem to contradict the purpose of the device, blood will tend to coagulate on the latticework provided by the porous material. Blood flow across the defect is usually substantially blocked after minimal time passage. If so desired, the conjoint portion of the device (or the entire device) may be treated with a thrombogenic agent to speed this natural process or may be impregnated with a biocompatible polymeric compound or the like to make it relatively impervious to fluids.
  • The primary purpose of using a porous fabric is to accelerate the process of permanently anchoring the device in place. The support structures hold the fabric tautly and in intimate contact with the surface of the septum S. This intimate contact between the septum and perimeter of the occluder permits ingrowth of collagen and fibrous tissue from the septum into the fabric. Over time, the membrane resting against the septum will become securely anchored to the septal wall and be covered by a layer of endothelial cells. [0063]
  • The design of this device is in stark contrast to the septal defect closure devices known in the art. As explained in detail above, prior art devices employ a mechanical umbrella of one design or another. The radially extending arms of the umbrella contact the septum and serve to space all but the peripheral edge of the umbrella away from the septum. Endothelial cells, collagen and fibrous tissue are therefore permitted to grow into only the very periphery of the umbrella. Thus, while a closure device of the invention essentially becomes an integral part of the septum, the complex mechanical structure of prior art devices does not enable as complete integration as the present invention. [0064]
  • The mechanical complexity of prior art devices also tends to markedly affect their durability. In the case of atrial or ventricular septal defects, for example, the heart obviously continues to beat after the device is in place. Since beating of the heart is accomplished by flexure of the heart muscles, the septum will flex to some degree with every beat of the heart. The radial arms must therefore flex with the septum with each and every time the heart beat. The number of cycles of this stress-inducing movement produces repeated stresses on the arms, which can eventually lead to mechanical failure and fracture of the arms. [0065]
  • When a closure device of the invention is deployed, the tension of the frame of the support structure opens the panel to occlude the defect. Since there are no radial arms to prop open the device, the occurrence of repeated flexion does not occur due to the beating of the heart or pressure differences between the cardiac chamber during the phase of contraction of the heart. To the contrary, any pressure difference would urge a frame and panel against the septum, more firmly occluding the defect. In addition, the superelastic material of the frame tolerates flexural stresses much better than the rigid steel arms of the prior art devices. The present device therefore will continue to flex with the septum without any significant effect on its structural integrity. [0066]
  • Although the foregoing has focused on application of the present invention to occlude atrial septal defects, the invention is not limited to occluding such defects. For instance, the instant closure device can be used to treat ventricular septal defects, patent ductus arteriosus, patent foramen ovale (PFO), or any other congenital or acquired orificial or tubular communications between vascular chambers or vessels. [0067]
  • While a preferred embodiment of the present invention has been described, it should be understood that various changes, adaptations and modifications may be made therein without departing from the spirit of the invention. Changes may be made in details, particularly in matters of shape, size, material, and arrangement of parts without exceeding the scope of the invention. Accordingly, the scope of the invention is as defined in the language of the appended claims. [0068]
    ATTACHMENT A
    SER. NO. FILING DATE PATENT NO. ISSUE DATE
    2. 09/760,056 Jan. 1, 2001
    3. 09/628,211 Jul. 28, 2000 6,440,152 B1 Aug. 27, 2002
    4. 10/227,773 Aug. 26, 2002
    5. 09/628,212 Jul. 28, 2000
    6. 09/631,482 Aug. 3, 2000
    7. 09/936,248 Sep. 7, 2001
    8. 10/184,327 Jun. 27, 2002
    9. 09/981,769 Oct. 17, 2001
    10. 10/074,740 Feb. 12, 2002
    11. 10/056,588 Jan. 23, 2002
    12. 10/100,686 Mar. 14, 2002
    13. 10/165,803 Jun. 7, 2003
    14. 10/209,797 Jul. 30, 2002
    15. 10/290,426 Nov. 7, 2002
    16. 10/290,392 Nov. 7, 2002
  • Article Five
  • The Agreement of Merger is on file at the following place of business of the Surviving Company: ev3 Inc., 1861 Buerkle Road, White Bear Lake, Minn. 55110. [0069]
  • Article Six
  • A copy of the Agreement of Merger will be furnished by the Surviving Company, on request and without cost, to any stockholder of any constituent corporation. [0070]
  • Article Seven
  • The aggregate number of shares of stock which the Merging Company has authority to issue is 35,450,000 shares, which consist of 32,500,000 shares of Class A Common Stock, 200,000 shares of Class B Common Stock, 1,600,000 shares of Series A Convertible Preferred Stock, 150,000 shares of Series B Convertible Preferred Stock, 347,755 shares of Series C Convertible Preferred Stock and 652,245 shares of undesignated stock. The par value of each share of capital stock of the Merging Company is 5.01. [0071]

Claims (26)

What is claimed is:
1. A tissue defect occluder comprising first and second occluder panels, each occluder panel including a cambered fabric support structure and fabric suspended from a perimeter of said cambered fabric support structure, said occluder panels being arranged in cooperative cambered opposition such that the perimeters of said cambered fabric support structures impart a clamping force upon tissue adjacent a tissue defect interposed there between when said occluder is deployed for tissue defect occlusion.
2. The occluder of claim 1 wherein the retrieval force into a catheter for said occluder is less than five pounds.
3. The occluder of claim 2 wherein the distance between the perimeter edges of the occluder panels is less than two millimeters post deployment from a catheter.
4. The occluder of claim 3 wherein the camber of said cambered fabric support structure is about 15% of the diameter of said cambered fabric support structure.
5. The occluder of claim 1 wherein said occluder panels are conjoined at a plurality of discrete points to thereby form a defect conforming region.
6. The occluder of claim 5 wherein said discrete conjoined points are located within each of the cambered fabric support structures, as well as on said fabric.
7. The occluder of claim 6 wherein said cambered fabric support structure includes perimeter and traversing segments.
8. The occluder of claim 7 wherein the conjoined points within the cambered fabric support structure comprise loops formed in the traversing segments of each of the cambered fabric support structures, thereby defining internal eyelets for said support structures.
9. The occluder of claim 8 wherein said internal eyelets substantially delimit said defect conforming region.
10. The occluder of claim 9 wherein the fabric of each of said cambered fabric support structures is conjoined at a single location so as to define a center fabric attachment point for said occluder.
11. The occluder of claim 10 wherein the perimeter segments of at least one of said cambered fabric support structures include loops formed therein, thereby defining perimeter eyelets for said support structure, said perimeter eyelets aiding in the symmetrical collapse of said cambered fabric support structure as during reversible retrieval of said occluder into a catheter.
12. The occluder of claim 11 wherein said internal eyelets are symmetrical about said center fabric attachment point.
13. The occluder of claim 12 wherein said fabric comprises a polymeric material.
14. The occluder of claim 13 wherein said polymeric material comprises a polyester knit.
15. The occluder of claim 13 wherein said polymeric material comprises a 20 denier polyester knit.
16. The occluder of claim 15 wherein said occluder panels are substantially round.
17. A septal defect occluder comprising first and second occluder panels, each panel including a cambered fabric support structure and fabric substantially affixed to a perimeter thereof, each of said cambered fabric support structures comprising cooperating cambered frames, the occluder panels being conjoined at internal frame points located within the perimeter of each of said cambered fabric support structures, the fabric of each of said cambered fabric support structures being joined so as to form a center fabric attachment point.
18. The occluder of claim 17 wherein each of said cooperating cambered frames has an axis of maximum dimension and an axis of minimum dimension.
19. The occluder of claim 17 wherein each of said cooperating cambered frames further has a camber axis, said camber axis being in substantial conformity with said axis of minimum dimension.
20. The occluder of claim 19 wherein said cooperating cambered frames are perpendicularly overlaying, the axis of maximum dimension of one frame substantially aligning with the axis of minimum dimension of the other frame.
21. The occluder of claim 20 wherein said internal frame points comprise loops formed in each of said cambered frames, said loops delimiting a minimum frame dimension and thereby defining internal eyelets for each of said cambered fabric support structures.
22. The occluder of claim 21 wherein the frames of one of said cambered fabric support structures comprise loops formed in said frame of one of said fabric support structures, said loops delimiting a maximum frame dimension and thereby defining perimeter eyelets for said cambered fabric support structure.
23. The occluder of claim 22 wherein said perimeter eyelets cooperatively engage means for urging said occluder from a catheter for reversible deployment in and about a septal defect site.
24. The occluder of claim 23 wherein said fabric comprises a polymeric material.
25. The occluder of claim 24 wherein said polymeric material comprises a polyester knit.
26. The occluder of claim 24 wherein said polymeric material comprises a 20 denier polyester knit.
US10/419,412 2000-04-26 2003-04-21 Septal defect occluder Abandoned US20030195530A1 (en)

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US10/419,412 US20030195530A1 (en) 2000-04-26 2003-04-21 Septal defect occluder

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Cited By (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020198563A1 (en) * 2000-07-28 2002-12-26 Microvena Corporation Defect occluder release assembly & method
US20040010287A1 (en) * 1999-08-09 2004-01-15 Bonutti Peter M. Method and apparatus for securing tissue
US20040181256A1 (en) * 2003-03-14 2004-09-16 Glaser Erik N. Collet-based delivery system
US20050119675A1 (en) * 2003-10-24 2005-06-02 Adams Daniel O. Patent foramen ovale closure system
US20060036284A1 (en) * 2002-05-06 2006-02-16 Velocimed, Llc PFO closure devices and related methods of use
US20060052804A1 (en) * 2002-11-15 2006-03-09 Claude Mialhe Occlusive device for medical or surgical use
US20060200199A1 (en) * 2005-02-22 2006-09-07 Bonutti Peter M Device and method for securing body tissue
US20060217760A1 (en) * 2005-03-17 2006-09-28 Widomski David R Multi-strand septal occluder
US20060224224A1 (en) * 2005-03-31 2006-10-05 Lambert Muhlenberg Trans-septal/trans-myocardial ventricular pacing lead
US20060229623A1 (en) * 2004-10-26 2006-10-12 Bonutti Peter M Tissue fixation system and method
US20060241687A1 (en) * 2005-03-16 2006-10-26 Glaser Erik N Septal occluder with pivot arms and articulating joints
US20070016250A1 (en) * 2003-04-11 2007-01-18 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US20070112382A1 (en) * 2001-08-01 2007-05-17 Microvena Corporation Tissue opening occluder
US20070244494A1 (en) * 2006-04-18 2007-10-18 Downing Stephen W Methods and devices for treating atrial septal defects
US20080009888A1 (en) * 2006-07-07 2008-01-10 Usgi Medical, Inc. Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US20090082804A1 (en) * 2005-03-29 2009-03-26 Terumo Kabushiki Kaisha Defect-Closure Device and Delivery Apparatus
JP2009536550A (en) * 2006-05-10 2009-10-15 ミネソタ メディカル ディベロップメント、インコーポレイテッド Hernia patch production method and resulting product
US7648532B2 (en) 2003-05-19 2010-01-19 Septrx, Inc. Tissue distention device and related methods for therapeutic intervention
US7658747B2 (en) 2003-03-12 2010-02-09 Nmt Medical, Inc. Medical device for manipulation of a medical implant
US7666203B2 (en) 2003-11-06 2010-02-23 Nmt Medical, Inc. Transseptal puncture apparatus
US7678132B2 (en) 2001-09-06 2010-03-16 Ovalis, Inc. Systems and methods for treating septal defects
US7678123B2 (en) 2003-07-14 2010-03-16 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US7691112B2 (en) 2003-09-11 2010-04-06 Nmt Medical, Inc. Devices, systems, and methods for suturing tissue
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
US7717937B2 (en) 2001-06-01 2010-05-18 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US7740640B2 (en) 2001-09-06 2010-06-22 Ovalis, Inc. Clip apparatus for closing septal defects and methods of use
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
US7780700B2 (en) 2003-02-04 2010-08-24 ev3 Endovascular, Inc Patent foramen ovale closure system
US7797056B2 (en) 2005-09-06 2010-09-14 Nmt Medical, Inc. Removable intracardiac RF device
US20100234878A1 (en) * 2009-03-16 2010-09-16 Cook Incorporated Closure device with string retractable umbrella
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US7867250B2 (en) 2001-12-19 2011-01-11 Nmt Medical, Inc. Septal occluder and associated methods
US7871419B2 (en) 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US7963952B2 (en) 2003-08-19 2011-06-21 Wright Jr John A Expandable sheath tubing
US7967840B2 (en) 2001-12-19 2011-06-28 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US7988690B2 (en) 2004-01-30 2011-08-02 W.L. Gore & Associates, Inc. Welding systems useful for closure of cardiac openings
US8070826B2 (en) 2001-09-07 2011-12-06 Ovalis, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US8257389B2 (en) 2004-05-07 2012-09-04 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
US8262694B2 (en) 2004-01-30 2012-09-11 W.L. Gore & Associates, Inc. Devices, systems, and methods for closure of cardiac openings
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8292910B2 (en) 2003-11-06 2012-10-23 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8372113B2 (en) 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
US8372112B2 (en) 2003-04-11 2013-02-12 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US8747439B2 (en) 2000-03-13 2014-06-10 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US8753362B2 (en) 2003-12-09 2014-06-17 W.L. Gore & Associates, Inc. Double spiral patent foramen ovale closure clamp
US8764848B2 (en) 2004-09-24 2014-07-01 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US8784448B2 (en) 2002-06-05 2014-07-22 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
US8814902B2 (en) 2000-05-03 2014-08-26 Bonutti Skeletal Innovations Llc Method of securing body tissue
US8814947B2 (en) 2006-03-31 2014-08-26 W.L. Gore & Associates, Inc. Deformable flap catch mechanism for occluder device
US8828049B2 (en) 2004-04-09 2014-09-09 W.L. Gore & Associates, Inc. Split ends closure device and methods of use
US8828051B2 (en) 2010-07-02 2014-09-09 Pfm Medical Ag Left atrial appendage occlusion device
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US20140364872A1 (en) * 2013-06-05 2014-12-11 Lc Therapeutics, Inc. Tissue anchor and deployment device for same
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US9017373B2 (en) 2002-12-09 2015-04-28 W.L. Gore & Associates, Inc. Septal closure devices
US9060767B2 (en) 2003-04-30 2015-06-23 P Tech, Llc Tissue fastener and methods for using same
US9084603B2 (en) 2005-12-22 2015-07-21 W.L. Gore & Associates, Inc. Catch members for occluder devices
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US9149281B2 (en) 2002-03-20 2015-10-06 P Tech, Llc Robotic system for engaging a fastener with body tissue
US9173650B2 (en) 2006-02-07 2015-11-03 P Tech, Llc Methods and devices for trauma welding
US9216014B2 (en) 2002-06-03 2015-12-22 W.L. Gore & Associates, Inc. Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof
US9226828B2 (en) 2004-10-26 2016-01-05 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9241695B2 (en) 2002-03-25 2016-01-26 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure clips
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9402668B2 (en) 2007-02-13 2016-08-02 P Tech, Llc Tissue fixation system and method
US9439642B2 (en) 2006-02-07 2016-09-13 P Tech, Llc Methods and devices for utilizing bondable materials
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9474517B2 (en) 2008-03-07 2016-10-25 W. L. Gore & Associates, Inc. Heart occlusion devices
US9750496B2 (en) 2002-08-27 2017-09-05 P Tech, Llc System for securing a portion of a body
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US9888916B2 (en) 2004-03-09 2018-02-13 P Tech, Llc Method and device for securing body tissue
US9986994B2 (en) 2000-03-13 2018-06-05 P Tech, Llc Method and device for securing body tissue
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
CN110049792A (en) * 2016-11-23 2019-07-23 马真塔医药有限公司 Blood pump
US10792025B2 (en) 2009-06-22 2020-10-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10806437B2 (en) 2009-06-22 2020-10-20 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US11129645B2 (en) 2006-02-07 2021-09-28 P Tech, Llc Methods of securing a fastener
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US11844913B2 (en) 2012-03-23 2023-12-19 Boston Scientific Medical Device Limited Transseptal puncture apparatus and method for using the same

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4082497A (en) 1996-08-22 1998-03-06 Trustees Of Columbia University, The Endovascular flexible stapling device
US7044134B2 (en) 1999-11-08 2006-05-16 Ev3 Sunnyvale, Inc Method of implanting a device in the left atrial appendage
US7713282B2 (en) 1998-11-06 2010-05-11 Atritech, Inc. Detachable atrial appendage occlusion balloon
US7128073B1 (en) 1998-11-06 2006-10-31 Ev3 Endovascular, Inc. Method and device for left atrial appendage occlusion
AU5812299A (en) * 1999-09-07 2001-04-10 Microvena Corporation Retrievable septal defect closure device
US8083766B2 (en) * 1999-09-13 2011-12-27 Rex Medical, Lp Septal defect closure device
US6994092B2 (en) * 1999-11-08 2006-02-07 Ev3 Sunnyvale, Inc. Device for containing embolic material in the LAA having a plurality of tissue retention structures
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
EP1326524B1 (en) 2000-10-19 2010-09-01 Applied Medical Resources Corporation Surgical access apparatus and method
JP4324471B2 (en) 2001-08-14 2009-09-02 アプライド メディカル リソーシーズ コーポレイション Access path sealing device
US20080015633A1 (en) * 2001-09-06 2008-01-17 Ryan Abbott Systems and Methods for Treating Septal Defects
US7226466B2 (en) * 2001-09-06 2007-06-05 Nmt Medical, Inc. Flexible delivery system
US7052454B2 (en) * 2001-10-20 2006-05-30 Applied Medical Resources Corporation Sealed surgical access device
US6958037B2 (en) 2001-10-20 2005-10-25 Applied Medical Resources Corporation Wound retraction apparatus and method
US6814743B2 (en) * 2001-12-26 2004-11-09 Origin Medsystems, Inc. Temporary seal and method for facilitating anastomosis
JP2005525843A (en) * 2002-01-14 2005-09-02 エヌエムティー メディカル インコーポレイテッド Patent foramen ovale (PFO) occlusion method and apparatus
WO2003103548A1 (en) 2002-06-05 2003-12-18 Applied Medical Resources Corporation Wound retractor
EP1526810B1 (en) * 2002-07-31 2009-04-15 Abbott Laboratories Vascular Enterprises Limited Apparatus for sealing surgical punctures
DE60317909T2 (en) * 2002-09-23 2008-11-13 NMT Medical, Inc., Boston DEVICE FOR PUNCTING A SEPTUMS
WO2004043508A1 (en) * 2002-11-06 2004-05-27 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
AU2003287689A1 (en) * 2002-11-07 2004-06-03 Nmt Medical, Inc. Patent foramen ovale (pfo) closure with magnetic force
DE10302447B4 (en) * 2003-01-21 2007-12-06 pfm Produkte für die Medizin AG Occlusion device, placement system, set of such a placement system and such occlusion device and method for producing an occlusion device
US7087072B2 (en) * 2003-01-22 2006-08-08 Cardia, Inc. Articulated center post
US20040254594A1 (en) * 2003-01-24 2004-12-16 Arthur Alfaro Cardiac defect occlusion device
US20050020884A1 (en) 2003-02-25 2005-01-27 Hart Charles C. Surgical access system
US20040176788A1 (en) * 2003-03-07 2004-09-09 Nmt Medical, Inc. Vacuum attachment system
DE602004018282D1 (en) * 2003-03-17 2009-01-22 Ev3 Endovascular Inc STENT WITH LAMINATED THIN FILM LINKAGE
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
AU2004226374B2 (en) * 2003-03-27 2009-11-12 Terumo Kabushiki Kaisha Methods and apparatus for treatment of patent foramen ovale
US7165552B2 (en) * 2003-03-27 2007-01-23 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7597704B2 (en) * 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US7621948B2 (en) * 2003-07-21 2009-11-24 The Trustees Of The University Of Pennsylvania Percutaneous heart valve
AU2004263142A1 (en) 2003-08-06 2005-02-17 Applied Medical Resources Corporation Surgical device with tack-free gel and method of manufacture
US7735493B2 (en) * 2003-08-15 2010-06-15 Atritech, Inc. System and method for delivering a left atrial appendage containment device
DE602004015807D1 (en) * 2003-09-11 2008-09-25 Nmt Medical Inc CUTTING TUBE FOR SURGICAL SEAMS
US7163510B2 (en) 2003-09-17 2007-01-16 Applied Medical Resources Corporation Surgical instrument access device
US7144410B2 (en) * 2003-09-18 2006-12-05 Cardia Inc. ASD closure device with self centering arm network
US20050070939A1 (en) * 2003-09-30 2005-03-31 Jean Beaupre Unfolding anastomosis ring device
US20050192627A1 (en) * 2003-10-10 2005-09-01 Whisenant Brian K. Patent foramen ovale closure devices, delivery apparatus and related methods and systems
CA2542089A1 (en) * 2003-10-10 2005-04-21 Proximare, Inc. Patent foramen ovale (pfo) closure devices, delivery apparatus and related methods and systems
US7419498B2 (en) * 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US20050113868A1 (en) * 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
US20060106447A1 (en) * 2004-01-26 2006-05-18 Nmt Medical, Inc. Adjustable stiffness medical system
US20050187568A1 (en) * 2004-02-20 2005-08-25 Klenk Alan R. Devices and methods for closing a patent foramen ovale with a coil-shaped closure device
EP2308425B2 (en) 2004-03-11 2023-10-18 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous Heart Valve Prosthesis
US20050234509A1 (en) * 2004-03-30 2005-10-20 Mmt Medical, Inc. Center joints for PFO occluders
US20050256532A1 (en) * 2004-05-12 2005-11-17 Asha Nayak Cardiovascular defect patch device and method
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US20050283218A1 (en) * 2004-06-22 2005-12-22 Williams Michael S Implantable chamber for biological induction or enhancement of muscle contraction
JP4418785B2 (en) 2004-09-29 2010-02-24 テルモ株式会社 Patent application for patent foramen ovale and instrument for patent foramen ovale
US7722629B2 (en) * 2004-10-29 2010-05-25 Jeffrey W. Chambers, M.D. System and method for catheter-based septal defect repair
US9545300B2 (en) * 2004-12-22 2017-01-17 W. L. Gore & Associates, Inc. Filament-wound implantable devices
US20060149137A1 (en) * 2005-01-05 2006-07-06 Applied Medical Resources Corporation Easily placeable and removable wound retractor
WO2006110830A2 (en) 2005-04-11 2006-10-19 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
JP4744191B2 (en) * 2005-05-18 2011-08-10 テルモ株式会社 In vivo tissue closure device
US7972359B2 (en) 2005-09-16 2011-07-05 Atritech, Inc. Intracardiac cage and method of delivering same
US20070088388A1 (en) * 2005-09-19 2007-04-19 Opolski Steven W Delivery device for implant with dual attachment sites
DE602006012518D1 (en) 2005-10-14 2010-04-08 Applied Med Resources WIND HOOK WITH PARTIAL TIRE AND GELPAD
JP2009512521A (en) * 2005-10-24 2009-03-26 エヌエムティー メディカル, インコーポレイティッド Radiopaque bioabsorbable occluder
US20070135826A1 (en) 2005-12-01 2007-06-14 Steve Zaver Method and apparatus for delivering an implant without bias to a left atrial appendage
US20090036920A1 (en) * 2006-03-22 2009-02-05 Radi Medical Systems Ab Closure device
EP2012710A2 (en) * 2006-04-27 2009-01-14 Wilfrido Castaneda Methods and apparatus for extraluminal femoropoliteal bypass graft
US20070270905A1 (en) * 2006-05-18 2007-11-22 Cook Incorporated Patent foramen ovale closure device and method
US7972361B2 (en) * 2006-06-19 2011-07-05 Cardia, Inc. Occlusion device with flexible spring connector
US7749238B2 (en) * 2006-06-19 2010-07-06 Cardia, Inc. Occlusion device with flexible polymeric connector
US7691115B2 (en) * 2006-06-19 2010-04-06 Cardia, Inc. Occlusion device with flexible fabric connector
US7927351B2 (en) * 2006-06-19 2011-04-19 Cardia, Inc. Occlusion device with flexible wire connector
US8979941B2 (en) * 2006-08-09 2015-03-17 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US8864809B2 (en) 2006-08-09 2014-10-21 Coherex Medical, Inc. Systems and devices for reducing the size of an internal tissue opening
US8529597B2 (en) 2006-08-09 2013-09-10 Coherex Medical, Inc. Devices for reducing the size of an internal tissue opening
US20080051830A1 (en) * 2006-08-24 2008-02-28 Boston Scientific Scimed, Inc. Occluding device and method
DE102006045545A1 (en) * 2006-09-25 2008-04-03 Peter Osypka Stiftung Stiftung des bürgerlichen Rechts Medical device
EP2263605A1 (en) * 2006-11-20 2010-12-22 SeptRx, Inc. Device and method for preventing the undesired passage of emboli from a venous blood pool to an arterial blood pool
US20080161825A1 (en) * 2006-11-20 2008-07-03 Stout Medical Group, L.P. Anatomical measurement tool
US20080167682A1 (en) * 2007-01-09 2008-07-10 Cardia, Inc. Bioabsorbable occlusion device
WO2008094706A2 (en) 2007-02-01 2008-08-07 Cook Incorporated Closure device and method of closing a bodily opening
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
US8070802B2 (en) * 2007-02-23 2011-12-06 The Trustees Of The University Of Pennsylvania Mitral valve system
US20080208328A1 (en) * 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
US8109873B2 (en) 2007-05-11 2012-02-07 Applied Medical Resources Corporation Surgical retractor with gel pad
US8226552B2 (en) 2007-05-11 2012-07-24 Applied Medical Resources Corporation Surgical retractor
US8034061B2 (en) 2007-07-12 2011-10-11 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
WO2009052432A2 (en) 2007-10-19 2009-04-23 Coherex Medical, Inc. Medical device for modification of left atrial appendange and related systems and methods
EP2237815B1 (en) * 2008-01-22 2020-08-19 Applied Medical Resources Corporation Surgical instrument access device
WO2009121001A1 (en) * 2008-03-28 2009-10-01 Coherex Medical, Inc. Delivery systems for a medical device and related methods
US20110184439A1 (en) * 2008-05-09 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biological Matrix for Cardiac Repair
CA2739910C (en) 2008-10-13 2017-06-06 Applied Medical Resources Corporation Single port access system
WO2010081041A1 (en) 2009-01-08 2010-07-15 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US10702275B2 (en) * 2009-02-18 2020-07-07 St. Jude Medical Cardiology Division, Inc. Medical device with stiffener wire for occluding vascular defects
US10631969B2 (en) * 2009-06-17 2020-04-28 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
CA2958338C (en) 2009-06-17 2019-04-16 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9649115B2 (en) 2009-06-17 2017-05-16 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
US9351716B2 (en) 2009-06-17 2016-05-31 Coherex Medical, Inc. Medical device and delivery system for modification of left atrial appendage and methods thereof
US10064628B2 (en) 2009-06-17 2018-09-04 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
ES2776949T3 (en) * 2009-08-31 2020-08-03 Applied Med Resources Multifunctional Surgical Access System
WO2011056981A2 (en) 2009-11-04 2011-05-12 Nitinol Devices And Components, Inc. Alternating circumferential bridge stent design and methods for use thereof
DE102010021345A1 (en) * 2010-05-22 2011-11-24 Acoredis Gmbh Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall
US9138212B1 (en) * 2010-07-19 2015-09-22 Cardica, Inc. Anchor system for PFO closure
EP2621348B1 (en) 2010-10-01 2019-06-12 Applied Medical Resources Corporation Natural orifice surgery system
US9289115B2 (en) 2010-10-01 2016-03-22 Applied Medical Resources Corporation Natural orifice surgery system
WO2012047308A1 (en) 2010-10-08 2012-04-12 Nitinol Devices And Components, Inc. Alternating circumferential bridge stent design and methods for use thereof
WO2012051489A2 (en) 2010-10-15 2012-04-19 Cook Medical Technologies Llc Occlusion device for blocking fluid flow through bodily passages
DE102011077731A1 (en) 2010-11-12 2012-05-16 Acoredis Gmbh Approximately cylindrical occluder for treating atrial septal defect and patent foramen ovale, comprises elastic-plastic material with base surface, cover surface and skin surface
CA2828960A1 (en) 2011-03-02 2012-09-07 Joe Michael Eskridge Endovascular closure system
US10201336B2 (en) 2011-03-25 2019-02-12 St. Jude Medical, Cardiology Division, Inc. Device and method for delivering a vascular device
US8821529B2 (en) 2011-03-25 2014-09-02 Aga Medical Corporation Device and method for occluding a septal defect
EP2693981A4 (en) * 2011-04-01 2015-07-01 Univ Cornell Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen
EP3711682B1 (en) 2011-05-10 2022-10-19 Applied Medical Resources Corporation Wound retractor
US11154284B2 (en) * 2011-07-15 2021-10-26 Nanyang Technological University Occlusion device for closing anatomical defects
EP4324409A2 (en) 2011-11-01 2024-02-21 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
EP3281608B1 (en) 2012-02-10 2020-09-16 CVDevices, LLC Medical product comprising a frame and visceral pleura
US20140039598A1 (en) * 2012-07-30 2014-02-06 Gregory C. Sampognaro Blood loss control system
CA2900862C (en) 2013-02-11 2017-10-03 Cook Medical Technologies Llc Expandable support frame and medical device
US20140275794A1 (en) 2013-03-15 2014-09-18 Applied Medical Resources Corporation Mechanical Gel Surgical Access Device
WO2014185230A1 (en) * 2013-05-15 2014-11-20 グンゼ株式会社 Medical material
US10004512B2 (en) * 2014-01-29 2018-06-26 Cook Biotech Incorporated Occlusion device and method of use thereof
KR101590323B1 (en) * 2014-03-17 2016-02-01 주식회사 에스앤지바이오텍 Stent for Sealing of Gastrointesitnal Leaks
DE102014006984A1 (en) 2014-05-08 2015-11-26 Acoredis Gmbh Occlusion device or occluder (closure device) for heart defects and their production
CN104000629A (en) * 2014-05-26 2014-08-27 山东省立医院 Ventricular septal defect occluder
KR102444866B1 (en) 2014-07-18 2022-09-19 어플라이드 메디컬 리소시스 코포레이션 Gels having permanent tack free coatings and method of manufacture
ES2731049T3 (en) 2014-08-15 2019-11-13 Applied Med Resources Natural hole surgery system
JP2017535399A (en) 2014-11-25 2017-11-30 アプライド メディカル リソーシーズ コーポレイション Surrounding wound retraction with support and guidance structure
EP3284412A1 (en) 2014-12-02 2018-02-21 4Tech Inc. Off-center tissue anchors
DE102014018086A1 (en) 2014-12-04 2016-06-09 Acoredis Gmbh Multifunctional occluder for occluding PFO and ASD defects and producing them
EP4151165A1 (en) 2015-09-15 2023-03-22 Applied Medical Resources Corporation Surgical robotic access system
ES2951168T3 (en) 2015-10-07 2023-10-18 Applied Med Resources Multi-segment outer ring wound retractor
JP7021200B2 (en) 2016-09-12 2022-02-16 アプライド メディカル リソーシーズ コーポレイション Surgical robot access system
CN108261214B (en) * 2016-12-31 2020-06-12 先健科技(深圳)有限公司 Occluder and method for suturing occluder
AU2018200129A1 (en) * 2017-02-21 2018-09-06 Coherex Medical, Inc. Medical device for modification of left atrial appendage and related systems and methods
WO2018200891A1 (en) 2017-04-27 2018-11-01 Boston Scientific Scimed, Inc. Occlusive medical device with fabric retention barb
US20180333150A1 (en) * 2017-05-16 2018-11-22 Edwards Lifesciences Corporation Trans-septal closure device
US10441258B2 (en) 2017-06-16 2019-10-15 Cardia, Inc. Uncoupled LAA device
US9848906B1 (en) 2017-06-20 2017-12-26 Joe Michael Eskridge Stent retriever having an expandable fragment guard
US10993807B2 (en) 2017-11-16 2021-05-04 Medtronic Vascular, Inc. Systems and methods for percutaneously supporting and manipulating a septal wall
US10952741B2 (en) 2017-12-18 2021-03-23 Boston Scientific Scimed, Inc. Occlusive device with expandable member
US11413048B2 (en) 2018-01-19 2022-08-16 Boston Scientific Scimed, Inc. Occlusive medical device with delivery system
CN111655199B (en) * 2018-01-22 2023-09-26 爱德华兹生命科学公司 Heart-shaped maintenance anchor
JP2020537563A (en) * 2018-02-09 2020-12-24 4テック インコーポレイテッド Frustrated cone-shaped hemostatic seal element
EP3787484A1 (en) 2018-05-02 2021-03-10 Boston Scientific Scimed Inc. Occlusive sealing sensor system
US11241239B2 (en) 2018-05-15 2022-02-08 Boston Scientific Scimed, Inc. Occlusive medical device with charged polymer coating
WO2019237022A1 (en) 2018-06-08 2019-12-12 Boston Scientific Scimed, Inc. Occlusive device with actuatable fixation members
EP3801300A1 (en) 2018-06-08 2021-04-14 Boston Scientific Scimed, Inc. Medical device with occlusive member
WO2020010201A1 (en) 2018-07-06 2020-01-09 Boston Scientific Scimed, Inc. Occlusive medical device
CN112714632A (en) 2018-08-21 2021-04-27 波士顿科学医学有限公司 Barbed protruding member for cardiovascular devices
US11759189B2 (en) * 2018-12-12 2023-09-19 Lap Iq, Inc. Implantable tissue scaffold
US11369355B2 (en) 2019-06-17 2022-06-28 Coherex Medical, Inc. Medical device and system for occluding a tissue opening and method thereof
WO2021041831A1 (en) 2019-08-30 2021-03-04 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
US11903589B2 (en) 2020-03-24 2024-02-20 Boston Scientific Scimed, Inc. Medical system for treating a left atrial appendage
CN113925544A (en) * 2020-06-29 2022-01-14 上海微创医疗器械(集团)有限公司 Plugging device and preparation method thereof
US11812969B2 (en) 2020-12-03 2023-11-14 Coherex Medical, Inc. Medical device and system for occluding a tissue opening and method thereof

Citations (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2307480A (en) * 1941-07-08 1943-01-05 John L Ashe Telegraph key
US3123136A (en) * 1964-03-03 figures
US3166072A (en) * 1962-10-22 1965-01-19 Jr John T Sullivan Barbed clips
US3646615A (en) * 1970-01-26 1972-03-07 Richard A Ness Reinforcing element for muscles
US3716058A (en) * 1970-07-17 1973-02-13 Atlanta Res Inst Barbed suture
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3892232A (en) * 1973-09-24 1975-07-01 Alonzo J Neufeld Method and apparatus for performing percutaneous bone surgery
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4669473A (en) * 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4895148A (en) * 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US4924865A (en) * 1986-05-20 1990-05-15 Concept, Inc. Repair tack for bodily tissue
US4935028A (en) * 1987-01-12 1990-06-19 Drews Robert C Corneal rivet
US5013316A (en) * 1990-03-26 1991-05-07 Marlowe Goble E Soft tissue anchor system
US5021059A (en) * 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5085661A (en) * 1990-10-29 1992-02-04 Gerald Moss Surgical fastener implantation device
US5102421A (en) * 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5203864A (en) * 1991-04-05 1993-04-20 Phillips Edward H Surgical fastener system
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5380334A (en) * 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US5397331A (en) * 1991-11-25 1995-03-14 Cook Incorporated Supporting device and apparatus for inserting the device
US5400805A (en) * 1987-09-02 1995-03-28 American Cyanamid Company Surgical fastener
US5425744A (en) * 1991-11-05 1995-06-20 C. R. Bard, Inc. Occluder for repair of cardiac and vascular defects
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5505735A (en) * 1993-06-10 1996-04-09 Mitek Surgical Products, Inc. Surgical anchor and method for using the same
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US5620461A (en) * 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US5728116A (en) * 1994-01-13 1998-03-17 Ethicon, Inc. Spiral surgical tack
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US5860948A (en) * 1993-10-12 1999-01-19 Scimed Life Systems, Inc. Apparatus and method for tissue defect repair by deposition
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5893850A (en) * 1996-11-12 1999-04-13 Cachia; Victor V. Bone fixation device
US5902317A (en) * 1994-06-01 1999-05-11 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5904703A (en) * 1996-05-08 1999-05-18 Bard Connaught Occluder device formed from an open cell foam material
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US6059823A (en) * 1996-02-13 2000-05-09 Scimed Life Systems, Inc. Endovascular apparatus
US6077291A (en) * 1992-01-21 2000-06-20 Regents Of The University Of Minnesota Septal defect closure device
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6190400B1 (en) * 1991-10-22 2001-02-20 Kensey Nash Corporation Blood vessel sealing device and method of sealing an opening in a blood vessel
US6200336B1 (en) * 1998-06-02 2001-03-13 Cook Incorporated Multiple-sided intraluminal medical device
US6206895B1 (en) * 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US6210338B1 (en) * 1998-08-21 2001-04-03 Aga Medical Corp. Sizing catheter for measuring cardiovascular structures
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US6221092B1 (en) * 1998-03-30 2001-04-24 Nissho Corporation Closure device for transcatheter operations and catheter assembly therefor
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6231589B1 (en) * 1999-03-22 2001-05-15 Microvena Corporation Body vessel filter
US6238416B1 (en) * 1998-11-13 2001-05-29 Eleftherios B. Sideris Transcatheter surgical patch
US6241747B1 (en) * 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US6245079B1 (en) * 1995-08-24 2001-06-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
US6334864B1 (en) * 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US6342064B1 (en) * 1998-12-22 2002-01-29 Nipro Corporation Closure device for transcatheter operation and catheter assembly therefor
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US20020034537A1 (en) * 2000-05-03 2002-03-21 Brita Schulze Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
US6368339B1 (en) * 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US6375671B1 (en) * 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US20020055767A1 (en) * 2000-10-18 2002-05-09 Forde Sean T. Over-the-wire interlock attachment/detachment mechanism
US6391048B1 (en) * 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US20020068950A1 (en) * 1999-05-13 2002-06-06 Corcoran Michael P. Occlusion device with non-thrombogenic properties
US20030023262A1 (en) * 2001-07-18 2003-01-30 Jeffrey Welch Cardiac implant device tether system and method
US20030028213A1 (en) * 2001-08-01 2003-02-06 Microvena Corporation Tissue opening occluder
US20030045893A1 (en) * 2001-09-06 2003-03-06 Integrated Vascular Systems, Inc. Clip apparatus for closing septal defects and methods of use
US20030050665A1 (en) * 2001-09-07 2003-03-13 Integrated Vascular Systems, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US20030055455A1 (en) * 2001-09-20 2003-03-20 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US6537300B2 (en) * 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US6551343B1 (en) * 1998-04-01 2003-04-22 Bionx Implants, Oy Bioabsorbable surgical fastener for tissue treatment
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US20030093096A1 (en) * 1999-09-13 2003-05-15 Mcguckin James F. Vascular closure
US6569188B2 (en) * 1996-08-05 2003-05-27 Arthrex, Inc. Hex drive bioabsorbable tissue anchor
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6719777B2 (en) * 2000-12-07 2004-04-13 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US20040073242A1 (en) * 2002-06-05 2004-04-15 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US20040092973A1 (en) * 2002-09-23 2004-05-13 Nmt Medical, Inc. Septal puncture device
US20040098121A1 (en) * 2002-11-07 2004-05-20 Nmt Medical, Inc. Patent foramen ovale (PFO) closure with magnetic force
US20050033327A1 (en) * 1999-09-07 2005-02-10 John Gainor Retrievable septal defect closure device
US20050119675A1 (en) * 2003-10-24 2005-06-02 Adams Daniel O. Patent foramen ovale closure system

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015155A1 (en) 1990-04-02 1991-10-17 Kanji Inoue Device for closing shunt opening by nonoperative method
US5254133A (en) 1991-04-24 1993-10-19 Seid Arnold S Surgical implantation device and related method of use
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5258000A (en) 1991-11-25 1993-11-02 Cook Incorporated Tissue aperture repair device
DE4222291C1 (en) * 1992-07-07 1994-01-20 Krmek Mirko Prosthesis for closing atrial or ventricular-septal defect - comprises two equally shaped units of elastic sprung material with six radially running arms spaced apart by equal edges
GB2269321B (en) * 1992-08-05 1996-06-26 Nat Heart & Lung Inst Implantable occluder devices for medical use
US5342393A (en) 1992-08-27 1994-08-30 Duke University Method and device for vascular repair
WO1995028885A1 (en) 1994-04-22 1995-11-02 Sideris-Messini, Chrysoula Adjustable devices for the occlusion of cardiac defects
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US5433727A (en) 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5976174A (en) 1997-12-15 1999-11-02 Ruiz; Carlos E. Medical hole closure device and methods of use
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
CH693017A5 (en) * 1998-02-10 2003-01-31 Jump Jeffrey B surgical device occlusion defects.
WO2000069365A2 (en) * 1999-05-13 2000-11-23 St. Jude Medical Cardiovascular Group, Inc. Septal defect closure device

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123136A (en) * 1964-03-03 figures
US2307480A (en) * 1941-07-08 1943-01-05 John L Ashe Telegraph key
US3166072A (en) * 1962-10-22 1965-01-19 Jr John T Sullivan Barbed clips
US3646615A (en) * 1970-01-26 1972-03-07 Richard A Ness Reinforcing element for muscles
US3716058A (en) * 1970-07-17 1973-02-13 Atlanta Res Inst Barbed suture
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US3892232A (en) * 1973-09-24 1975-07-01 Alonzo J Neufeld Method and apparatus for performing percutaneous bone surgery
US4006747A (en) * 1975-04-23 1977-02-08 Ethicon, Inc. Surgical method
US4007743A (en) * 1975-10-20 1977-02-15 American Hospital Supply Corporation Opening mechanism for umbrella-like intravascular shunt defect closure device
US4669473A (en) * 1985-09-06 1987-06-02 Acufex Microsurgical, Inc. Surgical fastener
US4924865A (en) * 1986-05-20 1990-05-15 Concept, Inc. Repair tack for bodily tissue
US4895148A (en) * 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4935028A (en) * 1987-01-12 1990-06-19 Drews Robert C Corneal rivet
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US5400805A (en) * 1987-09-02 1995-03-28 American Cyanamid Company Surgical fastener
US4917089A (en) * 1988-08-29 1990-04-17 Sideris Eleftherios B Buttoned device for the transvenous occlusion of intracardiac defects
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5620461A (en) * 1989-05-29 1997-04-15 Muijs Van De Moer; Wouter M. Sealing device
US5013316A (en) * 1990-03-26 1991-05-07 Marlowe Goble E Soft tissue anchor system
US5021059A (en) * 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5102421A (en) * 1990-06-14 1992-04-07 Wm. E. Anpach, III Suture anchor and method of forming
US5085661A (en) * 1990-10-29 1992-02-04 Gerald Moss Surgical fastener implantation device
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5203864A (en) * 1991-04-05 1993-04-20 Phillips Edward H Surgical fastener system
US6190400B1 (en) * 1991-10-22 2001-02-20 Kensey Nash Corporation Blood vessel sealing device and method of sealing an opening in a blood vessel
US5425744A (en) * 1991-11-05 1995-06-20 C. R. Bard, Inc. Occluder for repair of cardiac and vascular defects
US5397331A (en) * 1991-11-25 1995-03-14 Cook Incorporated Supporting device and apparatus for inserting the device
US6077291A (en) * 1992-01-21 2000-06-20 Regents Of The University Of Minnesota Septal defect closure device
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5380334A (en) * 1993-02-17 1995-01-10 Smith & Nephew Dyonics, Inc. Soft tissue anchors and systems for implantation
US6079414A (en) * 1993-02-22 2000-06-27 Heartport, Inc. Method for thoracoscopic intracardiac procedures including septal defect
US5855614A (en) * 1993-02-22 1999-01-05 Heartport, Inc. Method and apparatus for thoracoscopic intracardiac procedures
US6346074B1 (en) * 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US6241747B1 (en) * 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US5505735A (en) * 1993-06-10 1996-04-09 Mitek Surgical Products, Inc. Surgical anchor and method for using the same
US5860948A (en) * 1993-10-12 1999-01-19 Scimed Life Systems, Inc. Apparatus and method for tissue defect repair by deposition
US5507811A (en) * 1993-11-26 1996-04-16 Nissho Corporation Prosthetic device for atrial septal defect repair
US5728116A (en) * 1994-01-13 1998-03-17 Ethicon, Inc. Spiral surgical tack
US5601571A (en) * 1994-05-17 1997-02-11 Moss; Gerald Surgical fastener implantation device
US5902317A (en) * 1994-06-01 1999-05-11 Nitinol Medical Technologies, Inc. Stent and method and apparatus for forming and delivering the same
US5725552A (en) * 1994-07-08 1998-03-10 Aga Medical Corporation Percutaneous catheter directed intravascular occlusion devices
US6368339B1 (en) * 1994-07-08 2002-04-09 Aga Medical Corporation Method of forming medical devices: intra-vascular occlusion devices
US6171329B1 (en) * 1994-12-19 2001-01-09 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US6245079B1 (en) * 1995-08-24 2001-06-12 Sutura, Inc. Suturing device and method for sealing an opening in a blood vessel or other biological structure
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US6355052B1 (en) * 1996-02-09 2002-03-12 Pfm Produkte Fur Die Medizin Aktiengesellschaft Device for closure of body defect openings
US6059823A (en) * 1996-02-13 2000-05-09 Scimed Life Systems, Inc. Endovascular apparatus
US5733294A (en) * 1996-02-28 1998-03-31 B. Braun Medical, Inc. Self expanding cardiovascular occlusion device, method of using and method of making the same
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US5904703A (en) * 1996-05-08 1999-05-18 Bard Connaught Occluder device formed from an open cell foam material
US6569188B2 (en) * 1996-08-05 2003-05-27 Arthrex, Inc. Hex drive bioabsorbable tissue anchor
US5741297A (en) * 1996-08-28 1998-04-21 Simon; Morris Daisy occluder and method for septal defect repair
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US6348053B1 (en) * 1996-11-12 2002-02-19 Triage Medical, Inc. Bone fixation device
US5893850A (en) * 1996-11-12 1999-04-13 Cachia; Victor V. Bone fixation device
US6080182A (en) * 1996-12-20 2000-06-27 Gore Enterprise Holdings, Inc. Self-expanding defect closure device and method of making and using
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6174322B1 (en) * 1997-08-08 2001-01-16 Cardia, Inc. Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum
US6221092B1 (en) * 1998-03-30 2001-04-24 Nissho Corporation Closure device for transcatheter operations and catheter assembly therefor
US6551343B1 (en) * 1998-04-01 2003-04-22 Bionx Implants, Oy Bioabsorbable surgical fastener for tissue treatment
US6200336B1 (en) * 1998-06-02 2001-03-13 Cook Incorporated Multiple-sided intraluminal medical device
US6210338B1 (en) * 1998-08-21 2001-04-03 Aga Medical Corp. Sizing catheter for measuring cardiovascular structures
US6238416B1 (en) * 1998-11-13 2001-05-29 Eleftherios B. Sideris Transcatheter surgical patch
US6342064B1 (en) * 1998-12-22 2002-01-29 Nipro Corporation Closure device for transcatheter operation and catheter assembly therefor
US6231589B1 (en) * 1999-03-22 2001-05-15 Microvena Corporation Body vessel filter
US6375671B1 (en) * 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6206907B1 (en) * 1999-05-07 2001-03-27 Cardia, Inc. Occlusion device with stranded wire support arms
US20020068950A1 (en) * 1999-05-13 2002-06-06 Corcoran Michael P. Occlusion device with non-thrombogenic properties
US6379368B1 (en) * 1999-05-13 2002-04-30 Cardia, Inc. Occlusion device with non-thrombogenic properties
US6712836B1 (en) * 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US6206895B1 (en) * 1999-07-13 2001-03-27 Scion Cardio-Vascular, Inc. Suture with toggle and delivery system
US6911037B2 (en) * 1999-09-07 2005-06-28 Ev3, Inc. Retrievable septal defect closure device
US7377936B2 (en) * 1999-09-07 2008-05-27 Ev3, Inc. Retrievable septal defect closure device
US20050033327A1 (en) * 1999-09-07 2005-02-10 John Gainor Retrievable septal defect closure device
US20030093096A1 (en) * 1999-09-13 2003-05-15 Mcguckin James F. Vascular closure
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6551303B1 (en) * 1999-10-27 2003-04-22 Atritech, Inc. Barrier device for ostium of left atrial appendage
US6391048B1 (en) * 2000-01-05 2002-05-21 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US6551344B2 (en) * 2000-04-26 2003-04-22 Ev3 Inc. Septal defect occluder
US6214029B1 (en) * 2000-04-26 2001-04-10 Microvena Corporation Septal defect occluder
US20020034537A1 (en) * 2000-05-03 2002-03-21 Brita Schulze Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
US6334864B1 (en) * 2000-05-17 2002-01-01 Aga Medical Corp. Alignment member for delivering a non-symmetric device with a predefined orientation
US20020055767A1 (en) * 2000-10-18 2002-05-09 Forde Sean T. Over-the-wire interlock attachment/detachment mechanism
US6719777B2 (en) * 2000-12-07 2004-04-13 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US6537300B2 (en) * 2001-05-30 2003-03-25 Scimed Life Systems, Inc. Implantable obstruction device for septal defects
US20030023262A1 (en) * 2001-07-18 2003-01-30 Jeffrey Welch Cardiac implant device tether system and method
US20070106327A1 (en) * 2001-08-01 2007-05-10 Ev3 Endovascular, Inc. Tissue opening occluder
US20030028213A1 (en) * 2001-08-01 2003-02-06 Microvena Corporation Tissue opening occluder
US20080058866A1 (en) * 2001-08-01 2008-03-06 Young Michelle M Tissue opening occluder
US20070112382A1 (en) * 2001-08-01 2007-05-17 Microvena Corporation Tissue opening occluder
US20030045893A1 (en) * 2001-09-06 2003-03-06 Integrated Vascular Systems, Inc. Clip apparatus for closing septal defects and methods of use
US20030050665A1 (en) * 2001-09-07 2003-03-13 Integrated Vascular Systems, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US20030055455A1 (en) * 2001-09-20 2003-03-20 Scimed Life Systems, Inc. Method and apparatus for treating septal defects
US20040073242A1 (en) * 2002-06-05 2004-04-15 Nmt Medical, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US20040092973A1 (en) * 2002-09-23 2004-05-13 Nmt Medical, Inc. Septal puncture device
US20040098121A1 (en) * 2002-11-07 2004-05-20 Nmt Medical, Inc. Patent foramen ovale (PFO) closure with magnetic force
US20050119675A1 (en) * 2003-10-24 2005-06-02 Adams Daniel O. Patent foramen ovale closure system

Cited By (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8808329B2 (en) 1998-02-06 2014-08-19 Bonutti Skeletal Innovations Llc Apparatus and method for securing a portion of a body
US20040010287A1 (en) * 1999-08-09 2004-01-15 Bonutti Peter M. Method and apparatus for securing tissue
US8845699B2 (en) 1999-08-09 2014-09-30 Bonutti Skeletal Innovations Llc Method of securing tissue
US9884451B2 (en) 2000-03-13 2018-02-06 P Tech, Llc Method of using ultrasonic vibration to secure body tissue
US9067362B2 (en) 2000-03-13 2015-06-30 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US9986994B2 (en) 2000-03-13 2018-06-05 P Tech, Llc Method and device for securing body tissue
US8747439B2 (en) 2000-03-13 2014-06-10 P Tech, Llc Method of using ultrasonic vibration to secure body tissue with fastening element
US8814902B2 (en) 2000-05-03 2014-08-26 Bonutti Skeletal Innovations Llc Method of securing body tissue
US20020198563A1 (en) * 2000-07-28 2002-12-26 Microvena Corporation Defect occluder release assembly & method
US9078630B2 (en) 2001-06-01 2015-07-14 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US8777985B2 (en) 2001-06-01 2014-07-15 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US7717937B2 (en) 2001-06-01 2010-05-18 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US20070112382A1 (en) * 2001-08-01 2007-05-17 Microvena Corporation Tissue opening occluder
US7887562B2 (en) 2001-08-01 2011-02-15 Ev3 Endovascular, Inc. Tissue opening occluder
US7678132B2 (en) 2001-09-06 2010-03-16 Ovalis, Inc. Systems and methods for treating septal defects
US8758401B2 (en) 2001-09-06 2014-06-24 ProMed, Inc. Systems and methods for treating septal defects
US7740640B2 (en) 2001-09-06 2010-06-22 Ovalis, Inc. Clip apparatus for closing septal defects and methods of use
US7686828B2 (en) 2001-09-06 2010-03-30 Ovalis, Inc. Systems and methods for treating septal defects
US8070826B2 (en) 2001-09-07 2011-12-06 Ovalis, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US8747483B2 (en) 2001-09-07 2014-06-10 ProMed, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
US9770238B2 (en) 2001-12-03 2017-09-26 P Tech, Llc Magnetic positioning apparatus
US7867250B2 (en) 2001-12-19 2011-01-11 Nmt Medical, Inc. Septal occluder and associated methods
US7967840B2 (en) 2001-12-19 2011-06-28 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US8758403B2 (en) 2001-12-19 2014-06-24 W.L. Gore & Associates, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US10368953B2 (en) 2002-03-20 2019-08-06 P Tech, Llc Robotic system for fastening layers of body tissue together and method thereof
US9192395B2 (en) 2002-03-20 2015-11-24 P Tech, Llc Robotic fastening system
US9629687B2 (en) 2002-03-20 2017-04-25 P Tech, Llc Robotic arthroplasty system
US9877793B2 (en) 2002-03-20 2018-01-30 P Tech, Llc Robotic arthroplasty system
US9149281B2 (en) 2002-03-20 2015-10-06 P Tech, Llc Robotic system for engaging a fastener with body tissue
US10869728B2 (en) 2002-03-20 2020-12-22 P Tech, Llc Robotic surgery
US9271741B2 (en) 2002-03-20 2016-03-01 P Tech, Llc Robotic ultrasonic energy system
US10959791B2 (en) 2002-03-20 2021-03-30 P Tech, Llc Robotic surgery
US9585725B2 (en) 2002-03-20 2017-03-07 P Tech, Llc Robotic arthroplasty system
US9808318B2 (en) 2002-03-20 2017-11-07 P Tech, Llc Robotic arthroplasty system
US10932869B2 (en) 2002-03-20 2021-03-02 P Tech, Llc Robotic surgery
US9486227B2 (en) 2002-03-20 2016-11-08 P Tech, Llc Robotic retractor system
US10265128B2 (en) 2002-03-20 2019-04-23 P Tech, Llc Methods of using a robotic spine system
US9271779B2 (en) 2002-03-20 2016-03-01 P Tech, Llc Methods of using a robotic spine system
US9155544B2 (en) 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
US9241695B2 (en) 2002-03-25 2016-01-26 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure clips
US7976564B2 (en) 2002-05-06 2011-07-12 St. Jude Medical, Cardiology Division, Inc. PFO closure devices and related methods of use
US20060036284A1 (en) * 2002-05-06 2006-02-16 Velocimed, Llc PFO closure devices and related methods of use
US7691128B2 (en) 2002-05-06 2010-04-06 St. Jude Medical, Cardiology Division, Inc. PFO closure devices and related methods of use
US9216014B2 (en) 2002-06-03 2015-12-22 W.L. Gore & Associates, Inc. Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof
US9028527B2 (en) 2002-06-05 2015-05-12 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US8784448B2 (en) 2002-06-05 2014-07-22 W.L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with radial and circumferential support
US9750496B2 (en) 2002-08-27 2017-09-05 P Tech, Llc System for securing a portion of a body
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
US7445623B2 (en) * 2002-11-15 2008-11-04 Claude Mialhe Occlusive device for medical or surgical use
US20060052804A1 (en) * 2002-11-15 2006-03-09 Claude Mialhe Occlusive device for medical or surgical use
US9017373B2 (en) 2002-12-09 2015-04-28 W.L. Gore & Associates, Inc. Septal closure devices
US7780700B2 (en) 2003-02-04 2010-08-24 ev3 Endovascular, Inc Patent foramen ovale closure system
US7658747B2 (en) 2003-03-12 2010-02-09 Nmt Medical, Inc. Medical device for manipulation of a medical implant
US20040181256A1 (en) * 2003-03-14 2004-09-16 Glaser Erik N. Collet-based delivery system
US20070016250A1 (en) * 2003-04-11 2007-01-18 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US8574264B2 (en) 2003-04-11 2013-11-05 St. Jude Medical, Cardiology Division, Inc. Method for retrieving a closure device
US8372112B2 (en) 2003-04-11 2013-02-12 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods, and related methods of use
US8382796B2 (en) 2003-04-11 2013-02-26 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and related methods of use
US9060767B2 (en) 2003-04-30 2015-06-23 P Tech, Llc Tissue fastener and methods for using same
US9962162B2 (en) 2003-04-30 2018-05-08 P Tech, Llc Tissue fastener and methods for using same
US8758395B2 (en) 2003-05-19 2014-06-24 Septrx, Inc. Embolic filtering method and apparatus
US7648532B2 (en) 2003-05-19 2010-01-19 Septrx, Inc. Tissue distention device and related methods for therapeutic intervention
US11375988B2 (en) 2003-07-14 2022-07-05 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US9149263B2 (en) 2003-07-14 2015-10-06 W. L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9326759B2 (en) 2003-07-14 2016-05-03 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US7678123B2 (en) 2003-07-14 2010-03-16 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US7963952B2 (en) 2003-08-19 2011-06-21 Wright Jr John A Expandable sheath tubing
US7691112B2 (en) 2003-09-11 2010-04-06 Nmt Medical, Inc. Devices, systems, and methods for suturing tissue
US20050119675A1 (en) * 2003-10-24 2005-06-02 Adams Daniel O. Patent foramen ovale closure system
US8992556B2 (en) 2003-11-06 2015-03-31 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US7666203B2 (en) 2003-11-06 2010-02-23 Nmt Medical, Inc. Transseptal puncture apparatus
US8292910B2 (en) 2003-11-06 2012-10-23 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US8157829B2 (en) 2003-11-06 2012-04-17 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US8753362B2 (en) 2003-12-09 2014-06-17 W.L. Gore & Associates, Inc. Double spiral patent foramen ovale closure clamp
US7988690B2 (en) 2004-01-30 2011-08-02 W.L. Gore & Associates, Inc. Welding systems useful for closure of cardiac openings
US8262694B2 (en) 2004-01-30 2012-09-11 W.L. Gore & Associates, Inc. Devices, systems, and methods for closure of cardiac openings
US8361111B2 (en) 2004-01-30 2013-01-29 W.L. Gore & Associates, Inc. Devices, systems and methods for closure of cardiac openings
US8568431B2 (en) 2004-03-03 2013-10-29 W.L. Gore & Associates, Inc. Delivery/recovery system for septal occluder
US7871419B2 (en) 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US8945158B2 (en) 2004-03-03 2015-02-03 W.L. Gore & Associates, Inc. Delivery/recovery system for septal occluder
US9888916B2 (en) 2004-03-09 2018-02-13 P Tech, Llc Method and device for securing body tissue
US8828049B2 (en) 2004-04-09 2014-09-09 W.L. Gore & Associates, Inc. Split ends closure device and methods of use
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US8568447B2 (en) 2004-05-06 2013-10-29 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US9545247B2 (en) 2004-05-07 2017-01-17 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
US8257389B2 (en) 2004-05-07 2012-09-04 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
US8480709B2 (en) 2004-05-07 2013-07-09 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
US7704268B2 (en) 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
US8764848B2 (en) 2004-09-24 2014-07-01 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US9814453B2 (en) 2004-10-26 2017-11-14 P Tech, Llc Deformable fastener system
US10238378B2 (en) 2004-10-26 2019-03-26 P Tech, Llc Tissue fixation system and method
US9579129B2 (en) 2004-10-26 2017-02-28 P Tech, Llc Devices and methods for stabilizing tissue and implants
US11457958B2 (en) 2004-10-26 2022-10-04 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9545268B2 (en) 2004-10-26 2017-01-17 P Tech, Llc Devices and methods for stabilizing tissue and implants
US11013542B2 (en) 2004-10-26 2021-05-25 P Tech, Llc Tissue fixation system and method
US9999449B2 (en) 2004-10-26 2018-06-19 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US10813764B2 (en) 2004-10-26 2020-10-27 P Tech, Llc Expandable introducer system and methods
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9867706B2 (en) 2004-10-26 2018-01-16 P Tech, Llc Tissue fastening system
US9226828B2 (en) 2004-10-26 2016-01-05 P Tech, Llc Devices and methods for stabilizing tissue and implants
US20060229623A1 (en) * 2004-10-26 2006-10-12 Bonutti Peter M Tissue fixation system and method
US9980761B2 (en) 2004-10-26 2018-05-29 P Tech, Llc Tissue fixation system and method
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9980717B2 (en) 2005-02-22 2018-05-29 P Tech, Llc Device and method for securing body tissue
US20060200199A1 (en) * 2005-02-22 2006-09-07 Bonutti Peter M Device and method for securing body tissue
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US20060241687A1 (en) * 2005-03-16 2006-10-26 Glaser Erik N Septal occluder with pivot arms and articulating joints
US20060217760A1 (en) * 2005-03-17 2006-09-28 Widomski David R Multi-strand septal occluder
US8430907B2 (en) 2005-03-18 2013-04-30 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8636765B2 (en) 2005-03-18 2014-01-28 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8372113B2 (en) 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
US20090082804A1 (en) * 2005-03-29 2009-03-26 Terumo Kabushiki Kaisha Defect-Closure Device and Delivery Apparatus
US8777983B2 (en) 2005-03-29 2014-07-15 Terumo Kabushiki Kaisha Defect-closure device and delivery apparatus
US7321798B2 (en) 2005-03-31 2008-01-22 Medtronic, Inc. Trans-septal/trans-myocardial ventricular pacing lead
US20060224224A1 (en) * 2005-03-31 2006-10-05 Lambert Muhlenberg Trans-septal/trans-myocardial ventricular pacing lead
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US8795329B2 (en) 2005-09-06 2014-08-05 W.L. Gore & Associates, Inc. Removable intracardiac RF device
US10368942B2 (en) 2005-09-06 2019-08-06 W. L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US7797056B2 (en) 2005-09-06 2010-09-14 Nmt Medical, Inc. Removable intracardiac RF device
US10376259B2 (en) 2005-10-05 2019-08-13 P Tech, Llc Deformable fastener system
US10441269B1 (en) 2005-10-05 2019-10-15 P Tech, Llc Deformable fastener system
US11219446B2 (en) 2005-10-05 2022-01-11 P Tech, Llc Deformable fastener system
US9084603B2 (en) 2005-12-22 2015-07-21 W.L. Gore & Associates, Inc. Catch members for occluder devices
US9439642B2 (en) 2006-02-07 2016-09-13 P Tech, Llc Methods and devices for utilizing bondable materials
US11134995B2 (en) 2006-02-07 2021-10-05 P Tech, Llc Method and devices for intracorporeal bonding of implants with thermal energy
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US9421005B2 (en) 2006-02-07 2016-08-23 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US9173650B2 (en) 2006-02-07 2015-11-03 P Tech, Llc Methods and devices for trauma welding
US9610073B2 (en) 2006-02-07 2017-04-04 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US10368924B2 (en) 2006-02-07 2019-08-06 P Tech, Llc Methods and devices for trauma welding
US11129645B2 (en) 2006-02-07 2021-09-28 P Tech, Llc Methods of securing a fastener
US9743963B2 (en) 2006-02-07 2017-08-29 P Tech, Llc Methods and devices for trauma welding
US8814947B2 (en) 2006-03-31 2014-08-26 W.L. Gore & Associates, Inc. Deformable flap catch mechanism for occluder device
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US20070244494A1 (en) * 2006-04-18 2007-10-18 Downing Stephen W Methods and devices for treating atrial septal defects
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
JP2009536550A (en) * 2006-05-10 2009-10-15 ミネソタ メディカル ディベロップメント、インコーポレイテッド Hernia patch production method and resulting product
US20080009888A1 (en) * 2006-07-07 2008-01-10 Usgi Medical, Inc. Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US8870916B2 (en) * 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US9402668B2 (en) 2007-02-13 2016-08-02 P Tech, Llc Tissue fixation system and method
US10517584B1 (en) 2007-02-13 2019-12-31 P Tech, Llc Tissue fixation system and method
US11801044B2 (en) 2007-02-13 2023-10-31 P Tech, Llc Tissue fixation system and method
US10390817B2 (en) 2007-02-13 2019-08-27 P Tech, Llc Tissue fixation system and method
US9949728B2 (en) 2007-04-05 2018-04-24 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US9005242B2 (en) 2007-04-05 2015-04-14 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US10485525B2 (en) 2007-04-05 2019-11-26 W.L. Gore & Associates, Inc. Septal closure device with centering mechanism
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US10278705B2 (en) 2008-03-07 2019-05-07 W. L. Gore & Associates, Inc. Heart occlusion devices
US9474517B2 (en) 2008-03-07 2016-10-25 W. L. Gore & Associates, Inc. Heart occlusion devices
US8277482B2 (en) 2009-03-16 2012-10-02 Cook Medical Technologies Llc Closure device with string retractable umbrella and method for closing a body opening with the same
US20100234878A1 (en) * 2009-03-16 2010-09-16 Cook Incorporated Closure device with string retractable umbrella
US8029534B2 (en) * 2009-03-16 2011-10-04 Cook Medical Technologies Llc Closure device with string retractable umbrella
US10806437B2 (en) 2009-06-22 2020-10-20 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11596391B2 (en) 2009-06-22 2023-03-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10792025B2 (en) 2009-06-22 2020-10-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11589853B2 (en) 2009-06-22 2023-02-28 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11564672B2 (en) 2009-06-22 2023-01-31 W. L. Gore & Associates, Inc. Sealing device and delivery system
US8828051B2 (en) 2010-07-02 2014-09-09 Pfm Medical Ag Left atrial appendage occlusion device
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US11844913B2 (en) 2012-03-23 2023-12-19 Boston Scientific Medical Device Limited Transseptal puncture apparatus and method for using the same
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US11771408B2 (en) 2013-01-18 2023-10-03 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20140364872A1 (en) * 2013-06-05 2014-12-11 Lc Therapeutics, Inc. Tissue anchor and deployment device for same
US11298116B2 (en) 2014-06-06 2022-04-12 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US10368853B2 (en) 2014-06-06 2019-08-06 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11317974B2 (en) 2015-10-21 2022-05-03 P Tech, Llc Systems and methods for navigation and visualization
US11684430B2 (en) 2015-10-21 2023-06-27 P Tech, Llc Systems and methods for navigation and visualization
US11744651B2 (en) 2015-10-21 2023-09-05 P Tech, Llc Systems and methods for navigation and visualization
US10765484B2 (en) 2015-10-21 2020-09-08 P Tech, Llc Systems and methods for navigation and visualization
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
CN110049792A (en) * 2016-11-23 2019-07-23 马真塔医药有限公司 Blood pump

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EP1222897A2 (en) 2002-07-17
US20010037129A1 (en) 2001-11-01
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DE60239647D1 (en) 2011-05-12
EP1222897A3 (en) 2004-01-02

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