US20040073081A1 - Probe for dielectric and optical diagnosis - Google Patents

Probe for dielectric and optical diagnosis Download PDF

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Publication number
US20040073081A1
US20040073081A1 US10/469,337 US46933703A US2004073081A1 US 20040073081 A1 US20040073081 A1 US 20040073081A1 US 46933703 A US46933703 A US 46933703A US 2004073081 A1 US2004073081 A1 US 2004073081A1
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Prior art keywords
tissue
measuring probe
fact
endoscopic
probe
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Abandoned
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US10/469,337
Inventor
Werner Schramm
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Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
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Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
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Assigned to FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. reassignment FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SCHRAMM, WERNER
Publication of US20040073081A1 publication Critical patent/US20040073081A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles

Definitions

  • the invention relates to an endoscopic measuring probe for medical diagnostics for simultaneously detecting dielectric and optical parameters at the same measuring site.
  • the field of application relates to the diagnosis of tumors measuring the surface of the tissue as well as measuring by penetration into the surface.
  • U.S. Pat. No. 5,800,350 describes a measuring probe which by contacting the tissue makes it possible to detect a plurality of different physical parameters of the tissue, including electrical and optical ones.
  • the electrodes for electrical measurements positioned at the front surface of the measuring probe are structured and arranged such that upon placing the probe on the tissue, different resistance paths between a center electrode and separate electrode segments at the periphery are measured to be compared to ensure a reproducible position of the probe on the tissue. Decay rates of current pulses sent through the tissue may also be evaluated.
  • light conducting fibers are provided in the probe which carry light from light sources to the tissue and return it to corresponding receivers.
  • German patent specification DE 198 54 292 proposes a multiple parameter measuring system in which the measuring probe used is provided with a separate coaxial cable and, laterally offset therefrom, various light conducting fibers for optical spectroscopy.
  • FIG. 1 depicts the principle of a measuring system in which the endoscopic measuring probe is connected to an operating apparatus by a coupling module;
  • FIG. 2 shows the distribution of light conducting fibers of different function over the cross-section of a coaxial arrangement
  • FIG. 3 depicts examples of applications for contact measurements of a tissue
  • FIG. 1 depicts the principle structure of a measuring system for the spatially precise dielectric and optico-spectroscopic diagnosis of biological fiber.
  • the cylindrical endoscopic measuring probe 2 including shaft 3 and coupling module 4 , it shows the operating apparatus 5 connected by a coaxial cable 421 and a light conducting fiber 422 .
  • the measuring probe is structured as a combination electrical wave conductor and light conducting fiber probe.
  • the space between the metallic exterior sheath 21 and the coaxial internal conductor 22 is filled by a dielectric substance of light conducting fibers 23 .
  • the wave resistance z of the system should be selected such that it corresponds to the wave resistance of the coaxial cable connected by the coupling module 4 .
  • the wave resistance z is calculated on the basis of the diameter D of the exterior sheath 21 , the internal diameter d of the internal conductor 22 and the dielectric constant ⁇ T by the equation
  • the measuring probe 2 terminates in a shaft 3 to which is connected a coupling module 4 which consists of a connector 41 with a female connector portion 42 .
  • the coupling module 4 in turn is connected by a coaxial cable 421 and light conducting cable 422 to an operating apparatus 5 required for the operation of the measuring probe.
  • the operating apparatus contains signal sources and signal receivers for dielectric and optical spectroscopy.
  • FIG. 2 depicts a cross-section of the measuring probe in accordance with the invention, which is provided with differently functioning light conducting fibers.
  • the light conducting fibers are uniformly distributed over the cross-section to ensure the characteristics of a symmetrical wave conductor.
  • 231 represents excitation fibers for carrying excitation light of, for instance, 337 nm to the tissue; 232 are fibers for measuring the fluorescence of the tissue; 233 are fibers which detect the scattering of excitation light in the tissue; and 234 depicts fibers for surface Raman spectroscopy.
  • FIG. 3 depicts two cases of application of differently structured front surfaces of the measuring probe 2 in accordance with the invention.
  • FIG. 4 a shows an endoscopic measuring probe 2 having a front surface 201 structured as a point for use in invasive measurements within the tissue 1 .
  • FIG. 4 b depicts the case of application in which the measuring probe 2 has a planar front surface 202 to be placed on the tissue 1 for performing measurements.

Abstract

An endoscopic measuring probe for medical diagnosis providing an array by means of which both dielectric and optical parameters can be detected at a given site of the tissue during measurement. The measuring probe is formed by a coaxial array of metal outer sheaths and a metal inner conductor, wherein the dielectric consists of light conducting fibers.

Description

  • The invention relates to an endoscopic measuring probe for medical diagnostics for simultaneously detecting dielectric and optical parameters at the same measuring site. The field of application relates to the diagnosis of tumors measuring the surface of the tissue as well as measuring by penetration into the surface. [0001]
  • Several measuring systems have become known for executing multiple measurements of tissue to distinguish tumorous tissue from healthy tissue. [0002]
  • For instance, U.S. Pat. No. 5,800,350 describes a measuring probe which by contacting the tissue makes it possible to detect a plurality of different physical parameters of the tissue, including electrical and optical ones. [0003]
  • The electrodes for electrical measurements positioned at the front surface of the measuring probe are structured and arranged such that upon placing the probe on the tissue, different resistance paths between a center electrode and separate electrode segments at the periphery are measured to be compared to ensure a reproducible position of the probe on the tissue. Decay rates of current pulses sent through the tissue may also be evaluated. [0004]
  • For detecting the optical properties of the tissue, for which purpose wavelengths of 540, 650, 660, 940 and 1,300 nm are considered to be of particularly high diagnostic value, light conducting fibers are provided in the probe which carry light from light sources to the tissue and return it to corresponding receivers. [0005]
  • German patent specification DE 198 54 292 proposes a multiple parameter measuring system in which the measuring probe used is provided with a separate coaxial cable and, laterally offset therefrom, various light conducting fibers for optical spectroscopy. [0006]
  • The disadvantage of the two mentioned measuring systems is that the measuring site for the impedance measurement does not precisely coincide with the site for the optico-spectroscopic measurements. [0007]
  • It is thus an object of the invention to provide a system which during performance of a measurement makes possible simultaneous detection of dielectric as well as optical parameters at a predetermined site. [0008]
  • The object is accomplished by an arrangement in accordance with claim [0009] 1. Advantageous embodiments are the subject of the sub-claims.
  • By the combination in accordance with the invention of electric wave conductors and optical light conducting fibers in the measuring probe, several diagnostic parameters may be accurately detected at the same tissue area. This is of decisive importance for accurately distinguishing between a tumor and healthy tissue. The small required space advantageously facilitates the fabrication of very thin endoscopic measuring probes. [0010]
  • The invention will be explained in greater detail on the basis of embodiments.[0011]
  • In the drawings: [0012]
  • FIG. 1 depicts the principle of a measuring system in which the endoscopic measuring probe is connected to an operating apparatus by a coupling module; [0013]
  • FIG. 2 shows the distribution of light conducting fibers of different function over the cross-section of a coaxial arrangement; [0014]
  • FIG. 3 depicts examples of applications for contact measurements of a tissue [0015]
  • [0016] 3 a invasively; and
  • [0017] 3 b non-invasively, engagingly.
  • FIG. 1 depicts the principle structure of a measuring system for the spatially precise dielectric and optico-spectroscopic diagnosis of biological fiber. In addition to the cylindrical [0018] endoscopic measuring probe 2 including shaft 3 and coupling module 4, it shows the operating apparatus 5 connected by a coaxial cable 421 and a light conducting fiber 422.
  • The measuring probe is structured as a combination electrical wave conductor and light conducting fiber probe. The space between the [0019] metallic exterior sheath 21 and the coaxial internal conductor 22 is filled by a dielectric substance of light conducting fibers 23. The wave resistance z of the system should be selected such that it corresponds to the wave resistance of the coaxial cable connected by the coupling module 4.
  • As is well known (Meinke, Grundiach: Handbuch der Hochfrequenztechnik, 3rd Edition, Springer, 1968, page 255), the wave resistance z is calculated on the basis of the diameter D of the [0020] exterior sheath 21, the internal diameter d of the internal conductor 22 and the dielectric constant εT by the equation
  • z=60/εT −1/2 In D/d.
  • At its distal end, the [0021] measuring probe 2 terminates in a shaft 3 to which is connected a coupling module 4 which consists of a connector 41 with a female connector portion 42. The coupling module 4 in turn is connected by a coaxial cable 421 and light conducting cable 422 to an operating apparatus 5 required for the operation of the measuring probe. The operating apparatus contains signal sources and signal receivers for dielectric and optical spectroscopy.
  • FIG. 2 depicts a cross-section of the measuring probe in accordance with the invention, which is provided with differently functioning light conducting fibers. The light conducting fibers are uniformly distributed over the cross-section to ensure the characteristics of a symmetrical wave conductor. [0022] 231 represents excitation fibers for carrying excitation light of, for instance, 337 nm to the tissue; 232 are fibers for measuring the fluorescence of the tissue; 233 are fibers which detect the scattering of excitation light in the tissue; and 234 depicts fibers for surface Raman spectroscopy.
  • FIG. 3 depicts two cases of application of differently structured front surfaces of the [0023] measuring probe 2 in accordance with the invention. FIG. 4a shows an endoscopic measuring probe 2 having a front surface 201 structured as a point for use in invasive measurements within the tissue 1. FIG. 4b depicts the case of application in which the measuring probe 2 has a planar front surface 202 to be placed on the tissue 1 for performing measurements.
    • List of Reference Characters
  • [0024] 1 tissue
  • [0025] 2 measuring probe
  • [0026] 201 front surface structured as a point
  • [0027] 202 planar front surface
  • [0028] 21 metallic exterior sheath
  • [0029] 22 metallic internal conductor
  • [0030] 23 light conducting fibers
  • [0031] 231 excitation fibers
  • [0032] 232 fibers for measuring fluorescence
  • [0033] 233 fibers for measuring remission
  • [0034] 234 fibers for surface Raman spectroscopy
  • [0035] 3 shaft of the endoscopic measuring probe
  • [0036] 4 coupling module
  • [0037] 41 plug portion
  • [0038] 42 female connector portion
  • [0039] 421 coaxial cable
  • [0040] 422 light conducting fiber
  • [0041] 5 apparatus for operating the measuring probe

Claims (4)

1. An endoscopic measuring probe for multi parameter diagnostics of biological tissue, characterized by the fact that a cylindrical measuring head (2) structured as a coaxial wave conductor for contacting the tissue (1) to be examined, is provided with a metallic external sheath (21) and a coaxial internal conductor (22), the space between the two being filled by a dielectric substance of light conducting fibers (23) which as groups or individually transmit light of predetermined wavelength from signal sources to the tissue or away from them to optical receivers, the measuring head at its distal end terminating in a shaft (3) with a coupling module (4) which, consisting of a connector (41) with a female connector portion (42), constitutes a separable interface to the operating apparatus (5).
2. The endoscopic measuring probe of claim 1, characterized by the fact that the light conducting fibers as a dielectric substance are uniformly distributed over the cross-section.
3. The endoscopic measuring probe of claim 1 and 2, characterized by the fact that its proximal end is structured as a point (201) for penetration into the tissue (1).
4. The endoscopic measuring probe of claim 1 and 2, characterized by the fact that its proximal end is provided with a planar front surface (202).
US10/469,337 2001-02-27 2001-02-27 Probe for dielectric and optical diagnosis Abandoned US20040073081A1 (en)

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PCT/EP2001/002194 WO2002067774A1 (en) 2001-02-27 2001-02-27 Probe for dielectric and optical diagnosis

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EP (1) EP1372465B1 (en)
JP (1) JP2004526488A (en)
AT (1) ATE365500T1 (en)
DE (1) DE50112675D1 (en)
WO (1) WO2002067774A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005122878A1 (en) * 2004-06-15 2005-12-29 Umc Utrecht Holding B.V. Method and device for the detection of cancer
US20080171949A1 (en) * 2007-01-17 2008-07-17 The University Hospital Of North Staffordshire Nhs Trust Intraoperative electromagnetic apparatus and related technology
US20120041284A1 (en) * 2010-08-13 2012-02-16 Conopco, Inc., D/B/A Unilever Camera device for evaluating condition of skin or hair
US20120041283A1 (en) * 2010-08-13 2012-02-16 Conopco, Inc., D/B/A Unilever Device for evaluating condition of skin or hair
JP2013532508A (en) * 2010-07-21 2013-08-19 キマ メディカル テクノロジーズ リミテッド Embedded dielectric measurement system
US9326685B2 (en) 2012-09-14 2016-05-03 Conopco, Inc. Device for evaluating condition of skin or hair
US10548485B2 (en) 2015-01-12 2020-02-04 Zoll Medical Israel Ltd. Systems, apparatuses and methods for radio frequency-based attachment sensing
US10588599B2 (en) 2008-05-27 2020-03-17 Zoll Medical Israel Ltd. Methods and systems for determining fluid content of tissue
US10680324B2 (en) 2013-10-29 2020-06-09 Zoll Medical Israel Ltd. Antenna systems and devices and methods of manufacture thereof
US11013420B2 (en) 2014-02-05 2021-05-25 Zoll Medical Israel Ltd. Systems, apparatuses and methods for determining blood pressure
US11020002B2 (en) 2017-08-10 2021-06-01 Zoll Medical Israel Ltd. Systems, devices and methods for physiological monitoring of patients
US11259715B2 (en) 2014-09-08 2022-03-01 Zoll Medical Israel Ltd. Monitoring and diagnostics systems and methods

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013204586A1 (en) * 2013-03-15 2014-09-18 Siemens Aktiengesellschaft Sensor and method for determining a dielectric property of a medium

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US4274419A (en) * 1979-10-19 1981-06-23 Quinton Instrument Co. Skin preparation device and method used in the application of medical electrodes
US5928159A (en) * 1995-03-03 1999-07-27 Neothermia Corporation Apparatus and method for characterization and treatment of tumors
US6317615B1 (en) * 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6337994B1 (en) * 1998-04-30 2002-01-08 Johns Hopkins University Surgical needle probe for electrical impedance measurements

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ZA948393B (en) 1993-11-01 1995-06-26 Polartechnics Ltd Method and apparatus for tissue type recognition
DE19854292C2 (en) 1998-11-19 2000-11-30 Werner Schramm Method and arrangement for multiparametric diagnosis of biological tissue

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4274419A (en) * 1979-10-19 1981-06-23 Quinton Instrument Co. Skin preparation device and method used in the application of medical electrodes
US5928159A (en) * 1995-03-03 1999-07-27 Neothermia Corporation Apparatus and method for characterization and treatment of tumors
US6337994B1 (en) * 1998-04-30 2002-01-08 Johns Hopkins University Surgical needle probe for electrical impedance measurements
US6317615B1 (en) * 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005122878A1 (en) * 2004-06-15 2005-12-29 Umc Utrecht Holding B.V. Method and device for the detection of cancer
US20080171949A1 (en) * 2007-01-17 2008-07-17 The University Hospital Of North Staffordshire Nhs Trust Intraoperative electromagnetic apparatus and related technology
GB2445758A (en) * 2007-01-17 2008-07-23 Univ Hospital Of North Staffor Intraoperative electromagnetic apparatus and related technology
US10588599B2 (en) 2008-05-27 2020-03-17 Zoll Medical Israel Ltd. Methods and systems for determining fluid content of tissue
US11471127B2 (en) 2009-12-01 2022-10-18 Zoll Medical Israel Ltd. Methods and systems for determining fluid content of tissue
US10660609B2 (en) 2009-12-01 2020-05-26 Zoll Medical Israel Ltd. Methods and systems for determining fluid content of tissue
JP2013532508A (en) * 2010-07-21 2013-08-19 キマ メディカル テクノロジーズ リミテッド Embedded dielectric measurement system
US10136833B2 (en) 2010-07-21 2018-11-27 Zoll Medical Israel, Ltd. Implantable radio-frequency sensor
US9788752B2 (en) 2010-07-21 2017-10-17 Zoll Medical Israel Ltd. Implantable dielectrometer
US20120041283A1 (en) * 2010-08-13 2012-02-16 Conopco, Inc., D/B/A Unilever Device for evaluating condition of skin or hair
US20120041284A1 (en) * 2010-08-13 2012-02-16 Conopco, Inc., D/B/A Unilever Camera device for evaluating condition of skin or hair
US9326685B2 (en) 2012-09-14 2016-05-03 Conopco, Inc. Device for evaluating condition of skin or hair
US11108153B2 (en) 2013-10-29 2021-08-31 Zoll Medical Israel Ltd. Antenna systems and devices and methods of manufacture thereof
US11539125B2 (en) 2013-10-29 2022-12-27 Zoll Medical Israel Ltd. Antenna systems and devices, and methods of manufacture thereof
US10680324B2 (en) 2013-10-29 2020-06-09 Zoll Medical Israel Ltd. Antenna systems and devices and methods of manufacture thereof
US11013420B2 (en) 2014-02-05 2021-05-25 Zoll Medical Israel Ltd. Systems, apparatuses and methods for determining blood pressure
US11883136B2 (en) 2014-02-05 2024-01-30 Zoll Medical Israel Ltd. Systems, apparatuses and methods for determining blood pressure
US11259715B2 (en) 2014-09-08 2022-03-01 Zoll Medical Israel Ltd. Monitoring and diagnostics systems and methods
US11241158B2 (en) 2015-01-12 2022-02-08 Zoll Medical Israel Ltd. Systems, apparatuses and methods for radio frequency-based attachment sensing
US10548485B2 (en) 2015-01-12 2020-02-04 Zoll Medical Israel Ltd. Systems, apparatuses and methods for radio frequency-based attachment sensing
US11020002B2 (en) 2017-08-10 2021-06-01 Zoll Medical Israel Ltd. Systems, devices and methods for physiological monitoring of patients
US11872012B2 (en) 2017-08-10 2024-01-16 Zoll Medical Israel Ltd. Systems, devices and methods for physiological monitoring of patients

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Publication number Publication date
WO2002067774A1 (en) 2002-09-06
ATE365500T1 (en) 2007-07-15
EP1372465B1 (en) 2007-06-27
EP1372465A1 (en) 2004-01-02
JP2004526488A (en) 2004-09-02
DE50112675D1 (en) 2007-08-09

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