US20040143207A1 - Apparatus usable in haemofiltration treatment - Google Patents
Apparatus usable in haemofiltration treatment Download PDFInfo
- Publication number
- US20040143207A1 US20040143207A1 US10/699,098 US69909803A US2004143207A1 US 20040143207 A1 US20040143207 A1 US 20040143207A1 US 69909803 A US69909803 A US 69909803A US 2004143207 A1 US2004143207 A1 US 2004143207A1
- Authority
- US
- United States
- Prior art keywords
- blood
- patient
- pump
- oxygenating device
- oxygenating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3626—Gas bubble detectors
Definitions
- the present invention relates to an apparatus usable in CRRT (Continuous Renal Replacement Therapy) treatment.
- CRRT Continuous Renal Replacement Therapy
- haemodialysis haemofiltration
- ultrafiltration all of which provide for removing waste products from the patient. That is, the patient's blood is fed through filters or membranes to eliminate the waste substances in it, and is then fed back to the patient.
- CAVH Continuous ArterioVenous Haemofiltration
- CVVH Continuous VenoVenous Haemofiltration
- CRRT CRRT
- a CRRT machine comprises a central unit connected at the input and output to the patient, e.g. by means of one or more catheters inserted inside corresponding blood vessels, to continuously withdraw the blood for treatment and feed back the treated blood.
- the central unit of a CRRT machine normally comprises a blood pump, blood heating and processing means, such as, heparin adding means, means for feeding refill liquid into the blood, and a haemofilter.
- the blood withdrawn continuously from the patient is thus pumped by the blood pump along the machine circuit, heparin and appropriately heated refill liquid is added, and the blood is then filtered before being fed back to the patient.
- the advantages of the apparatus according to the present invention substantially lie in greatly improving “decapneisation”, i.e. in greatly reducing the CO 2 values of the blood.
- reducing FiO 2 from 100 to 70% has been found to increase O 2 saturation of the patient from 92 to 100%. This is extremely important, in that the poor capacity of the lung to exchange O 2 constitutes a serious complication in many patients.
- Another advantage lies in the principle of the present invention being applicable to existing machines, which can be altered to achieve more complete, more effective performance.
- the characteristics of an apparatus in accordance with the invention remain unchanged with very little maintenance.
- FIG. 1 shows, schematically and not to scale, one possible embodiment of a CRRT apparatus in accordance with the present invention.
- Number 1 in FIG. 1 indicates as a whole a CRRT apparatus in accordance with the present invention.
- Apparatus 1 is connected at the input to a patient P by a first conduit 9 , which may be defined, for example, by a Horizon Medical Product DLC600 KC 11.5 Fr or DLC 800 KC femoral catheter.
- a first conduit 9 which may be defined, for example, by a Horizon Medical Product DLC600 KC 11.5 Fr or DLC 800 KC femoral catheter.
- Other means may, of course be used to connect the apparatus to the patient, and data relative to other component parts described herein is also provided purely by way of non-limiting examples.
- Catheter 9 is connected to a conduit 90 , which is fitted with and acted on downstream by a blood pump 3 ; a gauge 20 is also provided to measure the intake arterial pressure of the patient.
- the successive portions of the path along which the blood flows are defined by conduit portions 91 , 92 , 93 , 94 and 95 .
- Pump 3 pumps the blood downstream (in the direction shown by the arrows) to a connecting member 4 , after first adding heparin by means of a conduit 50 connected to conduit 91 and to a heparin tank (syringe) 5 .
- a conduit 60 is connected to the input of connecting member 4 to supply, by means of a pump 61 , a refill liquid or infusion contained in a tank 6 and heated by heating means 62 .
- a gauge 40 is provided at connecting member 4 to measure the pressure at that point along the path.
- conduit portion 92 Downstream from connecting member 4 , conduit portion 92 is connected to an oxygenating device 7 or “decapneisator”, which may be a Jostra Polystan mycro or Jostra Safe mycro neonatal type, and which is connected by a conduit 77 to an oxygen tank 78 , and is fitted inside with an oxygenating membrane 71 .
- Oxygenating device 7 provides for supplying oxygen to eliminate CO 2 from the blood; for which purpose, CO 2 is eliminated through an outlet 70 of device 7 and sent to measuring means not shown.
- conduit portion 93 Downstream from “decapneisator” 7 , conduit portion 93 is connected to a blood filter or haemofilter 8 having an output connected to a conduit 80 for discharging ultrafiltrate into a collecting tank 81 .
- Conduit 80 is fitted with control means 82 , which may be defined, for example, by a detector for detecting blood loss in the ultrafiltrate, and which acts directly on conduit 80 .
- Blood filter 8 may be a currently marketed type, such as a MEDICA company MEDISULFONE D200 haemofilter.
- Apparatus 1 according to the present invention advantageously does not employ an ultrafiltrate pump, in that, using oxygenating device 7 , ultrafiltration takes place naturally, in a more physiologically correct manner.
- conduit portion 94 Downstream from filter 8 , conduit portion 94 is connected to a member 49 defined by a venous vessel and having a gauge 48 for measuring the pressure of the return blood to the patient.
- conduit portion 95 Downstream from member 49 , conduit portion 95 —which is fitted with an air detector 47 to prevent emboli (e.g. a UABD ultrasonic air bubble detector)—is connected to a return catheter 9 ′ for feeding the blood back to patient P.
- emboli e.g. a UABD ultrasonic air bubble detector
- an apparatus in accordance with the present invention comprises a CRRT machine, and an oxygenating device or “decapneisator”.
- the CRRT machine may be an Equasmart Medica equipped with appropriate connecting tubes, catheters, connections, etc.
- the apparatus is advantageous in all cases in which the oxygen concentration of the blood requires supplementing, and especially in eliminating CO 2 in patients in which correct substitute respiration therapy is difficult to apply.
- the apparatus is connected to the patient undergoing CVVH treatment, and a patient weight loss is set as required. For example, a total weight loss of 2400 g and an hourly loss of 100 g may be programmed. These two parameters determine a treatment time of 24 hours. Administration of an anticoagulant equal to 1.5 times the blood coagulation time may be set; in which case, a pump flow rate (QB) of 280-300 ml/min and an oxygen flow rate (QO 2 ) of 500 ml/min will be programmed.
- QB pump flow rate
- QO 2 oxygen flow rate
- the patient is connected to a CRRT machine, using an oxygenating device located and acting upstream from the blood filter and downstream from the blood pump.
- This location of the oxygenating device is particularly important. In fact, it means the oxygenating membranes of the oxygenating device operate without the intake (negative) pressure along the portion upstream from the blood pump, and also without the blood concentration characteristic of the venous portion, which could eventually impair their efficiency.
- a weight loss i.e. the quantity of liquid to be drained
- An anticoagulant infusion in line with standard CRRT protocols will therefore be provided, with a blood flow rate (QB) of over 300 ml/min, and an oxygen flow rate (QO 2 ) higher than QB. It is important to continuously monitor both coagulation time, which must be kept constantly at one and a half times normal, and oxygen saturation, haematocrit, blood volume values, etc.
- a CRITE-LINE or similar apparatus may be used.
Abstract
The invention relates to an apparatus for CRRT therapy of the type performable using a haemofiltration machine, having connecting means from and to respective blood vessels of a patient, blood processing means including a pump, means for adding drugs or other therapeutic substances, means for feeding refill liquid into the blood, and blood filtration means, cascade-connected to one another by relative conduits; the apparatus also having an oxygenating device.
Description
- The present invention relates to an apparatus usable in CRRT (Continuous Renal Replacement Therapy) treatment.
- As is known, for various reasons, it may prove necessary to supplement or replace the renal function of patients to remove waste liquids and soluble substances, such as substances administered to the patient and/or waste substances contained in the blood as a result of pathology, surgery, etc.
- Various procedures are employed for this purpose, including haemodialysis, haemofiltration, and ultrafiltration, all of which provide for removing waste products from the patient. That is, the patient's blood is fed through filters or membranes to eliminate the waste substances in it, and is then fed back to the patient.
- For patients in grave conditions, procedures include Continuous ArterioVenous Haemofiltration (CAVH), Continuous VenoVenous Haemofiltration (CVVH), or, in general, CRRT as defined above. In this type of procedure, the patient is connected permanently to the haemofiltration machine for a prolonged period of time.
- Examples of known CRRT machines are described in U.S. Pat. No. 5,211,849 and U.S. Pat. No. 6,349,170. That is, a CRRT machine comprises a central unit connected at the input and output to the patient, e.g. by means of one or more catheters inserted inside corresponding blood vessels, to continuously withdraw the blood for treatment and feed back the treated blood. The central unit of a CRRT machine normally comprises a blood pump, blood heating and processing means, such as, heparin adding means, means for feeding refill liquid into the blood, and a haemofilter. The blood withdrawn continuously from the patient is thus pumped by the blood pump along the machine circuit, heparin and appropriately heated refill liquid is added, and the blood is then filtered before being fed back to the patient.
- A major drawback of currently used CRRT systems is their slow speed in relation to patient requirements.
- Another drawback of known CRRT systems is the compulsory use of a pump for the ultrafiltrate, which is less tolerable by chronic, haemodynamically unstable patients whose refill capacity is always unknown.
- It is a main object of the present invention to eliminate the aforementioned drawbacks.
- According to the present invention, there is provided a CRRT apparatus as claimed in
claim 1 and the dependent claims. - The advantages of the apparatus according to the present invention substantially lie in greatly improving “decapneisation”, i.e. in greatly reducing the CO2 values of the blood. By way of example, reducing FiO2 from 100 to 70% has been found to increase O2 saturation of the patient from 92 to 100%. This is extremely important, in that the poor capacity of the lung to exchange O2 constitutes a serious complication in many patients. Another advantage lies in the principle of the present invention being applicable to existing machines, which can be altered to achieve more complete, more effective performance. Moreover, the characteristics of an apparatus in accordance with the invention remain unchanged with very little maintenance.
- A non-limiting embodiment of the present invention will be described by way of example with reference to the accompanying drawing, in which:
- FIG. 1 shows, schematically and not to scale, one possible embodiment of a CRRT apparatus in accordance with the present invention.
-
Number 1 in FIG. 1 indicates as a whole a CRRT apparatus in accordance with the present invention. -
Apparatus 1 is connected at the input to a patient P by afirst conduit 9, which may be defined, for example, by a Horizon Medical Product DLC600 KC 11.5 Fr or DLC 800 KC femoral catheter. Other means may, of course be used to connect the apparatus to the patient, and data relative to other component parts described herein is also provided purely by way of non-limiting examples. -
Catheter 9 is connected to aconduit 90, which is fitted with and acted on downstream by ablood pump 3; agauge 20 is also provided to measure the intake arterial pressure of the patient. The successive portions of the path along which the blood flows are defined byconduit portions -
Pump 3 pumps the blood downstream (in the direction shown by the arrows) to a connectingmember 4, after first adding heparin by means of aconduit 50 connected toconduit 91 and to a heparin tank (syringe) 5. Aconduit 60 is connected to the input of connectingmember 4 to supply, by means of apump 61, a refill liquid or infusion contained in atank 6 and heated byheating means 62. - A
gauge 40 is provided at connectingmember 4 to measure the pressure at that point along the path. - Downstream from connecting
member 4,conduit portion 92 is connected to anoxygenating device 7 or “decapneisator”, which may be a Jostra Polystan mycro or Jostra Safe mycro neonatal type, and which is connected by aconduit 77 to anoxygen tank 78, and is fitted inside with anoxygenating membrane 71.Oxygenating device 7 provides for supplying oxygen to eliminate CO2 from the blood; for which purpose, CO2 is eliminated through anoutlet 70 ofdevice 7 and sent to measuring means not shown. - Downstream from “decapneisator”7,
conduit portion 93 is connected to a blood filter orhaemofilter 8 having an output connected to aconduit 80 for discharging ultrafiltrate into acollecting tank 81.Conduit 80 is fitted with control means 82, which may be defined, for example, by a detector for detecting blood loss in the ultrafiltrate, and which acts directly onconduit 80. -
Blood filter 8 may be a currently marketed type, such as a MEDICA company MEDISULFONE D200 haemofilter. -
Apparatus 1 according to the present invention advantageously does not employ an ultrafiltrate pump, in that, usingoxygenating device 7, ultrafiltration takes place naturally, in a more physiologically correct manner. - Downstream from
filter 8,conduit portion 94 is connected to amember 49 defined by a venous vessel and having agauge 48 for measuring the pressure of the return blood to the patient. - Downstream from
member 49,conduit portion 95—which is fitted with anair detector 47 to prevent emboli (e.g. a UABD ultrasonic air bubble detector)—is connected to areturn catheter 9′ for feeding the blood back to patient P. - In other words, an apparatus in accordance with the present invention comprises a CRRT machine, and an oxygenating device or “decapneisator”. By way of example, the CRRT machine may be an Equasmart Medica equipped with appropriate connecting tubes, catheters, connections, etc.
- Testing has revealed numerous advantages.
- In particular, the apparatus is advantageous in all cases in which the oxygen concentration of the blood requires supplementing, and especially in eliminating CO2 in patients in which correct substitute respiration therapy is difficult to apply.
- In actual use, the apparatus is connected to the patient undergoing CVVH treatment, and a patient weight loss is set as required. For example, a total weight loss of 2400 g and an hourly loss of 100 g may be programmed. These two parameters determine a treatment time of 24 hours. Administration of an anticoagulant equal to 1.5 times the blood coagulation time may be set; in which case, a pump flow rate (QB) of 280-300 ml/min and an oxygen flow rate (QO2) of 500 ml/min will be programmed.
- At therapy method level, with the present invention, the patient is connected to a CRRT machine, using an oxygenating device located and acting upstream from the blood filter and downstream from the blood pump. This location of the oxygenating device is particularly important. In fact, it means the oxygenating membranes of the oxygenating device operate without the intake (negative) pressure along the portion upstream from the blood pump, and also without the blood concentration characteristic of the venous portion, which could eventually impair their efficiency.
- Again at therapy level, a weight loss (i.e. the quantity of liquid to be drained) may be set as required in each specific case, i.e. as prescribed by the physician. An anticoagulant infusion in line with standard CRRT protocols will therefore be provided, with a blood flow rate (QB) of over 300 ml/min, and an oxygen flow rate (QO2) higher than QB. It is important to continuously monitor both coagulation time, which must be kept constantly at one and a half times normal, and oxygen saturation, haematocrit, blood volume values, etc. For this purpose, a CRITE-LINE or similar apparatus may be used.
- Clearly, changes may be made to the form, dimensions, component part locations, and type of materials employed in the embodiment described and illustrated herein without, however, departing from the scope of the present invention.
Claims (5)
1) An apparatus for CRRT therapy of the type performable using a haemofiltration machine, comprising connecting means (9, 9′) from and to respective blood vessels of a patient, blood processing means comprising a pump (3), means for adding drugs or other therapeutic substances (5), means for feeding refill liquid into the blood (6), and blood filtration means (8), cascade-connected to one another by relative conduits; characterized by comprising an oxygenating device (7).
2) An apparatus as claimed in claim 1 , characterized in that said oxygenating device (7) is located downstream from blood processing means comprising a blood pump (3).
3) An apparatus as claimed in claim 1 , characterized in that said oxygenating device (7) is located upstream from the blood filtration means (8).
4) An apparatus as claimed in claim 1 , characterized in that said oxygenating device (7) is located upstream from the blood filtration means (8) and downstream from blood processing means comprising a blood pump (3).
5) An apparatus as claimed in claim 1 , characterized in that said oxygenating device (7) comprises an oxygenating membrane (71), is connected to an oxygen tank (78), and has an outlet (70) through which carbon dioxide is eliminated.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/043,696 US7942842B2 (en) | 2002-10-31 | 2008-03-06 | Apparatus and method for the treatment of blood |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000208A ITFI20020208A1 (en) | 2002-10-31 | 2002-10-31 | EQUIPMENT USED IN HEMOFILTRATION TREATMENTS. |
ITFI2002A000208 | 2002-10-31 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/043,696 Continuation US7942842B2 (en) | 2002-10-31 | 2008-03-06 | Apparatus and method for the treatment of blood |
Publications (1)
Publication Number | Publication Date |
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US20040143207A1 true US20040143207A1 (en) | 2004-07-22 |
Family
ID=32088997
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/699,098 Abandoned US20040143207A1 (en) | 2002-10-31 | 2003-10-30 | Apparatus usable in haemofiltration treatment |
US12/043,696 Active 2024-10-20 US7942842B2 (en) | 2002-10-31 | 2008-03-06 | Apparatus and method for the treatment of blood |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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US12/043,696 Active 2024-10-20 US7942842B2 (en) | 2002-10-31 | 2008-03-06 | Apparatus and method for the treatment of blood |
Country Status (6)
Country | Link |
---|---|
US (2) | US20040143207A1 (en) |
EP (1) | EP1415673B2 (en) |
AT (1) | ATE457757T2 (en) |
DE (1) | DE60331281D1 (en) |
ES (1) | ES2341324T5 (en) |
IT (1) | ITFI20020208A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080243045A1 (en) * | 2003-10-03 | 2008-10-02 | Medical Service S.R.L | Apparatus and method for the treatment of blood |
EP2606921A1 (en) | 2011-12-21 | 2013-06-26 | Infomed SA | Device for purifying blood by extracorporeal circulation |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITFI20030256A1 (en) * | 2003-10-09 | 2005-04-10 | Angela Caramuta | DEVICE FOR THE ELIMINATION OF CARBON DIOXIDE |
US8105491B2 (en) * | 2004-04-27 | 2012-01-31 | Vital Therapies, Inc. | Metabolic detoxification and method |
EP2238995A1 (en) * | 2009-04-09 | 2010-10-13 | Gazzano, Michele | System for the treatment of blood |
ITBO20120197A1 (en) * | 2012-04-12 | 2013-10-13 | Medical Service S R L | EQUIPMENT USED IN MECHANICAL OR ASSISTED VENTILATION PROCEDURES |
CN104971391A (en) * | 2015-06-19 | 2015-10-14 | 南方医科大学珠江医院 | Novel combined type liver and kidney support system CRRT mode tube |
ITUB20159161A1 (en) * | 2015-12-18 | 2017-06-18 | Eurosets Srl | EQUIPMENT FOR BLOOD DECAPNIZATION |
ITUB20159389A1 (en) | 2015-12-18 | 2017-06-18 | Eurosets Srl | EQUIPMENT FOR BLOOD DECAPNIZATION |
IT201700038389A1 (en) * | 2017-04-07 | 2018-10-07 | In10Sivecare S R L | Equipment for extracorporeal blood treatment |
DE102021109242A1 (en) | 2021-04-13 | 2022-10-13 | B.Braun Avitum Ag | Extracorporeal circuit for decapneization of organic fluids |
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US5858238A (en) * | 1996-03-08 | 1999-01-12 | Baxter Research Medical, Inc. | Salvage of autologous blood via selective membrane/sorption technologies |
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US5211849B1 (en) * | 1991-10-11 | 1997-05-27 | Childrens Hosp Medical Center | Hemofiltration system and method |
US5368555A (en) * | 1992-12-29 | 1994-11-29 | Hepatix, Inc. | Organ support system |
US6193681B1 (en) * | 1998-09-14 | 2001-02-27 | American Immuno Tech, Llc. | Septicemia prevention and treatment system |
DE19858950A1 (en) * | 1998-12-09 | 2000-06-29 | Robby Knueppel | Device for extra-corporal exchange of gas and substances in blood, comprises two exchange chambers with semi-permeable membranes |
JP2001178817A (en) * | 1999-12-24 | 2001-07-03 | Terumo Corp | Device for artificial kidney, quality evaluating device using the same and fluid circuit |
CN100346869C (en) * | 2001-02-07 | 2007-11-07 | 尼弗茹斯公司 | Method and apparatus for hemodiafiltration delivery module |
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2002
- 2002-10-31 IT IT000208A patent/ITFI20020208A1/en unknown
-
2003
- 2003-10-30 EP EP03025039.3A patent/EP1415673B2/en not_active Expired - Lifetime
- 2003-10-30 US US10/699,098 patent/US20040143207A1/en not_active Abandoned
- 2003-10-30 ES ES03025039.3T patent/ES2341324T5/en not_active Expired - Lifetime
- 2003-10-30 AT AT03025039T patent/ATE457757T2/en active
- 2003-10-30 DE DE60331281T patent/DE60331281D1/en not_active Expired - Lifetime
-
2008
- 2008-03-06 US US12/043,696 patent/US7942842B2/en active Active
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US4828543A (en) * | 1986-04-03 | 1989-05-09 | Weiss Paul I | Extracorporeal circulation apparatus |
US5858238A (en) * | 1996-03-08 | 1999-01-12 | Baxter Research Medical, Inc. | Salvage of autologous blood via selective membrane/sorption technologies |
US6626857B1 (en) * | 1998-11-19 | 2003-09-30 | Tomio Ohta | Extracorporeal circulation device and method for isolation temperature control method |
US6561997B1 (en) * | 1999-04-23 | 2003-05-13 | The Regents Of The University Of Michigan | Extracorporeal fluid circuit and related methods |
US20020077581A1 (en) * | 2000-12-19 | 2002-06-20 | Alan Davidner | Simplified cerebral retroperfusion apparatus and method |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080243045A1 (en) * | 2003-10-03 | 2008-10-02 | Medical Service S.R.L | Apparatus and method for the treatment of blood |
US8070952B2 (en) | 2003-10-03 | 2011-12-06 | Medical Service S.R.L. | Apparatus and method for the treatment of blood |
EP2606921A1 (en) | 2011-12-21 | 2013-06-26 | Infomed SA | Device for purifying blood by extracorporeal circulation |
Also Published As
Publication number | Publication date |
---|---|
EP1415673B1 (en) | 2010-02-17 |
ES2341324T5 (en) | 2018-10-24 |
EP1415673A1 (en) | 2004-05-06 |
US20080154171A1 (en) | 2008-06-26 |
ATE457757T2 (en) | 2010-03-15 |
US7942842B2 (en) | 2011-05-17 |
ES2341324T3 (en) | 2010-06-18 |
EP1415673B2 (en) | 2018-06-20 |
ITFI20020208A1 (en) | 2004-05-01 |
DE60331281D1 (en) | 2010-04-01 |
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Owner name: FREEVIEW VENTURES LLC, TEXAS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DELLA TORRE, FLORENZIANO;REEL/FRAME:015176/0502 Effective date: 20040219 |
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