US20040044350A1 - Steerable access sheath and methods of use - Google Patents
Steerable access sheath and methods of use Download PDFInfo
- Publication number
- US20040044350A1 US20040044350A1 US10/441,753 US44175303A US2004044350A1 US 20040044350 A1 US20040044350 A1 US 20040044350A1 US 44175303 A US44175303 A US 44175303A US 2004044350 A1 US2004044350 A1 US 2004044350A1
- Authority
- US
- United States
- Prior art keywords
- access system
- obturator
- pullwire
- articulating members
- sheath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0138—Tip steering devices having flexible regions as a result of weakened outer material, e.g. slots, slits, cuts, joints or coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/00078—Insertion part of the endoscope body with stiffening means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/005—Flexible endoscopes
- A61B1/0051—Flexible endoscopes with controlled bending of insertion part
- A61B1/0055—Constructional details of insertion parts, e.g. vertebral elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/005—Flexible endoscopes
- A61B1/0051—Flexible endoscopes with controlled bending of insertion part
- A61B1/0057—Constructional details of force transmission elements, e.g. control wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/062—Needle manipulators
- A61B17/0625—Needle manipulators the needle being specially adapted to interact with the manipulator, e.g. being ridged to snap fit in a hole of the manipulator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0643—Surgical staples, i.e. penetrating the tissue with separate closing member, e.g. for interlocking with staple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
- A61B17/1227—Spring clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/128—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
- A61B17/1285—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00579—Barbed implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00588—Rigid or stiff implements, e.g. made of several rigid parts linked by hinges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00592—Elastic or resilient implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00606—Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00623—Introducing or retrieving devices therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
- A61B2017/00783—Valvuloplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0409—Instruments for applying suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0417—T-fasteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0419—H-fasteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/047—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery having at least one proximally pointing needle located at the distal end of the instrument, e.g. for suturing trocar puncture wounds starting from inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0472—Multiple-needled, e.g. double-needled, instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0474—Knot pushers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0487—Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks
- A61B2017/0488—Instruments for applying suture clamps, clips or locks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B2017/0496—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B2017/06052—Needle-suture combinations in which a suture is extending inside a hollow tubular needle, e.g. over the entire length of the needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06066—Needles, e.g. needle tip configurations
- A61B2017/06076—Needles, e.g. needle tip configurations helically or spirally coiled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06066—Needles, e.g. needle tip configurations
- A61B2017/061—Needles, e.g. needle tip configurations hollow or tubular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
- A61B2017/06171—Sutures helically or spirally coiled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0641—Surgical staples, i.e. penetrating the tissue having at least three legs as part of one single body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B2017/088—Sliding fasteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2901—Details of shaft
- A61B2017/2908—Multiple segments connected by articulations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/10—Eye inspection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M2025/0161—Tip steering devices wherein the distal tips have two or more deflection regions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0152—Tip steering devices with pre-shaped mechanisms, e.g. pre-shaped stylets or pre-shaped outer tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0155—Tip steering devices with hydraulic or pneumatic means, e.g. balloons or inflatable compartments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M25/0133—Tip steering devices
- A61M25/0158—Tip steering devices with magnetic or electrical means, e.g. by using piezo materials, electroactive polymers, magnetic materials or by heating of shape memory materials
Definitions
- the present invention relates to an access sheath for endoluminally accessing a body cavity and directing the passage of interventional devices therethrough into the cavity.
- the present invention relates to an articulatable access sheath which directs the interventional devices into the cavity in a desired orientation.
- the present invention relates to vascularly accessing an atrium of the heart to direct an interventional catheter toward a cardiac valve.
- a catheter is typically passed through one or more body lumens, such as through the vascular system, to the target location.
- vascular system When the vascular system is used, a guidewire and dilator is inserted into an artery or vein through a relatively small incision in the patient's body. The guidewire and dilator is then threaded through the patient's vasculature to reach the desired target area. Often the dilator is covered by a sheath which is passed with the dilator to the target location. The dilator is then removed and the sheath is used as a conduit for access for a variety of medical devices to access the target location.
- Such devices may include catheters, surgical instruments, fiber optic cables for visualization, lasers, electronic devices, or sensors capable of monitoring physiological parameters in situ, to name a few.
- access reduces the need for traditional invasive surgery, challenges arise related to control, manipulation, and positioning of instruments near the target location, particularly within a target body cavity.
- a device advanced to the cavity will typically protrude into the cavity at the angle in which it entered. If the target tissue is not within this pathway, the device will need to be steered toward the target tissue. If more than one device is used during a procedure, each device will need to be steered and repositioned when used. This increases the time and cost of the procedure and also the risk of misalignment.
- the catheter and/or access sheath may be tracked from a puncture in the femoral vein, through the inferior vena cava, into the right atrium and through a puncture in the intra-atrial septum to the left atrium.
- This pathway may then be used to access the mitral valve which lies between the left atrium and the left ventricle.
- the mitral valve may be located below and to the right or left requiring the devices which are inserted to be directed downward and perhaps laterally after entry, toward the mitral valve.
- devices used for applying interventional therapies to the mitral valve may require precise alignment with the valve commissures, leaflets, or coaptation line to perform the procedure.
- each instrument would be dependent upon proper positioning in relation to the valve. This would require that positioning or steering mechanisms be built into each instrument and each instrument would be required to be properly positioned when introduced. This adds cost, complexity, and time to the overall procedure.
- an access sheath having a pre-shaped curve at its distal end has been developed to both assist in negotiating twists and branches common in a patient's arterial or venous system and to maintain a shape once positioned within a target cavity. Since the pre-shaped curve is fixed into the access sheath at the time of manufacture, the radius and extent of the curvature generally cannot be altered. Due to anatomical variations, extensive presurgical planning would be necessary to determine the correct curvature of the access sheath. Such tailoring would be prohibitively complex and a predicted curvature would most likely still require additional repositioning once inside the body. Continuously replacing the pre-shaped access catheter in hopes of obtaining the proper curvature would be expensive and time consuming, possibly placing the patient at additional risk.
- Steerable guide catheters and delivery catheters have been developed to more effectively navigate through the tortuous pathways of some body lumens, particularly the vascular system.
- steering is accomplished through a combination of torqueing the proximal end of the catheter and pulling various pullwires to deflect the distal end of the catheter.
- torque transmission has not been perfected in such steerable catheters. Due to the length of the catheter body between a proximal control end and the distal tip, torsion can tend to accumulate as the proximal end of the catheter is twisted to rotate the tip. The accumulated torsional moment may release unevenly, resulting in skipping or rapid rotation of the distal tip inside the vessel.
- the walls of such steerable catheters generally comprise a series of layers.
- a woven metal or polymeric tubular braid may be sandwiched between an inner tubular sleeve and an outer tubular jacket.
- improved torquability generally results in increased wall thickness, which in turn increases the outside diameter of the steerable catheter or reduces any given desired inside diameter.
- such a heavy braided construction is often difficult to deflect by actuation of pullwires.
- the deflectable section can be softened with coils or softer polymers to allow it to be deflected to a much greater extent. However, this reduces the catheter's ability to transmit torque to or through this softer section.
- these softer sections may not offer adequate support for interventional devices or tools which are later passed through its inner lumen.
- an access sheath having an articulatable distal end which does not rely on permanent pre-shaping or torque transmission for positioning the access sheath within a target body cavity in a desired orientation.
- the articulatable access sheath should have a large lumen diameter to accommodate the passage of a variety of interventional devices, should have good wall strength to avoid kinking or collapse of the sheath when bent around tight curves, and should have good column and tensile strength to avoid deformation when the interventional devices are passed through the lumen.
- the sheath articulation mechanisms should provide for a high degree of controlled deflection at the distal end of the sheath but should not take up significant lumen area to allow for passage of interventional devices.
- the access sheath should be articulatable in a manner which allows compound curves to be formed, for example curvature within more than one plane. Such manipulation should allow fine control over the distal end to accommodate anatomical variations within the same type of body cavity and for use in different types of body cavities.
- Hermann et al. (U.S. Pat. No. 5,843,031) describes a large-diameter introducer sheath having a hemostasis valve and a removable steering mechanism. The steering mechanism is described to be within an obturator which is positioned within the sheath during positioning and is then removable.
- Adair (U.S. Pat. No. 5,325,845) describes a steerable sheath having an articulatable member which is deformable to allow articulation.
- Kordis (U.S. Pat. No. 5,636,634) describes a sheath which is positioned by a separate, dedicated steering catheter.
- a number of the other references refer to guidewires or catheters which themselves are steerable by means of wires.
- Stevens-Wright et al. U.S. Pat. No. 5,462,527) describes a handle which applies tension selectively to two or four pull cables to steer an attached catheter.
- Stevens-Wright et al. U.S. Pat. No. 5,715,817) further describes improvements in actuating the tip of the catheter described in Stevens-Wright et al. '527.
- Hammerslag U.S. Pat. No. 5,108,368 describes a steerable guidewire or catheter wherein the tip is deflectable through a full 360 degree range of motion by means of axially moveable deflection wires extending throughout.
- Hammerslag U.S. Pat. No. 5,820,592 describes a guide catheter through which a torque control wire or a deflection wire extends. Manipulating an actuator controls the wire to steer or aim the guide catheter.
- Savage U.S. Pat. No. 5,368,564
- Savage et al. U.S. Pat. No. 5,507,725) also describe a steerable catheter having wire members extending through the catheter wall to manipulate the tip.
- the present invention provides devices, systems, methods and kits for endoscopically accessing a body cavity and providing a directed pathway toward a target tissue within the cavity.
- the directed pathway is provided by an access sheath which is positioned in a desired configuration, generally directed toward the target tissue. Interventional devices may then be passed through the sheath to the target tissue. Depending on the location of the target tissue and the desired angle of approach, the access sheath may be required to maintain one or more curves in one or more planes to properly direct the interventional devices.
- the access sheath of the present invention has a portion which comprises a series of articulating members to allow the sheath to form these curvatures.
- the access sheath has a locking feature to hold the articulating members in place and maintain the desired configuration.
- the articulating members may be positioned by an articulating mechanism within the sheath, such as pullwires which extend through at least one of the articulating members.
- an articulatable obturator may be positioned within the sheath, wherein articulation of the obturator in turn moves the encasing sheath into the desired articulated position. The obturator is then removed and the sheath remains in the articulated position.
- an articulatable access sheath for accessing the body cavity.
- the access sheath comprises a shaft having a proximal end, a distal end and a central lumen therethrough.
- the distal end is sized appropriately for the intended method of approaching the body cavity.
- the body cavity may be approached laparoscopically, thorascopically, endoscopically, endovascularly, percutaneously or by any suitable method.
- the distal end of the access sheath is passable through a body lumen, such as a blood vessel within the vascular system.
- a chamber of the heart which can be accessed either through the femoral vein and inferior vena cava or the superior vena cava into the right atrium, or through a femoral or axillary artery and the aorta into the left ventricle.
- the distal end may further be configured to penetrate the interatrial septum so as to be passed from the right atrium to the left atrium.
- Other body lumens through which the device may be positioned include the esophagus for approaching the stomach, the colon for approaching the gastrointestinal system, the trachea for approaching the lungs, or the urethra for approaching the urinary tract.
- the distal end of the access sheath is passable directly through body tissues, such as in a direct access procedure to the heart.
- the access sheath may be positioned in a penetration in the chest wall and used to access the outside of the heart to perform diagnostic and interventional procedures such as ablation of the pulmonary veins to treat atrial fibrillation.
- the sheath may be passed through the wall of the heart to access the interior chambers thereof.
- the central lumen extends through the length of the shaft and is sized for passage of an interventional device, such as a catheter or tool, to perform procedures such as valve repair, electrophysiological mapping and ablation, and septal defect repair.
- the central lumen is generally relatively large in comparison to the total cross section of the shaft.
- the shaft also includes a portion which comprises a series of articulating members.
- the articulating members may have any suitable shape, however in preferred embodiments the members comprise interfitting domed rings.
- the ring aspect provides a hollow interior which forms the central lumen.
- the dome aspect provides a surface which is rotateable against an interfitting surface of an adjacent domed ring. Since the domed rings are individually rotateable, the series of articulating members can be positioned in a variety of arrangements to follow any pathway.
- the portion of the shaft comprising the series of articulating members is the distal end. This is because the distal end is usually advanced into the body cavity and benefits from articulation to properly direct interventional devices which are passed through.
- the articulating portion may be disposed at any location along the shaft and more than one portion having a series of articulating members may be present.
- the sheath includes at least one pullwire to articulate the articulating members.
- the pullwires extend through at least one of the articulating members to move the portion of the shaft having the articulating members into an articulated position.
- the pullwires can extend through the central lumen or through individual lumens in the walls of the articulating members. It may be appreciated that more than one pullwire may extend through any given lumen.
- a plurality of pullwires are present at locations around the perimeter of the central lumen. The presence of each pullwire allows articulation of the shaft in the direction of the pullwire.
- pullwires can be symmetrically placed along the sides of the shaft. Although any number of pullwires are possible, generally, four to eight pullwires are preferred.
- Each pullwire is attached to the shaft at a location chosen to result in particular curvature of the shaft when tension is applied to the pullwire. For example, if a pullwire is attached to the most distal articulating member in the series, applying tension to the pullwire will compress the articulating members proximal to the attachment point along the path of the pullwire. This results in a curvature forming in the direction of the pullwire proximal to the attachment point. It may be appreciated that the pullwires may be attached to any location along the shaft and is not limited to attachment to articulating members.
- pullwires are attached at various attachment points, each attachment point providing a different curvature or altering the overall articulated position of the sheath.
- first pullwire is fixedly attached to the shaft at a primary attachment point
- applying tension to the first pullwire arcs the series of articulating members proximal to the primary attachment point to form a primary curve. If the distal end terminates in a distal tip and the primary attachment point is located at the distal tip, the primary curve will extend through the entire series of articulating members. If the primary attachment point is located mid-way along the series of articulating members, the primary curve will extend through the series of articulating members proximal to the primary attachment point.
- the primary and secondary curves may lie in the same plane or in different planes. In some embodiments, the planes are substantially orthogonal.
- a third pullwire is fixedly attached to the shaft at a distal attachment point and applying tension to the third pullwire moves the distal end through an angle theta.
- the third pullwire moves the distal tip through the angle theta.
- the angle theta will be described and illustrated in more detail in later sections.
- the angle theta generally serves to tip or angle the distal tip in relation to a center line to further refine the articulated position of the sheath.
- the angle theta lies in a plane which is different from at least the primary curve or the secondary curve and sometimes both. In fact, the angle theta may lie in a plane which is orthogonal to both the primary curve and the secondary curve.
- Tension is applied to the pullwires by manipulation of actuators located on a handle.
- the handle is connected with the proximal end of the articulatable access sheath and remains outside of the body.
- the actuators may have any suitable form, including buttons, levers, knobs, switches, toggles, dials, or thumbwheels, to name a few.
- Each actuator may apply tension to an individual pullwire or to a set of pullwires, or may actuate the articulation element according to its type.
- a different actuator is used to form each curvature, such as the primary curvature and secondary curvature, and to cause movement through the angle theta.
- the handle may also include a locking actuator to actuate a locking mechanism.
- Locking holds the articulating members in the articulated position.
- the sheath is maintained in the articulated position while interventional devices are passed therethrough.
- the sheath will retain sufficient rigidity to deflect and guide a non-steerable interventional device through its central lumen and direct the device to the body cavity, particularly to the target tissue within the body cavity.
- the locking feature comprises sufficient friction between articulating members so that the members are held in place, either by friction of one articulating member against another or by the presence of frictional elements between the articulating members.
- the locking feature comprises a locking mechanism which includes a mechanism for holding at least one of the pullwires in the tensioned position.
- tensioning of a pullwire typically draws a portion of the articulating members together, forming a curve.
- the articulated members can often maintain this arrangement.
- the ability to maintain the arrangement is increased. Therefore, some locking mechanisms will hold all of the pullwires in a tensioned position.
- the portions may be individually locked by holding tension in the appropriate pullwires. This may be useful, for example, when a desired primary curve is established and a secondary curve is undertaken. The primary curve may be locked in place prior to creating the secondary curve to allow independent creation of each curve.
- any number of curves or shapes may be formed throughout the series of articulating members.
- permanent curves may also be provided throughout the portion of the shaft comprising the series of articulating members. Such permanent curves may be a result of the shapes of the articulating members, the way in which the articulating members are arranged or fit together, or of any other mechanism.
- any number of curves or shapes may be pre-formed throughout portions of the shaft other than the portion of the shaft comprising the series of articulating members.
- alternative articulation elements may also be used, such as pushrods, thermally-controlled shape memory alloy wires, or hydraulic or pneumatic fluids, to name a few.
- an access system for accessing a body cavity comprises a sheath which includes a shaft having a proximal end, a distal end and a central lumen therethrough. Again, the distal end is sized appropriately for the intended method of approaching the body cavity. And, a portion of the shaft comprises a series of articulating members which are lockable in a fixed position.
- the access system further comprises an obturator sized for passage through the central lumen and having means for articulating the obturator. Articulation of the obturator positions the articulating members of the sheath in an articulated position which becomes the fixed position upon locking. The obturator is then removed so that interventional devices may be passed therethrough.
- the portion of the shaft comprising the series of articulating members may be the same or similar to that described above in relation to the articulatable access sheath.
- the articulating members comprise interfitting domed rings, each domed ring independently rotateable against an adjacent domed ring.
- pullwires may be present which pass through the at least one of the articulating members.
- the pullwires are not used to position the articulating members, rather the pullwires are used to lock the articulating members in the fixed position.
- the pullwires hold the articulating members in contact with enough frictional force to hold or lock the articulating members in the fixed position.
- tension may be applied to some or all of the pullwires to further wedge the articulating members together and therefore lock them in place.
- the articulating members are moved into the articulated position by action of the obturator.
- the obturator can be moved into any arrangement.
- the obturator may be shaped to have bends, arcs, curves or angles.
- Such shaping can be achieved by any suitable mechanism, including pullwires which act similarly to those described above in relation to articulating the articulatable access sheath.
- the shaping of the obturator applies forces to the central lumen and transfers the shaping to the surrounding sheath.
- the articulated position can include any number of curves, including a primary curve, secondary curve or angle theta, to name a few. And, the curves may lie in the same or different planes.
- Articulation of the obturator can be achieved by manipulation of actuators located on an obturator handle.
- the obturator handle is connected with the proximal end of the obturator and remains outside of the body.
- the actuators may have any suitable form, including buttons, knobs, switches, toggles, dials, or thumbwheels, to name a few.
- Each actuator may apply tension to an individual pullwire or to a set of pullwires.
- a different actuator is used to form each curvature, such as the primary curvature and secondary curvature, and to cause movement through the angle theta.
- the obturator handle may also include an obturator locking actuator to actuate an obturator locking mechanism.
- the obturator locking mechanism locks the obturator in the articulated position. By such locking, the obturator is maintained in the articulated position while the sheath is then locked in position.
- the locking mechanism of both the obturator and sheath include a mechanism for holding at least one of the pullwires in the tensioned position. Some locking mechanisms will hold all of the pullwires in a tensioned position. When individual pullwires affect individual portions of the obturator or the series of articulated members, the portions may be individually locked by holding tension in the appropriate pullwires.
- the obturator can then be unlocked and removed. Or, when the obturator has a permanent heat-set curve, the locked sheath will be sufficiently rigid enough to allow removal of the pre-curved obturator without changing the shape of the sheath. The sheath will also retain sufficient rigidity to deflect and guide a non-steerable interventional device through its central lumen and direct the device to the body cavity, particularly to the target tissue within the body cavity.
- the obturator may only form a single curve yet may be used to form compound or multiple curves in the sheath.
- the obturator may be positioned in a first location along the sheath forming a first curve. The sheath is then locked in place in this first location to hold the first curve. The obturator may then be positioned in a second location along the sheath forming a second curve. Likewise, the sheath is then locked in the second location to hold the second curve.
- multiple or compound curves may be formed from an obturator capable of forming a single curve. This concept may be extrapolated to cover obturators capable of forming more than a single curve yet are used to form curves in sheath which are more complex or of a higher number.
- the method includes advancing a sheath through a body lumen to the body cavity, wherein the sheath includes a shaft having a proximal end, a distal end, a central lumen therethrough, and a portion of the shaft comprises a series of articulating members.
- the sheath can be used to access any body cavity through any pathway, such as laparoscopically, thorascopically, endoscopically, endovascularly or percutaneously, the sheath may particularly be used to access one or more chambers of the heart.
- the chambers of the heart provide access to many tissues which may be targeted for treatment, such as valves, chordae tendinae, papillary muscles, the Purkinje system, pulmonary veins and coronary arteries, to name a few.
- the left atrium may be accessed to approach the valve from above.
- the sheath may be advanced through the vasculature to the right atrium and passed through the intra-atrial septum to the left atrium.
- the articulating members are then articulated to move the portion of the shaft comprising the series of articulating members into an articulated position. It may be appreciated that the mitral valve may alternatively be approached from below or from the ventricular side by accessing the left ventricle.
- the access sheath may be positioned through a surgical penetration in the chest wall and through a penetration in a wall of the heart to access the cardiac chambers.
- the access sheath is introduced into the right atrium and then advanced across the interatrial septum into the left atrium.
- the articulated position may include any number of curves or shapes to properly direct the sheath toward the target tissue.
- the distal end of the sheath When targeting the mitral valve via the right atrium, the distal end of the sheath extends into the open space of the right atrium.
- the sheath may be articulated to move the distal tip laterally, vertically, or angularly, to name a few.
- the articulated position may include a primary curve in a primary plane parallel to the valve surface. This moves the distal tip laterally in relation to the valve.
- the articulated position may further include a secondary curve in a secondary plane; typically the secondary plane is different from the primary plane and optionally substantially orthogonal to the primary plane.
- the articulated position may further include an angle theta. This moves the distal end vertically and angularly through a plane which differs from the secondary plane. Consequently, the central lumen can be directed toward or away from the valve along a theta plane which is different than the secondary plane and optionally the primary plane.
- Articulating the articulating members may be accomplished by any of the means described above.
- the sheath may further comprise at least one pullwire which extends through at least one of the articulating members. Applying tension to the at least one pullwire would thus articulate the articulating members.
- Locking the articulating members may comprise holding the tension in the at least one pullwire with a locking mechanism. As described previously, locking may be accomplished by holding tension in all of the pullwires.
- interventional devices are then passed through the central lumen, wherein the articulated position directs the interventional device into the body cavity.
- an interventional catheter or tool is passed through the central lumen into the left atrium and directed toward the mitral valve.
- the interventional device may optionally be advanced through the valve, between the leaflets. The desired surgical procedure can then be performed. If additional catheters or tools are needed, the devices may easily be interchanged by removing one and advancing another while the sheath remains in the articulated position.
- the method includes advancing a sheath through a body lumen to a body cavity, wherein the sheath comprises a shaft having a proximal end, a distal end, a central lumen therethrough and a portion of the shaft comprises a series of articulating members.
- the method includes passing an obturator through the central lumen and articulating the obturator to position the articulating members in an articulated position.
- the obturator may be articulated by any of the means described previously.
- the articulated members are then locked in the articulated position and the obturator is removed to allow passage of an interventional device through the central lumen, wherein the articulated position directs the device into the body cavity.
- kits for such use.
- the kits may comprise an access sheath and instructions for use.
- the access sheath may be articulatable by means of mechanisms incorporated in the sheath, or the kit may include an articulatable obturator for use in articulating the sheath.
- such kits may further include any of the other system components described in relation to the present invention and any other materials or items relevant to the present invention.
- FIG. 1 is a perspective view of an embodiment of an articulatable access sheath of the present invention.
- FIGS. 2 A- 2 D illustrate examples of articulated positions of the access sheath.
- FIG. 3 is a perspective side view of an access sheath having an additional curve compared to the articulated positions shown in FIGS. 2 A- 2 D.
- FIGS. 4 A- 4 C illustrate a method of using the access sheath for accessing the mitral valve.
- FIG. 5 is a perspective view of the portion of the sheath comprising a series of articulating members.
- FIGS. 6 A- 6 C are side views of articulating members having different types of inner surfaces.
- FIGS. 7 A- 7 D illustrate an embodiment of an articulating member which accommodates four pullwires.
- FIGS. 8 A- 8 D illustrate an embodiment of an articulating member which accommodates eight pullwires.
- FIGS. 9 A- 9 D illustrate an embodiment of an articulating member which accommodates eight pullwires yet has an inner surface which differs from the embodiment shown in FIGS. 8 A- 8 D.
- FIGS. 10 A-E illustrate an embodiment of an articulating member which is designed to reduce possible binding of the pullwires and to increase stability of curves during articulation.
- FIG. 11A illustrates various liners which comprise some embodiments of the access sheath.
- FIG. 11B is a perspective view of an embodiment of an access sheath wherein various pullwires are attached to the shaft at various attachment points.
- FIG. 12 is a perspective view of an embodiment of an access system of the present invention.
- FIGS. 13 A- 13 D illustrate a method of using the access system for accessing the mitral valve.
- FIG. 14 illustrates a kit constructed in accordance with the principles of the present invention
- the sheath 10 comprises a shaft 11 having a proximal end 12 , a distal end 14 , and a central lumen 16 therethrough.
- the distal end 14 is sized to be passable through a body lumen to a body cavity. Therefore, the distal end 14 preferably has an outer diameter in the range of approximately 0.040 in. to 0.500 in., more preferably in the range of 0.130 in. to 0.300 in.
- the central lumen 16 is sized for passage of an interventional device therethrough. Therefore, the central lumen 16 preferably has an inner diameter in the range of approximately 0.030 in.
- a portion of the shaft 11 is comprised of a series of articulating members 18 .
- the articulating members 18 are shown disposed at the distal end 14 of the shaft 11 , terminating in a distal tip 15 .
- the articulating members 18 extend over the distal most 1 to 10 cm of the sheath 10 .
- the articulating members 18 may be disposed at any location along the sheath. For example, if a straight or non-articulating portion is desired near the distal end 14 , the articulating members 18 may be located at a more proximal position.
- the portion of the shaft 11 having the articulating members 18 is movable into an articulated position by actuation of one or more positioning mechanisms. Actuation of the positioning mechanisms is achieved with the use of actuators, such as actuators 22 , 24 , 26 located on a handle 20 .
- the handle 20 is connected to the proximal end 12 of the shaft 11 and remains outside of the patient's body during use. Actuators 22 , 24 , 26 are used to bend, arc or reshape the portion of the shaft 11 comprising articulating members 18 .
- a primary curve actuator 22 can be used to actuate one or more pull wires to form a primary curve in the portion of the shaft 11 comprising the series of articulating members 18 .
- a secondary curve actuator 24 can be actuated to form a secondary curve in the portion of the shaft 11 comprising the series of actuating members 18 .
- a theta actuator 26 can be manipulated to move the distal tip 15 through an angle theta.
- a locking actuator 28 may be used to actuate a locking mechanism to lock the articulating members 18 in the articulated position.
- Actuators 22 , 24 , 26 are illustrated as thumbwheels and actuator 28 is illustrated as a rotating knob. It may be appreciated that such actuators 22 , 24 , 26 , 28 and any additional actuators located on the handle 20 may take any suitable form including knobs, buttons, levers, switches, toggles, sensors or other devices.
- the handle 20 may include a numerical or graphical display of information such as data indicating the articulated position of the sheath 10 .
- FIGS. 2 A- 2 D illustrate examples of articulated positions that the articulating members 18 of the access sheath 10 may hold.
- the articulating members 18 are configured to allow movement into an articulated position which includes a primary curve 40 .
- the primary curve 40 typically has a radius of curvature 42 in the range of approximately 0.125 in. to 1.000 in., preferably in the range of approximately 0.250 in. to 0.500 in.
- the articulating members 18 lie in a single plane X.
- An axis x, transversing through the center of the central lumen 16 at the distal tip 15 lies within plane X.
- the articulating members 18 may further be configured to so that the articulated position further includes a secondary curve 46 .
- the secondary curve 46 typically has a radius of curvature 48 in the range of approximately 0.050 in. to 0.750 in., preferably in the range of approximately 0.125 in. to 0.250 in.
- the secondary curve 46 can lie in the same plane as the primary curve 40 , plane X, or it can lie in a different plane, such as plane Z as shown. In this example, plane Z is substantially orthogonal to plane X.
- Axis z, transversing through the center of the central lumen 16 at the distal tip 15 lies within plane Z.
- axis x and axis z are at substantially 90 degree angles to each other; however, it may be appreciated that axis x and axis z may be at any angle in relation to each other.
- the primary curve 40 and the secondary curve 46 lie in different planes, particularly in substantially orthogonal planes, the curves 40 , 46 may alternatively lie in the same plane. Referring now to FIG.
- the articulating members 18 may be further manipulated to allow the distal tip 15 to move through an angle theta 50 .
- the angle theta 50 is in the range of approximately ⁇ 100° to +100°, preferably in the range of approximately ⁇ 50° to +50°.
- the angle theta 50 lies within a plane Y.
- axis y which runs through the center of the central lumen 16 at the distal tip, forms the angle theta 50 with axis z.
- plane Y is orthogonal to both plane X and plane Z. Axes x, y, z all intercept at a point within the central lumen 16 which also coincides with the intersection of planes X, Y, Z.
- FIG. 2D illustrates movement of the distal tip through an angle theta 50 on the opposite side of axis z.
- the angle theta 50 is measured from the axis z to the axis y, which runs through the center of the central lumen 16 at the distal tip 15 .
- the angle theta 50 lies in plane Y.
- the primary curve 40 , secondary curve 46 , and angle theta 50 can all lie in different planes, and optionally in orthogonal planes.
- the planes within which the primary curve 40 , secondary curve 46 and angle theta 50 lie may be mutually dependent and therefore would allow the possibility that some of these lie within the same plane.
- the articulating members 18 may be configured to provide additional curves or shapes.
- an additional curve 54 may be formed by the articulating members 18 proximal to the primary curve 40 , secondary curve 46 , and angle theta 50 .
- Such additional curves 54 may be formed by the articulating members 18 by manipulation of the actuators on the handle 20 , or the curves 54 may be permanently preformed.
- any number of curves or shapes may be pre-formed throughout portions of the sheath other than the portion of the sheath comprising the series of articulating members 18 .
- pre-formed portions may be intermixed with the portion of the sheath comprising the series of articulating members 18 , such as in an alternating pattern.
- any number of curves may be formed in the access sheath 10 to create the articulated position.
- FIGS. 4 A- 4 C illustrate a method of using the access sheath 10 for accessing the mitral valve MV.
- the access sheath 10 may be tracked from a puncture in the femoral vein, through the interior vena cava and into the right atrium.
- the access sheath 10 may be punctured through a fossa F in the intra-atrial septum S.
- the access sheath 10 is then advanced through the fossa F so that the distal tip 15 is directed over the mitral valve MV.
- this approach serves merely as an example and other approaches may be used, such as through the jugular vein, femoral artery, port access or direct access, to name a few.
- a primary curve 40 may be formed by the series of articulating members 18 , as described above. In this example, formation of the primary curve 40 moves the distal tip 15 within a primary plane, corresponding to previous plane X, parallel to the valve surface. This moves the distal tip 15 laterally along the short axis of the mitral valve MV, and allows the distal tip 15 to be centered over the opening 60 . In this articulated position, any interventional devices which are passed through the central lumen 16 would be directed horizontally over the valve MV. To direct catheters or tools into the opening 60 , it is necessary that the distal tip 15 is pointed downward towards the mitral valve MV.
- the access sheath 10 is shown in an articulated position which includes a secondary curve 46 in a secondary plane, corresponding to previous plane Z. Formation of the secondary curve 46 moves the distal tip 15 vertically and angularly between the commissures C, directing the central lumen 16 toward the mitral valve MV. In this articulated position an interventional device which is passed through the central lumen 16 would be directed toward and/or through the opening 60 .
- the primary curve 40 and the secondary curve 46 may be varied to accommodate different anatomical variations of the valve MV and different surgical procedures, further adjustment may be desired beyond these two curvatures for proper positioning of the access sheath 10 .
- the access sheath 10 may include additional curvatures throughout the articulating members 18 and/or include the ability of the distal tip 15 to move angularly through an angle theta 50 . This moves the tip vertically and angularly through a theta plane, corresponding to previous plane Y. Movement of the distal tip 15 through the angle theta 50 in either direction is shown in dashed line in FIG. 4B. Consequently, the central lumen 16 can be directed toward the mitral valve MV within a plane which differs from the secondary plane. After such movements, the access sheath 10 will be in an articulated position which positions the distal tip 15 so that the opening of the central lumen 16 at the tip 15 faces the desired direction.
- the locking feature may simply be the articulating members holding the desired articulated position by friction during the articulation process. In this situation, the members are essentially already locked in place.
- the locking feature may alternatively be a locking mechanism which is activated, such as simultaneous tensioning of cables to compress the articulation members and locking of the cables in this tensioned position. In any case, such locking provides stiffness in the access sheath 10 for the passage of interventional devices 70 , as illustrated in FIG. 4C.
- the interventional device 70 can be passed through the central lumen 16 toward the target tissue, in this case the mitral valve MV.
- Positioning of the distal end 15 over the opening 60 allows the device 70 to pass through the opening 60 between the leaflets LF if desired, as shown. At this point, any desired surgical procedure may be applied to the mitral valve for correction of regurgitation or any other disorder.
- each articulating member 18 may have any shape, particularly a shape which allows interfitting or nesting as shown. In addition, it is desired that each member 18 have the capability of independently rotating against an adjacent articulating member 18 .
- the articulating members 18 comprise interfitting domed rings 84 .
- the domed rings 84 each include a base 88 and a dome 86 .
- the base 88 and dome 86 have a hollow interior which, when the domed rings 84 are interfit in a series, forms a central lumen 16 .
- dome 86 allows each articulating member 18 to mate against an inner surface of an adjacent domed ring 84 .
- Dome 86 has a convex curvature selected to provide smooth movement and the desired degree of articulation of adjacent domed rings 84 .
- the curvature may be spherical, parabolic, or other rounded shape.
- Domes 86 could alternatively comprises one or a series of frustoconical surfaces.
- Base 88 may have a cylindrical, frustoconical, dome-shaped or other suitable external shape.
- the interfitting domed rings 84 are connected by at least one pullwire 80 .
- Such pullwires typically extend through the length of the access sheath 10 and at least one of the interfitting domed rings 84 to a fixation point where the pullwire 80 is fixedly attached to the shaft 11 .
- the at least one pullwire 80 arcs the series of interfitting domed rings 84 proximal to the attachment point to form a curve.
- pulling or applying tension on at least one pullwire steers or deflects the access sheath 10 in the direction of that pullwire 80 .
- each interfitting domed ring 84 may comprise one or more pullwire lumens 82 disposed around the periphery of each domed ring 84 through which the pullwires 80 are threaded.
- the pullwires 80 may be threaded through the central lumen 16 .
- the pullwires are attached to the sheath 10 at a position where a desired curve is to be formed.
- the pullwires 80 may be fixed in place by any suitable method, such as soldering, gluing, tying, or potting, to name a few. Such fixation method is typically dependent upon the materials used.
- the articulating members 18 may be comprised of any suitable biocompatible material including stainless steel, cobalt chromium, titanium, various other metals, ceramics, as well as polymers or co-polymers.
- the pullwires 80 may be comprised of any suitable material such as fibers, polymeric monofilament or multifilament line, sutures, metal wires, or metal braids. In a preferred embodiment, wires of Nitinol or stainless steel are utilized. Pull wires 80 may me coated with lubricious coatings such as Parylene to reduce friction. Alternatively, sheaths or eyelets (not shown) of low friction material such as Teflon may be provided in lumens 82 or central lumen 16 through which pull wires 80 extend to increase slidability.
- select portions of the articulating members 18 may be fixed together to create desired curves.
- the articulating members 18 comprise domed rings 84
- two, three, four or more domed rings 84 positioned in a row may be fixed in their interfit positions to prevent movement or rotation between the rings 84 .
- This may be achieved by any suitable method such as soldering, gluing, tying, or potting.
- Such fixing will create segments which cannot be articulated, however articulating members 18 on either side of these segments may be articulated. This may be useful in creating certain curves or shapes, particularly square shapes or sharp angles. It may also be appreciated that these select portions of articulating members 18 may be fixed to form either a straight segment or a curved segment.
- the series of articulating members 18 may be locked in place to hold the access sheath 10 in the desired articulated position. Such locking is achieved by holding most or all of the pullwires 80 simultaneously to force each articulating member 18 against its neighboring member 18 . Locking strength is dependent on a number of variables including shape, material, and surface texture of the articulating members 18 . As shown in FIGS. 6A and 6B, the interior shapes of bases 88 and domes 86 are selected to provide the desired strength of locking, degree of articulation, smoothness of movement, and steerability of access sheath 10 . As shown in FIG.
- a sloping inner surface 90 may be formed on the interior of the domed ring 84 .
- a stepped inner surface 92 may be present on the interior of the domed ring 84 .
- the stepped inner surface 92 provides a greater ability to lock tightly, however this may compromise smoothness in steering.
- a domed inner surface 93 may be present on the interior of the domed ring 84 .
- outer surfaces of the dome 86 and/or the inner surfaces 90 , 92 , 93 of the base 88 may be textured or coated with materials to increase friction, or a frictional layer may be applied to each dome 86 or a frictional spacer may be positioned between domed rings 84 .
- the domed rings 84 comprise a metal such as stainless steel
- the rings 84 may be sandblasted to increase surface roughness.
- a sandpaper or a steel brush may also be used to increase roughness, or the surfaces may be sintered or have grooves or bumps.
- the domed rings 84 comprise an injection molded polymer, a desired roughness may be molded into the surfaces or machined or applied after molding.
- FIGS. 7 A- 7 D illustrate an embodiment of an articulating member 18 which accommodates such pullwires 80 .
- FIG. 7A is a cross-sectional view of the base 88 of the articulating member 18 .
- Four pullwire lumens 82 are shown equally spaced throughout the wall of the base 88 . Such spacing allows curvature of the articulating members in each of the four directions. It may be appreciated that any spacing may be achieved between the pullwire lumens 82 to provide curvature in any desired direction.
- FIG. 7 B- 7 C are side views of the member 18 wherein the pullwire lumen 82 is shown to pass through the wall of the base 88 and part of the wall of the dome 86 .
- the sloping inner surface 90 is shown, however, it may be appreciated that any inner surface contour may be used.
- FIG. 7B is a perspective view of the articulating member 18 illustrating all four pullwire lumens 82 passing through the base 88 and partially through the dome 86 .
- FIGS. 8 A- 8 D illustrate an embodiment accommodating eight pullwires.
- FIG. 8A is a cross-sectional view of the base 88 of the articulating member 18 .
- Eight pullwire lumens 82 are shown equally spaced throughout the circumference of the wall of the base 88 . Such number and arrangement of pullwires provides even greater control of the curvature of the access sheath than the embodiment having four pullwires. Again, the lumens may be spaced, sized and arranged to provide any desired curvature.
- FIGS. 8 B- 8 C are side views of the articulating member 18 having eight pullwire lumens 82 . As shown, the pullwire lumens 82 pass through the base 88 and partially through the dome 86 .
- FIGS. 9 A- 9 D illustrate views of an embodiment of the access sheath 10 that includes eight pullwire lumens 82 . However, in this case the embodiment shows a stepped inner surface 92 particularly visible in FIGS. 9 B- 9 C.
- FIGS. 10 A- 10 E illustrate an embodiment of an articulating member 18 which is designed to reduce any possible binding of the pullwires and to increase stability of curves during articulation.
- oblong pullwire lumens 83 are used.
- FIG. 10A a cross-sectional view of the base 88 of the articulating member 18 , four circular pullwire lumens 82 are present along with four oblong pullwire lumens 83 .
- the lumens 82 , 83 are shown equally spaced and alternating throughout the wall of the base 88 . Such spacing allows curvature of the articulating members in each of the four directions.
- the oblong pullwire lumens 83 allows the pullwires to shift or slide along the lumen 83 to provide more gradual, smoother pathways for the pullwires to follow through the articulating members 18 .
- Oblong pull wire lumens 83 may be of oval, elliptical, arcuate, or a rounded rectangular shape in cross-section, with a length in the circumferential direction substantially longer than the width in the radial direction, usually being at least 1.5 times as long, preferably at least twice as long and in some embodiments at least 3 times as long, and may subtend an arc of at least about 5 degrees, and preferably at least about 20 degrees along the circumference of member 18 .
- FIG. 10B is a side view of the member 18 wherein the circular pullwire lumen 82 is shown to pass through the wall of the base 88 and part of the wall of the dome 86 and the oblong pullwire lumens 83 are shown on either side of the circular pullwire lumen 82 .
- circular pullwire lumens 82 alternate with oblong pullwire lumens 83 around the circumference of member 18 .
- dome 86 preferably is divided into a series of annular sections separated by channels in the outer surface thereof, such that contact between adjacent members 18 is limited to the outer surfaces of the annular sections. Some or all of the channels may be axially aligned with oblong pullwire lumens 83 .
- the annular sections of domes 86 preferably subtend an angle of between about 10 and 80 degrees, preferably between about 20 and 45 degrees, along the circumference of members 18 .
- pins are used to keep the members 18 aligned, as illustrated in FIGS. 10 C- 10 E.
- FIG. 10C at least one hole 89 is formed in the wall of the dome 86 and a notch 91 is formed in the base 88 .
- FIG. 10D provides a perspective view of such a hole 89 and notch 91 in the member 18 .
- the holes 89 and notches 91 are formed in pairs on opposite sides of the member 18 .
- pins 93 are inserted into holes 89 and soldered in place.
- Such pins 93 are typically stainless steel and may have an outer diameter of approximately 0.020 in.
- the access sheath 10 may further comprise various liners which extend through the lumens of the articulating members 18 .
- a braid 104 may extend through the central lumen 16 of the shaft 11 .
- Such a braid may be comprised of stainless steel or any appropriate material.
- the braid 104 extends through a length of the shaft 11 to the articulating members 18 .
- the braid 104 provides rigidity and torque response of the shaft 11 , proximal to the articulating members 18 . Therefore, the braid 104 does not extend within the articulating members 18 . Instead, an outer liner 102 and inner liner 100 , supported by a coil 101 or similar structure therebetween, extend throughout the length of the articulating members 18 .
- the coil 101 is comprised of stainless steel or similar material.
- the outer liner 102 comprises 35D PEBAX, PTFE, urethane, nylon or polyethylene, to name a few.
- any suitable polymer may be used.
- the inner liner 100 is comprised of PTFE or a similar low friction material.
- Such liners 100 , 102 allow an interventional device 70 to be passed through the central lumen 16 without interference with the articulating members 18 .
- pullwire lumen liners 106 may extend through the pullwire lumens 102 and encapsulate the pullwires 80 .
- Such pullwire lumen liners 106 may be comprised of a braided polyimide or any suitable material to provide strength, flexibility, and protection of the pullwires 80 .
- an external liner 105 is positioned over the articulating members and is fused to the inner liner 100 and outer liner 102 at the distal tip.
- Such an external liner 105 may be comprised of any suitable material, such as PEBAX 35D, and is generally for protection and continuity of the articulating members and as a blood barrier.
- the pullwires 80 pass through the articulating members 18 and attach to the shaft 11 at various attachment points.
- a first pullwire 120 is shown fixedly attached to the shaft 11 at a primary attachment point 122 . Applying tension to the first pullwire 120 arcs the series of articulation members 18 proximal to the primary attachment point 122 to form a primary curve 40 .
- the primary attachment point 122 is shown midway along the series of articulating members 18 . This provides a primary curve 40 proximal to this point 122 . It may be appreciated that the primary attachment point 122 may be located anywhere along the shaft 11 , including at the distal tip 15 . When attached to the distal tip 15 , applying tension to the first pullwire 120 would create a primary curve 140 across the entire section of articulating members 18 .
- a second pullwire 124 is shown fixedly attached to the shaft 11 at a secondary attachment point 126 . Applying tension to the second pullwire 124 arcs the series of articulating members 18 proximal to the secondary attachment point 126 to form a secondary curve 46 . Since the first pullwire 120 has already created a primary curve 140 in the proximal section, pulling on the second pullwire 124 creates a secondary curve in a section distal to the proximal section.
- a third pullwire 128 may be present which is fixedly attached to the shaft 11 at a distal attachment point 130 so that pulling the third pullwire 128 moves the distal end through an angle theta 50 (see FIG. 4B).
- shaft 11 having pullwires 120 , 124 , 128 which terminate at multiple attachment points 122 , 126 , 130 , respectively, allow the access sheath 10 to be capable of forming a multitude of curves in several different planes.
- the access system 148 comprises an access sheath 150 including a shaft 151 having a proximal end 152 , a distal end 154 , and a central lumen 156 therethrough.
- the distal end 154 is sized to be passable through a body lumen to a body cavity. Therefore, the distal end 14 preferably has an outer diameter in the range of approximately 0.040 in. to 0.500 in., more preferably in the range of 0.130 in. to 0.300 in.
- a portion of the sheath 150 is comprised of a series of articulating members 158 .
- the articulating members 158 are shown disposed at the distal end 154 of the sheath 150 , terminating in a distal tip 155 .
- the articulating members 158 may be disposed at any location along the sheath. For example, if a straight or non-articulating portion is desired near the distal end 154 , the articulating members 158 may be located at a more proximal position. Further, portions of the sheath having articulating members 158 may be interspersed with non-articulating portions, such as in an alternating pattern.
- a handle 160 is mounted to the proximal end 152 of sheath 150 .
- the access system 148 further comprises an obturator 168 sized for passage through the central lumen 156 , as shown.
- the obturator 168 preferably has an outer diameter in the range of approximately 0.025 in. to 0.440 in., more preferably in the range of 0.115 in. to 0.240 in.
- a hemostasis valve of well-known construction (not shown) will be mounted to or within handle 160 in communication with central lumen 156 that allows obturator 168 to be inserted into and removed from central lumen 156 without loss of blood.
- Obturator 168 may have an axial lumen 169 through which a guidewire GW may be slidably inserted to facilitate guiding access system 148 through the vasculature.
- obturator 168 will usually also include a hemostasis valve HV mounted to handle 170 in communication with the guidewire lumen to allow obturator 168 to be slidably introduced over guidewire GW and to allow guidewire GW to be removed from lumen 169 without loss of blood.
- Guidewire GW which may be any of various commercially available guidewires, may optionally be included in the system and kits of the invention.
- the articulating members 158 of the access sheath 150 may be the same or similar to the articulating members 18 of the articulatable access sheath 10 .
- the articulating members may have any shape, particularly a shape which allows interfitting or nesting as shown in FIG. 5.
- pullwires may be present which pass through the articulating members 158 in a manner similar to the pullwire 80 illustrated in FIG. 5. However, the pullwires are not used to position the articulating members 158 .
- the portion of the sheath 150 having the articulating members 158 is movable into an articulated position by action of the obturator 168 or other device which can fit within the central lumen 156 .
- the obturator 168 can be moved into any configuration.
- the obturator 168 can be shaped to have bends, arcs, curves or angles which in turn applies the same configuration to the surrounding sheath 150 .
- Shaping of the obturator 168 can be achieved by any suitable mechanism, such as pullwires which extend through the obturator 158 and can be manipulated in a manner similar to the articulatable access sheath 10 .
- the sheath 150 and obturator 168 can be moved into articulated positions similar to those shown in FIGS. 2 A- 2 D.
- Actuation of the positioning mechanisms is achieved with the use of actuators, such as actuators 170 , 172 , 174 located on an obturator handle 176 .
- the obturator handle 176 may be connectable to a handle 160 of the sheath 150 at a connection joint 178 .
- the actuators 170 , 172 , 173 are used to bend, arc or reshape the obturator 168 underlying the portion of the sheath 150 comprising articulating members 158 .
- a primary curve actuator 170 can be used to actuate one or more pull wires to form a primary curve in the portion of the sheath 150 comprising the series of articulating members 158 .
- a secondary curve actuator 172 can be actuated to form a secondary curve in the portion of the sheath 150 comprising the series of actuating members 158 .
- a theta actuator 174 can be manipulated to move the distal tip 155 through an angle theta.
- a locking actuator 180 on the handle 160 may be used to actuate a locking mechanism to lock the articulating members 158 in the articulated position.
- the obturator 168 may also be locked in place by an obturator locking mechanism actuated by an obturator locking actuator 186 .
- the obturator 168 would be locked in place prior to the sheath 150 to hold the sheath in the desired orientation. Once the sheath 150 is then locked, the obturator 168 may be unlocked and removed.
- actuators 170 , 172 , 174 , 180 , 186 and any additional actuators located on the handles 160 , 176 may take any suitable form including knobs, buttons, levers, switches, toggles, sensors or other devices.
- the handles 160 , 176 may include a numerical or graphical display of information such as data indicating the articulated position of the sheath 150 and/or obturator 168 .
- FIGS. 13 A- 13 D illustrate a method of using the access system 148 for accessing the mitral valve MV.
- the access system 148 may be tracked from a puncture in the femoral vein, through the interior vena cava and into the right atrium. This may be facilitated by the use of a guidewire that is first inserted through the vasculature into the heart, and sheath 150 and obturator 168 are then slidably introduced over the guidewire.
- obturator 168 will have a guidewire lumen for this purpose as described above. As shown in FIG.
- the access system 148 is then punctured through a fossa F in the intra-atrial septum S.
- Obturator 168 may further have a distal tip configured to penetrate the inter-atrial septum S, or obturator 168 may be removed and a separate penetration tool may be inserted though the access sheath 150 .
- the guidewire may have a tip suitable for penetrating the inter-atrial septum and the distal tip of obturator 168 may be tapered to facilitate widening the guidewire penetration so as to allow passage of sheath 150 .
- the system 148 is then advanced through the fossa F so that the distal tip 155 is directed over the mitral valve MV.
- this approach serves merely as an example and other approaches may be used, such as through the jugular vein, femoral artery, port access or direct access, to name a few. It may also be appreciated that the sheath 150 and obturator 168 of the system 148 may alternatively be advanced in separate steps.
- a primary curve 200 may be formed due to actuation of the obturator 168 , as described above.
- the obturator 168 applies forces to the central lumen 156 to reposition the articulating members 158 .
- formation of the primary curve 200 moves the distal tip 155 within a primary plane, corresponding to previous plane X in FIG. 2A, parallel to the valve surface.
- the access sheath 150 is shown in an articulated position which includes a secondary curve 202 in a secondary plane, corresponding to previous plane Z in FIG. 2B. Formation of the secondary curve 202 moves the distal tip 15 vertically and angularly between the commissures C, directing the central lumen 156 toward the mitral valve MV. In this articulated position an interventional device which is passed through the central lumen 156 would be directed toward and/or through the opening 60 .
- the primary curve 200 and the secondary curve 202 may be varied to accommodate different anatomical positions of the valve MV and different surgical procedures, further adjustment may be desired beyond these two curvatures for proper positioning of the access sheath 150 .
- the access sheath 150 may include additional curvatures throughout the articulating members 158 and/or allow the distal tip 155 to move angularly through an angle theta 204 by action of the obturator 168 .
- This moves the tip 155 vertically and angularly through a theta plane, corresponding to previous plane Y in FIGS. 2 C- 2 D. Movement of the distal tip 155 through the angle theta 50 in either direction is shown in dashed line in FIG. 13B. Consequently, the central lumen 156 can be directed toward the mitral valve MV within a plane which differs from the secondary plane.
- the access sheath 150 will be in an articulated position which positions the distal tip 15 so that the opening of the central lumen 156 at the tip 155 faces the desired direction.
- the articulating members 158 are then locked in place by a locking feature, such as by activation of a locking mechanism.
- the obturator 168 is then removed while the sheath 150 remains in the articulated position.
- the locked access sheath 150 allows for the passage of interventional devices 70 , as illustrated in FIG. 13D.
- the interventional device 70 can be passed through the central lumen 156 toward the target tissue, in this case the mitral valve MV.
- Positioning of the distal end 155 over the opening 60 allows the device 70 to pass through the opening 60 between the leaflets LF if desired, as shown.
- any desired surgical procedure may be applied to the mitral valve for correction of regurgitation or any other disorder.
- the mitral valve is repaired using a “bow-tie” or “edge-to-edge” technique with devices introduced through the access sheath of the invention.
- Suitable devices and techniques are described in copending U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001400US), U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001500US), and U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001700US), filed on the same day as the present application, which have been incorporated herein by reference.
- Other procedures that may be performed using devices introduced through the access sheath of the invention include ablation of the pulmonary veins for treatment of atrial fibrillation, mapping and ablation of other regions in or on the heart, annuloplasty of the mitral valve, repair of other heart valves, repair of septal defects, and other diagnostic and therapeutic procedures in the heart.
- the access sheath of the invention is further suitable for accessing and performing procedures on other organs of the body either intraluminally or via surgical penetrations, including stomach, intestines, bowel, bladder, lungs, liver, gall bladder, uterus, and others.
- both the obturator 168 and the sheath 150 are independently steerable.
- the obturator 168 and sheath 150 can be shaped or articulated by any suitable mechanism, such as pullwires which extend through the obturator 158 and separate pullwires which extend through the sheath 150 and can be manipulated to create bends, arcs, curves or angles.
- the sheath 150 and obturator 168 can be moved into articulated positions similar to those shown in FIGS. 2 A- 2 D.
- kits 300 comprise any of the components described in relation to the present invention.
- the kit 300 comprises an articulatable access sheath and instructions for use IFU.
- the kit 300 comprises an access sheath 150 , an articulatable obturator 168 and instructions for use IFU.
- any of the kits may further include any of the other system components described above, such as an interventional device 70 , or components associated with positioning a device in a body lumen, such as a guidewire 302 or needle 304 .
- the instructions for use IFU will set forth any of the methods as described above, and all kit components will usually be packaged together in a pouch 305 or other conventional medical device packaging.
- kit components which will be used in performing the procedure on the patient will be sterilized and maintained within the kit.
- separate pouches, bags, trays or other packaging may be provided within a larger package, where the smaller packs may be opened separately to separately maintain the components in a sterile fashion.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Plasma & Fusion (AREA)
- Otolaryngology (AREA)
- Surgical Instruments (AREA)
- Endoscopes (AREA)
Abstract
Description
- This application is a continuation-in-part of, and claims the benefit of priority from co-pending U.S. patent application Ser. No. 09/894,463, filed Jun. 27, 2001, which is a continuation-in-part of co-pending U.S. patent application Ser. No. 09/544,930, filed Apr. 7, 2000, which claims the benefit of prior Provisional Application No. 60/128,690, filed on Apr. 9, 1999 under 37 CFR §1.78(a), the full disclosures of which are hereby incorporated herein by reference. This application is related to U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001400US), U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001500US), and U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001700US), all of which are filed on the same day as the instant application, the full disclosures of which are incorporated herein by reference.
- NOT APPLICABLE
- NOT APPLICABLE
- 1. Field of the Invention
- The present invention relates to an access sheath for endoluminally accessing a body cavity and directing the passage of interventional devices therethrough into the cavity. Particularly, the present invention relates to an articulatable access sheath which directs the interventional devices into the cavity in a desired orientation. In some embodiments, the present invention relates to vascularly accessing an atrium of the heart to direct an interventional catheter toward a cardiac valve.
- To access a target location within the human body from a remote location, a catheter is typically passed through one or more body lumens, such as through the vascular system, to the target location. When the vascular system is used, a guidewire and dilator is inserted into an artery or vein through a relatively small incision in the patient's body. The guidewire and dilator is then threaded through the patient's vasculature to reach the desired target area. Often the dilator is covered by a sheath which is passed with the dilator to the target location. The dilator is then removed and the sheath is used as a conduit for access for a variety of medical devices to access the target location. Such devices may include catheters, surgical instruments, fiber optic cables for visualization, lasers, electronic devices, or sensors capable of monitoring physiological parameters in situ, to name a few. Although such access reduces the need for traditional invasive surgery, challenges arise related to control, manipulation, and positioning of instruments near the target location, particularly within a target body cavity.
- A device advanced to the cavity will typically protrude into the cavity at the angle in which it entered. If the target tissue is not within this pathway, the device will need to be steered toward the target tissue. If more than one device is used during a procedure, each device will need to be steered and repositioned when used. This increases the time and cost of the procedure and also the risk of misalignment.
- For example, to gain access to the left atrium of the heart, the catheter and/or access sheath may be tracked from a puncture in the femoral vein, through the inferior vena cava, into the right atrium and through a puncture in the intra-atrial septum to the left atrium. This pathway may then be used to access the mitral valve which lies between the left atrium and the left ventricle. From the point of entry through the septum, the mitral valve may be located below and to the right or left requiring the devices which are inserted to be directed downward and perhaps laterally after entry, toward the mitral valve. In addition, devices used for applying interventional therapies to the mitral valve may require precise alignment with the valve commissures, leaflets, or coaptation line to perform the procedure. When such procedures require the use of more than one instrument, each instrument would be dependent upon proper positioning in relation to the valve. This would require that positioning or steering mechanisms be built into each instrument and each instrument would be required to be properly positioned when introduced. This adds cost, complexity, and time to the overall procedure.
- To overcome some of these challenges, access sheaths have been developed to direct instruments that are passed therethrough. For example, an access sheath having a pre-shaped curve at its distal end has been developed to both assist in negotiating twists and branches common in a patient's arterial or venous system and to maintain a shape once positioned within a target cavity. Since the pre-shaped curve is fixed into the access sheath at the time of manufacture, the radius and extent of the curvature generally cannot be altered. Due to anatomical variations, extensive presurgical planning would be necessary to determine the correct curvature of the access sheath. Such tailoring would be prohibitively complex and a predicted curvature would most likely still require additional repositioning once inside the body. Continuously replacing the pre-shaped access catheter in hopes of obtaining the proper curvature would be expensive and time consuming, possibly placing the patient at additional risk.
- Steerable guide catheters and delivery catheters have been developed to more effectively navigate through the tortuous pathways of some body lumens, particularly the vascular system. Typically steering is accomplished through a combination of torqueing the proximal end of the catheter and pulling various pullwires to deflect the distal end of the catheter. Unfortunately, torque transmission has not been perfected in such steerable catheters. Due to the length of the catheter body between a proximal control end and the distal tip, torsion can tend to accumulate as the proximal end of the catheter is twisted to rotate the tip. The accumulated torsional moment may release unevenly, resulting in skipping or rapid rotation of the distal tip inside the vessel. To optimize torque transmission, the walls of such steerable catheters generally comprise a series of layers. In a typical steerable catheter, a woven metal or polymeric tubular braid may be sandwiched between an inner tubular sleeve and an outer tubular jacket. As a consequence, improved torquability generally results in increased wall thickness, which in turn increases the outside diameter of the steerable catheter or reduces any given desired inside diameter. In addition, such a heavy braided construction is often difficult to deflect by actuation of pullwires. To overcome this, the deflectable section can be softened with coils or softer polymers to allow it to be deflected to a much greater extent. However, this reduces the catheter's ability to transmit torque to or through this softer section. In addition, these softer sections may not offer adequate support for interventional devices or tools which are later passed through its inner lumen.
- For these reasons, it would be desirable to provide an access sheath having an articulatable distal end which does not rely on permanent pre-shaping or torque transmission for positioning the access sheath within a target body cavity in a desired orientation. The articulatable access sheath should have a large lumen diameter to accommodate the passage of a variety of interventional devices, should have good wall strength to avoid kinking or collapse of the sheath when bent around tight curves, and should have good column and tensile strength to avoid deformation when the interventional devices are passed through the lumen. The sheath articulation mechanisms should provide for a high degree of controlled deflection at the distal end of the sheath but should not take up significant lumen area to allow for passage of interventional devices. Further, the access sheath should be articulatable in a manner which allows compound curves to be formed, for example curvature within more than one plane. Such manipulation should allow fine control over the distal end to accommodate anatomical variations within the same type of body cavity and for use in different types of body cavities.
- 2. Description of the Background Art
- Hermann et al. (U.S. Pat. No. 5,843,031) describes a large-diameter introducer sheath having a hemostasis valve and a removable steering mechanism. The steering mechanism is described to be within an obturator which is positioned within the sheath during positioning and is then removable. Adair (U.S. Pat. No. 5,325,845) describes a steerable sheath having an articulatable member which is deformable to allow articulation. Kordis (U.S. Pat. No. 5,636,634) describes a sheath which is positioned by a separate, dedicated steering catheter.
- A number of the other references refer to guidewires or catheters which themselves are steerable by means of wires. For example, Stevens-Wright et al. (U.S. Pat. No. 5,462,527) describes a handle which applies tension selectively to two or four pull cables to steer an attached catheter. Stevens-Wright et al. (U.S. Pat. No. 5,715,817) further describes improvements in actuating the tip of the catheter described in Stevens-Wright et al. '527.
- Hammerslag (U.S. Pat. No. 5,108,368) describes a steerable guidewire or catheter wherein the tip is deflectable through a full 360 degree range of motion by means of axially moveable deflection wires extending throughout. Hammerslag (U.S. Pat. No. 5,820,592) describes a guide catheter through which a torque control wire or a deflection wire extends. Manipulating an actuator controls the wire to steer or aim the guide catheter. Savage (U.S. Pat. No. 5,368,564) and Savage et al. (U.S. Pat. No. 5,507,725) also describe a steerable catheter having wire members extending through the catheter wall to manipulate the tip.
- Likewise, the following also provide variations of the steerable catheters which utilize wires for manipulation: Accisano, III (U.S. Pat. No. 5,571,085), Krauter (U.S. Pat. No. 5,359,994), West et al. (U.S. Pat. No. 5,318,525), Nardeo (Pub. No. US 2001/0037084 A1), Bumbalough (U.S. Pat. No. 6,267,746), Webster, Jr. (U.S. Pat. No. 6,123,699), Lundquist et al. (U.S. Pat. No. 5,195,968) and Lundquist et al. (U.S. Pat. No. 6,033,378). Falwell et al. (U.S. Pat. No. 6,319,250) describes a catheter having any suitable steering mechanism known in the art.
- The present invention provides devices, systems, methods and kits for endoscopically accessing a body cavity and providing a directed pathway toward a target tissue within the cavity. The directed pathway is provided by an access sheath which is positioned in a desired configuration, generally directed toward the target tissue. Interventional devices may then be passed through the sheath to the target tissue. Depending on the location of the target tissue and the desired angle of approach, the access sheath may be required to maintain one or more curves in one or more planes to properly direct the interventional devices. The access sheath of the present invention has a portion which comprises a series of articulating members to allow the sheath to form these curvatures. In addition, the access sheath has a locking feature to hold the articulating members in place and maintain the desired configuration. The articulating members may be positioned by an articulating mechanism within the sheath, such as pullwires which extend through at least one of the articulating members. Or, an articulatable obturator may be positioned within the sheath, wherein articulation of the obturator in turn moves the encasing sheath into the desired articulated position. The obturator is then removed and the sheath remains in the articulated position. Thus, the present invention allows the target tissue to be repeatedly accessed through the access sheath without the need to incorporate steering mechanisms into each interventional device or the need to spend additional time repositioning each interventional device upon use.
- In a first aspect of the present invention, an articulatable access sheath is provided for accessing the body cavity. The access sheath comprises a shaft having a proximal end, a distal end and a central lumen therethrough. The distal end is sized appropriately for the intended method of approaching the body cavity. The body cavity may be approached laparoscopically, thorascopically, endoscopically, endovascularly, percutaneously or by any suitable method. Preferably, the distal end of the access sheath is passable through a body lumen, such as a blood vessel within the vascular system. This is particularly the case when approaching a chamber of the heart, which can be accessed either through the femoral vein and inferior vena cava or the superior vena cava into the right atrium, or through a femoral or axillary artery and the aorta into the left ventricle. The distal end may further be configured to penetrate the interatrial septum so as to be passed from the right atrium to the left atrium. Other body lumens through which the device may be positioned include the esophagus for approaching the stomach, the colon for approaching the gastrointestinal system, the trachea for approaching the lungs, or the urethra for approaching the urinary tract. In other instances, the distal end of the access sheath is passable directly through body tissues, such as in a direct access procedure to the heart. The access sheath may be positioned in a penetration in the chest wall and used to access the outside of the heart to perform diagnostic and interventional procedures such as ablation of the pulmonary veins to treat atrial fibrillation. Alternatively, the sheath may be passed through the wall of the heart to access the interior chambers thereof. The central lumen extends through the length of the shaft and is sized for passage of an interventional device, such as a catheter or tool, to perform procedures such as valve repair, electrophysiological mapping and ablation, and septal defect repair. To accommodate a variety of interventional devices, the central lumen is generally relatively large in comparison to the total cross section of the shaft.
- The shaft also includes a portion which comprises a series of articulating members. The articulating members may have any suitable shape, however in preferred embodiments the members comprise interfitting domed rings. The ring aspect provides a hollow interior which forms the central lumen. The dome aspect provides a surface which is rotateable against an interfitting surface of an adjacent domed ring. Since the domed rings are individually rotateable, the series of articulating members can be positioned in a variety of arrangements to follow any pathway. Typically, the portion of the shaft comprising the series of articulating members is the distal end. This is because the distal end is usually advanced into the body cavity and benefits from articulation to properly direct interventional devices which are passed through. However, it may be appreciated that the articulating portion may be disposed at any location along the shaft and more than one portion having a series of articulating members may be present.
- In some embodiments, the sheath includes at least one pullwire to articulate the articulating members. The pullwires extend through at least one of the articulating members to move the portion of the shaft having the articulating members into an articulated position. The pullwires can extend through the central lumen or through individual lumens in the walls of the articulating members. It may be appreciated that more than one pullwire may extend through any given lumen. To provide optimal positioning of the shaft, a plurality of pullwires are present at locations around the perimeter of the central lumen. The presence of each pullwire allows articulation of the shaft in the direction of the pullwire. For example, when pulling or applying tension to a pullwire extending along one side of the shaft, the shaft will bend, arc or form a curvature toward that side. To then straighten the shaft, the tension may be relieved for recoiling effects or tension may be applied to a pullwire extending along the opposite side of the shaft. Therefore, pullwires can be symmetrically placed along the sides of the shaft. Although any number of pullwires are possible, generally, four to eight pullwires are preferred.
- Each pullwire is attached to the shaft at a location chosen to result in particular curvature of the shaft when tension is applied to the pullwire. For example, if a pullwire is attached to the most distal articulating member in the series, applying tension to the pullwire will compress the articulating members proximal to the attachment point along the path of the pullwire. This results in a curvature forming in the direction of the pullwire proximal to the attachment point. It may be appreciated that the pullwires may be attached to any location along the shaft and is not limited to attachment to articulating members.
- When more than one curvature is desired, pullwires are attached at various attachment points, each attachment point providing a different curvature or altering the overall articulated position of the sheath. For example, when a first pullwire is fixedly attached to the shaft at a primary attachment point, applying tension to the first pullwire arcs the series of articulating members proximal to the primary attachment point to form a primary curve. If the distal end terminates in a distal tip and the primary attachment point is located at the distal tip, the primary curve will extend through the entire series of articulating members. If the primary attachment point is located mid-way along the series of articulating members, the primary curve will extend through the series of articulating members proximal to the primary attachment point. When a second pullwire is fixedly attached to the shaft at a secondary attachment point, applying tension to the second pullwire arcs the series of articulating members proximal to the secondary attachment point to form a secondary curve. The primary and secondary curves may lie in the same plane or in different planes. In some embodiments, the planes are substantially orthogonal.
- In some embodiments, a third pullwire is fixedly attached to the shaft at a distal attachment point and applying tension to the third pullwire moves the distal end through an angle theta. In particular, when the distal attachment point is located near the distal tip, the third pullwire moves the distal tip through the angle theta. The angle theta will be described and illustrated in more detail in later sections. However, the angle theta generally serves to tip or angle the distal tip in relation to a center line to further refine the articulated position of the sheath. Often the angle theta lies in a plane which is different from at least the primary curve or the secondary curve and sometimes both. In fact, the angle theta may lie in a plane which is orthogonal to both the primary curve and the secondary curve.
- Tension is applied to the pullwires by manipulation of actuators located on a handle. The handle is connected with the proximal end of the articulatable access sheath and remains outside of the body. The actuators may have any suitable form, including buttons, levers, knobs, switches, toggles, dials, or thumbwheels, to name a few. Each actuator may apply tension to an individual pullwire or to a set of pullwires, or may actuate the articulation element according to its type. Generally, a different actuator is used to form each curvature, such as the primary curvature and secondary curvature, and to cause movement through the angle theta. The handle may also include a locking actuator to actuate a locking mechanism.
- Locking holds the articulating members in the articulated position. By such locking, the sheath is maintained in the articulated position while interventional devices are passed therethrough. The sheath will retain sufficient rigidity to deflect and guide a non-steerable interventional device through its central lumen and direct the device to the body cavity, particularly to the target tissue within the body cavity. In some embodiments, the locking feature comprises sufficient friction between articulating members so that the members are held in place, either by friction of one articulating member against another or by the presence of frictional elements between the articulating members. In other embodiments, the locking feature comprises a locking mechanism which includes a mechanism for holding at least one of the pullwires in the tensioned position. As described previously, tensioning of a pullwire typically draws a portion of the articulating members together, forming a curve. By holding the pullwire in this tensioned position, the articulated members can often maintain this arrangement. By holding more pullwires in place, the ability to maintain the arrangement is increased. Therefore, some locking mechanisms will hold all of the pullwires in a tensioned position. When individual pullwires control individual portions of the series of articulated members, the portions may be individually locked by holding tension in the appropriate pullwires. This may be useful, for example, when a desired primary curve is established and a secondary curve is undertaken. The primary curve may be locked in place prior to creating the secondary curve to allow independent creation of each curve.
- Although only a few types of curves have been described in relation to the articulated position, it may be appreciated that any number of curves or shapes may be formed throughout the series of articulating members. In addition, permanent curves may also be provided throughout the portion of the shaft comprising the series of articulating members. Such permanent curves may be a result of the shapes of the articulating members, the way in which the articulating members are arranged or fit together, or of any other mechanism. Further, any number of curves or shapes may be pre-formed throughout portions of the shaft other than the portion of the shaft comprising the series of articulating members. And, alternative articulation elements may also be used, such as pushrods, thermally-controlled shape memory alloy wires, or hydraulic or pneumatic fluids, to name a few.
- In a second aspect of the present invention, an access system for accessing a body cavity is provided. The access system comprises a sheath which includes a shaft having a proximal end, a distal end and a central lumen therethrough. Again, the distal end is sized appropriately for the intended method of approaching the body cavity. And, a portion of the shaft comprises a series of articulating members which are lockable in a fixed position. The access system further comprises an obturator sized for passage through the central lumen and having means for articulating the obturator. Articulation of the obturator positions the articulating members of the sheath in an articulated position which becomes the fixed position upon locking. The obturator is then removed so that interventional devices may be passed therethrough.
- The portion of the shaft comprising the series of articulating members may be the same or similar to that described above in relation to the articulatable access sheath. Again, in preferred embodiments the articulating members comprise interfitting domed rings, each domed ring independently rotateable against an adjacent domed ring. And, pullwires may be present which pass through the at least one of the articulating members. However, in this embodiment, the pullwires are not used to position the articulating members, rather the pullwires are used to lock the articulating members in the fixed position. In some embodiments, the pullwires hold the articulating members in contact with enough frictional force to hold or lock the articulating members in the fixed position. In other embodiments, tension may be applied to some or all of the pullwires to further wedge the articulating members together and therefore lock them in place.
- The articulating members are moved into the articulated position by action of the obturator. Once the obturator has been placed within the central lumen of the shaft, the obturator can be moved into any arrangement. For example, the obturator may be shaped to have bends, arcs, curves or angles. Such shaping can be achieved by any suitable mechanism, including pullwires which act similarly to those described above in relation to articulating the articulatable access sheath. The shaping of the obturator applies forces to the central lumen and transfers the shaping to the surrounding sheath. Again, the articulated position can include any number of curves, including a primary curve, secondary curve or angle theta, to name a few. And, the curves may lie in the same or different planes.
- Articulation of the obturator can be achieved by manipulation of actuators located on an obturator handle. The obturator handle is connected with the proximal end of the obturator and remains outside of the body. Again, the actuators may have any suitable form, including buttons, knobs, switches, toggles, dials, or thumbwheels, to name a few. Each actuator may apply tension to an individual pullwire or to a set of pullwires. Generally, a different actuator is used to form each curvature, such as the primary curvature and secondary curvature, and to cause movement through the angle theta. The obturator handle may also include an obturator locking actuator to actuate an obturator locking mechanism.
- The obturator locking mechanism locks the obturator in the articulated position. By such locking, the obturator is maintained in the articulated position while the sheath is then locked in position. In some embodiments, the locking mechanism of both the obturator and sheath include a mechanism for holding at least one of the pullwires in the tensioned position. Some locking mechanisms will hold all of the pullwires in a tensioned position. When individual pullwires affect individual portions of the obturator or the series of articulated members, the portions may be individually locked by holding tension in the appropriate pullwires.
- Again, although only a few types of curves have been described in relation to the articulated position, it may be appreciated that any number of curves or shapes may be formed throughout the obturator. In addition, permanent curves may also be pre-set throughout obturator, such as by heat-setting. These permanent curves will then also be transferred to the surrounding sheath.
- After the sheath has been locked in place, the obturator can then be unlocked and removed. Or, when the obturator has a permanent heat-set curve, the locked sheath will be sufficiently rigid enough to allow removal of the pre-curved obturator without changing the shape of the sheath. The sheath will also retain sufficient rigidity to deflect and guide a non-steerable interventional device through its central lumen and direct the device to the body cavity, particularly to the target tissue within the body cavity.
- In other embodiments, the obturator may only form a single curve yet may be used to form compound or multiple curves in the sheath. For example, the obturator may be positioned in a first location along the sheath forming a first curve. The sheath is then locked in place in this first location to hold the first curve. The obturator may then be positioned in a second location along the sheath forming a second curve. Likewise, the sheath is then locked in the second location to hold the second curve. Hence, multiple or compound curves may be formed from an obturator capable of forming a single curve. This concept may be extrapolated to cover obturators capable of forming more than a single curve yet are used to form curves in sheath which are more complex or of a higher number.
- In a third aspect of the present invention, methods of accessing a body cavity are provided. In one embodiment, the method includes advancing a sheath through a body lumen to the body cavity, wherein the sheath includes a shaft having a proximal end, a distal end, a central lumen therethrough, and a portion of the shaft comprises a series of articulating members. Although the sheath can be used to access any body cavity through any pathway, such as laparoscopically, thorascopically, endoscopically, endovascularly or percutaneously, the sheath may particularly be used to access one or more chambers of the heart. The chambers of the heart provide access to many tissues which may be targeted for treatment, such as valves, chordae tendinae, papillary muscles, the Purkinje system, pulmonary veins and coronary arteries, to name a few. When targeting the mitral valve, the left atrium may be accessed to approach the valve from above. To accomplish this, the sheath may be advanced through the vasculature to the right atrium and passed through the intra-atrial septum to the left atrium. The articulating members are then articulated to move the portion of the shaft comprising the series of articulating members into an articulated position. It may be appreciated that the mitral valve may alternatively be approached from below or from the ventricular side by accessing the left ventricle. This is typically achieved by advancing the sheath through the vasculature to the aorta, through the aortic valve and into the left ventricle. Examples of this approach and other approach methods are provided in U.S. Patent application Ser. No. 09/894,463 (Attorney Docket No. 020489-000400US) filed on Jun. 27, 2001 incorporated by reference herein for all purposes. In a further alternative approach, the access sheath may be positioned through a surgical penetration in the chest wall and through a penetration in a wall of the heart to access the cardiac chambers. Preferably, for mitral valve and other procedures in the left side of the heart, the access sheath is introduced into the right atrium and then advanced across the interatrial septum into the left atrium.
- As described previously, the articulated position may include any number of curves or shapes to properly direct the sheath toward the target tissue. When targeting the mitral valve via the right atrium, the distal end of the sheath extends into the open space of the right atrium. To direct the distal tip of the sheath toward the mitral valve, the sheath may be articulated to move the distal tip laterally, vertically, or angularly, to name a few. For example, the articulated position may include a primary curve in a primary plane parallel to the valve surface. This moves the distal tip laterally in relation to the valve. The articulated position may further include a secondary curve in a secondary plane; typically the secondary plane is different from the primary plane and optionally substantially orthogonal to the primary plane. This moves the distal tip vertically and angularly, directing the central lumen toward or away from the valve along the secondary plane. In addition to these or additional curves, the articulated position may further include an angle theta. This moves the distal end vertically and angularly through a plane which differs from the secondary plane. Consequently, the central lumen can be directed toward or away from the valve along a theta plane which is different than the secondary plane and optionally the primary plane.
- Articulating the articulating members may be accomplished by any of the means described above. For example, the sheath may further comprise at least one pullwire which extends through at least one of the articulating members. Applying tension to the at least one pullwire would thus articulate the articulating members. Once the articulating members are moved into a desired articulated position, the articulating members are locked in place. Locking the articulating members may comprise holding the tension in the at least one pullwire with a locking mechanism. As described previously, locking may be accomplished by holding tension in all of the pullwires.
- Once the sheath is locked in the articulated position, interventional devices are then passed through the central lumen, wherein the articulated position directs the interventional device into the body cavity. In this example, an interventional catheter or tool is passed through the central lumen into the left atrium and directed toward the mitral valve. Depending on the direction provided by the sheath, the interventional device may optionally be advanced through the valve, between the leaflets. The desired surgical procedure can then be performed. If additional catheters or tools are needed, the devices may easily be interchanged by removing one and advancing another while the sheath remains in the articulated position.
- In another embodiment, the method includes advancing a sheath through a body lumen to a body cavity, wherein the sheath comprises a shaft having a proximal end, a distal end, a central lumen therethrough and a portion of the shaft comprises a series of articulating members. However, in embodiment the method includes passing an obturator through the central lumen and articulating the obturator to position the articulating members in an articulated position. The obturator may be articulated by any of the means described previously. The articulated members are then locked in the articulated position and the obturator is removed to allow passage of an interventional device through the central lumen, wherein the articulated position directs the device into the body cavity.
- In a fourth aspect of the present invention, the devices, systems and methods of the present invention may be provided in one or more kits for such use. The kits may comprise an access sheath and instructions for use. The access sheath may be articulatable by means of mechanisms incorporated in the sheath, or the kit may include an articulatable obturator for use in articulating the sheath. Optionally, such kits may further include any of the other system components described in relation to the present invention and any other materials or items relevant to the present invention.
- Other objects and advantages of the present invention will become apparent from the detailed description to follow, together with the accompanying drawings.
- FIG. 1 is a perspective view of an embodiment of an articulatable access sheath of the present invention.
- FIGS.2A-2D illustrate examples of articulated positions of the access sheath.
- FIG. 3 is a perspective side view of an access sheath having an additional curve compared to the articulated positions shown in FIGS.2A-2D.
- FIGS.4A-4C illustrate a method of using the access sheath for accessing the mitral valve.
- FIG. 5 is a perspective view of the portion of the sheath comprising a series of articulating members.
- FIGS.6A-6C are side views of articulating members having different types of inner surfaces.
- FIGS.7A-7D illustrate an embodiment of an articulating member which accommodates four pullwires.
- FIGS.8A-8D illustrate an embodiment of an articulating member which accommodates eight pullwires.
- FIGS.9A-9D illustrate an embodiment of an articulating member which accommodates eight pullwires yet has an inner surface which differs from the embodiment shown in FIGS. 8A-8D.
- FIGS.10A-E illustrate an embodiment of an articulating member which is designed to reduce possible binding of the pullwires and to increase stability of curves during articulation.
- FIG. 11A illustrates various liners which comprise some embodiments of the access sheath.
- FIG. 11B is a perspective view of an embodiment of an access sheath wherein various pullwires are attached to the shaft at various attachment points.
- FIG. 12 is a perspective view of an embodiment of an access system of the present invention.
- FIGS.13A-13D illustrate a method of using the access system for accessing the mitral valve.
- FIG. 14 illustrates a kit constructed in accordance with the principles of the present invention
- Articulatable Access Sheath
- Referring to FIG. 1, an embodiment of an
articulatable access sheath 10 of the present invention is illustrated. Thesheath 10 comprises ashaft 11 having aproximal end 12, adistal end 14, and acentral lumen 16 therethrough. Thedistal end 14 is sized to be passable through a body lumen to a body cavity. Therefore, thedistal end 14 preferably has an outer diameter in the range of approximately 0.040 in. to 0.500 in., more preferably in the range of 0.130 in. to 0.300 in. Thecentral lumen 16 is sized for passage of an interventional device therethrough. Therefore, thecentral lumen 16 preferably has an inner diameter in the range of approximately 0.030 in. to 0.450 in., more preferably in the range of 0.120 in. to 0.250 in. In addition, a portion of theshaft 11 is comprised of a series of articulatingmembers 18. In this embodiment, the articulatingmembers 18 are shown disposed at thedistal end 14 of theshaft 11, terminating in adistal tip 15. Here, the articulatingmembers 18 extend over the distal most 1 to 10 cm of thesheath 10. However, it may be appreciated that the articulatingmembers 18 may be disposed at any location along the sheath. For example, if a straight or non-articulating portion is desired near thedistal end 14, the articulatingmembers 18 may be located at a more proximal position. - The portion of the
shaft 11 having the articulatingmembers 18 is movable into an articulated position by actuation of one or more positioning mechanisms. Actuation of the positioning mechanisms is achieved with the use of actuators, such asactuators handle 20. Thehandle 20 is connected to theproximal end 12 of theshaft 11 and remains outside of the patient's body during use.Actuators shaft 11 comprising articulatingmembers 18. For example, aprimary curve actuator 22 can be used to actuate one or more pull wires to form a primary curve in the portion of theshaft 11 comprising the series of articulatingmembers 18. Further, asecondary curve actuator 24 can be actuated to form a secondary curve in the portion of theshaft 11 comprising the series of actuatingmembers 18. And atheta actuator 26 can be manipulated to move thedistal tip 15 through an angle theta. In addition, a lockingactuator 28 may be used to actuate a locking mechanism to lock the articulatingmembers 18 in the articulated position.Actuators actuator 28 is illustrated as a rotating knob. It may be appreciated thatsuch actuators handle 20 may take any suitable form including knobs, buttons, levers, switches, toggles, sensors or other devices. In addition, thehandle 20 may include a numerical or graphical display of information such as data indicating the articulated position of thesheath 10. - Example Articulated Positions
- FIGS.2A-2D illustrate examples of articulated positions that the articulating
members 18 of theaccess sheath 10 may hold. Referring to FIG. 2A, the articulatingmembers 18 are configured to allow movement into an articulated position which includes aprimary curve 40. Theprimary curve 40 typically has a radius of curvature 42 in the range of approximately 0.125 in. to 1.000 in., preferably in the range of approximately 0.250 in. to 0.500 in. As shown, when the articulated position includes only aprimary curve 40, the articulatingmembers 18 lie in a single plane X. An axis x, transversing through the center of thecentral lumen 16 at thedistal tip 15, lies within plane X. - Referring to FIG. 2B, the articulating
members 18 may further be configured to so that the articulated position further includes asecondary curve 46. Thesecondary curve 46 typically has a radius ofcurvature 48 in the range of approximately 0.050 in. to 0.750 in., preferably in the range of approximately 0.125 in. to 0.250 in. Thesecondary curve 46 can lie in the same plane as theprimary curve 40, plane X, or it can lie in a different plane, such as plane Z as shown. In this example, plane Z is substantially orthogonal to plane X. Axis z, transversing through the center of thecentral lumen 16 at thedistal tip 15, lies within plane Z. By comparing axis x to axis z, the movement of thedistal tip 15 may be compared. Adjustment of the articulatingmembers 18 to include thesecondary curve 46 directs thecentral lumen 16 downward, as shown, along axis z. In this example, axis x and axis z are at substantially 90 degree angles to each other; however, it may be appreciated that axis x and axis z may be at any angle in relation to each other. Also, although in this example theprimary curve 40 and thesecondary curve 46 lie in different planes, particularly in substantially orthogonal planes, thecurves members 18 may be further manipulated to allow thedistal tip 15 to move through anangle theta 50. Theangle theta 50 is in the range of approximately −100° to +100°, preferably in the range of approximately −50° to +50°. As shown, theangle theta 50 lies within a plane Y. In particular, axis y, which runs through the center of thecentral lumen 16 at the distal tip, forms theangle theta 50 with axis z. In this example, plane Y is orthogonal to both plane X and plane Z. Axes x, y, z all intercept at a point within thecentral lumen 16 which also coincides with the intersection of planes X, Y, Z. - Similarly, FIG. 2D illustrates movement of the distal tip through an
angle theta 50 on the opposite side of axis z. Again, theangle theta 50 is measured from the axis z to the axis y, which runs through the center of thecentral lumen 16 at thedistal tip 15. As shown, theangle theta 50 lies in plane Y. Thus, theprimary curve 40,secondary curve 46, andangle theta 50 can all lie in different planes, and optionally in orthogonal planes. However, it may be appreciated that the planes within which theprimary curve 40,secondary curve 46 andangle theta 50 lie may be mutually dependent and therefore would allow the possibility that some of these lie within the same plane. - Further, the articulating
members 18 may be configured to provide additional curves or shapes. For example, as illustrated in FIG. 3, anadditional curve 54 may be formed by the articulatingmembers 18 proximal to theprimary curve 40,secondary curve 46, andangle theta 50. Suchadditional curves 54 may be formed by the articulatingmembers 18 by manipulation of the actuators on thehandle 20, or thecurves 54 may be permanently preformed. Likewise, any number of curves or shapes may be pre-formed throughout portions of the sheath other than the portion of the sheath comprising the series of articulatingmembers 18. In addition or alternatively, pre-formed portions may be intermixed with the portion of the sheath comprising the series of articulatingmembers 18, such as in an alternating pattern. Thus, any number of curves may be formed in theaccess sheath 10 to create the articulated position. - The articulated position of the
access sheath 10 illustrated in FIGS. 2A-2D and FIG. 3 is particularly useful for accessing the mitral valve. FIGS. 4A-4C illustrate a method of using theaccess sheath 10 for accessing the mitral valve MV. To gain access to the mitral valve, theaccess sheath 10 may be tracked from a puncture in the femoral vein, through the interior vena cava and into the right atrium. As shown in FIG. 4A, theaccess sheath 10 may be punctured through a fossa F in the intra-atrial septum S. Theaccess sheath 10 is then advanced through the fossa F so that thedistal tip 15 is directed over the mitral valve MV. Again, it may be appreciated that this approach serves merely as an example and other approaches may be used, such as through the jugular vein, femoral artery, port access or direct access, to name a few. - It is then desired to move and tip the
distal tip 15 so that thecentral lumen 16 is directed toward the target tissue, the mitral valve MV. In particular, thecentral lumen 16 is to be directed toward a specific area of the mitral valve MV, such as toward theopening 60 between the valve leaflets LF, so that a particular interventional procedure may be performed. Aprimary curve 40 may be formed by the series of articulatingmembers 18, as described above. In this example, formation of theprimary curve 40 moves thedistal tip 15 within a primary plane, corresponding to previous plane X, parallel to the valve surface. This moves thedistal tip 15 laterally along the short axis of the mitral valve MV, and allows thedistal tip 15 to be centered over theopening 60. In this articulated position, any interventional devices which are passed through thecentral lumen 16 would be directed horizontally over the valve MV. To direct catheters or tools into theopening 60, it is necessary that thedistal tip 15 is pointed downward towards the mitral valve MV. - Referring to FIG. 4B, the
access sheath 10 is shown in an articulated position which includes asecondary curve 46 in a secondary plane, corresponding to previous plane Z. Formation of thesecondary curve 46 moves thedistal tip 15 vertically and angularly between the commissures C, directing thecentral lumen 16 toward the mitral valve MV. In this articulated position an interventional device which is passed through thecentral lumen 16 would be directed toward and/or through theopening 60. Although theprimary curve 40 and thesecondary curve 46 may be varied to accommodate different anatomical variations of the valve MV and different surgical procedures, further adjustment may be desired beyond these two curvatures for proper positioning of theaccess sheath 10. - Thus, the
access sheath 10 may include additional curvatures throughout the articulatingmembers 18 and/or include the ability of thedistal tip 15 to move angularly through anangle theta 50. This moves the tip vertically and angularly through a theta plane, corresponding to previous plane Y. Movement of thedistal tip 15 through theangle theta 50 in either direction is shown in dashed line in FIG. 4B. Consequently, thecentral lumen 16 can be directed toward the mitral valve MV within a plane which differs from the secondary plane. After such movements, theaccess sheath 10 will be in an articulated position which positions thedistal tip 15 so that the opening of thecentral lumen 16 at thetip 15 faces the desired direction. Once the desired articulated position is achieved, the articulatingmembers 18 are locked in place by a locking feature. The locking feature may simply be the articulating members holding the desired articulated position by friction during the articulation process. In this situation, the members are essentially already locked in place. The locking feature may alternatively be a locking mechanism which is activated, such as simultaneous tensioning of cables to compress the articulation members and locking of the cables in this tensioned position. In any case, such locking provides stiffness in theaccess sheath 10 for the passage ofinterventional devices 70, as illustrated in FIG. 4C. Theinterventional device 70 can be passed through thecentral lumen 16 toward the target tissue, in this case the mitral valve MV. Positioning of thedistal end 15 over theopening 60, as described above, allows thedevice 70 to pass through theopening 60 between the leaflets LF if desired, as shown. At this point, any desired surgical procedure may be applied to the mitral valve for correction of regurgitation or any other disorder. - Articulating Members
- Referring to FIG. 5, a perspective view of the portion of the
shaft 11 comprising a series of articulatingmembers 18 is illustrated. Each articulatingmember 18 may have any shape, particularly a shape which allows interfitting or nesting as shown. In addition, it is desired that eachmember 18 have the capability of independently rotating against an adjacent articulatingmember 18. In this embodiment, the articulatingmembers 18 comprise interfitting domed rings 84. The domed rings 84 each include abase 88 and adome 86. Thebase 88 anddome 86 have a hollow interior which, when thedomed rings 84 are interfit in a series, forms acentral lumen 16. In addition, thedome 86 allows each articulatingmember 18 to mate against an inner surface of an adjacentdomed ring 84.Dome 86 has a convex curvature selected to provide smooth movement and the desired degree of articulation of adjacent domed rings 84. The curvature may be spherical, parabolic, or other rounded shape.Domes 86 could alternatively comprises one or a series of frustoconical surfaces.Base 88 may have a cylindrical, frustoconical, dome-shaped or other suitable external shape. - Also shown in FIG. 5, the interfitting
domed rings 84 are connected by at least onepullwire 80. Such pullwires typically extend through the length of theaccess sheath 10 and at least one of the interfittingdomed rings 84 to a fixation point where thepullwire 80 is fixedly attached to theshaft 11. By applying tension to thepullwire 80, the at least onepullwire 80 arcs the series of interfittingdomed rings 84 proximal to the attachment point to form a curve. Thus, pulling or applying tension on at least one pullwire, steers or deflects theaccess sheath 10 in the direction of thatpullwire 80. By positioningvarious pullwires 80 throughout the circumference of thedomed rings 84, theaccess sheath 10 may be directed in any number of directions. Each interfittingdomed ring 84 may comprise one or morepullwire lumens 82 disposed around the periphery of eachdomed ring 84 through which thepullwires 80 are threaded. Alternatively, thepullwires 80 may be threaded through thecentral lumen 16. In any case, the pullwires are attached to thesheath 10 at a position where a desired curve is to be formed. Thepullwires 80 may be fixed in place by any suitable method, such as soldering, gluing, tying, or potting, to name a few. Such fixation method is typically dependent upon the materials used. The articulatingmembers 18 may be comprised of any suitable biocompatible material including stainless steel, cobalt chromium, titanium, various other metals, ceramics, as well as polymers or co-polymers. Likewise thepullwires 80 may be comprised of any suitable material such as fibers, polymeric monofilament or multifilament line, sutures, metal wires, or metal braids. In a preferred embodiment, wires of Nitinol or stainless steel are utilized. Pullwires 80 may me coated with lubricious coatings such as Parylene to reduce friction. Alternatively, sheaths or eyelets (not shown) of low friction material such as Teflon may be provided inlumens 82 orcentral lumen 16 through which pullwires 80 extend to increase slidability. - In addition, select portions of the articulating
members 18 may be fixed together to create desired curves. For example, when the articulatingmembers 18 comprisedomed rings 84, two, three, four or moredomed rings 84 positioned in a row may be fixed in their interfit positions to prevent movement or rotation between therings 84. This may be achieved by any suitable method such as soldering, gluing, tying, or potting. Such fixing will create segments which cannot be articulated, however articulatingmembers 18 on either side of these segments may be articulated. This may be useful in creating certain curves or shapes, particularly square shapes or sharp angles. It may also be appreciated that these select portions of articulatingmembers 18 may be fixed to form either a straight segment or a curved segment. - Once the
pullwires 80 have been adjusted to obtain a desired articulated position, the series of articulatingmembers 18 may be locked in place to hold theaccess sheath 10 in the desired articulated position. Such locking is achieved by holding most or all of thepullwires 80 simultaneously to force each articulatingmember 18 against its neighboringmember 18. Locking strength is dependent on a number of variables including shape, material, and surface texture of the articulatingmembers 18. As shown in FIGS. 6A and 6B, the interior shapes ofbases 88 anddomes 86 are selected to provide the desired strength of locking, degree of articulation, smoothness of movement, and steerability ofaccess sheath 10. As shown in FIG. 6A, a slopinginner surface 90 may be formed on the interior of thedomed ring 84. As shown in FIG. 6B, a steppedinner surface 92 may be present on the interior of thedomed ring 84. In some cases, the steppedinner surface 92 provides a greater ability to lock tightly, however this may compromise smoothness in steering. As shown in FIG. 6C, a domedinner surface 93 may be present on the interior of thedomed ring 84. To increase the locking ability, outer surfaces of thedome 86 and/or theinner surfaces dome 86 or a frictional spacer may be positioned between domed rings 84. When thedomed rings 84 comprise a metal such as stainless steel, therings 84 may be sandblasted to increase surface roughness. Alternatively a sandpaper or a steel brush may also be used to increase roughness, or the surfaces may be sintered or have grooves or bumps. When thedomed rings 84 comprise an injection molded polymer, a desired roughness may be molded into the surfaces or machined or applied after molding. - A variety of articulation mechanism can be used to articulate the access sheath. In preferred embodiments, pullwires80 are used. Any number of
pullwires 80 may be used to articulate theaccess sheath 10. FIGS. 7A-7D illustrate an embodiment of an articulatingmember 18 which accommodatessuch pullwires 80. FIG. 7A is a cross-sectional view of thebase 88 of the articulatingmember 18. Fourpullwire lumens 82 are shown equally spaced throughout the wall of thebase 88. Such spacing allows curvature of the articulating members in each of the four directions. It may be appreciated that any spacing may be achieved between thepullwire lumens 82 to provide curvature in any desired direction. FIGS. 7B-7C are side views of themember 18 wherein thepullwire lumen 82 is shown to pass through the wall of thebase 88 and part of the wall of thedome 86. In this example, the slopinginner surface 90 is shown, however, it may be appreciated that any inner surface contour may be used. FIG. 7B is a perspective view of the articulatingmember 18 illustrating all fourpullwire lumens 82 passing through thebase 88 and partially through thedome 86. - Similarly, FIGS.8A-8D illustrate an embodiment accommodating eight pullwires. FIG. 8A is a cross-sectional view of the
base 88 of the articulatingmember 18. Eightpullwire lumens 82 are shown equally spaced throughout the circumference of the wall of thebase 88. Such number and arrangement of pullwires provides even greater control of the curvature of the access sheath than the embodiment having four pullwires. Again, the lumens may be spaced, sized and arranged to provide any desired curvature. FIGS. 8B-8C are side views of the articulatingmember 18 having eightpullwire lumens 82. As shown, thepullwire lumens 82 pass through thebase 88 and partially through thedome 86. This embodiment also illustrates a slopinginner surface 90. However, it may be appreciated that any type of inner surface may be used, whether it be stepped, tapered, domed, balled or some combination thereof. Similarly, FIGS. 9A-9D illustrate views of an embodiment of theaccess sheath 10 that includes eightpullwire lumens 82. However, in this case the embodiment shows a steppedinner surface 92 particularly visible in FIGS. 9B-9C. - FIGS.10A-10E illustrate an embodiment of an articulating
member 18 which is designed to reduce any possible binding of the pullwires and to increase stability of curves during articulation. To reduce binding of the pullwires during articulation, oblongpullwire lumens 83 are used. As shown in FIG. 10A, a cross-sectional view of thebase 88 of the articulatingmember 18, fourcircular pullwire lumens 82 are present along with fouroblong pullwire lumens 83. Thelumens base 88. Such spacing allows curvature of the articulating members in each of the four directions. The oblongpullwire lumens 83 allows the pullwires to shift or slide along thelumen 83 to provide more gradual, smoother pathways for the pullwires to follow through the articulatingmembers 18. Oblongpull wire lumens 83 may be of oval, elliptical, arcuate, or a rounded rectangular shape in cross-section, with a length in the circumferential direction substantially longer than the width in the radial direction, usually being at least 1.5 times as long, preferably at least twice as long and in some embodiments at least 3 times as long, and may subtend an arc of at least about 5 degrees, and preferably at least about 20 degrees along the circumference ofmember 18. FIG. 10B is a side view of themember 18 wherein thecircular pullwire lumen 82 is shown to pass through the wall of thebase 88 and part of the wall of thedome 86 and the oblongpullwire lumens 83 are shown on either side of thecircular pullwire lumen 82. In a preferred embodiment, circularpullwire lumens 82 alternate with oblongpullwire lumens 83 around the circumference ofmember 18. In this embodiment,dome 86 preferably is divided into a series of annular sections separated by channels in the outer surface thereof, such that contact betweenadjacent members 18 is limited to the outer surfaces of the annular sections. Some or all of the channels may be axially aligned with oblongpullwire lumens 83. The annular sections ofdomes 86 preferably subtend an angle of between about 10 and 80 degrees, preferably between about 20 and 45 degrees, along the circumference ofmembers 18. - To increase stability of the curves during articulation, pins are used to keep the
members 18 aligned, as illustrated in FIGS. 10C-10E. As shown in FIG. 10C, at least onehole 89 is formed in the wall of thedome 86 and anotch 91 is formed in thebase 88. FIG. 10D provides a perspective view of such ahole 89 and notch 91 in themember 18. Typically, as shown, theholes 89 andnotches 91 are formed in pairs on opposite sides of themember 18. Referring now to FIG. 10E, pins 93 are inserted intoholes 89 and soldered in place.Such pins 93 are typically stainless steel and may have an outer diameter of approximately 0.020 in. and length of approximately 0.030 in. When themembers 18 are assembled and interlocked as shown, thenotches 91 receive thepins 93. Thus, during articulation, the movement ofmembers 18 is limited to rotation about an axis drawn throughpins 93. This stabilizes the device and reduces any rotation in undesired directions. - Liners
- Referring to FIG. 11A, the
access sheath 10 may further comprise various liners which extend through the lumens of the articulatingmembers 18. As shown, abraid 104 may extend through thecentral lumen 16 of theshaft 11. Such a braid may be comprised of stainless steel or any appropriate material. Typically thebraid 104 extends through a length of theshaft 11 to the articulatingmembers 18. Thebraid 104 provides rigidity and torque response of theshaft 11, proximal to the articulatingmembers 18. Therefore, thebraid 104 does not extend within the articulatingmembers 18. Instead, anouter liner 102 andinner liner 100, supported by acoil 101 or similar structure therebetween, extend throughout the length of the articulatingmembers 18. Typically, thecoil 101 is comprised of stainless steel or similar material. In some embodiments, theouter liner 102 comprises 35D PEBAX, PTFE, urethane, nylon or polyethylene, to name a few. However, any suitable polymer may be used. Also, in some embodiments, theinner liner 100 is comprised of PTFE or a similar low friction material.Such liners interventional device 70 to be passed through thecentral lumen 16 without interference with the articulatingmembers 18. In addition,pullwire lumen liners 106 may extend through thepullwire lumens 102 and encapsulate thepullwires 80. Suchpullwire lumen liners 106 may be comprised of a braided polyimide or any suitable material to provide strength, flexibility, and protection of thepullwires 80. Finally, in some embodiments, anexternal liner 105 is positioned over the articulating members and is fused to theinner liner 100 andouter liner 102 at the distal tip. Such anexternal liner 105 may be comprised of any suitable material, such as PEBAX 35D, and is generally for protection and continuity of the articulating members and as a blood barrier. - Articulation
- As described previously, the
pullwires 80 pass through the articulatingmembers 18 and attach to theshaft 11 at various attachment points. Referring to FIG. 11B, afirst pullwire 120 is shown fixedly attached to theshaft 11 at aprimary attachment point 122. Applying tension to thefirst pullwire 120 arcs the series ofarticulation members 18 proximal to theprimary attachment point 122 to form aprimary curve 40. In this example, theprimary attachment point 122 is shown midway along the series of articulatingmembers 18. This provides aprimary curve 40 proximal to thispoint 122. It may be appreciated that theprimary attachment point 122 may be located anywhere along theshaft 11, including at thedistal tip 15. When attached to thedistal tip 15, applying tension to thefirst pullwire 120 would create a primary curve 140 across the entire section of articulatingmembers 18. - In the example illustrated in FIG. 11B, a
second pullwire 124 is shown fixedly attached to theshaft 11 at asecondary attachment point 126. Applying tension to thesecond pullwire 124 arcs the series of articulatingmembers 18 proximal to thesecondary attachment point 126 to form asecondary curve 46. Since thefirst pullwire 120 has already created a primary curve 140 in the proximal section, pulling on thesecond pullwire 124 creates a secondary curve in a section distal to the proximal section. - Further, a
third pullwire 128 may be present which is fixedly attached to theshaft 11 at adistal attachment point 130 so that pulling thethird pullwire 128 moves the distal end through an angle theta 50 (see FIG. 4B). Thus,shaft 11, havingpullwires access sheath 10 to be capable of forming a multitude of curves in several different planes. - Access System
- Referring to FIG. 12, an embodiment of an access system148 of the present invention is illustrated. The access system 148 comprises an
access sheath 150 including ashaft 151 having aproximal end 152, adistal end 154, and acentral lumen 156 therethrough. Thedistal end 154 is sized to be passable through a body lumen to a body cavity. Therefore, thedistal end 14 preferably has an outer diameter in the range of approximately 0.040 in. to 0.500 in., more preferably in the range of 0.130 in. to 0.300 in. In addition, a portion of thesheath 150 is comprised of a series of articulatingmembers 158. In this embodiment, the articulatingmembers 158 are shown disposed at thedistal end 154 of thesheath 150, terminating in adistal tip 155. However, it may be appreciated that the articulatingmembers 158 may be disposed at any location along the sheath. For example, if a straight or non-articulating portion is desired near thedistal end 154, the articulatingmembers 158 may be located at a more proximal position. Further, portions of the sheath having articulatingmembers 158 may be interspersed with non-articulating portions, such as in an alternating pattern. Ahandle 160 is mounted to theproximal end 152 ofsheath 150. The access system 148 further comprises anobturator 168 sized for passage through thecentral lumen 156, as shown. Theobturator 168 preferably has an outer diameter in the range of approximately 0.025 in. to 0.440 in., more preferably in the range of 0.115 in. to 0.240 in. Usually, a hemostasis valve of well-known construction (not shown) will be mounted to or withinhandle 160 in communication withcentral lumen 156 that allowsobturator 168 to be inserted into and removed fromcentral lumen 156 without loss of blood.Obturator 168 may have anaxial lumen 169 through which a guidewire GW may be slidably inserted to facilitate guiding access system 148 through the vasculature. If such a guidewire lumen is present,obturator 168 will usually also include a hemostasis valve HV mounted to handle 170 in communication with the guidewire lumen to allowobturator 168 to be slidably introduced over guidewire GW and to allow guidewire GW to be removed fromlumen 169 without loss of blood. Guidewire GW, which may be any of various commercially available guidewires, may optionally be included in the system and kits of the invention. - The articulating
members 158 of theaccess sheath 150 may be the same or similar to the articulatingmembers 18 of thearticulatable access sheath 10. As mentioned, the articulating members may have any shape, particularly a shape which allows interfitting or nesting as shown in FIG. 5. In addition, pullwires may be present which pass through the articulatingmembers 158 in a manner similar to thepullwire 80 illustrated in FIG. 5. However, the pullwires are not used to position the articulatingmembers 158. - The portion of the
sheath 150 having the articulatingmembers 158 is movable into an articulated position by action of theobturator 168 or other device which can fit within thecentral lumen 156. Once theobturator 168 has been placed within thecentral lumen 156 of thesheath 150, as shown, theobturator 168 can be moved into any configuration. For example, theobturator 168 can be shaped to have bends, arcs, curves or angles which in turn applies the same configuration to the surroundingsheath 150. Shaping of theobturator 168 can be achieved by any suitable mechanism, such as pullwires which extend through theobturator 158 and can be manipulated in a manner similar to thearticulatable access sheath 10. Thus, thesheath 150 andobturator 168 can be moved into articulated positions similar to those shown in FIGS. 2A-2D. - Actuation of the positioning mechanisms is achieved with the use of actuators, such as
actuators 170, 172, 174 located on anobturator handle 176. The obturator handle 176 may be connectable to ahandle 160 of thesheath 150 at a connection joint 178. Theactuators 170, 172, 173 are used to bend, arc or reshape theobturator 168 underlying the portion of thesheath 150 comprising articulatingmembers 158. For example, aprimary curve actuator 170 can be used to actuate one or more pull wires to form a primary curve in the portion of thesheath 150 comprising the series of articulatingmembers 158. Further, a secondary curve actuator 172 can be actuated to form a secondary curve in the portion of thesheath 150 comprising the series of actuatingmembers 158. And a theta actuator 174 can be manipulated to move thedistal tip 155 through an angle theta. - Once the
sheath 150 is in the desired configuration, a lockingactuator 180 on thehandle 160 may be used to actuate a locking mechanism to lock the articulatingmembers 158 in the articulated position. Optionally, theobturator 168 may also be locked in place by an obturator locking mechanism actuated by an obturator locking actuator 186. Typically, theobturator 168 would be locked in place prior to thesheath 150 to hold the sheath in the desired orientation. Once thesheath 150 is then locked, theobturator 168 may be unlocked and removed. Again, it may be appreciated thatsuch actuators handles handles sheath 150 and/orobturator 168. - FIGS.13A-13D illustrate a method of using the access system 148 for accessing the mitral valve MV. To gain access to the mitral valve, the access system 148 may be tracked from a puncture in the femoral vein, through the interior vena cava and into the right atrium. This may be facilitated by the use of a guidewire that is first inserted through the vasculature into the heart, and
sheath 150 andobturator 168 are then slidably introduced over the guidewire. Preferably,obturator 168 will have a guidewire lumen for this purpose as described above. As shown in FIG. 13A, the access system 148 is then punctured through a fossa F in the intra-atrialseptum S. Obturator 168 may further have a distal tip configured to penetrate the inter-atrial septum S, orobturator 168 may be removed and a separate penetration tool may be inserted though theaccess sheath 150. Alternatively, if a guidewire is used, the guidewire may have a tip suitable for penetrating the inter-atrial septum and the distal tip ofobturator 168 may be tapered to facilitate widening the guidewire penetration so as to allow passage ofsheath 150. The system 148 is then advanced through the fossa F so that thedistal tip 155 is directed over the mitral valve MV. Again, it may be appreciated that this approach serves merely as an example and other approaches may be used, such as through the jugular vein, femoral artery, port access or direct access, to name a few. It may also be appreciated that thesheath 150 andobturator 168 of the system 148 may alternatively be advanced in separate steps. - It is then desired to move and tip the
distal tip 155 so that thecentral lumen 156 is directed toward the target tissue, the mitral valve MV. In particular, thecentral lumen 156 is to be directed toward a specific area of the mitral valve MV, such as toward theopening 60 between the valve leaflets LF, so that a particular interventional procedure may be performed. Aprimary curve 200 may be formed due to actuation of theobturator 168, as described above. Theobturator 168 applies forces to thecentral lumen 156 to reposition the articulatingmembers 158. In this example, formation of theprimary curve 200 moves thedistal tip 155 within a primary plane, corresponding to previous plane X in FIG. 2A, parallel to the valve surface. This moves thedistal tip 155 laterally along the short axis of the mitral valve MV, and allows thedistal tip 155 to be centered over theopening 60. In this articulated position, any interventional devices which are passed through thecentral lumen 16 would be directed horizontally over the valve MV. To direct catheters or tools into theopening 60, it is necessary that thedistal tip 155 is pointed downward towards the mitral valve MV. - Referring to FIG. 13B, the
access sheath 150 is shown in an articulated position which includes asecondary curve 202 in a secondary plane, corresponding to previous plane Z in FIG. 2B. Formation of thesecondary curve 202 moves thedistal tip 15 vertically and angularly between the commissures C, directing thecentral lumen 156 toward the mitral valve MV. In this articulated position an interventional device which is passed through thecentral lumen 156 would be directed toward and/or through theopening 60. Although theprimary curve 200 and thesecondary curve 202 may be varied to accommodate different anatomical positions of the valve MV and different surgical procedures, further adjustment may be desired beyond these two curvatures for proper positioning of theaccess sheath 150. - Thus, the
access sheath 150 may include additional curvatures throughout the articulatingmembers 158 and/or allow thedistal tip 155 to move angularly through anangle theta 204 by action of theobturator 168. This moves thetip 155 vertically and angularly through a theta plane, corresponding to previous plane Y in FIGS. 2C-2D. Movement of thedistal tip 155 through theangle theta 50 in either direction is shown in dashed line in FIG. 13B. Consequently, thecentral lumen 156 can be directed toward the mitral valve MV within a plane which differs from the secondary plane. After such movements, theaccess sheath 150 will be in an articulated position which positions thedistal tip 15 so that the opening of thecentral lumen 156 at thetip 155 faces the desired direction. Once the desired articulated position is achieved, the articulatingmembers 158 are then locked in place by a locking feature, such as by activation of a locking mechanism. - Referring to FIG. 13C, the
obturator 168 is then removed while thesheath 150 remains in the articulated position. The lockedaccess sheath 150 allows for the passage ofinterventional devices 70, as illustrated in FIG. 13D. Theinterventional device 70 can be passed through thecentral lumen 156 toward the target tissue, in this case the mitral valve MV. Positioning of thedistal end 155 over theopening 60, as described above, allows thedevice 70 to pass through theopening 60 between the leaflets LF if desired, as shown. At this point, any desired surgical procedure may be applied to the mitral valve for correction of regurgitation or any other disorder. In a preferred method, the mitral valve is repaired using a “bow-tie” or “edge-to-edge” technique with devices introduced through the access sheath of the invention. Suitable devices and techniques are described in copending U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001400US), U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001500US), and U.S. patent application Ser. No. ______ (Attorney Docket No. 020489-001700US), filed on the same day as the present application, which have been incorporated herein by reference. Other procedures that may be performed using devices introduced through the access sheath of the invention include ablation of the pulmonary veins for treatment of atrial fibrillation, mapping and ablation of other regions in or on the heart, annuloplasty of the mitral valve, repair of other heart valves, repair of septal defects, and other diagnostic and therapeutic procedures in the heart. The access sheath of the invention is further suitable for accessing and performing procedures on other organs of the body either intraluminally or via surgical penetrations, including stomach, intestines, bowel, bladder, lungs, liver, gall bladder, uterus, and others. - It may be appreciated that in some embodiments both the
obturator 168 and thesheath 150 are independently steerable. In these embodiments, theobturator 168 andsheath 150 can be shaped or articulated by any suitable mechanism, such as pullwires which extend through theobturator 158 and separate pullwires which extend through thesheath 150 and can be manipulated to create bends, arcs, curves or angles. Thus, thesheath 150 andobturator 168 can be moved into articulated positions similar to those shown in FIGS. 2A-2D. - Referring now to FIG. 14,
kits 300 according to the present invention comprise any of the components described in relation to the present invention. In some embodiments, thekit 300 comprises an articulatable access sheath and instructions for use IFU. In other embodiments, thekit 300 comprises anaccess sheath 150, anarticulatable obturator 168 and instructions for use IFU. Optionally, any of the kits may further include any of the other system components described above, such as aninterventional device 70, or components associated with positioning a device in a body lumen, such as aguidewire 302 or needle 304. The instructions for use IFU will set forth any of the methods as described above, and all kit components will usually be packaged together in a pouch 305 or other conventional medical device packaging. Usually, those kit components which will be used in performing the procedure on the patient will be sterilized and maintained within the kit. Optionally, separate pouches, bags, trays or other packaging may be provided within a larger package, where the smaller packs may be opened separately to separately maintain the components in a sterile fashion. - Although the foregoing invention has been described in some detail by way of illustration and example, for purposes of clarity of understanding, it will be obvious that various alternatives, modifications and equivalents may be used and the above description should not be taken as limiting in scope of the invention which is defined by the appended claims.
Claims (84)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/441,753 US20040044350A1 (en) | 1999-04-09 | 2003-05-19 | Steerable access sheath and methods of use |
EP19171888.1A EP3539454B1 (en) | 2003-05-19 | 2004-05-18 | Articulatable access system |
EP04752714.8A EP1624792B1 (en) | 2003-05-19 | 2004-05-18 | Articulatable access sheath |
PCT/US2004/015741 WO2004103434A2 (en) | 2003-05-19 | 2004-05-18 | Articulatable access sheath and methods of use |
JP2006533226A JP2007511248A (en) | 2003-05-19 | 2004-05-18 | Articulating access sheath and method of use |
US12/392,670 US7682319B2 (en) | 1999-04-09 | 2009-02-25 | Steerable access sheath and methods of use |
US12/699,759 US8123703B2 (en) | 1999-04-09 | 2010-02-03 | Steerable access sheath and methods of use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12869099P | 1999-04-09 | 1999-04-09 | |
US09/544,930 US6629534B1 (en) | 1999-04-09 | 2000-04-07 | Methods and apparatus for cardiac valve repair |
US09/894,463 US6752813B2 (en) | 1999-04-09 | 2001-06-27 | Methods and devices for capturing and fixing leaflets in valve repair |
US10/441,753 US20040044350A1 (en) | 1999-04-09 | 2003-05-19 | Steerable access sheath and methods of use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/894,463 Continuation-In-Part US6752813B2 (en) | 1999-04-09 | 2001-06-27 | Methods and devices for capturing and fixing leaflets in valve repair |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/392,670 Division US7682319B2 (en) | 1999-04-09 | 2009-02-25 | Steerable access sheath and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040044350A1 true US20040044350A1 (en) | 2004-03-04 |
Family
ID=33476606
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/441,753 Abandoned US20040044350A1 (en) | 1999-04-09 | 2003-05-19 | Steerable access sheath and methods of use |
US12/392,670 Expired - Fee Related US7682319B2 (en) | 1999-04-09 | 2009-02-25 | Steerable access sheath and methods of use |
US12/699,759 Expired - Lifetime US8123703B2 (en) | 1999-04-09 | 2010-02-03 | Steerable access sheath and methods of use |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/392,670 Expired - Fee Related US7682319B2 (en) | 1999-04-09 | 2009-02-25 | Steerable access sheath and methods of use |
US12/699,759 Expired - Lifetime US8123703B2 (en) | 1999-04-09 | 2010-02-03 | Steerable access sheath and methods of use |
Country Status (4)
Country | Link |
---|---|
US (3) | US20040044350A1 (en) |
EP (2) | EP3539454B1 (en) |
JP (1) | JP2007511248A (en) |
WO (1) | WO2004103434A2 (en) |
Cited By (425)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030191479A1 (en) * | 2002-04-03 | 2003-10-09 | Thornton Sally C. | Body lumen closure |
US20030201519A1 (en) * | 1999-12-29 | 2003-10-30 | Lamson Michael A. | Semiconductor package with conductor impedance selected during assembly |
US20040002719A1 (en) * | 1997-06-27 | 2004-01-01 | Oz Mehmet C. | Method and apparatus for circulatory valve repair |
US20040030382A1 (en) * | 1999-04-09 | 2004-02-12 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20040059411A1 (en) * | 2000-10-26 | 2004-03-25 | Strecker Ernst Peter | Implantable valve system |
US20040127848A1 (en) * | 2002-12-30 | 2004-07-01 | Toby Freyman | Valve treatment catheter and methods |
US20040133274A1 (en) * | 2002-11-15 | 2004-07-08 | Webler William E. | Cord locking mechanism for use in small systems |
US20040215339A1 (en) * | 2002-10-24 | 2004-10-28 | Drasler William J. | Venous valve apparatus and method |
US20040230297A1 (en) * | 2002-04-03 | 2004-11-18 | Boston Scientific Corporation | Artificial valve |
WO2004103162A2 (en) | 1999-04-09 | 2004-12-02 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20050137681A1 (en) * | 2003-12-19 | 2005-06-23 | Scimed Life Systems, Inc. | Venous valve apparatus, system, and method |
US20050137676A1 (en) * | 2003-12-19 | 2005-06-23 | Scimed Life Systems, Inc. | Venous valve apparatus, system, and method |
US20050149096A1 (en) * | 2003-12-23 | 2005-07-07 | Hilal Said S. | Catheter with conduit traversing tip |
US20050149014A1 (en) * | 2001-11-15 | 2005-07-07 | Quantumcor, Inc. | Cardiac valve leaflet attachment device and methods thereof |
US20050251189A1 (en) * | 2004-05-07 | 2005-11-10 | Usgi Medical Inc. | Multi-position tissue manipulation assembly |
US20050267520A1 (en) * | 2004-05-12 | 2005-12-01 | Modesitt D B | Access and closure device and method |
WO2005112792A2 (en) | 2004-05-14 | 2005-12-01 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
US20060030885A1 (en) * | 2002-10-15 | 2006-02-09 | Hyde Gregory M | Apparatuses and methods for heart valve repair |
US20060036267A1 (en) * | 2004-08-11 | 2006-02-16 | Usgi Medical Inc. | Methods and apparatus for performing malabsorptive bypass procedures within a patient's gastro-intestinal lumen |
US20060047338A1 (en) * | 2004-09-02 | 2006-03-02 | Scimed Life Systems, Inc. | Cardiac valve, system, and method |
WO2006063199A2 (en) | 2004-12-09 | 2006-06-15 | The Foundry, Inc. | Aortic valve repair |
US20060173475A1 (en) * | 2005-02-01 | 2006-08-03 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
US20060178729A1 (en) * | 2005-02-07 | 2006-08-10 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US20060178550A1 (en) * | 2005-02-04 | 2006-08-10 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US20060229708A1 (en) * | 2005-02-07 | 2006-10-12 | Powell Ferolyn T | Methods, systems and devices for cardiac valve repair |
US20060271078A1 (en) * | 2005-05-12 | 2006-11-30 | Modesitt D B | Access and closure device and method |
US20070038293A1 (en) * | 1999-04-09 | 2007-02-15 | St Goar Frederick G | Device and methods for endoscopic annuloplasty |
US20070049908A1 (en) * | 2005-06-15 | 2007-03-01 | Jan Boese | Apparatus for automatic replacement of instruments during minimally invasive procedures |
US20070067021A1 (en) * | 2005-09-21 | 2007-03-22 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US20070112361A1 (en) * | 2005-11-07 | 2007-05-17 | Schonholz Steven M | Surgical repair systems and methods of using the same |
US20070167065A1 (en) * | 2006-01-13 | 2007-07-19 | Cook Incorporated | Wire guide having distal coupling tip |
US20070197858A1 (en) * | 2004-09-27 | 2007-08-23 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US20070208364A1 (en) * | 2006-03-02 | 2007-09-06 | Kms Development, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US20070213582A1 (en) * | 2006-03-09 | 2007-09-13 | Zollinger Christopher J | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US20070249905A1 (en) * | 2006-04-25 | 2007-10-25 | Nobis Rudolph H | Medical tubular assembly |
US20070249908A1 (en) * | 2006-04-24 | 2007-10-25 | Ifung Lu | Medical cannula and medical cannula system |
US20070250149A1 (en) * | 2006-04-21 | 2007-10-25 | Abbott Laboratories | Stiffening Support Catheters and Methods for Using the Same |
US20070250070A1 (en) * | 2006-04-24 | 2007-10-25 | Nobis Rudolph H | Medical instrument having a medical snare |
US20070250111A1 (en) * | 2006-04-25 | 2007-10-25 | Ifung Lu | Medical instrument having an articulatable end effector |
US20070250110A1 (en) * | 2006-04-24 | 2007-10-25 | Mattel, Inc. | Medical instrument handle and medical instrument having a handle |
US20070250012A1 (en) * | 2006-04-24 | 2007-10-25 | Ifung Lu | Medical instrument having a medical needle-knife |
WO2007124501A2 (en) * | 2006-04-21 | 2007-11-01 | Abbott Laboratories | Stiffening support catheter |
US20070260264A1 (en) * | 2006-05-04 | 2007-11-08 | Nobis Rudolph H | Medical instrument handle and medical instrument having same |
US20070270649A1 (en) * | 2006-05-18 | 2007-11-22 | Long Gary L | Medical instrument including a catheter having a catheter stiffener and method for using |
US20070270639A1 (en) * | 2006-05-17 | 2007-11-22 | Long Gary L | Medical instrument having a catheter and having a catheter accessory device and method for using |
US20070270895A1 (en) * | 2006-05-16 | 2007-11-22 | Nobis Rudolph H | Medical instrument having a needle knife |
US20070270648A1 (en) * | 2006-05-22 | 2007-11-22 | Kms Medical Llc | Torque-transmitting, variably flexible insertion device and method for transmitting torque and variably flexing an insertion device |
US20070282187A1 (en) * | 2006-05-11 | 2007-12-06 | Long Gary L | Medical instrument having a catheter and method for using a catheter |
US20070293821A1 (en) * | 2006-04-21 | 2007-12-20 | Abbott Laboratories | Systems, Methods, and Devices for Injecting Media Contrast |
US20070293846A1 (en) * | 2006-04-21 | 2007-12-20 | Abbott Laboratories | Dual Lumen Guidewire Support Catheter |
US20080004640A1 (en) * | 2006-06-28 | 2008-01-03 | Abbott Laboratories | Vessel closure device |
US20080017043A1 (en) * | 2006-06-01 | 2008-01-24 | The Coca-Cola Company | Tea Stick Brewing Package and Method |
US20080027281A1 (en) * | 2006-07-31 | 2008-01-31 | Chang Stanley F | Colonoscope guide and method of use for improved colonoscopy |
US20080039691A1 (en) * | 2006-08-10 | 2008-02-14 | Kms Development, Llc | Torque-transmitting, variably-flexible, corrugated insertion device and method for transmitting torque and variably flexing a corrugated insertion device |
US20080065014A1 (en) * | 2006-04-21 | 2008-03-13 | Abbott Laboratories | Systems, Methods, and Devices to Facilitate Wire and Device Crossings of Obstructions in Body Lumens |
US20080125861A1 (en) * | 2002-11-15 | 2008-05-29 | Webler William E | Valve aptation assist device |
US20080183194A1 (en) * | 1999-04-09 | 2008-07-31 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US20090005776A1 (en) * | 2007-06-25 | 2009-01-01 | Terumo Kabushiki Kaisha | Medical device |
US20090005643A1 (en) * | 2007-06-27 | 2009-01-01 | Syntheon Llc | Torque-transmitting, variably-flexible, locking insertion device and method for operating the insertion device |
DE102007040358A1 (en) | 2007-08-27 | 2009-03-05 | Technische Universität München | Trocar tube, trocar, obturator or rectoscope for transluminal endoscopic surgery over natural orifices |
US20090069809A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Pfo closing device |
US20090069810A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Biological tissue closing device |
US20090076525A1 (en) * | 2007-08-28 | 2009-03-19 | Terumo Kabushiki Kaisha | Pfo closing device |
US20090105729A1 (en) * | 2007-10-18 | 2009-04-23 | John Zentgraf | Minimally invasive repair of a valve leaflet in a beating heart |
US20090105744A1 (en) * | 2007-10-17 | 2009-04-23 | Modesitt D Bruce | Methods for forming tracts in tissue |
US20090131867A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system with cavity creation element |
US20090131950A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Vertebroplasty method with enhanced control |
US20090131886A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system |
US20090156995A1 (en) * | 1999-04-09 | 2009-06-18 | Evalve, Inc. | Steerable access sheath and methods of use |
US20090182427A1 (en) * | 2007-12-06 | 2009-07-16 | Osseon Therapeutics, Inc. | Vertebroplasty implant with enhanced interfacial shear strength |
US20090234443A1 (en) * | 2005-01-20 | 2009-09-17 | Ottma Ruediger | Catheter for the Transvascular Implantation of Prosthetic Heart Valves |
US20090281498A1 (en) * | 2006-04-19 | 2009-11-12 | Acosta Pablo G | Devices, system and methods for minimally invasive abdominal surgical procedures |
US20090281500A1 (en) * | 2006-04-19 | 2009-11-12 | Acosta Pablo G | Devices, system and methods for minimally invasive abdominal surgical procedures |
US20090299282A1 (en) * | 2007-11-16 | 2009-12-03 | Osseon Therapeutics, Inc. | Steerable vertebroplasty system with a plurality of cavity creation elements |
US20100016786A1 (en) * | 2008-07-21 | 2010-01-21 | Arstasis, Inc. | Devices, methods, and kits for forming tracts in tissue |
US20100016810A1 (en) * | 2008-07-21 | 2010-01-21 | Arstasis. Inc., | Devices and methods for forming tracts in tissue |
US20100022823A1 (en) * | 2005-09-27 | 2010-01-28 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US7670368B2 (en) | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7678133B2 (en) | 2004-07-10 | 2010-03-16 | Arstasis, Inc. | Biological tissue closure device and method |
US7682369B2 (en) | 1997-09-12 | 2010-03-23 | Evalve, Inc. | Surgical device for connecting soft tissue |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US20100174297A1 (en) * | 2005-01-21 | 2010-07-08 | Giovanni Speziali | Thorascopic Heart Valve Repair Method and Apparatus |
US20100179567A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100179571A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100228191A1 (en) * | 2009-03-05 | 2010-09-09 | Hansen Medical, Inc. | Lockable support assembly and method |
US7799038B2 (en) | 2006-01-20 | 2010-09-21 | Boston Scientific Scimed, Inc. | Translumenal apparatus, system, and method |
US7803130B2 (en) | 2006-01-09 | 2010-09-28 | Vance Products Inc. | Deflectable tip access sheath |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US20100305475A1 (en) * | 2007-04-23 | 2010-12-02 | Hinchliffe Peter W J | Guidewire with adjustable stiffness |
US7867274B2 (en) | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US20110022078A1 (en) * | 2009-07-23 | 2011-01-27 | Cameron Dale Hinman | Articulating mechanism |
US7892276B2 (en) | 2007-12-21 | 2011-02-22 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US20110054492A1 (en) * | 2009-08-26 | 2011-03-03 | Abbott Laboratories | Medical device for repairing a fistula |
US20110066233A1 (en) * | 2005-02-07 | 2011-03-17 | Thornton Troy L | Methods, systems and devices for cardiac valve repair |
WO2011034973A2 (en) | 2005-02-07 | 2011-03-24 | Abbott Vascular | Methods, systems and devices for cardiac valve repair |
US20110125178A1 (en) * | 2009-05-15 | 2011-05-26 | Michael Drews | Devices, methods and kits for forming tracts in tissue |
US7967853B2 (en) | 2007-02-05 | 2011-06-28 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
US7981152B1 (en) | 2004-12-10 | 2011-07-19 | Advanced Cardiovascular Systems, Inc. | Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites |
US7993303B2 (en) | 2006-04-21 | 2011-08-09 | Abbott Laboratories | Stiffening support catheter and methods for using the same |
US7998112B2 (en) | 2003-09-30 | 2011-08-16 | Abbott Cardiovascular Systems Inc. | Deflectable catheter assembly and method of making same |
US20110208215A1 (en) * | 2009-09-22 | 2011-08-25 | Modesitt D Bruce | Devices, methods, and kits for forming tracts in tissue |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US20110218568A1 (en) * | 2009-01-09 | 2011-09-08 | Voss Laveille K | Vessel closure devices, systems, and methods |
US20110224666A1 (en) * | 2003-01-21 | 2011-09-15 | Gareth Davies | Method of surgical perforation via the delivery of energy |
US20110238089A1 (en) * | 2007-12-17 | 2011-09-29 | Abbott Laboratories | Tissue closure system and methods of use |
US20110245812A1 (en) * | 2010-04-01 | 2011-10-06 | Martin Blocher | Medical instrument for microinvasive surgical interventions |
US20110282379A1 (en) * | 2009-01-16 | 2011-11-17 | Michael Lee | Intravascular Blood Filters and Methods of Use |
US8070804B2 (en) | 2002-11-15 | 2011-12-06 | Abbott Cardiovascular Systems Inc. | Apparatus and methods for heart valve repair |
US8133270B2 (en) | 2007-01-08 | 2012-03-13 | California Institute Of Technology | In-situ formation of a valve |
US8172839B2 (en) | 2006-02-24 | 2012-05-08 | Terumo Kabushiki Kaisha | PFO closing device |
US8187324B2 (en) | 2002-11-15 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Telescoping apparatus for delivering and adjusting a medical device in a vessel |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US8246574B2 (en) | 2006-04-21 | 2012-08-21 | Abbott Laboratories | Support catheter |
US20120245418A1 (en) * | 2005-08-30 | 2012-09-27 | Boston Scientific Scimed, Inc. | Method for forming an endoscope articulation joint |
WO2013022525A1 (en) * | 2011-08-08 | 2013-02-14 | Gyrus Ent, L.L.C. | Locking flexible surgical instruments |
US8398656B2 (en) | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8469995B2 (en) | 2002-06-04 | 2013-06-25 | Abbott Vascular Inc. | Blood vessel closure clip and delivery device |
US8486108B2 (en) | 2000-12-07 | 2013-07-16 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8518057B2 (en) | 2005-07-01 | 2013-08-27 | Abbott Laboratories | Clip applier and methods of use |
US20130225943A1 (en) * | 2012-02-22 | 2013-08-29 | Veran Medical Technologies, Inc. | Steerable surgical catheter having biopsy devices and related systems and methods for four dimensional soft tissue navigation |
EP2633821A2 (en) | 2009-09-15 | 2013-09-04 | Evalve, Inc. | Device for cardiac valve repair |
US8529587B2 (en) | 2003-01-30 | 2013-09-10 | Integrated Vascular Systems, Inc. | Methods of use of a clip applier |
US20130274714A1 (en) * | 2004-12-17 | 2013-10-17 | Biocardia, Inc. | Method Of Accessing A Renal Artery Of A Patient |
US8579932B2 (en) | 2002-02-21 | 2013-11-12 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US8585836B2 (en) | 2002-12-31 | 2013-11-19 | Integrated Vascular Systems, Inc. | Methods for manufacturing a clip and clip |
US8590760B2 (en) | 2004-05-25 | 2013-11-26 | Abbott Vascular Inc. | Surgical stapler |
US8597325B2 (en) | 2000-12-07 | 2013-12-03 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US8603116B2 (en) | 2010-08-04 | 2013-12-10 | Abbott Cardiovascular Systems, Inc. | Closure device with long tines |
US20140012085A1 (en) * | 2006-03-02 | 2014-01-09 | Syntheon, Llc | Variably Flexible Insertion Device and Method for Variably Flexing an Insertion Device |
US8657852B2 (en) | 2008-10-30 | 2014-02-25 | Abbott Vascular Inc. | Closure device |
US8690910B2 (en) | 2000-12-07 | 2014-04-08 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US20140114129A1 (en) * | 2007-05-08 | 2014-04-24 | Intuitive Surgical Operations, Inc. | Complex Shape Steerable Tissue Visualization and Manipulation Catheter |
US8728119B2 (en) | 2001-06-07 | 2014-05-20 | Abbott Vascular Inc. | Surgical staple |
US8758396B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US8758399B2 (en) | 2010-08-02 | 2014-06-24 | Abbott Cardiovascular Systems, Inc. | Expandable bioabsorbable plug apparatus and method |
US8758398B2 (en) | 2006-09-08 | 2014-06-24 | Integrated Vascular Systems, Inc. | Apparatus and method for delivering a closure element |
US8758400B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US8758231B2 (en) | 2009-05-14 | 2014-06-24 | Cook Medical Technologies Llc | Access sheath with active deflection |
US8784447B2 (en) | 2000-09-08 | 2014-07-22 | Abbott Vascular Inc. | Surgical stapler |
US8808310B2 (en) | 2006-04-20 | 2014-08-19 | Integrated Vascular Systems, Inc. | Resettable clip applier and reset tools |
US20140243877A9 (en) * | 2009-01-16 | 2014-08-28 | Claret Medical, Inc. | Intravascular blood filters and methods of use |
US8821534B2 (en) | 2010-12-06 | 2014-09-02 | Integrated Vascular Systems, Inc. | Clip applier having improved hemostasis and methods of use |
US8820602B2 (en) | 2007-12-18 | 2014-09-02 | Abbott Laboratories | Modular clip applier |
US8828079B2 (en) | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
US8858594B2 (en) | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
US8876796B2 (en) | 2010-12-30 | 2014-11-04 | Claret Medical, Inc. | Method of accessing the left common carotid artery |
US8893947B2 (en) | 2007-12-17 | 2014-11-25 | Abbott Laboratories | Clip applier and methods of use |
US8905937B2 (en) | 2009-02-26 | 2014-12-09 | Integrated Vascular Systems, Inc. | Methods and apparatus for locating a surface of a body lumen |
US20140371764A1 (en) * | 2011-09-13 | 2014-12-18 | Medrobotics Corporation | Highly articulated probes with anti-twist link arrangement, methods of formation thereof, and methods of performing medical procedures |
US20150005704A1 (en) * | 2013-05-07 | 2015-01-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Steerable Medical Device Having Multiple Curve Profiles |
US8926656B2 (en) | 2003-01-30 | 2015-01-06 | Integated Vascular Systems, Inc. | Clip applier and methods of use |
US8926633B2 (en) | 2005-06-24 | 2015-01-06 | Abbott Laboratories | Apparatus and method for delivering a closure element |
US8956388B2 (en) | 2000-01-05 | 2015-02-17 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant |
US8974489B2 (en) | 2009-07-27 | 2015-03-10 | Claret Medical, Inc. | Dual endovascular filter and methods of use |
US20150105721A1 (en) * | 2013-10-10 | 2015-04-16 | Oscor Inc. | Steerable medical devices |
US9034032B2 (en) | 2011-10-19 | 2015-05-19 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9044221B2 (en) | 2010-12-29 | 2015-06-02 | Neochord, Inc. | Exchangeable system for minimally invasive beating heart repair of heart valve leaflets |
US9089674B2 (en) | 2000-10-06 | 2015-07-28 | Integrated Vascular Systems, Inc. | Apparatus and methods for positioning a vascular sheath |
US9089311B2 (en) | 2009-01-09 | 2015-07-28 | Abbott Vascular Inc. | Vessel closure devices and methods |
US9125740B2 (en) | 2011-06-21 | 2015-09-08 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US9149276B2 (en) | 2011-03-21 | 2015-10-06 | Abbott Cardiovascular Systems, Inc. | Clip and deployment apparatus for tissue closure |
US9149602B2 (en) | 2005-04-22 | 2015-10-06 | Advanced Cardiovascular Systems, Inc. | Dual needle delivery system |
US20150374211A1 (en) * | 2006-03-02 | 2015-12-31 | Syntheon, Llc | Variably Flexible Insertion Device and Method for Variably Flexing an Insertion Device |
US20160051331A1 (en) * | 2010-11-15 | 2016-02-25 | Intuitive Surgical Operations, Inc. | Actuation Cable Having Multiple Friction Characteristics |
US9282965B2 (en) | 2008-05-16 | 2016-03-15 | Abbott Laboratories | Apparatus and methods for engaging tissue |
US9314230B2 (en) | 2009-01-09 | 2016-04-19 | Abbott Vascular Inc. | Closure device with rapidly eroding anchor |
US9332893B2 (en) | 2005-02-02 | 2016-05-10 | Intuitive Surgical Operations, Inc. | Delivery of biological compounds to ischemic and/or infarcted tissue |
US9332976B2 (en) | 2011-11-30 | 2016-05-10 | Abbott Cardiovascular Systems, Inc. | Tissue closure device |
US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
US9364326B2 (en) | 2011-06-29 | 2016-06-14 | Mitralix Ltd. | Heart valve repair devices and methods |
US9414824B2 (en) | 2009-01-16 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9414820B2 (en) | 2009-01-09 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9421098B2 (en) | 2010-12-23 | 2016-08-23 | Twelve, Inc. | System for mitral valve repair and replacement |
US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
WO2016183300A2 (en) | 2015-05-12 | 2016-11-17 | Rhythm Xience, Inc. | Catheter system for left heart access |
US20160338729A1 (en) * | 2015-05-19 | 2016-11-24 | Jim Hassett | Catheter system for left heart access |
US9510885B2 (en) | 2007-11-16 | 2016-12-06 | Osseon Llc | Steerable and curvable cavity creation system |
US9510732B2 (en) | 2005-10-25 | 2016-12-06 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US9526401B2 (en) | 2005-02-02 | 2016-12-27 | Intuitive Surgical Operations, Inc. | Flow reduction hood systems |
US20170020567A1 (en) * | 2015-05-19 | 2017-01-26 | Rhythm Xience, Inc. | Catheter System for Left Heart Access |
US9566144B2 (en) | 2015-04-22 | 2017-02-14 | Claret Medical, Inc. | Vascular filters, deflectors, and methods |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US9579091B2 (en) | 2000-01-05 | 2017-02-28 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US20170071688A1 (en) * | 2014-09-04 | 2017-03-16 | Memic Innovative Surgery Ltd. | Device and system including mechanical arms |
US20170086900A1 (en) * | 2015-09-24 | 2017-03-30 | Medidata Sp. Z O.O. | Cryoapplicator for minimally invasive surgical cardiac ablation |
US9622859B2 (en) | 2005-02-01 | 2017-04-18 | Boston Scientific Scimed, Inc. | Filter system and method |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9668859B2 (en) | 2011-08-05 | 2017-06-06 | California Institute Of Technology | Percutaneous heart valve delivery systems |
US9700412B2 (en) | 2014-06-26 | 2017-07-11 | Mitralix Ltd. | Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices |
US9744037B2 (en) | 2013-03-15 | 2017-08-29 | California Institute Of Technology | Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves |
US9763658B2 (en) | 2002-08-02 | 2017-09-19 | Cedars-Sinai Medical Center | Methods and apparatus for atrioventricular valve repair |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
WO2017180419A1 (en) * | 2016-04-14 | 2017-10-19 | Baylor College Of Medicine | Sheaths, methods of use, and kits including the same |
US9901443B2 (en) | 2011-10-19 | 2018-02-27 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10004388B2 (en) | 2006-09-01 | 2018-06-26 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
US10064540B2 (en) | 2005-02-02 | 2018-09-04 | Intuitive Surgical Operations, Inc. | Visualization apparatus for transseptal access |
US10070772B2 (en) | 2006-09-01 | 2018-09-11 | Intuitive Surgical Operations, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
US10076415B1 (en) | 2018-01-09 | 2018-09-18 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10080657B2 (en) | 2013-03-07 | 2018-09-25 | Cedars-Sinai Medical Center | Catheter based apical approach heart prostheses delivery system |
US10105222B1 (en) | 2018-01-09 | 2018-10-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10105221B2 (en) | 2013-03-07 | 2018-10-23 | Cedars-Sinai Medical Center | Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis |
US10111751B1 (en) | 2018-01-09 | 2018-10-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10111747B2 (en) | 2013-05-20 | 2018-10-30 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
WO2018202720A1 (en) * | 2017-05-05 | 2018-11-08 | Flexicare (Group) Limited | Intubation devices |
US10123873B1 (en) | 2018-01-09 | 2018-11-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10130475B1 (en) | 2018-01-09 | 2018-11-20 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US20180333042A1 (en) * | 2017-05-18 | 2018-11-22 | Loubert S. Suddaby | Self-anchoring endoscopy sheath |
US10136993B1 (en) | 2018-01-09 | 2018-11-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US20180344981A1 (en) * | 2017-02-07 | 2018-12-06 | Qmax, Llc | Deflectable catheter with compound curve articulation and materials for the same |
US10159527B2 (en) | 2004-09-24 | 2018-12-25 | Syntheon, Llc | Selective stiffening catheter and methods for operating a selective stiffening catheter |
US10159570B1 (en) | 2018-01-09 | 2018-12-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10188392B2 (en) | 2014-12-19 | 2019-01-29 | Abbott Cardiovascular Systems, Inc. | Grasping for tissue repair |
US10231837B1 (en) | 2018-01-09 | 2019-03-19 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10238493B1 (en) | 2018-01-09 | 2019-03-26 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10238494B2 (en) | 2015-06-29 | 2019-03-26 | Evalve, Inc. | Self-aligning radiopaque ring |
US10238495B2 (en) | 2015-10-09 | 2019-03-26 | Evalve, Inc. | Delivery catheter handle and methods of use |
US10238490B2 (en) | 2015-08-21 | 2019-03-26 | Twelve, Inc. | Implant heart valve devices, mitral valve repair devices and associated systems and methods |
US10245144B1 (en) | 2018-01-09 | 2019-04-02 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10265172B2 (en) | 2016-04-29 | 2019-04-23 | Medtronic Vascular, Inc. | Prosthetic heart valve devices with tethered anchors and associated systems and methods |
US10278588B2 (en) | 2005-02-02 | 2019-05-07 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US20190150908A1 (en) * | 2012-06-29 | 2019-05-23 | Neotract, Inc. | Flexible system for delivering an anchor |
US10314586B2 (en) | 2016-12-13 | 2019-06-11 | Evalve, Inc. | Rotatable device and method for fixing tricuspid valve tissue |
US10363138B2 (en) | 2016-11-09 | 2019-07-30 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10363134B2 (en) | 2005-10-28 | 2019-07-30 | Jenavalve Technology, Inc. | Device for the implantation and fixation of prosthetic valves |
US10376673B2 (en) | 2015-06-19 | 2019-08-13 | Evalve, Inc. | Catheter guiding system and methods |
US10390943B2 (en) | 2014-03-17 | 2019-08-27 | Evalve, Inc. | Double orifice device for transcatheter mitral valve replacement |
US10390685B2 (en) | 2006-12-21 | 2019-08-27 | Intuitive Surgical Operations, Inc. | Off-axis visualization systems |
US10398553B2 (en) | 2016-11-11 | 2019-09-03 | Evalve, Inc. | Opposing disk device for grasping cardiac valve tissue |
US10398552B2 (en) | 2016-11-15 | 2019-09-03 | Abbott Cardiovascular Systems Inc. | Fixation devices, systems and methods for heart valve leaf repair |
US10413408B2 (en) | 2015-08-06 | 2019-09-17 | Evalve, Inc. | Delivery catheter systems, methods, and devices |
US10426616B2 (en) | 2016-11-17 | 2019-10-01 | Evalve, Inc. | Cardiac implant delivery system |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10441753B2 (en) | 2012-05-25 | 2019-10-15 | Arstasis, Inc. | Vascular access configuration |
US10463380B2 (en) | 2016-12-09 | 2019-11-05 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
US10470643B2 (en) | 2006-06-14 | 2019-11-12 | Intuitive Surgical Operations, Inc. | In-vivo visualization systems |
US10478241B2 (en) | 2016-10-27 | 2019-11-19 | Merit Medical Systems, Inc. | Articulating osteotome with cement delivery channel |
US20190374746A1 (en) * | 2017-03-30 | 2019-12-12 | University Of Hawaii | Steerable surgical devices with shape memory alloy wires |
US10507109B2 (en) | 2018-01-09 | 2019-12-17 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10507108B2 (en) | 2017-04-18 | 2019-12-17 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10517726B2 (en) | 2015-05-14 | 2019-12-31 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10524912B2 (en) | 2015-04-02 | 2020-01-07 | Abbott Cardiovascular Systems, Inc. | Tissue fixation devices and methods |
US10524792B2 (en) | 2014-12-04 | 2020-01-07 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
US20200022754A1 (en) * | 2017-03-24 | 2020-01-23 | Robert J. Cottone | Systems and methods for tissue displacement |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US10588620B2 (en) | 2018-03-23 | 2020-03-17 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
WO2020072895A1 (en) * | 2018-10-04 | 2020-04-09 | The University Of Chicago | Lima crossover integrated catheter system |
US10617481B2 (en) | 2016-03-09 | 2020-04-14 | Memic Innovative Surgey Ltd. | Modular device comprising mechanical arms |
US10624762B2 (en) | 2018-09-07 | 2020-04-21 | Orthorebirth Usa | Bone graft delivery device for minimally invasive surgery |
US10624652B2 (en) | 2010-04-29 | 2020-04-21 | Dfine, Inc. | System for use in treatment of vertebral fractures |
US20200121894A1 (en) * | 2017-07-27 | 2020-04-23 | Evalve, Inc. | Intravascular delivery system with centralized steering |
US10631871B2 (en) | 2003-05-19 | 2020-04-28 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US10646342B1 (en) | 2017-05-10 | 2020-05-12 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10660656B2 (en) | 2017-01-06 | 2020-05-26 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
US10660625B2 (en) | 2014-11-04 | 2020-05-26 | Abbott Cardiovascular Systems, Inc. | One-way actuator knob |
US10667804B2 (en) | 2014-03-17 | 2020-06-02 | Evalve, Inc. | Mitral valve fixation device removal devices and methods |
US10667912B2 (en) | 2017-04-18 | 2020-06-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10667815B2 (en) | 2015-07-21 | 2020-06-02 | Evalve, Inc. | Tissue grasping devices and related methods |
US10675447B2 (en) | 2012-05-25 | 2020-06-09 | Arstasis, Inc. | Vascular access configuration |
US10695178B2 (en) | 2011-06-01 | 2020-06-30 | Neochord, Inc. | Minimally invasive repair of heart valve leaflets |
US10702380B2 (en) | 2011-10-19 | 2020-07-07 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10736632B2 (en) | 2016-07-06 | 2020-08-11 | Evalve, Inc. | Methods and devices for valve clip excision |
US10743876B2 (en) | 2011-09-13 | 2020-08-18 | Abbott Cardiovascular Systems Inc. | System for fixation of leaflets of a heart valve |
US10743977B2 (en) | 2009-01-16 | 2020-08-18 | Boston Scientific Scimed, Inc. | Intravascular blood filter |
US10751507B2 (en) | 2017-04-10 | 2020-08-25 | Syn Variflex, Llc | Thermally controlled variable-flexibility catheters and methods of manufacturing same |
US20200268238A1 (en) * | 2018-12-21 | 2020-08-27 | Ambu A/S | Articulated tip part for an endoscope |
US10758265B2 (en) | 2014-11-14 | 2020-09-01 | Cedars-Sinai Medical Center | Cardiovascular access and device delivery system |
US10765517B2 (en) | 2015-10-01 | 2020-09-08 | Neochord, Inc. | Ringless web for repair of heart valves |
US10779837B2 (en) | 2016-12-08 | 2020-09-22 | Evalve, Inc. | Adjustable arm device for grasping tissues |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US10799359B2 (en) | 2014-09-10 | 2020-10-13 | Cedars-Sinai Medical Center | Method and apparatus for percutaneous delivery and deployment of a cardiac valve prosthesis |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799312B2 (en) | 2017-04-28 | 2020-10-13 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US10799675B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Cam controlled multi-direction steerable handles |
US10806575B2 (en) | 2008-08-22 | 2020-10-20 | Edwards Lifesciences Corporation | Heart valve treatment system |
US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US10835714B2 (en) | 2016-03-21 | 2020-11-17 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10856986B2 (en) | 2008-12-22 | 2020-12-08 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
US10856987B2 (en) | 2009-05-07 | 2020-12-08 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
US10893939B2 (en) | 2012-10-23 | 2021-01-19 | Valtech Cardio, Ltd. | Controlled steering functionality for implant delivery tool |
US10905554B2 (en) | 2017-01-05 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve coaptation device |
US10912644B2 (en) | 2018-10-05 | 2021-02-09 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US10912637B2 (en) | 2013-03-14 | 2021-02-09 | Neotract, Inc. | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
US10945844B2 (en) | 2018-10-10 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10945719B2 (en) | 2005-05-20 | 2021-03-16 | Neotract, Inc. | Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures |
US10959845B2 (en) | 2016-07-08 | 2021-03-30 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
US10966709B2 (en) | 2018-09-07 | 2021-04-06 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
US10973592B2 (en) | 2017-03-09 | 2021-04-13 | Memie Innovative Surgery Ltd. | Control console for surgical device with mechanical arms |
US10973639B2 (en) | 2018-01-09 | 2021-04-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973638B2 (en) | 2016-07-07 | 2021-04-13 | Edwards Lifesciences Corporation | Device and method for treating vascular insufficiency |
US10973637B2 (en) | 2013-12-26 | 2021-04-13 | Valtech Cardio, Ltd. | Implantation of flexible implant |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US20210128889A1 (en) * | 2018-07-20 | 2021-05-06 | Olympus Corporation | Guide wire holder |
US20210145510A1 (en) * | 2019-11-18 | 2021-05-20 | Nido Surgical Inc. | Instrument port for epicardial ablation with inflatable balloon |
US11020227B2 (en) | 2015-04-30 | 2021-06-01 | Valtech Cardio, Ltd. | Annuloplasty technologies |
US11026744B2 (en) | 2016-11-28 | 2021-06-08 | Dfine, Inc. | Tumor ablation devices and related methods |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11040174B2 (en) | 2017-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US11051940B2 (en) | 2017-09-07 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic spacer device for heart valve |
US11065001B2 (en) | 2013-10-23 | 2021-07-20 | Valtech Cardio, Ltd. | Anchor magazine |
US11065119B2 (en) | 2017-05-12 | 2021-07-20 | Evalve, Inc. | Long arm valve repair clip |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11071628B2 (en) | 2014-10-14 | 2021-07-27 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
US11071564B2 (en) | 2016-10-05 | 2021-07-27 | Evalve, Inc. | Cardiac valve cutting device |
US11076958B2 (en) | 2009-05-04 | 2021-08-03 | Valtech Cardio, Ltd. | Annuloplasty ring delivery catheters |
US11083580B2 (en) | 2016-12-30 | 2021-08-10 | Pipeline Medical Technologies, Inc. | Method of securing a leaflet anchor to a mitral valve leaflet |
US11090036B2 (en) | 2005-05-20 | 2021-08-17 | Neotract, Inc. | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US11116484B2 (en) * | 2018-10-31 | 2021-09-14 | Hongming Zhu | Lens assembly for 3D electronic nasopharyngoscope |
US11116634B2 (en) | 2008-12-22 | 2021-09-14 | Valtech Cardio Ltd. | Annuloplasty implants |
US11123191B2 (en) | 2018-07-12 | 2021-09-21 | Valtech Cardio Ltd. | Annuloplasty systems and locking tools therefor |
US11122971B2 (en) | 2016-08-18 | 2021-09-21 | Neptune Medical Inc. | Device and method for enhanced visualization of the small intestine |
US11135398B2 (en) | 2018-07-19 | 2021-10-05 | Neptune Medical Inc. | Dynamically rigidizing composite medical structures |
US11135421B2 (en) * | 2019-02-07 | 2021-10-05 | Synecor Llc | Conduit for transseptal passage of devices to the aorta |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
US11141158B2 (en) | 2011-09-13 | 2021-10-12 | Abbott Cardiovascular Systems Inc. | Independent gripper |
US11141271B2 (en) | 2009-10-29 | 2021-10-12 | Valtech Cardio Ltd. | Tissue anchor for annuloplasty device |
US11154390B2 (en) | 2017-12-19 | 2021-10-26 | Claret Medical, Inc. | Systems for protection of the cerebral vasculature during a cardiac procedure |
US11173030B2 (en) | 2018-05-09 | 2021-11-16 | Neochord, Inc. | Suture length adjustment for minimally invasive heart valve repair |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11185412B2 (en) | 2009-05-04 | 2021-11-30 | Valtech Cardio Ltd. | Deployment techniques for annuloplasty implants |
US11191630B2 (en) | 2017-10-27 | 2021-12-07 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US11197759B2 (en) | 2011-11-04 | 2021-12-14 | Valtech Cardio Ltd. | Implant having multiple adjusting mechanisms |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US11197681B2 (en) | 2009-05-20 | 2021-12-14 | Merit Medical Systems, Inc. | Steerable curvable vertebroplasty drill |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11202709B2 (en) | 2009-02-17 | 2021-12-21 | Valtech Cardio Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US11207181B2 (en) | 2018-04-18 | 2021-12-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11219351B2 (en) | 2015-09-03 | 2022-01-11 | Neptune Medical Inc. | Device for endoscopic advancement through the small intestine |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11241308B2 (en) | 2015-07-23 | 2022-02-08 | Cedars-Sinai Medical Center | Device for securing heart valve leaflets |
US11246705B2 (en) * | 2016-02-10 | 2022-02-15 | Abbott Cardiovascular Systems Inc. | System and method for implant delivery |
US11253360B2 (en) | 2018-05-09 | 2022-02-22 | Neochord, Inc. | Low profile tissue anchor for minimally invasive heart valve repair |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11291544B2 (en) | 2018-02-02 | 2022-04-05 | Cedars-Sinai Medical Center | Delivery platforms, devices, and methods for tricuspid valve repair |
US11291354B2 (en) * | 2016-12-22 | 2022-04-05 | Olympus Corporation | Flexible tube insertion apparatus and flexible tube insertion method |
US20220142778A1 (en) * | 2019-01-28 | 2022-05-12 | Vesalius Cardiovascular Inc. | Apparatus for use in repairing mitral valves and method of use thereof |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11337790B2 (en) | 2017-02-22 | 2022-05-24 | Boston Scientific Scimed, Inc. | Systems and methods for protecting the cerebral vasculature |
US11344310B2 (en) | 2012-10-23 | 2022-05-31 | Valtech Cardio Ltd. | Percutaneous tissue anchor techniques |
US11344414B2 (en) | 2006-12-05 | 2022-05-31 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11351023B2 (en) | 2018-08-21 | 2022-06-07 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11357500B2 (en) * | 2018-09-12 | 2022-06-14 | Lsi Solutions, Inc. | Surgical suturing device for repair of tricuspid regurgitation and methods thereof |
US11376126B2 (en) | 2019-04-16 | 2022-07-05 | Neochord, Inc. | Transverse helical cardiac anchor for minimally invasive heart valve repair |
US11389297B2 (en) | 2018-04-12 | 2022-07-19 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
US11406250B2 (en) | 2005-02-02 | 2022-08-09 | Intuitive Surgical Operations, Inc. | Methods and apparatus for treatment of atrial fibrillation |
US11439491B2 (en) | 2018-04-26 | 2022-09-13 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US11439501B2 (en) | 2017-01-25 | 2022-09-13 | Cedars-Sinai Medical Center | Device for securing heart valve leaflets |
US11464636B2 (en) | 2019-10-11 | 2022-10-11 | Evalve, Inc. | Repair clip for variable tissue thickness |
US11471282B2 (en) | 2019-03-19 | 2022-10-18 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US11478152B2 (en) | 2005-02-02 | 2022-10-25 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US11497605B2 (en) | 2005-03-17 | 2022-11-15 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US11504149B2 (en) | 2005-05-20 | 2022-11-22 | Teleflex Life Sciences Limited | Median lobe destruction apparatus and method |
US11510723B2 (en) | 2018-11-08 | 2022-11-29 | Dfine, Inc. | Tumor ablation device and related systems and methods |
US11517718B2 (en) | 2016-11-07 | 2022-12-06 | Edwards Lifesciences Corporation | Apparatus for the introduction and manipulation of multiple telescoping catheters |
US11534583B2 (en) | 2013-03-14 | 2022-12-27 | Valtech Cardio Ltd. | Guidewire feeder |
US11534303B2 (en) | 2020-04-09 | 2022-12-27 | Evalve, Inc. | Devices and systems for accessing and repairing a heart valve |
US11540835B2 (en) | 2016-05-26 | 2023-01-03 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US11547286B2 (en) * | 2020-01-22 | 2023-01-10 | Brio13Inv. LLC | Stylet assembly |
US11547564B2 (en) | 2018-01-09 | 2023-01-10 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11583400B2 (en) | 2012-12-06 | 2023-02-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guided advancement of a tool |
US11583396B2 (en) | 2009-12-04 | 2023-02-21 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US11589989B2 (en) | 2017-03-31 | 2023-02-28 | Neochord, Inc. | Minimally invasive heart valve repair in a beating heart |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US11602434B2 (en) | 2009-12-02 | 2023-03-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Systems and methods for tissue adjustment |
US11607301B2 (en) | 2009-01-16 | 2023-03-21 | Boston Scientific Scimed, Inc. | Intravascular blood filters and methods of use |
US11617652B2 (en) | 2009-10-29 | 2023-04-04 | Edwards Lifesciences Innovation (Israel) Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US11622859B2 (en) | 2019-11-08 | 2023-04-11 | Evalve, Inc. | Medical device delivery system with locking system |
US11660137B2 (en) | 2006-09-29 | 2023-05-30 | Boston Scientific Medical Device Limited | Connector system for electrosurgical device |
US11660189B2 (en) | 2019-07-15 | 2023-05-30 | Evalve, Inc. | Wide clip with nondeformable wings |
US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US11666442B2 (en) | 2018-01-26 | 2023-06-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
US11672520B2 (en) | 2017-12-23 | 2023-06-13 | Teleflex Life Sciences Limited | Expandable tissue engagement apparatus and method |
US11684475B2 (en) | 2016-12-30 | 2023-06-27 | Pipeline Medical Technologies, Inc. | Method and apparatus for transvascular implantation of neo chordae tendinae |
US11684447B2 (en) | 2012-05-31 | 2023-06-27 | Boston Scientific Medical Device Limited | Radiofrequency perforation apparatus |
US11696828B2 (en) | 2016-12-30 | 2023-07-11 | Pipeline Medical Technologies, Inc. | Method and apparatus for mitral valve chord repair |
US11701229B2 (en) | 2019-11-14 | 2023-07-18 | Evalve, Inc. | Kit with coaptation aid and fixation system and methods for valve repair |
US11707228B2 (en) | 2019-09-26 | 2023-07-25 | Evalve, Inc. | Systems and methods for intra-procedural cardiac pressure monitoring |
US20230248956A1 (en) * | 2022-02-10 | 2023-08-10 | St. Jude Medical, Cardiology Division, Inc. | Integrated Hemostasis Bypass Valve |
US11724070B2 (en) | 2019-12-19 | 2023-08-15 | Boston Scientific Medical Device Limited | Methods for determining a position of a first medical device with respect to a second medical device, and related systems and medical devices |
US11723728B2 (en) | 2015-09-04 | 2023-08-15 | Momentis Surgical Ltd. | Actuation of a device comprising mechanical arms |
US11744443B2 (en) | 2020-03-30 | 2023-09-05 | Neptune Medical Inc. | Layered walls for rigidizing devices |
US11744638B2 (en) | 2006-09-29 | 2023-09-05 | Boston Scientific Medical Device Limited | Electrosurgical device |
US11759190B2 (en) | 2019-10-18 | 2023-09-19 | Boston Scientific Medical Device Limited | Lock for medical devices, and related systems and methods |
US11766327B2 (en) | 2009-05-04 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Implantation of repair chords in the heart |
US11766290B2 (en) | 2015-09-09 | 2023-09-26 | Boston Scientific Medical Device Limited | Epicardial access system and methods |
US11779410B2 (en) | 2017-03-09 | 2023-10-10 | Momentis Surgical Ltd | Control console including an input arm for control of a surgical mechanical arm |
US11779463B2 (en) | 2018-01-24 | 2023-10-10 | Edwards Lifesciences Innovation (Israel) Ltd. | Contraction of an annuloplasty structure |
US11793446B2 (en) | 2020-06-17 | 2023-10-24 | Boston Scientific Medical Device Limited | Electroanatomical mapping system with visualization of energy-delivery and elongated needle assemblies |
US11793392B2 (en) | 2019-04-17 | 2023-10-24 | Neptune Medical Inc. | External working channels |
US11801087B2 (en) | 2019-11-13 | 2023-10-31 | Boston Scientific Medical Device Limited | Apparatus and methods for puncturing tissue |
US11801140B2 (en) | 2019-11-14 | 2023-10-31 | Evalve, Inc. | Catheter assembly with coaptation aid and methods for valve repair |
US11819411B2 (en) | 2019-10-29 | 2023-11-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
US11819243B2 (en) | 2020-03-19 | 2023-11-21 | Boston Scientific Medical Device Limited | Medical sheath and related systems and methods |
US11826075B2 (en) | 2020-04-07 | 2023-11-28 | Boston Scientific Medical Device Limited | Elongated medical assembly |
US11832784B2 (en) | 2017-11-02 | 2023-12-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant-cinching devices and systems |
US11833034B2 (en) | 2016-01-13 | 2023-12-05 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US11839544B2 (en) | 2019-02-14 | 2023-12-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11850151B2 (en) | 2019-07-15 | 2023-12-26 | Evalve, Inc. | Proximal element actuator fixation and release mechanisms |
US11857415B2 (en) | 2011-11-08 | 2024-01-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
US11878131B2 (en) | 2017-12-05 | 2024-01-23 | Boston Scientific Medical Device Limited | Transseptal guide wire puncture system |
US11890194B2 (en) | 2013-03-15 | 2024-02-06 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
US11931098B2 (en) | 2020-02-19 | 2024-03-19 | Boston Scientific Medical Device Limited | System and method for carrying out a medical procedure |
US11931262B2 (en) | 2016-12-30 | 2024-03-19 | Pipeline Medical Technologies, Inc. | Method and apparatus for transvascular implantation of neo chordae tendinae |
US11937778B2 (en) | 2022-04-27 | 2024-03-26 | Neptune Medical Inc. | Apparatuses and methods for determining if an endoscope is contaminated |
US11938285B2 (en) | 2020-06-17 | 2024-03-26 | Boston Scientific Medical Device Limited | Stop-movement device for elongated medical assembly |
US11937796B2 (en) | 2020-06-18 | 2024-03-26 | Boston Scientific Medical Device Limited | Tissue-spreader assembly |
US11937873B2 (en) | 2013-03-12 | 2024-03-26 | Boston Scientific Medical Device Limited | Electrosurgical device having a lumen |
US11963712B2 (en) | 2016-06-20 | 2024-04-23 | Evalve, Inc. | Transapical removal device |
US11969226B2 (en) | 2019-11-04 | 2024-04-30 | Momentis Surgical Ltd | Modular device comprising mechanical arms |
Families Citing this family (165)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6702811B2 (en) | 1999-04-05 | 2004-03-09 | Medtronic, Inc. | Ablation catheter assembly with radially decreasing helix and method of use |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US8774913B2 (en) * | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US7857369B2 (en) * | 2004-06-30 | 2010-12-28 | Case Western Reserve University | Biologically inspired gripping device |
US7988735B2 (en) * | 2005-06-15 | 2011-08-02 | Matthew Yurek | Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement |
US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
US8926695B2 (en) | 2006-12-05 | 2015-01-06 | Valtech Cardio, Ltd. | Segmented ring placement |
WO2008106549A1 (en) | 2007-02-27 | 2008-09-04 | Carnegie Mellon University | A system for controlling the movement of a multilinked device |
US9533122B2 (en) * | 2007-05-18 | 2017-01-03 | Boston Scientific Scimed, Inc. | Catheter drive system with control handle rotatable about two axes separated from housing by shaft |
US8864675B2 (en) * | 2007-06-28 | 2014-10-21 | W. L. Gore & Associates, Inc. | Catheter |
US8852112B2 (en) * | 2007-06-28 | 2014-10-07 | W. L. Gore & Associates, Inc. | Catheter with deflectable imaging device and bendable electrical conductor |
US9211077B2 (en) * | 2007-12-13 | 2015-12-15 | The Invention Science Fund I, Llc | Methods and systems for specifying an avatar |
EP2276392A4 (en) | 2008-04-14 | 2013-03-27 | Univ Carnegie Mellon | Articulated device with visualization system |
US9125562B2 (en) | 2009-07-01 | 2015-09-08 | Avinger, Inc. | Catheter-based off-axis optical coherence tomography imaging system |
US8062316B2 (en) | 2008-04-23 | 2011-11-22 | Avinger, Inc. | Catheter system and method for boring through blocked vascular passages |
US9192472B2 (en) | 2008-06-16 | 2015-11-24 | Valtec Cardio, Ltd. | Annuloplasty devices and methods of delivery therefor |
US9101735B2 (en) * | 2008-07-07 | 2015-08-11 | Intuitive Surgical Operations, Inc. | Catheter control systems |
JP2010017483A (en) * | 2008-07-14 | 2010-01-28 | Olympus Corp | Endoscope bending tube and endoscope with bending tube |
WO2010028371A1 (en) | 2008-09-05 | 2010-03-11 | Zubiate, Brett | Multi-linked endoscopic device with spherical distal assembly |
US8628544B2 (en) | 2008-09-23 | 2014-01-14 | Covidien Lp | Knife bar for surgical instrument |
US9011530B2 (en) | 2008-12-22 | 2015-04-21 | Valtech Cardio, Ltd. | Partially-adjustable annuloplasty structure |
US8940044B2 (en) | 2011-06-23 | 2015-01-27 | Valtech Cardio, Ltd. | Closure element for use with an annuloplasty structure |
US8147542B2 (en) | 2008-12-22 | 2012-04-03 | Valtech Cardio, Ltd. | Adjustable repair chords and spool mechanism therefor |
US8676290B2 (en) | 2010-05-11 | 2014-03-18 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Multi-directional catheter control handle |
US8556850B2 (en) | 2008-12-31 | 2013-10-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Shaft and handle for a catheter with independently-deflectable segments |
US8123721B2 (en) * | 2008-12-31 | 2012-02-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Catheter having independently-deflectable segments and method of its manufacture |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8821485B2 (en) * | 2009-01-29 | 2014-09-02 | Boston Scientific Scimed, Inc. | Employing a secondary sheath with an ablation catheter |
EP2398543A1 (en) | 2009-02-20 | 2011-12-28 | Boston Scientific Scimed, Inc. | Asymmetric dual directional steerable catheter sheath |
EP2424608B1 (en) | 2009-04-28 | 2014-03-19 | Avinger, Inc. | Guidewire support catheter |
CA2763324C (en) | 2009-05-28 | 2018-10-23 | Avinger, Inc. | Optical coherence tomography for biological imaging |
US20110112365A1 (en) * | 2009-06-03 | 2011-05-12 | Gyrus Acmi, Inc. | Endoscope shaft |
WO2011003006A2 (en) | 2009-07-01 | 2011-01-06 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
US8579801B2 (en) * | 2009-08-10 | 2013-11-12 | Gyrus Acmi, Inc. | Endoscope riveted deflection section frame |
US9011520B2 (en) | 2009-10-29 | 2015-04-21 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US20110166455A1 (en) * | 2010-01-07 | 2011-07-07 | Cully Edward H | Catheter |
EP2528518B1 (en) | 2010-01-26 | 2017-12-13 | Artack Medical (2013) Ltd. | Articulating medical instrument |
JP2011172766A (en) * | 2010-02-24 | 2011-09-08 | Fujifilm Corp | Torque transmission device |
US8870863B2 (en) | 2010-04-26 | 2014-10-28 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US9289147B2 (en) | 2010-05-11 | 2016-03-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Multi-directional flexible wire harness for medical devices |
CA2803992C (en) | 2010-07-01 | 2018-03-20 | Avinger, Inc. | Atherectomy catheters with longitudinally displaceable drive shafts |
US10548478B2 (en) | 2010-07-01 | 2020-02-04 | Avinger, Inc. | Balloon atherectomy catheters with imaging |
US11382653B2 (en) | 2010-07-01 | 2022-07-12 | Avinger, Inc. | Atherectomy catheter |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US10076327B2 (en) * | 2010-09-14 | 2018-09-18 | Evalve, Inc. | Flexible actuator mandrel for tissue apposition systems |
US20120073572A1 (en) * | 2010-09-24 | 2012-03-29 | Li Michael Y | Intubation Stylet & Endotracheal Tube |
US9084610B2 (en) | 2010-10-21 | 2015-07-21 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
EP3100696B1 (en) | 2010-10-25 | 2023-01-11 | Medtronic Ardian Luxembourg S.à.r.l. | Catheter apparatuses having multi-electrode arrays for renal neuromodulation |
WO2012106185A1 (en) | 2011-01-31 | 2012-08-09 | Boston Scientific Scimed, Inc. | Articulation section with locking |
US9901711B2 (en) * | 2011-02-16 | 2018-02-27 | Siemens Medical Solutions Usa, Inc. | Shape-controllable catheters and catheter system |
US9949754B2 (en) | 2011-03-28 | 2018-04-24 | Avinger, Inc. | Occlusion-crossing devices |
EP3135232B1 (en) | 2011-03-28 | 2018-05-02 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US9259240B2 (en) | 2011-03-29 | 2016-02-16 | Covidien Lp | Articulating surgical access system for laparoscopic surgery |
US9179933B2 (en) | 2011-03-29 | 2015-11-10 | Covidien Lp | Gear driven triangulation |
US8685003B2 (en) | 2011-03-29 | 2014-04-01 | Covidien Lp | Dual cable triangulation mechanism |
US9038880B1 (en) * | 2011-04-25 | 2015-05-26 | Cardica, Inc. | Articulated surgical instrument |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
EP2522307B1 (en) * | 2011-05-08 | 2020-09-30 | ITSO Medical AB | Device for delivery of medical devices to a cardiac valve |
USD726905S1 (en) | 2011-05-11 | 2015-04-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Control handle for a medical device |
US8968187B2 (en) | 2011-05-19 | 2015-03-03 | Covidien Lp | Articulating laparoscopic surgical access instrument |
US9017314B2 (en) | 2011-06-01 | 2015-04-28 | Covidien Lp | Surgical articulation assembly |
US9381010B2 (en) | 2011-06-27 | 2016-07-05 | Covidien Lp | Surgical instrument with adapter for facilitating multi-direction end effector articulation |
US8845517B2 (en) | 2011-06-27 | 2014-09-30 | Covidien Lp | Triangulation mechanism for a minimally invasive surgical device |
US20120330225A1 (en) * | 2011-06-27 | 2012-12-27 | Fresenius Medical Care Holdings, Inc. | Active Catheter |
US9545261B2 (en) * | 2011-07-29 | 2017-01-17 | Smith & Nephew, Inc. | Instrument guide |
US9119639B2 (en) * | 2011-08-09 | 2015-09-01 | DePuy Synthes Products, Inc. | Articulated cavity creator |
EP2768406B1 (en) * | 2011-10-17 | 2019-12-04 | Avinger, Inc. | Atherectomy catheters and non-contact actuation mechanism for catheters |
US9345406B2 (en) | 2011-11-11 | 2016-05-24 | Avinger, Inc. | Occlusion-crossing devices, atherectomy devices, and imaging |
US9585546B2 (en) * | 2011-11-21 | 2017-03-07 | Cook Medical Technologies Llc | Endoscope stabilization system |
US9757538B2 (en) | 2011-12-15 | 2017-09-12 | Imricor Medical Systems, Inc. | MRI compatible control handle for steerable sheath with audible, tactile and/or visual means |
WO2013090558A1 (en) | 2011-12-15 | 2013-06-20 | Imricor Medical Systems, Inc. | Mri compatible handle and steerable sheath |
US9821143B2 (en) | 2011-12-15 | 2017-11-21 | Imricor Medical Systems, Inc. | Steerable sheath including elastomeric member |
US9271701B2 (en) | 2012-01-09 | 2016-03-01 | Covidien Lp | Surgical articulation assembly |
US9808317B2 (en) | 2012-01-09 | 2017-11-07 | Covidien Lp | Pneumatic system for deployment of articulating arms for an access port |
US9226741B2 (en) * | 2012-01-09 | 2016-01-05 | Covidien Lp | Triangulation methods with hollow segments |
US9204869B2 (en) | 2012-01-09 | 2015-12-08 | Covidien Lp | Articulation control mechanisms |
US9956042B2 (en) | 2012-01-13 | 2018-05-01 | Vanderbilt University | Systems and methods for robot-assisted transurethral exploration and intervention |
US8419720B1 (en) | 2012-02-07 | 2013-04-16 | National Advanced Endoscopy Devices, Incorporated | Flexible laparoscopic device |
US9549720B2 (en) | 2012-04-20 | 2017-01-24 | Vanderbilt University | Robotic device for establishing access channel |
US9539726B2 (en) | 2012-04-20 | 2017-01-10 | Vanderbilt University | Systems and methods for safe compliant insertion and hybrid force/motion telemanipulation of continuum robots |
US9687303B2 (en) | 2012-04-20 | 2017-06-27 | Vanderbilt University | Dexterous wrists for surgical intervention |
CA2872189A1 (en) | 2012-05-11 | 2013-11-14 | William W. CHANG | Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods |
US9333650B2 (en) | 2012-05-11 | 2016-05-10 | Vanderbilt University | Method and system for contact detection and contact localization along continuum robots |
WO2013172972A1 (en) | 2012-05-14 | 2013-11-21 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
WO2013172970A1 (en) | 2012-05-14 | 2013-11-21 | Avinger, Inc. | Atherectomy catheters with imaging |
EP2849660B1 (en) | 2012-05-14 | 2021-08-25 | Avinger, Inc. | Atherectomy catheter drive assemblies |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
JP2015156879A (en) * | 2012-06-11 | 2015-09-03 | テルモ株式会社 | Medical device |
US8986225B2 (en) | 2012-08-02 | 2015-03-24 | Covidien Lp | Guidewire |
KR101364053B1 (en) * | 2012-08-03 | 2014-02-19 | 한국과학기술연구원 | Guide Tube for Microsurgical Instruments |
US11284916B2 (en) | 2012-09-06 | 2022-03-29 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US20140067048A1 (en) | 2012-09-06 | 2014-03-06 | Edwards Lifesciences Corporation | Heart Valve Sealing Devices |
US9498247B2 (en) | 2014-02-06 | 2016-11-22 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US10335173B2 (en) | 2012-09-06 | 2019-07-02 | Avinger, Inc. | Re-entry stylet for catheter |
US9044575B2 (en) | 2012-10-22 | 2015-06-02 | Medtronic Adrian Luxembourg S.a.r.l. | Catheters with enhanced flexibility and associated devices, systems, and methods |
CN104968287B (en) | 2012-10-22 | 2018-05-22 | 美敦力Af卢森堡有限责任公司 | Flexible conduit with improvement |
US9095321B2 (en) | 2012-11-21 | 2015-08-04 | Medtronic Ardian Luxembourg S.A.R.L. | Cryotherapeutic devices having integral multi-helical balloons and methods of making the same |
US20150351906A1 (en) | 2013-01-24 | 2015-12-10 | Mitraltech Ltd. | Ventricularly-anchored prosthetic valves |
US9439693B2 (en) | 2013-02-01 | 2016-09-13 | DePuy Synthes Products, Inc. | Steerable needle assembly for use in vertebral body augmentation |
US9339271B2 (en) * | 2013-03-14 | 2016-05-17 | C.R. Bard, Inc. | Articulating surgical instruments |
EP2967507B1 (en) | 2013-03-15 | 2018-09-05 | Avinger, Inc. | Tissue collection device for catheter |
US9066726B2 (en) | 2013-03-15 | 2015-06-30 | Medtronic Ardian Luxembourg S.A.R.L. | Multi-electrode apposition judgment using pressure elements |
WO2014142958A1 (en) | 2013-03-15 | 2014-09-18 | Avinger, Inc. | Optical pressure sensor assembly |
EP2967371A4 (en) | 2013-03-15 | 2016-12-07 | Avinger Inc | Chronic total occlusion crossing devices with imaging |
US9179974B2 (en) | 2013-03-15 | 2015-11-10 | Medtronic Ardian Luxembourg S.A.R.L. | Helical push wire electrode |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US9357984B2 (en) | 2013-04-23 | 2016-06-07 | Covidien Lp | Constant value gap stabilizer for articulating links |
EP2996754B1 (en) | 2013-05-18 | 2023-04-26 | Medtronic Ardian Luxembourg S.à.r.l. | Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices and systems |
JP6204085B2 (en) * | 2013-06-27 | 2017-09-27 | オリンパス株式会社 | Endoscopic treatment tool and endoscope system |
EP3019096B1 (en) | 2013-07-08 | 2023-07-05 | Avinger, Inc. | System for identification of elastic lamina to guide interventional therapy |
US20150073515A1 (en) | 2013-09-09 | 2015-03-12 | Medtronic Ardian Luxembourg S.a.r.I. | Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods |
EP3099377B1 (en) | 2014-01-27 | 2022-03-02 | Medtronic Ireland Manufacturing Unlimited Company | Neuromodulation catheters having jacketed neuromodulation elements and related devices |
MX2016010141A (en) | 2014-02-06 | 2017-04-06 | Avinger Inc | Atherectomy catheters and occlusion crossing devices. |
EP2918249B1 (en) | 2014-03-14 | 2020-04-29 | Venus MedTech (HangZhou), Inc. | Supraclavicular catheter system for transseptal access to the left atrium and left ventricle |
WO2015164280A1 (en) | 2014-04-24 | 2015-10-29 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters having braided shafts and associated systems and methods |
MX2017000303A (en) | 2014-07-08 | 2017-07-10 | Avinger Inc | High speed chronic total occlusion crossing devices. |
US10413708B2 (en) * | 2014-08-05 | 2019-09-17 | Jeffrey Thomas Loh | Swivel enhanced guidewire and related methods |
EP3238771B1 (en) | 2016-04-26 | 2018-10-31 | Jeffrey Thomas Loh | Swivel enhanced guidewire |
GB2536538B (en) | 2014-09-17 | 2018-07-18 | Cardiomech As | Anchor for implantation in body tissue |
EP3226952A1 (en) | 2014-12-01 | 2017-10-11 | Koninklijke Philips N.V. | Pre-curved steerable catheter with pull-wires for dexterous deflection control |
US10448931B2 (en) | 2015-01-15 | 2019-10-22 | Montefiore Medical Center | Transfemoral transcaval liver access and devices |
WO2016125160A1 (en) | 2015-02-05 | 2016-08-11 | Mitraltech Ltd. | Prosthetic valve with axially-sliding frames |
WO2016199305A1 (en) * | 2015-06-12 | 2016-12-15 | オリンパス株式会社 | Flexible tube inserting device |
US10568520B2 (en) | 2015-07-13 | 2020-02-25 | Avinger, Inc. | Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters |
US10335301B2 (en) | 2015-09-01 | 2019-07-02 | Cook Medical Technologies Llc | Modular handle comprising a trigger wire actuation mechanism for a prosthesis delivery device |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
US20180193608A1 (en) * | 2016-01-15 | 2018-07-12 | Cook Medical Technologies Llc | Modular medical guide wire assembly |
US10434288B2 (en) * | 2016-01-15 | 2019-10-08 | Cook Medical Technologies Llc | Locking medical guide wire |
JP6927986B2 (en) | 2016-01-25 | 2021-09-01 | アビンガー・インコーポレイテッドAvinger, Inc. | OCT imaging catheter with delay compensation |
CA3007670A1 (en) | 2016-01-29 | 2017-08-03 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
WO2017147041A1 (en) * | 2016-02-22 | 2017-08-31 | Arizona Board Of Regents On Behalf Of Arizona State University | Adjustable guidewire |
WO2017173370A1 (en) | 2016-04-01 | 2017-10-05 | Avinger, Inc. | Atherectomy catheter with serrated cutter |
EP3463123A4 (en) | 2016-06-03 | 2020-01-08 | Avinger, Inc. | Catheter device with detachable distal end |
JP7061080B2 (en) | 2016-06-30 | 2022-04-27 | アビンガー・インコーポレイテッド | Atherectomy catheter with a shaped distal tip |
US11185413B2 (en) | 2016-07-13 | 2021-11-30 | Medfree, Inc. | Tissue grasping devices and related methods |
EP3848003A1 (en) | 2016-08-10 | 2021-07-14 | Cardiovalve Ltd. | Prosthetic valve with concentric frames |
US10682192B2 (en) * | 2016-09-30 | 2020-06-16 | Intuitive Surgical Operations, Inc. | Variable-length guide apparatus for delivery of a flexible instrument and methods of use |
WO2018090148A1 (en) | 2016-11-21 | 2018-05-24 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
WO2018102718A1 (en) | 2016-12-02 | 2018-06-07 | Vanderbilt University | Steerable endoscope with continuum manipulator |
US10786651B2 (en) | 2017-03-07 | 2020-09-29 | Talon Medical, LLC | Steerable guide catheter |
US20190060618A1 (en) * | 2017-08-25 | 2019-02-28 | Acclarent, Inc. | Core wire assembly for guidewire |
CA3073834A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10967504B2 (en) | 2017-09-13 | 2021-04-06 | Vanderbilt University | Continuum robots with multi-scale motion through equilibrium modulation |
US11517715B2 (en) * | 2018-01-02 | 2022-12-06 | Biosense Webster (Israel) Ltd. | Deflectable medical probe |
WO2019143726A1 (en) | 2018-01-16 | 2019-07-25 | Medfree, Inc. | Tissue grasping devices and related methods |
US11957899B2 (en) * | 2018-02-15 | 2024-04-16 | Brown University | Coupled annulus and catheter system for placement of biocompatible brain electrodes and like devices |
US11406419B2 (en) * | 2018-10-29 | 2022-08-09 | Cardiovascular Systems, Inc. | System, device, and method for interrupted dual action (sanding and cutting) forces with continual maceration and aspiration |
EP3876870B1 (en) | 2018-11-08 | 2023-12-20 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
CA3135753C (en) | 2019-04-01 | 2023-10-24 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
US20200324090A1 (en) * | 2019-04-10 | 2020-10-15 | W. L. Gore & Associates, Inc. | Deployment system access sheath |
US11491006B2 (en) | 2019-04-10 | 2022-11-08 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
CN114051422A (en) * | 2019-05-17 | 2022-02-15 | 帕夫梅德有限公司 | Catheter device system and method of use |
AU2020279750B2 (en) | 2019-05-20 | 2023-07-13 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
EP3986332A4 (en) | 2019-06-20 | 2023-07-19 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
CN114449979A (en) | 2019-07-15 | 2022-05-06 | 埃瓦尔维公司 | Independent proximal element actuation method |
JP1666798S (en) * | 2019-10-10 | 2020-08-24 | ||
WO2021076356A1 (en) | 2019-10-18 | 2021-04-22 | Avinger, Inc. | Occlusion-crossing devices |
WO2024074643A1 (en) * | 2022-10-07 | 2024-04-11 | ETH Zürich | Steerable device for use inside of a mammalian body |
Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2108206A (en) * | 1937-03-09 | 1938-02-15 | Lillian Pearl Mecker | Tenaculum |
US3378010A (en) * | 1965-07-28 | 1968-04-16 | Coldling | Surgical clip with means for releasing the clamping pressure |
US3671979A (en) * | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US3874338A (en) * | 1972-10-09 | 1975-04-01 | Fritz Happel | Milking cup |
US4809695A (en) * | 1981-10-21 | 1989-03-07 | Owen M. Gwathmey | Suturing assembly and method |
US4917089A (en) * | 1988-08-29 | 1990-04-17 | Sideris Eleftherios B | Buttoned device for the transvenous occlusion of intracardiac defects |
US4994077A (en) * | 1989-04-21 | 1991-02-19 | Dobben Richard L | Artificial heart valve for implantation in a blood vessel |
US5108368A (en) * | 1990-01-04 | 1992-04-28 | Pilot Cardiovascular System, Inc. | Steerable medical device |
US5195968A (en) * | 1990-02-02 | 1993-03-23 | Ingemar Lundquist | Catheter steering mechanism |
US5209756A (en) * | 1989-11-03 | 1993-05-11 | Bahaa Botros Seedhom | Ligament fixation staple |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5312415A (en) * | 1992-09-22 | 1994-05-17 | Target Therapeutics, Inc. | Assembly for placement of embolic coils using frictional placement |
US5318525A (en) * | 1992-04-10 | 1994-06-07 | Medtronic Cardiorhythm | Steerable electrode catheter |
US5383886A (en) * | 1992-10-13 | 1995-01-24 | Kensey Nash Corporation | Methods and instruments for performing medical procedures percutaneously without a trocar |
US5403326A (en) * | 1993-02-01 | 1995-04-04 | The Regents Of The University Of California | Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux |
US5411552A (en) * | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5417700A (en) * | 1992-03-30 | 1995-05-23 | Thomas D. Egan | Automatic suturing and ligating device |
US5423858A (en) * | 1993-09-30 | 1995-06-13 | United States Surgical Corporation | Septoplasty fasteners and device for applying same |
US5423882A (en) * | 1991-12-26 | 1995-06-13 | Cordis-Webster, Inc. | Catheter having electrode with annular recess and method of using same |
US5507725A (en) * | 1992-12-23 | 1996-04-16 | Angeion Corporation | Steerable catheter |
US5520701A (en) * | 1993-06-16 | 1996-05-28 | Lerch; Karl-Dieter | Set for the treatment of vascular deformations |
US5618306A (en) * | 1994-02-14 | 1997-04-08 | Heartport, Inc. | Endoscopic microsurgical instruments and methods |
US5634932A (en) * | 1995-10-10 | 1997-06-03 | Industrial & Scientific Designs, Ltd. | Cantilever aneurysm clip system |
US5636634A (en) * | 1993-03-16 | 1997-06-10 | Ep Technologies, Inc. | Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes |
US5640955A (en) * | 1995-02-14 | 1997-06-24 | Daig Corporation | Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach |
US5713910A (en) * | 1992-09-04 | 1998-02-03 | Laurus Medical Corporation | Needle guidance system for endoscopic suture device |
US5716367A (en) * | 1995-10-18 | 1998-02-10 | Nissho Corporation | Catheter assembly for intracardiac suture |
US5715817A (en) * | 1993-06-29 | 1998-02-10 | C.R. Bard, Inc. | Bidirectional steering catheter |
US5719725A (en) * | 1995-11-30 | 1998-02-17 | Sanyo Electric Co., Ltd. | Disk playback device |
US5718725A (en) * | 1992-12-03 | 1998-02-17 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5741280A (en) * | 1994-01-18 | 1998-04-21 | Coral Medical | Knot tying method and apparatus |
US5749828A (en) * | 1995-12-22 | 1998-05-12 | Hewlett-Packard Company | Bending neck for use with invasive medical devices |
US5769812A (en) * | 1991-07-16 | 1998-06-23 | Heartport, Inc. | System for cardiac procedures |
US5772578A (en) * | 1995-09-14 | 1998-06-30 | Richard Wolf Gmbh | Endoscopic instrument |
US5855614A (en) * | 1993-02-22 | 1999-01-05 | Heartport, Inc. | Method and apparatus for thoracoscopic intracardiac procedures |
US5879307A (en) * | 1996-03-15 | 1999-03-09 | Pulse Metric, Inc. | Non-invasive method and apparatus for diagnosing and monitoring aortic valve abnormalities, such a aortic regurgitation |
US5885271A (en) * | 1997-03-14 | 1999-03-23 | Millennium Cardiac Strategies, Inc. | Device for regional immobilization of a compliant body |
US5916147A (en) * | 1997-09-22 | 1999-06-29 | Boury; Harb N. | Selectively manipulable catheter |
US6019722A (en) * | 1997-09-17 | 2000-02-01 | Guidant Corporation | Device to permit offpump beating heart coronary bypass surgery |
US6033378A (en) * | 1990-02-02 | 2000-03-07 | Ep Technologies, Inc. | Catheter steering mechanism |
US6077214A (en) * | 1998-07-29 | 2000-06-20 | Myocor, Inc. | Stress reduction apparatus and method |
US6190408B1 (en) * | 1998-03-05 | 2001-02-20 | The University Of Cincinnati | Device and method for restructuring the heart chamber geometry |
US6210432B1 (en) * | 1999-06-29 | 2001-04-03 | Jan Otto Solem | Device and method for treatment of mitral insufficiency |
US20020013571A1 (en) * | 1999-04-09 | 2002-01-31 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US6355030B1 (en) * | 1998-09-25 | 2002-03-12 | Cardiothoracic Systems, Inc. | Instruments and methods employing thermal energy for the repair and replacement of cardiac valves |
US20020035361A1 (en) * | 1999-06-25 | 2002-03-21 | Houser Russell A. | Apparatus and methods for treating tissue |
US6402781B1 (en) * | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US6406420B1 (en) * | 1997-01-02 | 2002-06-18 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
US20020077687A1 (en) * | 2000-12-14 | 2002-06-20 | Ahn Samuel S. | Catheter assembly for treating ischemic tissue |
US6519291B1 (en) * | 1998-02-03 | 2003-02-11 | Lucent Technologies Inc. | Reduction of interference in discrete multi-tone (DMT) based communications systems |
US20030063742A1 (en) * | 2001-09-28 | 2003-04-03 | Neufeld E. David | Method and apparatus for generating a strong random number for use in a security subsystem for a processor-based device |
US20030069570A1 (en) * | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
US20030069636A1 (en) * | 1999-06-30 | 2003-04-10 | Solem Jan Otto | Method for treatment of mitral insufficiency |
US20030069595A1 (en) * | 2001-10-05 | 2003-04-10 | Phung Trinh D. | Surgical punch device |
US20030074012A1 (en) * | 2000-10-10 | 2003-04-17 | Coalescent Surgical, Inc. | Minimally invasive annuloplasty procedure and apparatus |
US20030078654A1 (en) * | 2001-08-14 | 2003-04-24 | Taylor Daniel C. | Method and apparatus for improving mitral valve function |
US6556221B1 (en) * | 1998-07-01 | 2003-04-29 | Sony Corporation | Extended elements and mechanisms for displaying a rich graphical user interface in panel subunit |
US6562037B2 (en) * | 1998-02-12 | 2003-05-13 | Boris E. Paton | Bonding of soft biological tissues by passing high frequency electric current therethrough |
US20030105519A1 (en) * | 1997-09-04 | 2003-06-05 | Roland Fasol | Artificial chordae replacement |
US6575971B2 (en) * | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US20030120341A1 (en) * | 2001-12-21 | 2003-06-26 | Hani Shennib | Devices and methods of repairing cardiac valves |
US20040003819A1 (en) * | 1999-04-09 | 2004-01-08 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20040019377A1 (en) * | 2002-01-14 | 2004-01-29 | Taylor Daniel C. | Method and apparatus for reducing mitral regurgitation |
US20040019378A1 (en) * | 2001-04-24 | 2004-01-29 | Hlavka Edwin J. | Method and apparatus for performing catheter-based annuloplasty |
US20040024414A1 (en) * | 2000-06-20 | 2004-02-05 | Downing Stephen W. | Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures inside of a beating heart |
US20040039443A1 (en) * | 1999-06-30 | 2004-02-26 | Solem Jan Otto | Method and device for treatment of mitral insufficiency |
US6701929B2 (en) * | 1999-03-03 | 2004-03-09 | Hany Hussein | Device and method for treatment of congestive heart failure |
US6702826B2 (en) * | 2000-06-23 | 2004-03-09 | Viacor, Inc. | Automated annular plication for mitral valve repair |
US20040049211A1 (en) * | 2002-06-12 | 2004-03-11 | Mitral Interventions, Inc. | Method and apparatus for tissue connection |
US6709455B1 (en) * | 1998-08-14 | 2004-03-23 | Boston Scientific Scimed, Inc. | Stent-graft-membrane and method of making the same |
US6709362B2 (en) * | 2000-09-05 | 2004-03-23 | Toyota Jidosha Kabushiki Kaisha | Electric oil pump control device |
US20040073302A1 (en) * | 2002-02-05 | 2004-04-15 | Jonathan Rourke | Method and apparatus for improving mitral valve function |
US6723038B1 (en) * | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US6726716B2 (en) * | 2001-08-24 | 2004-04-27 | Edwards Lifesciences Corporation | Self-molding annuloplasty ring |
US20040088047A1 (en) * | 2000-02-02 | 2004-05-06 | Paul A. Spence | Heart valve repair apparatus and methods |
US20040097979A1 (en) * | 2002-11-14 | 2004-05-20 | Oleg Svanidze | Aortic valve implantation device |
US6740107B2 (en) * | 2001-12-19 | 2004-05-25 | Trimedyne, Inc. | Device for treatment of atrioventricular valve regurgitation |
US20040106989A1 (en) * | 2002-07-03 | 2004-06-03 | Wilson Robert F. | Leaflet reinforcement for regurgitant valves |
US6746471B2 (en) * | 1998-07-29 | 2004-06-08 | Myocor, Inc. | Transventricular implant tools and devices |
US20040111098A1 (en) * | 2002-09-02 | 2004-06-10 | Hallen Jan Ake | Obstetric vacuum extractor |
US6754510B2 (en) * | 2001-12-13 | 2004-06-22 | Superconductor Technologies, Inc. | MEMS-based bypass system for use with a HTS RF receiver |
US20040122448A1 (en) * | 2002-08-13 | 2004-06-24 | The General Hospital Corporation | Cardiac devices and methods for percutaneous repair of atrioventricular valves |
US6755777B2 (en) * | 1997-01-02 | 2004-06-29 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
US20050004583A1 (en) * | 1997-06-27 | 2005-01-06 | Oz Mehmet C. | Method and apparatus for circulatory valve repair |
US20050004668A1 (en) * | 2003-07-02 | 2005-01-06 | Flexcor, Inc. | Annuloplasty rings and methods for repairing cardiac valves |
US20050038508A1 (en) * | 2003-08-13 | 2005-02-17 | Shlomo Gabbay | Implantable cardiac prosthesis for mitigating prolapse of a heart valve |
US20050049698A1 (en) * | 2001-11-13 | 2005-03-03 | Bolling Steven F. | Methods of implanting a mitral valve annuloplasty ring to correct mitral regurgitation |
US20050055089A1 (en) * | 2000-09-20 | 2005-03-10 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus |
US20050059351A1 (en) * | 2002-08-30 | 2005-03-17 | Patrick Cauwels | User-specified outputs in mobile wireless communication devices and methods therefor |
US6875224B2 (en) * | 1999-10-13 | 2005-04-05 | Massachusetts General Hospital | Devices and methods for percutaneous mitral valve repair |
Family Cites Families (344)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2097018A (en) | 1936-07-17 | 1937-10-26 | Coleman R Chamberlin | Multiple purpose guide and retention clip |
US3296668A (en) | 1965-03-03 | 1967-01-10 | Winthrop J Aiken | Clip for sheets and the like |
US3557780A (en) * | 1967-04-20 | 1971-01-26 | Olympus Optical Co | Mechanism for controlling flexure of endoscope |
US3874388A (en) | 1973-02-12 | 1975-04-01 | Ochsner Med Found Alton | Shunt defect closure system |
GB1486351A (en) | 1975-06-06 | 1977-09-21 | Rocket Of London Ltd | Surgical clip applicator |
US4007743A (en) | 1975-10-20 | 1977-02-15 | American Hospital Supply Corporation | Opening mechanism for umbrella-like intravascular shunt defect closure device |
US4112951A (en) | 1976-01-26 | 1978-09-12 | Research Corporation | Surgical clip |
US4056854A (en) | 1976-09-28 | 1977-11-08 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Aortic heart valve catheter |
AU521676B2 (en) | 1977-02-23 | 1982-04-22 | Clark, Richard Edwin | Heart valve prosthesis |
US4297749A (en) | 1977-04-25 | 1981-11-03 | Albany International Corp. | Heart valve prosthesis |
US4235238A (en) | 1978-05-11 | 1980-11-25 | Olympus Optical Co., Ltd. | Apparatus for suturing coeliac tissues |
NL7906691A (en) | 1979-09-07 | 1981-03-10 | Jansen Anton | MEDICAL DEVICE FOR COUPLING TWO Bowel Sections, Auxiliary Device For Using It And Method Of Laying A Gut Knot Using This Device. |
US4578061A (en) | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
US4498476A (en) | 1981-08-27 | 1985-02-12 | Ethicon, Inc. | Non-metallic, bio-compatible hemostatic clips with interlocking latch means |
US4944295A (en) | 1981-10-21 | 1990-07-31 | Owen Gwathmay | Suturing assembly |
US4425908A (en) | 1981-10-22 | 1984-01-17 | Beth Israel Hospital | Blood clot filter |
US4487205A (en) | 1982-04-26 | 1984-12-11 | Ethicon, Inc. | Non-metallic, bio-compatible hemostatic clips |
US4484579A (en) | 1982-07-19 | 1984-11-27 | University Of Pittsburgh | Commissurotomy catheter apparatus and method |
US4458682A (en) | 1982-08-02 | 1984-07-10 | Ethicon, Inc. | Non-metallic, bio-compatible hemostatic clips (ring lock clips) |
US4510934A (en) | 1983-05-13 | 1985-04-16 | Batra Subhash K | Suture |
US4531522A (en) | 1983-06-20 | 1985-07-30 | Ethicon, Inc. | Two-piece tissue fastener with locking top and method for applying same |
DE3344934A1 (en) | 1983-12-13 | 1985-06-20 | Richard Wolf Gmbh, 7134 Knittlingen | ENDOSCOPE WITH DISTALLY DEFLECTABLE AUXILIARY INSTRUMENT |
GB8424582D0 (en) | 1984-09-28 | 1984-11-07 | Univ Glasgow | Heart valve prosthesis |
JPS6187434A (en) | 1984-10-04 | 1986-05-02 | Nec Corp | Portable radio equipment |
DE3504292C1 (en) | 1985-02-08 | 1986-07-24 | Richard Wolf Gmbh, 7134 Knittlingen | Instrument for endoscopic interventions, especially for percutaneous gallstone removal or gallbladder surgery |
US4742817A (en) * | 1985-05-15 | 1988-05-10 | Olympus Optical Co., Ltd. | Endoscopic apparatus having a bendable insertion section |
US4686963A (en) * | 1986-03-05 | 1987-08-18 | Circon Corporation | Torsion resistant vertebrated probe of simple construction |
CA1303298C (en) | 1986-08-06 | 1992-06-16 | Alain Carpentier | Flexible cardiac valvular support prosthesis |
US4777951A (en) | 1986-09-19 | 1988-10-18 | Mansfield Scientific, Inc. | Procedure and catheter instrument for treating patients for aortic stenosis |
US5542949A (en) | 1987-05-14 | 1996-08-06 | Yoon; Inbae | Multifunctional clip applier instrument |
US5478353A (en) | 1987-05-14 | 1995-12-26 | Yoon; Inbae | Suture tie device system and method for suturing anatomical tissue proximate an opening |
US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
JPH088933B2 (en) | 1987-07-10 | 1996-01-31 | 日本ゼオン株式会社 | Catheter |
US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US5447966A (en) | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
US5069679A (en) | 1989-02-16 | 1991-12-03 | Taheri Syde A | Method and apparatus for removing venous valves |
US5092872A (en) | 1989-07-28 | 1992-03-03 | Jacob Segalowitz | Valvulotome catheter |
US5047041A (en) | 1989-08-22 | 1991-09-10 | Samuels Peter B | Surgical apparatus for the excision of vein valves in situ |
US5049153A (en) | 1989-12-26 | 1991-09-17 | Nakao Naomi L | Endoscopic stapling device and method |
US5015249A (en) | 1989-12-26 | 1991-05-14 | Nakao Naomi L | Endoscopic stapling device and method |
DE69102515T2 (en) | 1990-04-02 | 1994-10-20 | Kanji Inoue | DEVICE FOR CLOSING A SHUTTER OPENING BY MEANS OF A NON-OPERATIONAL METHOD. |
DK124690D0 (en) | 1990-05-18 | 1990-05-18 | Henning Rud Andersen | FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION |
US5389102A (en) | 1990-09-13 | 1995-02-14 | United States Surgical Corporation | Apparatus and method for subcuticular stapling of body tissue |
US5282845A (en) | 1990-10-01 | 1994-02-01 | Ventritex, Inc. | Multiple electrode deployable lead |
US5042707A (en) | 1990-10-16 | 1991-08-27 | Taheri Syde A | Intravascular stapler, and method of operating same |
US5125758A (en) | 1990-12-06 | 1992-06-30 | Dewan Thomas E | Piercing clamp |
US5275578A (en) | 1991-01-11 | 1994-01-04 | Adams Andy W | Clip |
US5163955A (en) | 1991-01-24 | 1992-11-17 | Autogenics | Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment |
US5171252A (en) | 1991-02-05 | 1992-12-15 | Friedland Thomas W | Surgical fastening clip formed of a shape memory alloy, a method of making such a clip and a method of using such a clip |
US5329923A (en) | 1991-02-15 | 1994-07-19 | Lundquist Ingemar H | Torquable catheter |
US5251611A (en) | 1991-05-07 | 1993-10-12 | Zehel Wendell E | Method and apparatus for conducting exploratory procedures |
US5304131A (en) * | 1991-07-15 | 1994-04-19 | Paskar Larry D | Catheter |
US5571215A (en) | 1993-02-22 | 1996-11-05 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5452733A (en) | 1993-02-22 | 1995-09-26 | Stanford Surgical Technologies, Inc. | Methods for performing thoracoscopic coronary artery bypass |
US5370685A (en) | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
CA2078530A1 (en) | 1991-09-23 | 1993-03-24 | Jay Erlebacher | Percutaneous arterial puncture seal device and insertion tool therefore |
US5226911A (en) | 1991-10-02 | 1993-07-13 | Target Therapeutics | Vasoocclusion coil with attached fibrous element(s) |
DE4137218C1 (en) | 1991-11-13 | 1993-02-11 | Heidmueller, Harald, 5000 Koeln, De | |
US5271381A (en) * | 1991-11-18 | 1993-12-21 | Vision Sciences, Inc. | Vertebrae for a bending section of an endoscope |
US5242456A (en) | 1991-11-21 | 1993-09-07 | Kensey Nash Corporation | Apparatus and methods for clamping tissue and reflecting the same |
US5234437A (en) | 1991-12-12 | 1993-08-10 | Target Therapeutics, Inc. | Detachable pusher-vasoocclusion coil assembly with threaded coupling |
US5261916A (en) | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
AU3803193A (en) | 1991-12-30 | 1994-09-26 | Wellesley Research Associates, Inc. | Dental implant system and apparatus |
US5489297A (en) | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
US5314424A (en) | 1992-04-06 | 1994-05-24 | United States Surgical Corporation | Surgical instrument locking mechanism |
US5190554A (en) | 1992-04-08 | 1993-03-02 | Eastern Virginia Medical School | Appendix extractor |
US5254130A (en) | 1992-04-13 | 1993-10-19 | Raychem Corporation | Surgical device |
US5368601A (en) | 1992-04-30 | 1994-11-29 | Lasersurge, Inc. | Trocar wound closure device |
US5332402A (en) | 1992-05-12 | 1994-07-26 | Teitelbaum George P | Percutaneously-inserted cardiac valve |
US5389098A (en) | 1992-05-19 | 1995-02-14 | Olympus Optical Co., Ltd. | Surgical device for stapling and/or fastening body tissues |
US5658300A (en) | 1992-06-04 | 1997-08-19 | Olympus Optical Co., Ltd. | Tissue fixing surgical instrument, tissue-fixing device, and method of fixing tissues |
US5325845A (en) | 1992-06-08 | 1994-07-05 | Adair Edwin Lloyd | Steerable sheath for use with selected removable optical catheter |
US5306283A (en) | 1992-06-30 | 1994-04-26 | American Cyanamid Company | Two-part surgical ligation clip |
US5368606A (en) | 1992-07-02 | 1994-11-29 | Marlow Surgical Technologies, Inc. | Endoscopic instrument system |
US6048351A (en) | 1992-09-04 | 2000-04-11 | Scimed Life Systems, Inc. | Transvaginal suturing system |
US5250071A (en) | 1992-09-22 | 1993-10-05 | Target Therapeutics, Inc. | Detachable embolic coil assembly using interlocking clasps and method of use |
US5350397A (en) | 1992-11-13 | 1994-09-27 | Target Therapeutics, Inc. | Axially detachable embolic coil assembly |
CA2106126A1 (en) | 1992-09-23 | 1994-03-24 | Ian M. Scott | Bipolar surgical instruments |
US5500180A (en) | 1992-09-30 | 1996-03-19 | C. R. Bard, Inc. | Method of making a distensible dilatation balloon using a block copolymer |
US5330442A (en) | 1992-10-09 | 1994-07-19 | United States Surgical Corporation | Suture retaining clip |
US6283127B1 (en) | 1992-12-03 | 2001-09-04 | Wesley D. Sterman | Devices and methods for intracardiac procedures |
US5462527A (en) | 1993-06-29 | 1995-10-31 | C.R. Bard, Inc. | Actuator for use with steerable catheter |
US5417699A (en) | 1992-12-10 | 1995-05-23 | Perclose Incorporated | Device and method for the percutaneous suturing of a vascular puncture site |
US6036699A (en) | 1992-12-10 | 2000-03-14 | Perclose, Inc. | Device and method for suturing tissue |
US5403312A (en) | 1993-07-22 | 1995-04-04 | Ethicon, Inc. | Electrosurgical hemostatic device |
US5702825A (en) | 1992-12-22 | 1997-12-30 | Essilor International (Compagnie Generale D'optique) | Low yellow index polymer compositions, polymerizable compositions and lenses using said compositions |
US5569274A (en) | 1993-02-22 | 1996-10-29 | Heartport, Inc. | Endoscopic vascular clamping system and method |
US5425705A (en) | 1993-02-22 | 1995-06-20 | Stanford Surgical Technologies, Inc. | Thoracoscopic devices and methods for arresting the heart |
WO1994018893A1 (en) | 1993-02-22 | 1994-09-01 | Valleylab, Inc. | A laparoscopic dissection tension retractor device and method |
US5972030A (en) | 1993-02-22 | 1999-10-26 | Heartport, Inc. | Less-invasive devices and methods for treatment of cardiac valves |
US5980455A (en) | 1993-02-22 | 1999-11-09 | Heartport, Inc. | Method for manipulating a tissue structure within a thoracic cavity |
US5456400A (en) | 1993-04-22 | 1995-10-10 | United States Surgical Corporation | Apparatus and clip for fastening body tissue |
US5549565A (en) | 1993-07-13 | 1996-08-27 | Symbiosis Corporation | Reusable surgical trocar with disposable valve assembly |
US5527321A (en) | 1993-07-14 | 1996-06-18 | United States Surgical Corporation | Instrument for closing trocar puncture wounds |
US5450860A (en) | 1993-08-31 | 1995-09-19 | W. L. Gore & Associates, Inc. | Device for tissue repair and method for employing same |
US5472044A (en) | 1993-10-20 | 1995-12-05 | E. I. Du Pont De Nemours And Company | Method and apparatus for interacting a gas and liquid on a convoluted array of tubes |
US5423857A (en) * | 1993-11-02 | 1995-06-13 | Ethicon, Inc. | Three piece surgical staple |
US6203531B1 (en) | 1993-11-03 | 2001-03-20 | Daig Corporation | Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach |
US5527322A (en) | 1993-11-08 | 1996-06-18 | Perclose, Inc. | Device and method for suturing of internal puncture sites |
US5437681A (en) | 1994-01-13 | 1995-08-01 | Suturtek Inc. | Suturing instrument with thread management |
GB9400739D0 (en) | 1994-01-15 | 1994-03-16 | Femcare Ltd | Medical clip |
US5359994A (en) | 1994-01-24 | 1994-11-01 | Welch Allyn, Inc. | Proximal steering cable adjustment |
CA2141911C (en) | 1994-02-24 | 2002-04-23 | Jude S. Sauer | Surgical crimping device and method of use |
US5431666A (en) | 1994-02-24 | 1995-07-11 | Lasersurge, Inc. | Surgical suture instrument |
US5476470A (en) | 1994-04-15 | 1995-12-19 | Fitzgibbons, Jr.; Robert J. | Trocar site suturing device |
US5478309A (en) | 1994-05-27 | 1995-12-26 | William P. Sweezer, Jr. | Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery |
DE4447658C2 (en) | 1994-05-28 | 1996-12-19 | Karlsruhe Forschzent | Thread for constructing surgical seam |
US5732872A (en) | 1994-06-17 | 1998-03-31 | Heartport, Inc. | Surgical stapling instrument |
US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
US5593435A (en) | 1994-07-29 | 1997-01-14 | Baxter International Inc. | Distensible annuloplasty ring for surgical remodelling of an atrioventricular valve and nonsurgical method for post-implantation distension thereof to accommodate patient growth |
US5601576A (en) | 1994-08-10 | 1997-02-11 | Heartport Inc. | Surgical knot pusher and method of use |
US5593424A (en) | 1994-08-10 | 1997-01-14 | Segmed, Inc. | Apparatus and method for reducing and stabilizing the circumference of a vascular structure |
US5456684A (en) | 1994-09-08 | 1995-10-10 | Hutchinson Technology Incorporated | Multifunctional minimally invasive surgical instrument |
US5599305A (en) | 1994-10-24 | 1997-02-04 | Cardiovascular Concepts, Inc. | Large-diameter introducer sheath having hemostasis valve and removable steering mechanism |
US5814029A (en) | 1994-11-03 | 1998-09-29 | Daig Corporation | Guiding introducer system for use in ablation and mapping procedures in the left ventricle |
US5487746A (en) | 1994-11-23 | 1996-01-30 | Yu; George W. | Surgical clip having a longitudinal opening through which clamped tissue protrudes |
US5690671A (en) | 1994-12-13 | 1997-11-25 | Micro Interventional Systems, Inc. | Embolic elements and methods and apparatus for their delivery |
US5620452A (en) | 1994-12-22 | 1997-04-15 | Yoon; Inbae | Surgical clip with ductile tissue penetrating members |
US5609598A (en) | 1994-12-30 | 1997-03-11 | Vnus Medical Technologies, Inc. | Method and apparatus for minimally invasive treatment of chronic venous insufficiency |
US6540755B2 (en) | 1995-02-14 | 2003-04-01 | Daig Corporation | Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach |
US5695504A (en) | 1995-02-24 | 1997-12-09 | Heartport, Inc. | Devices and methods for performing a vascular anastomosis |
JPH08231444A (en) | 1995-02-28 | 1996-09-10 | Daikin Ind Ltd | Production of 1,1,3,3-pentafluoropropane |
US5695505A (en) | 1995-03-09 | 1997-12-09 | Yoon; Inbae | Multifunctional spring clips and cartridges and applicators therefor |
US5571085A (en) | 1995-03-24 | 1996-11-05 | Electro-Catheter Corporation | Steerable open lumen catheter |
AU708976B2 (en) | 1995-03-30 | 1999-08-19 | Edwards Lifesciences Ag | System and methods for performing endovascular procedures |
US5849005A (en) | 1995-06-07 | 1998-12-15 | Heartport, Inc. | Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity |
US5639277A (en) | 1995-04-28 | 1997-06-17 | Target Therapeutics, Inc. | Embolic coils with offset helical and twisted helical shapes |
US5540705A (en) | 1995-05-19 | 1996-07-30 | Suturtek, Inc. | Suturing instrument with thread management |
US6210337B1 (en) * | 1995-06-07 | 2001-04-03 | Atl Ultrasound Inc. | Ultrasonic endoscopic probe |
US5846253A (en) | 1995-07-14 | 1998-12-08 | C. R. Bard, Inc. | Wound closure apparatus and method |
US5860990A (en) | 1995-08-24 | 1999-01-19 | Nr Medical, Inc. | Method and apparatus for suturing |
US6117144A (en) | 1995-08-24 | 2000-09-12 | Sutura, Inc. | Suturing device and method for sealing an opening in a blood vessel or other biological structure |
US6562052B2 (en) | 1995-08-24 | 2003-05-13 | Sutura, Inc. | Suturing device and method |
US5722421A (en) * | 1995-09-15 | 1998-03-03 | Symbiosis Corporation | Clevis having deflection limiting stops for use in an endoscopic biopsy forceps instrument |
US5797927A (en) | 1995-09-22 | 1998-08-25 | Yoon; Inbae | Combined tissue clamping and suturing instrument |
US5810876A (en) | 1995-10-03 | 1998-09-22 | Akos Biomedical, Inc. | Flexible forceps device |
US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
DE69612507T2 (en) | 1995-10-30 | 2001-08-09 | Childrens Medical Center | SELF-CENTERING, SHIELD-LIKE DEVICE FOR CLOSING A SEPTAL DEFECT |
US5855271A (en) | 1995-11-03 | 1999-01-05 | T. K. F., Inc. | Noise and wear reducing apparatus for endless conveyors |
US5704898A (en) * | 1995-11-17 | 1998-01-06 | Circon Corporation | Articulation mechanism for an endoscope |
US5823955A (en) | 1995-11-20 | 1998-10-20 | Medtronic Cardiorhythm | Atrioventricular valve tissue ablation catheter and method |
US5662704A (en) | 1995-12-01 | 1997-09-02 | Medtronic, Inc. | Physiologic mitral valve bioprosthesis |
US5725556A (en) | 1995-12-15 | 1998-03-10 | M & R Medical, Inc. | Suture locking apparatus |
US5810853A (en) | 1996-01-16 | 1998-09-22 | Yoon; Inbae | Knotting element for use in suturing anatomical tissue and methods therefor |
US6015417A (en) | 1996-01-25 | 2000-01-18 | Reynolds, Jr.; Walker | Surgical fastener |
US6182664B1 (en) | 1996-02-19 | 2001-02-06 | Edwards Lifesciences Corporation | Minimally invasive cardiac valve surgery procedure |
US5891160A (en) | 1996-02-23 | 1999-04-06 | Cardiovascular Technologies, Llc | Fastener delivery and deployment mechanism and method for placing the fastener in minimally invasive surgery |
US6402780B2 (en) | 1996-02-23 | 2002-06-11 | Cardiovascular Technologies, L.L.C. | Means and method of replacing a heart valve in a minimally invasive manner |
US6162233A (en) | 1996-02-23 | 2000-12-19 | Cardiovascular Technologies, Llc | Wire fasteners for use in minimally invasive surgery and means and methods for handling those fasteners |
JP3661267B2 (en) * | 1996-03-18 | 2005-06-15 | フジノン株式会社 | Endoscope flexible tube |
US5853422A (en) | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US5769859A (en) | 1996-04-09 | 1998-06-23 | Dorsey; William R. | Umbilical scissors |
US6110145A (en) | 1996-04-16 | 2000-08-29 | Cardeon Corporation | Catheter system for surgical access and circulatory support of the heart |
US5738649A (en) | 1996-04-16 | 1998-04-14 | Cardeon Corporation | Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart |
US6149660A (en) | 1996-04-22 | 2000-11-21 | Vnus Medical Technologies, Inc. | Method and apparatus for delivery of an appliance in a vessel |
US5662681A (en) | 1996-04-23 | 1997-09-02 | Kensey Nash Corporation | Self locking closure for sealing percutaneous punctures |
US5706824A (en) * | 1996-05-20 | 1998-01-13 | Symbiosis Corporation | Endoscopic biopsy forceps instrument having a constant force spring biasing the jaws closed |
US5827237A (en) | 1996-06-17 | 1998-10-27 | Cardeon Corporation | Dual lumen catheter with controlled antegrade and retrograde fluid flow |
US6059757A (en) | 1996-06-18 | 2000-05-09 | Cardeon | Single lumen catheter with controlled antegrade and retrograde flow |
CA2258641A1 (en) | 1996-06-17 | 1997-12-24 | Cardeon Corporation | Externally valved catheter for controlled antegrade and retrograde fluid flow |
US5833671A (en) | 1996-06-17 | 1998-11-10 | Cardeon Corporation | Triple lumen catheter with controllable antegrade and retrograde fluid flow |
US6001796A (en) | 1996-07-03 | 1999-12-14 | Alliedsignal Inc. | Azeotrope-like compositions of 1,1,1,3,3-pentafluoropropane and hydrogen fluoride |
US5820592A (en) | 1996-07-16 | 1998-10-13 | Hammerslag; Gary R. | Angiographic and/or guide catheter |
US5782845A (en) | 1996-07-31 | 1998-07-21 | Shewchuk; Dwight | Trocar site suturing device |
US5820631A (en) | 1996-08-01 | 1998-10-13 | Nr Medical, Inc. | Device and method for suturing tissue adjacent to a blood vessel |
US6068628A (en) | 1996-08-20 | 2000-05-30 | Oratec Interventions, Inc. | Apparatus for treating chondromalacia |
WO1998007375A1 (en) | 1996-08-22 | 1998-02-26 | The Trustees Of Columbia University | Endovascular flexible stapling device |
US5713911A (en) | 1996-10-03 | 1998-02-03 | United States Surgical Corporation | Surgical clip |
IL119911A (en) | 1996-12-25 | 2001-03-19 | Niti Alloys Tech Ltd | Surgical clip |
US6074401A (en) | 1997-01-09 | 2000-06-13 | Coalescent Surgical, Inc. | Pinned retainer surgical fasteners, instruments and methods for minimally invasive vascular and endoscopic surgery |
US5928224A (en) | 1997-01-24 | 1999-07-27 | Hearten Medical, Inc. | Device for the treatment of damaged heart valve leaflets and methods of using the device |
US5916213A (en) | 1997-02-04 | 1999-06-29 | Medtronic, Inc. | Systems and methods for tissue mapping and ablation |
US6056769A (en) | 1997-02-11 | 2000-05-02 | Biointerventional Corporation | Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method |
US5972020A (en) | 1997-02-14 | 1999-10-26 | Cardiothoracic Systems, Inc. | Surgical instrument for cardiac valve repair on the beating heart |
US5989284A (en) | 1997-02-18 | 1999-11-23 | Hearten Medical, Inc. | Method and device for soft tissue modification |
US5957949A (en) | 1997-05-01 | 1999-09-28 | World Medical Manufacturing Corp. | Percutaneous placement valve stent |
US5876399A (en) * | 1997-05-28 | 1999-03-02 | Irvine Biomedical, Inc. | Catheter system and methods thereof |
US5810849A (en) | 1997-06-09 | 1998-09-22 | Cardiologics, L.L.C. | Device and method for suturing blood vessels and the like |
IT1293068B1 (en) | 1997-07-01 | 1999-02-11 | Kempro Italiana S R L | PROCEDURE FOR OBTAINING A HIGH CONCENTRATION COLLOIDAL SILICA SUSPENSION AND PRODUCT SO OBTAINED |
US5944733A (en) | 1997-07-14 | 1999-08-31 | Target Therapeutics, Inc. | Controlled detachable vasoocclusive member using mechanical junction and friction-enhancing member |
US5910148A (en) | 1997-08-06 | 1999-06-08 | Mitek Surgical Products, Inc. | Suture retrograder |
WO1999007354A2 (en) | 1997-08-08 | 1999-02-18 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US6088889A (en) | 1997-09-03 | 2000-07-18 | Edward Elson | Clamp operable as a hemostasis valve |
US6123699A (en) | 1997-09-05 | 2000-09-26 | Cordis Webster, Inc. | Omni-directional steerable catheter |
US5954732A (en) | 1997-09-10 | 1999-09-21 | Hart; Charles C. | Suturing apparatus and method |
FR2768324B1 (en) | 1997-09-12 | 1999-12-10 | Jacques Seguin | SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER |
US6063106A (en) | 1997-09-19 | 2000-05-16 | Gibson; William Frits Stewart | Surgical spacer |
US6086600A (en) | 1997-11-03 | 2000-07-11 | Symbiosis Corporation | Flexible endoscopic surgical instrument for invagination and fundoplication |
US6187003B1 (en) | 1997-11-12 | 2001-02-13 | Sherwood Services Ag | Bipolar electrosurgical instrument for sealing vessels |
US6332893B1 (en) | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
JP4187411B2 (en) * | 1998-01-30 | 2008-11-26 | セント ジュード メディカル エーティージー, インコーポレイテッド | Device for use in closing a septal defect |
US6126658A (en) | 1998-02-19 | 2000-10-03 | Baker; James A. | Radiofrequency medical instrument and methods for vessel welding |
US7214230B2 (en) | 1998-02-24 | 2007-05-08 | Hansen Medical, Inc. | Flexible instrument |
US6099553A (en) | 1998-05-21 | 2000-08-08 | Applied Medical Resources Corporation | Suture clinch |
US6143024A (en) | 1998-06-04 | 2000-11-07 | Sulzer Carbomedics Inc. | Annuloplasty ring having flexible anterior portion |
US6165164A (en) | 1999-03-29 | 2000-12-26 | Cordis Corporation | Catheter for injecting therapeutic and diagnostic agents |
US6599311B1 (en) | 1998-06-05 | 2003-07-29 | Broncus Technologies, Inc. | Method and assembly for lung volume reduction |
US6283962B1 (en) | 1998-06-08 | 2001-09-04 | Quantum Therapeutics Corp. | Device for valvular annulus treatment and methods thereof |
US6250308B1 (en) | 1998-06-16 | 2001-06-26 | Cardiac Concepts, Inc. | Mitral valve annuloplasty ring and method of implanting |
US6630001B2 (en) | 1998-06-24 | 2003-10-07 | International Heart Institute Of Montana Foundation | Compliant dehyrated tissue for implantation and process of making the same |
US6066146A (en) | 1998-06-24 | 2000-05-23 | Carroll; Brendan J. | Laparascopic incision closure device |
US6322559B1 (en) | 1998-07-06 | 2001-11-27 | Vnus Medical Technologies, Inc. | Electrode catheter having coil structure |
US6165183A (en) | 1998-07-15 | 2000-12-26 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6379345B1 (en) | 1998-07-15 | 2002-04-30 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of vascular calcified lesions |
US7569062B1 (en) | 1998-07-15 | 2009-08-04 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6547821B1 (en) | 1998-07-16 | 2003-04-15 | Cardiothoracic Systems, Inc. | Surgical procedures and devices for increasing cardiac output of the heart |
US6267781B1 (en) | 1998-08-31 | 2001-07-31 | Quantum Therapeutics Corp. | Medical device and methods for treating valvular annulus |
US6159240A (en) | 1998-08-31 | 2000-12-12 | Medtronic, Inc. | Rigid annuloplasty device that becomes compliant after implantation |
WO2000012168A1 (en) | 1998-09-01 | 2000-03-09 | Cardeon Corporation | System and methods for catheter procedures with circulatory support in high risk patients |
US6203553B1 (en) | 1999-09-08 | 2001-03-20 | United States Surgical | Stapling apparatus and method for heart valve replacement |
US6368326B1 (en) | 1998-09-28 | 2002-04-09 | Daos Limited | Internal cord fixation device |
US6685627B2 (en) | 1998-10-09 | 2004-02-03 | Swaminathan Jayaraman | Modification of properties and geometry of heart tissue to influence heart function |
US6319250B1 (en) | 1998-11-23 | 2001-11-20 | C.R. Bard, Inc | Tricuspid annular grasp catheter |
US6210419B1 (en) | 1998-12-18 | 2001-04-03 | Aesculap Ag & Co. Kg | Surgical clip |
US6558418B2 (en) | 1999-01-26 | 2003-05-06 | Edwards Lifesciences Corporation | Flexible heart valve |
WO2000044313A1 (en) | 1999-01-27 | 2000-08-03 | Viacor Incorporated | Cardiac valve procedure methods and devices |
US6136010A (en) | 1999-03-04 | 2000-10-24 | Perclose, Inc. | Articulating suturing device and method |
US6267746B1 (en) | 1999-03-22 | 2001-07-31 | Biosense Webster, Inc. | Multi-directional steerable catheters and control handles |
JP3425387B2 (en) | 1999-03-29 | 2003-07-14 | 有限会社タカタデザインラボ | Fixture for goods |
WO2000059382A1 (en) | 1999-04-01 | 2000-10-12 | Bjerken David B | Vacuum-assisted remote suture placement system |
US20040044350A1 (en) * | 1999-04-09 | 2004-03-04 | Evalve, Inc. | Steerable access sheath and methods of use |
US7226467B2 (en) | 1999-04-09 | 2007-06-05 | Evalve, Inc. | Fixation device delivery catheter, systems and methods of use |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US10327743B2 (en) | 1999-04-09 | 2019-06-25 | Evalve, Inc. | Device and methods for endoscopic annuloplasty |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US6860179B2 (en) | 1999-05-03 | 2005-03-01 | Irwin Industrial Tool Company | Clamp device |
US6709382B1 (en) * | 1999-05-04 | 2004-03-23 | Simon Marcus Horner | Cardiac assist method and apparatus |
US6206907B1 (en) | 1999-05-07 | 2001-03-27 | Cardia, Inc. | Occlusion device with stranded wire support arms |
CA2373636A1 (en) | 1999-05-11 | 2000-11-16 | Craig Berky | Surgical clamp devices and methods especially useful in cardiac surgery |
US6165204A (en) | 1999-06-11 | 2000-12-26 | Scion International, Inc. | Shaped suture clip, appliance and method therefor |
US6669687B1 (en) | 1999-06-25 | 2003-12-30 | Vahid Saadat | Apparatus and methods for treating tissue |
DE19932565A1 (en) | 1999-07-13 | 2001-01-18 | Henkel Kgaa | Agent for dyeing keratin fibers |
US6299637B1 (en) | 1999-08-20 | 2001-10-09 | Samuel M. Shaolian | Transluminally implantable venous valve |
US6231561B1 (en) | 1999-09-20 | 2001-05-15 | Appriva Medical, Inc. | Method and apparatus for closing a body lumen |
US6306133B1 (en) | 1999-10-02 | 2001-10-23 | Quantum Cor Incorporated | Ablation catheter system and methods for repairing a valvular annulus |
US6485489B2 (en) | 1999-10-02 | 2002-11-26 | Quantum Cor, Inc. | Catheter system for repairing a mitral valve annulus |
FR2799364B1 (en) * | 1999-10-12 | 2001-11-23 | Jacques Seguin | MINIMALLY INVASIVE CANCELING DEVICE |
AU5598300A (en) | 1999-10-13 | 2001-04-23 | Jeffrey E. Yeung | Non-invasive and minimally invasive methods and devices for treating urinary incontinence or obstruction |
US6491511B1 (en) | 1999-10-14 | 2002-12-10 | The International Heart Institute Of Montana Foundation | Mold to form stent-less replacement heart valves from biological membranes |
US6352708B1 (en) | 1999-10-14 | 2002-03-05 | The International Heart Institute Of Montana Foundation | Solution and method for treating autologous tissue for implant operation |
US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
US6626930B1 (en) | 1999-10-21 | 2003-09-30 | Edwards Lifesciences Corporation | Minimally invasive mitral valve repair method and apparatus |
EP1674040A3 (en) | 1999-10-21 | 2007-09-19 | Edwards Lifesciences Corporation | Minimally invasive mitral valve repair |
US6533767B2 (en) | 2000-03-20 | 2003-03-18 | Corazon Technologies, Inc. | Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same |
US6926730B1 (en) | 2000-10-10 | 2005-08-09 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
US6641592B1 (en) | 1999-11-19 | 2003-11-04 | Lsi Solutions, Inc. | System for wound closure |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
EP1239795B1 (en) | 1999-12-23 | 2006-12-06 | Edwards Lifesciences Corporation | Enhanced visualization of medical implants |
AU2001229476A1 (en) | 2000-01-14 | 2001-07-24 | Viacor Incorporated | Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same |
US20010010005A1 (en) | 2000-01-24 | 2001-07-26 | Kammerer Gene W. | Meniscal repair device |
US7011682B2 (en) | 2000-01-31 | 2006-03-14 | Edwards Lifesciences Ag | Methods and apparatus for remodeling an extravascular tissue structure |
AU2001233227A1 (en) | 2000-02-02 | 2001-08-14 | Robert V. Snyders | Artificial heart valve |
TW465542U (en) | 2000-03-14 | 2001-11-21 | Tange Seiki Taichung Co Ltd | Improved structure for bearing alignment of concealed operation head joint of bicycle |
EP1294422B1 (en) | 2000-03-20 | 2010-02-24 | Cordis Corporation | Medical System for Reducing Vascular Occlusions |
US6858005B2 (en) * | 2000-04-03 | 2005-02-22 | Neo Guide Systems, Inc. | Tendon-driven endoscope and methods of insertion |
US6530897B2 (en) | 2000-04-28 | 2003-03-11 | Mahase Nardeo | Steerable medical catheter with bendable encapsulated metal spring tip fused to polymeric shaft |
US7083628B2 (en) | 2002-09-03 | 2006-08-01 | Edwards Lifesciences Corporation | Single catheter mitral valve repair device and method for use |
US6743239B1 (en) | 2000-05-25 | 2004-06-01 | St. Jude Medical, Inc. | Devices with a bendable tip for medical procedures |
US6730016B1 (en) | 2000-06-12 | 2004-05-04 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
US6902522B1 (en) | 2000-06-12 | 2005-06-07 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
US6358277B1 (en) | 2000-06-21 | 2002-03-19 | The International Heart Institute Of Montana Foundation | Atrio-ventricular valvular device |
AU2001271667A1 (en) | 2000-06-30 | 2002-01-14 | Viacor Incorporated | Method and apparatus for performing a procedure on a cardiac valve |
SE0002878D0 (en) | 2000-08-11 | 2000-08-11 | Kimblad Ola | Device and method of treatment of atrioventricular regurgitation |
US6572652B2 (en) | 2000-08-29 | 2003-06-03 | Venpro Corporation | Method and devices for decreasing elevated pulmonary venous pressure |
WO2002019951A1 (en) | 2000-09-07 | 2002-03-14 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US20020035381A1 (en) | 2000-09-18 | 2002-03-21 | Cameron Health, Inc. | Subcutaneous electrode with improved contact shape for transthoracic conduction |
US20050228422A1 (en) | 2002-11-26 | 2005-10-13 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools |
US7033374B2 (en) | 2000-09-26 | 2006-04-25 | Microvention, Inc. | Microcoil vaso-occlusive device with multi-axis secondary configuration |
JP3600194B2 (en) * | 2000-10-02 | 2004-12-08 | オリンパス株式会社 | Endoscope |
US6616684B1 (en) | 2000-10-06 | 2003-09-09 | Myocor, Inc. | Endovascular splinting devices and methods |
US6533796B1 (en) | 2000-10-11 | 2003-03-18 | Lsi Solutions, Inc. | Loader for surgical suturing instrument |
US6508828B1 (en) | 2000-11-03 | 2003-01-21 | Radi Medical Systems Ab | Sealing device and wound closure device |
US7591826B2 (en) | 2000-12-28 | 2009-09-22 | Cardiac Dimensions, Inc. | Device implantable in the coronary sinus to provide mitral valve therapy |
US6810882B2 (en) | 2001-01-30 | 2004-11-02 | Ev3 Santa Rosa, Inc. | Transluminal mitral annuloplasty |
CA2433881C (en) | 2001-01-30 | 2009-08-18 | Randall T. Lashinski | Medical system and method for remodeling an extravascular tissue structure |
US6790231B2 (en) | 2001-02-05 | 2004-09-14 | Viacor, Inc. | Apparatus and method for reducing mitral regurgitation |
JP4184794B2 (en) | 2001-02-05 | 2008-11-19 | ビアカー・インコーポレーテッド | Method and apparatus for improving mitral valve function |
US20020107531A1 (en) | 2001-02-06 | 2002-08-08 | Schreck Stefan G. | Method and system for tissue repair using dual catheters |
JP2001239212A (en) | 2001-02-06 | 2001-09-04 | Matsushita Electric Ind Co Ltd | Vibration generating motor |
US7842050B2 (en) | 2001-02-26 | 2010-11-30 | Diduch David R | Suture passing devices |
JP4295925B2 (en) | 2001-03-01 | 2009-07-15 | Hoya株式会社 | Bipolar high-frequency treatment instrument for endoscope |
US6585761B2 (en) | 2001-03-01 | 2003-07-01 | Syde A. Taheri | Prosthetic vein valve and method |
US20060069429A1 (en) | 2001-04-24 | 2006-03-30 | Spence Paul A | Tissue fastening systems and methods utilizing magnetic guidance |
WO2002092148A2 (en) | 2001-05-17 | 2002-11-21 | The Regents Of The University Of California | Retrieval catheter |
DE10129525A1 (en) | 2001-06-21 | 2003-01-09 | Basf Ag | Multimodal polyamides, polyesters and polyester amides |
DE60225303T2 (en) * | 2001-08-31 | 2009-02-26 | Mitral Interventions, Redwood City | DEVICE FOR A HEART LAPSE REPAIR |
US20030050693A1 (en) * | 2001-09-10 | 2003-03-13 | Quijano Rodolfo C. | Minimally invasive delivery system for annuloplasty rings |
FR2829922B1 (en) | 2001-09-21 | 2004-06-18 | Sofradim Production | COMPLETE AND UNIVERSAL IMPLANT FOR THE REPAIR OF HERNIA BY ANTERIOR |
CA2455444A1 (en) | 2001-10-01 | 2003-04-10 | Ample Medical, Inc. | Methods and devices for heart valve treatments |
US7144363B2 (en) | 2001-10-16 | 2006-12-05 | Extensia Medical, Inc. | Systems for heart treatment |
US6949122B2 (en) | 2001-11-01 | 2005-09-27 | Cardiac Dimensions, Inc. | Focused compression mitral valve device and method |
US6976995B2 (en) | 2002-01-30 | 2005-12-20 | Cardiac Dimensions, Inc. | Fixed length anchor and pull mitral valve device and method |
US6908478B2 (en) | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US20030120340A1 (en) | 2001-12-26 | 2003-06-26 | Jan Liska | Mitral and tricuspid valve repair |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7150750B2 (en) | 2002-01-10 | 2006-12-19 | Boston Scientific Scimed, Inc. | Method and device for endoscopic suturing |
EP1478299B1 (en) | 2002-02-27 | 2009-12-30 | Dentsply International, Inc. | Dental handpiece with improved grease retention |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US7004958B2 (en) | 2002-03-06 | 2006-02-28 | Cardiac Dimensions, Inc. | Transvenous staples, assembly and method for mitral valve repair |
US6797001B2 (en) | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
US7094244B2 (en) | 2002-03-26 | 2006-08-22 | Edwards Lifesciences Corporation | Sequential heart valve leaflet repair device and method of use |
US7335221B2 (en) | 2002-04-12 | 2008-02-26 | Ethicon, Inc. | Suture anchoring and tensioning device and method for using same |
US7497822B1 (en) | 2003-04-10 | 2009-03-03 | Torax Medical, Inc. | Stomach reduction methods and apparatus |
US6986775B2 (en) | 2002-06-13 | 2006-01-17 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US8287555B2 (en) | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US8172856B2 (en) | 2002-08-02 | 2012-05-08 | Cedars-Sinai Medical Center | Methods and apparatus for atrioventricular valve repair |
EP2191792B1 (en) | 2002-08-29 | 2015-10-21 | St. Jude Medical, Cardiology Division, Inc. | Implantable devices for controlling the internal circumference of an anatomic orifice or lumen |
AU2003277118A1 (en) | 2002-10-01 | 2004-04-23 | Ample Medical, Inc. | Devices for retaining native heart valve leaflet |
JP2006501033A (en) | 2002-10-01 | 2006-01-12 | アンプル メディカル, インコーポレイテッド | Device, system and method for reshaping a heart valve annulus |
US20040133062A1 (en) | 2002-10-11 | 2004-07-08 | Suresh Pai | Minimally invasive cardiac force transfer structures |
US7087064B1 (en) | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
DE10249415B3 (en) | 2002-10-23 | 2004-03-25 | Siemens Ag | Motor vehicle has occupant medical support system with system controlling and/or interrogating data processor, arrangement for requesting person to carry out action and/or identification arrangement |
AU2003285943B2 (en) | 2002-10-24 | 2008-08-21 | Boston Scientific Limited | Venous valve apparatus and method |
AU2003290979A1 (en) | 2002-11-15 | 2004-06-15 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method and device for catheter-based repair of cardiac valves |
US6945978B1 (en) | 2002-11-15 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | Heart valve catheter |
US7485143B2 (en) | 2002-11-15 | 2009-02-03 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
US20040133240A1 (en) | 2003-01-07 | 2004-07-08 | Cardiac Dimensions, Inc. | Electrotherapy system, device, and method for treatment of cardiac valve dysfunction |
US7381210B2 (en) | 2003-03-14 | 2008-06-03 | Edwards Lifesciences Corporation | Mitral valve repair system and method for use |
JP4691017B2 (en) | 2003-03-18 | 2011-06-01 | セント ジュード メディカル インコーポレイテッド | Body tissue remodeling method and apparatus |
US20040220593A1 (en) | 2003-05-01 | 2004-11-04 | Secant Medical, Llc | Restraining clip for mitral valve repair |
US20040220657A1 (en) | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc., A Washington Corporation | Tissue shaping device with conformable anchors |
US20050004665A1 (en) | 2003-07-02 | 2005-01-06 | Lishan Aklog | Annuloplasty rings and methods for repairing cardiac valves |
US20060167474A1 (en) | 2003-09-15 | 2006-07-27 | Medtronic Vascular, Inc. | Apparatus and method for elongation of a papillary muscle |
WO2005027797A1 (en) | 2003-09-23 | 2005-03-31 | Ersin Erek | A mitral web apparatus for mitral valve insufficiencies |
WO2005069850A2 (en) | 2004-01-15 | 2005-08-04 | Macoviak John A | Trestle heart valve replacement |
US20050159810A1 (en) | 2004-01-15 | 2005-07-21 | Farzan Filsoufi | Devices and methods for repairing cardiac valves |
ITTO20040135A1 (en) | 2004-03-03 | 2004-06-03 | Sorin Biomedica Cardio Spa | CARDIAC VALVE PROSTHESIS |
US7641686B2 (en) | 2004-04-23 | 2010-01-05 | Direct Flow Medical, Inc. | Percutaneous heart valve with stentless support |
EP3398522B1 (en) | 2004-05-14 | 2019-12-25 | Evalve, Inc. | Locking mechanisms for fixation devices |
US7601117B2 (en) | 2004-06-30 | 2009-10-13 | Ethicon, Inc. | Systems and methods for assisting cardiac valve coaptation |
US7556632B2 (en) | 2004-07-09 | 2009-07-07 | Reza Zadno | Device and method for repairing tissue |
US7402134B2 (en) | 2004-07-15 | 2008-07-22 | Micardia Corporation | Magnetic devices and methods for reshaping heart anatomy |
JP2008513060A (en) * | 2004-09-14 | 2008-05-01 | エドワーズ ライフサイエンシーズ アーゲー | Device and method for treatment of heart valve regurgitation |
US7651502B2 (en) | 2004-09-24 | 2010-01-26 | Jackson Roger P | Spinal fixation tool set and method for rod reduction and fastener insertion |
US8052592B2 (en) | 2005-09-27 | 2011-11-08 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
EP1793745B2 (en) | 2004-09-27 | 2022-03-16 | Evalve, Inc. | Devices for tissue grasping and assessment |
US20060089711A1 (en) | 2004-10-27 | 2006-04-27 | Medtronic Vascular, Inc. | Multifilament anchor for reducing a compass of a lumen or structure in mammalian body |
WO2006086434A1 (en) | 2005-02-07 | 2006-08-17 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
WO2006105008A1 (en) | 2005-03-25 | 2006-10-05 | Ample Medical, Inc. | Device, systems, and methods for reshaping a heart valve annulus |
US20060241746A1 (en) | 2005-04-21 | 2006-10-26 | Emanuel Shaoulian | Magnetic implants and methods for reshaping tissue |
US7753934B2 (en) | 2005-04-22 | 2010-07-13 | Wilk Patent, Llc | Medical closure method and associated device |
EP1959865B1 (en) | 2005-12-15 | 2014-12-10 | The Cleveland Clinic Foundation | Apparatus for treating a regurgitant valve |
US20080039935A1 (en) | 2006-08-14 | 2008-02-14 | Wally Buch | Methods and apparatus for mitral valve repair |
US7533790B1 (en) | 2007-03-08 | 2009-05-19 | Cardica, Inc. | Surgical stapler |
-
2003
- 2003-05-19 US US10/441,753 patent/US20040044350A1/en not_active Abandoned
-
2004
- 2004-05-18 WO PCT/US2004/015741 patent/WO2004103434A2/en active Application Filing
- 2004-05-18 JP JP2006533226A patent/JP2007511248A/en active Pending
- 2004-05-18 EP EP19171888.1A patent/EP3539454B1/en active Active
- 2004-05-18 EP EP04752714.8A patent/EP1624792B1/en active Active
-
2009
- 2009-02-25 US US12/392,670 patent/US7682319B2/en not_active Expired - Fee Related
-
2010
- 2010-02-03 US US12/699,759 patent/US8123703B2/en not_active Expired - Lifetime
Patent Citations (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2108206A (en) * | 1937-03-09 | 1938-02-15 | Lillian Pearl Mecker | Tenaculum |
US3378010A (en) * | 1965-07-28 | 1968-04-16 | Coldling | Surgical clip with means for releasing the clamping pressure |
US3671979A (en) * | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US3874338A (en) * | 1972-10-09 | 1975-04-01 | Fritz Happel | Milking cup |
US4809695A (en) * | 1981-10-21 | 1989-03-07 | Owen M. Gwathmey | Suturing assembly and method |
US4917089A (en) * | 1988-08-29 | 1990-04-17 | Sideris Eleftherios B | Buttoned device for the transvenous occlusion of intracardiac defects |
US4994077A (en) * | 1989-04-21 | 1991-02-19 | Dobben Richard L | Artificial heart valve for implantation in a blood vessel |
US5209756A (en) * | 1989-11-03 | 1993-05-11 | Bahaa Botros Seedhom | Ligament fixation staple |
US5108368A (en) * | 1990-01-04 | 1992-04-28 | Pilot Cardiovascular System, Inc. | Steerable medical device |
US5195968A (en) * | 1990-02-02 | 1993-03-23 | Ingemar Lundquist | Catheter steering mechanism |
US6033378A (en) * | 1990-02-02 | 2000-03-07 | Ep Technologies, Inc. | Catheter steering mechanism |
US5411552A (en) * | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5226429A (en) * | 1991-06-20 | 1993-07-13 | Inamed Development Co. | Laparoscopic gastric band and method |
US5769812A (en) * | 1991-07-16 | 1998-06-23 | Heartport, Inc. | System for cardiac procedures |
US5522873A (en) * | 1991-12-26 | 1996-06-04 | Webster Laboratories, Inc. | Catheter having electrode with annular recess and method of using same |
US5423882A (en) * | 1991-12-26 | 1995-06-13 | Cordis-Webster, Inc. | Catheter having electrode with annular recess and method of using same |
US5417700A (en) * | 1992-03-30 | 1995-05-23 | Thomas D. Egan | Automatic suturing and ligating device |
US5318525A (en) * | 1992-04-10 | 1994-06-07 | Medtronic Cardiorhythm | Steerable electrode catheter |
US5713910A (en) * | 1992-09-04 | 1998-02-03 | Laurus Medical Corporation | Needle guidance system for endoscopic suture device |
US5312415A (en) * | 1992-09-22 | 1994-05-17 | Target Therapeutics, Inc. | Assembly for placement of embolic coils using frictional placement |
US5383886A (en) * | 1992-10-13 | 1995-01-24 | Kensey Nash Corporation | Methods and instruments for performing medical procedures percutaneously without a trocar |
US5718725A (en) * | 1992-12-03 | 1998-02-17 | Heartport, Inc. | Devices and methods for intracardiac procedures |
US5507725A (en) * | 1992-12-23 | 1996-04-16 | Angeion Corporation | Steerable catheter |
US5403326A (en) * | 1993-02-01 | 1995-04-04 | The Regents Of The University Of California | Method for performing a gastric wrap of the esophagus for use in the treatment of esophageal reflux |
US5855614A (en) * | 1993-02-22 | 1999-01-05 | Heartport, Inc. | Method and apparatus for thoracoscopic intracardiac procedures |
US5636634A (en) * | 1993-03-16 | 1997-06-10 | Ep Technologies, Inc. | Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes |
US5520701A (en) * | 1993-06-16 | 1996-05-28 | Lerch; Karl-Dieter | Set for the treatment of vascular deformations |
US5715817A (en) * | 1993-06-29 | 1998-02-10 | C.R. Bard, Inc. | Bidirectional steering catheter |
US5423858A (en) * | 1993-09-30 | 1995-06-13 | United States Surgical Corporation | Septoplasty fasteners and device for applying same |
US5741280A (en) * | 1994-01-18 | 1998-04-21 | Coral Medical | Knot tying method and apparatus |
US5618306A (en) * | 1994-02-14 | 1997-04-08 | Heartport, Inc. | Endoscopic microsurgical instruments and methods |
US5868733A (en) * | 1995-02-14 | 1999-02-09 | Daig Corporation | Guiding introducer system for use in the treatment of accessory pathways around the mitral valve using a retrograde approach |
US5640955A (en) * | 1995-02-14 | 1997-06-24 | Daig Corporation | Guiding introducers for use in the treatment of accessory pathways around the mitral valve using a retrograde approach |
US5772578A (en) * | 1995-09-14 | 1998-06-30 | Richard Wolf Gmbh | Endoscopic instrument |
US5634932A (en) * | 1995-10-10 | 1997-06-03 | Industrial & Scientific Designs, Ltd. | Cantilever aneurysm clip system |
US5716367A (en) * | 1995-10-18 | 1998-02-10 | Nissho Corporation | Catheter assembly for intracardiac suture |
US5719725A (en) * | 1995-11-30 | 1998-02-17 | Sanyo Electric Co., Ltd. | Disk playback device |
US5749828A (en) * | 1995-12-22 | 1998-05-12 | Hewlett-Packard Company | Bending neck for use with invasive medical devices |
US5879307A (en) * | 1996-03-15 | 1999-03-09 | Pulse Metric, Inc. | Non-invasive method and apparatus for diagnosing and monitoring aortic valve abnormalities, such a aortic regurgitation |
US6755777B2 (en) * | 1997-01-02 | 2004-06-29 | Myocor, Inc. | Heart wall tension reduction apparatus and method |
US6406420B1 (en) * | 1997-01-02 | 2002-06-18 | Myocor, Inc. | Methods and devices for improving cardiac function in hearts |
US5885271A (en) * | 1997-03-14 | 1999-03-23 | Millennium Cardiac Strategies, Inc. | Device for regional immobilization of a compliant body |
US20050004583A1 (en) * | 1997-06-27 | 2005-01-06 | Oz Mehmet C. | Method and apparatus for circulatory valve repair |
US20030105519A1 (en) * | 1997-09-04 | 2003-06-05 | Roland Fasol | Artificial chordae replacement |
US6019722A (en) * | 1997-09-17 | 2000-02-01 | Guidant Corporation | Device to permit offpump beating heart coronary bypass surgery |
US5916147A (en) * | 1997-09-22 | 1999-06-29 | Boury; Harb N. | Selectively manipulable catheter |
US6519291B1 (en) * | 1998-02-03 | 2003-02-11 | Lucent Technologies Inc. | Reduction of interference in discrete multi-tone (DMT) based communications systems |
US6562037B2 (en) * | 1998-02-12 | 2003-05-13 | Boris E. Paton | Bonding of soft biological tissues by passing high frequency electric current therethrough |
US6190408B1 (en) * | 1998-03-05 | 2001-02-20 | The University Of Cincinnati | Device and method for restructuring the heart chamber geometry |
US6556221B1 (en) * | 1998-07-01 | 2003-04-29 | Sony Corporation | Extended elements and mechanisms for displaying a rich graphical user interface in panel subunit |
US6746471B2 (en) * | 1998-07-29 | 2004-06-08 | Myocor, Inc. | Transventricular implant tools and devices |
US6077214A (en) * | 1998-07-29 | 2000-06-20 | Myocor, Inc. | Stress reduction apparatus and method |
US6709455B1 (en) * | 1998-08-14 | 2004-03-23 | Boston Scientific Scimed, Inc. | Stent-graft-membrane and method of making the same |
US6355030B1 (en) * | 1998-09-25 | 2002-03-12 | Cardiothoracic Systems, Inc. | Instruments and methods employing thermal energy for the repair and replacement of cardiac valves |
US6701929B2 (en) * | 1999-03-03 | 2004-03-09 | Hany Hussein | Device and method for treatment of congestive heart failure |
US20050021057A1 (en) * | 1999-04-09 | 2005-01-27 | Evalve, Inc. | Leaflet structuring |
US20050021056A1 (en) * | 1999-04-09 | 2005-01-27 | Evalve, Inc. | Leaflet structuring |
US20020013571A1 (en) * | 1999-04-09 | 2002-01-31 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US20040039442A1 (en) * | 1999-04-09 | 2004-02-26 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20040030382A1 (en) * | 1999-04-09 | 2004-02-12 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20050033446A1 (en) * | 1999-04-09 | 2005-02-10 | Evalve, Inc. A California Corporation | Methods and apparatus for cardiac valve repair |
US20040003819A1 (en) * | 1999-04-09 | 2004-01-08 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20020035361A1 (en) * | 1999-06-25 | 2002-03-21 | Houser Russell A. | Apparatus and methods for treating tissue |
US6210432B1 (en) * | 1999-06-29 | 2001-04-03 | Jan Otto Solem | Device and method for treatment of mitral insufficiency |
US20030069636A1 (en) * | 1999-06-30 | 2003-04-10 | Solem Jan Otto | Method for treatment of mitral insufficiency |
US20040039443A1 (en) * | 1999-06-30 | 2004-02-26 | Solem Jan Otto | Method and device for treatment of mitral insufficiency |
US20030069570A1 (en) * | 1999-10-02 | 2003-04-10 | Witzel Thomas H. | Methods for repairing mitral valve annulus percutaneously |
US6875224B2 (en) * | 1999-10-13 | 2005-04-05 | Massachusetts General Hospital | Devices and methods for percutaneous mitral valve repair |
US6537314B2 (en) * | 2000-01-31 | 2003-03-25 | Ev3 Santa Rosa, Inc. | Percutaneous mitral annuloplasty and cardiac reinforcement |
US6402781B1 (en) * | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US20040088047A1 (en) * | 2000-02-02 | 2004-05-06 | Paul A. Spence | Heart valve repair apparatus and methods |
US20040024414A1 (en) * | 2000-06-20 | 2004-02-05 | Downing Stephen W. | Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures inside of a beating heart |
US6702826B2 (en) * | 2000-06-23 | 2004-03-09 | Viacor, Inc. | Automated annular plication for mitral valve repair |
US6709362B2 (en) * | 2000-09-05 | 2004-03-23 | Toyota Jidosha Kabushiki Kaisha | Electric oil pump control device |
US20050055089A1 (en) * | 2000-09-20 | 2005-03-10 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus |
US6723038B1 (en) * | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US20030074012A1 (en) * | 2000-10-10 | 2003-04-17 | Coalescent Surgical, Inc. | Minimally invasive annuloplasty procedure and apparatus |
US20020077687A1 (en) * | 2000-12-14 | 2002-06-20 | Ahn Samuel S. | Catheter assembly for treating ischemic tissue |
US20040019378A1 (en) * | 2001-04-24 | 2004-01-29 | Hlavka Edwin J. | Method and apparatus for performing catheter-based annuloplasty |
US20030078654A1 (en) * | 2001-08-14 | 2003-04-24 | Taylor Daniel C. | Method and apparatus for improving mitral valve function |
US6726716B2 (en) * | 2001-08-24 | 2004-04-27 | Edwards Lifesciences Corporation | Self-molding annuloplasty ring |
US20030063742A1 (en) * | 2001-09-28 | 2003-04-03 | Neufeld E. David | Method and apparatus for generating a strong random number for use in a security subsystem for a processor-based device |
US20030069595A1 (en) * | 2001-10-05 | 2003-04-10 | Phung Trinh D. | Surgical punch device |
US20050049698A1 (en) * | 2001-11-13 | 2005-03-03 | Bolling Steven F. | Methods of implanting a mitral valve annuloplasty ring to correct mitral regurgitation |
US6575971B2 (en) * | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US6754510B2 (en) * | 2001-12-13 | 2004-06-22 | Superconductor Technologies, Inc. | MEMS-based bypass system for use with a HTS RF receiver |
US6740107B2 (en) * | 2001-12-19 | 2004-05-25 | Trimedyne, Inc. | Device for treatment of atrioventricular valve regurgitation |
US20030120341A1 (en) * | 2001-12-21 | 2003-06-26 | Hani Shennib | Devices and methods of repairing cardiac valves |
US20040019377A1 (en) * | 2002-01-14 | 2004-01-29 | Taylor Daniel C. | Method and apparatus for reducing mitral regurgitation |
US20040073302A1 (en) * | 2002-02-05 | 2004-04-15 | Jonathan Rourke | Method and apparatus for improving mitral valve function |
US20040049211A1 (en) * | 2002-06-12 | 2004-03-11 | Mitral Interventions, Inc. | Method and apparatus for tissue connection |
US20040106989A1 (en) * | 2002-07-03 | 2004-06-03 | Wilson Robert F. | Leaflet reinforcement for regurgitant valves |
US20040122448A1 (en) * | 2002-08-13 | 2004-06-24 | The General Hospital Corporation | Cardiac devices and methods for percutaneous repair of atrioventricular valves |
US20050059351A1 (en) * | 2002-08-30 | 2005-03-17 | Patrick Cauwels | User-specified outputs in mobile wireless communication devices and methods therefor |
US20040111098A1 (en) * | 2002-09-02 | 2004-06-10 | Hallen Jan Ake | Obstetric vacuum extractor |
US20040097979A1 (en) * | 2002-11-14 | 2004-05-20 | Oleg Svanidze | Aortic valve implantation device |
US20050004668A1 (en) * | 2003-07-02 | 2005-01-06 | Flexcor, Inc. | Annuloplasty rings and methods for repairing cardiac valves |
US20050038508A1 (en) * | 2003-08-13 | 2005-02-17 | Shlomo Gabbay | Implantable cardiac prosthesis for mitigating prolapse of a heart valve |
Cited By (889)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040002719A1 (en) * | 1997-06-27 | 2004-01-01 | Oz Mehmet C. | Method and apparatus for circulatory valve repair |
US7758596B2 (en) | 1997-06-27 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for circulatory valve repair |
US20040199183A1 (en) * | 1997-06-27 | 2004-10-07 | Oz Mehmet C. | Method and apparatus for circulatory valve repair |
US7682369B2 (en) | 1997-09-12 | 2010-03-23 | Evalve, Inc. | Surgical device for connecting soft tissue |
US7981123B2 (en) | 1997-09-12 | 2011-07-19 | Evalve, Inc. | Surgical device for connecting soft tissue |
US8740918B2 (en) | 1997-09-12 | 2014-06-03 | Evalve, Inc. | Surgical device for connecting soft tissue |
US20110238165A1 (en) * | 1997-09-12 | 2011-09-29 | Evalve, Inc. | Surgical device for connecting soft tissue |
US9510837B2 (en) | 1997-09-12 | 2016-12-06 | Evalve, Inc. | Surgical device for connecting soft tissue |
US20100191256A1 (en) * | 1997-09-12 | 2010-07-29 | Evalve, Inc. | Surgical device for connecting soft tissue |
US8343174B2 (en) | 1999-04-09 | 2013-01-01 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
US20040030382A1 (en) * | 1999-04-09 | 2004-02-12 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
WO2004103162A2 (en) | 1999-04-09 | 2004-12-02 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20050021057A1 (en) * | 1999-04-09 | 2005-01-27 | Evalve, Inc. | Leaflet structuring |
US20050021056A1 (en) * | 1999-04-09 | 2005-01-27 | Evalve, Inc. | Leaflet structuring |
US7704269B2 (en) | 1999-04-09 | 2010-04-27 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20100100108A1 (en) * | 1999-04-09 | 2010-04-22 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US7682319B2 (en) | 1999-04-09 | 2010-03-23 | Evalve, Inc. | Steerable access sheath and methods of use |
US7736388B2 (en) | 1999-04-09 | 2010-06-15 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20100217283A1 (en) * | 1999-04-09 | 2010-08-26 | Evalve,Inc. | Leaflet suturing |
US7666204B2 (en) | 1999-04-09 | 2010-02-23 | Evalve, Inc. | Multi-catheter steerable guiding system and methods of use |
US7655015B2 (en) | 1999-04-09 | 2010-02-02 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US8500761B2 (en) | 1999-04-09 | 2013-08-06 | Abbott Vascular | Fixation devices, systems and methods for engaging tissue |
US8029518B2 (en) | 1999-04-09 | 2011-10-04 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US20100016958A1 (en) * | 1999-04-09 | 2010-01-21 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20090326567A1 (en) * | 1999-04-09 | 2009-12-31 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
US9510829B2 (en) | 1999-04-09 | 2016-12-06 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US7811296B2 (en) | 1999-04-09 | 2010-10-12 | Evalve, Inc. | Fixation devices for variation in engagement of tissue |
US7753923B2 (en) | 1999-04-09 | 2010-07-13 | Evalve, Inc. | Leaflet suturing |
US20090198322A1 (en) * | 1999-04-09 | 2009-08-06 | Deem Mark E | Methods And Apparatus For Cardiac Valve Repair |
US8409273B2 (en) | 1999-04-09 | 2013-04-02 | Abbott Vascular Inc | Multi-catheter steerable guiding system and methods of use |
US20090156995A1 (en) * | 1999-04-09 | 2009-06-18 | Evalve, Inc. | Steerable access sheath and methods of use |
US7998151B2 (en) | 1999-04-09 | 2011-08-16 | Evalve, Inc. | Leaflet suturing |
US20040039442A1 (en) * | 1999-04-09 | 2004-02-26 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US8323334B2 (en) | 1999-04-09 | 2012-12-04 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US8057493B2 (en) | 1999-04-09 | 2011-11-15 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US8734505B2 (en) | 1999-04-09 | 2014-05-27 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US9044246B2 (en) | 1999-04-09 | 2015-06-02 | Abbott Vascular Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US8740920B2 (en) | 1999-04-09 | 2014-06-03 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US8123703B2 (en) | 1999-04-09 | 2012-02-28 | Evalve, Inc. | Steerable access sheath and methods of use |
US20070038293A1 (en) * | 1999-04-09 | 2007-02-15 | St Goar Frederick G | Device and methods for endoscopic annuloplasty |
US8216256B2 (en) | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
US10327743B2 (en) | 1999-04-09 | 2019-06-25 | Evalve, Inc. | Device and methods for endoscopic annuloplasty |
US20080051807A1 (en) * | 1999-04-09 | 2008-02-28 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20080051703A1 (en) * | 1999-04-09 | 2008-02-28 | Evalve, Inc. | Multi-catheter steerable guiding system and methods of use |
US20080183194A1 (en) * | 1999-04-09 | 2008-07-31 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US8187299B2 (en) | 1999-04-09 | 2012-05-29 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20070118155A1 (en) * | 1999-04-09 | 2007-05-24 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20080167714A1 (en) * | 1999-04-09 | 2008-07-10 | Evalve, Inc. | Methods and apparatus for cardiac valve repair |
US20070129737A1 (en) * | 1999-04-09 | 2007-06-07 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20080097489A1 (en) * | 1999-04-09 | 2008-04-24 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20030201519A1 (en) * | 1999-12-29 | 2003-10-30 | Lamson Michael A. | Semiconductor package with conductor impedance selected during assembly |
US8956388B2 (en) | 2000-01-05 | 2015-02-17 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant |
US8758400B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US8758396B2 (en) | 2000-01-05 | 2014-06-24 | Integrated Vascular Systems, Inc. | Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use |
US9579091B2 (en) | 2000-01-05 | 2017-02-28 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US10111664B2 (en) | 2000-01-05 | 2018-10-30 | Integrated Vascular Systems, Inc. | Closure system and methods of use |
US9050087B2 (en) | 2000-01-05 | 2015-06-09 | Integrated Vascular Systems, Inc. | Integrated vascular device with puncture site closure component and sealant and methods of use |
US8784447B2 (en) | 2000-09-08 | 2014-07-22 | Abbott Vascular Inc. | Surgical stapler |
US9060769B2 (en) | 2000-09-08 | 2015-06-23 | Abbott Vascular Inc. | Surgical stapler |
US9402625B2 (en) | 2000-09-08 | 2016-08-02 | Abbott Vascular Inc. | Surgical stapler |
US9089674B2 (en) | 2000-10-06 | 2015-07-28 | Integrated Vascular Systems, Inc. | Apparatus and methods for positioning a vascular sheath |
US7776053B2 (en) * | 2000-10-26 | 2010-08-17 | Boston Scientific Scimed, Inc. | Implantable valve system |
US20040059411A1 (en) * | 2000-10-26 | 2004-03-25 | Strecker Ernst Peter | Implantable valve system |
US20070118209A1 (en) * | 2000-10-26 | 2007-05-24 | Strecker Ernst P | Implantable valve system |
US8690910B2 (en) | 2000-12-07 | 2014-04-08 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8597325B2 (en) | 2000-12-07 | 2013-12-03 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US9554786B2 (en) | 2000-12-07 | 2017-01-31 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8486108B2 (en) | 2000-12-07 | 2013-07-16 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US10245013B2 (en) | 2000-12-07 | 2019-04-02 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8603136B2 (en) | 2000-12-07 | 2013-12-10 | Integrated Vascular Systems, Inc. | Apparatus and methods for providing tactile feedback while delivering a closure device |
US9320522B2 (en) | 2000-12-07 | 2016-04-26 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US9585646B2 (en) | 2000-12-07 | 2017-03-07 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8486092B2 (en) | 2000-12-07 | 2013-07-16 | Integrated Vascular Systems, Inc. | Closure device and methods for making and using them |
US8728119B2 (en) | 2001-06-07 | 2014-05-20 | Abbott Vascular Inc. | Surgical staple |
US10624618B2 (en) | 2001-06-27 | 2020-04-21 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US10653427B2 (en) | 2001-06-27 | 2020-05-19 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US20090270858A1 (en) * | 2001-11-15 | 2009-10-29 | Evalve, Inc. | Cardiac valve leaflet attachment device and methods thereof |
US20110178596A1 (en) * | 2001-11-15 | 2011-07-21 | Abbott Vascular Inc. | Cardiac valve leaflet attachement device and methods thereof |
US20050149014A1 (en) * | 2001-11-15 | 2005-07-07 | Quantumcor, Inc. | Cardiac valve leaflet attachment device and methods thereof |
US7938827B2 (en) | 2001-11-15 | 2011-05-10 | Evalva, Inc. | Cardiac valve leaflet attachment device and methods thereof |
US8216230B2 (en) | 2001-11-15 | 2012-07-10 | Evalve, Inc. | Cardiac valve leaflet attachment device and methods thereof |
US9498196B2 (en) | 2002-02-21 | 2016-11-22 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US8579932B2 (en) | 2002-02-21 | 2013-11-12 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US10201340B2 (en) | 2002-02-21 | 2019-02-12 | Integrated Vascular Systems, Inc. | Sheath apparatus and methods for delivering a closure device |
US20030191479A1 (en) * | 2002-04-03 | 2003-10-09 | Thornton Sally C. | Body lumen closure |
US20060085066A1 (en) * | 2002-04-03 | 2006-04-20 | Boston Scientific Corporation | Body lumen closure |
US20040230297A1 (en) * | 2002-04-03 | 2004-11-18 | Boston Scientific Corporation | Artificial valve |
US7682385B2 (en) | 2002-04-03 | 2010-03-23 | Boston Scientific Corporation | Artificial valve |
US8469995B2 (en) | 2002-06-04 | 2013-06-25 | Abbott Vascular Inc. | Blood vessel closure clip and delivery device |
US9295469B2 (en) | 2002-06-04 | 2016-03-29 | Abbott Vascular Inc. | Blood vessel closure clip and delivery device |
US9980728B2 (en) | 2002-06-04 | 2018-05-29 | Abbott Vascular Inc | Blood vessel closure clip and delivery device |
US9763658B2 (en) | 2002-08-02 | 2017-09-19 | Cedars-Sinai Medical Center | Methods and apparatus for atrioventricular valve repair |
US10499905B2 (en) | 2002-08-02 | 2019-12-10 | Cedars-Sinai Medical Center | Methods and apparatus for atrioventricular valve repair |
US20060030885A1 (en) * | 2002-10-15 | 2006-02-09 | Hyde Gregory M | Apparatuses and methods for heart valve repair |
US20100222876A1 (en) * | 2002-10-15 | 2010-09-02 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
US8133272B2 (en) | 2002-10-15 | 2012-03-13 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
US20070050019A1 (en) * | 2002-10-15 | 2007-03-01 | Hyde Gregory M | Apparatuses and methods for heart valve repair |
US7740638B2 (en) | 2002-10-15 | 2010-06-22 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
US20040215339A1 (en) * | 2002-10-24 | 2004-10-28 | Drasler William J. | Venous valve apparatus and method |
US20080125861A1 (en) * | 2002-11-15 | 2008-05-29 | Webler William E | Valve aptation assist device |
US20070123978A1 (en) * | 2002-11-15 | 2007-05-31 | Cox Daniel L | Apparatuses and methods for heart valve repair |
US7828819B2 (en) | 2002-11-15 | 2010-11-09 | Advanced Cardiovascular Systems, Inc. | Cord locking mechanism for use in small systems |
US20040133274A1 (en) * | 2002-11-15 | 2004-07-08 | Webler William E. | Cord locking mechanism for use in small systems |
US8070804B2 (en) | 2002-11-15 | 2011-12-06 | Abbott Cardiovascular Systems Inc. | Apparatus and methods for heart valve repair |
US20110184512A1 (en) * | 2002-11-15 | 2011-07-28 | Webler William E | Valve aptation assist device |
US7914577B2 (en) | 2002-11-15 | 2011-03-29 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
US7927370B2 (en) | 2002-11-15 | 2011-04-19 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
US7942928B2 (en) | 2002-11-15 | 2011-05-17 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
US20050038506A1 (en) * | 2002-11-15 | 2005-02-17 | Webler William E. | Apparatuses and methods for heart valve repair |
US8187324B2 (en) | 2002-11-15 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Telescoping apparatus for delivering and adjusting a medical device in a vessel |
US8579967B2 (en) | 2002-11-15 | 2013-11-12 | Advanced Cardiovascular Systems, Inc. | Valve aptation assist device |
US20050209580A1 (en) * | 2002-12-30 | 2005-09-22 | Scimed Life Systems, Inc. | Valve treatment catheter and methods |
US20040127848A1 (en) * | 2002-12-30 | 2004-07-01 | Toby Freyman | Valve treatment catheter and methods |
US7780627B2 (en) | 2002-12-30 | 2010-08-24 | Boston Scientific Scimed, Inc. | Valve treatment catheter and methods |
US8585836B2 (en) | 2002-12-31 | 2013-11-19 | Integrated Vascular Systems, Inc. | Methods for manufacturing a clip and clip |
US20110224666A1 (en) * | 2003-01-21 | 2011-09-15 | Gareth Davies | Method of surgical perforation via the delivery of energy |
US9597146B2 (en) * | 2003-01-21 | 2017-03-21 | Baylis Medical Company Inc. | Method of surgical perforation via the delivery of energy |
US10398418B2 (en) | 2003-01-30 | 2019-09-03 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US9271707B2 (en) | 2003-01-30 | 2016-03-01 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US8926656B2 (en) | 2003-01-30 | 2015-01-06 | Integated Vascular Systems, Inc. | Clip applier and methods of use |
US11589856B2 (en) | 2003-01-30 | 2023-02-28 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US9398914B2 (en) | 2003-01-30 | 2016-07-26 | Integrated Vascular Systems, Inc. | Methods of use of a clip applier |
US8529587B2 (en) | 2003-01-30 | 2013-09-10 | Integrated Vascular Systems, Inc. | Methods of use of a clip applier |
US8398656B2 (en) | 2003-01-30 | 2013-03-19 | Integrated Vascular Systems, Inc. | Clip applier and methods of use |
US10646229B2 (en) | 2003-05-19 | 2020-05-12 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US10828042B2 (en) | 2003-05-19 | 2020-11-10 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US10631871B2 (en) | 2003-05-19 | 2020-04-28 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US10667823B2 (en) | 2003-05-19 | 2020-06-02 | Evalve, Inc. | Fixation devices, systems and methods for engaging tissue |
US8016784B1 (en) | 2003-09-30 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Deflectable catheter assembly having compression compensation mechanism |
US7998112B2 (en) | 2003-09-30 | 2011-08-16 | Abbott Cardiovascular Systems Inc. | Deflectable catheter assembly and method of making same |
US20050137681A1 (en) * | 2003-12-19 | 2005-06-23 | Scimed Life Systems, Inc. | Venous valve apparatus, system, and method |
US20050137676A1 (en) * | 2003-12-19 | 2005-06-23 | Scimed Life Systems, Inc. | Venous valve apparatus, system, and method |
US10869764B2 (en) | 2003-12-19 | 2020-12-22 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US8721717B2 (en) | 2003-12-19 | 2014-05-13 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7854761B2 (en) | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US9301843B2 (en) | 2003-12-19 | 2016-04-05 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US20050149096A1 (en) * | 2003-12-23 | 2005-07-07 | Hilal Said S. | Catheter with conduit traversing tip |
US20050251189A1 (en) * | 2004-05-07 | 2005-11-10 | Usgi Medical Inc. | Multi-position tissue manipulation assembly |
US20070027455A1 (en) * | 2004-05-12 | 2007-02-01 | Modesitt D B | Access and closure device and method |
US20070032804A1 (en) * | 2004-05-12 | 2007-02-08 | Modesitt D B | Access and closure device and method |
US20070032802A1 (en) * | 2004-05-12 | 2007-02-08 | Modesitt D B | Access and closure device and method |
US8002793B2 (en) | 2004-05-12 | 2011-08-23 | Arstasis, Inc. | Access and closure device and method |
US8002791B2 (en) | 2004-05-12 | 2011-08-23 | Arstasis, Inc. | Access and closure device and method |
US20050267520A1 (en) * | 2004-05-12 | 2005-12-01 | Modesitt D B | Access and closure device and method |
US7998169B2 (en) | 2004-05-12 | 2011-08-16 | Arstasis, Inc. | Access and closure device and method |
US20070027454A1 (en) * | 2004-05-12 | 2007-02-01 | Modesitt D B | Access and closure device and method |
US8012168B2 (en) | 2004-05-12 | 2011-09-06 | Arstasis, Inc. | Access and closure device and method |
US8002792B2 (en) | 2004-05-12 | 2011-08-23 | Arstasis, Inc. | Access and closure device and method |
US20070032803A1 (en) * | 2004-05-12 | 2007-02-08 | Modesitt D B | Access and closure device and method |
WO2005112792A2 (en) | 2004-05-14 | 2005-12-01 | Evalve, Inc. | Locking mechanisms for fixation devices and methods of engaging tissue |
US8590760B2 (en) | 2004-05-25 | 2013-11-26 | Abbott Vascular Inc. | Surgical stapler |
US7678133B2 (en) | 2004-07-10 | 2010-03-16 | Arstasis, Inc. | Biological tissue closure device and method |
US20060036267A1 (en) * | 2004-08-11 | 2006-02-16 | Usgi Medical Inc. | Methods and apparatus for performing malabsorptive bypass procedures within a patient's gastro-intestinal lumen |
US8932349B2 (en) | 2004-09-02 | 2015-01-13 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
US20060047338A1 (en) * | 2004-09-02 | 2006-03-02 | Scimed Life Systems, Inc. | Cardiac valve, system, and method |
US8002824B2 (en) | 2004-09-02 | 2011-08-23 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
US9918834B2 (en) | 2004-09-02 | 2018-03-20 | Boston Scientific Scimed, Inc. | Cardiac valve, system and method |
US10159527B2 (en) | 2004-09-24 | 2018-12-25 | Syntheon, Llc | Selective stiffening catheter and methods for operating a selective stiffening catheter |
US11376065B2 (en) | 2004-09-24 | 2022-07-05 | Syn Variflex, Llc | Selective stiffening catheter |
US10463427B2 (en) | 2004-09-24 | 2019-11-05 | Syn Variflex, Llc | Selective stiffening catheter |
US11382690B2 (en) | 2004-09-24 | 2022-07-12 | Syn Variflex, Llc | Selective stiffening catheter |
US11304715B2 (en) | 2004-09-27 | 2022-04-19 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US20070197858A1 (en) * | 2004-09-27 | 2007-08-23 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US11484331B2 (en) | 2004-09-27 | 2022-11-01 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US20060229659A1 (en) * | 2004-12-09 | 2006-10-12 | The Foundry, Inc. | Aortic valve repair |
WO2006063199A2 (en) | 2004-12-09 | 2006-06-15 | The Foundry, Inc. | Aortic valve repair |
US10350004B2 (en) | 2004-12-09 | 2019-07-16 | Twelve, Inc. | Intravascular treatment catheters |
US7803168B2 (en) | 2004-12-09 | 2010-09-28 | The Foundry, Llc | Aortic valve repair |
US11272982B2 (en) | 2004-12-09 | 2022-03-15 | Twelve, Inc. | Intravascular treatment catheters |
US9414852B2 (en) | 2004-12-09 | 2016-08-16 | Twelve, Inc. | Aortic valve repair |
US20100324554A1 (en) * | 2004-12-09 | 2010-12-23 | The Foundry, Llc | Aortic Valve Repair |
US7981152B1 (en) | 2004-12-10 | 2011-07-19 | Advanced Cardiovascular Systems, Inc. | Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites |
US9017284B2 (en) * | 2004-12-17 | 2015-04-28 | Biocardia, Inc. | Method of implanting a PFO occluder in a patient |
US20130331932A1 (en) * | 2004-12-17 | 2013-12-12 | Biocardia, Inc. | Method of Accessing a Carotid Artery of a Patient |
US9011373B2 (en) * | 2004-12-17 | 2015-04-21 | Biocardia, Inc. | Method of accessing a carotid artery of a patient |
US20130331819A1 (en) * | 2004-12-17 | 2013-12-12 | Biocardia, Inc. | Method of Accessing a Contralateral Femoral Artery of a Patient |
US9078994B2 (en) * | 2004-12-17 | 2015-07-14 | Biocardia, Inc. | Method of accessing a contralateral femoral artery of a patient |
US9022977B2 (en) * | 2004-12-17 | 2015-05-05 | Biocardia, Inc. | Method of accessing a renal artery of a patient |
US20130331881A1 (en) * | 2004-12-17 | 2013-12-12 | Biocardia, Inc. | Method of Implanting a PFO Occluder in a Patient |
US20130274714A1 (en) * | 2004-12-17 | 2013-10-17 | Biocardia, Inc. | Method Of Accessing A Renal Artery Of A Patient |
US10492906B2 (en) | 2005-01-20 | 2019-12-03 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US9788945B2 (en) | 2005-01-20 | 2017-10-17 | Jenavalve Technology, Inc. | Systems for implanting an endoprosthesis |
EP2351541B1 (en) | 2005-01-20 | 2017-06-07 | JenaValve Technology, Inc. | Catheter for transvascular implantation of heart valve prosthetics |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US20090234443A1 (en) * | 2005-01-20 | 2009-09-17 | Ottma Ruediger | Catheter for the Transvascular Implantation of Prosthetic Heart Valves |
US9775705B2 (en) | 2005-01-20 | 2017-10-03 | Jenavalve Technology, Inc. | Methods of implanting an endoprosthesis |
US8679174B2 (en) * | 2005-01-20 | 2014-03-25 | JenaValve Technology, GmbH | Catheter for the transvascular implantation of prosthetic heart valves |
US9364213B2 (en) | 2005-01-21 | 2016-06-14 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method |
US9700300B2 (en) | 2005-01-21 | 2017-07-11 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair apparatus |
US8465500B2 (en) | 2005-01-21 | 2013-06-18 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method and apparatus |
US11534156B2 (en) | 2005-01-21 | 2022-12-27 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method and apparatus |
US20100174297A1 (en) * | 2005-01-21 | 2010-07-08 | Giovanni Speziali | Thorascopic Heart Valve Repair Method and Apparatus |
US10582924B2 (en) | 2005-01-21 | 2020-03-10 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method |
US8968338B2 (en) | 2005-01-21 | 2015-03-03 | Mayo Foundation For Medical Education And Research | Thorascopic heart valve repair method and apparatus |
US7854755B2 (en) | 2005-02-01 | 2010-12-21 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
US9622859B2 (en) | 2005-02-01 | 2017-04-18 | Boston Scientific Scimed, Inc. | Filter system and method |
US20060173475A1 (en) * | 2005-02-01 | 2006-08-03 | Boston Scientific Scimed, Inc. | Vascular catheter, system, and method |
US9332893B2 (en) | 2005-02-02 | 2016-05-10 | Intuitive Surgical Operations, Inc. | Delivery of biological compounds to ischemic and/or infarcted tissue |
US9526401B2 (en) | 2005-02-02 | 2016-12-27 | Intuitive Surgical Operations, Inc. | Flow reduction hood systems |
US10278588B2 (en) | 2005-02-02 | 2019-05-07 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US10064540B2 (en) | 2005-02-02 | 2018-09-04 | Intuitive Surgical Operations, Inc. | Visualization apparatus for transseptal access |
US11406250B2 (en) | 2005-02-02 | 2022-08-09 | Intuitive Surgical Operations, Inc. | Methods and apparatus for treatment of atrial fibrillation |
US11478152B2 (en) | 2005-02-02 | 2022-10-25 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US11819190B2 (en) | 2005-02-02 | 2023-11-21 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US10772492B2 (en) | 2005-02-02 | 2020-09-15 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US11889982B2 (en) | 2005-02-02 | 2024-02-06 | Intuitive Surgical Operations, Inc. | Electrophysiology mapping and visualization system |
US10368729B2 (en) | 2005-02-02 | 2019-08-06 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US10463237B2 (en) | 2005-02-02 | 2019-11-05 | Intuitive Surgical Operations, Inc. | Delivery of biological compounds to ischemic and/or infarcted tissue |
US20060178550A1 (en) * | 2005-02-04 | 2006-08-10 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US7878966B2 (en) | 2005-02-04 | 2011-02-01 | Boston Scientific Scimed, Inc. | Ventricular assist and support device |
US20060229708A1 (en) * | 2005-02-07 | 2006-10-12 | Powell Ferolyn T | Methods, systems and devices for cardiac valve repair |
US7780722B2 (en) | 2005-02-07 | 2010-08-24 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
WO2011034973A2 (en) | 2005-02-07 | 2011-03-24 | Abbott Vascular | Methods, systems and devices for cardiac valve repair |
US10667911B2 (en) | 2005-02-07 | 2020-06-02 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US20110066233A1 (en) * | 2005-02-07 | 2011-03-17 | Thornton Troy L | Methods, systems and devices for cardiac valve repair |
WO2011034628A1 (en) | 2005-02-07 | 2011-03-24 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US8470028B2 (en) | 2005-02-07 | 2013-06-25 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
US20060178729A1 (en) * | 2005-02-07 | 2006-08-10 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7670368B2 (en) | 2005-02-07 | 2010-03-02 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US9808341B2 (en) | 2005-02-23 | 2017-11-07 | Boston Scientific Scimed Inc. | Valve apparatus, system and method |
US9370419B2 (en) | 2005-02-23 | 2016-06-21 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US7867274B2 (en) | 2005-02-23 | 2011-01-11 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US11497605B2 (en) | 2005-03-17 | 2022-11-15 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US9861473B2 (en) | 2005-04-15 | 2018-01-09 | Boston Scientific Scimed Inc. | Valve apparatus, system and method |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US8512399B2 (en) | 2005-04-15 | 2013-08-20 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
US9950144B2 (en) | 2005-04-22 | 2018-04-24 | Advanced Cardiovascular Systems, Inc. | Dual needle delivery system |
US9149602B2 (en) | 2005-04-22 | 2015-10-06 | Advanced Cardiovascular Systems, Inc. | Dual needle delivery system |
US20070106246A1 (en) * | 2005-05-12 | 2007-05-10 | Modesitt D B | Access and closure device and method |
US8002794B2 (en) | 2005-05-12 | 2011-08-23 | Arstasis, Inc. | Access and closure device and method |
US8083767B2 (en) | 2005-05-12 | 2011-12-27 | Arstasis, Inc. | Access and closure device and method |
US20070255313A1 (en) * | 2005-05-12 | 2007-11-01 | Arstasis, Inc. | Access and closure device and method |
US20060271078A1 (en) * | 2005-05-12 | 2006-11-30 | Modesitt D B | Access and closure device and method |
US8241325B2 (en) | 2005-05-12 | 2012-08-14 | Arstasis, Inc. | Access and closure device and method |
US11090036B2 (en) | 2005-05-20 | 2021-08-17 | Neotract, Inc. | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US11471148B2 (en) | 2005-05-20 | 2022-10-18 | Teleflex Life Sciences Limited | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US10945719B2 (en) | 2005-05-20 | 2021-03-16 | Neotract, Inc. | Devices, systems and methods for retracting, lifting, compressing, supporting or repositioning tissues or anatomical structures |
US11504149B2 (en) | 2005-05-20 | 2022-11-22 | Teleflex Life Sciences Limited | Median lobe destruction apparatus and method |
US9028542B2 (en) | 2005-06-10 | 2015-05-12 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US8012198B2 (en) | 2005-06-10 | 2011-09-06 | Boston Scientific Scimed, Inc. | Venous valve, system, and method |
US11337812B2 (en) | 2005-06-10 | 2022-05-24 | Boston Scientific Scimed, Inc. | Venous valve, system and method |
US20070049908A1 (en) * | 2005-06-15 | 2007-03-01 | Jan Boese | Apparatus for automatic replacement of instruments during minimally invasive procedures |
US8353851B2 (en) * | 2005-06-15 | 2013-01-15 | Siemens Aktiengesellschaft | Apparatus for automatic replacement of instruments during minimally invasive procedures |
US8926633B2 (en) | 2005-06-24 | 2015-01-06 | Abbott Laboratories | Apparatus and method for delivering a closure element |
US8518057B2 (en) | 2005-07-01 | 2013-08-27 | Abbott Laboratories | Clip applier and methods of use |
US11344304B2 (en) | 2005-07-01 | 2022-05-31 | Abbott Laboratories | Clip applier and methods of use |
US9050068B2 (en) | 2005-07-01 | 2015-06-09 | Abbott Laboratories | Clip applier and methods of use |
US10085753B2 (en) | 2005-07-01 | 2018-10-02 | Abbott Laboratories | Clip applier and methods of use |
US20120245418A1 (en) * | 2005-08-30 | 2012-09-27 | Boston Scientific Scimed, Inc. | Method for forming an endoscope articulation joint |
US20220053996A1 (en) * | 2005-08-30 | 2022-02-24 | Boston Scientific Scimed, Inc. | Method for forming an endoscope articulation joint |
US11957312B2 (en) * | 2005-08-30 | 2024-04-16 | Boston Scientific Scimed, Inc. | Method for forming an endoscope articulation joint |
US9439557B2 (en) * | 2005-08-30 | 2016-09-13 | Boston Scientific Scimed, Inc. | Articulation joint |
US11191424B2 (en) | 2005-08-30 | 2021-12-07 | Boston Scientific Scimed, Inc. | Method for forming an endoscope articulation joint |
US10052013B2 (en) | 2005-08-30 | 2018-08-21 | Boston Scientific Scimed, Inc. | Medical device comprising segments |
US9474609B2 (en) | 2005-09-21 | 2016-10-25 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US8460365B2 (en) | 2005-09-21 | 2013-06-11 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US10548734B2 (en) | 2005-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US20070067021A1 (en) * | 2005-09-21 | 2007-03-22 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US7951189B2 (en) | 2005-09-21 | 2011-05-31 | Boston Scientific Scimed, Inc. | Venous valve, system, and method with sinus pocket |
US8672997B2 (en) | 2005-09-21 | 2014-03-18 | Boston Scientific Scimed, Inc. | Valve with sinus |
US8052592B2 (en) | 2005-09-27 | 2011-11-08 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US20100022823A1 (en) * | 2005-09-27 | 2010-01-28 | Evalve, Inc. | Methods and devices for tissue grasping and assessment |
US9510732B2 (en) | 2005-10-25 | 2016-12-06 | Intuitive Surgical Operations, Inc. | Methods and apparatus for efficient purging |
US10363134B2 (en) | 2005-10-28 | 2019-07-30 | Jenavalve Technology, Inc. | Device for the implantation and fixation of prosthetic valves |
US11116628B2 (en) | 2005-10-28 | 2021-09-14 | Jenavalve Technology, Inc. | Device for the implantation and fixation of prosthetic valves |
US20070112361A1 (en) * | 2005-11-07 | 2007-05-17 | Schonholz Steven M | Surgical repair systems and methods of using the same |
US7803130B2 (en) | 2006-01-09 | 2010-09-28 | Vance Products Inc. | Deflectable tip access sheath |
US20070167065A1 (en) * | 2006-01-13 | 2007-07-19 | Cook Incorporated | Wire guide having distal coupling tip |
US7811238B2 (en) * | 2006-01-13 | 2010-10-12 | Cook Incorporated | Wire guide having distal coupling tip |
US7799038B2 (en) | 2006-01-20 | 2010-09-21 | Boston Scientific Scimed, Inc. | Translumenal apparatus, system, and method |
US9044247B2 (en) | 2006-02-24 | 2015-06-02 | Terumo Kabushiki Kaisha | PFO closing device |
US8603139B2 (en) | 2006-02-24 | 2013-12-10 | Terumo Kabushiki Kaisha | PFO closing device |
US8172839B2 (en) | 2006-02-24 | 2012-05-08 | Terumo Kabushiki Kaisha | PFO closing device |
US8574265B2 (en) | 2006-02-24 | 2013-11-05 | Terumo Kabushiki Kaisha | PFO closing device |
US20070208364A1 (en) * | 2006-03-02 | 2007-09-06 | Kms Development, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US10123683B2 (en) * | 2006-03-02 | 2018-11-13 | Syntheon, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US8696639B2 (en) * | 2006-03-02 | 2014-04-15 | Syntheon, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US8092374B2 (en) | 2006-03-02 | 2012-01-10 | Kevin Smith | Variably flexible insertion device and method for variably flexing an insertion device |
US20120095491A1 (en) * | 2006-03-02 | 2012-04-19 | Smith Kevin W | Variably Flexible Insertion Device and Method for Variably Flexing an Insertion Device |
US9155451B2 (en) * | 2006-03-02 | 2015-10-13 | Syntheon, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US10835112B2 (en) | 2006-03-02 | 2020-11-17 | Syntheon, Llc | Variably flexible insertion device and method for variably flexing an insertion device |
US20150374211A1 (en) * | 2006-03-02 | 2015-12-31 | Syntheon, Llc | Variably Flexible Insertion Device and Method for Variably Flexing an Insertion Device |
US20140012085A1 (en) * | 2006-03-02 | 2014-01-09 | Syntheon, Llc | Variably Flexible Insertion Device and Method for Variably Flexing an Insertion Device |
US20070213582A1 (en) * | 2006-03-09 | 2007-09-13 | Zollinger Christopher J | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US20090043153A1 (en) * | 2006-03-09 | 2009-02-12 | Edwards Lifesciences Corporation | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US7871368B2 (en) | 2006-03-09 | 2011-01-18 | Edwards Lifesciences Corporation | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US7431692B2 (en) | 2006-03-09 | 2008-10-07 | Edwards Lifesciences Corporation | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US20090281500A1 (en) * | 2006-04-19 | 2009-11-12 | Acosta Pablo G | Devices, system and methods for minimally invasive abdominal surgical procedures |
US20090281498A1 (en) * | 2006-04-19 | 2009-11-12 | Acosta Pablo G | Devices, system and methods for minimally invasive abdominal surgical procedures |
US8808310B2 (en) | 2006-04-20 | 2014-08-19 | Integrated Vascular Systems, Inc. | Resettable clip applier and reset tools |
US7993303B2 (en) | 2006-04-21 | 2011-08-09 | Abbott Laboratories | Stiffening support catheter and methods for using the same |
WO2007124501A3 (en) * | 2006-04-21 | 2008-02-21 | Abbott Lab | Stiffening support catheter |
WO2007124501A2 (en) * | 2006-04-21 | 2007-11-01 | Abbott Laboratories | Stiffening support catheter |
US20070293846A1 (en) * | 2006-04-21 | 2007-12-20 | Abbott Laboratories | Dual Lumen Guidewire Support Catheter |
US20070293821A1 (en) * | 2006-04-21 | 2007-12-20 | Abbott Laboratories | Systems, Methods, and Devices for Injecting Media Contrast |
US7927305B2 (en) | 2006-04-21 | 2011-04-19 | Abbott Laboratories | Systems, methods, and devices for injecting media contrast |
US8206370B2 (en) | 2006-04-21 | 2012-06-26 | Abbott Laboratories | Dual lumen guidewire support catheter |
US8246574B2 (en) | 2006-04-21 | 2012-08-21 | Abbott Laboratories | Support catheter |
US20080065014A1 (en) * | 2006-04-21 | 2008-03-13 | Abbott Laboratories | Systems, Methods, and Devices to Facilitate Wire and Device Crossings of Obstructions in Body Lumens |
US20070250149A1 (en) * | 2006-04-21 | 2007-10-25 | Abbott Laboratories | Stiffening Support Catheters and Methods for Using the Same |
US9138250B2 (en) | 2006-04-24 | 2015-09-22 | Ethicon Endo-Surgery, Inc. | Medical instrument handle and medical instrument having a handle |
US20070250070A1 (en) * | 2006-04-24 | 2007-10-25 | Nobis Rudolph H | Medical instrument having a medical snare |
US8211114B2 (en) | 2006-04-24 | 2012-07-03 | Ethicon Endo-Surgery, Inc. | Medical instrument having a medical snare |
US20070250012A1 (en) * | 2006-04-24 | 2007-10-25 | Ifung Lu | Medical instrument having a medical needle-knife |
US20070250110A1 (en) * | 2006-04-24 | 2007-10-25 | Mattel, Inc. | Medical instrument handle and medical instrument having a handle |
US20070249908A1 (en) * | 2006-04-24 | 2007-10-25 | Ifung Lu | Medical cannula and medical cannula system |
US20070250111A1 (en) * | 2006-04-25 | 2007-10-25 | Ifung Lu | Medical instrument having an articulatable end effector |
US20070249905A1 (en) * | 2006-04-25 | 2007-10-25 | Nobis Rudolph H | Medical tubular assembly |
US7837620B2 (en) | 2006-04-25 | 2010-11-23 | Ethicon Endo-Surgery, Inc. | Medical tubular assembly |
US7927327B2 (en) | 2006-04-25 | 2011-04-19 | Ethicon Endo-Surgery, Inc. | Medical instrument having an articulatable end effector |
US7758593B2 (en) | 2006-05-04 | 2010-07-20 | Ethicon Endo-Surgery, Inc. | Medical instrument handle and medical instrument having same |
US20070260264A1 (en) * | 2006-05-04 | 2007-11-08 | Nobis Rudolph H | Medical instrument handle and medical instrument having same |
US20070282187A1 (en) * | 2006-05-11 | 2007-12-06 | Long Gary L | Medical instrument having a catheter and method for using a catheter |
US7597661B2 (en) | 2006-05-11 | 2009-10-06 | Ethicon Endo-Surgery, Inc. | Medical instrument having a catheter and method for using a catheter |
US20070270895A1 (en) * | 2006-05-16 | 2007-11-22 | Nobis Rudolph H | Medical instrument having a needle knife |
US7959642B2 (en) | 2006-05-16 | 2011-06-14 | Ethicon Endo-Surgery, Inc. | Medical instrument having a needle knife |
US20070270639A1 (en) * | 2006-05-17 | 2007-11-22 | Long Gary L | Medical instrument having a catheter and having a catheter accessory device and method for using |
US20070270649A1 (en) * | 2006-05-18 | 2007-11-22 | Long Gary L | Medical instrument including a catheter having a catheter stiffener and method for using |
US7892166B2 (en) | 2006-05-18 | 2011-02-22 | Ethicon Endo-Surgery, Inc. | Medical instrument including a catheter having a catheter stiffener and method for using |
US8556804B2 (en) * | 2006-05-22 | 2013-10-15 | Syntheon, Llc | Torque-transmitting, variably flexible insertion device and method for transmitting torque and variably flexing an insertion device |
US20070270648A1 (en) * | 2006-05-22 | 2007-11-22 | Kms Medical Llc | Torque-transmitting, variably flexible insertion device and method for transmitting torque and variably flexing an insertion device |
US20080017043A1 (en) * | 2006-06-01 | 2008-01-24 | The Coca-Cola Company | Tea Stick Brewing Package and Method |
US10470643B2 (en) | 2006-06-14 | 2019-11-12 | Intuitive Surgical Operations, Inc. | In-vivo visualization systems |
US11882996B2 (en) | 2006-06-14 | 2024-01-30 | Intuitive Surgical Operations, Inc. | In-vivo visualization systems |
US9962144B2 (en) | 2006-06-28 | 2018-05-08 | Abbott Laboratories | Vessel closure device |
US20080004640A1 (en) * | 2006-06-28 | 2008-01-03 | Abbott Laboratories | Vessel closure device |
US8556930B2 (en) | 2006-06-28 | 2013-10-15 | Abbott Laboratories | Vessel closure device |
US7798957B2 (en) * | 2006-07-31 | 2010-09-21 | Chang Stanley F | Colonoscope guide and method of use for improved colonoscopy |
US20080027281A1 (en) * | 2006-07-31 | 2008-01-31 | Chang Stanley F | Colonoscope guide and method of use for improved colonoscopy |
US7988621B2 (en) | 2006-08-10 | 2011-08-02 | Syntheon, Llc | Torque-transmitting, variably-flexible, corrugated insertion device and method for transmitting torque and variably flexing a corrugated insertion device |
US8298137B2 (en) | 2006-08-10 | 2012-10-30 | Syntheon, Llc | Method for transmitting torque and variably flexing a corrugated insertion device |
US20080039691A1 (en) * | 2006-08-10 | 2008-02-14 | Kms Development, Llc | Torque-transmitting, variably-flexible, corrugated insertion device and method for transmitting torque and variably flexing a corrugated insertion device |
US20110130628A1 (en) * | 2006-08-10 | 2011-06-02 | Smith Kevin W | Method for Transmitting Torque and Variably Flexing a Corrugated Insertion Device |
US8708894B2 (en) | 2006-08-10 | 2014-04-29 | Syntheon, Llc | Method for variably flexing and steering an insertion device |
US8292802B2 (en) | 2006-08-10 | 2012-10-23 | Syntheon, Llc | Method for transmitting torque and variably flexing a corrugated insertion device |
US10004388B2 (en) | 2006-09-01 | 2018-06-26 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
US10070772B2 (en) | 2006-09-01 | 2018-09-11 | Intuitive Surgical Operations, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
US11337594B2 (en) | 2006-09-01 | 2022-05-24 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
US11779195B2 (en) | 2006-09-01 | 2023-10-10 | Intuitive Surgical Operations, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
US8758398B2 (en) | 2006-09-08 | 2014-06-24 | Integrated Vascular Systems, Inc. | Apparatus and method for delivering a closure element |
US11660137B2 (en) | 2006-09-29 | 2023-05-30 | Boston Scientific Medical Device Limited | Connector system for electrosurgical device |
US11666377B2 (en) | 2006-09-29 | 2023-06-06 | Boston Scientific Medical Device Limited | Electrosurgical device |
US11744638B2 (en) | 2006-09-29 | 2023-09-05 | Boston Scientific Medical Device Limited | Electrosurgical device |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11344414B2 (en) | 2006-12-05 | 2022-05-31 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
US11559188B2 (en) | 2006-12-21 | 2023-01-24 | Intuitive Surgical Operations, Inc. | Off-axis visualization systems |
US10390685B2 (en) | 2006-12-21 | 2019-08-27 | Intuitive Surgical Operations, Inc. | Off-axis visualization systems |
US8133270B2 (en) | 2007-01-08 | 2012-03-13 | California Institute Of Technology | In-situ formation of a valve |
US8348999B2 (en) | 2007-01-08 | 2013-01-08 | California Institute Of Technology | In-situ formation of a valve |
US10226344B2 (en) | 2007-02-05 | 2019-03-12 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
US11504239B2 (en) | 2007-02-05 | 2022-11-22 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
US7967853B2 (en) | 2007-02-05 | 2011-06-28 | Boston Scientific Scimed, Inc. | Percutaneous valve, system and method |
US9421083B2 (en) | 2007-02-05 | 2016-08-23 | Boston Scientific Scimed Inc. | Percutaneous valve, system and method |
US8470023B2 (en) | 2007-02-05 | 2013-06-25 | Boston Scientific Scimed, Inc. | Percutaneous valve, system, and method |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US10258773B2 (en) | 2007-04-23 | 2019-04-16 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US9498603B2 (en) * | 2007-04-23 | 2016-11-22 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US20100305475A1 (en) * | 2007-04-23 | 2010-12-02 | Hinchliffe Peter W J | Guidewire with adjustable stiffness |
US20130131643A1 (en) * | 2007-04-23 | 2013-05-23 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US9387308B2 (en) * | 2007-04-23 | 2016-07-12 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US9387309B2 (en) * | 2007-04-23 | 2016-07-12 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US20130131644A1 (en) * | 2007-04-23 | 2013-05-23 | Cardioguidance Biomedical, Llc | Guidewire with adjustable stiffness |
US10092172B2 (en) * | 2007-05-08 | 2018-10-09 | Intuitive Surgical Operations, Inc. | Complex shape steerable tissue visualization and manipulation catheter |
US20140114129A1 (en) * | 2007-05-08 | 2014-04-24 | Intuitive Surgical Operations, Inc. | Complex Shape Steerable Tissue Visualization and Manipulation Catheter |
US20090005776A1 (en) * | 2007-06-25 | 2009-01-01 | Terumo Kabushiki Kaisha | Medical device |
US8382752B2 (en) | 2007-06-25 | 2013-02-26 | Terumo Kabushiki Kaisha | Medical device |
US20090005643A1 (en) * | 2007-06-27 | 2009-01-01 | Syntheon Llc | Torque-transmitting, variably-flexible, locking insertion device and method for operating the insertion device |
US9814372B2 (en) | 2007-06-27 | 2017-11-14 | Syntheon, Llc | Torque-transmitting, variably-flexible, locking insertion device and method for operating the insertion device |
US10806331B2 (en) | 2007-06-27 | 2020-10-20 | Syntheon, Llc | Torque-transmitting, variably-flexible, locking insertion device and method for operating the insertion device |
US8828079B2 (en) | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
DE102007040358A1 (en) | 2007-08-27 | 2009-03-05 | Technische Universität München | Trocar tube, trocar, obturator or rectoscope for transluminal endoscopic surgery over natural orifices |
WO2009027065A1 (en) | 2007-08-27 | 2009-03-05 | Technische Universität München | Trocar tube, trocar, obturator, or rectoscope for transluminal endoscopic surgery via natural body cavities |
US8597294B2 (en) | 2007-08-28 | 2013-12-03 | Terumo Kabushiki Kaisha | Biological tissue closing device |
US8920418B2 (en) | 2007-08-28 | 2014-12-30 | Terumo Kabushiki Kaisha | PFO closing device |
US20090069810A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Biological tissue closing device |
US8182481B2 (en) | 2007-08-28 | 2012-05-22 | Terumo Kabushiki Kaisha | PFO closing device |
US20090076525A1 (en) * | 2007-08-28 | 2009-03-19 | Terumo Kabushiki Kaisha | Pfo closing device |
US8460287B2 (en) | 2007-08-28 | 2013-06-11 | Terumo Kabushiki Kaisha | PFO closing device |
US20090069809A1 (en) * | 2007-08-28 | 2009-03-12 | Terumo Kabushiki Kaisha | Pfo closing device |
US20090105744A1 (en) * | 2007-10-17 | 2009-04-23 | Modesitt D Bruce | Methods for forming tracts in tissue |
US20090105729A1 (en) * | 2007-10-18 | 2009-04-23 | John Zentgraf | Minimally invasive repair of a valve leaflet in a beating heart |
US11419602B2 (en) | 2007-10-18 | 2022-08-23 | Neochord, Inc. | Minimally invasive repair of a valve leaflet in a beating heart |
US8758393B2 (en) | 2007-10-18 | 2014-06-24 | Neochord, Inc. | Minimally invasive repair of a valve leaflet in a beating heart |
US10507018B2 (en) | 2007-10-18 | 2019-12-17 | Neochord, Inc. | Minimally invasive repair of a valve leaflet in a beating heart |
US9192374B2 (en) | 2007-10-18 | 2015-11-24 | Neochord, Inc. | Minimally invasive repair of a valve leaflet in a beating heart |
US20090299282A1 (en) * | 2007-11-16 | 2009-12-03 | Osseon Therapeutics, Inc. | Steerable vertebroplasty system with a plurality of cavity creation elements |
US7842041B2 (en) | 2007-11-16 | 2010-11-30 | Osseon Therapeutics, Inc. | Steerable vertebroplasty system |
US8827981B2 (en) | 2007-11-16 | 2014-09-09 | Osseon Llc | Steerable vertebroplasty system with cavity creation element |
US9510885B2 (en) | 2007-11-16 | 2016-12-06 | Osseon Llc | Steerable and curvable cavity creation system |
US7811291B2 (en) | 2007-11-16 | 2010-10-12 | Osseon Therapeutics, Inc. | Closed vertebroplasty bone cement injection system |
US20090131886A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system |
US20090131950A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Vertebroplasty method with enhanced control |
US20090131867A1 (en) * | 2007-11-16 | 2009-05-21 | Liu Y King | Steerable vertebroplasty system with cavity creation element |
US20090182427A1 (en) * | 2007-12-06 | 2009-07-16 | Osseon Therapeutics, Inc. | Vertebroplasty implant with enhanced interfacial shear strength |
US8893947B2 (en) | 2007-12-17 | 2014-11-25 | Abbott Laboratories | Clip applier and methods of use |
US20110238089A1 (en) * | 2007-12-17 | 2011-09-29 | Abbott Laboratories | Tissue closure system and methods of use |
US8672953B2 (en) | 2007-12-17 | 2014-03-18 | Abbott Laboratories | Tissue closure system and methods of use |
US8820602B2 (en) | 2007-12-18 | 2014-09-02 | Abbott Laboratories | Modular clip applier |
US8137394B2 (en) | 2007-12-21 | 2012-03-20 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US8414641B2 (en) | 2007-12-21 | 2013-04-09 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US7892276B2 (en) | 2007-12-21 | 2011-02-22 | Boston Scientific Scimed, Inc. | Valve with delayed leaflet deployment |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10993805B2 (en) | 2008-02-26 | 2021-05-04 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11154398B2 (en) | 2008-02-26 | 2021-10-26 | JenaValve Technology. Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11660191B2 (en) | 2008-03-10 | 2023-05-30 | Edwards Lifesciences Corporation | Method to reduce mitral regurgitation |
US9282965B2 (en) | 2008-05-16 | 2016-03-15 | Abbott Laboratories | Apparatus and methods for engaging tissue |
US10413295B2 (en) | 2008-05-16 | 2019-09-17 | Abbott Laboratories | Engaging element for engaging tissue |
US8979882B2 (en) | 2008-07-21 | 2015-03-17 | Arstasis, Inc. | Devices, methods, and kits for forming tracts in tissue |
US20100016786A1 (en) * | 2008-07-21 | 2010-01-21 | Arstasis, Inc. | Devices, methods, and kits for forming tracts in tissue |
US20100016810A1 (en) * | 2008-07-21 | 2010-01-21 | Arstasis. Inc., | Devices and methods for forming tracts in tissue |
US10806575B2 (en) | 2008-08-22 | 2020-10-20 | Edwards Lifesciences Corporation | Heart valve treatment system |
US8657852B2 (en) | 2008-10-30 | 2014-02-25 | Abbott Vascular Inc. | Closure device |
US9241696B2 (en) | 2008-10-30 | 2016-01-26 | Abbott Vascular Inc. | Closure device |
US11116634B2 (en) | 2008-12-22 | 2021-09-14 | Valtech Cardio Ltd. | Annuloplasty implants |
US8858594B2 (en) | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
US10856986B2 (en) | 2008-12-22 | 2020-12-08 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices and adjustment mechanisms therefor |
US9314230B2 (en) | 2009-01-09 | 2016-04-19 | Abbott Vascular Inc. | Closure device with rapidly eroding anchor |
US9486191B2 (en) | 2009-01-09 | 2016-11-08 | Abbott Vascular, Inc. | Closure devices |
US20100179571A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9173644B2 (en) | 2009-01-09 | 2015-11-03 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9414820B2 (en) | 2009-01-09 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US20100179567A1 (en) * | 2009-01-09 | 2010-07-15 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US10537313B2 (en) | 2009-01-09 | 2020-01-21 | Abbott Vascular, Inc. | Closure devices and methods |
US11439378B2 (en) | 2009-01-09 | 2022-09-13 | Abbott Cardiovascular Systems, Inc. | Closure devices and methods |
US20110218568A1 (en) * | 2009-01-09 | 2011-09-08 | Voss Laveille K | Vessel closure devices, systems, and methods |
US9089311B2 (en) | 2009-01-09 | 2015-07-28 | Abbott Vascular Inc. | Vessel closure devices and methods |
US11284986B2 (en) | 2009-01-16 | 2022-03-29 | Claret Medical, Inc. | Intravascular blood filters and methods of use |
US10743977B2 (en) | 2009-01-16 | 2020-08-18 | Boston Scientific Scimed, Inc. | Intravascular blood filter |
US20110282379A1 (en) * | 2009-01-16 | 2011-11-17 | Michael Lee | Intravascular Blood Filters and Methods of Use |
US9414824B2 (en) | 2009-01-16 | 2016-08-16 | Abbott Vascular Inc. | Closure devices, systems, and methods |
US9326843B2 (en) * | 2009-01-16 | 2016-05-03 | Claret Medical, Inc. | Intravascular blood filters and methods of use |
US20140243877A9 (en) * | 2009-01-16 | 2014-08-28 | Claret Medical, Inc. | Intravascular blood filters and methods of use |
US11607301B2 (en) | 2009-01-16 | 2023-03-21 | Boston Scientific Scimed, Inc. | Intravascular blood filters and methods of use |
US9636205B2 (en) * | 2009-01-16 | 2017-05-02 | Claret Medical, Inc. | Intravascular blood filters and methods of use |
US11364106B2 (en) | 2009-01-16 | 2022-06-21 | Boston Scientific Scimed, Inc. | Intravascular blood filter |
US11202709B2 (en) | 2009-02-17 | 2021-12-21 | Valtech Cardio Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
US8905937B2 (en) | 2009-02-26 | 2014-12-09 | Integrated Vascular Systems, Inc. | Methods and apparatus for locating a surface of a body lumen |
US20100228191A1 (en) * | 2009-03-05 | 2010-09-09 | Hansen Medical, Inc. | Lockable support assembly and method |
US11766327B2 (en) | 2009-05-04 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Implantation of repair chords in the heart |
US11076958B2 (en) | 2009-05-04 | 2021-08-03 | Valtech Cardio, Ltd. | Annuloplasty ring delivery catheters |
US11844665B2 (en) | 2009-05-04 | 2023-12-19 | Edwards Lifesciences Innovation (Israel) Ltd. | Deployment techniques for annuloplasty structure |
US11185412B2 (en) | 2009-05-04 | 2021-11-30 | Valtech Cardio Ltd. | Deployment techniques for annuloplasty implants |
US11723774B2 (en) | 2009-05-07 | 2023-08-15 | Edwards Lifesciences Innovation (Israel) Ltd. | Multiple anchor delivery tool |
US10856987B2 (en) | 2009-05-07 | 2020-12-08 | Valtech Cardio, Ltd. | Multiple anchor delivery tool |
US8758231B2 (en) | 2009-05-14 | 2014-06-24 | Cook Medical Technologies Llc | Access sheath with active deflection |
US20110125178A1 (en) * | 2009-05-15 | 2011-05-26 | Michael Drews | Devices, methods and kits for forming tracts in tissue |
US11197681B2 (en) | 2009-05-20 | 2021-12-14 | Merit Medical Systems, Inc. | Steerable curvable vertebroplasty drill |
US20110022078A1 (en) * | 2009-07-23 | 2011-01-27 | Cameron Dale Hinman | Articulating mechanism |
US9221179B2 (en) | 2009-07-23 | 2015-12-29 | Intuitive Surgical Operations, Inc. | Articulating mechanism |
US11191631B2 (en) | 2009-07-27 | 2021-12-07 | Boston Scientific Scimed, Inc. | Dual endovascular filter and methods of use |
US10130458B2 (en) | 2009-07-27 | 2018-11-20 | Claret Medical, Inc. | Dual endovascular filter and methods of use |
US8974489B2 (en) | 2009-07-27 | 2015-03-10 | Claret Medical, Inc. | Dual endovascular filter and methods of use |
US20110054492A1 (en) * | 2009-08-26 | 2011-03-03 | Abbott Laboratories | Medical device for repairing a fistula |
US9585647B2 (en) | 2009-08-26 | 2017-03-07 | Abbott Laboratories | Medical device for repairing a fistula |
EP2633821A2 (en) | 2009-09-15 | 2013-09-04 | Evalve, Inc. | Device for cardiac valve repair |
US9060858B2 (en) | 2009-09-15 | 2015-06-23 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
EP3042615A1 (en) | 2009-09-15 | 2016-07-13 | Evalve, Inc. | Methods, systems and devices for cardiac valve repair |
EP3120811A2 (en) | 2009-09-17 | 2017-01-25 | Abbott Vascular | Methods, systems and devices for cardiac valve repair |
US20110208215A1 (en) * | 2009-09-22 | 2011-08-25 | Modesitt D Bruce | Devices, methods, and kits for forming tracts in tissue |
US11617652B2 (en) | 2009-10-29 | 2023-04-04 | Edwards Lifesciences Innovation (Israel) Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
US11141271B2 (en) | 2009-10-29 | 2021-10-12 | Valtech Cardio Ltd. | Tissue anchor for annuloplasty device |
US11602434B2 (en) | 2009-12-02 | 2023-03-14 | Edwards Lifesciences Innovation (Israel) Ltd. | Systems and methods for tissue adjustment |
US11911264B2 (en) | 2009-12-04 | 2024-02-27 | Edwards Lifesciences Corporation | Valve repair and replacement devices |
US11660185B2 (en) | 2009-12-04 | 2023-05-30 | Edwards Lifesciences Corporation | Ventricular anchors for valve repair and replacement devices |
US11583396B2 (en) | 2009-12-04 | 2023-02-21 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US10390820B2 (en) * | 2010-04-01 | 2019-08-27 | Karl Storz Se & Co. Kg | Medical instrument for microinvasive surgical interventions |
US20110245812A1 (en) * | 2010-04-01 | 2011-10-06 | Martin Blocher | Medical instrument for microinvasive surgical interventions |
US10624652B2 (en) | 2010-04-29 | 2020-04-21 | Dfine, Inc. | System for use in treatment of vertebral fractures |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
US8758399B2 (en) | 2010-08-02 | 2014-06-24 | Abbott Cardiovascular Systems, Inc. | Expandable bioabsorbable plug apparatus and method |
US8603116B2 (en) | 2010-08-04 | 2013-12-10 | Abbott Cardiovascular Systems, Inc. | Closure device with long tines |
US20160051331A1 (en) * | 2010-11-15 | 2016-02-25 | Intuitive Surgical Operations, Inc. | Actuation Cable Having Multiple Friction Characteristics |
US10159473B2 (en) * | 2010-11-15 | 2018-12-25 | Intuitive Surgical Operations, Inc. | Actuation cable having multiple friction characteristics |
US8821534B2 (en) | 2010-12-06 | 2014-09-02 | Integrated Vascular Systems, Inc. | Clip applier having improved hemostasis and methods of use |
US9770331B2 (en) | 2010-12-23 | 2017-09-26 | Twelve, Inc. | System for mitral valve repair and replacement |
US11571303B2 (en) | 2010-12-23 | 2023-02-07 | Twelve, Inc. | System for mitral valve repair and replacement |
US10517725B2 (en) | 2010-12-23 | 2019-12-31 | Twelve, Inc. | System for mitral valve repair and replacement |
US9421098B2 (en) | 2010-12-23 | 2016-08-23 | Twelve, Inc. | System for mitral valve repair and replacement |
US9044221B2 (en) | 2010-12-29 | 2015-06-02 | Neochord, Inc. | Exchangeable system for minimally invasive beating heart repair of heart valve leaflets |
US10080659B1 (en) | 2010-12-29 | 2018-09-25 | Neochord, Inc. | Devices and methods for minimally invasive repair of heart valves |
US10130474B2 (en) | 2010-12-29 | 2018-11-20 | Neochord, Inc. | Exchangeable system for minimally invasive beating heart repair of heart valve leaflets |
US11141258B2 (en) | 2010-12-30 | 2021-10-12 | Claret Medical, Inc. | Method of isolating the cerebral circulation during a cardiac procedure |
US9943395B2 (en) | 2010-12-30 | 2018-04-17 | Claret Medical, Inc. | Deflectable intravascular filter |
US9017364B2 (en) | 2010-12-30 | 2015-04-28 | Claret Medical, Inc. | Deflectable intravascular filter |
US9492264B2 (en) | 2010-12-30 | 2016-11-15 | Claret Medical, Inc. | Embolic protection device for protecting the cerebral vasculature |
US9055997B2 (en) | 2010-12-30 | 2015-06-16 | Claret Medical, Inc. | Method of isolating the cerebral circulation during a cardiac procedure |
US9345565B2 (en) | 2010-12-30 | 2016-05-24 | Claret Medical, Inc. | Steerable dual filter cerebral protection system |
US10058411B2 (en) | 2010-12-30 | 2018-08-28 | Claret Madical, Inc. | Method of isolating the cerebral circulation during a cardiac procedure |
US8876796B2 (en) | 2010-12-30 | 2014-11-04 | Claret Medical, Inc. | Method of accessing the left common carotid artery |
US9980805B2 (en) | 2010-12-30 | 2018-05-29 | Claret Medical, Inc. | Aortic embolic protection device |
US9259306B2 (en) | 2010-12-30 | 2016-02-16 | Claret Medical, Inc. | Aortic embolic protection device |
US9149276B2 (en) | 2011-03-21 | 2015-10-06 | Abbott Cardiovascular Systems, Inc. | Clip and deployment apparatus for tissue closure |
US10695178B2 (en) | 2011-06-01 | 2020-06-30 | Neochord, Inc. | Minimally invasive repair of heart valve leaflets |
US11712334B2 (en) | 2011-06-21 | 2023-08-01 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10751173B2 (en) | 2011-06-21 | 2020-08-25 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US9125740B2 (en) | 2011-06-21 | 2015-09-08 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10034750B2 (en) | 2011-06-21 | 2018-07-31 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US9585751B2 (en) | 2011-06-21 | 2017-03-07 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US9572662B2 (en) | 2011-06-21 | 2017-02-21 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US11523900B2 (en) | 2011-06-21 | 2022-12-13 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10028827B2 (en) | 2011-06-21 | 2018-07-24 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US9579196B2 (en) | 2011-06-21 | 2017-02-28 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US11039924B2 (en) | 2011-06-29 | 2021-06-22 | Mitralix Ltd. | Heart valve repair devices and methods |
US9956078B2 (en) | 2011-06-29 | 2018-05-01 | Mitralix Ltd. | Heart valve repair devices and methods |
US9364326B2 (en) | 2011-06-29 | 2016-06-14 | Mitralix Ltd. | Heart valve repair devices and methods |
US9668859B2 (en) | 2011-08-05 | 2017-06-06 | California Institute Of Technology | Percutaneous heart valve delivery systems |
US8940005B2 (en) | 2011-08-08 | 2015-01-27 | Gyrus Ent L.L.C. | Locking flexible surgical instruments |
EP3695795A1 (en) * | 2011-08-08 | 2020-08-19 | Gyrus ACMI, Inc. | Locking flexible surgical instruments |
WO2013022525A1 (en) * | 2011-08-08 | 2013-02-14 | Gyrus Ent, L.L.C. | Locking flexible surgical instruments |
US9572628B2 (en) | 2011-09-13 | 2017-02-21 | Medrobotics Corporation | Highly articulated probes with anti-twist link arrangement, methods of formation thereof, and methods of performing medical procedures |
US11141158B2 (en) | 2011-09-13 | 2021-10-12 | Abbott Cardiovascular Systems Inc. | Independent gripper |
US20170368681A1 (en) * | 2011-09-13 | 2017-12-28 | Medrobotics Corporation | Highly articulated probes with anti-twist link arrangement, methods of formation thereof, and methods of performing medical procedures |
US10792039B2 (en) | 2011-09-13 | 2020-10-06 | Abbott Cardiovascular Systems Inc. | Gripper pusher mechanism for tissue apposition systems |
US20140371764A1 (en) * | 2011-09-13 | 2014-12-18 | Medrobotics Corporation | Highly articulated probes with anti-twist link arrangement, methods of formation thereof, and methods of performing medical procedures |
US10743876B2 (en) | 2011-09-13 | 2020-08-18 | Abbott Cardiovascular Systems Inc. | System for fixation of leaflets of a heart valve |
US9757856B2 (en) * | 2011-09-13 | 2017-09-12 | Medrobotics Corporation | Highly articulated probes with anti-twist link arrangement, methods of formation thereof, and methods of performing medical procedures |
US9034033B2 (en) | 2011-10-19 | 2015-05-19 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9295552B2 (en) | 2011-10-19 | 2016-03-29 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10335278B2 (en) | 2011-10-19 | 2019-07-02 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10299927B2 (en) | 2011-10-19 | 2019-05-28 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11497603B2 (en) | 2011-10-19 | 2022-11-15 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11197758B2 (en) | 2011-10-19 | 2021-12-14 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US10945835B2 (en) | 2011-10-19 | 2021-03-16 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9034032B2 (en) | 2011-10-19 | 2015-05-19 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10016271B2 (en) | 2011-10-19 | 2018-07-10 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10052204B2 (en) | 2011-10-19 | 2018-08-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11826249B2 (en) | 2011-10-19 | 2023-11-28 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US11617648B2 (en) | 2011-10-19 | 2023-04-04 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10702380B2 (en) | 2011-10-19 | 2020-07-07 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US11628063B2 (en) | 2011-10-19 | 2023-04-18 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US10299917B2 (en) | 2011-10-19 | 2019-05-28 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9901443B2 (en) | 2011-10-19 | 2018-02-27 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11197759B2 (en) | 2011-11-04 | 2021-12-14 | Valtech Cardio Ltd. | Implant having multiple adjusting mechanisms |
US11857415B2 (en) | 2011-11-08 | 2024-01-02 | Edwards Lifesciences Innovation (Israel) Ltd. | Controlled steering functionality for implant-delivery tool |
US9332976B2 (en) | 2011-11-30 | 2016-05-10 | Abbott Cardiovascular Systems, Inc. | Tissue closure device |
US10249036B2 (en) | 2012-02-22 | 2019-04-02 | Veran Medical Technologies, Inc. | Surgical catheter having side exiting medical instrument and related systems and methods for four dimensional soft tissue navigation |
US10977789B2 (en) | 2012-02-22 | 2021-04-13 | Veran Medical Technologies, Inc. | Systems, methods and devices for forming respiratory-gated point cloud for four dimensional soft tissue navigation |
US10460437B2 (en) | 2012-02-22 | 2019-10-29 | Veran Medical Technologies, Inc. | Method for placing a localization element in an organ of a patient for four dimensional soft tissue navigation |
US20130225943A1 (en) * | 2012-02-22 | 2013-08-29 | Veran Medical Technologies, Inc. | Steerable surgical catheter having biopsy devices and related systems and methods for four dimensional soft tissue navigation |
US9972082B2 (en) * | 2012-02-22 | 2018-05-15 | Veran Medical Technologies, Inc. | Steerable surgical catheter having biopsy devices and related systems and methods for four dimensional soft tissue navigation |
US11551359B2 (en) | 2012-02-22 | 2023-01-10 | Veran Medical Technologies, Inc | Systems, methods and devices for forming respiratory-gated point cloud for four dimensional soft tissue navigation |
US11830198B2 (en) | 2012-02-22 | 2023-11-28 | Veran Medical Technologies, Inc. | Systems, methods and devices for forming respiratory-gated point cloud for four dimensional soft tissue navigation |
US11403753B2 (en) | 2012-02-22 | 2022-08-02 | Veran Medical Technologies, Inc. | Surgical catheter having side exiting medical instrument and related systems and methods for four dimensional soft tissue navigation |
US10140704B2 (en) | 2012-02-22 | 2018-11-27 | Veran Medical Technologies, Inc. | Systems, methods and devices for forming respiratory-gated point cloud for four dimensional soft tissue navigation |
EP2816966A4 (en) * | 2012-02-22 | 2015-11-11 | Veran Medical Tech Inc | Systems, methods, and devices for four dimensional soft tissue navigation |
US11129714B2 (en) | 2012-03-01 | 2021-09-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US10258468B2 (en) | 2012-03-01 | 2019-04-16 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US10441753B2 (en) | 2012-05-25 | 2019-10-15 | Arstasis, Inc. | Vascular access configuration |
US10675447B2 (en) | 2012-05-25 | 2020-06-09 | Arstasis, Inc. | Vascular access configuration |
US11684447B2 (en) | 2012-05-31 | 2023-06-27 | Boston Scientific Medical Device Limited | Radiofrequency perforation apparatus |
US20190150908A1 (en) * | 2012-06-29 | 2019-05-23 | Neotract, Inc. | Flexible system for delivering an anchor |
US11331093B2 (en) * | 2012-06-29 | 2022-05-17 | Teleflex Life Sciences Limited | Flexible system for delivering an anchor |
US11395648B2 (en) | 2012-09-29 | 2022-07-26 | Edwards Lifesciences Corporation | Plication lock delivery system and method of use thereof |
US11344310B2 (en) | 2012-10-23 | 2022-05-31 | Valtech Cardio Ltd. | Percutaneous tissue anchor techniques |
US10893939B2 (en) | 2012-10-23 | 2021-01-19 | Valtech Cardio, Ltd. | Controlled steering functionality for implant delivery tool |
US11890190B2 (en) | 2012-10-23 | 2024-02-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Location indication system for implant-delivery tool |
US11583400B2 (en) | 2012-12-06 | 2023-02-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for guided advancement of a tool |
US9364209B2 (en) | 2012-12-21 | 2016-06-14 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
US10537312B2 (en) | 2012-12-21 | 2020-01-21 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
US11672518B2 (en) | 2012-12-21 | 2023-06-13 | Abbott Cardiovascular Systems, Inc. | Articulating suturing device |
US10918374B2 (en) | 2013-02-26 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US11793505B2 (en) | 2013-02-26 | 2023-10-24 | Edwards Lifesciences Corporation | Devices and methods for percutaneous tricuspid valve repair |
US10080657B2 (en) | 2013-03-07 | 2018-09-25 | Cedars-Sinai Medical Center | Catheter based apical approach heart prostheses delivery system |
US10105221B2 (en) | 2013-03-07 | 2018-10-23 | Cedars-Sinai Medical Center | Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis |
US11730591B2 (en) | 2013-03-07 | 2023-08-22 | Cedars-Sinai Medical | Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis |
US10898323B2 (en) | 2013-03-07 | 2021-01-26 | Cedars-Sinai Medical Center | Catheter based apical approach heart prostheses delivery system |
US11937873B2 (en) | 2013-03-12 | 2024-03-26 | Boston Scientific Medical Device Limited | Electrosurgical device having a lumen |
US11534583B2 (en) | 2013-03-14 | 2022-12-27 | Valtech Cardio Ltd. | Guidewire feeder |
US11850140B2 (en) | 2013-03-14 | 2023-12-26 | Teleflex Life Sciences Limited | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US10912637B2 (en) | 2013-03-14 | 2021-02-09 | Neotract, Inc. | Devices, systems and methods for treating benign prostatic hyperplasia and other conditions |
US11890194B2 (en) | 2013-03-15 | 2024-02-06 | Edwards Lifesciences Corporation | Translation catheters, systems, and methods of use thereof |
US9744037B2 (en) | 2013-03-15 | 2017-08-29 | California Institute Of Technology | Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves |
US20150005704A1 (en) * | 2013-05-07 | 2015-01-01 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Steerable Medical Device Having Multiple Curve Profiles |
US11234821B2 (en) | 2013-05-20 | 2022-02-01 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US10111747B2 (en) | 2013-05-20 | 2018-10-30 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11744573B2 (en) | 2013-08-31 | 2023-09-05 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US10918373B2 (en) | 2013-08-31 | 2021-02-16 | Edwards Lifesciences Corporation | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
US20150105721A1 (en) * | 2013-10-10 | 2015-04-16 | Oscor Inc. | Steerable medical devices |
US11766263B2 (en) | 2013-10-23 | 2023-09-26 | Edwards Lifesciences Innovation (Israel) Ltd. | Anchor magazine |
US11065001B2 (en) | 2013-10-23 | 2021-07-20 | Valtech Cardio, Ltd. | Anchor magazine |
US10973637B2 (en) | 2013-12-26 | 2021-04-13 | Valtech Cardio, Ltd. | Implantation of flexible implant |
US11666433B2 (en) | 2014-03-17 | 2023-06-06 | Evalve, Inc. | Double orifice device for transcatheter mitral valve replacement |
US10390943B2 (en) | 2014-03-17 | 2019-08-27 | Evalve, Inc. | Double orifice device for transcatheter mitral valve replacement |
US10667804B2 (en) | 2014-03-17 | 2020-06-02 | Evalve, Inc. | Mitral valve fixation device removal devices and methods |
US10098738B2 (en) | 2014-06-26 | 2018-10-16 | Mitralix Ltd. | Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices |
US10864079B2 (en) | 2014-06-26 | 2020-12-15 | Mitralix Ltd. | Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices |
US9700412B2 (en) | 2014-06-26 | 2017-07-11 | Mitralix Ltd. | Heart valve repair devices for placement in ventricle and delivery systems for implanting heart valve repair devices |
US11116589B2 (en) | 2014-09-04 | 2021-09-14 | Memic Innovative Surgery Ltd. | Control of device including mechanical arms |
US11517378B2 (en) * | 2014-09-04 | 2022-12-06 | Momentis Surgical Ltd | Device and system including mechanical arms |
US20170071688A1 (en) * | 2014-09-04 | 2017-03-16 | Memic Innovative Surgery Ltd. | Device and system including mechanical arms |
US10799359B2 (en) | 2014-09-10 | 2020-10-13 | Cedars-Sinai Medical Center | Method and apparatus for percutaneous delivery and deployment of a cardiac valve prosthesis |
US11071628B2 (en) | 2014-10-14 | 2021-07-27 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
US10660625B2 (en) | 2014-11-04 | 2020-05-26 | Abbott Cardiovascular Systems, Inc. | One-way actuator knob |
US10758265B2 (en) | 2014-11-14 | 2020-09-01 | Cedars-Sinai Medical Center | Cardiovascular access and device delivery system |
US11653948B2 (en) | 2014-11-14 | 2023-05-23 | Cedars-Sinai Medical Center | Cardiovascular access and device delivery system |
US11690621B2 (en) | 2014-12-04 | 2023-07-04 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
US10524792B2 (en) | 2014-12-04 | 2020-01-07 | Edwards Lifesciences Corporation | Percutaneous clip for repairing a heart valve |
US11229435B2 (en) | 2014-12-19 | 2022-01-25 | Abbott Cardiovascular Systems Inc. | Grasping for tissue repair |
US10188392B2 (en) | 2014-12-19 | 2019-01-29 | Abbott Cardiovascular Systems, Inc. | Grasping for tissue repair |
US11109863B2 (en) | 2014-12-19 | 2021-09-07 | Abbott Cardiovascular Systems, Inc. | Grasping for tissue repair |
US11006956B2 (en) | 2014-12-19 | 2021-05-18 | Abbott Cardiovascular Systems Inc. | Grasping for tissue repair |
US10925610B2 (en) | 2015-03-05 | 2021-02-23 | Edwards Lifesciences Corporation | Devices for treating paravalvular leakage and methods use thereof |
US10524912B2 (en) | 2015-04-02 | 2020-01-07 | Abbott Cardiovascular Systems, Inc. | Tissue fixation devices and methods |
US10893941B2 (en) | 2015-04-02 | 2021-01-19 | Abbott Cardiovascular Systems, Inc. | Tissue fixation devices and methods |
US9566144B2 (en) | 2015-04-22 | 2017-02-14 | Claret Medical, Inc. | Vascular filters, deflectors, and methods |
US10449028B2 (en) | 2015-04-22 | 2019-10-22 | Claret Medical, Inc. | Vascular filters, deflectors, and methods |
US11020227B2 (en) | 2015-04-30 | 2021-06-01 | Valtech Cardio, Ltd. | Annuloplasty technologies |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
EP3294399A4 (en) * | 2015-05-12 | 2019-03-20 | Rhythm Xience, Inc. | Catheter system for left heart access |
WO2016183300A2 (en) | 2015-05-12 | 2016-11-17 | Rhythm Xience, Inc. | Catheter system for left heart access |
US11793642B2 (en) | 2015-05-14 | 2023-10-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10517726B2 (en) | 2015-05-14 | 2019-12-31 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US20170020567A1 (en) * | 2015-05-19 | 2017-01-26 | Rhythm Xience, Inc. | Catheter System for Left Heart Access |
US11660119B2 (en) | 2015-05-19 | 2023-05-30 | Medtronic, Inc. | Catheter system for left heart access |
US20160338729A1 (en) * | 2015-05-19 | 2016-11-24 | Jim Hassett | Catheter system for left heart access |
US11590321B2 (en) | 2015-06-19 | 2023-02-28 | Evalve, Inc. | Catheter guiding system and methods |
US10376673B2 (en) | 2015-06-19 | 2019-08-13 | Evalve, Inc. | Catheter guiding system and methods |
US10238494B2 (en) | 2015-06-29 | 2019-03-26 | Evalve, Inc. | Self-aligning radiopaque ring |
US10856988B2 (en) | 2015-06-29 | 2020-12-08 | Evalve, Inc. | Self-aligning radiopaque ring |
US11096691B2 (en) | 2015-07-21 | 2021-08-24 | Evalve, Inc. | Tissue grasping devices and related methods |
US11759209B2 (en) | 2015-07-21 | 2023-09-19 | Evalve, Inc. | Tissue grasping devices and related methods |
US10667815B2 (en) | 2015-07-21 | 2020-06-02 | Evalve, Inc. | Tissue grasping devices and related methods |
US11241308B2 (en) | 2015-07-23 | 2022-02-08 | Cedars-Sinai Medical Center | Device for securing heart valve leaflets |
US10413408B2 (en) | 2015-08-06 | 2019-09-17 | Evalve, Inc. | Delivery catheter systems, methods, and devices |
US10820996B2 (en) | 2015-08-21 | 2020-11-03 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US10238490B2 (en) | 2015-08-21 | 2019-03-26 | Twelve, Inc. | Implant heart valve devices, mitral valve repair devices and associated systems and methods |
US11576782B2 (en) | 2015-08-21 | 2023-02-14 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US11219351B2 (en) | 2015-09-03 | 2022-01-11 | Neptune Medical Inc. | Device for endoscopic advancement through the small intestine |
US11723728B2 (en) | 2015-09-04 | 2023-08-15 | Momentis Surgical Ltd. | Actuation of a device comprising mechanical arms |
US11766290B2 (en) | 2015-09-09 | 2023-09-26 | Boston Scientific Medical Device Limited | Epicardial access system and methods |
US20170086900A1 (en) * | 2015-09-24 | 2017-03-30 | Medidata Sp. Z O.O. | Cryoapplicator for minimally invasive surgical cardiac ablation |
US10893898B2 (en) * | 2015-09-24 | 2021-01-19 | Medidata Sp. Zo.O | Cryoapplicator for minimally invasive surgical cardiac ablation |
US11484409B2 (en) | 2015-10-01 | 2022-11-01 | Neochord, Inc. | Ringless web for repair of heart valves |
US10765517B2 (en) | 2015-10-01 | 2020-09-08 | Neochord, Inc. | Ringless web for repair of heart valves |
US10238495B2 (en) | 2015-10-09 | 2019-03-26 | Evalve, Inc. | Delivery catheter handle and methods of use |
US11931263B2 (en) | 2015-10-09 | 2024-03-19 | Evalve, Inc. | Delivery catheter handle and methods of use |
US11109972B2 (en) | 2015-10-09 | 2021-09-07 | Evalve, Inc. | Delivery catheter handle and methods of use |
US10828160B2 (en) | 2015-12-30 | 2020-11-10 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US11890193B2 (en) | 2015-12-30 | 2024-02-06 | Edwards Lifesciences Corporation | System and method for reducing tricuspid regurgitation |
US11833034B2 (en) | 2016-01-13 | 2023-12-05 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US11246705B2 (en) * | 2016-02-10 | 2022-02-15 | Abbott Cardiovascular Systems Inc. | System and method for implant delivery |
US10617481B2 (en) | 2016-03-09 | 2020-04-14 | Memic Innovative Surgey Ltd. | Modular device comprising mechanical arms |
US11771511B2 (en) | 2016-03-09 | 2023-10-03 | Momentis Surgical Ltd | Modular device comprising mechanical arms |
US10799676B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11219746B2 (en) | 2016-03-21 | 2022-01-11 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11951263B2 (en) | 2016-03-21 | 2024-04-09 | Edwards Lifesciences Corporation | Multi-direction steerable handles |
US10835714B2 (en) | 2016-03-21 | 2020-11-17 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799677B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US10799675B2 (en) | 2016-03-21 | 2020-10-13 | Edwards Lifesciences Corporation | Cam controlled multi-direction steerable handles |
WO2017180419A1 (en) * | 2016-04-14 | 2017-10-19 | Baylor College Of Medicine | Sheaths, methods of use, and kits including the same |
US11033390B2 (en) | 2016-04-29 | 2021-06-15 | Medtronic Vascular, Inc. | Prosthetic heart valve devices with tethered anchors and associated systems and methods |
US10265172B2 (en) | 2016-04-29 | 2019-04-23 | Medtronic Vascular, Inc. | Prosthetic heart valve devices with tethered anchors and associated systems and methods |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11540835B2 (en) | 2016-05-26 | 2023-01-03 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US11963712B2 (en) | 2016-06-20 | 2024-04-23 | Evalve, Inc. | Transapical removal device |
US10736632B2 (en) | 2016-07-06 | 2020-08-11 | Evalve, Inc. | Methods and devices for valve clip excision |
US10973638B2 (en) | 2016-07-07 | 2021-04-13 | Edwards Lifesciences Corporation | Device and method for treating vascular insufficiency |
US10959845B2 (en) | 2016-07-08 | 2021-03-30 | Valtech Cardio, Ltd. | Adjustable annuloplasty device with alternating peaks and troughs |
US11944277B2 (en) | 2016-08-18 | 2024-04-02 | Neptune Medical Inc. | Device and method for enhanced visualization of the small intestine |
US11122971B2 (en) | 2016-08-18 | 2021-09-21 | Neptune Medical Inc. | Device and method for enhanced visualization of the small intestine |
US11653947B2 (en) | 2016-10-05 | 2023-05-23 | Evalve, Inc. | Cardiac valve cutting device |
US11071564B2 (en) | 2016-10-05 | 2021-07-27 | Evalve, Inc. | Cardiac valve cutting device |
US11344350B2 (en) | 2016-10-27 | 2022-05-31 | Dfine, Inc. | Articulating osteotome with cement delivery channel and method of use |
US10478241B2 (en) | 2016-10-27 | 2019-11-19 | Merit Medical Systems, Inc. | Articulating osteotome with cement delivery channel |
US11517718B2 (en) | 2016-11-07 | 2022-12-06 | Edwards Lifesciences Corporation | Apparatus for the introduction and manipulation of multiple telescoping catheters |
US11166818B2 (en) | 2016-11-09 | 2021-11-09 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10363138B2 (en) | 2016-11-09 | 2019-07-30 | Evalve, Inc. | Devices for adjusting the curvature of cardiac valve structures |
US10398553B2 (en) | 2016-11-11 | 2019-09-03 | Evalve, Inc. | Opposing disk device for grasping cardiac valve tissue |
US10398552B2 (en) | 2016-11-15 | 2019-09-03 | Abbott Cardiovascular Systems Inc. | Fixation devices, systems and methods for heart valve leaf repair |
US10426616B2 (en) | 2016-11-17 | 2019-10-01 | Evalve, Inc. | Cardiac implant delivery system |
US11026744B2 (en) | 2016-11-28 | 2021-06-08 | Dfine, Inc. | Tumor ablation devices and related methods |
US11116570B2 (en) | 2016-11-28 | 2021-09-14 | Dfine, Inc. | Tumor ablation devices and related methods |
US11957358B2 (en) | 2016-12-08 | 2024-04-16 | Evalve, Inc. | Adjustable arm device for grasping tissues |
US10779837B2 (en) | 2016-12-08 | 2020-09-22 | Evalve, Inc. | Adjustable arm device for grasping tissues |
US11540842B2 (en) | 2016-12-09 | 2023-01-03 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
US10470781B2 (en) | 2016-12-09 | 2019-11-12 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
US10463380B2 (en) | 2016-12-09 | 2019-11-05 | Dfine, Inc. | Medical devices for treating hard tissues and related methods |
US10314586B2 (en) | 2016-12-13 | 2019-06-11 | Evalve, Inc. | Rotatable device and method for fixing tricuspid valve tissue |
US11406388B2 (en) | 2016-12-13 | 2022-08-09 | Evalve, Inc. | Rotatable device and method for fixing tricuspid valve tissue |
US11291354B2 (en) * | 2016-12-22 | 2022-04-05 | Olympus Corporation | Flexible tube insertion apparatus and flexible tube insertion method |
US11931262B2 (en) | 2016-12-30 | 2024-03-19 | Pipeline Medical Technologies, Inc. | Method and apparatus for transvascular implantation of neo chordae tendinae |
US11696828B2 (en) | 2016-12-30 | 2023-07-11 | Pipeline Medical Technologies, Inc. | Method and apparatus for mitral valve chord repair |
US11684475B2 (en) | 2016-12-30 | 2023-06-27 | Pipeline Medical Technologies, Inc. | Method and apparatus for transvascular implantation of neo chordae tendinae |
US11690719B2 (en) | 2016-12-30 | 2023-07-04 | Pipeline Medical Technologies, Inc. | Leaflet capture and anchor deployment system |
US11083580B2 (en) | 2016-12-30 | 2021-08-10 | Pipeline Medical Technologies, Inc. | Method of securing a leaflet anchor to a mitral valve leaflet |
US11666441B2 (en) | 2016-12-30 | 2023-06-06 | Pipeline Medical Technologies, Inc. | Endovascular suture lock |
US10905554B2 (en) | 2017-01-05 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve coaptation device |
US11607230B2 (en) | 2017-01-06 | 2023-03-21 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
US10660656B2 (en) | 2017-01-06 | 2020-05-26 | Dfine, Inc. | Osteotome with a distal portion for simultaneous advancement and articulation |
US11439501B2 (en) | 2017-01-25 | 2022-09-13 | Cedars-Sinai Medical Center | Device for securing heart valve leaflets |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US20180344981A1 (en) * | 2017-02-07 | 2018-12-06 | Qmax, Llc | Deflectable catheter with compound curve articulation and materials for the same |
US11826524B2 (en) * | 2017-02-07 | 2023-11-28 | Qmax, Llc | Deflectable catheter with compound curve articulation and materials for the same |
US11337790B2 (en) | 2017-02-22 | 2022-05-24 | Boston Scientific Scimed, Inc. | Systems and methods for protecting the cerebral vasculature |
US11779410B2 (en) | 2017-03-09 | 2023-10-10 | Momentis Surgical Ltd | Control console including an input arm for control of a surgical mechanical arm |
US10973592B2 (en) | 2017-03-09 | 2021-04-13 | Memie Innovative Surgery Ltd. | Control console for surgical device with mechanical arms |
US11083528B2 (en) | 2017-03-09 | 2021-08-10 | Memic Innovative Surgery Ltd. | Input arm for control of a surgical mechanical arm |
US20200022754A1 (en) * | 2017-03-24 | 2020-01-23 | Robert J. Cottone | Systems and methods for tissue displacement |
US20190374746A1 (en) * | 2017-03-30 | 2019-12-12 | University Of Hawaii | Steerable surgical devices with shape memory alloy wires |
US10806898B2 (en) * | 2017-03-30 | 2020-10-20 | University Of Hawaii | Steerable surgical devices with shape memory alloy wires |
US11589989B2 (en) | 2017-03-31 | 2023-02-28 | Neochord, Inc. | Minimally invasive heart valve repair in a beating heart |
US10751507B2 (en) | 2017-04-10 | 2020-08-25 | Syn Variflex, Llc | Thermally controlled variable-flexibility catheters and methods of manufacturing same |
US10905553B2 (en) | 2017-04-18 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10849754B2 (en) | 2017-04-18 | 2020-12-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10507108B2 (en) | 2017-04-18 | 2019-12-17 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10524913B2 (en) | 2017-04-18 | 2020-01-07 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10959848B2 (en) | 2017-04-18 | 2021-03-30 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10952853B2 (en) | 2017-04-18 | 2021-03-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US10945843B2 (en) | 2017-04-18 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10940005B2 (en) | 2017-04-18 | 2021-03-09 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11000373B2 (en) | 2017-04-18 | 2021-05-11 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11883611B2 (en) | 2017-04-18 | 2024-01-30 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US11234822B2 (en) | 2017-04-18 | 2022-02-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11602431B2 (en) | 2017-04-18 | 2023-03-14 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11224511B2 (en) | 2017-04-18 | 2022-01-18 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10932908B2 (en) | 2017-04-18 | 2021-03-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11389295B2 (en) | 2017-04-18 | 2022-07-19 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10667912B2 (en) | 2017-04-18 | 2020-06-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US11850153B2 (en) | 2017-04-18 | 2023-12-26 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10925732B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11179240B2 (en) | 2017-04-18 | 2021-11-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11013601B2 (en) | 2017-04-18 | 2021-05-25 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11020229B2 (en) | 2017-04-18 | 2021-06-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10925734B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10925733B2 (en) | 2017-04-18 | 2021-02-23 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11160657B2 (en) | 2017-04-18 | 2021-11-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US11058539B2 (en) | 2017-04-18 | 2021-07-13 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10918482B2 (en) | 2017-04-18 | 2021-02-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11723772B2 (en) | 2017-04-18 | 2023-08-15 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10905552B2 (en) | 2017-04-18 | 2021-02-02 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10898327B2 (en) | 2017-04-18 | 2021-01-26 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11737873B2 (en) | 2017-04-18 | 2023-08-29 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US11096784B2 (en) | 2017-04-18 | 2021-08-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10888425B2 (en) | 2017-04-18 | 2021-01-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10874514B2 (en) | 2017-04-18 | 2020-12-29 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10842627B2 (en) | 2017-04-18 | 2020-11-24 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11654021B2 (en) | 2017-04-18 | 2023-05-23 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10869763B2 (en) | 2017-04-18 | 2020-12-22 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11166778B2 (en) | 2017-04-28 | 2021-11-09 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US10799312B2 (en) | 2017-04-28 | 2020-10-13 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
US11406468B2 (en) | 2017-04-28 | 2022-08-09 | Edwards Lifesciences Corporation | Medical device stabilizing apparatus and method of use |
CN110730675A (en) * | 2017-05-05 | 2020-01-24 | 富利凯(集团)有限公司 | Intubation device |
WO2018202720A1 (en) * | 2017-05-05 | 2018-11-08 | Flexicare (Group) Limited | Intubation devices |
US11786681B2 (en) | 2017-05-05 | 2023-10-17 | Flexicare (Group) Limited | Intubation devices |
US10959846B2 (en) | 2017-05-10 | 2021-03-30 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10646342B1 (en) | 2017-05-10 | 2020-05-12 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US10820998B2 (en) | 2017-05-10 | 2020-11-03 | Edwards Lifesciences Corporation | Valve repair device |
US11786370B2 (en) | 2017-05-11 | 2023-10-17 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US11065119B2 (en) | 2017-05-12 | 2021-07-20 | Evalve, Inc. | Long arm valve repair clip |
US20180333042A1 (en) * | 2017-05-18 | 2018-11-22 | Loubert S. Suddaby | Self-anchoring endoscopy sheath |
US11559398B2 (en) | 2017-06-02 | 2023-01-24 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US11464659B2 (en) | 2017-06-06 | 2022-10-11 | Twelve, Inc. | Crimping device for loading stents and prosthetic heart valves |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US11877926B2 (en) | 2017-07-06 | 2024-01-23 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US20200121894A1 (en) * | 2017-07-27 | 2020-04-23 | Evalve, Inc. | Intravascular delivery system with centralized steering |
US11051940B2 (en) | 2017-09-07 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic spacer device for heart valve |
US11730598B2 (en) | 2017-09-07 | 2023-08-22 | Edwards Lifesciences Corporation | Prosthetic device for heart valve |
US11065117B2 (en) | 2017-09-08 | 2021-07-20 | Edwards Lifesciences Corporation | Axisymmetric adjustable device for treating mitral regurgitation |
US11040174B2 (en) | 2017-09-19 | 2021-06-22 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11110251B2 (en) | 2017-09-19 | 2021-09-07 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11944762B2 (en) | 2017-09-19 | 2024-04-02 | Edwards Lifesciences Corporation | Multi-direction steerable handles for steering catheters |
US11191630B2 (en) | 2017-10-27 | 2021-12-07 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US11832784B2 (en) | 2017-11-02 | 2023-12-05 | Edwards Lifesciences Innovation (Israel) Ltd. | Implant-cinching devices and systems |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
US11878131B2 (en) | 2017-12-05 | 2024-01-23 | Boston Scientific Medical Device Limited | Transseptal guide wire puncture system |
US11154390B2 (en) | 2017-12-19 | 2021-10-26 | Claret Medical, Inc. | Systems for protection of the cerebral vasculature during a cardiac procedure |
US11672520B2 (en) | 2017-12-23 | 2023-06-13 | Teleflex Life Sciences Limited | Expandable tissue engagement apparatus and method |
US10238493B1 (en) | 2018-01-09 | 2019-03-26 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10507109B2 (en) | 2018-01-09 | 2019-12-17 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10245144B1 (en) | 2018-01-09 | 2019-04-02 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11850154B2 (en) | 2018-01-09 | 2023-12-26 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11298228B2 (en) | 2018-01-09 | 2022-04-12 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10076415B1 (en) | 2018-01-09 | 2018-09-18 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10130475B1 (en) | 2018-01-09 | 2018-11-20 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10959847B2 (en) | 2018-01-09 | 2021-03-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11918469B2 (en) | 2018-01-09 | 2024-03-05 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11612485B2 (en) | 2018-01-09 | 2023-03-28 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11259927B2 (en) | 2018-01-09 | 2022-03-01 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10111751B1 (en) | 2018-01-09 | 2018-10-30 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10973639B2 (en) | 2018-01-09 | 2021-04-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10231837B1 (en) | 2018-01-09 | 2019-03-19 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10595997B2 (en) | 2018-01-09 | 2020-03-24 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10123873B1 (en) | 2018-01-09 | 2018-11-13 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10105222B1 (en) | 2018-01-09 | 2018-10-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11013598B2 (en) | 2018-01-09 | 2021-05-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11547564B2 (en) | 2018-01-09 | 2023-01-10 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10925735B2 (en) | 2018-01-09 | 2021-02-23 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11039925B2 (en) | 2018-01-09 | 2021-06-22 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10136993B1 (en) | 2018-01-09 | 2018-11-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10159570B1 (en) | 2018-01-09 | 2018-12-25 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10813760B2 (en) | 2018-01-09 | 2020-10-27 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US10918483B2 (en) | 2018-01-09 | 2021-02-16 | Edwards Lifesciences Corporation | Native valve repair devices and procedures |
US11779463B2 (en) | 2018-01-24 | 2023-10-10 | Edwards Lifesciences Innovation (Israel) Ltd. | Contraction of an annuloplasty structure |
US11666442B2 (en) | 2018-01-26 | 2023-06-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
US11291544B2 (en) | 2018-02-02 | 2022-04-05 | Cedars-Sinai Medical Center | Delivery platforms, devices, and methods for tricuspid valve repair |
US11285003B2 (en) | 2018-03-20 | 2022-03-29 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US11701228B2 (en) | 2018-03-20 | 2023-07-18 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11026791B2 (en) | 2018-03-20 | 2021-06-08 | Medtronic Vascular, Inc. | Flexible canopy valve repair systems and methods of use |
US11931261B2 (en) | 2018-03-20 | 2024-03-19 | Medtronic Vascular, Inc. | Prolapse prevention device and methods of use thereof |
US10588620B2 (en) | 2018-03-23 | 2020-03-17 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
US11612389B2 (en) | 2018-03-23 | 2023-03-28 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
US11389297B2 (en) | 2018-04-12 | 2022-07-19 | Edwards Lifesciences Corporation | Mitral valve spacer device |
US11207181B2 (en) | 2018-04-18 | 2021-12-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11439491B2 (en) | 2018-04-26 | 2022-09-13 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US11957584B2 (en) | 2018-05-09 | 2024-04-16 | Neochord, Inc. | Suture length adjustment for minimally invasive heart valve repair |
US11253360B2 (en) | 2018-05-09 | 2022-02-22 | Neochord, Inc. | Low profile tissue anchor for minimally invasive heart valve repair |
US11173030B2 (en) | 2018-05-09 | 2021-11-16 | Neochord, Inc. | Suture length adjustment for minimally invasive heart valve repair |
US11123191B2 (en) | 2018-07-12 | 2021-09-21 | Valtech Cardio Ltd. | Annuloplasty systems and locking tools therefor |
US11890191B2 (en) | 2018-07-12 | 2024-02-06 | Edwards Lifesciences Innovation (Israel) Ltd. | Fastener and techniques therefor |
US11724065B2 (en) | 2018-07-19 | 2023-08-15 | Neptune Medical Inc. | Nested rigidizing devices |
US11135398B2 (en) | 2018-07-19 | 2021-10-05 | Neptune Medical Inc. | Dynamically rigidizing composite medical structures |
US11478608B2 (en) | 2018-07-19 | 2022-10-25 | Neptune Medical Inc. | Dynamically rigidizing composite medical structures |
US11554248B1 (en) | 2018-07-19 | 2023-01-17 | Neptune Medical Inc. | Rigidizing devices |
US20210128889A1 (en) * | 2018-07-20 | 2021-05-06 | Olympus Corporation | Guide wire holder |
US11351023B2 (en) | 2018-08-21 | 2022-06-07 | Claret Medical, Inc. | Systems and methods for protecting the cerebral vasculature |
US10966709B2 (en) | 2018-09-07 | 2021-04-06 | Neochord, Inc. | Device for suture attachment for minimally invasive heart valve repair |
US10624762B2 (en) | 2018-09-07 | 2020-04-21 | Orthorebirth Usa | Bone graft delivery device for minimally invasive surgery |
US11357500B2 (en) * | 2018-09-12 | 2022-06-14 | Lsi Solutions, Inc. | Surgical suturing device for repair of tricuspid regurgitation and methods thereof |
WO2020072895A1 (en) * | 2018-10-04 | 2020-04-09 | The University Of Chicago | Lima crossover integrated catheter system |
US10912644B2 (en) | 2018-10-05 | 2021-02-09 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US11672657B2 (en) | 2018-10-05 | 2023-06-13 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US10987221B2 (en) | 2018-10-10 | 2021-04-27 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10993809B2 (en) | 2018-10-10 | 2021-05-04 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11278409B2 (en) | 2018-10-10 | 2022-03-22 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11129717B2 (en) | 2018-10-10 | 2021-09-28 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11147672B2 (en) | 2018-10-10 | 2021-10-19 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US10945844B2 (en) | 2018-10-10 | 2021-03-16 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11083582B2 (en) | 2018-10-10 | 2021-08-10 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11344415B2 (en) | 2018-10-10 | 2022-05-31 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11202710B2 (en) | 2018-10-10 | 2021-12-21 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11234823B2 (en) | 2018-10-10 | 2022-02-01 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11000375B2 (en) | 2018-10-10 | 2021-05-11 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11766330B2 (en) | 2018-10-10 | 2023-09-26 | Edwards Lifesciences Corporation | Valve repair devices for repairing a native valve of a patient |
US11116484B2 (en) * | 2018-10-31 | 2021-09-14 | Hongming Zhu | Lens assembly for 3D electronic nasopharyngoscope |
US11510723B2 (en) | 2018-11-08 | 2022-11-29 | Dfine, Inc. | Tumor ablation device and related systems and methods |
US11937864B2 (en) | 2018-11-08 | 2024-03-26 | Dfine, Inc. | Ablation systems with parameter-based modulation and related devices and methods |
US20200268238A1 (en) * | 2018-12-21 | 2020-08-27 | Ambu A/S | Articulated tip part for an endoscope |
US11963874B2 (en) | 2019-01-28 | 2024-04-23 | Vesalius Cardiovascular Inc. | Apparatus for use in repairing mitral valves and method of use thereof |
US20220142778A1 (en) * | 2019-01-28 | 2022-05-12 | Vesalius Cardiovascular Inc. | Apparatus for use in repairing mitral valves and method of use thereof |
US11135421B2 (en) * | 2019-02-07 | 2021-10-05 | Synecor Llc | Conduit for transseptal passage of devices to the aorta |
US11839544B2 (en) | 2019-02-14 | 2023-12-12 | Edwards Lifesciences Corporation | Heart valve sealing devices and delivery devices therefor |
US11471282B2 (en) | 2019-03-19 | 2022-10-18 | Shifamed Holdings, Llc | Prosthetic cardiac valve devices, systems, and methods |
US11376126B2 (en) | 2019-04-16 | 2022-07-05 | Neochord, Inc. | Transverse helical cardiac anchor for minimally invasive heart valve repair |
US11918468B2 (en) | 2019-04-16 | 2024-03-05 | Neochord, Inc. | Transverse helical cardiac anchor for minimally invasive heart valve repair |
US11793392B2 (en) | 2019-04-17 | 2023-10-24 | Neptune Medical Inc. | External working channels |
US11660189B2 (en) | 2019-07-15 | 2023-05-30 | Evalve, Inc. | Wide clip with nondeformable wings |
US11850151B2 (en) | 2019-07-15 | 2023-12-26 | Evalve, Inc. | Proximal element actuator fixation and release mechanisms |
US11707228B2 (en) | 2019-09-26 | 2023-07-25 | Evalve, Inc. | Systems and methods for intra-procedural cardiac pressure monitoring |
US11464636B2 (en) | 2019-10-11 | 2022-10-11 | Evalve, Inc. | Repair clip for variable tissue thickness |
US11759190B2 (en) | 2019-10-18 | 2023-09-19 | Boston Scientific Medical Device Limited | Lock for medical devices, and related systems and methods |
US11819411B2 (en) | 2019-10-29 | 2023-11-21 | Edwards Lifesciences Innovation (Israel) Ltd. | Annuloplasty and tissue anchor technologies |
US11969226B2 (en) | 2019-11-04 | 2024-04-30 | Momentis Surgical Ltd | Modular device comprising mechanical arms |
US11622859B2 (en) | 2019-11-08 | 2023-04-11 | Evalve, Inc. | Medical device delivery system with locking system |
US11801087B2 (en) | 2019-11-13 | 2023-10-31 | Boston Scientific Medical Device Limited | Apparatus and methods for puncturing tissue |
US11801140B2 (en) | 2019-11-14 | 2023-10-31 | Evalve, Inc. | Catheter assembly with coaptation aid and methods for valve repair |
US11701229B2 (en) | 2019-11-14 | 2023-07-18 | Evalve, Inc. | Kit with coaptation aid and fixation system and methods for valve repair |
US20210145510A1 (en) * | 2019-11-18 | 2021-05-20 | Nido Surgical Inc. | Instrument port for epicardial ablation with inflatable balloon |
US11724070B2 (en) | 2019-12-19 | 2023-08-15 | Boston Scientific Medical Device Limited | Methods for determining a position of a first medical device with respect to a second medical device, and related systems and medical devices |
US11547286B2 (en) * | 2020-01-22 | 2023-01-10 | Brio13Inv. LLC | Stylet assembly |
US11931098B2 (en) | 2020-02-19 | 2024-03-19 | Boston Scientific Medical Device Limited | System and method for carrying out a medical procedure |
US11819243B2 (en) | 2020-03-19 | 2023-11-21 | Boston Scientific Medical Device Limited | Medical sheath and related systems and methods |
US11744443B2 (en) | 2020-03-30 | 2023-09-05 | Neptune Medical Inc. | Layered walls for rigidizing devices |
US11826075B2 (en) | 2020-04-07 | 2023-11-28 | Boston Scientific Medical Device Limited | Elongated medical assembly |
US11534303B2 (en) | 2020-04-09 | 2022-12-27 | Evalve, Inc. | Devices and systems for accessing and repairing a heart valve |
US11938285B2 (en) | 2020-06-17 | 2024-03-26 | Boston Scientific Medical Device Limited | Stop-movement device for elongated medical assembly |
US11793446B2 (en) | 2020-06-17 | 2023-10-24 | Boston Scientific Medical Device Limited | Electroanatomical mapping system with visualization of energy-delivery and elongated needle assemblies |
US11937796B2 (en) | 2020-06-18 | 2024-03-26 | Boston Scientific Medical Device Limited | Tissue-spreader assembly |
US11969346B2 (en) | 2021-01-29 | 2024-04-30 | Edwards Lifesciences Corporation | Heart valve coaptation device |
US11969347B2 (en) | 2021-05-11 | 2024-04-30 | Evalve, Inc. | Methods, systems, and devices for deploying an implant |
US11969348B2 (en) | 2021-08-26 | 2024-04-30 | Edwards Lifesciences Corporation | Cardiac valve replacement |
US20230248956A1 (en) * | 2022-02-10 | 2023-08-10 | St. Jude Medical, Cardiology Division, Inc. | Integrated Hemostasis Bypass Valve |
US11937778B2 (en) | 2022-04-27 | 2024-03-26 | Neptune Medical Inc. | Apparatuses and methods for determining if an endoscope is contaminated |
Also Published As
Publication number | Publication date |
---|---|
US8123703B2 (en) | 2012-02-28 |
WO2004103434A2 (en) | 2004-12-02 |
US7682319B2 (en) | 2010-03-23 |
EP1624792B1 (en) | 2019-06-19 |
EP1624792A4 (en) | 2010-06-02 |
JP2007511248A (en) | 2007-05-10 |
EP1624792A2 (en) | 2006-02-15 |
EP3539454A1 (en) | 2019-09-18 |
WO2004103434A3 (en) | 2005-08-04 |
US20100130924A1 (en) | 2010-05-27 |
US20090156995A1 (en) | 2009-06-18 |
EP3539454B1 (en) | 2023-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7682319B2 (en) | Steerable access sheath and methods of use | |
US11590321B2 (en) | Catheter guiding system and methods | |
US8409273B2 (en) | Multi-catheter steerable guiding system and methods of use | |
US9326815B2 (en) | Asymmetric dual directional steerable catheter sheath | |
JP5188811B2 (en) | Manual device for remote control of gripping tools | |
EP2626012B1 (en) | Deflecting guide catheter for mitral valve treatment | |
US7090637B2 (en) | Articulating mechanism for remote manipulation of a surgical or diagnostic tool | |
JP3752564B2 (en) | Deflection control system | |
US20200222667A1 (en) | Steerable sheath with variable curve span | |
JP2008523910A (en) | Operable guide catheter and method of using the same | |
JP2008512212A (en) | Expandable transseptal sheath | |
KR20210153660A (en) | Dynamic stiffening of complex medical structures | |
EP3881755A1 (en) | Steerable sheath with variable curve span | |
WO2023211863A1 (en) | Steerable system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: EVALVE, NC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MARTIN, BRIAN B.;RAATIKKA, AMY R.;THORNTON, TROY L.;AND OTHERS;REEL/FRAME:014030/0441;SIGNING DATES FROM 20030908 TO 20030915 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: ABBOTT VASCULAR INC., CALIFORNIA Free format text: SECURITY AGREEMENT;ASSIGNOR:EVALVE, INC.;REEL/FRAME:023245/0637 Effective date: 20090909 Owner name: ABBOTT VASCULAR INC.,CALIFORNIA Free format text: SECURITY AGREEMENT;ASSIGNOR:EVALVE, INC.;REEL/FRAME:023245/0637 Effective date: 20090909 |