US20040037877A1 - Flavored gelatin capsule and method of manufacture - Google Patents
Flavored gelatin capsule and method of manufacture Download PDFInfo
- Publication number
- US20040037877A1 US20040037877A1 US10/646,898 US64689803A US2004037877A1 US 20040037877 A1 US20040037877 A1 US 20040037877A1 US 64689803 A US64689803 A US 64689803A US 2004037877 A1 US2004037877 A1 US 2004037877A1
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- Prior art keywords
- capsule
- fish oil
- dose
- flavored
- water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Definitions
- This invention relates to capsule formulations, medicinal and nutritive dose encapsulations and methods of manufacture of capsules. More specifically, the invention introduces flavoring into the manufacture of capsules and encapsulated doses.
- Conventional Art The taste of many medicinal and nutritive components can be quite distinctive and potentially unpleasant. Improvements in the taste of certain drugs and nutritional supplements can lead to a higher compliance by consumers. A higher compliance will result in greater commercial success for the drug and supplement manufacture and in increased health and well being particular consumers.
- composition of certain fish oils includes elements that are identified in medical literature as providing significant health benefits.
- Polyunsaturated fatty acids to include long chain Omega 3 fatty acids such as eicosapentenoic acid (EPA) and docosahexenoic acid (DHA) are present in the livers of lean fish and other tissues of EPA.
- EPA eicosapentenoic acid
- DHA docosahexenoic acid
- DHA may also decrease blood levels of TG lipids, increases blood levels of high density lipids (HDL). Furthermore, DHA might lower blood pressure, attack early phases of inflammation, facilitate the growth, development and function of the central nervous system and improves the clinical symptoms of depression and schizophrenia.
- a flavored gelatin capsule comprising a water soluble flavor.
- the flavored gelatin capsule may include about 10 to about 70 parts by weight of a gelatin, about 10 to about 35 parts by weight of a glycerol, about 8 to about 35 parts by weight of a moisturizer and about 1 parts by weight of the water soluble flavoring.
- the flavoring of the capsule improves the taste and palatability of the capsule and will subjectively improve the taste of the gelatin and a dose or contents contained within the flavored gelatin capsule to individual consumers or patients.
- the flavor may be one of, or a combination of suitable flavors known in the art, to include berry, strawberry, chocolate, cocoa, vanilla, lemon, nut, almond, cashew, macadamia nut, coconut, blueberry, blackberry, raspberry, peach, lemon, lime, mint, peppermint, orange, banana, chili pepper, pepper, cinnamon, and pineapple.
- the gelatin capsule composition may include a polyol, such as sorbitol, glycerol or other suitable softening agent known in the art.
- a preferred embodiment of the present invention includes flavoring the contents of the gelatin capsule in addition to flavoring the gelatin capsule.
- an oil soluble flavoring may be optionally mixed with a fish oil that is encapsulated within the capsule.
- the oil soluble flavoring may be similar to the taste of the flavor of the capsule, e.g., strawberry and strawberry, or the taste of the oil flavoring may be complementary to the capsule flavoring, e.g., banana and strawberry.
- Fish oil containing Omega 3 fatty acids such as eicosapentenoic acid (EPA) and docosahexenoic acid (DHA) are one appropriate subject of inclusion into certain preferred embodiments of the present invention.
- the capsule of these certain preferred embodiments is flavored and the fish oil may optionally be flavored.
- the method of the present invention includes the manufacturing process steps of combining gelatin, a glycerol or a polyol like sorbitol as a softener, water or a moisturizer containing water, a flavoring agent and optionally a coloring agent such as a titanium oxide, keratin or other suitable coloring agent known in the art.
- Modified vegetable starch is substituted for gelatin in certain preferred embodiments of the present invention.
- the gelatin may be a suitable mammalian or fish gelatin known in the art.
- the suitable gelatin or vegetable starch selected is used as a principal forming agent of the capsule.
- FIG. 1 is a flavored gelatin capsule containing a fish oil dose.
- FIG. 2 is manufacturing process flow chart illustrating an embodiment of the method of the present invention.
- an encapsulated composition of a gelatin capsule and fish oil 2 , or fish oil capsule 2 is formed by the encapsulation of a dose of fish oil 6 by a gelatin capsule 4 .
- the gelatin capsule 4 is made of gelatin, glycerol water, a flavoring and optionally a coloring agent.
- the fish oil dose 6 includes 180 mg of EPA and 120 mg of DHA.
- the manufacturing process of the preferred embodiment 2 of includes the steps of combining gelswatch ingredients, melting and forming a liquefied gelswatch, delivering the liquefied gelswatch and the fish oil 6 to an encapsulation machine, encapsulating a dose of fish oil, drying the encapsulated dose, washing the encapsulated dose and packaging the fish oil capsules 2 for shipment.
- the gelswatch ingredients may include gelatin or a gelatin substitute such as modified starch or other suitable gelatin substitute known in the art, a softener such as glycerol or sorbitol or other suitable polyol or other gelatin softener known in the art, a flavoring agent such as strawberry flavor Firmenich #52311A or other suitable gelatin capsule flavoring known in the art and optionally a coloring agent such as keratin or other suitable gelatin capsule coloring agent known in the art.
- gelatin or a gelatin substitute such as modified starch or other suitable gelatin substitute known in the art
- a softener such as glycerol or sorbitol or other suitable polyol or other gelatin softener known in the art
- a flavoring agent such as strawberry flavor Firmenich #52311A or other suitable gelatin capsule flavoring known in the art
- a coloring agent such as keratin or other suitable gelatin capsule coloring agent known in the art.
- the preferred embodiment 2 may be formed from a gelswatch mixture of 45 parts by weight of gelatin, 20 parts by weight of glycerol 35 parts by weight of water and 0.5 or more parts by weight of strawberry flavor Firmenich #52311A.
- the gelswatch ingredients are then heated to about 60 degrees to 70 degrees Celsius and mixed together.
- the capsule is made of the gelswatch material.
- the liquefied gelswatch and the fish oil 6 is then poured into an encapsulation machine. The encapsulation machine then
- [0028] forms the fish oil capsule 2 comprising the fish oil dose 6 encapsulated by the gelatin capsule 4 .
- the range of water parts initially combined with the gelswatch may range from about 10 parts by weight to about 45 parts by weight; the amount of gelatin initially combined into the gelswatch may range from 10 parts by weight to about 70 parts by weight; and the amount of glycerol or other suitable softener known in the art may range from about 10 parts by weight to about 35 parts by weight.
- the capsule composition 2 comprises about 500 milligrams of the fish oil dose 6 and about 240 milligrams of capsule 4 as formed from the gelswatch.
- the fish oil capsule composition 2 is then dried at a temperature of about 20 degrees Celsius.
- the water content of the gelatin capsule is reduced to about 8%+/ ⁇ 2% by evaporation during the drying process step.
- the capsule 2 is then washed and packaged for shipment.
- Certain preferred embodiments comprise fish oil presenting concentrations of Omega 3 fish as high or higher than 80% of the total weight of the dose 6 , wherein the fish oil may include 50% DHA of the total weight of the dose 6, 20% EPA of the total weight of the dose 6 and about 10% by weight of other Omega 3 compounds.
- the concentration levels of the flavoring additive of a fish oil dose may, in certain preferred embodiments of the present invention having about 80% by weight of Omega 3 components, is reduced to from about 0.25% by weight to about 0.50% by weight of the dose 6
Abstract
A flavored capsule and the method of manufacture of the flavored capsule is provided. The capsule may comprise (a) from about 10 to about 70 parts by weight of gelatin; (b) from about 10 to about 35 parts by weight of a suitable polyol, such as glycerol; (c) from about 8 parts by weight of water; and (c) various parts by weight of particular water soluble flavorings. The contents of the capsule may also be flavored. The composition is particularly useful in improving the palatability of fish oil medicinal.
Description
- This application is a continuation of application Ser. No. 10/292,999 filed on Nov. 12, 2002, the entire contents of which are incorporated herein by reference, which is a continuation of application Ser. No. 10/041,877 filed on Oct. 22, 2001, which is a continuation of application Ser. No. 09/416,017 filed on Oct. 6, 1999 which is now U.S. Pat. No. 6,346,231.
- 1. Field of the Invention
- This invention relates to capsule formulations, medicinal and nutritive dose encapsulations and methods of manufacture of capsules. More specifically, the invention introduces flavoring into the manufacture of capsules and encapsulated doses. 2. Conventional Art The taste of many medicinal and nutritive components can be quite distinctive and potentially unpleasant. Improvements in the taste of certain drugs and nutritional supplements can lead to a higher compliance by consumers. A higher compliance will result in greater commercial success for the drug and supplement manufacture and in increased health and well being particular consumers.
- Taste is both a matter of purely subjective preference. Yet human taste is also strongly influenced by experience and cultural impressions. Broad generalizations about consumer taste presence can thus sometimes be relied upon in predicting market acceptance of specific drug and nutritive formulations. In Norway, for example the tastes of fish oils are far more palatable than in the United States. As a consequence of this United States market aversion to the taste of fish oils, many residents of the United States are less willing to ingest fish oils and will therefore not benefit from the nutritional and medicinal qualities of fish oils.
- Yet the composition of certain fish oils includes elements that are identified in medical literature as providing significant health benefits. Polyunsaturated fatty acids, to include long chain Omega 3 fatty acids such as eicosapentenoic acid (EPA) and docosahexenoic acid (DHA) are present in the livers of lean fish and other tissues of
- fatty fish. The human body cannot synthesize these fatty acids nor can it derive them from other fatty acids. As these fatty acids provide both medicinal and nutritional benefits, an intake of up two grams per day has been recommended by certain medical authorities.
- It is suspected that Eicosanoids derived from EPA might have an anti-inflammatory effect on humans. It has been suggested that EPA might decrease blood levels of TG lipids, increase blood levels of high density lipids (HDL), decrease blood clotting, reduce the incidence of cardiac arrhythmia and stabilize heart rhythm.
- It has been suggested that DHA may also decrease blood levels of TG lipids, increases blood levels of high density lipids (HDL). Furthermore, DHA might lower blood pressure, attack early phases of inflammation, facilitate the growth, development and function of the central nervous system and improves the clinical symptoms of depression and schizophrenia.
- Increasing the consumption of recommended doses of certain Omega-3 fatty acids might therefore have a medically and nutritionally beneficial affect on many consumers and patients. Yet conventional techniques to improve the palatability of fish oils and other subjectively harsh tasting substances are limited in the prior art to the addition of flavorings into a mixture of the substances themselves. The flavoring of capsules of encapsulated formulations has been absent in the conventional art.
- It is therefore an object of the present invention to provide a method of manufacture of gelatin capsules.
- It is another object of the present invention to provide a gelatin capsule comprising a flavor.
- It is an additional object of the present invention to optionally provide a flavored gelatin capsule containing a fish oil.
- It is an yet another object of the present invention to optionally provide a flavored gelatin capsule containing a flavored fish oil.
- These and other objects and advantages of the present invention are achieved by providing a flavored gelatin capsule comprising a water soluble flavor. The flavored gelatin capsule may include about 10 to about 70 parts by weight of a gelatin, about 10 to about 35 parts by weight of a glycerol, about 8 to about 35 parts by weight of a moisturizer and about 1 parts by weight of the water soluble flavoring. The flavoring of the capsule improves the taste and palatability of the capsule and will subjectively improve the taste of the gelatin and a dose or contents contained within the flavored gelatin capsule to individual consumers or patients.
- The flavor may be one of, or a combination of suitable flavors known in the art, to include berry, strawberry, chocolate, cocoa, vanilla, lemon, nut, almond, cashew, macadamia nut, coconut, blueberry, blackberry, raspberry, peach, lemon, lime, mint, peppermint, orange, banana, chili pepper, pepper, cinnamon, and pineapple.
- The gelatin capsule composition may include a polyol, such as sorbitol, glycerol or other suitable softening agent known in the art.
- A preferred embodiment of the present invention includes flavoring the contents of the gelatin capsule in addition to flavoring the gelatin capsule. In particular, an oil soluble flavoring may be optionally mixed with a fish oil that is encapsulated within the capsule. The oil soluble flavoring may be similar to the taste of the flavor of the capsule, e.g., strawberry and strawberry, or the taste of the oil flavoring may be complementary to the capsule flavoring, e.g., banana and strawberry.
- Fish oil containing Omega 3 fatty acids such as eicosapentenoic acid (EPA) and docosahexenoic acid (DHA) are one appropriate subject of inclusion into certain preferred embodiments of the present invention. The capsule of these certain preferred embodiments is flavored and the fish oil may optionally be flavored.
- The method of the present invention includes the manufacturing process steps of combining gelatin, a glycerol or a polyol like sorbitol as a softener, water or a moisturizer containing water, a flavoring agent and optionally a coloring agent such as a titanium oxide, keratin or other suitable coloring agent known in the art.
- Modified vegetable starch is substituted for gelatin in certain preferred embodiments of the present invention. Where gelatin is used, the gelatin may be a suitable mammalian or fish gelatin known in the art. The suitable gelatin or vegetable starch selected is used as a principal forming agent of the capsule.
- FIG. 1 is a flavored gelatin capsule containing a fish oil dose.
- FIG. 2 is manufacturing process flow chart illustrating an embodiment of the method of the present invention.
- In describing the preferred embodiments, certain terminology will be utilized for the sake of clarity. Such terminology is intended to encompass the recited embodiment, as well as all technical equivalents which operate in a similar manner for a similar purpose to achieve a similar result.
- Referring now to FIG. 1, an encapsulated composition of a gelatin capsule and
fish oil 2, orfish oil capsule 2, is formed by the encapsulation of a dose offish oil 6 by agelatin capsule 4. Thegelatin capsule 4 is made of gelatin, glycerol water, a flavoring and optionally a coloring agent. Thefish oil dose 6 includes 180 mg of EPA and 120 mg of DHA. - Referring now to FIGS. 1 and 2, the manufacturing process of the
preferred embodiment 2 of includes the steps of combining gelswatch ingredients, melting and forming a liquefied gelswatch, delivering the liquefied gelswatch and thefish oil 6 to an encapsulation machine, encapsulating a dose of fish oil, drying the encapsulated dose, washing the encapsulated dose and packaging thefish oil capsules 2 for shipment. - The gelswatch ingredients may include gelatin or a gelatin substitute such as modified starch or other suitable gelatin substitute known in the art, a softener such as glycerol or sorbitol or other suitable polyol or other gelatin softener known in the art, a flavoring agent such as strawberry flavor Firmenich #52311A or other suitable gelatin capsule flavoring known in the art and optionally a coloring agent such as keratin or other suitable gelatin capsule coloring agent known in the art.
- The
preferred embodiment 2 may be formed from a gelswatch mixture of 45 parts by weight of gelatin, 20 parts by weight of glycerol 35 parts by weight of water and 0.5 or more parts by weight of strawberry flavor Firmenich #52311A. The gelswatch ingredients are then heated to about 60 degrees to 70 degrees Celsius and mixed together. The capsule is made of the gelswatch material. The liquefied gelswatch and thefish oil 6 is then poured into an encapsulation machine. The encapsulation machine then - forms the
fish oil capsule 2 comprising thefish oil dose 6 encapsulated by thegelatin capsule 4. - In certain alternate preferred embodiments of the present invention the range of water parts initially combined with the gelswatch may range from about 10 parts by weight to about 45 parts by weight; the amount of gelatin initially combined into the gelswatch may range from 10 parts by weight to about 70 parts by weight; and the amount of glycerol or other suitable softener known in the art may range from about 10 parts by weight to about 35 parts by weight.
- The
capsule composition 2 comprises about 500 milligrams of thefish oil dose 6 and about 240 milligrams ofcapsule 4 as formed from the gelswatch. - The fish
oil capsule composition 2 is then dried at a temperature of about 20 degrees Celsius. The water content of the gelatin capsule is reduced to about 8%+/−2% by evaporation during the drying process step. Thecapsule 2 is then washed and packaged for shipment. - Experimental testing of the effects of varying amounts of the flavoring in both the
capsule 4 and thefish oil 6 has shown that a concentration of 0.5% in thefish oil 6 of the Firmenlch #52311A flavor will degrade in less than a year's span to below a desirable level of potency to the average North American consumer. Levels of 1 part by weight are preferred in order to extend the effective shelf life of thecomposition 2 beyond one year. - In addition, stream of commerce testing of concentration levels of Firmenich #52311 A has shown that a level in excess of about 1.0 part by weight of the Firmenich #52311A in the
capsule 4 provides an unexpected increase in the palatability of thecomposition 2 by generating a flavored bouquet from thecapsules 2, whereby the consumer is greatly encouraged to ingest thecomposition 4 in a favorable response to his or her olfactory appreciation of the bouquet. - Certain preferred embodiments comprise fish oil presenting concentrations of Omega 3 fish as high or higher than 80% of the total weight of the
dose 6, wherein the fish oil may include 50% DHA of the total weight of thedose 6, 20% EPA of the total weight of thedose 6 and about 10% by weight of other Omega 3 compounds. The concentration levels of the flavoring additive of a fish oil dose may, in certain preferred embodiments of the present invention having about 80% by weight of Omega 3 components, is reduced to from about 0.25% by weight to about 0.50% by weight of thedose 6 - Those skilled in the art will appreciate that various adaptations and modifications of the just-described preferred embodiments can be configured without departing from the scope and spirit of the invention. Therefore, it is to be understood that, within the scope of the appended claims, the invention may be practiced other than as specifically described herein.
Claims (13)
1. A flavored capsule suitable for encapsulating a dose of fish oil comprising:
a) a forming agent chosen from the group consisting of gelatin and vegetable starch;
b) a capsule softener;
c) water; and
d) a water soluble flavoring, wherein said capsule softener is present in a concentration in the range of about 10% to about 35%, water is present in the range of about 6% to about 10%, and the water soluble flavoring is present in a quantity which improves the taste of the capsule.
2. The flavored capsule of claim 1 , wherein the forming agent comprises gelatin and the capsule softener comprises a polyol.
3. The flavored capsule of claim 1 , wherein the forming agent comprises a vegetable starch and the capsule softener comprises a polyol.
4. The flavored capsule of claim 2 , wherein the polyol comprises sorbitol or glycerol.
5. The flavored capsule of claim 3 , wherein the polyol comprises sorbitol or glycerol.
6. The flavored capsule of claim 2 , further comprising a dose of fish oil encapsulated therein, whereby the water-soluble flavoring promotes the ingestion of the fish oil dose.
7. The flavored capsule of claim 3 , further comprising a dose of fish oil encapsulated therein, whereby the water-soluble flavoring promotes the ingestion of the fish oil dose.
8. The flavored capsule of claim 6 , further comprising an oil soluble flavoring in the fish oil dose.
9. The flavored capsule of claim 7 , further comprising an oil soluble flavoring in the fish oil dose.
10. A fish oil capsule for palatable presentation of fish oil comprising:
a) an external capsule, said external capsule comprising a forming agent, a capsule softener, water, and a water soluble flavoring, wherein said forming agent is chosen from the group consisting of gelatin and vegetable starch, said capsule softener is present in a concentration in the range of about 10% to about 35%, water is present in a concentration between about 6% and about 10%, and the water soluble flavoring is present in a quantity which improves the taste of the capsule; and
b) a fish oil dose, said external capsule encapsulating said fish oil dose.
11. The fish oil capsule of claim 10 wherein the capsule softener comprises a polyol.
12. The fish oil capsule of claim 11 wherein the polyol comprises glycerol or sorbitol.
13. The fish oil of claim 1o wherein the fish oil dose further comprises an oil soluble flavoring dissolved therein.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US10/646,898 US20040037877A1 (en) | 1999-10-06 | 2003-08-22 | Flavored gelatin capsule and method of manufacture |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US09/416,017 US6346231B1 (en) | 1999-10-06 | 1999-10-06 | Flavored gelatin capsule and method of manufacture |
US10/041,877 US6652879B2 (en) | 1999-10-06 | 2001-10-22 | Flavored gelatin capsule and method of manufacture |
US10/292,999 US6641837B2 (en) | 1999-10-06 | 2002-11-12 | Flavored vegetable starch capsule |
US10/646,898 US20040037877A1 (en) | 1999-10-06 | 2003-08-22 | Flavored gelatin capsule and method of manufacture |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US10/292,999 Continuation US6641837B2 (en) | 1999-10-06 | 2002-11-12 | Flavored vegetable starch capsule |
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US20040037877A1 true US20040037877A1 (en) | 2004-02-26 |
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US09/416,017 Expired - Lifetime US6346231B1 (en) | 1999-10-06 | 1999-10-06 | Flavored gelatin capsule and method of manufacture |
US10/041,877 Expired - Lifetime US6652879B2 (en) | 1999-10-06 | 2001-10-22 | Flavored gelatin capsule and method of manufacture |
US10/292,999 Expired - Lifetime US6641837B2 (en) | 1999-10-06 | 2002-11-12 | Flavored vegetable starch capsule |
US10/646,898 Abandoned US20040037877A1 (en) | 1999-10-06 | 2003-08-22 | Flavored gelatin capsule and method of manufacture |
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US09/416,017 Expired - Lifetime US6346231B1 (en) | 1999-10-06 | 1999-10-06 | Flavored gelatin capsule and method of manufacture |
US10/041,877 Expired - Lifetime US6652879B2 (en) | 1999-10-06 | 2001-10-22 | Flavored gelatin capsule and method of manufacture |
US10/292,999 Expired - Lifetime US6641837B2 (en) | 1999-10-06 | 2002-11-12 | Flavored vegetable starch capsule |
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Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4428927A (en) * | 1981-05-11 | 1984-01-31 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4500358A (en) * | 1982-10-29 | 1985-02-19 | Warner-Lambert Company | Foam capsules |
US4525306A (en) * | 1981-09-21 | 1985-06-25 | Asama Chemical Co., Ltd. | Method for prevention of oxidation of oils and fats and soft capsules containing the treated oils and fats |
US4532126A (en) * | 1982-05-07 | 1985-07-30 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US4719112A (en) * | 1982-10-29 | 1988-01-12 | Warner-Lambert Company | Foam capsules |
US4780316A (en) * | 1983-03-02 | 1988-10-25 | R.P. Scherer Corporation | Gelatin capsule |
US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
US5639474A (en) * | 1993-07-01 | 1997-06-17 | Hanmi Pharm. Ind., Ltd. | Cyclosporin soft capsule composition |
US5656667A (en) * | 1988-08-11 | 1997-08-12 | Norsk Hydro As | Fatty acid composition |
US5681606A (en) * | 1993-02-11 | 1997-10-28 | R. P. Scherer | Method of preparing a water-based beverage |
US5817323A (en) * | 1993-06-28 | 1998-10-06 | R.P. Scherer Corporation | Soft gelatin capsule shell compositions |
US5853761A (en) * | 1995-02-13 | 1998-12-29 | Fujisawa Pharmaceutical Co., Ltd. | Stabilizing agent for oleaginous, physiologically active substances |
US5955102A (en) * | 1998-09-04 | 1999-09-21 | Amway Corporation | Softgel capsule containing DHA and antioxidants |
US6193999B1 (en) * | 1999-03-01 | 2001-02-27 | Banner Pharmacaps, Inc. | Gum acacia substituted soft gelatin capsules |
US6258380B1 (en) * | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
US6280767B1 (en) * | 1998-10-20 | 2001-08-28 | Toaki Capsule Co., Ltd. | Soft gelatin capsule |
US6346231B1 (en) * | 1999-10-06 | 2002-02-12 | Joar Opheim | Flavored gelatin capsule and method of manufacture |
US6979456B1 (en) * | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3307353C2 (en) * | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Soft gelatin capsule containing polyethylene glycol and process for their production |
DE3629386A1 (en) * | 1986-08-29 | 1988-03-03 | Scherer Gmbh R P | GELATINE CAPSULES AND METHOD FOR THEIR PRODUCTION |
DE69013923T2 (en) * | 1989-08-17 | 1995-03-16 | Cortecs Ltd | MEDICINAL FORMULATIONS. |
US5444054A (en) * | 1994-04-01 | 1995-08-22 | Abbott Labatories | Method of treating ulcerative colitis |
US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
DE69818607T2 (en) * | 1997-05-30 | 2004-07-29 | Osmotica Corp. | MULTILAYER OSMOSIS DEVICE |
-
1999
- 1999-10-06 US US09/416,017 patent/US6346231B1/en not_active Expired - Lifetime
-
2001
- 2001-10-22 US US10/041,877 patent/US6652879B2/en not_active Expired - Lifetime
-
2002
- 2002-11-12 US US10/292,999 patent/US6641837B2/en not_active Expired - Lifetime
-
2003
- 2003-08-22 US US10/646,898 patent/US20040037877A1/en not_active Abandoned
Patent Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4428927A (en) * | 1981-05-11 | 1984-01-31 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4525306A (en) * | 1981-09-21 | 1985-06-25 | Asama Chemical Co., Ltd. | Method for prevention of oxidation of oils and fats and soft capsules containing the treated oils and fats |
US4532126A (en) * | 1982-05-07 | 1985-07-30 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4500358A (en) * | 1982-10-29 | 1985-02-19 | Warner-Lambert Company | Foam capsules |
US4719112A (en) * | 1982-10-29 | 1988-01-12 | Warner-Lambert Company | Foam capsules |
US4780316A (en) * | 1983-03-02 | 1988-10-25 | R.P. Scherer Corporation | Gelatin capsule |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US5656667A (en) * | 1988-08-11 | 1997-08-12 | Norsk Hydro As | Fatty acid composition |
US5141961A (en) * | 1991-06-27 | 1992-08-25 | Richrdson-Vicks Inc. | Process for solubilizing difficulty soluble pharmaceutical actives |
US5200191A (en) * | 1991-09-11 | 1993-04-06 | Banner Gelatin Products Corp. | Softgel manufacturing process |
US5681606A (en) * | 1993-02-11 | 1997-10-28 | R. P. Scherer | Method of preparing a water-based beverage |
US5817323A (en) * | 1993-06-28 | 1998-10-06 | R.P. Scherer Corporation | Soft gelatin capsule shell compositions |
US5639474A (en) * | 1993-07-01 | 1997-06-17 | Hanmi Pharm. Ind., Ltd. | Cyclosporin soft capsule composition |
US5853761A (en) * | 1995-02-13 | 1998-12-29 | Fujisawa Pharmaceutical Co., Ltd. | Stabilizing agent for oleaginous, physiologically active substances |
US6979456B1 (en) * | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
US5955102A (en) * | 1998-09-04 | 1999-09-21 | Amway Corporation | Softgel capsule containing DHA and antioxidants |
US6280767B1 (en) * | 1998-10-20 | 2001-08-28 | Toaki Capsule Co., Ltd. | Soft gelatin capsule |
US6193999B1 (en) * | 1999-03-01 | 2001-02-27 | Banner Pharmacaps, Inc. | Gum acacia substituted soft gelatin capsules |
US6258380B1 (en) * | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
US6346231B1 (en) * | 1999-10-06 | 2002-02-12 | Joar Opheim | Flavored gelatin capsule and method of manufacture |
US6641837B2 (en) * | 1999-10-06 | 2003-11-04 | Joar Opheim | Flavored vegetable starch capsule |
US6652879B2 (en) * | 1999-10-06 | 2003-11-25 | Joar Opheim | Flavored gelatin capsule and method of manufacture |
Non-Patent Citations (1)
Title |
---|
Brand et al. "The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro", 2001. * |
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US20100158958A1 (en) * | 2005-12-22 | 2010-06-24 | Nachiappan Chidambaram | Gastric reflux resistant dosage forms |
US9693966B2 (en) * | 2005-12-22 | 2017-07-04 | Banner Life Sciences Llc | Gastric reflux resistant dosage forms |
US10182990B2 (en) | 2005-12-22 | 2019-01-22 | Patheon Softgels Inc. | Gastric reflux resistant dosage forms |
US20090208608A1 (en) * | 2008-02-20 | 2009-08-20 | Barlean's Organic Oils, Llc | Flavored softgel capsule and method of manufacturing thereof |
US20090214641A1 (en) * | 2008-02-26 | 2009-08-27 | Joar Opheim | Sweetened Capsules for Administration |
WO2009108308A1 (en) * | 2008-02-26 | 2009-09-03 | Nordic Naturals, Inc. | Sweetened capsules for administration |
US9782374B2 (en) | 2014-06-23 | 2017-10-10 | Patheon Softgels Inc. | All-natural enteric soft capsules |
US9987240B2 (en) | 2014-06-23 | 2018-06-05 | Patheon Softgels, Inc. | All-natural enteric soft capsules |
US10357467B2 (en) | 2014-06-23 | 2019-07-23 | Patheon Softgels, Inc. | All-natural enteric soft capsules |
Also Published As
Publication number | Publication date |
---|---|
US20030064096A1 (en) | 2003-04-03 |
US6346231B1 (en) | 2002-02-12 |
US20020058064A1 (en) | 2002-05-16 |
US6652879B2 (en) | 2003-11-25 |
US6641837B2 (en) | 2003-11-04 |
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